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Results 701 - 750 of 3245
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Fontaine Jean-Xavier - - 2013
Following the discovery that in Arabidopsis, a third isoenzyme of NADH-dependent glutamate dehydrogenase (GDH) is expressed in the mitochondria of the root companion cells, we have re-examined the GDH isoenzyme composition. By analyzing the NADH-GDH isoenzyme composition of single, double and triple mutants deficient in the expression of the three ...
Hörmann K - - 2013
Objective: Review of the literature on the role of surgery in the management of head and neck cancer in the era of organ preservation. Method: Literature search based on the essential practice guidelines set out by the US National Comprehensive Cancer Network. Results: Despite the increasing popularity of non-surgical treatment ...
El-Sisi Alaa El-Din E - - 2013
Ifosfamide (IFO) is a highly effective chemotherapeutic agent for treating a variety of pediatric solid tumors. However, its use is limited due to its serious side effect on kidneys. The side-chain oxidation of IFO in renal tubular cells produces a reactive toxic metabolite that is believed to be responsible for ...
Rohrmüller M - - 2013
Based on the equilibrium geometries of [Cu(2) (dbdmed)(2) O(2) ](2+) and [Cu(2) (en)(2) O(2) ](2+) obtained within density-functional theory, we investigate their molecular electronic structure and optical response. Thereby results from occupation-constrained as well as time-dependent DFT (ΔSCF and TDDFT) are compared with Green's function-based approaches within many-body perturbation theory ...
Jansen Daniel Joseph - - 2013
An eight step, asymmetric synthesis of a dimeric thiaspirane nuphar alkaloid from 3-methyl-2-cyclopentenone is reported. The brevity of the route relies on a useful procedure for tandem reductive allylation of cyclopentenones, as well as the minimization of redox manipulations and other functional group interconversions. The distribution of products that arise ...
Hanning J E JE Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, - - 2013
When designing therapeutic short-interfering RNAs (siRNAs), off-target effects (OTEs) are usually predicted by computational quantification of messenger RNAs (mRNAs) that contain matches to the siRNA seed sequence in their 3' UTRs. It is assumed that the higher the number of predicted transcriptional OTEs, the greater the size of the actual ...
Thompson Jennifer L - - 2013
OBJECTIVE:To review and summarize data on carfilzomib, which was approved by the Food and Drug Administration (FDA) in July 2012 for the treatment of patients with relapsed and refractory multiple myeloma (MM) who received prior bortezomib and thalidomide or lenalidomide.DATA SOURCES:A literature search through PubMed was conducted through October 2012 ...
Yang Ganglong - - 2013
The interaction of glycan-binding proteins (GBPs) and glycans plays a significant biological role that range from cell-cell recognition to cell trafficking, and glycoprotein targeting. The anomalies of GBPs related to the types and/or quantities were not clearly known in cancer incidence. It is imperative to identify and annotate the GBPs ...
Tully Phillip J - - 2013
Generalized anxiety disorder prevalence and comorbidity with depression in coronary heart disease patients remain unquantified. Systematic searching of Medline, Embase, SCOPUS and PsycINFO databases revealed 1025 unique citations. Aggregate generalized anxiety disorder prevalence (12 studies, N = 3485) was 10.94 per cent (95% confidence interval: 7.8-13.99) and 13.52 per cent ...
Radak Djordje - - 2013
Before the routine use of computed tomography (CT) angiography, decisions for carotid artery treatment were mostly based on ultrasound findings and conventional angiography. Implementation and increasing use of CT angiography provided better visualization of the carotid and vertebrobasilar arteries system leading to an unexpected more frequent detection of unruptured intracranial ...
Samuel Tal Y - - 2013
AIM: To determine the normal SpO(2) in healthy term newborns at mild-altitude (MA, 780 meters) compared to sea level (SL), within the context of universal screening for critical congenital heart disease (CCHD) METHODS: we studied 199 (119 at MA and 80 at SL) consecutively born healthy newborns. SpO(2) recordings were ...
Lohar Sisir - - 2013
Condensation of salicylaldehyde and 4-aminoantipyrine has yielded a new fluorescent probe (APSAL) capable to detect intracellular arsenate at micromolar level for the first time. The structure of the probe has been established by different spectroscopic techniques and confirmed from X-ray crystallography. Common anions viz. F-, Cl-, Br-, I-, N3-, NCO-, ...
Lanas Angel - - 2013
Abstract Objective. To assess clinical outcomes in patients treated with proton pump inhibitors (PPIs) after endoscopic hemostasis in routine clinical care, and to compare these outcomes to those seen in a randomized controlled trial (RCT) of i.v. esomeprazole. Materials and methods. Patients with peptic ulcer bleeding and endoscopic stigmata of ...
Przybyszewska Justyna - - 2013
INTRODUCTION The diagnosis of iron deficiency anemia in the context of the anemia of chronic disease in the elderly is often difficult due to the existence of many disorders. Recent studies show that the indication of hepcidin (in conjunction with existing diagnostic methods) can probably help in the differential diagnosis ...
Song Joseph Bowen - - 2013
Introduction: Port site metastasis (PSM) is a rare complication of laparoscopic intervention in urologic malignancies. Of the greater than 50 reported cases of PSM in the urologic oncology literature, only nine have occurred after surgery for renal cell carcinoma (RCC). Herein, we report a tenth instance of RCC metastasis, in ...
Sinelshchikova Anna A - - 2013
Copper(II) 5,15-bis(diethoxyphosphoryl)-10,20-diphenylporphyrin was obtained and characterized by means of cyclic voltammetry, electron paramagnetic resonance, Fourier transform infrared, and UV-visible spectroscopy. Three crystalline forms were grown and studied by means of X-ray diffraction methods (single crystal and powder). The highly electron-withdrawing effect of phosphoryl groups attached directly to the porphyrin macrocycle ...
Briceño E M - - 2013
BACKGROUND: Facial emotion perception (FEP) is a critical human skill for successful social interaction, and a substantial body of literature suggests that explicit FEP is disrupted in major depressive disorder (MDD). Prior research suggests that weakness in FEP may be an important phenomenon underlying patterns of emotion-processing challenges in MDD ...
Haudecoeur Romain - - 2013
An unprecedented strategy to control the quadruplex- vs duplex-DNA selectivity of a ligand is reported. We designed a compound whose structure can rearrange when it interacts with a G-quadruplex, thereby controlling its affinity. Thus, the first "smart G-quadruplex ligand" is reported, since this ligand experiences a structural change in the ...
Awale Mahendra - - 2013
The MQN-mapplet is a Java application giving access to the structure of small molecules in large databases via color-coded maps of their chemical space. These maps are projections from a 42-dimensional property space defined by 42 integer value descriptors called molecular quantum numbers (MQN), which count different categories of atoms, ...
Freude Thomas - - 2013
ABSTRACT: BACKGROUND: During the last few years, an increasing number of unstable thoracolumbar fractures, especially in elderly patients, has been treated by dorsal instrumentation combined with a balloon kyphoplasty. This combination provides additional stabilization to the anterior spinal column without any need for a second ventral approach. CASE PRESENTATION: We ...
Wentzensen Nicolas N Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852-7234, - - 2013
Researchers developing biomarkers for early detection can determine the potential for clinical benefit at early stages of development. We provide the theoretical background showing the quantitative connection between biomarker levels in cases and controls and clinically meaningful risk measures, as well as a spreadsheet for researchers to use in their ...
Wiersum Andrew D - - 2013
A high-throughput gas adsorption apparatus is presented for the evaluation of adsorbents of interest in gas storage and separation applications. This instrument is capable of measuring complete adsorption isotherms up to 40 bar on six samples in parallel using as little as 60 mg of material. Multiple adsorption cycles can ...
Vlachopoulos Charalambos V - - 2013
BACKGROUND: =0.006).Conclusions-ED is associated with increased risk of CV events and all-cause mortality. RR is higher at younger ages, in intermediate-risk groups, and when a questionnaire is used instead of a single question.
Kim Young-Kyoung - - 2013
3-Hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) catalyzes the rate-limiting step in the mevalonate pathway. To elucidate the functions of HMGR in triterpene biosynthesis, Platycodon grandiflorum was transformed with a construct expressing Panax ginseng HMGR (PgHMGR). We used PCR analysis to select transformed hairy root lines and selected 6 lines for further investigation. ...
Hardimon Michael O - - 2013
Confusions about the place of race in medicine result in part from a failure to recognize the plurality of race concepts. Recognition that the ordinary concept of race is not identical to the racialist concept of race makes it possible to ask whether there might be a legitimate place for ...
Beauregard Eric - - 2013
The aim of this study was to test whether there is a relationship between situational and modus operandi characteristics and criminal mobility during the sexual assault event. Data collected from both police files and semistructured interviews with 72 serial sex offenders who have committed 361 sexual assaults have been used. ...
Zhang Yang - - 2013
Tb(3+), Tm(3+), and Dy(3+)-activated SrY(2)O(4) phosphors have been prepared via Pechini-type sol-gel method. X-Ray diffraction (XRD), field-emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), photoluminescence (PL) and lifetimes, as well as cathodoluminescence (CL) spectra were used to characterize the samples. Under low-voltage electron beam excitation, the Tb(3+)-doped samples show ...
Hsu Hong-Yuan - - 2013
Background. The long-term evolution and outcomes of hepatitis B surface gene mutant (HBSGM) infection in immunized children remain unclear.Methods. Ninety-five HBsAg-positive children with postnatal immunoprophylaxis failure, aged 0.5-18.4 (mean 5.8) years, were prospectively followed for 1-22.8 (mean 8.5) years. Clinical, serologic and virologic features were compared between untreated, HBeAg-positve children carrying HBSGM ...
Avula Bharathi - - 2013
Terminalia species are a rich source of tannins. Many preparations of these species are used in traditional medicine and have many different ethnobotanical applications. A simple UHPLC method was developed for the simultaneous analysis of such hydrolysable tannins and triterpene saponins from the fruit rinds of different species of Terminalia ...
Wang Huan - - 2013
This study demonstrates a potential signaling pathway of CO 2-dependent stimulation in lateral root (LR) formation. Elevated CO 2 increases production of nitric oxide (NO), which subsequently stimulates the generation of cytosolic Ca ( 2+) concentration by activating plasma membrane and/or intracellular Ca ( 2+) -permeable channels. Meanwhile, nitric oxide ...
St-Cœur Patrick-Denis - - 2013
A series of PF-8380 analogs, a recently developed autotaxin inhibitor, was explored. Inhibition of autotaxin by these analogs, as well as by all PF-8380 synthetic intermediates, shows the importance of meta-dichlorobenzyl and benzo[d]oxazol-2(3H)-one fragments. However, analogs 8 and 9, bearing only the benzo[d]oxazol-2(3H)-one moiety, are more cytotoxic on the LN229 ...
Akama Keith T KT Laboratory of Neuroendocrinology, The Rockefeller University, Weill Cornell Medical College, New York, New York 10065, - - 2013
The estrogen 17β-estradiol (E2) modulates dendritic spine plasticity in the cornu ammonis 1 (CA1) region of the hippocampus, and GPR30 (G-protein coupled estrogen receptor 1 (GPER1)) is an estrogen-sensitive G-protein-coupled receptor (GPCR) that is expressed in the mammalian brain and in specific subregions that are responsive to E2, including the ...
Van Houtte Hilde - - 2013
The Arabidopsis trehalose-6-phosphate phosphatase (TPP) gene family arose mainly from whole genome duplication events and consists of 10 genes (TPPA-J). All the members encode active TPP enzymes, possibly regulating the levels of trehalose-6-phosphate, an established signaling metabolite in plants. GUS activity studies revealed tissue-, cell- and stage-specific expression patterns for ...
Parks Joel H - - 2013
Abstract Recent time resolved lifetime measurements studied the quenching of the fluorescence emitted by a dye covalently bound to the desolvated peptide Dye-Pro4-Arg+-Trp. This peptide sequence was chosen for study since intramolecular interactions constrain all large-scale fluctuations except for those of the interacting dye and Trp sidechain. It was shown ...
Wu Yang - - 2013
A uniform Fe3O4 sheath is magnetron sputtered onto aligned carbon nanotube (CNT) scaffolds which are directly drawn from CNT arrays. The Fe3O4-CNT composite electrode, with the size of Fe3O4 confined to 5-7 nm, exhibits a high reversible capacity over 800 mAh g-1 based on the total electrode mass, remarkable capacity ...
Toydemir Toygar - - 2013
The aim of the present study was to assess the influence of curcumin on liver regeneration after partial hepatectomy (PH) in rats. A total of 24 male Sprague Dawley rats were divided into three groups: sham-operated (SH), PH, and PH + curcumin; each group contains eight animals. The rats in ...
Huang Genping - - 2013
DFT/M06 calculations were carried out to better understand the mechanism, regio- and chemoselectivities of our previously discovered formal C-H amination of silyl cyclopropenes by azodicarboxylates (Chem. Commun. 2012, 48, 10990). The results revealed that the initial Alder-ene reaction between the two reactants follows a stepwise mechanism and the subsequent allylic ...
Iacomino Giuseppe - - 2013
Celiac disease is a chronic enteropathy caused by the ingestion of wheat gliadin and other cereal prolamines. The synthetic peptides 31-43 (P31-43) and 31-49 (P31-49) from A-gliadin are considered to be model peptides for studying innate immunity in celiac disease. Our previous study demonstrated that P31-43 and P31-49 are encrypted ...
Eyal Ori - - 2013
AIM: To determine whether non-classical 21-hydroxylase deficiency (NC21OHD) compromises adult height (AH), and to establish the clinical parameters affecting AH in subjects with NC21OHD. METHODS: A multicenter, retrospective review of medical records for clinical and biochemical parameters. The corrected height (CH) standard deviation score (SDS), defined as AH SDS minus ...
Krzymień Janusz - - 2013
INTRODUCTION Lactic acidosis is a relatively rare complication diagnosed in patients with diabetes. The aim of this study was to identify causes of lactic acidosis in this group of patients and to measure the extent of metabolic disturbances based on the available laboratory test results. METHODS 29 diabetic patients diagnosed with " ...
Mitra Joyee - - 2013
Synthesis of two complexes, [NBu(n)(4)][Mo(IV)O(mnt)(S-Tol)(N-N)] (N-N = 2,2'-bipyridine () or 1,10-phenanthroline (); mnt = maleonitriledithiolate; S-Tol = toluenethiol) are reported. These on treatment with H(2)S generate the corresponding [NBu(n)(4)][Mo(IV)O(mnt)(SH)(N-N)] ( and ) complexes bearing the susceptible hydrosulfide coordination. (and ) upon chemical oxidation show EPR spectra with the appearance of ...
Carrara-Nascimento Priscila F PF Departamento de Farmacologia , Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, - - 2013
Increasing evidence shows that excessive alcohol consumption during adolescence increases vulnerability to alcohol use disorders in adulthood. The aim of this study was to examine differences between adolescent and adult C57BL/6J mice in drinking behavior and blood ethanol (EtOH) concentrations (BECs) after chronic EtOH exposure and withdrawal. Male adolescent (PND = 28 ...
Ramos M Luísa - - 2013
Multinuclear ((1)H, (13)C and (71)Ga) magnetic resonance spectroscopy (1D and 2D), DFT calculations and luminescence techniques have been used to study 8-hydroxyquinoline-5-sulfonate (8-HQS) and its complexes with Ga(iii) in aqueous solutions. The study combines the high sensitivity of luminescence techniques and the selectivity of multinuclear NMR spectroscopy with the structural ...
Duffy Laura - - 2013
BACKGROUND AND PURPOSE: The Barthel Index (BI) is a 10-item measure of activities of daily living which is frequently used in clinical practice and as a trial outcome measure in stroke. We sought to describe the reliability (interobserver variability) of standard BI in stroke cohorts using systematic review and meta-analysis ...
Lampre Isabelle - - 2013
The reaction of •OH with Br- has been re-investigated by picosecond pulse radiolysis combined with streak camera absorption detection and the obtained spectro-kinetics data have been globally analyzed using Bayesian data analysis. For the first time, the absorption spectrum of the intermediate species BrOH•- has been determined. This species absorbs ...
Wang Xin - - 2013
In this study, hemolysis, Western blot, and real-time RT-PCR assays were performed to evaluate silibinin's activity against S. aureus α-toxin secretion. In addition, live/dead cell staining and lactate dehydrogenase activity assays were introduced to examine the influence of silibinin on α-toxin-induced cell injury in human alveolar epithelial cells. Furthermore, we ...
Troop Nicholas A NA Department of Psychology, University of Hertfordshire, Herts, - - 2014
Following previous cross-sectional research adopting an evolutionary approach to social rank and eating disorders, the present study explored the predictive value of social rank for changes in eating disorder symptoms in a 6-month longitudinal study. Seventy-three women and men with a history of eating disorders were followed up over 6 months. ...
Sakamoto Mayumi - - 2013
ABSTRACT Background: Individuals with dementia often experience poor quality of life (QOL) due to behavioral and psychological symptoms of dementia (BPSD). Music therapy can reduce BPSD, but most studies have focused on patients with mild to moderate dementia. We hypothesized that music intervention would have beneficial effects compared with a ...
Shu Yun - - 2013
Labeling of viruses can be used to reveal viral infection pathways and screen potential anti-viral drugs. Complex procedures, including virus cultivation, purification and labeling are involved in traditional virus labeling methods. And the manipulation of living virus brings risk to researcher health. In this work, we report a general method ...
Bumb R A - - 2013
BACKGROUND: Radio-frequency-induced heat therapy (RFHT) has been found to be safe and effective against cutaneous leishmaniasis (CL) in short term, but its long-term efficacy is unclear. We compared the long-term efficacy of RFHT versus intralesional sodium stibogluconate (SSG) injections in treatment of CL in India. METHODS: One hundred patients with ...
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