Search Results
Results 201 - 250 of 3245
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Parker Brittany C - - 2013
Fusion genes are chromosomal aberrations that are found in many cancers and can be used as prognostic markers and drug targets in clinical practice. Fusions can lead to production of oncogenic fusion proteins or to enhanced expression of oncogenes. Several recent studies have reported that some fusion genes can escape ...
Nakajima Naomi - - 2013
OBJECTIVE: Stereotactic ablative radiotherapy (SABR), also known as stereotactic body radiotherapy (SBRT), is now a standard treatment option for patients with stage I non-small cell lung cancer or oligometastatic lung tumor who are medically inoperable or medically operable but refuse surgery. When mass-like consolidation is observed on follow-up CT after ...
Eide M G - - 2013
BACKGROUND: Accumulating evidence suggests that fetal growth restriction may increase risk of later schizophrenia but this issue has not been addressed directly in previous studies. We examined whether the degree of fetal growth restriction was linearly related to risk of schizophrenia, and also whether maternal pre-eclampsia, associated with both placental ...
Legrand Sara-Ann - - 2013
Our objective was to determine the presence of psychoactive substances in blood of drivers killed in road crashes in four European countries. Data from 1118 drivers of car and vans, killed between 2006 and 2009, were collected in Finland, Norway, Portugal and Sweden. The prevalence of any psychoactive substance ranged ...
Jedrychowski Wieslaw A - - 2013
In a birth cohort study, we have assessed the dose-response relationship between individual measurements of prenatal airborne polycyclic aromatic hydrocarbon (PAH) exposure and specific PAH-DNA adducts in cord blood adjusted for maternal blood adducts and season of birth. The study uses data from an earlier established birth cohort of children ...
Tikkanen Soile - - 2013
Abstract This study examined a client's therapeutic progress within one session of an 18-session child neurological assessment. The analysis focused on a parent-psychologist dialogue in one session of the assessment process. Dialogical sequence analysis (DSA; Leiman, 2004, 2012) was used as a micro-analytic method to examine the developing discourse. The analysis ...
Kanda Eiichiro - - 2013
ABSTRACT: BACKGROUND: Metabolic acidosis leads to chronic kidney disease (CKD) progression. The guidelines recommend a lower limit of serum bicarbonate level, but no upper limit. For serum bicarbonate level to be clinically useful as a therapeutic target marker, it is necessary to investigate the target serum bicarbonate level within the ...
Krausz Reinhardt Michael - - 2013
OBJECTIVE: To determine the standardized rates of mental disorder, health service use and barriers to care in a representatively diverse sample of homeless adults in three different sized urban centers in British Columbia, Canada. METHOD: Five hundred homeless adults from Vancouver, Victoria and Prince George were recruited. The MINI-International Neuropsychiatric ...
Quinn Jennifer J JJ Department of Psychology, Miami University, 90 N. Patterson Avenue, Oxford, OH 45056, USA. - - 2013
The mouse has emerged as an advantageous species for studying the brain circuitry that underlies complex behavior and for modeling neuropsychiatric disease. The transition from flexible, goal-directed actions to inflexible, habitual responses is argued to be a valid and reliable behavioral model for studying a core aspect of corticostriatal systems ...
Meins Elizabeth - - 2013
Relations between mothers' tendency to comment appropriately on their 8-month-olds' internal states (mind-mindedness) and children's behavioral difficulties (Strengths and Difficulties Questionnaire) at ages 44 and 61 months were investigated in a socially diverse sample (N = 171, 88 boys). Controlling for maternal depressive symptoms, perceived social support, sensitivity, child language ability, and child ...
Watanabe Jun - - 2013
MNSFβ is a ubiquitously expressed member of the ubiquitin-like family that has been involved in various biological functions. Previous studies have demonstrated that MNSFβ covalently binds to intracellular pro-apoptotic protein Bcl-G and regulates the ERK-MAPK cascade in mouse macrophage cell line, Raw264.7. In this study, we demonstrate that MNSFβ promotes ...
Al-Kasspooles Mazin F - - 2013
The present studies were carried out to examine the efficacy of a nanoparticulate formulation of SN38, the potent topoisomerase I inhibitor and active metabolite of irinotecan. Metabolism of irinotecan to SN38 is inefficient and subject to considerable patient-to-patient variability. One approach to more controlled administration of the anticancer agent is ...
Poggio Claudio - - 2013
AIM: The purposes of this study were to evaluate the effect of surface pretreatment with phosphoric acid on the enamel bond strength of four-one-step self-etch adhesives with different pH values. MATERIAL AND METHODS: One hundred bovine permanent mandibular incisors were used. The materials used in this study included four-one-step self-etch ...
Dalton Mark Anthony - - 2013
Abstract Aim: To explore perceptions of junior doctors, nurses and advanced nurse practitioners (ANP) in relation to the role of the ANP. Method: A qualitative cross-sectional design was used, embedded in an interpretative philosophy. A non-probability sample of six junior doctors, six ward nurses and six ANPs took part in ...
Lee Kang Hong - - 2013
BACKGROUND: We assessed the short- and long-term outcomes of intracorporeal ileocolic anastomosis (IA) in laparoscopic right hemicolectomy for colon cancer compared with extracorporeal anastomosis (EA). METHODS: A retrospective chart review of 86 consecutive patients who underwent laparoscopic right hemicolectomy for colon cancer from March 2005 to June 2010 was performed. ...
Wang Xiaosheng - - 2013
The emergence of a huge volume of "omics" data enables a computational approach to the investigation of the biology of cancer. The cancer informatics approach is a useful supplement to the traditional experimental approach. This article reviewed several reports that used a bioinformatics approach to analyze the associations among aging, ...
Mudge Stephen R - - 2013
Isomaltulose (IM) is a natural isomer of sucrose. It is widely approved as a food with properties including slower digestion, lower glycaemic index and low cariogenicity, which can benefit consumers. Availability is currently limited by the cost of fermentative conversion from sucrose. Transgenic sugarcane plants with developmentally-controlled expression of a ...
Souza Maria A - - 2013
Advances in the glycobiology and immunology fields have provided many insights into the role of carbohydrate-protein interactions in the immune system. We aim to present a comprehensive review of the effects that some plant lectins exert as immunomodulatory agents, showing that they are able to positively modify the immune response ...
Ding Wei-Feng - - 2013
A new cell line named RIRI-PaDe, developed from the neonate larvae of Papilio demoleus Linnaeus, was established in modified Grace's medium supplemented with 20% fetal bovine serum. The cell line was incubated at 28°C and consisted of attached round and short spindle-like cells. The population doubling time was 55 h. The ...
Zhou Hui - - 2013
Jatrorrhizine, one of the protoberberine alkaloids derived from the plant Coptis chinensis, is expected to be developed as a new gastric prokinetic drug, but its metabolic characteristics in humans remain unknown. This study characterized the phase I and phase II metabolites, metabolic kinetics, and cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) ...
Gaillard Jean-Michel - - 2013
How populations respond to climate change depends on the interplay between life history, resource availability, and the intensity of the change. Roe deer are income breeders, with high levels of allocation to reproduction, and are hence strongly constrained by the availability of high quality resources during spring. We investigated how ...
Schaeffner Bjoern C - - 2013
A new genus of trypanorhynch cestodes, Pristiorhynchus n. g. (Otobothrioidea: Otobothriidae), is described from two species of modern sawfishes (Pristidae) from off northern Australia. Pristiorhynchus palmi n. g., n. sp. is characterised by an acraspedote scolex with two bothria, paired bothrial pits on the posterior margins of each bothrium, the ...
Roy Souvik - - 2013
In the present study, we aimed to investigate the protective effect of ferulic acid at different doses (50 mg/kg alternative day and 50 mg/kg daily) on diabetic rats and to explore the interrelationship between oxidative stress and cytokines correlates with apoptotic events in pancreatic tissue. Male Wistar rats were rendered diabetic by ...
Gokhin David S - - 2013
Correct specification of myofilament length is essential for efficient skeletal muscle contraction. The length of thin actin filaments can be explained by a novel 'two-segment' model, wherein the thin filaments consist of two concatenated segments, which are of either constant or variable length. This is in contrast to the classic ...
Fernando A B P - - 2013
RATIONALE: Safety signals providing relief are hypothesised to possess conditioned reinforcing properties, supporting the acquisition of a new response (AnR) as seen with appetitive stimuli. Such responding should also be sensitive to the rate-increasing effects of d-amphetamine and to the anxiolytics 8-OH-DPAT and diazepam. OBJECTIVES: This study tests whether safety ...
Becker Felicitas - - 2013
Recent studies reported mutations in the gene encoding the proline-rich transmembrane protein 2 (PRRT2) to be causative for paroxysmal kinesigenic dyskinesia (PKD), PKD combined with infantile seizures (ICCA), and benign familial infantile seizures (BFIS). PRRT2 is a presynaptic protein which seems to play an important role in exocytosis and neurotransmitter ...
Hyder Fahmeed F Magnetic Resonance Research Center, Yale University, New Haven, Connecticut 06520, USA. - - 2013
Rodent (13)C magnetic resonance spectroscopy studies show that glutamatergic signaling requires high oxidative energy in the awake resting state and allowed calibration of functional magnetic resonance imaging (fMRI) signal in terms of energy relative to the resting energy. Here, we derived energy used for glutamatergic signaling in the awake resting ...
Hayes Lesley - - 2013
The Florence Nightingale Foundation Trust awarded me a travel scholarship in 2012. This enabled me to undertake visits to link with a range of health and social care professionals, services and universities in Spain and America (Houston and Louisville), with the aim of exploring the nature and management of self-neglect ...
Drewniak L - - 2013
It is well known that microorganisms can dissolve different minerals and use them as sources of nutrients and energy. The majority of rock minerals are rich in vital elements (e.g., P, Fe, S, Mg and Mo), but some may also contain toxic metals or metalloids, like arsenic. The toxicity of ...
Hanlidou Effie - - 2013
Thymus leucospermus Hartvig is a Greek endemic species of Section Teucrioides Jalas. The essential oils obtained from five populations growing wild in the National Park of Northern Pindhos (NW Greece) were studied. The oil content ranged between 1.1 and 2.0 mL per 100 g of dry plant weight. The oils were particularly ...
Hashem N M - - 2013
This study was designed to study the effect of short-term supplementation with rumen-protected fat during the late luteal phase on reproduction and metabolism of sheep during breeding season. Seventy-six ewes (Rahmani, Barki and Awassi × Barki) were allocated to two groups considering genotype: the control ewes (C-group) received a maintenance diet, and ...
Ferron Géraldine M - - 2013
To develop a population pharmacokinetic (PK) model for cabazitaxel in patients with advanced solid tumors and examine the influence of demographic and baseline parameters. One hundred and seventy patients who received cabazitaxel (10-30 mg/m(2), 1-h IV infusion) every 7 or 21 days in five Phase I-III studies were analyzed by ...
Arnau Jaume - - 2013
This study analyzes the robustness of the linear mixed model (LMM) with the Kenward-Roger (KR) procedure to violations of normality and sphericity when used in split-plot designs with small sample sizes. Specifically, it explores the independent effect of skewness and kurtosis on KR robustness for the values of skewness and ...
Lambert Carey - - 2013
Bdellovibrio bacteriovorus are predatory bacteria that burrow into prey bacteria and degrade their cell contents, including DNA and RNA, to use for growth. Their genome encodes diverse nucleases, some with potential export sequences. Transcriptomic analysis determined two candidate predicted nuclease genes (bd1244, bd1934) upregulated upon contact with prey; which, we ...
Velmurugan Sathya - - 2013
In the rat hypothalamus, fasting attenuates the expression of oxytocin and this can be reversed by exogenous leptin administration. Here, we studied the effects of systemically administered leptin on the electrical activity of magnocellular neurones in the supraoptic nucleus of urethane-anaesthetized rats. In virgin female rats, systemic leptin significantly excited ...
Herrera Mercedes - - 2013
Tumor epithelial cells within a tumor coexist with a complex microenvironment in which a variety of interactions between its various components determine the behavior of the primary tumors. Cancer-associated fibroblasts (CAFs) and M2 macrophages, characterized by a high expression of different markers, including α-SMA, FSP1 and FAP, or CD163 and ...
Venditti Alessandro - - 2013
Endemic Sideritis italica (MILL.) GREUTER et BURTER (Lamiaceae) occurs mainly in Southern Italy and Sicily and has previously only been studied for the essential oil composition. In this paper, we complete the phytochemical study of a sample of S. italica, previously analysed for its volatile constituents, occurring in the Appennino ...
Petkov Boyan - - 2013
Variations in total ozone column and sun exposures able to cause erythema and damage the DNA molecules were observed by the narrow-band filter radiometer UV-RAD in Bologna, Italy from 2005 to 2010. The ozone columns determined from the UV-RAD measurements were found to be close to those provided by the ...
Dovgopoly Alexander - - 2013
Individuals with autism spectrum disorder (ASD) show atypical patterns of learning and generalization. We explored the possible impacts of autism-related neural abnormalities on perceptual category learning using a neural network model of visual cortical processing. When applied to experiments in which children or adults were trained to classify complex two-dimensional ...
Rayburn Andrew P - - 2013
Although plant spatial patterns strongly influence community-structuring processes, few empirical studies have addressed pattern effects on perennial community dynamics. We tested the effects of community- and neighborhood-scale patterns in experimental semi-arid grassland communities comprising the stronger competitor crested wheatgrass (Agropyron cristatum) and the weaker competitor Snake River wheatgrass (Elymus wawawaiensis). ...
Pulis Eric E - - 2013
Species of the Haploporidae Nicoll, 1914 with elaborate muscularisation of the oral sucker belong in three trematode genera, including three new species and a new genus from the intestine of fishes in Australian waters. Spiritestis Nagaty, 1948 is resurrected and S. herveyensis n. sp. is described from the mullet Moolgarda ...
Sudar Martina - - 2013
Cell disruption process of dry baker's yeast was studied in this work to obtain maximum activity of alcohol dehydrogenase (ADH). Disruption by ultrasonication, glass beads, and combination of these two methods was compared. A 1.8-fold increase of ADH activity can be achieved by combining glass beads with ultrasonication in comparison ...
Foster Paul S - - 2013
Abstract Some evidence exists supporting a relationship between spreading activation in semantic/lexical memory networks and episodic memory. However, the results have been mixed and there have been no investigations examining whether a relationship exists between variability in spreading activation and episodic memory. Hence, we sought to investigate these potential relationships. ...
Levine Stephen Z - - 2013
PURPOSE: The current study aims to examine the potential use of the seven-item Center for Epidemiologic Studies Depression Scale (CES-D) short form (CES-D-SF). METHODS: Data were examined from the National Longitudinal Survey of Youth 1979. Participants responded to the 20-item CES-D (n = 8,858) in 1992, and to the 7-item CES-D-SF in ...
Rees M L - - 2013
Previous studies from our laboratory have shown positive benefits of linoleic acid (LA) feeding for attenuation of rat heart failure (HF). However, another research group concluded LA feeding was detrimental to cardiac function, using the American Institute of Nutrition 76A (AIN) diet as a background diet for the experimental animals ...
Uchida Mitsuo - - 2013
The effects of change of residence on pollinosis symptoms remain unclear. We investigated the effects of geographical change of residence on pollinosis symptoms among university freshmen. All freshmen (n = 2142) entering Shinshu University in 2011 completed self-administered questionnaires. Associations between history of pollinosis and environmental factors were assessed. Subjects were classified ...
Zhao He-Ping - - 2013
We evaluated a strategy for achieving complete reduction of perchlorate (ClO4-) in the presence of much higher concentrations of sulfate (SO42-) and nitrate (NO3-) in a hydrogen-based membrane biofilm reactor (MBfR). Full ClO4- reduction was achieved by using a two-stage MBfR with controlled NO3- surface loadings to each stage. With ...
Bell Reginald C W - - 2013
BACKGROUND: Hiatal repair failure is the nemesis of laparoscopic paraesophageal hernia repair as well as the major cause of failure of primary fundoplication and reoperation on the hiatus. Biologic prosthetics offer the promise of reinforcing the repair without risks associated with permanent prosthetics. DESIGN: Retrospective evaluation of safety and relative ...
Zheleznyakova Galina Y GY Faculty of Biology and Soil Science, Saint-Petersburg State University, Saint-Petersburg, Russia. - - 2013
Spinal muscular atrophy (SMA) is a monogenic disorder that is subdivided into four different types and caused by survival motor neuron gene 1 (SMN1) deletion. Discordant cases of SMA suggest that there exist additional severity modifying factors, apart from the SMN2 gene copy number. Here we performed the first genome-wide ...
Yu Yang - - 2013
Human glutathione transferase zeta 1c-1c (hGSTZ1c-1c) is one of the glutathione transferase isoenzymes and considered to be a protein scaffold to imitate glutathione peroxidase (GPX) owing to the natural binding site of glutathione (GSH). In this report, several residues near GSH were mutated to selenocysteine (Sec) or cysteine (Cys) residues ...
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