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Olaru Florina F Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, - - 2013
Goodpasture disease is an autoimmune kidney disease mediated by autoantibodies against noncollagenous domain 1 (NC1) monomers of α3(IV) collagen that bind to the glomerular basement membrane (GBM), usually causing rapidly progressive glomerulonephritis (GN). We identified a novel type of human IgG4-restricted anti-GBM autoantibodies associated with mild nonprogressive GN, which specifically ...
Giang Kok Wai - - 2013
AimsThe aim of this study was to examine the short-term and long-term cumulative risk of coronary heart disease (CHD) and stroke separately based on age, sex, smoking status, systolic blood pressure, and total serum cholesterol.Methods and resultsThe Primary Prevention Study comprising 7174 men aged between 47 and 55 free from ...
Chen Zhaowei - - 2013
In this paper, we present a facile strategy to synthesize hyaluronic acid (HA) conjugated mesoporous silica nanoparticles (MSP) for targeted enzyme responsive drug delivery, in which the anchored HA polysaccharides not only act as capping agents but also as targeting ligands without the need of additional modification. The nanoconjugates possess ...
Bunker Brittany - - 2013
Abstract Populations of several species of gregarine parasites within a single host species, the damselfly Ischnura verticalis, were examined over the course of 1 season at 4 geographic localities separated by a maximum distance of 9.7 km. Gregarines, having a life cycle with both exogenous and endogenous stages, are subject ...
León Thierry - - 2013
A novel Ni-catalyzed carboxylation of benzyl halides with CO2 has been developed. The described carboxylation reaction proceeds under mild conditions (atmospheric CO2 pressure) at room temperature. Unlike other routes for similar means, our method does not require well-defined and sensitive organometallic reagents, thus becoming a user-friendly and operationally simple protocol ...
Redina Olga E - - 2013
The genetic basis of the stress-sensitive arterial hypertension was investigated using the quantitative trait loci (QTL) approach. Two groups of F(2) (inherited stress-induced arterial hypertension [ISIAH] × Wistar albino Glaxo [WAG]) hybrid males of different age (3-4 months old and 6 months old) were tested for blood pressure at rest ...
Malik Sabrina - - 2013
Premature infants exhibit neurodevelopmental delay and reduced growth of the cerebral cortex. However, the underlying mechanisms have remained elusive. Therefore, we hypothesized that neurogenesis in the ventricular and subventricular zones of the cerebral cortex would continue in the third trimester of pregnancy and that preterm birth would suppress neurogenesis. To ...
Hioki Hiroyuki - - 2013
Parvalbumin (PV)-producing fast-spiking neurons are well known to generate gamma oscillation by mutual chemical and electrical connections in the neocortex. Although it was clearly demonstrated that PV neurons form a dense gap junction network with each other not only at the proximal sites but also at the distal dendrites, comprehensive ...
Coomans Claudia P - - 2013
Circadian rhythm disturbances are observed in, e.g., aging and neurodegenerative diseases and are associated with an increased incidence of obesity and diabetes. We subjected male C57Bl/6J mice to constant light [12-h light-light (LL) cycle] to examine the effects of a disturbed circadian rhythm on energy metabolism and insulin sensitivity. In ...
Hossain Mohammad Lokman - - 2013
A CuI-catalyzed synthesis of 1, 3-disubstituted allenes from 1-alkynes by the reaction with various N-tosylhydrazones has been developed. This method, which uses readily available starting materials and is operationally simple, offers 1, 3-disubstituted allenes in moderate to good yields. The reaction also tolerates various functional groups.
King Lauren B - - 2013
Acinetobacter baumannii is an important nosocomial pathogen. Infections are often preceded by intubation or catheter use, promoting the formation of biofilm, and some strains are able to cause severe cases of bacteremia due to their ability to resist killing by complement. We identified a secreted serine Protease that provided resistance ...
Miao Yufeng - - 2013
Exploiting catalytic promiscuity: The proline-based enzyme 4-oxalocrotonate tautomerase (4-OT) promiscuously catalyzes asymmetric Michael-type additions of linear aldehydes-ranging from acetaldehyde to octanal-to trans-β-nitrostyrene in aqueous solvent. The presence of 1.4 mol % of 4-OT effected formation of the anticipated γ-nitroaldehydes in fair to good yields with dr values of up to 93:7 ...
Makowska Katarzyna Anna KA School of Molecular and Cellular Biology, University of Leeds, Leeds, - - 2013
The 7th Abercrombie Meeting took place in Oxford this past summer. It was organized by The Royal Microscopical Society with the support of The British Society for Cell Biology. Michael Abercrombie was a pioneer in the field of investigating cell behavior using time-lapse microscopy. The meeting was focused on "multi-dimensional ...
Salvador Beatriz - - 2013
Filoviruses are the cause of severe hemorrhagic fever in human and nonhuman primates. The envelope glycoprotein (GP), responsible for both receptor binding and fusion of the virus envelope with the host cell membrane, has been demonstrated to interact with multiple molecules in order to enhance entry into host cells. Here ...
Yanagimachi Ryuzo - - 2013
In some animals, such as fish, insects and cephalopods, the thick egg coat has a narrow canal--a micropyle--through which spermatozoa enter the eggs. In fish, there is no indication that spermatozoa are attracted by eggs from a distance, but once spermatozoa come near the outer opening of the micropyle, they ...
Christie Louise - - 2013
Although fragile X syndrome (FXS) is the commonest cause of inherited intellectual disability the mean age of diagnosis in Australia is 5.5 years. Newborn screening for FXS can provide an early diagnosis, preventing the "diagnostic odyssey", allowing access to early interventions, and providing reproductive information for parents. Parents of affected ...
Wengenroth Martina - - 2013
Absolute pitch (AP) perception is the auditory ability to effortlessly recognize the pitch of any given tone without external reference. To study the neural substrates of this rare phenomenon, we developed a novel behavioral test, which excludes memory-based interval recognition and permits quantification of AP proficiency independently of relative pitch ...
Travlou Nikolina A - - 2013
In the current study, the functionalization of graphite oxide (GO) with magnetic chitosan (Chm) was investigated in order to prepare a nanocomposite material (GO-Chm) for the adsorption of a reactive dye (Reactive Black 5). The explanation of mechanism's synthesis was attempted by employing various techniques (SEM/EDAX, FTIR, XRD, XPS, DTA, ...
Shao Weijian W Dept. of Physiology, SL39, Tulane Univ. Health Sciences Center, 1430 Tulane Ave., New Orleans, LA 70112, USA. - - 2013
In angiotensin II (ANG II) infusion hypertension, there is an augmentation of intratubular angiotensinogen (AGT) and ANG II leading to increased urinary AGT and ANG II excretion rates associated with tissue injury. However, the changes in urinary AGT and ANG II excretion rates and markers of renal injury during physiologically ...
Smith Amy C AC Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, SC 29208, - - 2013
Members of the transient receptor potential (TRP) channel superfamily, including the Ca(2+)-activated monovalent cation-selective TRP melastatin 4 (TRPM4) channel, have been recently identified in the urinary bladder. However, their expression and function at the level of detrusor smooth muscle (DSM) remain largely unexplored. In this study, for the first time ...
Fowlkes Jason D - - 2013
The effects of increased crowding and confinement on the mobility of individual fluorescent molecules were studied using Fluorescence Correlation Spectroscopy (FCS) in a microfluidic device with sealable femtolitre-volume chambers, and compared to three dimensional stochastic Monte Carlo simulations. When crowding and the degree of confinement were increased simultaneously, extended correlation ...
Greenberg Steven M - - 2013
A rather dark joke has it that a doctor is speaking with his patient, Mr. Jones, after examining him.
He Qi - - 2013
Centromeres and telomeres are both DNA/protein complex and essential functional components of eukaryotic chromosomes. Previous studies have shown that rice centromeres and telomeres are occupied by CentO satellite and G-rich telomere repeats, respectively. However, the protein components are not fully understood. DNA binding proteins associated with centromeric or telomeric DNAs ...
Kang Hyun - - 2013
BACKGROUND: Appropriate pain management affects outcome after hip fracture surgery. Although multimodal pain management is commonly used for pain control for patients undergoing elective surgery, few studies have evaluated its use in those undergoing hip fracture surgery. This prospective randomized study was designed to determine the clinical value of multimodal ...
Thomas Niclas - - 2013
SUMMARY: High throughput sequencing provides an opportunity to analyse the repertoire of antigen specific receptors with an unprecedented breadth and depth. However, the quantity of raw data produced by this technology requires efficient ways to categorise and store the output for subsequent analysis. To this end, we have defined a ...
Simões Eric A F - - 2013
Determining the viral etiology of respiratory tract infections (RTI) has been limited for the most part to specific primer PCR-based methods due to their increased sensitivity and specificity compared to other methods, such as tissue culture. However, specific primer approaches have limited the ability to fully understand the diversity of ...
Yang Jingshuai - - 2013
Covalently cross-linked polymer membranes were fabricated from poly(aryl sulfone benzimidazole) (SO(2) PBI) and poly(vinylbenzyl chloride) (PVBCl) as electrolytes for high-temperature proton-exchange-membrane fuel cells. The cross-linking imparted organo insolubility and chemical stability against radical attack to the otherwise flexible SO(2) PBI membranes. Steady phosphoric acid doping of the cross-linked membranes was ...
Li Jun - - 2013
The exothermic F + H2O → HF + OH reaction has a decidedly early (reactant-like) barrier. According to Polanyi's rules, translational energy would be more effective than vibrational energy in promoting such reactions. However, we demonstrate here using both quasi-classical trajectory and full-dimensional quantum wave packet methods on an accurate ...
Kong Yulong - - 2013
A facile carbocation-induced electrophilic cyclization reaction has been developed for the synthesis of 3-alkyl- or 3-allenyl-2-amidobenzofurans from o-anisole-substituted ynamides and diarylmethanol or 1,1-diarylprop-2-yn-1-ol.
Airoldi Cristina - - 2013
Amyloid peptides, Aβ1-40 and Aβ1-42, represent major molecular targets to develop potential drugs and diagnostic tools for Alzheimer's Disease (AD). In fact, oligomeric and fibrillar aggregates generated by these peptides are amongst the principal components of amyloid plaques found post mortem in patients suffering from AD. Rosmarinic acid has been ...
Yang Helen - - 2013
A sponge-like cotton fabric autonomously collects and releases water from fogs triggered by typical day-and-night temperature variations. The reversible switching between absorbing-superhydrophilic/releasing-superhydrophobic states results from structural changes of a temperature-responsive polymer grafted on the very rough fabric-surface. This material and concept presents a breakthrough into simple and versatile solutions for ...
Bawankar Praveen P Department of Biochemistry, Max Planck Institute for Developmental Biology, Tübingen, - - 2013
The CCR4-NOT complex plays a crucial role in post-transcriptional mRNA regulation in eukaryotes. This complex catalyzes the removal of mRNA poly(A) tails, thereby repressing translation and committing an mRNA to degradation. The conserved core of the complex is assembled by the interaction of at least two modules: the NOT module, ...
Fabre Alexandre - - 2013
ABSTRACT: Syndromic diarrhea/Tricho-hepato-enteric syndrome (SD/THE) is a rare and severe bowel disorder caused by mutation in SKIV2L or in TTC37, 2 genes encoding subunits of the putative human SKI complex. The estimated prevalence is 1/1,000,000 births and the transmission is autosomal recessive. The classical form is characterized by 5 clinical ...
Lucas Peter W PW Department of Bioclinical Sciences, Kuwait University, PO Box 24923, Safat 13110, Kuwait. - - 2013
The wear of teeth is a major factor limiting mammalian lifespans in the wild. One method of describing worn surfaces, dental microwear texture analysis, has proved powerful for reconstructing the diets of extinct vertebrates, but has yielded unexpected results in early hominins. In particular, although australopiths exhibit derived craniodental features ...
Zilber Yulia - - 2013
The Planar Cell Polarity (PCP) pathway controls multiple cellular processes during vertebrate development. Recently, the PCP pathway was implicated in ciliogenesis and in ciliary function. The primary cilium is an apically-projecting solitary organelle that is generated via polarized intracellular trafficking. Since it acts as a signaling nexus, defects in ciliogenesis ...
Goh William W Department of Obstetrics, Gynecology and Women's Health, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96826, USA. - - 2013
This study was designed to show whether placental relaxin (RLN), its receptor (RXFP1), or insulin-like peptide 4 (INSL4) might have altered expression in patients with placenta accreta. The baseline expression of their genes through gestation (n = 34) was quantitated in the placental basal plate (BP) and villous trophoblast (TR), ...
Bottomly Daniel D Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA. - - 2013
Determining the functional relevance of identified sequence variants in cancer is a prerequisite to ultimately matching specific therapies with individual patients. This level of mechanistic understanding requires integration of genomic information with complementary functional analyses to identify oncogenic targets and relies on the development of computational frameworks to aid in ...
Lutz Larissa - - 2013
Hypermutable (HPM) strains of Pseudomonas aeruginosa have been found at high frequencies in cystic fibrosis (CF) patients in Europe. We report the results of testing for HPM frequencies, mutator genotype, and antimicrobial resistance of P. aeruginosa strains from Brazilian CF patients. A modified disk diffusion technique was used to quantify ...
Gerardin Patrick - - 2013
ABSTRACT: INTRODUCTION: Long-lasting relapsing or lingering rheumatic musculoskeletal pain (RMSP) is the hallmark of Chikungunya virus (CHIKV) rheumatism (CHIK-R). Little is known on their prognostic factors. The aim of this prognostic study was to search the determinants of lingering or relapsing RMSP indicative of CHIK-R. METHODS: Three hundred and forty ...
Alroughani R - - 2013
Abstract Background: Chronic Cerebro-Spinal Venous Insufficiency (CCSVI) has been proposed to be associated with Multiple Sclerosis (MS). Zamboni et al reported significant improvement in neurological outcomes in MS patients who underwent Percutaneous Transluminal Angioplasty (PTA). Objectives: To retrospectively evaluate the neurological outcomes in MS patients who underwent PTA. Method: Relapsing remitting ...
Kaplinsky Chaim C Department of Pediatric Hematology-Oncology, The Edmond and Lily Safra Children's Hospital, The Chaim Sheba Medical Center, Tel Aviv University, Tel Aviv, - - 2013
Hypomagnesemia is not uncommon among children with malignancies. It is especially seen in association with certain medications and can be further complicated by the presence of diarrhea and malnutrition. Severe hypomagnesemia may cause disturbances in the neuromuscular and cardiovascular systems. All patients with hypomagnesemia should be supplemented with the mineral, ...
Holmes Jacinta A - - 2013
BACKGROUND AND AIM: IL28B genotype predicts response to pegylated-interferon (peg-IFN)-based therapy in chronic hepatitis C. However, the utility of IL28B genotyping in chronic hepatitis B (CHB) cohorts treated with peg-IFN is unclear. We investigated whether IL28B genotype is associated with peg-IFN treatment outcomes in a predominantly Asian CHB cohort. METHODS: ...
Kohlmann Anna - - 2013
Lactate dehydrogenase A (LDH-A) catalyzes the interconversion of lactate and pyruvate in the glycolysis pathway. Cancer cells rely heavily on glycolysis instead of oxidative phosphorylation to generate ATP, a phenomenon known as the Warburg effect. The inhibition of LDH-A by small molecules is therefore of interest for potential cancer treatments. ...
Ben-Shahar Osnat - - 2013
Anomalies in prefrontal cortex (PFC) function are posited to underpin difficulties in learning to suppress drug-seeking behavior during abstinence. Because group 1 metabotropic glutamate receptors (mGluRs) regulate drug-related learning, we assayed the consequences of extended access to intravenous cocaine (6 h/d; 0.25 mg/infusion for 10 d) on the PFC expression ...
Jin Xiaogao - - 2013
Adiponectin is a multifunctional cytokine that has a role in regulating inflammation. Here we determined whether adiponectin modulates ischemic acute kidney injury. Compared with wild-type mice, adiponectin-knockout mice were found to have lower serum creatinine and less tubular damage or apoptosis following ischemia/reperfusion injury. This latter process was associated with ...
Chang Fang-Yuan - - 2013
Natural product discovery by random screening of broth extracts derived from cultured bacteria often suffers from high rates of redundant isolation, making it ever more challenging to identify novel biologically interesting natural products. Here we show that homology-based screening of soil metagenomes can be used to specifically target the discovery ...
Song Saera S Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of - - 2013
Mutations in PINK1 (PTEN-induced putative kinase 1) are tightly linked to autosomal recessive Parkinson disease (PD). Although more than 50 mutations in PINK1 have been discovered, the role of these mutations in PD pathogenesis remains poorly understood. Here, we characterized 17 representative PINK1 pathogenic mutations in both mammalian cells and ...
Shepard Allan R - - 2013
Glaucoma and age-related macular degeneration are ocular diseases targeted clinically by anecortave acetate (AA). AA and its deacetylated metabolite, anecortave desacetate (AdesA), are intraocular pressure (IOP)-lowering and angiostatic cortisenes devoid of glucocorticoid activity but with an unknown mechanism of action. We used a methotrexate-anchored yeast three-hybrid (Y3H) technology to search ...
van Kruchten Roger - - 2013
Scott syndrome, a bleeding disorder caused by defective phospholipid scrambling, has been associated with mutations in the TMEM16F gene. The role of TMEM16F in apoptosis- or agonist-induced phosphatidylserine (PS) exposure was studied in platelets from a Scott syndrome patient and control subjects. Whereas stimulation of control platelets with the BH3-mimetic ...
Salcedo Suzana Pinto - - 2013
Brucellae replicate in a vacuole derived from the endoplasmic reticulum (ER) in epithelial cells, macrophages and dendritic cells. In animals, trophoblasts are also key cellular targets where brucellae efficiently replicate, in association with the ER. Therefore, we investigated the ability of Brucella spp. to infect human trophoblasts using both immortalized ...
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