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Booij J W - - 2013
AIM: To compare dentoskeletal and soft tissue treatment effects of two alternative Class II division 1 treatment modalities (maxillary first permanent molar extraction versus Herbst appliance). METHODS: One-hundred-fifty-four Class II division 1 patients that had either been treated with extractions of the upper first molars and a lightwire multibracket (MB) appliance (n = 79; 38 girls, 41 boys) ...
Castaneda Julie T JT Division of Pulmonary and Critical Care Medicine, Department of Medicine, CHS 37-131, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1690, - - 2013
mRNA encoding for the CB(2) cannabinoid receptor is expressed by many subsets of human peripheral blood leukocytes (PBL), but little is known about the resulting protein expression and function. Employing clones from the A549 and 293T cell lines that were constructed to express both full-length human CB(2) and GFP, we ...
Karlo Christoph A CA Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue. Radiology Academic Offices, Room C278, New York, NY 10065, USA. - - 2013
To assess qualitative and quantitative chemical shift MRI parameters of renal cortical tumours. A total of 251 consecutive patients underwent 1.5-T MRI before nephrectomy. Two readers (R1, R2) independently evaluated all tumours visually for a decrease in signal intensity (SI) on opposed- compared with in-phase chemical shift images. In addition, ...
Nair Shalini Rajandran SR Department of Biomedical Imaging, Faculty of Medicine, University Malaya Research Imaging Centre, 50603, Kuala Lumpur, - - 2013
To develop a decision tree based on standard magnetic resonance imaging (MRI) and diffusion tensor imaging to differentiate multiple system atrophy (MSA) from Parkinson's disease (PD). 3-T brain MRI and DTI (diffusion tensor imaging) were performed on 26 PD and 13 MSA patients. Regions of interest (ROIs) were the putamen, ...
Dubrulle F F Department of Radiology, CHU Lille, Huriez Hospital, 1 rue Polonovski, 59037 Lille cedex, France. - - 2013
To perform preliminary tests in vitro and with healthy volunteers to determine the 3-T MRI compatibility of a cochlear implant with a non-removable magnet. In the in vitro phase, we tested six implants for temperature changes and internal malfunctioning. We measured the demagnetisation of 65 internal magnets with different tilt ...
Tani Kanae - - 2013
Recently, biological agents have been used for treatment of rheumatoid arthritis (RA), though the standard therapeutic doses vary among the agents utilized. To investigate the mechanisms related to those differences, we theoretically analyzed the target molecular binding occupancies of 4 biological agents: tocilizumab, infliximab, adalimumab, and etanercept. The average binding ...
Peate Ian - - 2013
The Nursing and Midwifery Council (NMC) is the nursing and midwifery regulator for England, Wales, Scotland, Northern Ireland and the Islands. It has a number of key statutory roles-first and foremost to safeguard the health and wellbeing of the public. It is not there to defend nurses and midwives.
Ibrahim Hany M - - 2013
Abstract Objective: The focus of this study was to develop and optimize in situ implant formulation of meloxicam by quality by design (QbD) principle for long-term management of musculoskeletal inflammatory disorders. Methods: The formulation was optimized by Box-Behnken design with polylactide-co-glycolide (PLGA) level (X(1)), N-methyl pyrrolidone level (X(2)) and PLGA ...
Niu Xinli - - 2013
We and others have previously shown that both cimetidine (CIM) and levamisole (LMS) enhance humoral and cellular responses to DNA vaccines via different mechanisms. In this study we investigated the synergistic and additive effects of CIM and LMS on the potency of antigen-specific immunities generated by a DNA vaccine encoding ...
Moad Ahmed Ismail Hassan - - 2013
Autophagy is an evolutionarily conserved lysosomal degradation pathway and plays a critical role in the homeostatic process of recycling proteins and organelles. Functional relationships have been described between apoptosis and autophagy. Perturbations in the apoptotic machinery have been reported to induce autophagic cell deaths. Inhibition of autophagy in cancer cells ...
Sun Andy - - 2013
BACKGROUND: Serum homocysteine level is a biomarker of cardiovascular disease. METHODS: In this study, 399 primary and secondary burning mouth syndrome (BMS) patients without or with hematinic deficiencies were treated with vitamin BC capsules plus none, one, or two deficient hematinics depending on the corresponding deficiency statuses of the patients. ...
Andriessen Anneke - - 2013
Dry skin is common and impacts on wound healing, the severity of other skin disorders, such as inflammatory dermatoses, and on the patient's quality of life. Dry skin may delay wound healing, especially in patients with venous leg ulcers and those with pressure ulcers. The aim of this review was ...
Yoneyama Toshihiro - - 2013
Pancreatic cancer is a devastating disease and early diagnosis and treatment are essential to improve the prognosis. We previously showed that α-fibrinogen containing hydroxylated proline residues at positions 530 and 565 is increased in plasma of pancreatic cancer patients. However, no antibody specific for hydroxylated proline-530 is available. Therefore, the ...
Lev-Tov Hadar - - 2013
ABSTRACT: BACKGROUND: Diabetic foot ulcers (DFUs) represent a significant source of morbidity and an enormous financial burden. Standard care for DFUs involves systemic glucose control, ensuring adequate perfusion, debridement of nonviable tissue, off-loading, control of infection, local wound care and patient education, all administered by a multidisciplinary team. Unfortunately, even ...
Li Xiaoyan - - 2013
One of the main pathological symptoms of early diabetic retinal neuropathy is retina neuronal apoptosis. In the present work we investigated the effects of indoleamine hormone melatonin, a powerful free radical scavenger, on streptozotocin-induced retina neuronal cell apoptosis in high blood glucose rat. After melatonin treatment (10 mg/kg/day), tunel detection was ...
Hur Jinyoung - - 2013
Abstract Oxyresveratrol (2´,3,4´,5-tetrahydroxystilbene) is a naturally occurring ingredient found in mulberries that shows potential as an anti-oxidant, anti-inflammatory, and neuroprotective agent. This study was performed to identify materials similar to oxyresveratrol that may have more effective antioxidant properties. We synthesized a stilbene analog referred to as compound 1 (2´,3,4´,5-tetramethoxystilbene); a ...
Lin Heng - - 2013
Odontoblasts are a type of non-proliferating and terminally differentiated cells that play an important role in the pulpo-dentinal complex. Mouse dental papilla cells (mDPCs), which can differentiate into odontoblast-like cells in vitro, have a limited life span. We combined the traditional strategy of "Cre/LoxP-based reversible immortalization" with a tamoxifen-regulated Cre ...
Campbell H - - 2013
BACKGROUND: Orofacial granulomatosis (OFG) is a chronic granulomatous condition of the mouth, face and lips. Recent work demonstrates a high rate of atopy and silver birch sensitisation from skin prick testing (SPT). Oral allergy syndrome (OAS) is an acute oro-pharyngeal IgE mediated reaction, triggered by foods that cross react with ...
Tingle John - - 2013
The Care Quality Commission (CQC) has published the results of the fourth national accident and emergency survey (CQC, 2012). Overall, 147 acute and specialist NHS trusts with major accident and emergency (A&E) departments in England took part. Almost 46000 patients aged 16 or over who attended A&E during January, February ...
Anandkumar Arachimani - - 2013
Mucins are high molecular weight glycoproteins designed for cellular protection and sensing the external environment. Aberrant glycosylation and altered mucin expression seen in cancers are implicated in mucin dependent refraction to immunosurveilance and immunosuppressive induction around the tumor. Though mucins provide molecular targets for immune system's tumor recognition, their characteristics ...
Nakajima Naomi - - 2013
OBJECTIVE: Stereotactic ablative radiotherapy (SABR), also known as stereotactic body radiotherapy (SBRT), is now a standard treatment option for patients with stage I non-small cell lung cancer or oligometastatic lung tumor who are medically inoperable or medically operable but refuse surgery. When mass-like consolidation is observed on follow-up CT after ...
Eide M G - - 2013
BACKGROUND: Accumulating evidence suggests that fetal growth restriction may increase risk of later schizophrenia but this issue has not been addressed directly in previous studies. We examined whether the degree of fetal growth restriction was linearly related to risk of schizophrenia, and also whether maternal pre-eclampsia, associated with both placental ...
Legrand Sara-Ann - - 2013
Our objective was to determine the presence of psychoactive substances in blood of drivers killed in road crashes in four European countries. Data from 1118 drivers of car and vans, killed between 2006 and 2009, were collected in Finland, Norway, Portugal and Sweden. The prevalence of any psychoactive substance ranged ...
Jedrychowski Wieslaw A - - 2013
In a birth cohort study, we have assessed the dose-response relationship between individual measurements of prenatal airborne polycyclic aromatic hydrocarbon (PAH) exposure and specific PAH-DNA adducts in cord blood adjusted for maternal blood adducts and season of birth. The study uses data from an earlier established birth cohort of children ...
McClimens Alex - - 2013
As community-based care has developed in line with current policy towards integrated care, some hospital placement capacity for student health professionals has been lost as a result of service reorganisation. However, student nurses and allied health professionals need to gain a broad range of experience to prepare them for the ...
Bommana Murali Mohan - - 2013
Abstract Objective: Efficacy of a formulation of a poorly soluble centrally acting drug was evaluated by measuring dopamine responses using in vivo brain microdialysis. Methods: Co-crystals (1:1) of carbamazepine and nicotinamide (CBZ-NCT) were complexed with cyclodextrins (γ-CDs) using supercritical fluid processing. Phase solubility and intrinsic dissolution were studied. Pharmacodynamic studies ...
Son Seok Hyun - - 2013
ABSTRACT: BACKGROUND: The purpose of this study was to identify parameters capable of predicting the deterioration of hepatic function after helical tomotherapy in patients with unresectable locally advanced hepatocellular carcinoma. METHODS: Between March 2006 and February 2012, 72 patients were eligible for this study. All patients received hypofractionated radiotherapy using ...
Ghorayeb Sleiman R - - 2013
Several imaging modalities have traditionally been utilized to assess bone health. However, none of these standards is capable of providing a clear rendition or display of the damaged bone layers caused, for instance, by osteoporosis. This study examines the use of ultrasound for non-invasive monitoring of bone quality in bone ...
Itman Catherine - - 2013
According to the World Health Organization, a fertile man typically has a sperm count of 15 million per milliliter of semen. This spermatogenic capacity is determined by appropriate specification, proliferation, differentiation, and maturation of somatic and germ cells, events that begin during fetal development and continue throughout adulthood. These processes ...
de Lepper Anne M - - 2013
OBJECTIVE: The use of mobile phones can improve and strengthen (preventive) health care in low- and middle-income countries. We aimed to retrospectively assess the response patterns of participants in free SMS health education quizzes in Uganda. METHODS: Study participants were employees of two companies and their community networks. We investigated ...
Sekhwal Manoj Kumar - - 2013
The antiporters, uniporters and symporters are the functional classes of MFS that play major role in ions homeostasis, regulation of pumps and channels, membrane structure, transporters activity in tolerance to abiotic stresses. Major facilitator superfamily (MFS) encodes Na(+)/H(+) antiporter that are considered as being sensors of the molecule transports. A ...
Poulere Eleni - - 2013
PURPOSE: To compare the effects of defocus induced blur and blur adaptation on visual acuity and to evaluate any differences between emmetropes and myopes using letter and Landolt C logMAR charts. METHODS: The sample consisted of 26 volunteers, with a mean age of 27 ± 3 years, comprising 13 emmetropes (spherical equivalent range: ...
Wakabayashi Kaori - - 2013
A new species of parasitic copepod, Choniomyzon inflatus n. sp., is described based on specimens collected from the external egg masses of the smooth fan lobster Ibacus novemdentatus Gibbes captured in the North Pacific Ocean off Ainan, Ehime Prefecture, western Japan. The new species differs from its congeners in having ...
Wright Michelle F - - 2013
Adolescents experience various forms of strain in their lives that may contribute jointly to their engagement in cyber aggression. However, little attention has been given to this idea. To address this gap in the literature, the present longitudinal study examined the moderating influence of peer rejection on the relationship between ...
Yi Wenchao - - 2013
The objective of the study was to further elucidate the potential mechanisms underlying left hemiparalexia induced by a splenium lesion in corpus callosum. A patient KY, who had infarctions in the splenium and the left ventral medial occipitotemporal area, was examined with neuropsychological tests and fMRI. KY presented left hemiparalexia ...
Serrano C - - 2013
Helicobacter pylori induces less gastric inflammation in children than adults. Here we investigated whether this reduced inflammation involves dysregulated T helper type 17 (Th17) responses. H. pylori-infected children and adults in Santiago, Chile had similar levels of H. pylori colonization, proportions of bacteria containing cagA and s1/s2 vacA markers of ...
Rowson Steven - - 2013
Recent research has suggested possible long term effects due to repetitive concussions, highlighting the importance of developing methods to accurately quantify concussion risk. This study introduces a new injury metric, the combined probability of concussion, which computes the overall risk of concussion based on the peak linear and rotational accelerations ...
Yang Qing - - 2013
Coronary artery disease is the most common type of heart disease and a leading cause of morbidity and mortality all over the world. Acute coronary syndrome (ACS) is the most serious form of coronary artery disease. Recently, many studies indicated that genetic susceptibility may play a vital role in the ...
Kassler Kristin - - 2013
The interaction of the HIV-1 fusion protein gp120 with its cellular receptor CD4 represents a crucial step of the viral infection process, thus rendering gp120 a promising target for the intervention with anti-HIV drugs. Naturally occurring mutations of gp120, however, can decrease its affinity for anti-infective ligands like therapeutic antibodies ...
Billington Tracey - - 2013
Tracey Billington is studying part-time for an MSc Health and Social Care at Northumbria University. She qualified as a mental health nurse in January 2012 and is currently employed as a prison substance misuse nurse. Tracey reflects on how using a self-development diary has helped her to develop her self-awareness ...
van de Vijver Steven - - 2013
Background. An increasing burden of cardiovascular disease (CVD) is occurring in low- and middle-income countries (LMICs) as a result of urbanisation and globalisation. Low rates of awareness and treatment of risk factors worsen the prognosis in these settings. Prevention of CVD is proven to be cost effective and should be ...
Ren Xing-Feng - - 2013
We have developed a series of azadipeptide nitriles with different P3 groups. A triaryl meta-phenyl derivative, compound , was not only a potent inhibitor for cathepsin K (K(i) = 0.0031 nM), but also highly selective over both cathepsins B and S (∼1000-fold). A protein-ligand docking study performed on the series ...
Liljavirta J - - 2013
Due to a limited range of immunoglobulin (Ig) genes, cattle and several other domestic animals rely on postrecombinatorial amplification of the primary repertoire. We report that activation-induced cytidine deaminase (AID) is strongly expressed in the fetal bovine ileal Peyer's patch and spleen but not in fetal bone marrow. The numbers ...
Yapijakis Christos - - 2013
The incidence of basal cell carcinoma (BCC) is significantly reduced in individuals treated with inhibitors of angiotensin I-converting enzyme (ACE) that produces angiotensin II. The objective of this study was to investigate the possible association of a functional polymorphism in the ACE gene, which affects its transcription, with risk for ...
Byun Seung Ok - - 2013
FOXO3 is a member of the FOXO (forkhead box class O) transcription factor family and has roles in cell cycle control, apoptosis, neural and hematopoietic cell differentiation and DNA repair among other functions. Several human studies provide evidence for an association between aging, longevity and variation in FOXO3. Recently variation ...
Baca Emrah - - 2013
Abstract Objective. To determine the effects of various implant retained and/or supported prostheses on number of occlusal contacts (NOC), occlusal contact area (OCA)and maximum bite force (BF). Patients and methods: In total, 56 patients were included in the study; five test groups and two control groups. The patients in the ...
Bai Ying-Nan - - 2013
Gibberellic acid stimulated transcriptional protein from Gymnadenia conopsea (GcGAST) is a novel member of GA-induced cysteine-rich protein family, which shared 12 highly conserved cysteine residues with other members in C-terminal domain. In the present paper, the recombinant plasmid, as well as two mutants Serine-Proline-Cysteine (SPC) and Cysteine-Proline-Serine (CPS), were constructed ...
Pérez-Vives Cari - - 2013
PURPOSE: To compare the optical and visual quality of a simulated Toric Implantable Collamer Lens (TICL) and a bioptics technique to treat high myopic astigmatism. METHODS: An adaptive optics visual simulator was used to simulate the vision after TICL implantation and a bioptics procedure from the wavefront aberration pattern for ...
Wang Ya - - 2013
An alginate lyase-producing bacterial strain, Vibrio sp. QY105, was isolated from sea mud of Qingdao. It secreted 90 % of total enzyme activity within the first 20 h of fermentation. An alginate lyase, AlyV5, with an apparent MW of 37 kDa and a specific activity of 2152 U/mg was purified from the culture supernatant. ...
Ishikawa Akira - - 2013
The design of the interplay between light and nanomaterials by the effect of localized-surface-plasmon resonance in metallic nanostructures is a fascinating subject, and recently, a lot of research has been carried out from both fundamental and applicational points of view. In this paper, we demonstrate the theories for describing the ...
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