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Clark Virginia C - - 2013
Telaprevir and boceprevir are the first direct-acting antiviral agents approved for use in HCV treatment and represent a significant advance in HCV therapy. However, these first-generation drugs also have significant limitations related to thrice-daily dosing, clinically challenging side-effect profiles, low barriers to resistance and a lack of pan-genotype activity. A ...
Lim Jun Uk - - 2013
: Recently, it was reported that postmenopausal women with lower bone mineral density have an increased risk of colorectal cancer. An association between lower bone mineral density and colorectal cancer suggests that colorectal adenoma, which is a precursor of colorectal cancer, may also be associated with lower bone mineral density. ...
Chopra Angeli - - 2013
Antiviral therapy for chronic hepatitis C has dramatically changed with the advent of triple therapy incorporating direct-acting antivirals (DAAs) such as the protease inhibitors (PI) boceprevir and telaprevir. Such triple-therapy is associated with a new spectrum of side-effects which can hamper quality of life. These may lead to dosage reduction ...
Bock Susanne - - 2013
Stapled transanal rectal resection with a new, curved, multifire stapler (Transtar procedure) has shown promising short- and midterm results for treating obstructed defecation syndrome. However, few results have been published on long-term outcome. This study aimed to investigate long-term functional results and quality of life after the Transtar procedure. This ...
Carbone Jeanine F - - 2013
To test the hypothesis that use of the Foley bulb plus vaginal misoprostol will result in shorter induction-to-delivery time compared with vaginal misoprostol alone. We randomized 123 women undergoing induction of labor with singleton pregnancies at 24 weeks of gestation or greater with an unfavorable cervix (Bishop score 6 or ...
Shimbo Daichi D Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA. - - 2013
Unhealthy lifestyle factors may contribute to apparent treatment resistant hypertension (aTRH). We examined associations of unhealthy lifestyle factors with aTRH in individuals taking antihypertensive medications from three or more classes. Participants (n = 2602) taking three or more antihypertensive medication classes were identified from the population-based REasons for Geographic And ...
Bello Danielle M DM Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, - - 2013
Anatomic site is a predictive factor in subtypes of cutaneous and mucosal melanoma. The aim of this study was to examine the clinical relevance of location of origin of anorectal melanoma as a prognostic factor. With the use of a prospectively maintained database, clinical characteristics, management, and outcomes were compared ...
Hickey Kathleen T KT School of Nursing, Columbia University, New York, NY, USA. - - 2013
To determine the relationship between quality of life and perceived self-reported symptoms in an older, ambulatory, urban population living with heart failure. While arrhythmias in older individuals with heart failure are well documented, the association between perceived arrhythmia symptoms and quality of life is not well-defined. Prospective, cross-sectional single-centre study. ...
Zhao Ming-Tao MT Division of Animal Sciences, University of Missouri, Columbia, MO 65211, - - 2013
During early mammalian embryogenesis, there is a wave of DNA demethylation postfertilization and de novo methylation around implantation. The paternal genome undergoes active DNA demethylation, whereas the maternal genome is passively demethylated after fertilization in most mammals except for sheep and rabbits. However, the emerging genome-wide DNA methylation landscape has ...
Park In Ja IJ Department of Surgical Oncology, University of Texas, MD Anderson Cancer Center, Houston, Texas 77230-1402, - - 2013
Neoadjuvant chemoradiotherapy before total mesorectal excision for rectal cancer is associated with improved local tumor control, primary tumor regression, and pathologic downstaging. Therefore, tumor response in the bowel wall has been proposed to be used to identify patients for organ-preserving strategies. The aim of this study was to determine the ...
Daugherty Stacie L SL Division of Cardiology, University of Colorado Denver, Aurora, Colorado 80045, USA. - - 2013
The time of initial hypertension diagnosis represents an opportunity to assess subsequent risk of adverse cardiovascular outcomes. The extent to which women and men with newly identified hypertension are at a similar risk for adverse cardiovascular events, including chronic kidney disease (CKD), is not well known. Among women and men ...
Wilde Mary H MH School of Nursing & Center for Community Health, University of Rochester, Rochester, NY 14642, USA. - - 2013
To characterise a sample of 202 adult community-living long-term indwelling urinary catheter users, to describe self-care practices and catheter problems, and to explore relationships among demographics, catheter practices and problems. Long-term urinary catheter users have not been well studied, and persons using the device indefinitely for persistent urinary retention are ...
Carelli Valerio V Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy. - - 2013
We review the recent advances in animal models generated to study the complexities of mitochondrial optic neuropathies and the therapeutic strategies proposed for these disorders. We have recently witnessed a rapid proliferation of animal models attempting to recapitulate the clinical and pathogenic features of human genetic mitochondrial optic neuropathies, that ...
Zama Aparna Mahakali AM Department of Animal Sciences, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, - - 2013
Transient exposure to methoxychlor (MXC), an environmental endocrine-disrupting chemical, during fetal and neonatal stages causes ovarian dysfunction in pubertal, adult, and aging animals. Adult animals have reduced number of ovulations and abnormal follicular composition associated with altered gene expression and DNA methylation patterns. To test the hypothesis that the ovarian ...
Taylor Paul P The National Clinical FES Centre, Salisbury District Hospital, Salisbury, United Kingdom. - - 2013
Functional Electrical Stimulation (FES) for correction of dropped foot has been shown to increase mobility, reduce the incidence of falls and to improve quality of life. This study aimed to determine how long the intervention is of benefit, and the total cost of its provision. Retrospective review of medical records. ...
Hodgkinson James A JA Primary Care Clinical Sciences, University of Birmingham, Edgbaston, Birmingham, UK. - - 2013
Recent research and guidelines recommend the routine use of ambulatory blood pressure monitoring for the diagnosis of hypertension, so accuracy of such monitors is more important than ever. : To systematically review the literature regarding the accuracy of ambulatory monitors currently in use. Medline, Embase, Cinahl, the Cochrane database, Medion ...
Bergek Christian C Section for Anaesthesia, Linköping University, Linköping, - - 2013
Measurement of blood haemoglobin concentration by pulse oximetry could be of value in determining when erythrocytes should be transfused during surgery, but the effect of infusion fluids on the results is unclear. To study the effect of crystalloid and colloid fluid on the accuracy (bias) and precision of pulse oximetry ...
Hagan Liesl M LM Center for AIDS Research, Emory University School of Medicine and Veterans Affairs Medical Center, Decatur, GA 30033, USA. - - 2013
Worldwide eradication of hepatitis C virus (HCV) is possible through a combination of prevention education, universal clinical and targeted community screening, effective linkage to care and treatment with promising new direct-acting antiviral drug regimens. Universal screening should be offered in all healthcare visits, and parallel community screening efforts should prioritize ...
Chávez-Canales María M Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México and Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Mexico City, - - 2013
Insulin is recognized to increase renal salt reabsorption in the distal nephron and hyperinsulinemic states have been shown to be associated with increased expression of the renal NaCl cotransporter (NCC). However, the effect of insulin on NCC functional activity has not been reported. Using a heterologous expression system of Xenopus ...
Li Fei F Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United - - 2013
The application of mass spectrometry-based metabolomics in the field of drug metabolism has yielded important insights not only into the metabolic routes of drugs but has provided unbiased, global perspectives of the endogenous metabolome that can be useful for identifying biomarkers associated with mechanism of action, efficacy, and toxicity. In ...
Patterson Steven E SE Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, Minnesota 55455, USA. - - 2013
Current cyanide antidotes are administered by IV infusion, which is suboptimal for mass casualties. Therefore, in a cyanide disaster, intramuscular (IM) injectable antidotes would be more appropriate. We report the discovery of the highly water-soluble sulfanegen triethanolamine as a promising lead for development as an IM injectable cyanide antidote.
Rudolf Jeffrey D JD Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, United - - 2013
The aromatic prenyltransferase dimethylallyltryptophan synthase in Claviceps purpurea catalyzes the normal prenylation of tryptophan at C4 of the indole nucleus in the first committed step of ergot alkaloid biosynthesis. 4-Methyltryptophan is a competitive inhibitor of the enzyme that has been used in kinetic studies. Upon investigation of background activity during ...
Shao Hao H School of Pharmacy and Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, - - 2013
Cancer cells often have a high demand for antiapoptotic proteins in order to resist programmed cell death. CDK9 inhibition selectively targets survival proteins and reinstates apoptosis in cancer cells. We designed a series of 4-thiazol-2-anilinopyrimidine derivatives with functional groups attached to the C5-position of the pyrimidine or to the C4-thiazol ...
Xu Xinfang X Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, - - 2013
A regiospecific synthesis of multifunctional pyrazoleshas been developed from a cascade process triggered by Rh(II)-catalyzed dinitrogen extrusion from enol diazoacetates with vinylogous nucleophilic addition followed by Lewis acid catalyzed cyclization and aromatization.
Wilson Daniel J DJ Center for Drug Design, University of Minnesota , Minneapolis, MN 55455, United - - 2013
Aureusimines have been identified as potential virulence factors in Staphylococcus aureus. These pyrazinone secondary metabolites are produced by a nonribosomal peptide synthetase (NRPS) annotated as AusA. We report the overproduction of AusA as a 277 kDa soluble protein with A(1)-T(1)-C-A(2)-T(2)-R bimodular architecture. The substrate specificity of each adenylation (A) domain ...
Vugmeyster Liliya L Department of Chemistry, University of Alaska Anchorage, Anchorage, Alaska 99508, USA. - - 2013
We investigated site-specific dynamics of key methyl groups in the hydrophobic core of chicken villin headpiece subdomain (HP36) over the temperature range between 298 and 140 K using deuteron solid-state NMR longitudinal relaxation measurements. The relaxation of the longitudinal magnetization is weakly nonexponential (glassy) at high temperatures and exhibits a ...
Rogers Joseph M JM Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, - - 2013
Coupled folding and binding of intrinsically disordered proteins (IDPs) is prevalent in biology. As the first step toward understanding the mechanism of binding, it is important to know if a reaction is 'diffusion-limited' as, if this speed limit is reached, the association must proceed through an induced fit mechanism. Here, ...
Liu Hongguang H Molecular Imaging Program at Stanford (MIPS), Bio-X Program, Department of Radiology, Stanford University, California, 94305-5344, - - 2013
Melanoma is an aggressive skin cancer with worldwide increasing incidence. Development of positron emission tomography (PET) probes for early detection of melanoma is critical for improving the survival rate of melanoma patients. In this research, (18)F-picolinamide-based PET probes were prepared by direct radiofluorination of the bromopicolinamide precursors using no-carrier-added (18)F-fluoride. ...
Hahne Hannes H Chair for Proteomics and Bioanalytics, Center of Life and Food Sciences, Weihenstephan, Technische Universität München, Freising, - - 2013
The post-translational modification of proteins with N-acetylglucosamine (O-GlcNAc) is involved in the regulation of a wide variety of cellular processes and associated with a number of chronic diseases. Despite its emerging biological significance, the systematic identification of O-GlcNAc proteins is still challenging. In the present study, we demonstrate a significantly ...
Li Qiao - - 2013
Currently, flow cytometry and immunomagnetic bead purification are the most commonly used cell sorting methods. We performed this study because there are few reports that directly compare the sorting efficiency and influence on cell functions of these two methods. The in vitro cultured third-generation bone marrow mesenchymal cells from newborn ...
Simon Claudia - - 2013
VP1, the major coat protein of polyomavirus, assembles intracellularly to virus-like particles if expressed in eukaryotes. Here, the nonconventional yeast Kluyveromyces lactis was used for production of virus-like particles of murine polyomavirus. The heterologous gene of VP1 was integrated in the LAC4 locus of the GAL/LAC genes. Consequently the expression ...
Mall Ruckminee - - 2013
A soluble and thermostable peroxidase enzyme (POD) was extracted from the leaf of Citrus medica. The enzyme was purified 15.10-fold with a total yield of 28.6% by ammonium sulfate precipitation followed by Sephadex G-100 gel filtration chromatography. The purified enzyme came as a single band on native polyacrylamide gel electrophoresis ...
Zhang Yuliang - - 2013
[BPy]H(2)PO(4) was easily prepared and used as an efficient and recyclable catalyst for the one-pot synthesis of 2,4,5-trisubstituted imidazoles under solvent-free conditions in good to excellent yields. Solvent-free conditions, simple experimental and workup procedures, and the use of a nontoxic, recyclable catalyst of an environmentally benign nature are remarkable features ...
Karn Santosh Kr - - 2013
Hydrolytic enzymes released by the microorganisms in activated sludge are responsible for the organic matter degradation there; however, the optimal extraction procedure of this valuable resource has not been well established until now. In this study protease and lipase were extracted from activated sludge using ultrasound disintegration combined with a ...
Li Dengchao - - 2013
This study developed a simple, efficient method for producing racemic β-phenylalanine acid (BPA) and its derivatives via the enantioselective acylation catalyzed by the penicillin G acylase from Alcaligenes faecalis (Af-PGA). When the reaction was run at 25°C and pH 10 in an aqueous medium containing phenylacetamide and BPA in a ...
Taskin Mesut - - 2013
The aim of this study is to investigate the effect of low-intensity static magnetic fields (SMFs) on invertase activity and growth on different newly identified molds. The most positive effect of SMFs on invertase activity and growth was observed for Aspergillus niger OZ-3. The submerged production of invertase was performed ...
Sanlier Senay Hamarat - - 2013
One of the most important classes of pollutants is dyes, and today there are more than 100,000 commercial dyes. Conventional treatment processes are very expensive, so it is essential to develop low-cost sorbent materials with high adsorption capacities. The aim of this study is to prepare magnetic microsized adsorbents that ...
- - 2013
On August 13, 2012, a nephrologist reported to the Tennessee Department of Health (TDH) three cases of unexplained thrombotic thrombocytopenic purpura (TTP), a rare but serious blood disorder characterized by microangiopathic hemolytic anemia and thrombocytopenia. The annual incidence is approximately 1 per 100,000 population. Known risk factors for TTP include ...
- - 2013
Artesunate has been recommended by the World Health Organization (WHO) as the first-line treatment for severe malaria since 2010. It is not licensed in the United States but is available from CDC under an investigational new drug (IND) protocol. During 2010-2012, a total of 19 cases of delayed hemolytic anemia ...
- - 2013
Excessive alcohol use accounted for an estimated average of 23,000 deaths and 633,000 years of potential life lost (YPLL) among women and girls in the United States each year during 2001-2005. Binge drinking accounted for more than half of those deaths and YPLL. Binge drinking also is a risk factor ...
Le Bourgeois Amandine - - 2013
This retrospective analysis aimed to assess hematopoietic and immune recovery in a cohort of 53 patients (males: n=33; median age: 59 years (range: 22-70)) who received a FB2 (fludarabine 120-150 mg/m² + IV busulfan 6.4 mg/Kg + ATG thymoglobuline 5mg/Kg) reduced-intensity conditioning (RIC) allo-SCT. With a median follow-up of 19 ...
Nurita A T - - 2013
Two types of municipal solid waste (MSW), newly arrived and 2 weeks old, were sampled from a sanitary landfill in Pulau Pinang, Malaysia at a fortnightly interval and kept under field conditions for 2 weeks. A total of 480 kg of each type of MSW was sampled to study species ...
Frecus Bogdan - - 2013
Encapsulation of spin-labels into "host" compounds, like cucurbit[n]urils or cyclodextrins, in solutions has profound effects on the EPR spin Hamiltonian parameters of the spin-labels. In this work we study the microscopic origin of the EPR spin Hamiltonian parameters of spin-labels enclosed in hydrophobic cavities. We focus on the dependence of ...
Khan Shujaul M - - 2013
ABSTRACT: Mountain ecosystems all over the world support a high biological diversity and provide home and services to some 12% of the global human population, who use their traditional ecological knowledge to utilise local natural resources. The Himalayas are the world's youngest, highest and largest mountain range and support a ...
Muncaci Sergiu - - 2013
Frequency-dependent NMR relaxation studies have been carried out on water (polar) and cyclohexane (nonpolar) molecules confined inside porous ceramics containing variable amounts of iron oxide (III). The porous ceramics were prepared by compression of powders mixed with iron oxide followed by thermal treatment. The pore size distribution was estimated using ...
Khimji Imran - - 2013
The melting temperature of duplex DNA is much higher in polyanions than in non-ionic polymers with similar ionic strength, suggesting an additional electrostatic contribution on top of the excluded volume effect.
Bere T - - 2013
We have limited insight into how injuries occur in professional ski racing. The aim of this study was to describe the injury situations in World Cup alpine skiing. Injuries reported through the International Ski Federation Injury Surveillance System for three consecutive World Cup seasons (2006-2009) were obtained on video. In ...
Liang B - - 2013
Gastroesophageal reflux disease (GERD) may be a potential risk factor for exacerbations of chronic obstructive pulmonary disease (COPD). The aim of the present study was to explore the association of GERD risk with exacerbations of COPD. Patients with COPD were consecutively recruited, and COPD Assessment Test (CAT) and Reflux Diagnostic ...
Antonenko Daria - - 2013
As well as consolidating memory, sleep has been proposed to serve a second important function for memory, i.e. to free capacities for the learning of new information during succeeding wakefulness. The slow wave activity (SWA) that is a hallmark of slow wave sleep could be involved in both functions. Here, ...
Dani Prateek - - 2013
Abstract Objective: This study aimed to evaluate kinetic solubility advantage of amorphous etoricoxib solid dispersions prepared with three water soluble polymers and correlate it with solid state and supersaturated drug solution stabilization potential of these polymers. Methods: Amorphous solid dispersions (ASDs) of etoricoxib were prepared with polyvinyl alcohol (PVA), polyvinyl ...
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