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Green Mandy C - - 2013
The work in this article describes a spectral signature for the detection of a C(α) radical damaged peptide, which should enable the use of infrared spectroscopic methods to directly monitor oxidative events. Spectra for radical damaged peptides are computed with ab initio methods. The amide bands A, I, II, and ...
Perrin Andrea - - 2013
This review aims to introduce the chemistry of low dosage inhibitors of clathrate hydrate formation within the context of their role in the oil and gas industry. The review covers both kinetic hydrate inhibitors and anti-agglomerants from the point of view of structure-function relationships, focussing on recent refinements in mechanistic ...
Kojima Akira - - 2013
BACKGROUND/AIMS: The Japan Society for Dialysis Therapy established "Guidelines for the Treatment of Hepatitis C Virus Infection in Dialysis Patients". We evaluated the status of HCV infection and the treatment of hemodialysis patients in Gunma prefecture. METHODS: Questionnaires concerning the infection rate, recognition of the guidelines, and treatment status were ...
Yazar Seyhan - - 2013
ABSTRACT Purpose: The Raine Eye Health Study (REHS) was conceived to determine the prevalence of and risk factors for eye disease in young adults, and to characterize ocular biometric parameters in a young adult cohort. This article summarizes the rationale and study design of REHS and outlines the baseline prevalence ...
Winter Torsten - - 2013
We analyzed prevalence and stability of attitudes endorsing sexual abstinence ideals from late adolescence into early adulthood and studied associations of these attitudes with religiosity and alcohol abstinence in a sexually liberal Nordic society. Our population-based sample of Finnish twins permitted comparisons of co-twins concordant for religiosity but discordant for ...
Verhaegh Bas P M - - 2013
BACKGROUND: Pain is a major problem for chronic pancreatitis (CP) patients. Unfortunately, medical therapy often fails. Endoscopic and surgical treatments are invasive, and results vary. Percutaneous radiofrequency ablation of the splanchnic nerves (RFSN) is a relatively new and minimally invasive procedure for treatment of intractable pain in CP patients. MATERIALS ...
Romlin Birgitta S - - 2013
OBJECTIVE: Earlier detection of coagulopathy in pediatric cardiac surgery patients. AIM: To determine whether thromboelastometry (TEM) analysis before weaning from cardiopulmonary bypass (CPB) and hemoconcentration is predictive of post-CPB results and whether analysis of clot firmness already after 10 min yields reliable results. BACKGROUND: Cardiac surgery with CPB induces a coagulopathy ...
Moran B - - 2013
Non-melanoma skin cancers on the nose frequently present to dermatology for surgical excision. This anatomical area has an excellent vascular supply and, consequently, increased intra-operative bleeding (Fig. 1 (a)). Pinching the nasal tip to control bleeding is commonly used, however this can be uncomfortable for the patient because the nasal ...
González-Curbelo Miguel Ángel - - 2013
In this manuscript, a dispersive SPE method based on the use of multiwalled carbon nanotubes has been developed for the determination of 15 organophosphorus pesticides residues including some of their metabolites (disulfoton sulfoxide, ethoprophos, cadusafos, dimethoate, terbufos, disulfoton, chlorpyrifos-methyl, malaoxon, fenitrothion, pirimiphos-methyl, malathion, chlorpyrifos, terbufos sulfone, disulfoton sulfone, and fensulfothion) ...
Antúnez Lucía - - 2013
The aim of this work was to evaluate consumer visual processing of food labels when evaluating the salt content of pan bread labels and to study the influence of label design and nutritional labelling format on consumer attention. A total of 16 pan bread labels, designed according to a full ...
Cinta Pinzaru Simona - - 2013
An interdisciplinary approach employing functionalized nanoparticles and ultrasensitive spectroscopic techniques is reported here to track the molecular changes in early stage of malignancy. Melanoma tissue tracking at molecular level using both labelled and unlabelled silver and gold nanoparticles has been achieved using surface enhanced Raman scattering (SERS) technique. We used ...
Hattori Mitsuru - - 2013
We developed bioluminescence probes to detect quantitative interaction of GPCRs with arrestin isoforms β-arrestin1 and β-arrestin2 based on split luciferase complementation. Time-dependent GPCR-β-arrestin interactions showed two-types of remarkable variations that were consistent with a classification of GPCR classes. Positive charge residues in serine clusters located at the C-terminal region of ...
Yurt Lambrecht Fatma - - 2013
Abstract Bombesin and its derivatives exhibit a high affinity for gastrin-releasing peptide receptor (GRPr), which is over-expressed in a variety of human cancers (prostate, pancreatic, lung, etc.). The aim of this study was to investigate the in vitro potential of the hydrazinonicotinamide (HYNIC)-Q-Litorin. (99m)Tc labeling was performed by using different ...
Kallem Raja Reddy - - 2013
A highly sensitive and specific LC-ESI-MS/MS method has been developed and validated for simultaneous quantification of felodipine (FDP) and metoprolol (MPL) in rat plasma (50 μL) using phenacetin as an internal standard (IS) as per the FDA guidelines. Liquid-liquid extraction method was used to extract the analytes and IS from rat ...
Gosmain Yvan - - 2013
Type 2 diabetes is one of the most common diseases affecting 5 to 10% of the population in most countries; the progression of its prevalence is constant over the last 50 years in all countries of the world creating a major public health problem in term of disease management and ...
Laufer Yocheved - - 2013
There is still unsettled controversy regarding the optimal neuromuscular electrical stimulation (NMES) parameters that will induce the strongest contractions with minimal discomfort. The purpose of this study was to determine whether the introduction of an interphase interval (IPI) interposed within the two phases of biphasic pulses will affect sensory and ...
Lesniak Aleksandra B - - 2013
BACKGROUND: This retrospective cohort study was designed to assess the impact of intrathecal morphine compared with no intrathecal morphine on blood loss and on hemodynamic stability during surgery for pediatric idiopathic scoliosis correction. METHODS: A retrospective review was done of 256 anesthetic charts who underwent scoliosis surgery between January 1993 ...
García Josefa Bernat - - 2013
Non-melanoma skin cancer (NMSC) is the most frequent malignancy in organ transplant recipients. The aetiology of NMSC after transplant is multifactorial. The aim of this study was to determine the clinical and environmen-tal factors involved in the development of NMSC in a Spanish kidney transplant population from the Mediterranean region. ...
Vogt Isabelle - - 2013
Fire blight is a destructive bacterial disease caused by Erwinia amylovora affecting plants in the family Rosaceae, including apple. Host resistance to fire blight is present mainly in accessions of Malus spp. and is thought to be quantitative in this pathosystem. In this study we analyzed the importance of the ...
Cruz Célia F - - 2013
Human hair has an important and undeniable relevance in society due to its important role in visual appearance and social communication. Hair is mainly composed of structural proteins, mainly keratin and keratin associated proteins, and lipids. Herein, we report a comprehensive study of the content and distribution of the lipids ...
Qin Andong - - 2013
Recent evidence showed that limited activation of PI3K/Akt pathway was critical for induction and function sustainment of CD4(+) Foxp3(+) regulatory T cells (Tregs). However, the underlying mechanism remains largely unknown. In this study, we reported that miR-126 was expressed in mouse and human Tregs. Further study showed that silencing of ...
Fustero Santos - - 2013
A gold-catalyzed tandem intramolecular hydroamination-formal aza-Diels-Alder reaction of propargylic amino esters is described. The overall process leads to the formation of a tetracyclic framework as a single diastereoisomer, with the creation of four bonds and five stereocenters.
Tsuji Takeshi - - 2013
Results of very recent studies have shown that laser irradiation (LI) of colloidal nanoparticles (NPs) using a non-focused laser beam at moderate fluence transforms the NPs to submicron-sized spherical particles (SMPs). For this study, we applied this technique to prepare gold SMPs from source gold NPs prepared by laser ablation ...
Petersen B - - 2013
BACKGROUND: A great number of journeys to sunny destinations are sold to the Danish population every year. We suspect that this travel considerably increases personal annual ultraviolet radiation (UVR) exposure-dose. This is important because such exposure is the main cause of skin cancer, and studies have shown a correlation between ...
Stadler M - - 2013
BACKGROUND: In patients with type 1 diabetes mellitus (T1DM), insulin is usually replaced systemically (subcutaneously) and not via the physiologic portal route. According to previous studies, the liver's capacity to store glycogen is reduced in T1DM patients, but it is unclear whether this is due to hyperglycaemia, or whether the ...
Karaman Yucel - - 2013
SUMMARY: Following a propofol anesthetic, a 5-year-old girl with lower extremity spasticity seized and developed hypertriglyceridemia, hyperkalemia, and metabolic acidosis. A presumed diagnosis of propofol infusion syndrome (PRIS) was made, but further investigation revealed neonatal adrenoleukodystrophy. PRIS should be considered with this constellation of symptoms, but other neurometabolic disorders must ...
Bogsrud Martin Prøven - - 2013
Objective. The aim of the present study was to evaluate the possible effects of Q10 and selenium supplementation on statin-induced myopathy (SIM), both for subjective symptoms and muscle function. Design. Patients (N = 43) who had experienced previous or ongoing SIM on atorvastatin therapy were recruited. Following a 6-week washout ...
Ahrens Brian D - - 2013
Isotope ratio mass spectrometry (IRMS) testing is performed to determine if an atypical steroid profile is due to administration of an endogenous steroid. Androsterone (Andro) and etiocholanolone (Etio), and/or the androstanediols (5α- and 5β-androstane-3α,17β-diol) are typically analyzed by IRMS to determine the (13) C/(12) C ratio. The ratios of these ...
Wang Xindong - - 2013
A novel strategy was proposed for preparing a highly sensitive glycoprotein sensor based on molecularly imprinted polymers (MIP), which was electropolymerized with o-phenylenediamine and 3-aminophenylboronic acid monohydrate in the presence of template molecules (bovine serum albumin (BSA)). Sensitivity improved dramatically owing to the application of a graphene-Au nanoparticles hybrid as ...
Tsukamoto Megumi - - 2013
Many of the neurodegenerative diseases associated with a decrease in regional cerebral blood flow (rCBF) are untreatable, and the appropriate therapeutic strategy is to slow the progression of the disease. Therefore, it is important that a definitive diagnosis is made as soon as possible when such diseases are suspected. Diagnostic ...
Papp K A - - 2013
BACKGROUND: Long-term safety evaluations of biologics are needed to inform patient management decisions. OBJECTIVES: To evaluate the safety of ustekinumab in patients with moderate-to-severe psoriasis treated for up to five years. PATIENTS AND METHODS: Safety data were pooled from four studies of ustekinumab for psoriasis. Rates of adverse events (AEs), ...
Fischer Jan - - 2013
Extracellular kallikrein-related peptidases (KLKs) are involved in the desquamation process and the initiation of epidermal inflammation by different mechanisms. Their action is tightly controlled by specific protease inhibitors. Recently, we have identified the serine protease inhibitor of Kazal-type (SPINK) 6 as a selective inhibitor of KLKs in human stratum corneum ...
Burden Christy - - 2013
OBJECTIVES: Prospective cohort study to assess the usability of virtual-reality (VR) simulation for obstetric ultrasound trainees. METHODS: Twenty-six participants were recruited; 18 obstetric ultrasound trainees (with little formal ultrasonography training) and eight certified experts. They all performed five sequential VR-simulated crown-rump length (CRL) scans in a single session and three ...
Saito Keiichi - - 2013
Although costimulatory molecules have been shown to play crucial roles in the immune response, their involvement in the pathogenesis of Sjögren's syndrome is incompletely understood. In this study, we evaluated the relationship between the severity of spontaneous Sjögren's syndrome-like autoimmune sialadenitis in MRL/MpJ-lpr/lpr (MRL-Fas(lpr)) mice and the expression of 6 ...
Jones-Webb Rhonda - - 2013
We contacted gay bar/club managers in 16 metropolitan statistical areas (MSAs) in the US from 2008 to 2010 and invited them to participate in survey of gay bar/club identification and patronage. The annual response rates were 58%, 74%, and 71%, respectively. We convened two, 1-hr meetings with research staff to ...
Zhu Tianwei - - 2013
Using density functional theory (DFT) and thermodynamic considerations we studied the equilibrium shape of Pt nanoparticles (NPs) under electrochemical conditions. We found that at very high oxygen coverage, obtained at high electrode potentials, the experimentally-observed tetrahexahedral (THH) NPs consist of high-index (520) faces. Since high-index surfaces often show higher (electro-)chemical ...
KochaƄczyk Tomasz - - 2013
The minimal zinc hook peptide of Rad50 and its alanine mutants form highly stable Zn(ii) complexes. These peptides were successfully used as a small, efficient tag for reversible Zn(ii)-mediated protein homodimerization. The high stability, its biological consequences and potential applications in protein engineering are discussed.
Aeschbacher S - - 2013
We propose a two-step procedure for estimating multiple migration rates in an approximate Bayesian computation (ABC) framework, accounting for global nuisance parameters. The approach is not limited to migration, but generally of interest for inference problems with multiple parameters and a modular structure (e.g. independent sets of demes or loci). ...
Chang Yu-Hsiang - - 2013
Natural killer (NK) cells rely on surface receptors to distinguish healthy cells from cancer cells. We designed a receptor termed NKG2D-DAP10-CD3ζ that is composed of the NK cell activating molecule NKG2D plus two key signaling molecules, DAP10 and CD3ζ, and evaluated its capacity to promote cancer cell killing. Retroviral transduction ...
Jensen Rebekka Vibjerg - - 2013
Objectives. Through the hexosamine biosynthetic pathway (HBP) proteins are modified by O-linked-β-N-acetylglucosamine (O-GlcNAc), which acts as a stress sensor. Augmentation of O-GlcNAc confers cardioprotection against ischemia- reperfusion injury, but its role in ischemic preconditioning (IPC) is unknown. Azaserine and alloxan are unspecific blockers of the HBP and have been used ...
Sattler Sebastian - - 2013
This online panel study (n(t)(1) = 5,882; n(t)(2) = 3,486 (randomly selected)) used multiple metrics to assess the prevalence of the nonmedical use of prescription medication for enhancing cognitive performance among German university students in 2010. Rare events logistic regression revealed that increased cognitive test anxiety increased the prevalence of ...
Lago Paola - - 2013
BACKGROUND: National and international guidelines have been published on pain control and prevention in the newborn, but data on compliance with these guidelines are lacking. AIM: To document current hospital practices for analgesia at neonatal intensive care units (NICUs) 5 years after national guidelines were published in Italy. METHODS: A computer-based ...
Deng Zhipeng - - 2013
Brazilin is a major homoisoflavonoid component isolated from the dried heartwood of traditional Chinese medicine Caesalpinia sappan L., which is a natural red pigment used for histological staining. Herein a sensitive, specific and rapid analytical LC-MS/MS method was established and validated for brazilin in rat plasma. After a simple step ...
Bloomgarden Zachary - - 2013
Various aspects of lifestyle are associated with the development of obesity, including physical activity, cigarette use (and its cessation), alcohol, television watching, computers, and sleep. Dietary factors are particularly important, both those leading to weight gain, such as starches, meats, fats, and sugar-sweetened beverages, and those contributing to weight maintenance ...
Eshah Nidal F - - 2013
Risk factor reduction and modification of patient lifestyle have become the focus of secondary prevention and cardiac rehabilitation programs. Considering the scarcity of resources in developing countries, nurses can potentially provide great benefit to acute coronary syndrome patients by utilizing hospital time to teach the patients how to lower their ...
Rusznák Zoltán - - 2013
Giant cells of the cochlear nucleus are thought to integrate multimodal sensory inputs and participate in monaural sound source localization. Our aim was to explore the significance of a hyperpolarization-activated current in determining the activity of giant neurones in slices prepared from 10 to 14-day-old rats. When subjected to hyperpolarizing ...
Hosseini Seyyed Vahide - - 2013
Parents are likely to be key influences on children's physical activity behaviors, although it is not clear how. This study was designed to explore parents' roles in Iranian adolescent girls' physical activity habit development. A qualitative study was conducted by means of semistructured one-to-one interviews with 25 participants, including 16 ...
Kuper-Hommel Marion J J - - 2013
ABSTRACT Population-based series analyzing clinical implications of nodal versus extranodal presentation of marginal zone lymphoma(MZL) are lacking. We studied clinical differences and trends in incidence, therapy and survival of nodal and extranodal MZL, and of MZL at different extranodal sites, in a population-based cohort. All patients with localized (AAS I&II) ...
Sakly C - - 2013
Reproductive outputs in fat-tailed Barbarine sheep in central Tunisia are often low because of feed shortage and the low nutritive value of diets. Supplementation with conventional concentrates is economically unsuitable in central Tunisia, so more cost-effective and sustainable alternative feeding strategies need to be developed. We tested effects of short-term ...
Vallooran Jijo J - - 2013
We present a new strategy to control the anisotropic diffusion of hydrophilic drugs in lyotropic liquid crystals, via dispersion of magnetic nanoparticles in the mesophase, followed by re-orientation of the mesophase domains via an external magnetic field. We select a lipid reverse hexagonal phase doped with magnetic iron-oxide nanoparticles and ...
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