Search Results
Results 451 - 500 of 3056
< 5 6 7 8 9 10 11 12 13 14 15 >
Gray S J - - 2013
Injection of adeno-associated virus (AAV) into the cerebrospinal fluid (CSF) offers a means to achieve widespread transgene delivery to the central nervous system, where the doses can be readily translated from small to large animals. In contrast to studies with other serotypes (AAV2, AAV4 and AAV5) in rodents, we report ...
Evans Benjamin A - - 2013
The naturally transformable bacterium Streptococcus pneumoniae is able to take up extracellular DNA and incorporate it into its genome. Maintaining natural transformation within a species requires that the benefits of transformation outweigh its costs. Although much is known about the distribution of natural transformation among bacterial species, little is known ...
Daniele Gennaro - - 2013
Capecitabine , an oral prodrug of 5-fluorouracil (5-FU), is adsorbed in its intact form through the intestine and metabolized to 5-FU in tumour cells. In metastatic breast cancer (MBC), capecitabine is an effective and well-tolerated therapeutic option both in monotherapy and in combination with chemotherapeutic or molecular-targeted agents. We summarized ...
Deng Hui H Department of Dermatology, University of Colorado, Denver, Aurora, Colorado 80045, - - 2013
Carboxyl-terminal binding protein 1 (CtBP1) has been shown to suppress the transcription of several tumor suppressors in vitro. Paradoxically, a previous report showed that CtBP1 mRNA was downregulated in melanoma. Using immunostaining, we found that a large percentage of human melanomas were positive for CtBP1 protein. Furthermore, we demonstrated that ...
Harte C B - - 2013
Cigarette smoking deleteriously affects erectile function, and conversely, quitting smoking improves erectile hemodynamics. Underlying mechanisms by which smoking (or reduction of smoking frequency) may affect erectile physiology are not well understood. This study examined the mediating role of heart rate variability (HRV; a marker of sympathovagal balance) among a sample ...
Shi Qiang Q Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78245-0549, USA. - - 2013
In this study, we used a large non-human primate model, the baboon, to establish a step-wise protocol to generate CD34+ endothelial progenitor cells (EPCs) from embryonic stem cells (ESCs) and to demonstrate their reparative effects. Baboon ESCs were sequentially differentiated from embryoid body cultures for 9 days and then were ...
García-Gutiérrez Laura L Instituto de Hortofruticultura Subtropical y Mediterránea 'La Mayora'-IHSM-UMA-CSIC, Departamento de Microbiología, Universidad de Málaga, Bulevar Louis Pasteur 31-Campus Universitario de Teatinos, 29071 Málaga, - - 2013
Biological control of plant diseases has gained acceptance in recent years. Bacillus subtilis UMAF6639 is an antagonistic strain specifically selected for the efficient control of the cucurbit powdery mildew fungus Podosphaera fusca, which is a major threat to cucurbits worldwide. The antagonistic activity relies on the production of the antifungal compounds ...
Ruhal Rohit - - 2013
The current knowledge of trehalose biosynthesis under stress conditions is incomplete and needs further research. Since trehalose finds industrial and pharmaceutical applications, enhanced accumulation of trehalose in bacteria seems advantageous for commercial production. Moreover, physiological role of trehalose is a key to generate stress resistant bacteria by metabolic engineering. Although ...
De Vrieze Jo J Laboratory of Microbial Ecology and Technology (LabMET), Ghent University, Coupure Links 653, B-9000, Gent, - - 2013
Anaerobic digestion is an environmental key technology in the future bio-based economy. To achieve functional stability, a minimal microbial community diversity is required. This microbial community should also have a certain 'elasticity', i.e. the ability to rapidly adapt to suboptimal conditions or stress. In this study it was evaluated whether ...
Friman Hen H Department of Chemical Engineering and Biotechnology, Ariel University Center, Ariel, 40700, - - 2013
A microbial fuel cell (MFC) was operated with a pure culture of Cupriavidus basilensis bacterial cells growing in the anode compartment in a defined medium containing acetate or phenol. Operating this mediator-less MFC under a constant external resistor of 1 kΩ with acetate or phenol led to current generation of ...
Geneletti S S Department of Statistics, London School of Economics and Political Science, Houghton Street, London, WC2A 2AE, - - 2013
Case-control studies are particularly prone to selection bias, which can affect odds ratio estimation. Approaches to discovering and adjusting for selection bias have been proposed in the literature using graphical and heuristic tools as well as more complex statistical methods. The approach we propose is based on a survey-weighting method ...
Furmanski Anna L AL Immunobiology Unit, Institute of Child Health, University College London, London, - - 2013
Here we present a mouse model for T-cell targeting of hair follicles, linking the pathogenesis of alopecia to that of depigmentation disorders. Clinically, thymus transplantation has been successfully used to treat T-cell immunodeficiency in congenital athymia, but is associated with autoimmunity. We established a mouse model of thymus transplantation by ...
Gupta Janesh J School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, United - - 2013
Menorrhagia is a common problem, yet evidence to inform decisions about therapy is limited. In a pragmatic, multicenter, randomized trial, we compared the levonorgestrel-releasing intrauterine system (levonorgestrel-IUS) with usual medical treatment in women with menorrhagia who presented to their primary care providers. We randomly assigned 571 women with menorrhagia to ...
Oram S H SH Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust and MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, - - 2013
LMO1 is a transcriptional regulator and a T-acute lymphoblastic leukaemia (T-ALL) oncogene. Although first identified in association with a chromosomal translocation in T-ALL, the ectopic expression of LMO1 occurs far more frequently in the absence of any known mutation involving its locus. Given that LMO1 is barely expressed in any ...
Ray Sutapa S Department of Internal Medicine, Endocrinology Division, University of Texas Medical Branch, Galveston, Texas 77555-1060, USA. - - 2013
The molecular mechanisms behind the pathogenesis of postburn hypertrophic scar (HS) remain unclear. Here, we investigate the role of the IL-6 trans-signaling-signal transducer and activator of transcription (STAT)3 pathway in HS fibroblasts (HSFs) derived from post-burn HS skin. HSF showed increased Tyr 705 STAT3 phosphorylation compared with normal fibroblast (NF) ...
Menting John G JG Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, - - 2013
Insulin receptor signalling has a central role in mammalian biology, regulating cellular metabolism, growth, division, differentiation and survival. Insulin resistance contributes to the pathogenesis of type 2 diabetes mellitus and the onset of Alzheimer's disease; aberrant signalling occurs in diverse cancers, exacerbated by cross-talk with the homologous type 1 insulin-like ...
Ghosh Asish K AK Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, - - 2013
Fibrosis, the hallmark of systemic sclerosis (SSc), is characterized by persistent fibroblast activation triggered by transforming growth factor-β (TGF-β). As the acetyltransferase p300 has a key role in fibrosis and its availability governs the intensity of fibrotic responses, we investigated p300 expression in SSc and the molecular basis of its ...
Houchi Hakim H Groupe de Recherche sur l'Alcool & les Pharmacodépendances, INSERM ERi, UFR de Pharmacie, Université de Picardie Jules Verne, France. - - 2013
There is emerging evidence that the adenosinergic system might be involved in drug addiction and alcohol dependence. We have already demonstrated the involvement of A2A receptors (A2AR) in ethanol-related behaviours in mice. Here, we investigated whether the A2AR agonist CGS 21680 can reduce ethanol operant self-administration in both non-dependent and ...
Kaganovich Natalya N Department of Speech, Language, and Hearing Sciences, Purdue University, 500 Oval Drive, West Lafayette, IN 47907-2038, USA. - - 2013
Using electrophysiology, we have examined two questions in relation to musical training - namely, whether it enhances sensory encoding of the human voice and whether it improves the ability to ignore irrelevant auditory change. Participants performed an auditory distraction task, in which they identified each sound as either short (350 ...
Wang H H Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, - - 2013
Concerns about the geometric accuracy of MRI in radiation therapy (RT) have been present since its invention. Although modern scanners typically have system levels of geometric accuracy that meet requirements of RT, subject-specific distortion is variable, and methods to in vivo assess and control patient-induced geometric distortion are not yet ...
Xu Stanley S The Institute for Health Research, Kaiser Permanente Colorado, Denver, CO, USA. - - 2013
In the examination of the association between vaccines and rare adverse events after vaccination in postlicensure observational studies, it is challenging to define appropriate risk windows because prelicensure RCTs provide little insight on the timing of specific adverse events. Past vaccine safety studies have often used prespecified risk windows based ...
Hirano Makito - - 2013
OBJECTIVE: The purpose of this study was to find mutations in the SQSTM1 gene encoding p62 in Japanese patients with amyotrophic lateral sclerosis (ALS), since this gene has been recently identified as a causative gene for familial and sporadic ALS in the United States. METHODS: We sequenced this gene in ...
Thomas Arun Zachariah - - 2013
Introduction Laser technology presents a promising alternative to achieve tumor excision and renal hemostasis with or without hilar occlusion, yet its use in partial nephrectomy (PN) has not been significantly evaluated. We prospectively evaluated the Thulium:YAG (Th:YAG) laser in laparoscopic partial nephrectomy (LPN) in our institution over a 1 year ...
Uehara Kazuhiro - - 2013
Effects of isolobal heteroatoms in divanadium-substituted γ-Keggin-type polyoxometalates, (TBA)(4)[γ-XV(2)W(10)O(38)(μ-OH)(2)] 1(X) and (TBA)(4)[γ-XV(2)W(10)O(38)(μ-O)] 2(X) (where X = Ge or Si), on (OV)(2)(μ-OH)(2) and (OV)(2)(μ-O) core structures and transformations from 2(X) to 1(X) have been investigated. X-ray crystallography of 1(X) and 2(X) reveals that larger Ge (covalent radius 1.22 Å; covalent radius ...
Youn Duck Hyun - - 2013
The development of an efficient noble-metal-free counter electrode is crucial for possible applications of quantum-dot-sensitized solar cells (QDSSCs). Herein, we present TiN nanoparticles on a carbon nanotube (CNT)-graphene hybrid support as a noble-metal-free counter electrode for QDSSCs employing a polysulfide electrolyte. The resulting TiN/CNT-graphene possesses an extremely high surface roughness, ...
Blum Mariela A - - 2013
Gastric cancer continues to be a fatal disease with majority of cases presenting in late stages. For patients with advanced disease, we can only recommend palliative therapy. For localized gastric cancer, the approaches vary in various regions of the world. In western countries, preoperative chemotherapy or adjuvant chemo-radiation is preferred; ...
Wang Tianlu - - 2013
To surmount the challenges of the locus determination and accurate quantification of 5MedC in DNA fragments that contain multiple 5mC residues, and distinguishing between 5MedC and 5hmdC, we designed and synthesised two N-halogeno-N-sodiobenzenesulfonamide reagents that provide a new chemical method of probing 5MedC in DNA in this study. This sensitive ...
Kalantari Kambiz - - 2013
Accurate assessment of a patient's volume status, as well as whether they will respond to a fluid challenge with an increase in cardiac output, is a critical task in the care of critically ill patients. Despite this, most decisions regarding fluid therapy are made either empirically or with limited and ...
Teo Melissa C C - - 2013
Cancer is the leading cause of mortality in Singapore. The age-standardized incidence rates continue to increase as the population grows and ages, and the influence of environmental and lifestyle choices bear their consequences. The increase is most marked in colorectal, breast and prostate cancers, mirroring the most common cancers seen ...
Incrocci Ryan - - 2013
Epstein-Barr Virus (EBV) latently-infected B cells are the precursors of EBV-associated malignancies. EBV-infection induces the production of pro-survival and anti-inflammatory cytokines that may be important in the transition between latency and malignancy. One EBV protein, LMP2A, can be detected in both latently-infected resting B cells and in EBV-associated malignancies. Therefore, ...
Karnes Jason H - - 2013
ABSTRACT: BACKGROUND: Recently, the high-mobility group A1 gene (HMGA1) variant IVS5-13insC has been associated with type 2 diabetes, but reported associations are inconsistent and data are lacking in Hispanic and African American populations. We sought to investigate the HMGA1-diabetes association and to characterize IVS5-13insC allele frequencies and linkage disequilibrium (LD) ...
Chen Yu-Wen - - 2013
BACKGROUND:The underlying mechanism of exercise on the development of diabetes-associated neuropathic pain is not well understood. We investigated in rats whether exercise regulates the functional recovery and heat shock protein 72 (Hsp72), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 expression in streptozotocin (STZ)-induced diabetes.METHODS:Male Wistar rats were divided into 4 ...
Vicenzini Edoardo - - 2013
Cardioembolic stroke is generally caused by intracranial artery occlusion. Clots may be identified in the intracranial vessels by means of conventional neuroimaging in the acute phase. High-resolution ultrasonography may show some features suggestive of cardiac emboli when occluding extracranial carotid arteries. We describe a patient with cardioembolic ischemic stroke in ...
Lynn Jiun-Jen - - 2013
Febrile neutropenia caused by chemotherapy is a frequent medical emergency associated with severe complications in the emergency department (ED). Timely administration of antibiotics is believed to improve patient outcomes for several infectious diseases such as pneumonia and sepsis but has not been thoroughly evaluated for reducing risk of complications in ...
Lisón Purificación - - 2013
Viroids are single-stranded, circular, non-coding RNAs that infect plants, causing devastating diseases. In this work, we employed two-dimensional DIGE, followed by mass spectrometry identification, to analyze the response of tomato plants infected by Citrus exocortis viroid (CEVd). Among the differentially expressed proteins detected, 45 were successfully identified and classified into ...
Etemadifar Masoud - - 2013
Abstract: Background: Fatigue is one of the common complaints of multiple sclerosis (MS) patients and its treatment is relatively unclear. Ginseng is one of the herbal medicines possessing anti-fatigue properties and its administration in MS for such a purpose has been scarcely evaluated. The purpose of this study was to ...
Murri Mora - - 2013
BACKGROUNDOxidative stress might be associated with polycystic ovary syndrome (PCOS), but relatively small studies published to date do not permit reaching a definitive conclusion. We aimed at conducting a systematic review and meta-analysis of studies evaluating circulating markers of oxidative stress in patients with PCOS.METHODSWe conducted a systematic review of ...
Younce Craig - - 2013
Hyperglycemia-induced cardiomyocyte apoptosis contributes to diabetic cardiomyopathy. Glucagon-like peptide-1 (Glp1) receptor (Glp1r) agonists improve cardiac function and survival in response to ischemia-reperfusion and myocardial infarction. The present studies assessed whether Glp1r activation exerts direct cardioprotective effects in response to hyperglycemia. Treatment with the Glp1r agonist Exendin-4 attenuated apoptosis in neonatal ...
Dong Lili - - 2013
MORE AXILLARY BRANCHING 2 (MAX2), initially identified in Arabidopsis thaliana, is a key regulatory gene in strigolactone signal transduction. Three orthologs of MAX2 were cloned from Dendranthema grandiflorum (DgMAX2a, b, and c). Each of the genes has an open reading frame of 2,049 bp and encodes 682 amino acid proteins. ...
Nasr Samih H - - 2013
In the past, most cases of bacterial infection-related glomerulonephritis (IRGN) occurred in children following streptococcal upper respiratory tract or skin infections and were called postinfectious GN. Over the past 3 decades, there has been an important shift in epidemiology, bacteriology, and outcome of IRGN. A significant percentage of cases now ...
Fleming-Dutra Katherine E - - 2013
Background. Because pneumococcal pneumonia was prevalent during previous influenza pandemics, we evaluated invasive pneumococcal pneumonia (IPP) rates during the 2009 influenza A(H1N1) pandemic.Methods. We identified laboratory-confirmed, influenza-associated hospitalizations and IPP cases (pneumococcus isolated from normally sterile sites with discharge diagnoses of pneumonia) using active, population-based surveillance in the U.S. We compared IPP ...
Park Se Jin - - 2013
OBJECTIVES/HYPOTHESIS: Hydrogen sulfide (H(2) S), the third endogenous gaseous transmitter, may be a crucial mediator in airway hyper-responsiveness and airway inflammation, including asthma. To elucidate the role of H(2) S in allergic rhinitis, the present study was undertaken to determine the level of expression of H(2) S in healthy nasal ...
Sarraj Mai A - - 2013
TGFBR3 (betaglycan), a TGFbeta superfamily co-receptor, is essential for normal seminiferous cord and Leydig cell development in the fetal mouse testis and has been related to testicular dysgenesis syndrome in men. However, the mechanisms underlying TGFBR3-regulated testis development are unclear. We tested the hypothesis that loss of Tgfbr3 compromises the ...
Kim Hack-Lyoung - - 2013
ABSTRACT: BACKGROUND: The aim of this study is to investigate the association between arterial stiffness and left ventricular filling pressure in an apparently healthy Korean population. METHODS: A total of 115 healthy subjects without known cardiovascular risk factors or overt heart disease who underwent both transthoracic echocardiography and brachial-ankle pulse ...
Error Marc E - - 2013
Objectives(1) Determine the amount of exposure to otolaryngology in medical training of non-otolaryngology residents. (2) Evaluate the general otolaryngic knowledge in these residents.Study DesignCross-sectional survey.SettingAcademic medical center.Subjects and MethodsA 10-question multiple-choice quiz was given to residents in family practice, pediatrics, emergency medicine, and internal medicine during scheduled educational conferences. Residents ...
Fowlkes Jason D - - 2013
The effects of increased crowding and confinement on the mobility of individual fluorescent molecules were studied using Fluorescence Correlation Spectroscopy (FCS) in a microfluidic device with sealable femtolitre-volume chambers, and compared to three dimensional stochastic Monte Carlo simulations. When crowding and the degree of confinement were increased simultaneously, extended correlation ...
Greenberg Steven M - - 2013
A rather dark joke has it that a doctor is speaking with his patient, Mr. Jones, after examining him.
He Qi - - 2013
Centromeres and telomeres are both DNA/protein complex and essential functional components of eukaryotic chromosomes. Previous studies have shown that rice centromeres and telomeres are occupied by CentO satellite and G-rich telomere repeats, respectively. However, the protein components are not fully understood. DNA binding proteins associated with centromeric or telomeric DNAs ...
Kang Hyun - - 2013
BACKGROUND: Appropriate pain management affects outcome after hip fracture surgery. Although multimodal pain management is commonly used for pain control for patients undergoing elective surgery, few studies have evaluated its use in those undergoing hip fracture surgery. This prospective randomized study was designed to determine the clinical value of multimodal ...
Thomas Niclas - - 2013
SUMMARY: High throughput sequencing provides an opportunity to analyse the repertoire of antigen specific receptors with an unprecedented breadth and depth. However, the quantity of raw data produced by this technology requires efficient ways to categorise and store the output for subsequent analysis. To this end, we have defined a ...
< 5 6 7 8 9 10 11 12 13 14 15 >