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Prinsen C A C - - 2013
In the last decade, the importance of the measurement of health-related quality of life (HRQoL) has grown significantly. Today, HRQoL measurement is generally considered to be important in clinical trials, in the assessment of disease severity, in patient management and in the field of health economics. Therefore, a good understanding ...
van Rijt Willem G - - 2013
ABSTRACT: BACKGROUND: In contrast with various pre-clinical studies, recent clinical trials suggest that high dose erythropoietin (EPO) treatment following kidney transplantation does not improve short-term outcome and that it even increases the risk of thrombotic events. ARA290 is a non-erythropoietic EPO derivative and does not increase the risk of cardiovascular ...
Hamedani Maryam G - - 2013
Today's most pressing social challenges require people to recognize their shared fate and work together-to think and act interdependently. In the three studies reported here, we found that appeals for increased interdependence may undermine the very motivation they seek to inspire. We examined the hypothesis that invoking interdependent action undermines ...
Lockwood Thomas D - - 2013
In the 1930's pioneers discovered that maximal autolysis in tissue homogenates requires metal chelator, sulfhydryl reducing agent and acid pH. However, metals, reducing equivalents and protons (MR&P) have been overlooked as combined catalytic controls. Three categories of lysosomal machinery drive three distinguishable cycles importing and exporting MR&P. Zn(2+) preemptively inhibits ...
Rudashevskaya Elena L - - 2013
The identification and validation of crosslinked peptides by mass spectrometry remains a daunting challenge for protein-protein crosslinking approaches when investigating protein interactions. This includes the fragmentation of crosslinked peptides in the mass spectrometer <i>per se</sup> and following database searching, the matching of the molecular masses of the fragment ions to ...
Balaburski Gregor M - - 2013
The stress-induced heat shock protein 70 (HSP70) is an ATP-dependent molecular chaperone that plays a key role in refolding misfolded proteins and promoting cell survival following stress. HSP70 is marginally expressed in non-transformed cells, but is greatly overexpressed in tumor cells. Silencing HSP70 is uniformly cytotoxic to tumor but not ...
Agarwala Hemlata - - 2013
The diamagnetic complexes [Ru(tpm)(bqdi)(Cl)]ClO(4) ([]ClO(4)) (tpm = tris(1-pyrazolyl)methane, bqdi = o-benzoquinonediimine) and [Ru(tpm)(bqdi)(H(2)O)](ClO(4))(2) ([](ClO(4))(2)) have been synthesized. The valence state-sensitive bond distances of coordinated bqdi [C-N: 1.311(5)/1.322(5) Å in []ClO(4); 1.316(7)/1.314(7) Å in molecule and 1.315(6)/1.299(7) Å in molecule of [](ClO(4))(2)] imply its fully oxidised quinonediimine (bqdi(0)) character. DFT calculations ...
Molfino Alessio - - 2013
Increased oxidative stress may contribute to cancer anorexia, which could be ameliorated by antioxidant supplementation. methylcholanthrene (MCA) sarcoma-bearing Fisher rats were studied. After tumour inoculation, rats were randomly assigned to standard diet (CTR group, n = 6), or to an antioxidant-enriched diet (AOX group, n = 8). Eight more rats (STD-AOX group) switched from ...
Predicala Rey - - 2013
Influenza A virus vRNP nuclear export is CRM1-dependent. Ran-binding protein 3 (BanBP3) is a Ran-interacting protein that is best known for its role as a cofactor of CRM1-mediated cargo nuclear export. In this study, we investigated the role of RanBP3 during influenza A virus life cycle. We found that RanBP3 ...
Stricker Paul A - - 2013
BACKGROUND:Massive hemorrhage during craniofacial surgery is common and often results in hypovolemia and hypotension. We conducted this study to assess the effect of the addition of routine central venous pressure (CVP) monitoring on the incidence of intraoperative hypotension and to evaluate the relationship between CVP and hypotension in this population.METHODS:Data ...
Davidovic Sonja - - 2013
Physicochemical, sensory and health related characteristics of peach wine produced from Redhaven variety and selected white wines produced from various grape varieties were determined and compared. The alcohol content, titratable acidity and total extract of peach wine was significantly lower compared with white wines, while its pH value was higher. ...
Yang Xuan - - 2013
Basic evidence is provided for the benefits of using cytosine-rich DNA strands as scaffolds for fluorescent silver nanoclusters. The DFT-calculated fluorescence spectra of silver nanoclusters (AgNCs) protected by DNA monomers (dC, dA, dT, and dG) were in good agreement with the experimentally obtained spectra, showing that only the use of ...
Wang Jihong - - 2013
This study investigated the effects of hearing status and age of signed language acquisition on signed language working memory capacity. Professional Auslan (Australian sign language)/English interpreters (hearing native signers and hearing nonnative signers) and deaf Auslan signers (deaf native signers and deaf nonnative signers) completed an Auslan working memory (WM) ...
Fabritz Sebastian - - 2013
Small, compact, and highly symmetric cube-octameric silsesquioxanes have recently attracted increased attention as scaffolds for tailor-made bioconjugates. The expanded arsenal of effective conjugation methods (CuAAC, TEC, oxime ligation) allows one to decorate these nanoparticles bearing up to eight addressable organic substituents, with a wide range of biorelevant ligands, among them ...
Ségaud Nathalie - - 2013
We report the synthesis, characterization, and solution chemistry of a series of new Fe(II) complexes based on the tetradentate ligand N-methyl-N,N'-bis(2-pyridyl-methyl)-1,2-diaminoethane or the pentadentate ones N,N',N'-tris(2-pyridyl-methyl)-1,2-diaminoethane and N,N',N'-tris(2-pyridyl-methyl)-1,3-diaminopropane, modified by propynyl or methoxyphenyltriazolyl groups on the amino functions. Six of these complexes are characterized by X-ray crystallography. In particular, two ...
Torner Núria - - 2013
Measles cases in the European Region have been increasing in the last decade; this illustrates the challenge of what we are now encountering in the form of pediatric preventable diseases. In Catalonia, autochthonous measles was declared eliminated in the year 2000 as the result of high measles-mumps-rubella vaccine (MMR) coverage ...
Meola Juliana - - 2013
Considerable efforts have been invested in elucidating the potential mechanisms involved in the physiopathology of endometriosis. The aims of our study were to investigate whether RHOC expression is differentially altered in the endometrium and in endometriotic lesions. A total of 40 patients diagnosed with endometriosis and 15 healthy fertile women ...
Malonzo C - - 2013
Nucleus pulposus (NP) regeneration by the application of injectable cell-embedded hydrogels is an appealing approach for tissue engineering. We investigated a thermo-reversible hydrogel (TR-HG), based on a modified polysaccharide with a thermo-reversible polyamide [poly(N-isopropylacrylamide), pNIPAM], which is made to behave as a liquid at room temperature and hardens at > 32 °C. In ...
Clark Scott - - 2013
MOTIVATION: Researchers need general-purpose methods for objectively evaluating the accuracy of single and metagenome assemblies, and for automatically detecting any errors they may contain. Current methods do not fully meet this need because they require a reference, only consider one of the many aspects of assembly quality, or lack statistical ...
Badano Luigi P - - 2013
Functional tricuspid regurgitation (FTR) is characterized by structurally normal leaflets and is due to the deformation of the valvulo-ventricular complex. While mild FTR is frequent and usually benign, patients with severe FTR may develop progressive ventricular dysfunction and incur increased mortality. Therefore, FTR should not be ignored, should be appropriately ...
Jin Xi-Feng - - 2013
AIMS: To evaluate the clinical value of multiband mucosectomy for the treatment of squamous intraepithelial neoplasia of the esophagus. METHODS: A total of 51 lesions located at esophagus from 43 patients, were treated with MBM, among which 11 were diagnosed as middle-grade intraepithelial neoplasia (MGIN) and 25 as high-grade intraepithelial ...
Bay Ali - - 2013
Background and objective: To determine the prevalence and the clinical significance of thyroid autoantibodies and their influence on treatment response in children with idiopathic thrombocytopenic purpura (ITP). Patient and Method: We retrospectively analyzed the antithyroglobulin (anti-TG) and antithyroid peroxidase (anti-TPO) antibodies from the records of 151 ITP patients who were ...
Fricke Julia - - 2013
Natural rubber is a high-molecular-mass biopolymer found in the latex of more than 2500 plant species, including Hevea brasiliensis, Parthenium argentatum and Taraxacum spp. The active sites of rubber biosynthesis are rubber particles, which comprise a hydrophobic rubber core surrounded by a phospholipid monolayer membrane containing species-dependent lipids and associated ...
Lechapt-Zalcman Emmanuèle - - 2013
Diagnosis of brain metastases should aim to identify anatomoclinical entities for which a specific treatment is more accurate. Growing numbers of targeted therapies have shown to be effective against specific cancers. Several studies have reported that targeted therapies are capable of reducing brain metastases in melanoma or non small cell ...
Kar Chirantan - - 2013
We have synthesized a new indole functionalized rhodamine derivative L(1) which specifically binds to Cu(2+) in the presence of large excess of other competing ions with visually observable changes in their electronic and fluorescence spectral behavior. These spectral changes are significant enough in the NIR and visible region of the ...
Gill Katherine L - - 2013
A physiologically-based pharmacokinetic (PBPK) modeling approach was used to assess the prediction accuracy of propofol hepatic and extrahepatic metabolic clearance and address previously reported under-prediction of in vivo clearance based on static in vitro-in vivo extrapolation methods. The predictive capacity of propofol intrinsic clearance data (CL(int)) obtained in human hepatocytes, ...
Xue Xiaoying - - 2013
PEGylation can improve the protein efficacy by prolonging serum half-life and reducing proteolytic sensitivity and immunogenicity. However, PEGylation may decrease the bioactivity of a protein by interfering with binding of its substrate or receptors. Here, staphylokinase (SAK), a thrombolysis agent for therapy of myocardial infarction, was mono-PEGylated at the C-terminus ...
McKeever Caitriona - - 2013
Considering the strong DNA minor-groove binding observed for our previous series of di-aromatic symmetric and asymmetric guanidinium and 2-aminoimidazolinium derivatives, we report now the synthesis of new aminoalkyl derivatives of di-aromatic guanidines with potential as DNA minor groove binders and antiprotozoal activity. The preparation of these aminoalkyl derivatives (12a-e; 13a-e; ...
Min Yan - - 2013
Autophagy has been shown to enhance the efficacy of the Bacillus Calmette-Guérin (BCG) vaccine by increasing the peptide presentation of dendritic cells (DCs). Earle's balanced salts solution (EBSS) is a saline solution with physiological pH which is often used to induce autophagy, while rapamycin is a pharmacological reagent used for ...
Tcherkez Guillaume Gb - - 2013
D-Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) is the most abundant enzyme on Earth and is responsible for the fixation of atmospheric CO2 into biomass. The reaction consists of CO2 and solvent H2O incorporation into D-ribulose-1,5-bisphosphate (RuBP) to yield 3-phospho-D-glycerate. The reaction involves several proton-dependent events: abstraction and protonation during enolization of RuBP and ...
Xu Fei - - 2013
Streptonigrin (STN, 1) is a highly functionalized aminoquinone alkaloid with broad and potent antitumor activity. Here, we reported the biosynthetic gene cluster of STN identified by genome scanning of a STN producer Streptomyces flocculus CGMCC4.1223. This cluster consists of 48 genes determined by a series of gene inactivations. Based on ...
Crespo Inma Crespo - - 2013
Pertussis is a vaccine-preventable disease that generates a large number of cases and hospitalizations. In Catalonia, the vaccination schedule includes three doses of vaccine at 2, 4 and 6 mo and two booster doses at 18 mo and 4-6 y. In 2002, DTPw was replaced by DTPa. The aim of ...
Stolte M - - 2013
The Churg-Strauss syndrome (CSS), first described in 1951 and characterised by eosinophilic inflammation and necrotising vasculitis in patients with asthma can in principle affect any organ. We report on a 47-year-old male patient, in whom the diagnosis of CSS was finally established for the first time on the basis of ...
Zhao Lili - - 2013
Aspirin is widely used in the treatment of a number of clinical conditions. Although aspirin is being thought to be a relatively "safe" medicine, it also has some side effects, particularly the risk of bleeding which may be severe and lead to death. The mechanisms, however, are not totally understood. ...
Sidhu Roger - - 2013
Pooled analyses of chemotherapy trials in metastatic colorectal cancer (mCRC) have suggested that progression-free survival (PFS) is a surrogate endpoint for overall survival (OS). However, this has not been evaluated under current standard of care regimens of chemotherapy in combination with targeted therapies. We conducted an analysis of published mCRC ...
Mawhinney Ellen - - 2013
Levetiracetam is a broad-spectrum antiepileptic drug (AED) which is currently licensed in the United States and the United Kingdom and Ireland for use as adjunctive treatment of focal-onset seizures and myoclonic seizures or generalized tonic-clonic seizures, occurring as part of generalized epilepsy syndromes. In the United Kingdom and Ireland, it ...
Shaheen Bashar W - - 2013
OBJECTIVES: To determine the prevalence of plasmid-mediated quinolone resistance (PMQR) determinants and investigate mutations in gyrase and topoisomerase genes that may contribute to increased fluoroquinolone resistance in canine and feline Escherichia coli isolates in the USA that displayed reduced susceptibility to extended-spectrum cephalosporins. This study was undertaken because previous epidemiological ...
Landau Ruth - - 2013
BACKGROUND:IV fentanyl is used as a labor analgesic; however, few studies have reported the effects of IV fentanyl for early labor analgesia. We evaluated the analgesic response to IV fentanyl according to the combined effect of the single-nucleotide polymorphisms rs1799971 (c.118A/G, p. 40Asn/Asp) of the µ-opioid receptor gene (OPRM1) and ...
Casarano Romeu - - 2013
The use of ionic liquids with fluoride anion (IL-F) is challenging because of side reactions. Neat 1-allyl-3-methylimidazolium fluoride (AlMeImF) is used as a solvent in microwave-assisted acylation of cellulose. The results are disappointing due to side reactions in the IL proper, and F(-) -mediated hydrolysis of the produced ester. A ...
Wu Tianjing - - 2013
Two novel dendrimers, 16T and 20T, based on 1,1,2,2-tetra(thiophen-2-yl)ethene (4T) as a new dendron, were efficiently synthesized via carbonylation, Suzuki, and McMurry reactions. All intermediates and title compounds were fully characterized by (1)H NMR, (13)C NMR, and HRMS. 4T and 16T were confirmed by X-ray single crystal analyses. In addition, ...
Fung Man Chiu - - 2013
The nasal route presents an enormous opportunity to exploit the highly vascularized respiratory airway for systemic drug delivery to provide more rapid onset of therapy and reduced drug degradation compared with conventional oral routes. The dynamics of atomization at low injection pressure is less known as typical spray atomization studies ...
Matsukura Keiichiro - - 2013
A novel viral disease of rice caused by Southern rice black-streaked dwarf virus (SRBSDV) has spread throughout East and Southeast Asia since the mid-2000s. Outbreaks of this viral disease occur yearly in southern parts of Japan concurrently with overseas migration of the planthopper vector Sogatella furcifera from southern China during ...
Fujino Tomoshige - - 2013
The compatibility of D-amino acids with peptide elongation during translation has been examined in several studies. However, some of the studies have reported that D-amino acids are incompatible with translation, whereas others have reported that D-amino acids are incorporated into polypeptides. Here, we have reevaluated the incorporation of a series ...
Villa Eric M - - 2013
Five new uranium phosphites, phosphates, and mixed phosphate-phosphite compounds were hydrothermally synthesized using H(3)PO(3) as an initial reagent. These compounds are Cs(4)[(UO(2))(8)(HPO(4))(5)(HPO(3))(5)]·4H(2)O (1), Cs[U(IV)(PO(4))(H(1.5)PO(4))](2) (2), Cs(4)[U(IV)(6)(PO(4))(8)(HPO(4))(HPO(3))] (3), Cs(10)[U(IV)(10)(PO(4))(4)(HPO(4))(14)(HPO(3))(5)]·H(2)O (4), and Cs(3)[U(IV)(4)(PO(4))(3)(HPO(4))(5)] (5). The first contains uranium(VI) and the latter four uranium(IV). Of the U(IV) structures, two have extensive disordering among ...
Schäfer Hans Hendrik - - 2013
The prevalence of complicated hypertension is increasing in America and Europe. This survey was undertaken to assess the status quo of primary care management of hypertension in patients with the high-risk comorbid diseases metabolic syndrome (MetS) and/or type 2 diabetes mellitus (non-insulin depending diabetes mellitus (NIDDM)). Data of anti-hypertensive treatment ...
Bremner P - - 2013
As electronic devices become increasingly complex, ensuring their reliable, fault-free operation is becoming correspondingly more challenging. It can be observed that, in spite of their complexity, biological systems are highly reliable and fault tolerant. Hence, we are motivated to take inspiration for biological systems in the design of electronic ones. ...
Chouinard-Castonguay Sarah - - 2013
FEW STUDIES HAVE INVESTIGATED WHETHER FAVORABLE EFFECTS OF LACTATION PERSIST AFTER WEANING AND PROTECT WOMEN WITH PRIOR GESTATIONAL DIABETES MELLITUS (GDM) AGAINST LATER DEVELOPMENT OF INSULIN RESISTANCE AND INSULIN SECRETION DEFECTS. OBJECTIVE: To investigate the impact of lactation duration on insulin and glucose response among women with prior GDM. Design/Methods: ...
Kobori Takuro - - 2013
Previously, we reported that repeated oral treatment with etoposide (ETP) causes attenuation of oral morphine analgesia through upregulation of ileal P-glycoprotein (P-gp) mediated by Ras homolog gene family, member A (RhoA) activation. However, the detailed mechanism of the increase in ileal P-gp via RhoA activation remains unknown. Recently, it has ...
Weng Qunhong - - 2013
Layered boron nitrides (BNs) are usually viewed as excellent protective coatings and reinforcing materials due to their chemical inertness and high mechanical strength. However, the attention paid to their potential applications in gas sorption, especially in case of hydrogen, has obviously been insufficient. Herein, a novel BN material, i.e. porous ...
Yu Rongqin - - 2013
OBJECTIVE: We examined the potential moderating role of Block's personality types (i.e., overcontrollers, undercontrollers, and resilients) on the longitudinal associations between adolescents' and their best friends' delinquency. METHOD: Across three annual waves, 497 Dutch adolescents (283 boys, M(Age) = 13 years at Wave 1) and their best friends reported on ...
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