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Results 201 - 250 of 3056
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Zhai Yanling - - 2013
We report a novel design, based on a combination of lanthanide-doped upconversion nanoparticles and polyoxometalates, for electrically controlled fluorescence switches and sensitive detection of antioxidants in aqueous solution.
Comelon M - - 2013
BACKGROUND: Targiniq®, an oxycodone prolonged-release (PR) formulation combined with the opioid antagonist naloxone PR, aims to prevent opioid-induced constipation without impairing the analgesic efficacy. This has been confirmed during prolonged use in chronic pain or cancer patients. The purpose of our study was to compare clinical effects of oxycodone PR ...
Julia Chantal - - 2013
Inflammation mediates several chronic diseases. Micronutrients can act on inflammation, either through modulating cytokine production or by scavenging by-products of activated white cells. Identifying dietary patterns (DP) reflecting these mechanisms and relating them to inflammation is of interest. The objective of the study was to identify DP specifically associated with ...
Fenenga Christine J - - 2013
The challenges faced by African countries that have pioneered a national health insurance scheme (NHIS) and the lessons learned can be of great value to other countries, contemplating the introduction of such a health financing system. In 2003, Ghana initiated the NHIS to provide access to healthcare for people in ...
Turkowicz Monika Joanna - - 2013
The article discusses analytical problems related to the determination of coenzyme Q10 in biological samples. The assaying of coenzyme Q10 in complex samples, such as plasma, tissues, or food items requires meticulous sample preparation prior to final quantification. The process typically consists of the following steps: deproteinization, extraction, and ultimately ...
Lees Justin G - - 2013
Precise orchestration of actin polymer into filaments with distinct characteristics of stability, bundling, and branching underpins cell migration. A key regulator of actin filament specialization is the tropomyosin family of actin-associating proteins. This multi-isoform family of proteins assemble into polymers that lie in the major groove of polymerized actin filaments, ...
Wang J-J - - 2013
The mammalian cyclin-dependent kinase subunit (Cks) family has two members, Cks1 and Cks2. Overexpression of Cks1 and Cks2 has been reported to be associated with high aggressiveness and poor prognosis in several malignancies, including prostate and hepatocellular carcinomas. However, whether Cks1 and Cks2 are overexpressed in esophageal carcinoma remains uncharacterized. ...
Jørgensen Anne - - 2013
Testicular germ cell tumours (TGCT) of young adults arise from the intratubular precursor, carcinoma in situ (CIS). CIS cells are thought to be developmentally arrested and transformed fetal germ cells that survive through childhood and gain invasive capacity after puberty. Given that germ cell neoplasms arise frequently in undervirilised and ...
Pereira L C - - 2013
Brominated flame retardants are used in various consumer products to increase their resistance to fire and/or high temperatures. Polybrominated Diphenyl Ethers (PBDEs) are representatives of this class and among the most widely used congeners, and BDE-100 is produced on a large scale. There is a lack of toxicological data about ...
O'Kelly Julian - - 2013
In the behavioural assessment of disorders of consciousness (DOC), best practice is for several different assessment tools to be used to encourage a variety of different responses indicative of awareness. Anecdotal evidence suggests a range of musical stimuli may be particularly effective in eliciting responses to guide the assessment process, ...
Wang Ying - - 2013
OBJECTIVE: Idiopathic short stature (ISS) refers to extreme short stature without any diagnostic explanation. Recently, three genome-wide association studies discovered associations between the ZBTB38 and adult height in different populations. Therefore, variations in the ZBTB38 might contribute to ISS. Therefore, one study in Korea population showed that ZBTB38 gene was ...
Fisher H L - - 2013
BACKGROUND: Childhood psychotic symptoms have been used as a subclinical phenotype of schizophrenia in etiological research and as a target for preventative interventions. However, recent studies have cast doubt on the specificity of these symptoms for schizophrenia, suggesting alternative outcomes such as anxiety and depression. Using a prospective longitudinal birth ...
Sfaihi Lamia - - 2013
The aim of this study is to review the cases of arterial ischemic stroke (AIS) in children in our department to evaluate the clinical and neuroimaging features, the etiologies and the treatment. This study retrospectively reviewed the records of all children aged between 1 month and 16 years who were admitted ...
Benzler Jonas - - 2013
The hypothalamus has been identified to be a main insulin target tissue for regulating normal body weight and glucose metabolism. Recent observations suggest that c- Jun-N-terminal kinase (JNK)-signalling plays a crucial role in the development of obesity and insulin resistance since neuronal JNK-1 ablation in the mouse prevented high fat ...
Momose Kenji - - 2013
Necl-2/CADM1 is down-regulated by the promoter hypermethylation and/or the loss of heterozygosity at chromosome 11q23.2 in many types of cancers and serves as a tumor suppressor by interacting in cis with ErbB3 and suppressing the ligand-induced ErbB2/ErbB3 signaling for cell movement and death. However, the incidence of these epigenetic and ...
Trussardi Fayh Ana Paula - - 2013
Evidence supports an important contribution of abdominal obesity and inflammation to the development of insulin resistance (IR) and CVD. Weight loss in obese individuals can reduce inflammation and, consequently, IR, but the role of training remains unclear. The aim of this study was to evaluate the effects of body weight ...
Stavri Simona - - 2013
Dermal bone is an important component of the teleost fins, and its ability to regenerate after fin amputation appears to be unlimited. The organic bone matrix contain type I collagen fibers, proteoglycans enriched in chondroitin sulfate, and noncollagenous matrix protein such as osteocalcin, osteopontin, and osteonectin. These molecules are synthesized ...
Liu Guanshu - - 2013
Chemical exchange saturation transfer (CEST) has emerged as a novel MRI contrast mechanism that is well suited for molecular imaging studies. This new mechanism can be used to detect small amounts of contrast agent through the saturation of rapidly exchanging protons on these agents, allowing a wide range of applications. ...
Morona Judy K - - 2013
BACKGROUND: Effective off-loading is considered to be an important part of the successful clinical management of people with diabetes, as between 15% and 25% of them will suffer from a foot ulcer during their lifetime. The aim of this systematic review is to investigate the safety and effectiveness of different ...
Josuttis Melanie - - 2013
Strawberry cultivars grown at different locations in Europe showed genotype- and environment-dependent variation in total phenol and anthocyanin content. This study focused on the compositional diversity of tannins from these cultivars using a high-through-put liquid-chromatography-mass-spectrometric (LCMS) technique. Cultivars grown in Germany showed differences in the relative amounts of proanthocyanidins (PACs) ...
Sarkar Siddharth - - 2013
Smokeless tobacco use is a major health issue but has received less attention in craving research. The present non-funded study aimed to assess craving associated with smokeless tobacco compared to smoked forms. Forty-eight nicotine dependent male subjects attending a deaddiction center in India were recruited. The subjects were exposed to ...
Cosmidis J - - 2013
Micrometer-sized spherical and rod-shaped forms have been reported in many phosphorites and often interpreted as microbes fossilized by apatite, based on their morphologic resemblance with modern bacteria inferred by scanning electron microscopy (SEM) observations. This interpretation supports models involving bacteria in the formation of phosphorites. Here, we studied a phosphatic ...
Liu Xiao-Jin - - 2013
Hypertrophic scarring is a common disease affecting millions of people around the world, but there are currently no satisfactory drugs to treat the disease. Exaggerated inflammation and mechanical stress have been shown to be two main mechanisms of excessive fibrotic diseases. Here we found that a benzopyran natural product, xiamenmycin, ...
Hodak Emmilia - - 2013
Studies of associated cancer in patients with mycosis fungoides (MF) have focused primarily on secondary cancers in North American and European populations. This study investigated the association between MF and malignancies, anxiety and depression in the Israeli population. Data on Israeli patients with MF and age- and gender-matched controls were ...
Hong Kyung-Won - - 2013
Low albumin:globulin (A/G) ratios are associated with vascular adverse events, nephrotic syndrome and autoimmune disease. Genome-wide association studies (GWASs) have been identifying genetic variants associated with total serum protein, serum albumin and globulins, but A/G ratio has never been considered the target phenotype. To identify the genetic basis of the ...
Chung W S - - 2013
Factors related to sexual arousal are different in men and women. The conditions for women to become aroused are more complex. However, the conventional audio-visual stimulation (AVS) materials used to evaluate sexual arousal are universal. In the present study, we investigated sexual differences in the response to different types of ...
Liu Chao - - 2013
The oxidant controlled palladium catalysed selective oxidation of primary alcohols to aldehydes or esters was investigated. The electronic properties of the benzylic alcohols and the structure of the oxidant are both important factors in controlling the selectivity between aldehydes and esters. A covalent benzyl ligand derived from BnCl provides η(3) ...
Hayashi Tsuyoshi - - 2013
BACKGROUND AND AIM: Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is an established diagnostic method for patients with suspected pancreatic ductal carcinoma (PDC). Rapid on-site evaluation (ROSE) has been reported to improve the accuracy. However, an on-site cytopathologist is not routinely available in many institutions. One of the solutions may be ...
Slusarz Magdalena J - - 2013
Vasopressin and oxytocin receptors belong to the superfamily of G protein-coupled receptors and play an important role in many physiological functions. They are also involved in a number of pathological conditions being important drug targets. In this work, four vasopressin analogues substituted at position 2 with 3,3'-diphenylalanine have been docked ...
Cabrales Antonio - - 2013
This paper studies price determination in pharmaceutical markets using data for 25 countries, 6 years, and a comprehensive list of products from the MIDAS IMS database. A key finding is that the USA has prices that are not significantly higher than those of countries with similar income levels, especially those that ...
Mognetti Barbara - - 2013
Prostate cancer frequently metastasizes to the bone, and the interaction between cancer cells and bone microenvironment has proven to be crucial in the establishment of new metastases. Bone marrow mesenchymal stem cells (BM-MSCs) secrete various cytokines that can regulate the behaviour of neighbouring cell. However, little is known about the ...
Nasit Jitendra Gordhanbhai - - 2013
Solid pseudopapillary tumor (SPT) is an uncommon pancreatic neoplasm with low malignant potential. It occurs predominantly in young women. It is very rare in males and nonrelated pediatrics. In children, SPT commonly present as abdominal mass and pain. A 10-year-old male presented with progressively growing palpable tumor in upper abdomen. ...
Martino Alessandro - - 2013
The exposure to pesticides and toxic compounds in xenobiotic transport and metabolism genes has been shown to affect risk of developing multiple myeloma (MM). Therefore, we hypothesized that genetic variations in xenobiotic transport and metabolism regulator genes PXR (NR1I2) and CAR (NR1I3) could determine a difference in MM susceptibility. Ten ...
Bourne David G - - 2013
Coral reefs provide habitat for an array of marine invertebrates that host symbiotic microbiomes. Photosynthetic symbionts including Symbiodinium dinoflagellates and diatoms potentially influence the diversity of their host-associated microbiomes by releasing carbon-containing photosynthates and other organic compounds that fuel microbial metabolism. Here we used 16S ribosomal RNA (rRNA) gene amplicon ...
Gambichler T - - 2013
We read with great interest the paper of Edmonds et al. (1) who observed that men with penile lichen sclerosus (PLS) have significantly increased extracellular matrix protein 1 (ECM1) serum levels when compared to healthy controls (HC). Similar results were previously found in women with vulvar LS (VLS).(2) Edmonds et ...
Steyer Véronique - - 2013
Once considered potential sources of danger, generating industrial risks, companies are now viewed as indispensable partners in preparing risk responses. However, this shift raises the crucial question of the coordination between the various actors, especially as the literature - particularly on public-private partnerships (PPPs) and inter-organisational collaborations - highlights multiple ...
Kagiyama Megumi - - 2013
Strigolactones (SLs) are plant hormones that inhibit shoot branching. DWARF14 (D14) inhibits rice tillering and is an SL receptor candidate in the branching inhibition pathway, whereas the close homologue DWARF14-LIKE (D14L) participates in the signaling pathway of karrikins (KARs), which are derived from burnt vegetation as smoke stimulants of seed ...
Scott Daniel J - - 2013
ABSTRACT: BACKGROUND: The Multiparameter Intelligent Monitoring in Intensive Care II (MIMIC-II) database is a free, publicresource for intensive care research. The database was officially released in 2006, and has attracted agrowing number of researchers in academia and industry. We present the two major software toolsthat facilitate accessing the relational database: ...
Jang Ji Woong - - 2013
BACKGROUND AND AIM: Comparatively little is known about acute pancreatitis or acute recurrent pancreatitis (AP/ARP) with intraductal papillary mucinous neoplasm of the pancreas (IPMN) as the causative lesion although there have been many reports about the malignant potential of IPMN as a premalignant lesion. METHODS: From 2000 to 2008, in ...
Whiteoak Christopher J - - 2013
An aluminium complex based on an amino triphenolate ligand scaffold shows unprecedented high activity (initial TOFs up to 36,000 h-1), substrate scope and functional group tolerance in the formation of highly functional organic carbonates prepared from epoxides and CO2. The developed catalytic protocol is further characterized by low catalyst loadings ...
Tunca Yusuf - - 2013
The coincidence of trisomy 21 and a structural rearrangement is very rare, and even it has not been reported as a prenatal diagnosis yet. In this article, we present an autosomal translocation carrier fetus with trisomy 21: 47,XX,+21, t(3;8)(p21;q24). Although the coincidence of reciprocal translocation and trisomy may be seen ...
Vera-Ramirez Laura - - 2013
Liver diseases pose a major medical problem worldwide and a wide variety of herbs have been studied for the management of liver-related diseases. In this respect, curcumin has long been used in traditional medicine, and in recent years it has been the object of increasing research interest. In combating liver ...
Orihuela Ruben - - 2013
Abstract The carcinogen inorganic arsenic (iAs) undergoes biomethylation (BMT) in some cells. The methylated metabolite, monomethylarsonous (MMA(3+)), may cause oxidative DNA damage (ODD). With chronic iAs exposure, BMT-competent cells show ODD while BMT-deficient do not. To further define these events, we studied ODD produced by acute iAs or MMA(3+) in ...
Riek Alexander - - 2013
A large number of analyses have examined how basal metabolic rate (BMR) is affected by body mass in mammals. By contrast, the critical ambient temperatures that define the thermo-neutral zone (TNZ), in which BMR is measured, have received much less attention. We provide the first phylogenetic analyses on scaling of ...
Sariyildiz M A - - 2013
The aim of this study was to explore the impact of ankylosing spondylitis (AS) and the disease-related variables, psychological status and the quality of life on the female patients' sexual function measured according to the Female Sexual Function Index (FSFI). Thirty-seven sexually active female AS patients and 33 healthy controls ...
Bai Yu - - 2013
AIM: Recently Gastroesophageal Reflux Disease Questionnaire (GerdQ) has been developed for diagnosis of GERD. However, no study investigated its value in real-world practice. This study aimed to investigate whether GerdQ can be used for diagnosis of GERD in China. METHODS: A national multicenter survey was undertaken; all patients who underwent ...
Sumathipala Athula - - 2013
The Sri Lankan Twin Registry (SLTR), established in 1997, is a unique resource for twin and genetic research in a low- and middle-income country (LMIC). It comprises of a volunteer cohort of 14,120 twins (7,060 pairs) and 119 sets of triplets, and a population-based cohort of 19,040 (9,520 pairs) twins ...
Nader Ingo W - - 2013
Knowledge about suicide postvention (KSPV) is an important distal outcome in the evaluation of suicide prevention programs that focus on the bereaved. However, most scales are specifically tailored to the evaluation study in question and psychometric properties are often unsatisfactory. Therefore, we developed the KSPV scale. Scale properties were investigated ...
Wang Jiang - - 2013
Abstract Objective: We investigated the myocardial protective effect of sevoflurane in patients receiving off-pump coronary artery bypass grafting (OPCABG) and the role of brain natriuretic peptide (BNP). Design: Forty-eight patients receiving elective OPCABG were randomly assigned to a control group, and 0.75 MAC, 1.0 MAC and 1.5 MAC sevoflurane groups. ...
Behari Professor Madhuri - - 2013
Abstract Platelets play an important role in a variety of disorders viz; cardiovascular, psychosomatic, psychiatric, thrombosis, HIV/AIDS in addition to various neurodegenerative diseases (NDD). Recent evidence indicates that platelet react to diverse stressors thereby offering an interesting vantage point for understanding their potential role in contemporary medical research. This review ...
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