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Yu Rongqin - - 2013
OBJECTIVE: We examined the potential moderating role of Block's personality types (i.e., overcontrollers, undercontrollers, and resilients) on the longitudinal associations between adolescents' and their best friends' delinquency. METHOD: Across three annual waves, 497 Dutch adolescents (283 boys, M(Age) = 13 years at Wave 1) and their best friends reported on ...
Gu Ben J - - 2013
Age-related macular degeneration (AMD) is a leading cause of blindness in Western countries and is diagnosed by the clinical appearance of yellow subretinal deposits called drusen. Genetic changes in immune components are clearly implicated in the pathology of this disease. We have previously shown that the purinergic receptor P2X7 can ...
Tabouret Emeline - - 2013
Recent progresses in chemotherapies and targeted therapies have improved survival in cancer patients. In this context of better-controlled systemic disease, brain metastases (BM) are emerging as a new challenge for the oncologist. However, BM epidemiology and biology remain largely unclear. Incidence of BM is increasing. This trend could be explained ...
Qiu Shuwei - - 2013
ABSTRACT: BACKGROUND: Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor with poor clinical outcome. Identification and development of new markers could be beneficial for the diagnosis and prognosis of GBM patients. Deregulation of microRNAs (miRNAs or miRs) is involved in GBM. Therefore, we attempted to identify and ...
Minard-Colin Véronique - - 2013
BACKGROUND: To evaluate a strategy whereby extensive surgery ± external radiotherapy (RT) could improve local control in pterygopalatine/infratemporal fossa (PIF) sarcoma. PROCEDURE: Forty-one patients with a diagnosis of sarcoma involving the PIF and referred to our Institute from 1984 to 2009 were included in the analysis. Patients received multidrug chemotherapy and radiotherapy ± surgery, ...
Giang Kok Wai - - 2013
AimsThe aim of this study was to examine the short-term and long-term cumulative risk of coronary heart disease (CHD) and stroke separately based on age, sex, smoking status, systolic blood pressure, and total serum cholesterol.Methods and resultsThe Primary Prevention Study comprising 7174 men aged between 47 and 55 free from ...
Chen Zhaowei - - 2013
In this paper, we present a facile strategy to synthesize hyaluronic acid (HA) conjugated mesoporous silica nanoparticles (MSP) for targeted enzyme responsive drug delivery, in which the anchored HA polysaccharides not only act as capping agents but also as targeting ligands without the need of additional modification. The nanoconjugates possess ...
Bunker Brittany - - 2013
Abstract Populations of several species of gregarine parasites within a single host species, the damselfly Ischnura verticalis, were examined over the course of 1 season at 4 geographic localities separated by a maximum distance of 9.7 km. Gregarines, having a life cycle with both exogenous and endogenous stages, are subject ...
León Thierry - - 2013
A novel Ni-catalyzed carboxylation of benzyl halides with CO2 has been developed. The described carboxylation reaction proceeds under mild conditions (atmospheric CO2 pressure) at room temperature. Unlike other routes for similar means, our method does not require well-defined and sensitive organometallic reagents, thus becoming a user-friendly and operationally simple protocol ...
Redina Olga E - - 2013
The genetic basis of the stress-sensitive arterial hypertension was investigated using the quantitative trait loci (QTL) approach. Two groups of F(2) (inherited stress-induced arterial hypertension [ISIAH] × Wistar albino Glaxo [WAG]) hybrid males of different age (3-4 months old and 6 months old) were tested for blood pressure at rest ...
Chen Mo - - 2013
Saccadic eye movements are central to primate behavior and serve to move the eyes to visual objects of interest. Express saccades, unlike regular saccades, occur with very short reaction times, a behavior necessary for speeded reactions in goal-directed behavior. Previous studies have shown that introduction of a blank interval (gap) ...
Vulevic Jelena - - 2013
Metabolic syndrome is a set of disorders that increases the risk of developing cardiovascular disease. The gut microbiota is altered toward a less beneficial composition in overweight adults and this change can be accompanied by inflammation. Prebiotics such as galactooligosaccharides can positively modify the gut microbiota and immune system; some ...
Jou Chuanchau J - - 2013
Rationale: Genetic testing for Long QT Syndrome (LQTS) is now a standard and integral component of clinical cardiology. A major obstacle to the interpretation of genetic findings is the lack of robust functional assays to determine the pathogenicity of identified gene variants in a high throughput manner. Objective: The goal ...
Layek Buddhadev - - 2013
In order to develop a safe, effective, and biocompatible gene delivery vector, a series of hydrophobic amino acid grafted chitosan (AGC) derivatives were synthesized by carbodiimide mediated coupling reaction. Chemical characterization of AGC polymers was performed by NMR and elemental analysis. AGC polymers demonstrated excellent blood compatibility and cell viability ...
Cohen Steven P - - 2013
BACKGROUND:Chronic postsurgical pain (CPSP) affects between 5% and 70% of surgical patients, depending on the surgery. There is no reliable treatment for CPSP, which has led to an increased emphasis on prevention. In this study, we sought to determine whether preventive etanercept can decrease the magnitude of postoperative pain and ...
Legrady Peter - - 2013
Peripheral sensory function and cardiac autonomic neuropathy were studied in 18 nondiabetic and 10 type-2 diabetic hypertensives compared with 11 healthy controls. All the patients were treated with antihypertensive drugs. Cardiac autonomic neuropathy using Ewing method was detected in all patient groups. The current perception threshold values on peroneal nerve ...
Zhuang Peng-Wei - - 2013
BACKGROUND: Recent studies revealed that baicalin, a flavonoid compound derived from the root of Scutellaria baicalensis Georgi, could promote neuron differentiation of NSPCs after commencing the differentiation process in vitro. However, this may not be the most efficacious strategy to determinate cell fate. Here, we have investigated whether baicalin can ...
Hussain Zahid - - 2013
The aim of this study to administer hydrocortisone (HC) percutaneously in the form of polymeric nanoparticles (NPs) to alleviate its transcutaneous absorption, and to derive additional wound-healing benefits of chitosan. HC-loaded NPs had varied particle sizes, zeta potentials, and entrapment efficiencies, when drug-to-polymer mass ratios increased from 1:1 to 1:8. ...
Sanchez Melisa Celeste - - 2013
The mammalian sperm nucleus contains an unusually condensed chromatin, due to replacement of the majority of histones by protamines. However, soon after the spermatozoon penetrates the ooplasm at fertilization, decondensation of this densely packed chromatin must occur to allow formation of the male pronucleus and syngamy. Decondensation is accomplished by ...
Valladares Ricardo - - 2013
In our previous work, we found that feeding Lactobacillus johnsonii to BioBreeding diabetes-prone (BBDP) rats decreased the incidence of diabetes development. The aim of this study was to investigate host pathways affected by L. johnsonii, with specific focus on the rate-limiting enzyme of tryptophan catabolism, indoleamine 2,3-dioxygenase (IDO). Suspensions of ...
Pan Xiaohong - - 2013
Here we reported the antibacterial effect and related mechanism of three nano-Mg(OH)2 slurries using Escherichia coli as model bacteria. X-ray diffraction (XRD), scanning electron microscopy (SEM) and laser particle size analysis revealed that the as-synthesized Mg(OH)2_MgCl2, Mg(OH)2_MgSO4 and Mg(OH)2_MgO are all composed by nanoflakes with different sizes, and their aggregates ...
Balandier Jean-Yves - - 2013
Synthesis, isolation, and characterization of isomerically pure syn- and anti-anthradiindole (ADI) derivatives are described. The anti- and syn-ADI structures are demonstrated by (13)C NMR spectroscopy and by single-crystal X-ray diffraction. The spectroscopic and electrochemical properties as well as the stability of these newly synthesized π-conjugated systems are evaluated and supported ...
Gearry Richard B - - 2013
BACKGROUND: Intestinal failure (IF) is a rare but devastating complication of Crohn's disease. The clinical and surgical factors that predispose to intestinal failure are poorly understood. We aimed to define clinical factors that predispose to intestinal failure. METHODS: A retrospective case-control study was performed using consecutive Crohn's disease (CD) patients ...
Koudelakova Tana - - 2013
Mutations targeting as few as four residues lining the access tunnel extended the half-life of an enzyme in 40 % dimethyl sulfoxide from minutes to weeks and increased its melting temperature by 190 °C. Protein crystallography and molecular dynamics revealed that the tunnel residue packing is a key determinant of protein stability ...
Hu Songliu - - 2013
BACKGROUND: Nasopharyngeal carcinoma (NPC) is a rare malignancy in children and adolescents, and the optimal treatment modality in youths has not been established. The aim of this study was to evaluate the long-term treatment outcomes and complications associated with childhood and adolescent NPC. PROCEDURE: From January 1985 to December 2004, ...
Renesme L - - 2013
AIM: To determine risk factors for accidental out-of-hospital deliveries (OHD), which represent 0.5% of living births in France and are associated with poor neonatal outcomes. METHODS: This retrospective case-control study assessed accidental OHDs that occurred in the Finistère district (Brittany, France) between January 2007 and December 2009. For each OHD ...
Cheng Angela - - 2013
Vulvar defects following tumor extirpation are most commonly closed primarily by the gynecologist but larger and/or radiated defects often require reconstruction with flaps for adequate coverage and wound healing. Recurrence of vulvar carcinomas remains a challenge, so secondary reconstruction becomes increasingly problematic where locoregional flaps (i.e., gracilis, rectus, anterolateral thigh, ...
Demirkaya Metin - - 2013
The objective of this study was to compare the effectiveness of piperacillin-tazobactam (PIP/TAZO) plus amikacin (AMK) (PIP/TAZO+AMK) versus cefoperazone-sulbactam (CS) plus AMK (CS+AMK) for the treatment of febrile neutropenia (FN) in children with cancer. The study was designed prospectively and randomized in 0- to 18-year-old children with lymphoma or solid ...
Baraduc Pierre - - 2013
Recent research on Parkinson's disease (PD) has emphasized that parkinsonian movement, although bradykinetic, shares many attributes with healthy behavior. This observation led to the suggestion that bradykinesia in PD could be due to a reduction in motor motivation. This hypothesis can be tested in the framework of optimal control theory, ...
Zhao Peng - - 2013
An intramolecular pyrone Diels-Alder reaction-elimination retro-Diels-Alder cascade of a vinyl sulfone was used in the synthesis of cavicularin, a molecule possessing conformational chirality. The vinyl sulfone substitution pattern allowed for regiocontrol in the Diels-Alder cascade event.
Mokhtar Galila M - - 2013
Background: The improvement of quality and duration of life of transfusion-dependent B thalassemia patients over the last years discloses several complications due to the underling disorder, iron overload and the treatment with iron chelators. Our Aim was to assess the morbidity patterns and mortality rate of transfusion-dependent thalassemia patients, and ...
Pedersen Stine F - - 2013
Over the last 15 years it has become increasingly clear that dysregulated expression, splicing, and/or functioning of ion channels and transporters (ICTs) occur in all cancers. Being linked to the widely accepted hallmarks of cancer, ICTs represent novel therapeutic, diagnostic and prognostic targets. To discuss the current status of the ...
Ohba Tomonori - - 2013
Water plays an important role in controlling chemical reactions and bioactivities. For example, water transportation through water channels in a biomembrane is a key factor in bioactivities. However, molecular-level mechanisms of water transportation are as yet unknown. Here, we investigate water transportation through narrow and wide one-dimensional (1D) channels on ...
Dhanraj Santhosh - - 2013
BACKGROUND: Shwachman-Diamond syndrome (SDS) is characterized by hypoplasia of the bone marrow and exocrine pancreas and a high risk of leukemia. It is unknown whether solid tumors are part of the disease phenotype. PROCEDURE: We performed copy number alterations using Affymetrix human SNP 6.0 array. Furthermore, we did direct sequencing ...
McNeil Rebecca B - - 2013
ABSTRACT: Over the past two decades, 12 large epidemiologic studies and 2 registries have focused on U.S. veterans of the 1990--1991 Gulf War Era. We conducted a review of these studies' research tools to identify existing gaps and overlaps of efforts to date, and to advance development of the next ...
Xu Lei - - 2013
While chondrogenesis of mesenchymal stem cells (MSCs) in vitro has been extensively studied, their participation in cartilage tissue repair remains unresolved. This study was designed to elucidate if MSCs affect the phenotype of articular chondrocytes (ACs). A combination of non-contact coculture modes were developed. Human or rabbit MSCs (hMSCs or ...
de Weerd Louis - - 2013
Extensive and complex defects after neurosurgical oncologic resections including dura are a challenge, as watertight closure is of paramount importance. This article illustrates the usefulness of a free myoperitoneal flap in closure of such a defect when located at the skull base or cranium. The vascularized peritoneum appears to be ...
Wu Qi - - 2013
ABSTRACT: Candida antarctica lipase B (CALB) is a robust and easily expressed enzyme used widely in academic and industrial laboratories with many different kinds of applications. In fine chemicals production, examples include acylating kinetic resolution of racemic secondary alcohols and amines as well as desymmetrization of prochiral diols (or the ...
Astori Simone - - 2013
The T-type Ca(2+) channels encoded by the Ca(V)3 genes are well established electrogenic drivers for burst discharge. Here, using Ca(V)3.3(-/-) mice we found that Ca(V)3.3 channels trigger synaptic plasticity in reticular thalamic neurons. Burst discharge via Ca(V)3.3 channels induced long-term potentiation at thalamoreticular inputs when coactivated with GluN2B-containing NMDA receptors, ...
Munuganti Ravi Sashi Nayana - - 2013
The human androgen receptor (AR) is a proven therapeutic target in prostate cancer. All current anti-androgens, such as Bicalutamide, Flutamide, Nilutamide and Enzalutamide, target the buried hydrophobic androgen binding pocket of this protein. However, effective resistance mechanisms against these therapeutics exist, such as mutations occurring at the target site. To ...
van Genderen Michel E - - 2013
BACKGROUND:In healthy volunteers, we investigated the ability of the pulse oximeter-derived peripheral perfusion index (PPI) to detect progressive reductions in central blood volume.METHODS:Twenty-five awake, spontaneously breathing, healthy male volunteers were subjected to progressive reductions in central blood volume by inducing stepwise lower body negative pressure (LBNP) with 20 mm Hg ...
Perinetti Giuseppe - - 2013
Abstract Objective: To evaluate the timing of spontaneous maxillary canine eruption in relation to stages of mandibular second molar maturation. Potential confounding effects from such factors as age, growth phase, and facial features were also explored. Subjects and Methods: A sample of 106 healthy subjects (48 females and 58 males; ...
Tay William Maung - - 2013
The accumulation of plagues of β-amyloid (Aβ) peptides in the brain is a hallmark of Alzheimer's disease (AD). The redox-active Cu and Fe complexes of Aβ can cause damage to the neurons potentially via reactive oxygen species (ROS). The significant metal-mediated oxidative activity of CuAβ suggests that its presence can ...
Lee Chiew Leng - - 2013
We report a rare case of a gastric duplication cyst in the tail of the pancreas in a child presenting with chronic abdominal pain which was cured by excision of the cyst and adjacent pancreas. This case report highlights the role of sonography as an excellent imaging tool for depiction ...
Kwon Ha-Jeong - - 2013
Yam saponins (dioscin, gracillin, protodioscin, and protogracillin) were analyzed with three different C18 columns at incremental column temperatures from 15 to 45°C to investigate the effect of temperature on the retention and resolution of yam saponins. At low temperature, yam saponins showed decreased retention times and improved resolutions in the ...
Seo Woo Duck - - 2013
AMPK is an intracellular sensor that modulates the energy balance within the cell. AMPK was activated significantly by the hexane extract of barley sprouts. This AMPK activation emerges across the growth stages of the sprout, becoming most significant (three times above the initial stages) 10 days after seeding. After this ...
Aoki Atsushi - - 2013
ABSTRACT: BACKGROUND: Osteoprotegerin is a member of the tumor necrosis factor-related family and inhibits RANK stimulation of osteoclast formation as a soluble decoy receptor. The goal of this study was to determine the relationship of serum osteoprotegerin with vascular calcification in patients with type 2 diabetes. METHODS: The subjects were ...
Friedman Scott L - - 2013
Fibrosis, or the accumulation of extracellular matrix molecules that make up scar tissue, is a common feature of chronic tissue injury. Pulmonary fibrosis, renal fibrosis, and hepatic cirrhosis are among the more common fibrotic diseases, which in aggregate represent a huge unmet clinical need. New appreciation of the common features ...
Li Xiao-Fang - - 2013
The low-temperature flowering-response pathway, used as inductive stimuli to induce flowering in plant species from temperate regions in response to cold temperature, has been extensively studied. However, limited information is available on the flower transition of several bulbous species, which require high temperature for flower differentiation. Narcissus tazetta var. chinensis ...
Jacobson Tara Kennedy - - 2013
Hippocampal theta and gamma oscillations coordinate the timing of multiple inputs to hippocampal neurons and have been linked to information processing and the dynamics of encoding and retrieval. One major influence to hippocampal rhythmicity is from cholinergic afferents. In both humans and rodents, aging is linked to impairments in hippocampus ...
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