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Nakao Ryo R Division of Collaboration and Education, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Hokkaido, - - 2013
Ticks transmit a variety of viral, bacterial and protozoal pathogens, which are often zoonotic. The aim of this study was to identify diverse tick microbiomes, which may contain as-yet unidentified pathogens, using a metagenomic approach. DNA prepared from bacteria/archaea-enriched fractions obtained from seven tick species, namely Amblyomma testudinarium, Amblyomma variegatum, ...
Gosmain Yvan - - 2013
Type 2 diabetes is one of the most common diseases affecting 5 to 10% of the population in most countries; the progression of its prevalence is constant over the last 50 years in all countries of the world creating a major public health problem in term of disease management and ...
Zhu Tianwei - - 2013
Using density functional theory (DFT) and thermodynamic considerations we studied the equilibrium shape of Pt nanoparticles (NPs) under electrochemical conditions. We found that at very high oxygen coverage, obtained at high electrode potentials, the experimentally-observed tetrahexahedral (THH) NPs consist of high-index (520) faces. Since high-index surfaces often show higher (electro-)chemical ...
Kochańczyk Tomasz - - 2013
The minimal zinc hook peptide of Rad50 and its alanine mutants form highly stable Zn(ii) complexes. These peptides were successfully used as a small, efficient tag for reversible Zn(ii)-mediated protein homodimerization. The high stability, its biological consequences and potential applications in protein engineering are discussed.
Aeschbacher S - - 2013
We propose a two-step procedure for estimating multiple migration rates in an approximate Bayesian computation (ABC) framework, accounting for global nuisance parameters. The approach is not limited to migration, but generally of interest for inference problems with multiple parameters and a modular structure (e.g. independent sets of demes or loci). ...
Chang Yu-Hsiang - - 2013
Natural killer (NK) cells rely on surface receptors to distinguish healthy cells from cancer cells. We designed a receptor termed NKG2D-DAP10-CD3ζ that is composed of the NK cell activating molecule NKG2D plus two key signaling molecules, DAP10 and CD3ζ, and evaluated its capacity to promote cancer cell killing. Retroviral transduction ...
Jensen Rebekka Vibjerg - - 2013
Objectives. Through the hexosamine biosynthetic pathway (HBP) proteins are modified by O-linked-β-N-acetylglucosamine (O-GlcNAc), which acts as a stress sensor. Augmentation of O-GlcNAc confers cardioprotection against ischemia- reperfusion injury, but its role in ischemic preconditioning (IPC) is unknown. Azaserine and alloxan are unspecific blockers of the HBP and have been used ...
Sattler Sebastian - - 2013
This online panel study (n(t)(1) = 5,882; n(t)(2) = 3,486 (randomly selected)) used multiple metrics to assess the prevalence of the nonmedical use of prescription medication for enhancing cognitive performance among German university students in 2010. Rare events logistic regression revealed that increased cognitive test anxiety increased the prevalence of ...
Redmayne Mary - - 2013
ABSTRACT: BACKGROUND: Cellphone and cordless phone use is very prevalent among early adolescents, but the extent and types of use is not well documented. This paper explores how, and to what extent, New Zealand adolescents are typically using and exposed to active cellphones and cordless phones, and considers implications of ...
Mansfield Jessica - - 2013
Stimulated Raman scattering (SRS) has been applied to unstained samples of articular cartilage enabling the investigation of living cells within fresh tissue. Hyperspectral SRS measurements over the CH vibrational region showed variations in protein and lipid content within the cells, pericellular matrix and interterritorial matrix. Changes in the cells and ...
Abele Harald - - 2013
OBJECTIVE: To examine whether the cavum septi pellucidi (CSP) is larger in second and third trimester fetuses with chromosomal abnormalities than in euploid fetuses. METHODS: Retrospective study utilizing stored 2D images of second and third trimester fetuses between 18 and 40 week' gestation from the Department of prenatal medicine at ...
Dasgupta Rajdeep - - 2013
The onset of melting in the Earth's upper mantle influences the thermal evolution of the planet, fluxes of key volatiles to the exosphere, and geochemical and geophysical properties of the mantle. Although carbonatitic melt could be stable 250 km or less beneath mid-oceanic ridges, owing to the small fraction (∼0.03 wt%) ...
Gupta Janesh J School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, United - - 2013
Menorrhagia is a common problem, yet evidence to inform decisions about therapy is limited. In a pragmatic, multicenter, randomized trial, we compared the levonorgestrel-releasing intrauterine system (levonorgestrel-IUS) with usual medical treatment in women with menorrhagia who presented to their primary care providers. We randomly assigned 571 women with menorrhagia to ...
Canale A - - 2013
In this paper we describe acoustically the wing-fanning behaviour showed by the male of the braconid Psyttalia concolor towards females and other conspecific males. Psyttalia concolor is a synovigenic koinobiont larval-pupal endoparasitoid of many Tephritidae, used in olive crops to control the olive fruit fly, Bactrocera oleae. In this braconid ...
Xue F - - 2013
MicroRNA (miRNA) has an important role as a master regulator of gene expression in immune system and is upregulated during T cell differentiation, however its function is not clear yet. In this study, the contribution of miR-31 in T cell activation was investigated. miR-31 was upregulated during the activation of ...
Herce H D - - 2013
The spatial relationship, or degree of colocalization, between two or more types of molecules in live cells is commonly detected using fluorescence microscopy. This spatial distribution can be used to estimate the interaction between fluorescently labelled molecules. These interactions are usually quantified by analysing the correlation and/or the overlap between ...
Matthews Jacqueline M - - 2013
LIM-domain proteins are a large family of proteins that are emerging as key molecules in a wide variety of human cancers. In particular, all members of the human LIM-domain-only (LMO) proteins, LMO1-4, which are required for many developmental processes, are implicated in the onset or the progression of several cancers, ...
Cormode David P DP Radiology Department, University of Pennsylvania, 3400 Spruce Street, 1 Silverstein, Philadelphia, PA 19104, USA. - - 2013
Inorganic nanocrystals have myriad applications in medicine, including their use as drug or gene delivery complexes, therapeutic hyperthermia agents, in diagnostic systems and as contrast agents in a wide range of medical imaging techniques. In MRI, nanocrystals can produce contrast themselves, with iron oxides having been the most extensively explored, ...
Iannacone Michelle R - - 2013
Genus-β human papillomavirus (HPV) DNA has been detected in basal cell carcinoma (BCC) tumors, but most epidemiologic studies have not observed associations between genus-β HPV seropositivity and BCC. A clinic-based case-control study was conducted to investigate cutaneous HPV infection in BCC. BCC cases (n=224) were recruited from a dermatology clinic, ...
Brunasso A M G - - 2013
BACKGROUND: The International Psoriasis Council in 2007 considered palmoplantar pustulosis (PPP) as a separate condition from psoriasis, despite the presence of certain phenotypes common in both diseases. OBJECTIVE: To describe and compare demographic and clinical characteristics among PPP and palmoplantar plaque psoriasis. METHODS: Retrospective case-series study from 2005 to 2010. ...
Koukuntla Ramesh - - 2013
BACKGROUND: Nearly one third of all human genetic diseases are due to nonsense mutations that can result in truncated proteins. Nonsense suppressor tRNAs (NSTs) were proposed as valuable tools for gene therapy of genetic diseases caused by premature termination codons (PTCs). Although various strategies were adapted over the years to ...
Primack Brian A - - 2013
Associations between the emerging trend of waterpipe tobacco smoking and mental health among college students have not been sufficiently explored. This study analyzed data collected from 152 academic institutions that participated in the National College Health Assessment during the 2008-2009 academic year to examine associations between mental health and waterpipe ...
Ryan Daniel A - - 2013
A water-soluble deep cavitand recognized alkylammonium salts, including the drug amantadine hydrochloride, in spiked samples of human urine. The signals of the guests are detected by (1)H NMR upfield of 0 ppm and so occur in a spectroscopic window that is outside of the normal region and distinct from the ...
Wedekind Dirk - - 2013
ABSTRACT: BACKGROUND: Insecure early attachment experiences have been reported to play an important role in the manifestation in alcoholism. The purpose of this study was to investigate the relationship of attachment styles with anxiety, anxiety coping and dysfunctional personality styles, as well as with the prevalence of personality disorders, and ...
Debarbieux S - - 2013
BACKGROUND: New primary melanomas arising in stage IV melanoma patients under BRAF inhibitors have been recently reported. This raises the question of the nature of the earliest cellular events identifiable within pre-existing moles. Objectives: to use RCM to investigate changing moles in patients under Vemurafenib. METHODS: In the first part ...
Reiter Jakub - - 2013
New ionic liquids with an asymmetric anion, fluorosulfonyl-(trifluoromethanesulfonyl)imide (FTFSI), were prepared and their chemical-physical properties were investigated. The ionic liquids based on N-methyl-N-propylpyrrolidinium, PYR(13), N-butyl-N-methylpyrrolidinium, PYR(14), and N-methoxyethyl-N-methylpyrrolidinium, PYR(12O1), exhibit high electrochemical stability (>5.5 V on platinum) and thermal stability (>250 °C in N(2) and >200 °C in O(2)). Due ...
Shehzad Adeeb - - 2013
Curcumin (diferuloylmethane), an active constituent of turmeric, is a well-described phytochemical, which has been used since ancient times for the treatment of various diseases. The dysregulation of cell signaling pathways by the gradual alteration of regulatory proteins is the root cause of cancers. Curcumin modulates regulatory proteins through various molecular ...
El-Kheshen Ghadir - - 2013
Summary In genetics, a consanguineous marriage means union between couples who are related as second cousins or closer. The present cross-sectional study was carried out in order to illustrate the prevalence and types of consanguineous marriages in the Shi'a population living in widespread territories in Lebanon including the Bekaa Valley, ...
Shi Qiang Q Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78245-0549, USA. - - 2013
In this study, we used a large non-human primate model, the baboon, to establish a step-wise protocol to generate CD34+ endothelial progenitor cells (EPCs) from embryonic stem cells (ESCs) and to demonstrate their reparative effects. Baboon ESCs were sequentially differentiated from embryoid body cultures for 9 days and then were ...
Mitchell Gabriel J - - 2013
Gram-positive bacteria can transport molecules necessary for their survival through holes in their cell wall. The holes in cell walls need to be large enough to let critical nutrients pass through. However, the cell wall must also function to prevent the bacteria's membrane from protruding through a large hole into ...
Deane Emily C - - 2013
Postsynaptic endosomal trafficking has emerged as a principal regulatory mechanism of structural and functional plasticity of glutamatergic synapses. Recycling endosomes perform activity-dependent transport of AMPA receptors (AMPARs) and lipids to the postsynaptic membrane, activities that are known to contribute to long-term synaptic potentiation and hypothesized to subserve learning and memory ...
Barrett John A - - 2013
This phase 1 study was performed to determine the pharmacokinetics and ability to visualize prostate cancer in bone, soft-tissue, and the prostate gland using (123)I-MIP-1072 and (123)I-MIP-1095, novel radiolabeled small molecules targeting prostate-specific membrane antigen. METHODS: Seven patients with a documented history of prostate cancer by histopathology or radiologic evidence ...
Khomane Kailas S - - 2013
Polymorphs enable us to gain molecular insights into the compaction behaviour of pharmaceutical powders. Two polymorphs (α and γ) of indomethacin (IMC) were investigated for in-die and out-of-die compaction behavior using compressibility, tabletability and compactibility (CTC) profile, stress-strain relationship, Heckel, Kawakita and Walker equations. Compaction studies were performed on a ...
Sarnak Mark J MJ Division of Nephrology, Tufts Medical Center, Boston, MA, USA. - - 2013
There are few detailed data on cognition in patients undergoing dialysis. We evaluated the frequency of and risk factors for poor cognitive performance using detailed neurocognitive testing. In this cross-sectional cohort study, 314 hemodialysis patients from 6 Boston-area hemodialysis units underwent detailed cognitive assessment. The neuropsychological battery assessed a broad ...
Raverdy Violeta - - 2013
BACKGROUND: Vancomycin is increasingly used by continuous infusion, but few specific data are available about stability under practical conditions of preparation and use, and compatibility with other intravenous drugs commonly used in the routine hospital setting. METHODS: Vancomycin stability [defined as recovery ≥ 93% of the original content (validated HPLC assay)] ...
Leeansyah Edwin - - 2013
Human immunodeficiency virus (HIV)-infected patients on combination active antiretroviral therapy (cART) are at increased risk of age-related complications. We hypothesized that nucleos(t)ide reverse transcriptase inhibitors (NRTI) may contribute to accelerated aging in HIV-infected individuals on cART via inhibition of telomerase activity. Telomerase activity and telomere length (TL) were measured by ...
Nasrolahi Shirazi Amir - - 2013
Doxorubicin (Dox) is a hydrophilic anticancer drug that has short retention time due to the efficient efflux in some cancer cells (e.g., ovarian adenocarcinoma SK-OV-3). Cyclic [W(RW)4] and the corresponding linear peptide (RW)4 were conjugated with Dox through an appropriate linker to afford cyclic [W(RW)4]-Dox and linear (RW)4-Dox conjugates to ...
Chung In Sun - - 2013
BACKGROUND:Although anesthetic-induced inhibition of lipopolysaccharide (LPS)-induced lung injury has been recognized, the underlying mechanism is obscure. Some studies suggest that reactive oxygen species (ROS) by isoflurane play a crucial role for anesthetic-induced protective effects on the brain or the heart; however, it still remains controversial. In this study, we examined ...
Alexander Jacob - - 2013
Hepatocellular carcinoma (HCC) is a major complication of cirrhosis and has been increasing in incidence in recent years. Fatty liver disease is an increasingly common cause of chronic liver disease, and there have been several case reports of HCC in patients with non-cirrhotic fatty liver disease. However, there is limited ...
Koh Joyce S B - - 2013
BACKGROUND:The optimal choice for intervention for recalcitrant lateral elbow tendinopathy remains unclear as various treatment modalities have documented comparable results in the literature. PURPOSE:To explore the safety, tolerability, and early efficacy of a new minimally invasive mode of treatment that delivers focused, calibrated ultrasonic energy, effectively microresecting the pathological tendon ...
Rosen Michael J MJ Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, - - 2013
Patients suffering from ulcerative colitis (UC) exhibit chronic colonic inflammation caused by a dysregulated mucosal immune response and epithelial barrier disruption. Th2 cytokines, including IL-13, have been implicated in the pathogenesis of UC. IL-13 induces phosphorylation of STAT6, and we previously demonstrated increased epithelial p-STAT6 in children with UC. In ...
Tuengler Andreas - - 2013
Electromagnetic hypersensitivity (EHS) is an ill-defined term to describe the fact that people who experience health symptoms in the vicinity of electromagnetic fields (EMFs) regard them as causal for their complaints. Up to now most scientists assume a psychological cause for the suffering of electromagnetic hypersensitive individuals. This paper addresses ...
Wilson Glenn A - - 2013
The potential impact of subvisible particles (SVPs) in protein therapeutic products has received a great deal of attention recently. As a result, new analytical methods have emerged to characterize and quantify SVPs. Among these, flow imaging (also called flow microscopy) has been widely employed. As we have used both FlowCAM® ...
Bhattacharya Sankar - - 2013
Sulphur emission from a Victorian brown coal was quantitatively determined through controlled experiments in a continuously-fed drop tube furnace under three different atmospheres - pyrolysis, oxy-fuel combustion and carbon dioxide gasification conditions. The species measured were H2S, SO2, COS, CS2, and more importantly SO3. The temperature (873-1273 K) and gas ...
O'Mahony Shane - - 2013
Atom-scale molecular dynamics computer simulations are used to probe the structure, dynamics and energetics of alkylamine self-assembled monolayer (SAM) films on graphene, and to model the formation of molecular bilayers and protein complexes on the films. Routes toward the development and exploitation of functionalized graphene structures are detailed here, and ...
Remesal Efrén - - 2013
Populations of Sclerotium rolfsii, the causal organism of Sclerotium root-rot on a wide range of hosts, can be placed into mycelial compatibility groups (MCGs). In this study, we evaluated three different molecular approaches to unequivocally identify each of 12 previously identified MCGs. These included restriction fragment length polymorphism patterns of ...
El Hage Faten - - 2013
We identified that the antigen preprocalcitonin (ppCT) is recognized on a human lung carcinoma by a cytotoxic T lymphocyte clone derived from autologous tumor-infiltrating lymphocytes. The antigenic peptide ppCT(16-25) is encoded by the gene calcitonin-related polypeptide alpha (CALCA), which codes for CT and is overexpressed in several lung carcinomas compared ...
Sanders Honi H Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02254, - - 2013
Networks that produce persistent firing in response to novel input patterns are thought to be important in working memory and other information storage functions. One possible mechanism for maintaining persistent firing is dendritic voltage bistability in which the depolarized state depends on the voltage dependence of the NMDA conductance at ...
Westin Shannon N SN Department of Gynecologic Oncology and Reproductive Medicine, M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030, USA. - - 2013
Prevention and early detection remain essential to decreasing cancer mortality. Screening DNA in Pap smears has the potential to increase the rate of early detection of endometrial and ovarian cancers. In this issue of Science Translational Medicine, Kinde and colleagues use advanced sequencing technology to evaluate DNA to screen for ...
Citronberg Jessica J Department of Epidemiology, Emory University, Atlanta, Georgia, - - 2013
To estimate the effects of ginger on apoptosis, proliferation, and differentiation in the normal-appearing colonic mucosa, we randomized 20 people at increased risk for colorectal cancer to 2.0 g of ginger or placebo daily for 28 days in a pilot trial. Overall expression and distributions of Bax, Bcl-2, p21, hTERT, ...
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