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Benzler Jonas - - 2013
The hypothalamus has been identified to be a main insulin target tissue for regulating normal body weight and glucose metabolism. Recent observations suggest that c- Jun-N-terminal kinase (JNK)-signalling plays a crucial role in the development of obesity and insulin resistance since neuronal JNK-1 ablation in the mouse prevented high fat ...
Momose Kenji - - 2013
Necl-2/CADM1 is down-regulated by the promoter hypermethylation and/or the loss of heterozygosity at chromosome 11q23.2 in many types of cancers and serves as a tumor suppressor by interacting in cis with ErbB3 and suppressing the ligand-induced ErbB2/ErbB3 signaling for cell movement and death. However, the incidence of these epigenetic and ...
Yazar Seyhan - - 2013
ABSTRACT Purpose: The Raine Eye Health Study (REHS) was conceived to determine the prevalence of and risk factors for eye disease in young adults, and to characterize ocular biometric parameters in a young adult cohort. This article summarizes the rationale and study design of REHS and outlines the baseline prevalence ...
Winter Torsten - - 2013
We analyzed prevalence and stability of attitudes endorsing sexual abstinence ideals from late adolescence into early adulthood and studied associations of these attitudes with religiosity and alcohol abstinence in a sexually liberal Nordic society. Our population-based sample of Finnish twins permitted comparisons of co-twins concordant for religiosity but discordant for ...
Verhaegh Bas P M - - 2013
BACKGROUND: Pain is a major problem for chronic pancreatitis (CP) patients. Unfortunately, medical therapy often fails. Endoscopic and surgical treatments are invasive, and results vary. Percutaneous radiofrequency ablation of the splanchnic nerves (RFSN) is a relatively new and minimally invasive procedure for treatment of intractable pain in CP patients. MATERIALS ...
García-Gutiérrez Laura L Instituto de Hortofruticultura Subtropical y Mediterránea 'La Mayora'-IHSM-UMA-CSIC, Departamento de Microbiología, Universidad de Málaga, Bulevar Louis Pasteur 31-Campus Universitario de Teatinos, 29071 Málaga, - - 2013
Biological control of plant diseases has gained acceptance in recent years. Bacillus subtilis UMAF6639 is an antagonistic strain specifically selected for the efficient control of the cucurbit powdery mildew fungus Podosphaera fusca, which is a major threat to cucurbits worldwide. The antagonistic activity relies on the production of the antifungal compounds ...
Romlin Birgitta S - - 2013
OBJECTIVE: Earlier detection of coagulopathy in pediatric cardiac surgery patients. AIM: To determine whether thromboelastometry (TEM) analysis before weaning from cardiopulmonary bypass (CPB) and hemoconcentration is predictive of post-CPB results and whether analysis of clot firmness already after 10 min yields reliable results. BACKGROUND: Cardiac surgery with CPB induces a coagulopathy ...
Moran B - - 2013
Non-melanoma skin cancers on the nose frequently present to dermatology for surgical excision. This anatomical area has an excellent vascular supply and, consequently, increased intra-operative bleeding (Fig. 1 (a)). Pinching the nasal tip to control bleeding is commonly used, however this can be uncomfortable for the patient because the nasal ...
González-Curbelo Miguel Ángel - - 2013
In this manuscript, a dispersive SPE method based on the use of multiwalled carbon nanotubes has been developed for the determination of 15 organophosphorus pesticides residues including some of their metabolites (disulfoton sulfoxide, ethoprophos, cadusafos, dimethoate, terbufos, disulfoton, chlorpyrifos-methyl, malaoxon, fenitrothion, pirimiphos-methyl, malathion, chlorpyrifos, terbufos sulfone, disulfoton sulfone, and fensulfothion) ...
Antúnez Lucía - - 2013
The aim of this work was to evaluate consumer visual processing of food labels when evaluating the salt content of pan bread labels and to study the influence of label design and nutritional labelling format on consumer attention. A total of 16 pan bread labels, designed according to a full ...
Kaganovich Natalya N Department of Speech, Language, and Hearing Sciences, Purdue University, 500 Oval Drive, West Lafayette, IN 47907-2038, USA. - - 2013
Using electrophysiology, we have examined two questions in relation to musical training - namely, whether it enhances sensory encoding of the human voice and whether it improves the ability to ignore irrelevant auditory change. Participants performed an auditory distraction task, in which they identified each sound as either short (350 ...
Umesawa Mitsumasa - - 2013
Dietary behavior can worsen or prevent hypertension. However, data on the association between dietary behavior and the risk of hypertension in Asians are limited. The aim of this study was to determine these associations in Japanese male workers. We conducted a prospective study of 30-71-year-old Japanese male workers in Osaka, ...
Gopinath Bamini - - 2013
AIMS: Dietary modifications may play an important role in the prevention of diabetes. We aimed to assess the temporal association between diet quality and both impaired fasting glucose and Type 2 diabetes among older adults. METHODS: A total of 2564 participants aged 49+ years at baseline were examined between 1992 and ...
Gäbler Karoline - - 2013
The Janus kinase 2 mutant V617F occurs with high frequency in myeloproliferative neoplasms. Further mutations affecting the Janus kinase family have been discovered mostly in leukaemias and in myeloproliferative neoplasms. Owing to their involvement in neoplasia, inflammatory diseases and in the immune response, Janus kinases are promising targets for kinase ...
Pal Sujoy - - 2013
BACKGROUND: In patients with extrahepatic portal venous obstruction (EHO), death is usually due to variceal bleeding. This is more so in developing countries where there are a lack of tertiary healthcare facilities and blood banks. Prophylactic operations in cirrhotics have been found to be deleterious. In contrast, patients with EHO ...
Tseng Hubert - - 2013
A longstanding goal in biomedical research has been to create organotypic co-cultures that faithfully represent native tissue environments. There is presently great interest in representative culture models of the lung, which is a particularly challenging tissue to recreate in vitro. This study used magnetic levitation in conjunction with magnetic nanoparticles ...
Kalthoff Daniel - - 2013
Functional connectivity networks derived from resting-state functional MRI (rsfMRI) have received increasing interest to further our understanding of brain function. The anesthesia in rodent models may influence the interpretation and comparison of results from functional connectivity MRI (fcMRI). More research is required on this aspect. In this study, we investigated ...
Less Robert J - - 2013
Structural and in situ NMR spectroscopic studies show that N-H deprotonation, B-N bond cleavage and B-N bond formation can occur in the stoichiometric and catalytic reactions of LiAlH(4) with Me(2)NHBH(3).
van der Heijden Laila B - - 2013
OBJECTIVES: In fetal tachycardia pharmacologic therapy with digoxin, flecainide and sotalol has been reported to be effective. In a recent retrospective multicentre study sotalol was considered to be less effective than the others in fetal SVT. The aim of this study is to re-evaluate the efficacy and safety of maternally ...
Handl S - - 2013
Previous work has shown obesity to be associated with changes in intestinal microbiota. While obesity is common in dogs, limited information is available about the role of the intestinal microbiota. The aim of this study was to investigate if alterations in the intestinal microbiota may be associated with canine obesity. ...
Loite Ulvi - - 2013
The corticotrophin-releasing hormone-proopiomelano-cortin (CRH-POMC) system in the skin coordinates pigmentation and the immune response. The aim of this study was to evaluate the regulatory role of the neuroendocrine system in the pathogenesis of psoriasis. Using quantitative real-time-PCR, mRNA expression levels of 15 genes related to the CRH-POMC system were measured ...
Savchev Stefan - - 2013
OBJECTIVE: To evaluate the 2-year neurodevelopmental outcome of full-term, small-for-gestational-age (SGA) newborns with normal placental function, according to current criteria based on umbilical artery Doppler. PATIENTS AND METHODS: A cohort of consecutive full-term, SGA newborns with normal prenatal umbilical artery Doppler was compared with a group of full-term, appropriate-for-gestational-age (AGA) ...
Gieler Uwe - - 2013
The terminology, classification, diagnosis and treatment of self-inflicted dermatological lesions are subjects of open debate. The present study is the result of various meetings of a task force of dermatologists, psychiatrists and psychologists, all active in the field of psychodermatology, aimed at clarifying the terminology related to these disorders. A ...
Isbell Forest - - 2013
Although nutrient enrichment frequently decreases biodiversity, it remains unclear whether such biodiversity losses are readily reversible, or are critical transitions between alternative low- and high-diversity stable states that could be difficult to reverse. Our 30-year grassland experiment shows that plant diversity decreased well below control levels after 10 years of chronic ...
Wang H H Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, - - 2013
Concerns about the geometric accuracy of MRI in radiation therapy (RT) have been present since its invention. Although modern scanners typically have system levels of geometric accuracy that meet requirements of RT, subject-specific distortion is variable, and methods to in vivo assess and control patient-induced geometric distortion are not yet ...
Yasmin Nighat - - 2013
The epithelial signaling protein and transcriptional regulator β-catenin has recently been implicated in hematopoietic dendritic cell (DC) differentiation as well as in DC-mediated tolerance. We here observed that epidermal Langerhans cells (LCs) but not interstitial/dermal DCs express detectable β-catenin. LCs are unique among the DC family members in that LC ...
Daly Susan M - - 2013
The assessment of vascular dynamics has been shown to yield both qualitative and quantitative metrics and thus play a pivotal role in the diagnosis and prognosis of various diseases, which may manifest as microcirculatory irregularities. Optical Coherence Tomography (OCT) is an established imaging modality which utilises the principle of optical ...
Chase Elaine - - 2013
This article considers the relevance of the notion of ontological security - a sense of order, stability, routine and predictability to life - to contemporary conceptualisations of wellbeing. Drawing on in-depth interviews with unaccompanied young people seeking asylum in the UK, it demonstrates how a positive sense of self and ...
Lee Hyunhwa - - 2013
This paper explored the relationships between parental alcoholism, sense of belonging, resilience, and depressive symptoms among Koreans in the U.S. Data from 206 Koreans (Mean age = 28.4 years; 59.8% females) living in a Midwestern state were collected in 2009, using a web-based survey, which included Children of Alcoholic Screening Test, ...
Ray Sutapa S Department of Internal Medicine, Endocrinology Division, University of Texas Medical Branch, Galveston, Texas 77555-1060, USA. - - 2013
The molecular mechanisms behind the pathogenesis of postburn hypertrophic scar (HS) remain unclear. Here, we investigate the role of the IL-6 trans-signaling-signal transducer and activator of transcription (STAT)3 pathway in HS fibroblasts (HSFs) derived from post-burn HS skin. HSF showed increased Tyr 705 STAT3 phosphorylation compared with normal fibroblast (NF) ...
Wong Clarence T T - - 2013
Native chemical ligation (NCL) has become the method of choice in synthesizing large or cyclic peptides/proteins. To overcome the limitation of NCL requiring N-terminal cysteine to mediate ligation, a strategy involving thiol-mediated ligation followed by desulfurization has been developed and advanced to realize peptide ligation at other amino acid sites, ...
Sacharczuk Mariusz - - 2013
Experimental evidence suggests that endogenous opioids play an important role in the development of ethanol addiction. In this study, we employed two mouse lines divergently bred for opioid-mediated stress-induced analgesia. In comparison with HA (high analgesia line) mice, LA (low analgesia line) mice, having lower opioid receptor system activity, manifest ...
Gallet Craig A - - 2013
Because of the increased availability of price data over the past 15 years, several studies have estimated the demand for illicit drugs, providing 462 estimates of the price elasticity. Results from estimating several meta-regressions reveal that these price elasticity estimates are influenced by a number of study characteristics. For instance, the ...
Sergi Consolato - - 2013
We report a new and rare case of recurrent anencephaly in a family with no other apparent abnormalities. The karyotypes of the family and all affected subjects were normal. Thorough mutational analyses of VANGL1 of chromosome 1p13.1 and FOXN1 of chromosome 17q11-q12, genes that are associated with phenotypes of the ...
Zhao Xu - - 2013
MicroRNAs (miRNAs) negatively regulate target gene expression by binding to 3'-untranslated region of target mRNA. Single-nucleotide polymorphisms (SNPs) that reside in the miRNA target sites can affect the bindings of miRNAs to mRNAs. Compelling evidence has shown that miRNAs contribute to the etiology of type 2 diabetes (T2DM). We hypothesized ...
Yonezawa Tetsu - - 2013
Surface-assisted laser desorption/ionization time-of-flight mass spectrometry (SALDI-TOF-MS) using GaP nanoparticles (NPs) prepared by a gas evaporation method was investigated on poly(ethylene glycol)s (PEGs). The mass spectra of PEG and survival yield measurements suggested that larger GaP NPs have a quite high soft ionization ability.
Pinton Giulia - - 2013
Malignant Pleural Mesothelioma (MMe) is a rare but increasingly prevalent, highly aggressive cancer with poor prognosis. The aetiology of MMe is essentially a function of previous exposure to asbestos fibres, which are considered to be an early-stage carcinogen. Asbestos is toxic to human mesothelial cells (HMCs), that activate the nuclear ...
Xu Y - - 2013
The performance of a fast optical computed tomography (CT) scanner based on a point laser source, a small area photodiode detector, and two optical-grade Fresnel lenses is evaluated. The OCTOPUS™-10× optical CT scanner (MGS Research Inc., Madison, CT) is an upgrade of the OCTOPUS™ research scanner with improved design for faster motion ...
Rochon Paula A - - 2013
OBJECTIVES: To understand how drug therapy differently affects older women and men. DESIGN: Population-based, retrospective cohort study. SETTING: Ontario, Canada. PARTICIPANTS: Twenty-one thousand five hundred twenty-six older adults (13,760 women, 7,766 men) with dementia newly started on oral atypical antipsychotic therapy between April 1, 2007, and March 1, 2010. MEASUREMENTS: ...
Burr M L - - 2013
BACKGROUND: Eczema is common in infancy; there is little evidence about its natural history to adulthood. OBJECTIVES: To study the natural history of eczema from birth to young adult life with particular reference to its relation to atopy. METHODS: A birth cohort of children with atopic family histories was followed ...
Kandeel Nahed Attia - - 2013
Physical restraints are commonly used in intensive care units to reduce the risk of injury and ensure patient safety. However, there is still controversy regarding the practice of physical restraints in such units. The purpose of this study was to investigate the practices of physical restraints among critical care nurses ...
Li Xinrong - - 2013
ABSTRACT: BACKGROUND: Catgut implantation at acupoints has been used in China to treatment allergic rhinitis (AR) for a long time. However, its efficacy and safety in the treatment of AR is controversial due to the poor quality of the clinical trial of this therapy. This study aims to identify whether ...
Jiménez-Pavón David - - 2013
OBJECTIVE: To analyze the association between objectively assessed physical activity (PA) and markers of insulin resistance (IR) in European adolescents and to examine whether the association of objectively assessed PA and markers of IR is modified by cardiorespiratory fitness (CRF). METHODS: A cross-sectional study at school setting was conducted in ...
Korzeniecka-Kozerska Agata - - 2013
Abstract Objective. Myelomeningocele is the most common physically disabling birth defect in humans. It is caused by the failure of the neural tube to close and is most common in the lumbosacral area. Because of associated neurogenic bladder dysfunction, children with myelomeningocele have an increased risk of urinary tract infections ...
Morandini Piero - - 2013
Which factors limit metabolite accumulation in plant cells? Are theories on flux control effective at explaining the results? Many biotechnologists cling to the idea that every pathway has a rate limiting enzyme and target such enzymes first in order to modulate fluxes. This often translates into large effects on metabolite ...
Stessman Jochanan - - 2013
OBJECTIVES: To examine the relationship between resting pulse rate (RPR) and longevity in individuals aged 70 to 90. DESIGN: The Jerusalem Longitudinal Cohort Study (1990-2010) is a prospective longitudinal study of a representative cohort born in 1920-21. SETTING: Home-based comprehensive assessment in 1990, 1998, and 2005. PARTICIPANTS: Individuals aged 70 ...
Serna Eva - - 2013
BACKGROUND AND AIM: Increased basal release of nitric oxide (NO) in the splanchnic circulation contributes to elevated plasma levels of NO observed in decompensated cirrhosis. We evaluated in rat mesenteric arteries whether the differences in basal release of NO, revealed by asymmetric dimethylarginine (ADMA)- and N(G) -nitro-L-arginine methyl ester (L-NAME)-induced ...
Thyssen J P - - 2013
Ichthyosis vulgaris is caused by loss-of-function mutations in the filaggrin gene (FLG) and characterized clinically by xerosis, scaling, keratosis pilaris, palmar and plantar hyperlinearity, and a strong association with atopic disorders. According to published studies presented in this review article, FLG mutations are observed in approximately 7.7% of Europeans and ...
Zhai Yanling - - 2013
We report a novel design, based on a combination of lanthanide-doped upconversion nanoparticles and polyoxometalates, for electrically controlled fluorescence switches and sensitive detection of antioxidants in aqueous solution.
Comelon M - - 2013
BACKGROUND: Targiniq®, an oxycodone prolonged-release (PR) formulation combined with the opioid antagonist naloxone PR, aims to prevent opioid-induced constipation without impairing the analgesic efficacy. This has been confirmed during prolonged use in chronic pain or cancer patients. The purpose of our study was to compare clinical effects of oxycodone PR ...
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