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Fowlkes Jason D - - 2013
The effects of increased crowding and confinement on the mobility of individual fluorescent molecules were studied using Fluorescence Correlation Spectroscopy (FCS) in a microfluidic device with sealable femtolitre-volume chambers, and compared to three dimensional stochastic Monte Carlo simulations. When crowding and the degree of confinement were increased simultaneously, extended correlation ...
Greenberg Steven M - - 2013
A rather dark joke has it that a doctor is speaking with his patient, Mr. Jones, after examining him.
He Qi - - 2013
Centromeres and telomeres are both DNA/protein complex and essential functional components of eukaryotic chromosomes. Previous studies have shown that rice centromeres and telomeres are occupied by CentO satellite and G-rich telomere repeats, respectively. However, the protein components are not fully understood. DNA binding proteins associated with centromeric or telomeric DNAs ...
Kang Hyun - - 2013
BACKGROUND: Appropriate pain management affects outcome after hip fracture surgery. Although multimodal pain management is commonly used for pain control for patients undergoing elective surgery, few studies have evaluated its use in those undergoing hip fracture surgery. This prospective randomized study was designed to determine the clinical value of multimodal ...
Thomas Niclas - - 2013
SUMMARY: High throughput sequencing provides an opportunity to analyse the repertoire of antigen specific receptors with an unprecedented breadth and depth. However, the quantity of raw data produced by this technology requires efficient ways to categorise and store the output for subsequent analysis. To this end, we have defined a ...
Yang Jingshuai - - 2013
Covalently cross-linked polymer membranes were fabricated from poly(aryl sulfone benzimidazole) (SO(2) PBI) and poly(vinylbenzyl chloride) (PVBCl) as electrolytes for high-temperature proton-exchange-membrane fuel cells. The cross-linking imparted organo insolubility and chemical stability against radical attack to the otherwise flexible SO(2) PBI membranes. Steady phosphoric acid doping of the cross-linked membranes was ...
Li Jun - - 2013
The exothermic F + H2O → HF + OH reaction has a decidedly early (reactant-like) barrier. According to Polanyi's rules, translational energy would be more effective than vibrational energy in promoting such reactions. However, we demonstrate here using both quasi-classical trajectory and full-dimensional quantum wave packet methods on an accurate ...
Kong Yulong - - 2013
A facile carbocation-induced electrophilic cyclization reaction has been developed for the synthesis of 3-alkyl- or 3-allenyl-2-amidobenzofurans from o-anisole-substituted ynamides and diarylmethanol or 1,1-diarylprop-2-yn-1-ol.
Airoldi Cristina - - 2013
Amyloid peptides, Aβ1-40 and Aβ1-42, represent major molecular targets to develop potential drugs and diagnostic tools for Alzheimer's Disease (AD). In fact, oligomeric and fibrillar aggregates generated by these peptides are amongst the principal components of amyloid plaques found post mortem in patients suffering from AD. Rosmarinic acid has been ...
Yang Helen - - 2013
A sponge-like cotton fabric autonomously collects and releases water from fogs triggered by typical day-and-night temperature variations. The reversible switching between absorbing-superhydrophilic/releasing-superhydrophobic states results from structural changes of a temperature-responsive polymer grafted on the very rough fabric-surface. This material and concept presents a breakthrough into simple and versatile solutions for ...
Fabre Alexandre - - 2013
ABSTRACT: Syndromic diarrhea/Tricho-hepato-enteric syndrome (SD/THE) is a rare and severe bowel disorder caused by mutation in SKIV2L or in TTC37, 2 genes encoding subunits of the putative human SKI complex. The estimated prevalence is 1/1,000,000 births and the transmission is autosomal recessive. The classical form is characterized by 5 clinical ...
Carrasco Andres - - 2013
In contrast to numerous studies of transcallosal communication in visual and somatosensory cortices, the functional properties of interhemispheric connections between auditory cortical fields have not been widely scrutinized. Therefore, the purpose of the present investigation was to measure the magnitude and type (inhibitory/excitatory) of modulatory properties of core auditory fields ...
Nasr Samih H - - 2013
Little is known about the rare entities of heavy- and light-chain amyloidosis (AHL) and heavy-chain amyloidosis (AH). Here, we report the renal and hematological characteristics, pathology, and outcome of 16 patients with renal AH/AHL (5 with AH and 11 with AHL) and compare them with 202 patients with renal light-chain ...
Takagi Toshio - - 2013
We compared the survival rates in patients with metastatic renal cell carcinoma between the cytokine and molecular targeted therapy era. The study included 321 patients who were diagnosed with metastatic renal cell carcinoma between 1987 and 2011. The patients were divided into two groups according to when they started therapy ...
Hjortø Gertrud M - - 2013
The human cytomegalovirus encoded G-protein-coupled-receptor US28 is believed to participate in virus dissemination through modulation of cell migration and immune evasion. US28 binds different CC chemokines and the CX3C chemokine CX3CL1. Membrane anchored CX3CL1 is expressed by immune activated endothelial cells causing redirection of CX3CR1-expressing leukocytes in blood into sites ...
Sanders Jason L - - 2013
Telomeres are nucleoprotein caps flanking DNA. They are shortened by cell division and oxidative stress and are lengthened by the enzyme telomerase and DNA exchange during mitosis. Short telomeres induce cellular senescence. As an indicator of oxidative stress and senescence (2 processes thought to be fundamental to aging), telomere length ...
Erbay Ali Riza - - 2013
Hypertension terms "dipper" and "non-dipper" are propounded by the change that occurs during ambulatory blood pressure (BP) monitoring. The purpose of this study is to present whether the serum urotensin II levels are different in patients with dipper and non-dipper hypertension and to put forward the effects causing this difference, ...
Doufas Anthony G - - 2013
BACKGROUND:We have previously shown that red hair is associated with increased desflurane requirement for immobility, compared with dark hair. The effect of red hair on IV anesthetic requirement remains unknown. We tested the hypothesis that the propofol concentration in the effect site associated with half maximal electroencephalogram response, Ce(50), is ...
Magni Giuseppina - - 2013
BACKGROUND:Ketorolac tromethamine (ketorolac) is a nonsedating drug with potent analgesic and moderate anti-inflammatory activity, which does not increase the sedation level. The safety of ketorolac with respect to risk of bleeding has been demonstrated in large numbers of patients undergoing general surgery, yet comparable safety data for neurosurgical patients are ...
He Haiyang - - 2013
Rotavirus (RV) infection is the main cause of acute dehydrating diarrhea in infants and young children below 5 years old worldwide. RV infection causes a global shutoff of host proteins as many other viruses do. However, previous studies revealed that RV could selectively upregulated the expression of some host proteins ...
Bouchal Pavel - - 2013
Proteomics profiling of intact proteins based on MALDI-TOF MS and derived platforms has been used in cancer biomarker discovery studies. This approach suffers from number of limitations such as low resolution, low sensitivity and that no knowledge is available on the identity of the respective proteins in the discovery mode. ...
Hernández-Guerra Daniel - - 2013
A new general methodology for the synthesis of chiral vinylphosphonate and vinylphosphine oxide carbohydrate derivatives has been developed using the anomeric alkoxyl radical fragmentation reaction as the key step. The synthetic sequence proceeded via β-iodophosphonate and β-iodophosphine oxide intermediates, which may be interesting synthons for the introduction of phosphorus into ...
Oderda Gary M - - 2013
ABSTRACT Purpose: This retrospective study utilized a large, national hospital database to assess the impact of opioid-related adverse events (ORADE) on patient outcomes following selected surgical procedures known to require postoperative pain control. Methods: Outcomes of patients with administratively documented ORADE were compared to those without. Multivariate regression determined differences ...
Shen Yang - - 2013
Learning and memory require orchestrated regulation of both structural and functional synaptic plasticity in the hippocampus. While a neuropeptide alpha-melanocyte-stimulating hormone, α-MSH, has been implicated in memory acquisition and retention, the functional role of its cognate receptor, melanocortin-4 receptor (MC4R), in hippocampal-dependent synaptic plasticity has not been explored. In this ...
Wu Li-Hua - - 2013
The 2003 International Society of Nephrology/Renal Pathology Society (ISN/RPS) pathological classification system of lupus nephritis specified the importance of vascular damage and indicated this should be included in the diagnostic summary. Few pathological studies of lupus nephritis, however, focus on the patterns of renal vascular involvement. Here we assessed renal ...
Crémet Lise - - 2013
OBJECTIVES: This study reports details on Escherichia coli isolates recovered from a cystic fibrosis (CF) patient in order to understand how this pathogen adapts to and resists broad-spectrum antipseudomonal therapy in this context. METHODS: Five E. coli isolates were obtained from various clinical samples (airways, urine or dialysis catheter) over ...
Lim Sang Ho - - 2013
Four crystalline dimers of the type, Au(I)(2)(μ-PnP)(2)I(2), where PnP is PPh(2)(CH(2))(n)PPh(2) with n = 3, 4, 5, and 6 have been prepared and characterized by single-crystal X-ray diffraction and by (31)P NMR and infrared spectroscopy. Au(I)(2)(μ-P3P)(2)I(2) and Au(I)(2)(μ-P6P)(2)I(2) are centrosymmetric dimers with the planar Au(I)P(2)I units oriented in antiparallel fashion. ...
Ren Qinghua - - 2013
When compared with the established palladium and nickel catalyst systems, simple iron salts turn out to be highly efficient, cheap, toxicologically benign, and environmentally friendly precatalysts for a host of cross-coupling reactions of alkyl or aryl Grignard reagents. The inorganic Grignard reagent [Fe(MgX)2], where X corresponds to Br or I, ...
Wiermans Lotte - - 2013
Pulp & Oil: We report the unprecedented formation of de-aromatized lignin oil together with a white polysaccharide fraction when lignocellulose is treated with peracids, which are formed in situ by enzymes. A preliminary characterization of the lignin oil is provided, together with the evidence that the delignified lignocellulose is accessible to ...
Kennedy Paul E - - 2013
Cluster bombardments of 15 keV C60 on metal-organic interfaces composed of silver atoms and octatetraene molecules were modeled using molecular dynamics computer simulations. Dynamics revealed by the simulations include the formation of holes in the metal overlayers from which underlying organic molecules are sputtered predominantly by a rapid jet-like motion, ...
Alvarez-Baron Elena - - 2013
The large isoforms of the Rab3 interacting molecule (RIM) family, RIM1α/β and RIM2α/β, have been shown to be centrally involved in mediating presynaptic active zone function. The RIM protein family contains two additional small isoforms, RIM3γ and RIM4γ, which are composed only of the RIM-specific C-terminal C2B domain and varying ...
Jialal Ishwarlal - - 2013
Context:Adipose tissue dysregulation causing aberrant adipokine secretion contributes toward the proinflammatory state of metabolic syndrome (MetS). However, there are scant data on the role of novel adipokines in MetS.Objective:The aim of this study was to determine the levels of circulating and adipose tissue-secreted adipokines, chemerin, omentin-1, resistin, and visfatin in ...
Johnson Justin C - - 2013
Certain organic materials can generate more than one electron-hole pair per absorbed photon, a property that could revolutionize the prospects for solar energy. This process, called singlet fission, is one possible "exciton multiplication" scheme that could be useful in a variety of photovoltaic device designs from dye-sensitized solar cells to ...
Hemmerling Thomas M - - 2013
BACKGROUND:Ultrasound-guided nerve blocks are becoming a standard of modern anesthesia. We developed a robotic system, Magellan, to perform nerve blocks using a remote control center.METHODS:Thirteen patients were enrolled in this pilot study. The Magellan system consists of 3 main components: a joystick, a robotic arm, and a software control system. ...
Lepora Nathan F - - 2013
Biomimetics is a research field that is achieving particular prominence through an explosion of new discoveries in biology and engineering. The field concerns novel technologies developed through the transfer of function from biological systems. To analyze the impact of this field within engineering and related sciences, we compiled an extensive ...
Kimura Tetsuo - - 2013
Duodenal carcinoid is a rare tumor, the natural history of which has not yet been clearly clarified. Endoscopic resection is recommended for tumors of less than 1 cm in diameter, limited to submucosal layer and with a low incidence of lymph node or distant metastases,(1,2) although no consensus has been ...
Koppel Jonathan - - 2013
We examined and compared the predictors of autobiographical memory (AM) consistency and event memory accuracy across two publicly documented yet disparate public events: the inauguration of Barack Obama as the 44th president of the United States on January 20th 2009, and the emergency landing of US Airways Flight 1549, off ...
Stroobants Karen - - 2013
Hen-egg-white lysozyme (HEWL) is specifically cleaved at the Trp28-Val29 and Asn44-Arg45 peptide bonds in the presence of a Keggin-type [Ce(α-PW(11) O(39) )(2) ](10-) polyoxometalate (POM; 1) at pH 7.4 and 37 °C. The reactivity of 1 towards a range of dipeptides was also examined and the calculated reaction rates were comparable to ...
Negi Bharti - - 2013
This work relates to the development of a co-fermented product of sea buckthorn (Hippophae rhamnoides L.) with Saccharomyces cerevisiae and Issatchenkia orientalis. Besides malic acid degradation, the parameters of present production technology were also standardized with emphasis on the retainability of total phenolic content (TPC) of sea buckthorn juice. The ...
Zuñiga Ana - - 2013
Although not fully understood, molecular communication in the rhizosphere plays an important role regulating traits involved in plant-bacteria association. Burkholderia phytofirmans PsJN is a well-known plant growth promoting bacterium, which establishes rhizospheric and endophytic colonization in different plants. A competent colonization is essential for plant growth promoting effects produced by ...
Terada Dohiko - - 2013
The focused ion beam (FIB) technology has drawn considerable attention in diverse research fields. FIB can be used to mill samples at the nanometer scale by using an ion beam derived from electrically charged liquid gallium (Ga). This powerful technology with accuracy at the nanometer scale is now being applied ...
Basso Andrea - - 2013
Three in the spotlight: Irradiation promotes a general, three-component reaction between diazoketones, carboxylic acids, and isocyanides. The highly functionalized captodative olefin products of this reaction are versatile synthons for organic synthesis.
Spinner C D - - 2013
Cytomegalovirus (CMV) plays an important role in non-immunocompetent patients due to its high seroprevalence and life-long persistence. However, cases of severe CMV infections are also described in the immunocompetent. Here in particular, the gastrointestinal involvement is of major importance. We describe the case of a 29-year-old immunocompetent young man, who ...
Pinkaew Siwaporn - - 2013
Iron (Fe), zinc (Zn), and vitamin A (VA) deficiencies are common among children in developing countries and often occur in the same individual. Rice is widely consumed in the developing countries of Asia and the low phytate in polished rice makes it ideal for Zn and Fe fortification. Triple-fortified rice ...
Carroll Roger C - - 2013
BACKGROUND:Aspirin-resistant platelet activation in whole blood is attributable to a transcellular pathway not detected by isolated platelet aggregometry. Aspirin resistance as defined by urinary thromboxane levels is associated with increased risk for myocardial infarction or cardiac death. Whole blood point-of-care assays may also detect aspirin resistance.METHODS:We compared PlateletMapping® with VerifyNow® ...
Ha Jeung-Hoi - - 2013
Alternate frame folding (AFF) is a protein engineering methodology the purpose of which is to convert an ordinary binding protein into a molecular switch. The AFF modification entails duplicating an amino- or carboxy-terminal segment of the protein and appending it to the opposite end of the molecule. This duplication allows ...
Choy Pui Ying - - 2013
A palladium-catalyzed C((sp2))-H bond oxygenation reaction is described. This protocol represents the first example of a C-H bond cleavage/C-O bond formation sequence, by employing a ketone moiety as the directing group. With this new catalytic method, a variety of ortho-acylphenols can be easily accessed from arylketones.
Liu Jing - - 2013
We developed a novel smart multi-channel two-dimensional (2-D) micro-gas chromatography (μGC) architecture that shows promise to significantly improve 2-D μGC performance. In the smart μGC design, a non-destructive on-column gas detector and a flow routing system are installed between the first dimensional separation column and multiple second dimensional separation columns. ...
Park In-Hyeok - - 2013
Solvothermal reaction of Zn(NO(3) )(2) ⋅4 H(2) O, 1,4-bis[2-(4-pyridyl)ethenyl]benzene (bpeb) and 4,4'-oxybisbenzoic acid (H(2) obc) in the presence of dimethylacetamide (DMA) as one of the solvents yielded a threefold interpenetrated pillared-layer porous coordination polymer with pcu topology, [Zn(2) (bpeb)(obc)(2) ]⋅5 H(2) O (1), which comprised an unusual isomer of the well-known paddle-wheel ...
Kao Ming-Wei - - 2013
Pulmonary sequestration is a congenital anomaly of the lungs. We present the case of a patient whose initial symptom was mild dysphagia. Esophagoscopy showed the presence of a submucosal tumor in the lower-third section of the esophagus. The tumor was excised via video-assisted thoracoscopic surgery. The histopathology results indicated extrapulmonary ...
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