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Nathan Hari H From the Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, - - 2013
We sought to quantify the use of and analyze factors predictive of receipt of surgical therapy for early hepatocellular carcinoma (HCC). The incidence of HCC is increasing, and the options for surgical therapy for early HCC have expanded, but the use of surgical therapy for early HCC has not been ...
Corso Phaedra S PS Department of Health Policy and Management, College of Public Health, University of Georgia, 110 E. Clayton St., Suite 300, Athens, GA 30602-5001, USA. - - 2013
Programmatic cost analyses of preventive interventions commonly have a number of methodological difficulties. To determine the mean total costs and properly characterize variability, one often has to deal with small sample sizes, skewed distributions, and especially missing data. Standard approaches for dealing with missing data such as multiple imputation may ...
Montealegre Jane R JR Division of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, TX, USA, - - 2013
While Hispanics in the U.S. are a population with significant within-group heterogeneity, epidemiologic studies often aggregate Hispanics into one homogenous group without considering differences by nativity. The objective of this study is to evaluate nativity differences in the risk behavior profile associated with prevalent high risk human papillomavirus (HR-HPV) among ...
Krishnaveni G V GV Epidemiology Research Unit, CSI Holdsworth Memorial Hospital, Mysore, South - - 2014
Prenatal programming of the hypothalamic-pituitary-adrenal (HPA) axis may link reduced foetal growth with higher adult chronic disease risk. South Asians have a high prevalence of low birth weight and a thin-fat phenotype, which is associated with subsequent type 2 diabetes and the metabolic syndrome. Altered HPA activity could be one ...
Thiramanas Raweewan R National Nanotechnology Center, National Science and Technology Development Agency, Thailand Science Park, Pathum Thani, 12120, - - 2013
Polystyrene (PS) nanoparticle (NP) copolymerized with acrylic acid (AA) and coloured monomer, i.e. 2,3,6,7-tetra(2,2'-bithiophene)-1,4,5,8-naphthalenetetracarboxylic-N,N'-di(2-methylallyl)-bisimide (ALN8T), was synthesized via the miniemulsion polymerization. Before applying for malaria antigen detection, the blue NP was conjugated with human polyclonal malaria IgG antibody (Ab) specific to Plasmodium falciparum. For the conjugation, three methods, i.e. physical ...
Rossman Matthew J MJ Geriatric Research, Education, and Clinical Center, George E Whalen VA Medical Center, Salt Lake City, UT 84148, - - 2013
Oxidative stress may contribute to exercise intolerance in patients with chronic obstructive pulmonary disease (COPD). This study sought to determine the effect of an acute oral antioxidant cocktail (AOC, vitamins C and E, and alpha-lipoic acid) on skeletal muscle function during dynamic quadriceps exercise in COPD. Ten patients with COPD ...
Abbott Sharon A SA Population Council, New York, NY, USA. - - 2013
Female sex workers (FSWs) were recruited for a 4-month placebo vaginal gel trial in Nellore, India. Two experiments explored if prior knowledge of biomarkers for unprotected sex and insertion of gel applicators would yield more accurate self-reports. A third experiment compared self-reports of gel use and adherence levels between FSWs ...
Kraus Michael R MR Medizinische Klinik und Poliklinik II, Department of Gastroenterology, University of Würzburg, Würzburg, - - 2013
Earlier studies have suggested neurocognitive impairment in patients with chronic hepatitis C virus (HCV) infection even before liver cirrhosis has developed. Since these deficits might be reversible after successful antiviral therapy, we analyzed the long-term course of neurocognitive parameters in HCV patients with and without successful virus elimination by an ...
Xia Min M Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, Guangdong Province, - - 2013
Recent studies have revealed the essential role of retinol binding protein 4 (RBP4) in insulin resistance. However, the impact of RBP4 on aberrant lipogenesis, the common hepatic manifestation in insulin resistance states, and the underlying mechanism remain elusive. The present study was designed to examine the effect of RBP4 on ...
Babcock Ben B The American Registry of Radiologic Technologists, 1255 Northland Drive, St. Paul, MN, 55120, USA. - - 2013
This report summarizes the performance of the Imaging Informatics Professional (IIP) examination from 2009 to 2011 (six exam administrations). Results show that the IIP exam is a reliable measuring instrument that is functioning well to consistently classify candidates as passing or failing. An analysis of the section scores revealed that ...
Taylor Victoria M VM Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, (M3-B232), Seattle, WA 98109, USA. - - 2013
Cambodian Americans have high rates of chronic hepatitis B virus (HBV) infection. However, only about one-half of Cambodian Americans have been serologically tested for HBV. We conducted a randomized controlled trial to evaluate the impact of a lay health worker (LHW) intervention on HBV testing and knowledge levels among Cambodian ...
Wooten Joshua S JS Division of Atherosclerosis and Vascular Biology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, - - 2013
Patients with dyslipidemia associated with HIV-1 infection and highly active antiretroviral therapy (HAART) have elevated levels of Lp-PLA2 and CCL5/regulated on activation, normal T-cell expressed and secreted (RANTES), which may increase the risk of cardiovascular disease. This study aimed to determine whether an intensive diet and exercise (D/E) program, independently ...
Siegler Ilene C IC Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA. - - 2013
Marital status is associated with survival. The aims of this study are to evaluate marital history and timing on mortality during midlife, test the role of pre-marital personality, and quantify the role of health risk behaviors. Cox proportional hazard models were run with varying classifications of marital history and sets ...
Walker Marcella D MD Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, - - 2013
Compared to white women, premenopausal Chinese-American women have more plate-like trabecular (Tb) bone. It is unclear whether these findings are relevant to postmenopausal women and if there are racial differences in the deterioration of bone microarchitecture with aging. We applied individual trabecula segmentation and finite element analysis to high-resolution peripheral ...
Ensrud Kristine E KE Department of Medicine, University of Minnesota, Minneapolis, MN, USA. - - 2013
To test the hypothesis that older women with higher cystatin C are at increased risk of hip fracture independent of traditional risk factors including hip bone mineral density (BMD), we performed a case-cohort analysis nested in a cohort of 4709 white women attending a Year 10 (1997-1998) examination of the ...
Hoy Jennifer J The Alfred Hospital and Monash University, Melbourne, Australia. - - 2013
Bone mineral density (BMD) declines significantly in HIV patients on antiretroviral therapy (ART). We compared the effects of intermittent versus continuous ART on markers of bone turnover in the Body Composition substudy of the Strategies for Management of AntiRetroviral Therapy (SMART) trial and determined whether early changes in markers predicted ...
Drummond Michael Bradley MB Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA. - - 2013
As survival with HIV infection improves, HIV-infected individuals appear to be susceptible to development of chronic diseases, including restrictive and obstructive lung diseases. We sought to determine the independent association of HIV infection on lung function decline. Longitudinal analysis of the AIDS Linked to the Intravenous Experience study, an observational ...
Maillette de Buy Wenniger Lucas J LJ Department of Gastroenterology & Hepatology and Tytgat Institute of Liver and Intestinal - - 2013
Immunoglobulin G4 (IgG4)-associated cholangitis (IAC) is a manifestation of the recently discovered idiopathic IgG4-related disease. The majority of patients have elevated serum IgG4 levels and/or IgG4-positive B-cell and plasma cell infiltrates in the affected tissue. We hypothesized that clonally expanded, class-switched IgG4-positive B cells and plasma cells could be causal ...
Reiser Arnost A Department of Chemical and Biological Engineering of the Polytechnic Institute of New York University, 6 Metrotech Center, Brooklyn, NY 11201, USA. - - 2013
In an earlier study of the effect of transition metal ions on the production of singlet oxygen by dyes it was found that four ions, namely Cu(2+), Ni(2+), Co(2+) and Co(3+) suppress singlet oxygen production altogether, provided the dyes are made ligands in coordination complexes of the ions. By this ...
Siow Wei Ming WM Orthopaedic Department, Singapore General Hospital, Outram Road, Singapore, 169608, Singapore. - - 2013
There is marked racial disparity in TKA use rates, demographics, and outcomes between white and Afro-Caribbean Americans. Comparative studies of ethnicity in patients undergoing TKAs have been mostly in American populations with an underrepresentation of Asian groups. It is unclear whether these disparities exist in Chinese, Malays, and Indians. We ...
Wang Ziyan Z Molecular Immunology and Pharmacology Group, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, PR - - 2013
Hepatocellular carcinoma (HCC) is a devastating consequence of chronic inflammatory liver diseases. The goal of this study was to investigate whether Toll-like receptor 4 (TLR4) activity contributes to HCC initiation and progression in mice. A mouse model of diethylnitrosamine (DEN)-induced HCC was generated with wild-type and TLR4 mutant mice, and ...
Allen Anne Marie - - 2013
Cholesterol trafficking from the outer to the cholesterol-poor inner mitochondrial membrane requires energized, polarized and actively respiring mitochondria, mediated by a highly regulated multimeric (140-200 kDa) protein complex comprising StAR (steroidogenic acute regulatory protein), mitochondrial TSPO (translocator protein), VDAC (voltage-dependent anion channel), ANT (adenine nucleotide transporter) and associated regulatory proteins. Mitochondrial ...
Bechmann Lars P - - 2013
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in industrialized countries and may proceed to steatohepatitis (NASH). Apoptosis and free fatty acid (FFA)-induced lipotoxicity are important features of NASH pathogenesis. We have shown a hepatoprotective effect of adiponectin in steatotic livers of hepatitis C virus (HCV) patients ...
Swiderska-Syn Marzena M Division of Gastroenterology and Hepatology, Department of Medicine, Duke University Medical Center, Durham, NC, - - 2013
It is unclear why the histology of pediatric and adult nonalcoholic fatty liver disease (NAFLD) sometimes differs. In adults, severity of portal inflammation and fibrosis correlate with Hedgehog pathway activity. Hedgehog (Hh) signaling regulates organogenesis, but is silent in adult livers until injury reinduces Hh ligand production. During adolescence, liver ...
Finn Richard S RS Department of Medicine, Division of Hematology/Oncology, Geffen School of Medicine at UCLA, Los Angeles, CA, USA. - - 2013
Hepatocellular carcinoma (HCC) is the fifth most common malignancy and is the third leading cause of cancer death worldwide. Recently, the multitargeted kinase inhibitor sorafenib was shown to be the first systemic agent to improve survival in advanced HCC. Unlike other malignancies such as breast cancer, in which molecular subtypes ...
Bijland Silvia S Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, - - 2013
AMPK (AMP-activated protein kinase) is a key regulator of cellular and whole-body energy balance. AMPK phosphorylates and regulates many proteins concerned with nutrient metabolism, largely acting to suppress anabolic ATP-consuming pathways while stimulating catabolic ATP-generating pathways. This has led to considerable interest in AMPK as a therapeutic target for the ...
Hale L J LJ Academic and Children's Renal Unit, University of Bristol, Learning and Research, Southmead Hospital, Bristol, BS10 5NB, - - 2013
Podocytes are crucial for preventing the passage of albumin into the urine and, when lost, are associated with the development of albuminuria, renal failure and cardiovascular disease. Podocytes have limited capacity to regenerate, therefore pro-survival mechanisms are critically important. Insulin-like growth factor-II (IGF-II) is a potent survival and growth factor; ...
Levin Frances R FR New York State Psychiatric Institute, Division of Substance Abuse, 1051 Riverside Drive, New York, NY 10032, USA. - - 2013
To evaluate whether venlafaxine-extended release (VEN-XR) is an effective treatment for cannabis dependence with concurrent depressive disorders. This was a randomized, 12-week, double-blind, placebo-controlled trial of out-patients (n = 103) with DSM-IV cannabis dependence and major depressive disorder or dysthymia. Participants received up to 375 mg VEN-XR on a fixed-flexible schedule or placebo. ...
Gao Lili L Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, - - 2013
Nogo-B, also known as reticulon 4B, promotes liver fibrosis and cirrhosis by facilitating the transforming growth factor β (TGF-β) signaling pathway in activated hepatic stellate cells. The aim of this study was to determine the role of Nogo-B in hepatocyte proliferation and liver regeneration. Partial hepatectomy (PHx, 70% resection) was ...
Thein Hla-Hla HH Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Ontario Institute for Cancer Research/Cancer Care Ontario, Toronto, Ontario, - - 2013
Although the burden of hepatocellular carcinoma (HCC) is an escalating public health problem, it has not been rigorously estimated within a Canadian context. We conducted a population-based study using Ontario Cancer Registry linked administrative data. The mean net costs of care due to HCC were estimated using a phase of ...
Liang Yingjian Y Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Department of General Surgery, the First Affiliated Hospital of Harbin Medical University, Harbin, - - 2013
The increasing incidence of hepatocellular carcinoma (HCC) is of great concern not only in the United States but throughout the world. Although sorafenib, a multikinase inhibitor with antiangiogenic and antiproliferative effects, currently sets the new standard for advanced HCC, tumor response rates are usually quite low. An understanding of the ...
Coulon Stephanie S Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium. - - 2013
The pathophysiology of nonalcoholic steatohepatitis (NASH) should be approached as a multifactorial process. In several stages of NASH, a link between disease progression and hepatic microvasculature changes can be made. In this study we investigated the role of angiogenesis in two mouse models for NASH, and the effect of a ...
Chong Rachel S - - 2013
To assess the relationship between intraocular pressure (IOP) and anterior chamber angle (ACA) configuration as assessed by gonioscopy and anterior segment optical coherence tomography (AS-OCT). A total of 2045 subjects aged 50 years and older, were recruited from a community clinic and underwent AS-OCT, Goldmann applanation tonometry, and gonioscopy. A ...
Taylor Avril A School of Social Sciences, University of the West of Scotland, Paisley, Scotland. - - 2013
To estimate hepatitis C virus (HCV) incidence and HCV risk among Scottish prisoners. National sero-behavioural survey; dried blood spots were collected in order to identify recent HCV infections (i.e. HCV antibody-negative and HCV polymerase chain reaction (PCR)-positive). All 14 closed prisons in Scotland. A total of 5187 prisoners responded to ...
da Silva Alexandre A AA Department of Physiology and Biophysics, Center of Excellence in Cardiovascular-Renal Research, The University of Mississippi Medical Center, Jackson, Mississippi, USA. - - 2013
Obesity is a major worldwide health problem. Excess weight gain is the most significant preventable cause of increased blood pressure (BP) in patients with essential hypertension and increases the risk for cardiovascular and renal diseases. Our goal is to review the mechanisms that link obesity with hypertension, with special emphasis ...
Tamez Hector H Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, - - 2013
Both vitamin D deficiency and hypertension are highly prevalent. It is unclear whether vitamin D modulates blood pressure and therefore whether vitamin D testing and therapy should become part of routine hypertension prevention and management. This article provides an overview of the data, with special emphasis on the work published ...
Reusch Jane E B JE Denver VA Medical Center, Clermont Street, Denver, CO 80220, USA. - - 2013
Limitations in physical fitness, a consistent finding in individuals with both type I and type 2 diabetes mellitus, correlate strongly with cardiovascular and all-cause mortality. These limitations may significantly contribute to the persistent excess cardiovascular mortality affecting this group. Exercise impairments in VO2 peak and VO2 kinetics manifest early on ...
Song De-Gang DG Ovarian Cancer Research Center, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19104, - - 2013
NKG2D ligands (NKG2DLs) are widely expressed on ovarian cancers to various degrees, making them attractive targets for immunotherapy. Here, we applied a chimeric antigen receptor (CAR) approach for the targeting of NKG2DLs expressed on human ovarian cancer cells and evaluated the impact of pharmacological upregulation of NKG2DLs on immune recognition. ...
Ohkawa Shingo S Programs for Applied Biomedicine, Division of Clinical Medical Science, Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. - - 2013
Skeletal muscle injuries often leave lasting functional damage or pain. Muscle injuries are routinely treated conservatively, but the most effective treatment to promote the repair of injured muscles has not yet been established. Our previous report demonstrated that human peripheral blood-derived CD133(+) cell transplantation to rat skeletal muscle injury models ...
Willard James J JJ Department of Materials Science and Engineering, The Ohio State University, Columbus, Ohio 43210, - - 2013
Tissue engineering scaffolds are commonly formed using proteins extracted from animal tissues, such as bovine hide. Risks associated with the use of these materials include hypersensitivity and pathogenic contamination. Human-derived proteins lower the risk of hypersensitivity, but possess the risk of disease transmission. Methods engineering recombinant human proteins using plant ...
Kurinna Svitlana S Department of Biochemistry and Molecular BiologyThe University of Texas MD Anderson Cancer Center, Houston, TX, - - 2013
Functions of p53 during mitosis reportedly include prevention of polyploidy and transmission of aberrant chromosomes. However, whether p53 plays these roles during genomic surveillance in vivo and, if so, whether this is done via direct or indirect means remain unknown. The ability of normal, mature hepatocytes to respond to stimuli, ...
Lee Jennifer W JW Division of Newborn Medicine, Floating Hospital for Children at Tufts Medical Center, Boston, MA 02111, USA . - - 2013
To explore (1) whether extremely low gestational age newborns exposed to inflammation-associated pregnancy disorders differ in retinopathy of prematurity (ROP) risk from infants exposed to placenta dysfunction-associated disorders, and (2) whether ROP risk associated with postnatal hyperoxemia and bacteremia differs among infants exposed to these disorders. Pregnancy disorders resulting in ...
Cammà Calogero - - 2013
The purpose was to assess the cost-effectiveness of sorafenib in the treatment of hepatocellular carcinoma (HCC) patients incorporating current prices and the results of the recent published field practice SOraFenib Italian Assessment (SOFIA) study. We created a Markov Decision Model to evaluate, in a hypothetical cohort of Caucasian male patients, ...
Blainey Paul C PC Broad Institute of Harvard and MIT, Cambridge, MA, USA. - - 2013
Interest in the expanding catalog of uncultivated microorganisms, increasing recognition of heterogeneity among seemingly similar cells, and technological advances in whole-genome amplification and single-cell manipulation are driving considerable progress in single-cell genomics. Here, the spectrum of applications for single-cell genomics, key advances in the development of the field, and emerging ...
Baik Song S MRC Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham, Edgbaston, Birmingham, - - 2013
In the adult thymus, the development of self-tolerant thymocytes requires interactions with thymic epithelial cells (TECs). Although both cortical and medullary TECs (cTECs/mTECs) are known to arise from common bipotent TEC progenitors, the phenotype of these progenitors and the timing of the emergence of these distinct lineages remain unclear. Here, ...
Richards Laura A - - 2013
Environmentally relevant contaminants fluoride, chloride, nitrate, and nitrite face Arrhenius energy barriers during transport through nanofiltration (NF) membranes. The energy barriers were quantified using crossflow filtration experiments and were in the range of 7-17 kcal·mol(-1), according to ion type and membrane type (Filmtec NF90 and NF270). Fluoride faced a comparatively ...
Ramasubbu Chitra - - 2013
The last 30 years have witnessed the growth of spinal cord stimulation as a treatment modality for an increasing number of chronic pain conditions. In spite of this growth, one of the greatest criticisms is the lack of concrete evidence for the mechanism of action. With the ever increasing enlightenment with ...
Stephens Joanna C - - 2013
The maxillary sinus may be involved in a wide variety of disorders. Many of these share common presenting symptoms but some have unique features. This article reviews some of the recent publications in this area. The majority of isolated maxillary sinus disease has been previously described. Some recent data on ...
van der Hoeven-Hangoor E - - 2013
Reducing litter moisture is an effective measure to reduce the incidence of footpad dermatitis. Dietary mineral levels affect intestinal conditions with regard to osmolarity and water reabsorption. Magnesium is often used as a laxative, preventing reabsorption of water from the digesta, and as a consequence, more moisture in the excreta. ...
Thomson Ruth M - - 2013
This review examines the role of platelets in ischemic stroke, platelet activation mechanisms, aspirin's rise as an antithrombotic agent, clopidogrel's appearance on the stage, a possible role for combination therapy, antiplatelet resistance, practical considerations, and future directions. Reviewed in this chapter are issues central to optimal antiplatelet therapy: efficacy, safety, ...
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