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Wade Mark M Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia, Via Adamello 16, 20139 Milan, - - 2013
The MDM2 and MDMX (also known as HDMX and MDM4) proteins are deregulated in many human cancers and exert their oncogenic activity predominantly by inhibiting the p53 tumour suppressor. However, the MDM proteins modulate and respond to many other signalling networks in which they are embedded. Recent mechanistic studies and ...
Eng Wei Kay - - 2013
Human biotin requirements are unknown and the identification of reliable markers of biotin status is necessary to fill this knowledge gap. Here, we used an outpatient feeding protocol to create states of biotin deficiency, sufficiency and supplementation in sixteen healthy men and women. A total of twenty possible markers of ...
Matusow Harlan - - 2013
The most critical unresolved issue associated with psychoanalysis is whether its core precepts belong in today's substance use armamentarium. Psychoanalytic theories have resisted the criterion of falsifiability, putting them at odds with the current paradigm for treating addiction. However, Freud's earliest pronouncement on the subject, "making the patient a collaborator ...
Ottaviani Daniela - - 2013
ABSTRACT Background: Retinoblastoma is a hereditary cancer of childhood caused by mutations in the RB1 tumor suppressor gene. An early diagnosis is critical for survival and eye preservation, thus identification of RB1 mutations is important for unequivocal diagnosis of hereditary retinoblastoma and risk assessment in relatives. Methods: We studied 144 ...
Cerutti Erika - - 2013
DPA-713 is the lead compound of a recently reported pyrazolo[1,5-a]pyrimidineacetamide series, targeting the translocator protein (TSPO 18 kDa), and as such, this structure, as well as closely related derivatives, have been already successfully used as positron emission tomography radioligands. On the basis of the pharmacological core of this ligands series, a ...
Zuo Lihua - - 2013
In this study, the enantioseparation of zopiclone, repaglinide, chlorphenamine maleate, brompheniramine maleate, dioxopromethazine hydrochloride, promethazine hydrochloride, liarozole, carvedilol, homatropine hydrobromide, homatropine methylbromide, venlafaxine, and sibutramine hydrochloride has been investigated using β-CD in combination with a chiral ionic liquid (IL), 1-ethyl-3-methylimidazolium-L-lactate. The influence of the type of IL and its concentration, ...
Byun Ju-Young - - 2013
A method has been developed for the direct conversion of DNA arrays into three dimensional protein arrays on a hydrogel matrix. An agarose gel embedded with bacterial protein synthesis machinery was used as the DNA-programmable expression gel matrix for the in situ translation of genes on a DNA array. Upon ...
Bolko Katarina - - 2013
Abstract Context: Despite its promising therapeutic activities, clinical use of resveratrol (RSV) is compromised with unfavorable biopharmaceutical properties, namely low water solubility. Objective: This work deals with improving RSV solubility and release rate through its incorporation in innovative mixed lipid phase self-microemulsifying drug delivery systems (SMEDDS). Methods: (Pseudo)ternary diagrams were ...
Kamar Rita - - 2013
Preterm infants admitted to the Neonatal Intensive Care Unit (NICU) often receive either umbilical- or peripheral arterial lines, for frequent blood sampling and monitoring arterial blood pressure. However, arterial lines can lead to severe complications [1] such as tissue ischemia and as a result necrosis of extremities. The consequences of ...
Jia Kun - - 2013
A commercial TEM grid was used as a mask for the creation of extremely well-organized gold micro-/nano-structures on a glass substrate via a high temperature annealing process at 500 °C. The structured substrate was (bio)functionalized and used for the high throughput LSPR immunosensing of different concentrations of a model protein ...
Wang Qi - - 2013
The toxicity of cinnabar, a naturally occurring mercury sulfide (HgS), has long been referred to soluble mercury chloride (HgCl(2) ). To investigate whether the speciation of mercury plays a role in its disposition and toxicity, we hereby investigated and compared cinnabar with soluble HgCl(2) and pure insoluble HgS in mice ...
Dréno B - - 2013
In the adult female, acne is a chronic condition with a substantial negative psychological, social and emotional impact. Based on time of onset, two subtypes of adult female acne are recognized: 'persistent acne' is a continuation of the disease from adolescence, while 'late-onset acne' first presents in adulthood. The morphological ...
Grugni Graziano - - 2013
OBJECTIVE: The assessment of GH deficiency in adult patients with Prader-Willi syndrome (PWS) has been previously assessed through the evaluation of quantitative parameters, such as the peak value of GH response to exogenous stimuli. A comprehensive description of the pattern of secretory response obtainable by deconvolution analysis is still lacking. ...
Zhang Shulian - - 2013
Wiskott-Aldrich syndrome (WAS) is a rare X-linked recessive disease characterized by eczema, thrombocytopenia and immune deficiency. WAS gene mutations impair WAS protein function which cause WAS. The WAS-related disorders of X-linked thrombocytopenia (XLT) and X-linked congenital neutropenia (XLN) may have similar but less severe symptoms those are also caused by ...
Gómez-Arriaga Pi - - 2013
OBJECTIVE: to evaluate the performance of the mean pulsatility index of uterine arteries (mPI-UtA) and the automated measurement of sFlt-1/PlGF ratio at suspicion or diagnosis of pre-eclampsia (PE). METHODS: singleton pregnancies with PE (n=60), diagnosed following current recommendations, or with suspected PE (n=32), defined either by i) blood pressure (BP) ...
Malta Tathiane Maistro - - 2013
HTLV-1 is the etiologic agent of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). CD8+ T cells may contribute to the protection or development of HAM/TSP. In this study we used SAGE methodology to screen for differentially expressed genes in CD8+ T cells isolated from HTLV-1 asymptomatic carriers (HAC) and from HAM/TSP ...
Sakly C - - 2013
Reproductive outputs in fat-tailed Barbarine sheep in central Tunisia are often low because of feed shortage and the low nutritive value of diets. Supplementation with conventional concentrates is economically unsuitable in central Tunisia, so more cost-effective and sustainable alternative feeding strategies need to be developed. We tested effects of short-term ...
Vallooran Jijo J - - 2013
We present a new strategy to control the anisotropic diffusion of hydrophilic drugs in lyotropic liquid crystals, via dispersion of magnetic nanoparticles in the mesophase, followed by re-orientation of the mesophase domains via an external magnetic field. We select a lipid reverse hexagonal phase doped with magnetic iron-oxide nanoparticles and ...
Moul Adrienne - - 2013
Osteogenesis imperfecta is a rare connective tissue disorder characterized by bone fragility and low bone density. Most cases are caused by an autosomal dominant mutation in either COL1A1 or COL1A2 gene encoding type I collagen. However, autosomal recessive forms have been identified. We present a patient with severe respiratory distress ...
Anne Sorensen - - 2013
OBJECTIVES: The purpose of this study was to investigate changes in human placental oxygenation during maternal hyperoxia by using the non-invasive blood oxygen level dependent (BOLD) magnetic resonance imaging (MRI) technique. METHODS: Eight healthy pregnant women in gestational week 28 to 36 were included in the study. By using a ...
Kuuranne Tiia T Doping Control Laboratory, United Medix Laboratories, Höyläämötie 14, 00380, Helsinki, - - 2013
Human chorionic gonadotropin (hCG) is dimeric glycoprotein produced by placenta in pregnancy and also in low levels by pituitary gland. The main clinical use for exogenous hCG-administration is typically linked to infertility. The desired effect of hCG misuse in sport is due to the enhancement of testicular production of testosterone. ...
Pankewitz F - - 2013
BACKGROUND: The prevalence of onychomycosis has increased steadily in the last decade. An accurate diagnosis at the outset is important for successful and cost-effective treatment of patients. However, current diagnostic tests for onychomycosis are neither rapid nor sensitive nor specific. OBJECTIVES: Therefore, we developed a microsatellite-based PCR-ELISA (MS-ELISA) assay for ...
von Heideken Johan - - 2013
AIM: To investigate how sociodemographic factors relate to the risk femur shaft fractures in children, and how the relationship differs by gender and age. METHODS: Population based case-control study. Swedish children (n=1,874), 0-14 years of age, with a femur shaft fracture diagnostic code occurring between 1997 and 2005 were selected ...
Sariyildiz M A - - 2013
The aim of this study was to explore the impact of ankylosing spondylitis (AS) and the disease-related variables, psychological status and the quality of life on the female patients' sexual function measured according to the Female Sexual Function Index (FSFI). Thirty-seven sexually active female AS patients and 33 healthy controls ...
Bai Yu - - 2013
AIM: Recently Gastroesophageal Reflux Disease Questionnaire (GerdQ) has been developed for diagnosis of GERD. However, no study investigated its value in real-world practice. This study aimed to investigate whether GerdQ can be used for diagnosis of GERD in China. METHODS: A national multicenter survey was undertaken; all patients who underwent ...
Sumathipala Athula - - 2013
The Sri Lankan Twin Registry (SLTR), established in 1997, is a unique resource for twin and genetic research in a low- and middle-income country (LMIC). It comprises of a volunteer cohort of 14,120 twins (7,060 pairs) and 119 sets of triplets, and a population-based cohort of 19,040 (9,520 pairs) twins ...
Nader Ingo W - - 2013
Knowledge about suicide postvention (KSPV) is an important distal outcome in the evaluation of suicide prevention programs that focus on the bereaved. However, most scales are specifically tailored to the evaluation study in question and psychometric properties are often unsatisfactory. Therefore, we developed the KSPV scale. Scale properties were investigated ...
Wang Jiang - - 2013
Abstract Objective: We investigated the myocardial protective effect of sevoflurane in patients receiving off-pump coronary artery bypass grafting (OPCABG) and the role of brain natriuretic peptide (BNP). Design: Forty-eight patients receiving elective OPCABG were randomly assigned to a control group, and 0.75 MAC, 1.0 MAC and 1.5 MAC sevoflurane groups. ...
Behari Professor Madhuri - - 2013
Abstract Platelets play an important role in a variety of disorders viz; cardiovascular, psychosomatic, psychiatric, thrombosis, HIV/AIDS in addition to various neurodegenerative diseases (NDD). Recent evidence indicates that platelet react to diverse stressors thereby offering an interesting vantage point for understanding their potential role in contemporary medical research. This review ...
Reichardt Niels C - - 2013
Glyconanotechnology can be seen as the synergy between nanotechnology and glycan related biological and medical problems. This review focuses on the crosstalk of glycoscience and nanotechnology, which will lead to a deeper understanding of glycobiology and to new glyco-materials with improved design and synergistic properties derived from glycoscience concepts for ...
Harte C B - - 2013
Cigarette smoking deleteriously affects erectile function, and conversely, quitting smoking improves erectile hemodynamics. Underlying mechanisms by which smoking (or reduction of smoking frequency) may affect erectile physiology are not well understood. This study examined the mediating role of heart rate variability (HRV; a marker of sympathovagal balance) among a sample ...
Hu Yuwei - - 2013
In very recent years, polyaniline or its derivatives have been adopted to efficiently immobilize probe DNA via π-π interaction between conjugated interface and DNA bases. In this work, self-doped polyaniline (SPAN)-DNA hybrid was adopted as the platform to construct a DNA biosensor with label-free, reagentless and electrochemical self-signal amplifying features. ...
Hilliard P - - 2013
BACKGROUND: Full-dose prophylaxis is very effective at minimizing joint damage but is costly. Tailored prophylaxis has been proposed as a way of reducing costs while still protecting joints. OBJECTIVE: To report detailed findings in index joints of 56 subjects with severe hemophilia A entered into the Canadian Hemophilia Prophylaxis Study, ...
Xiao Lizu - - 2013
OBJECTIVE.: We aim to determine the effects of botulinum toxin type A (BTX-A) on the thresholds of pain and the expression of transient receptor potential vanilloid type 1 (TRPV1) in the dorsal root ganglion (DRG) in rats with neuropathic pain induced by selective ventral root transection (VRT). METHODS.: Neuropathic pain ...
Kanda Miyuki - - 2013
The Hox1 gene in the urochordate ascidian Ciona intestinalis (Ci-Hox1) is expressed in the nerve cord and epidermis. We identified a nerve cord enhancer in the second intron of Ci-Hox1, and demonstrated that retinoic acid (RA) plays a major role in activating this enhancer. The enhancer contained a putative retinoic ...
Probst C - - 2013
On 26 November 2000, the first autochthonous case of bovine spongiform encephalopathy (BSE) was detected in Germany. Since then, a total of 413 BSE cases have been confirmed, resulting in the culling and destruction of 17 313 heads of cattle. In view of the possible risks for human and animal health, ...
Mun J-H - - 2013
BACKGROUND: Subungual haemorrhages are characterised by well-circumscribed dots or blotches with a red to red-black pigmentation, but some cases can be difficult to distinguish from subungual melanoma by the naked eye alone. Dermoscopy has proven to be a useful, noninvasive tool in the diagnosis of pigmented lesions in the nail; ...
Sheraz A - - 2013
A 43 year old caucasion gentleman had been receiving Botulinum toxin type A injections (BOTOX(®) , Allergan) for his axillary hyperhidrosis since 2004 with good effect. In June 2009 he gave an 18 month history of developing small prutitic wheals on his chest, arms and to a lesser extent his ...
Zhong Yuan - - 2013
Cell shape is known to have profound effects on a number of cell behaviors. In this paper we have studied its role in cell migration through modeling the effect of cell shape on the cell traction force distribution, the traction force dependent stability of cell adhesion and the matrix rigidity ...
Kochuvareed Mampilly Tomy - - 2013
Neuroimaging and molecular cytogenetics were used to ascertain the cause of disability in a case. The case was diagnosed to be a variant of Miller-Dieker syndrome (MDS). Retrospective analysis showed a prenatal scan reporting dolichocephaly. We evaluated dolichocephaly, the name associated with a nonsynostotic cause to be a physiological variant ...
Deng Hui H Department of Dermatology, University of Colorado, Denver, Aurora, Colorado 80045, - - 2013
Carboxyl-terminal binding protein 1 (CtBP1) has been shown to suppress the transcription of several tumor suppressors in vitro. Paradoxically, a previous report showed that CtBP1 mRNA was downregulated in melanoma. Using immunostaining, we found that a large percentage of human melanomas were positive for CtBP1 protein. Furthermore, we demonstrated that ...
Geneletti S S Department of Statistics, London School of Economics and Political Science, Houghton Street, London, WC2A 2AE, - - 2013
Case-control studies are particularly prone to selection bias, which can affect odds ratio estimation. Approaches to discovering and adjusting for selection bias have been proposed in the literature using graphical and heuristic tools as well as more complex statistical methods. The approach we propose is based on a survey-weighting method ...
Gomes H F - - 2013
The systemic oxidative status in hypertensives disorders of pregnancy (HDP) and its association with endothelial dysfunction is controversial. In the present study, we evaluated systemic plasma levels of oxidative stress markers (TBARS (thiobarbituric acid-reactive substances) and carbonyl) and total antioxidant status (FRAP (ferric reducing ability of plasma (ferric reducing/antioxidant power) ...
Chen Kai - - 2013
Enhancing catalytic selectivity of supported metal nanoparticles with capping ligands is demonstrated using an Au/SiO(2) catalyst in liquid phase aerobic oxidation of benzyl alcohol. Chemisorption of an appropriate amount of polyvinylpyrrolidone on the Au/SiO(2) catalyst greatly enhances the benzaldehyde selectivity from 43% to ∼100% and its yield from 4.9% to ...
Chartier Karen G - - 2013
The moderating effects of ethnicity and gender on factors associated with physical health consequences in adults manifesting alcohol dependence were examined using data from the 2001-2002 US National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Black and white respondents with a lifetime diagnosis of DSM-IV alcohol dependence were selected ...
Boonstra Mirjam - - 2013
When starved, Bacillus subtilis cells can enter the developmental program of endospore formation by activation of the master transcriptional regulator Spo0A. Correct chromosome copy number is crucial for the production of mature and fully resistant spores. The production and maintenance of one chromosome for the mother cell and one copy ...
Rhondali Wadih - - 2013
Objective: In a simultaneous care model, patients have concurrent access to both cancer-directed therapies and palliative care. As oncologists play a critical role in determining the need/timing of referral to palliative care programs, their understanding of the service and ability to communicate this with patients is of paramount importance. Our ...
De Vrieze Jo J Laboratory of Microbial Ecology and Technology (LabMET), Ghent University, Coupure Links 653, B-9000, Gent, - - 2013
Anaerobic digestion is an environmental key technology in the future bio-based economy. To achieve functional stability, a minimal microbial community diversity is required. This microbial community should also have a certain 'elasticity', i.e. the ability to rapidly adapt to suboptimal conditions or stress. In this study it was evaluated whether ...
Mavrelos Dimitrios - - 2013
OBJECTIVE: To validate the efficacy and safety of our clinical protocol for expectant management of selected women diagnosed with tubal ectopic pregnancy. METHODS: This was a prospective observational study carried out in the Early Pregnancy Unit (EPU) of a London inner city university teaching hospital from the 1(st) of January ...
Shahare Brigesh - - 2013
Abstract As the use of silver nanoparticles is increasing fast in industry, food, medicines, etc., exposure to silver nanoparticles is increasing in quantity day by day. So, it is imperative to know the adverse effects of silver nanoparticles in man. In this study, we selected mice as an animal model ...
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