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Chen Ling - - 2013
Plants are one of the most economical platforms for large-scale production of recombinant proteins for biopharmaceutical and industrial uses. A large number of human recombinant proteins of therapeutic value have been successfully produced in plant systems. One of the main technical challenges of producing recombinant proteins in plants is to ...
Ribeiro José A - - 2013
In this work, the ion transfer mechanism of anticancer drug daunorubicin (DNR) at a liquid/liquid interface has been studied for the first time. This study was carried out using electrochemical techniques namely cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The lipophilicity of DNR was investigated at the water/1,6-dichlorohexane (DCH) ...
Dasgupta Rajdeep - - 2013
The onset of melting in the Earth's upper mantle influences the thermal evolution of the planet, fluxes of key volatiles to the exosphere, and geochemical and geophysical properties of the mantle. Although carbonatitic melt could be stable 250 km or less beneath mid-oceanic ridges, owing to the small fraction (∼0.03 wt%) ...
Canale A - - 2013
In this paper we describe acoustically the wing-fanning behaviour showed by the male of the braconid Psyttalia concolor towards females and other conspecific males. Psyttalia concolor is a synovigenic koinobiont larval-pupal endoparasitoid of many Tephritidae, used in olive crops to control the olive fruit fly, Bactrocera oleae. In this braconid ...
Xue F - - 2013
MicroRNA (miRNA) has an important role as a master regulator of gene expression in immune system and is upregulated during T cell differentiation, however its function is not clear yet. In this study, the contribution of miR-31 in T cell activation was investigated. miR-31 was upregulated during the activation of ...
Herce H D - - 2013
The spatial relationship, or degree of colocalization, between two or more types of molecules in live cells is commonly detected using fluorescence microscopy. This spatial distribution can be used to estimate the interaction between fluorescently labelled molecules. These interactions are usually quantified by analysing the correlation and/or the overlap between ...
Matthews Jacqueline M - - 2013
LIM-domain proteins are a large family of proteins that are emerging as key molecules in a wide variety of human cancers. In particular, all members of the human LIM-domain-only (LMO) proteins, LMO1-4, which are required for many developmental processes, are implicated in the onset or the progression of several cancers, ...
Iannacone Michelle R - - 2013
Genus-β human papillomavirus (HPV) DNA has been detected in basal cell carcinoma (BCC) tumors, but most epidemiologic studies have not observed associations between genus-β HPV seropositivity and BCC. A clinic-based case-control study was conducted to investigate cutaneous HPV infection in BCC. BCC cases (n=224) were recruited from a dermatology clinic, ...
Brunasso A M G - - 2013
BACKGROUND: The International Psoriasis Council in 2007 considered palmoplantar pustulosis (PPP) as a separate condition from psoriasis, despite the presence of certain phenotypes common in both diseases. OBJECTIVE: To describe and compare demographic and clinical characteristics among PPP and palmoplantar plaque psoriasis. METHODS: Retrospective case-series study from 2005 to 2010. ...
Koukuntla Ramesh - - 2013
BACKGROUND: Nearly one third of all human genetic diseases are due to nonsense mutations that can result in truncated proteins. Nonsense suppressor tRNAs (NSTs) were proposed as valuable tools for gene therapy of genetic diseases caused by premature termination codons (PTCs). Although various strategies were adapted over the years to ...
Primack Brian A - - 2013
Associations between the emerging trend of waterpipe tobacco smoking and mental health among college students have not been sufficiently explored. This study analyzed data collected from 152 academic institutions that participated in the National College Health Assessment during the 2008-2009 academic year to examine associations between mental health and waterpipe ...
Mujico Jorge R - - 2013
Consumption of a high-fat diet (HFD), which is associated with chronic 'low-grade' systemic inflammation, alters the gut microbiota (GM). The aim of the present study was to investigate the ability of an oleic acid-derived compound (S1) and a combination of n-3 fatty acids (EPA and DHA, S2) to modulate both ...
Feng Ruopeng - - 2013
Transcriptional factor Sox2 is essential for regulation of self-renewal and homeostasis of neural stem cells (NSCs) during brain development. However, the downstream targets of Sox2 and the underlying molecular mechanism are largely unknown. In this study, we found that Sox2 directly up-regulates the expression of survivin, which inhibits the mitochondria-dependent ...
Richard-Devantoy S - - 2013
OBJECTIVE: To compare cognitive inhibition performance between people with early-onset (EOD) or late-onset depression (LOD) and controls, and between women and men with LOD. METHODS: On the basis of a case-control design, global executive performance (Frontal Assessment Battery); verbal (Hayling), attention (Stroop), and motor (Go/No-Go) components of cognitive inhibition; mental ...
Blache Y - - 2013
Arm swing helps to increase vertical jump height (VJH), in part by a greater hip joint muscle work. The force-velocity relationship has been put forward to explain the increase in hip joint work. Nevertheless, the efficacy ratio, muscle shortening length, and active state might be parameters that affect the effective ...
Kobayashi Yuka - - 2013
A single crystal of anilinium tetrathiafulvalene-2-carboxylate exhibits a characteristic electrical conduction; it is a semiconductor with activation-type transport above 200 K; σ(rt) = 0.16 S cm(-1) with an activation energy of 0.11 eV. On the other hand, below 200 K, it does not obey the Arrhenius relation but is conductive ...
Teng Xu - - 2013
Background: Eosinophilic gastroenteritis (EG) is an increasingly recognized inflammatory disease characterized by gastrointestinal (GI) symptoms and eosinophilic infiltration of the GI tract. Serosal form is one subtype of EG. The aetiology and pathogenesis of EG are unknown and the diagnosis and treatment properly are difficult for physician. Methods: A retrospective ...
Xuan Yan - - 2013
Based on increasing evidence from animal and human studies, vitamin D deficiency is now regarded as a potential risk factor for type 2 diabetes (T2D). Vitamin D is involved in the pathogenesis of pancreatic β-cell dysfunction, insulin resistance and systemic inflammation, conditions that contribute to the development of T2D. Vitamin ...
Shiomi1 Daisuke - - 2013
RodZ interacts with MreB and both factors are required to maintain the rod shape of Escherichia coli. The assembly of MreB into filaments regulates the subcellular arrangement of a group of enzymes that synthesizes the peptidoglycan (PG) layer. However, it is still unknown how polymerization of MreB determines the rod ...
Sun Jie - - 2013
Electromagnetic phased arrays at radio frequencies are well known and have enabled applications ranging from communications to radar, broadcasting and astronomy. The ability to generate arbitrary radiation patterns with large-scale phased arrays has long been pursued. Although it is extremely expensive and cumbersome to deploy large-scale radiofrequency phased arrays, optical ...
Li Jianhao - - 2013
A direct asymmetric Mannich reaction of N-unprotected 3-bromooxindoles with N-Ts-imines catalyzed by bifunctional thiourea derived from 2-substituted cinchona alkaloid was developed. Products with vicinal chiral tertiary and brominated quaternary stereogenic centers were achieved in excellent diastereo- and enantioselectivity (up to 99 : 1 dr, 99% ee).
Wade Mark - - 2013
The MDM2 and MDMX (also known as HDMX and MDM4) proteins are deregulated in many human cancers and exert their oncogenic activity predominantly by inhibiting the p53 tumour suppressor. However, the MDM proteins modulate and respond to many other signalling networks in which they are embedded. Recent mechanistic studies and ...
Eng Wei Kay - - 2013
Human biotin requirements are unknown and the identification of reliable markers of biotin status is necessary to fill this knowledge gap. Here, we used an outpatient feeding protocol to create states of biotin deficiency, sufficiency and supplementation in sixteen healthy men and women. A total of twenty possible markers of ...
Matusow Harlan - - 2013
The most critical unresolved issue associated with psychoanalysis is whether its core precepts belong in today's substance use armamentarium. Psychoanalytic theories have resisted the criterion of falsifiability, putting them at odds with the current paradigm for treating addiction. However, Freud's earliest pronouncement on the subject, "making the patient a collaborator ...
Pencovich N - - 2013
Cancer progression from microscopic dormant tumors into disseminated disease involves tumor angiogenesis, and is commonly referred to as the 'angiogenic switch'. CD11b(+)Gr1(+) immature myeloid cells (IMCs) were reported to promote angiogenesis and tumor progression. Here, we studied a model of tumor dormancy, in which Lewis Lung Carcinoma tumor cells were ...
Kaytanli B - - 2013
We propose a novel and algorithmically simple Hough transform method that exploits the geometric properties of ellipses to enable the robust determination of the ellipse position and properties. We make use of the unique features of the evolute created by Hough voting along the gradient vectors of a two-dimensional image ...
Tsiamas Panagiotis - - 2013
This study determines the optimal clinical scenarios for gold nanoparticle dose enhancement as a function of irradiation conditions and potential biological targets using megavoltage x-ray beams. Four hundred and eighty clinical beams were studied for different potential cellular or sub-cellular targets. Beam quality was determined based on a 6 MV ...
Cluver Catherine - - 2013
Congenital rubella infection has been associated with a number of abnormalities including cardiac, central nervous system and placental complications. We present a case with multiple fetal abnormalities detected on prenatal ultrasound, and confirmed postnatally, including single umbilical artery, severe tricuspid regurgitation, micrognathia and agenesis of the inferior cerebellar vermis. Postnatal ...
Sun Hui - - 2013
Shengmaisan (SMS) is a traditional Chinese medicine prescription widely used for the treatment of cardiovascular diseases in Asia. Its lignans are major components responsible for therapeutic action. A rapid and specific UPLC-Q-TOF/MS has been developed and validated for simultaneous quantification of the five main bioactive components, i.e. schisandrin, schisandrol B, ...
Cilurzo Francesco - - 2013
Abstract Objective: To evaluate the feasibility of a transdermal patch containing propranolol (PR). Method: Skin penetration enhancers (SPEs) able to improve the skin permeability of PR were selected and a quality by design approach was applied to the development of the patch by a 2(4) full factorial design. The permeation ...
Meyer Markus R - - 2013
Naphyrone (1-naphthalen-2-yl-2-pyrrolidin-1-yl-pentan-1-one; naphthylpyrovalerone, β-naphyrone) is a cathinone designer drug and was marketed as replacement for the synthetic cathinone derivative mephedrone. Meanwhile, naphyrone is also classified as a controlled drug in several countries. Therefore, the aim of this study was to identify the metabolites of naphyrone in rat urine using gas ...
Koelsch Bertram L - - 2013
We combined the high MR signal enhancement achieved using dissolution dynamic nuclear polarization (DNP) with a pulsed gradient double spin echo diffusion MR sequence to rapidly and accurately measure the diffusion coefficients of various hyperpolarized (13)C molecules in solution. Furthermore, with a diffusion-weighted imaging sequence we generate diffusion coefficient maps ...
Parcq J - - 2013
BACKGROUND: Thrombolysis using tissue plasminogen activator (tPA) is the only treatment approved for acute ischemic stroke. Although tPA is an efficient clot lysis enzyme, it also produces damage of the neurovascular unit including hemorrhagic transformations and neurotoxicity. OBJECTIVES: Based on the mechanism of action of tPA on neurotoxicity, we aimed ...
Liu Hailong - - 2013
Many haloarchaea are known as polyhydroxyalkanoates (PHAs) producers, but a global and integrated view of the PHA biosynthesis is still lacking in this group of archaea. In this study, a combined proteomic and transcriptomic approach was employed in Haloarcula hispanica, a model haloarchaeon that accumulates poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) under nutrient-limiting conditions ...
Carmichael R J - - 2013
Equine herpes myeloencephalopathy, resulting from equine herpes virus type 1 (EHV-1) infection, is associated with substantial morbidity and mortality in the horse. As compared to other antiviral drugs, such as acyclovir, ganciclovir has enhanced potency against EHV-1. This study investigated the pharmacokinetics of ganciclovir and its oral prodrug, valganciclovir, in ...
Fawcett Jonathan M - - 2013
In a novel event method directed forgetting task, instructions to Remember (R) or Forget (F) were integrated throughout the presentation of four videos depicting common events (e.g., baking cookies). Participants responded more accurately to cued recall questions (E1) and true/false statements (E2-4) regarding R segments than F segments. This was ...
Michalska Anna - - 2013
INTRODUCTION Diabetic macular edema is a common cause of visual acuity deterioration among patients with diabetes. Laser photocoagulation is a still most common treatment techniques of diabetic retinopathy and diabetic macular edema. OBJECTIVES To assess mean retinal sensitivity among patients with diabetic macular edema before and after laser photocoagulation treatment. ...
Kosicka K - - 2013
11β-Hydroxysteroid dehydrogenase type 2 (11β-HSD2) catalyzes the inactivation of cortisol (F) to cortisone (E) in aldosterone target tissues, thereby protects mineralocorticoid receptor from F. Failure of 11β-HSD2 function is the basis of apparent mineralocorticoid excess, and its mild disturbances are suggested to lead to hypertension. The aim of the study ...
Gulpers Math J M - - 2013
OBJECTIVES: To assess the long-term effects of the EXBELT intervention program, which was designed to reduce belt restraint use and was found to be effective immediately after implementation, after 24 months. DESIGN: Quasi-experimental longitudinal design. SETTING: Thirteen nursing homes: seven assigned to control group and six to intervention group. PARTICIPANTS: A ...
Boonstra Mirjam - - 2013
When starved, Bacillus subtilis cells can enter the developmental program of endospore formation by activation of the master transcriptional regulator Spo0A. Correct chromosome copy number is crucial for the production of mature and fully resistant spores. The production and maintenance of one chromosome for the mother cell and one copy ...
Rhondali Wadih - - 2013
Objective: In a simultaneous care model, patients have concurrent access to both cancer-directed therapies and palliative care. As oncologists play a critical role in determining the need/timing of referral to palliative care programs, their understanding of the service and ability to communicate this with patients is of paramount importance. Our ...
Mavrelos Dimitrios - - 2013
OBJECTIVE: To validate the efficacy and safety of our clinical protocol for expectant management of selected women diagnosed with tubal ectopic pregnancy. METHODS: This was a prospective observational study carried out in the Early Pregnancy Unit (EPU) of a London inner city university teaching hospital from the 1(st) of January ...
Shahare Brigesh - - 2013
Abstract As the use of silver nanoparticles is increasing fast in industry, food, medicines, etc., exposure to silver nanoparticles is increasing in quantity day by day. So, it is imperative to know the adverse effects of silver nanoparticles in man. In this study, we selected mice as an animal model ...
Vaske Jamie - - 2013
The current study uses data from the genetic subsample from the National Longitudinal Study of Adolescent Health (Add Health) in waves I and II (ages of 11-19 and 12-20 respectively) to investigate the interaction of the TaqIA polymorphism and poor parental socialization on changes in adolescent marijuana use. Results reveal ...
Wong Clarence T T - - 2013
Native chemical ligation (NCL) has become the method of choice in synthesizing large or cyclic peptides/proteins. To overcome the limitation of NCL requiring N-terminal cysteine to mediate ligation, a strategy involving thiol-mediated ligation followed by desulfurization has been developed and advanced to realize peptide ligation at other amino acid sites, ...
Sacharczuk Mariusz - - 2013
Experimental evidence suggests that endogenous opioids play an important role in the development of ethanol addiction. In this study, we employed two mouse lines divergently bred for opioid-mediated stress-induced analgesia. In comparison with HA (high analgesia line) mice, LA (low analgesia line) mice, having lower opioid receptor system activity, manifest ...
Gallet Craig A - - 2013
Because of the increased availability of price data over the past 15 years, several studies have estimated the demand for illicit drugs, providing 462 estimates of the price elasticity. Results from estimating several meta-regressions reveal that these price elasticity estimates are influenced by a number of study characteristics. For instance, the ...
Sergi Consolato - - 2013
We report a new and rare case of recurrent anencephaly in a family with no other apparent abnormalities. The karyotypes of the family and all affected subjects were normal. Thorough mutational analyses of VANGL1 of chromosome 1p13.1 and FOXN1 of chromosome 17q11-q12, genes that are associated with phenotypes of the ...
Zhao Xu - - 2013
MicroRNAs (miRNAs) negatively regulate target gene expression by binding to 3'-untranslated region of target mRNA. Single-nucleotide polymorphisms (SNPs) that reside in the miRNA target sites can affect the bindings of miRNAs to mRNAs. Compelling evidence has shown that miRNAs contribute to the etiology of type 2 diabetes (T2DM). We hypothesized ...
Burr M L - - 2013
BACKGROUND: Eczema is common in infancy; there is little evidence about its natural history to adulthood. OBJECTIVES: To study the natural history of eczema from birth to young adult life with particular reference to its relation to atopy. METHODS: A birth cohort of children with atopic family histories was followed ...
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