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Results 651 - 700 of 3245
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Polyzotis Peter A - - 2013
BACKGROUND: <0.01). On a 5-point Likert scale, PCPs rated medication (4.65±0.74), patient care plan (4.43±0.87), and clinical status (4.33±0.94) as most important to include in a CR discharge summary. These were not provided in 18.8% (n=12), 4.7% (n=3), and 22.2% (n=14) of summaries, respectively.Conclusions-Approximately half of CR discharge summaries reach ...
Neumann Hartmut P H - - 2013
BackgroundAs we emerge into the genomic medicine era, the epidemiology of diseases is taken for granted. Accurate prevalence figures, especially of rare diseases (RDs, ≤50/100 000), will become even more important for purposes of health care and societal planning. We noticed that the numbers of affected individuals in regionally established ...
Zhang Qiong - - 2013
Quantitatively mapping surface properties with nanometer or even subnanometer resolutions is critical for advanced scanning probe microscopy (SPM) characterization. However, the characterization performance often suffers from noises and artifacts due to instrumentation or environmental limitations. In this paper, we proposed a novel statistical approach with bivariate spatial modeling to efficiently ...
Bellafante Elena - - 2013
Development of hepatic steatosis and its progression to steatohepatitis may be the consequence of dysfunction of several metabolic pathways, such as triglyceride synthesis, VLDL secretion and fatty acid β-oxidation. PGC-1β is a master regulator of mitochondrial biogenesis and oxidative metabolism, lipogenesis and triglyceride (TG) secretion. Here we generated a novel ...
Mandal S K - - 2013
Careful tuning of formation (calcination) temperature of Sr(2+) doped BiFeO(3) multiferroic ceramics results in tailorable particle morphologies ranging from spherical to pillar-like. Based on the minimization of Gibb's free energy approach, the dominant homogeneous mechanism for particle growth is suggested. The chemical substitution of a trivalent ion (Bi(3+)) by a ...
Parson Henri K - - 2013
Abstract Background: Small fiber peripheral neuropathy (SFN) is emerging as a common complication in diabetes. Currently there are few, not easily available methods of determining the integrity of small nerve fibers. This study was designed to determine the utility of a noninvasive technique, contact heat-evoked potential stimulation (CHEPS), on the ...
Ji Jia J The Comprehensive Cancer Center, College of Pharmacy, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio 43210, - - 2013
Flavopiridol, the first clinically evaluated cyclin-dependent kinase inhibitor, shows activity in patients with refractory chronic lymphocytic leukemia, but prevalent and unpredictable tumor lysis syndrome (TLS) presents a major barrier to its broad clinical use. The purpose of this study was to investigate the relationships between pretreatment risk factors, drug pharmacokinetics, ...
Gillig Kent - - 2013
The generally accepted view of protein structure in the gas-phase is that protein ions produced by electrospray ionization (ESI) exist in a number of different states and the resulting charge state distribution (CSD) and ion mobility spectrum is interpreted as evidence for protein ions retaining some memory of solution-phase conformation. ...
Zhang Jiliang - - 2013
Rare-earth metal germanides with the general formula RE(4)Ge(7) (RE = La, Ce, Pr, Nd, Sm) have been synthesized using the In-flux technique. Their structures have been established from single-crystal and powder X-ray diffraction, and the structural elucidation has been aided by electron diffraction. These compounds represent superstructures of the α-ThSi(2) ...
Silventoinen Karri - - 2013
The associations between height and reproductive success in humans have attracted long-time scientific interest, but in addition to rather mixed previous results, little is still known about the background mechanisms of these associations. We analyzed the association of adult height with age at first birth and lifetime reproductive success using ...
Hakouk Khadija - - 2013
For the very first time, sulfonium polyoxometalate (POM) assemblies are shown to develop efficient solid-state photochromism in ambient conditions. The optical properties of the already known Rb(0.75)(NH(4))(5.25)[(Mo(3)O(8))(2)O(O(3)PC(CH(2)S(CH(3))(2))OPO(3))(2)]·8H(2)O (1) and a new material (Me(3)S)(4)[Mo(8)O(26)] (2) under UV excitation are investigated by diffuse reflectance spectroscopy, revealing that the color change effect is ...
Vega-Sanchez Miguel - - 2013
(1,3; 1,4)-β-D-glucan, also known as mixed linkage glucan (MLG), is a polysaccharide that in flowering plants is unique to the cell walls of grasses and other related members of Poales. MLG is highly abundant in endosperm cell walls, where it is considered a storage carbohydrate. In vegetative tissues, MLG transiently ...
Pandolfini Tiziana - - 2013
Aucsia is a green plant gene family. In Angiosperms, Aucsia genes control several aspects of auxin biology, including polar auxin transport. AUCSIA miniproteins are produced via splicing of three exons. The first two exons span the conserved AUCSIA motif, while the third exon(s) encodes the more variable carboxyterminal end. AUCSIA ...
Foo Eloise - - 2013
As the newest plant hormone, strigolactone research is undergoing an exciting expansion. In less than five years, roles for strigolactones have been defined in shoot branching, secondary growth, root growth and nodulation, to add to the growing understanding of their role in arbuscular mycorrhizae and parasitic weed interactions. ( 1) ...
Friso Simonetta S Corresponding Author: Simonetta Friso, Department of Medicine, University of Verona School of Medicine, Policlinico G.B. Rossi, P.le L.A. Scuro, 10, 37134 Verona, Italy. - - 2013
Global DNA hypomethylation is an early molecular event in carcinogenesis. Whether methylation measured in peripheral blood mononuclear cells (PBMCs) DNA is a clinically reliable biomarker for early detection or cancer risk assessment is to be established. From an original sample-set of 753 male and female adults (ages 64.8 ± 7.3 ...
Smith David V - - 2013
The study of stroke patients with modern lesion-symptom analysis techniques has yielded valuable insights into the representation of spatial attention in the human brain. Here we introduce an approach--multivariate pattern analysis--that no longer assumes independent contributions of brain regions but rather quantifies the joint contribution of multiple brain regions in ...
Ge Xin - - 2013
The study is designed to investigate the changes of NKG2D expression on CD8(+) T cells and CD3(-) CD56(+) NK cells in Kawasaki disease (KD). NKG2D/NKG2A expression on CD3(-) CD56(+) NK cells and CD8(+) T lymphocytes, and NKG2D ligands such as major histocompatibility complex I chain related molecules A(MICA) and UL-16 ...
Jain Rinki R Center for Immunotherapeutic Research and Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Sciences Center, Abilene, TX 79601, - - 2013
Applications of trastuzumab are limited to breast cancer patients with high Her2-expressing tumors. We developed a T-cell receptor mimic (TCRm) monoclonal antibody (hereafter called RL1B) that targets the Her2-E75 peptide (residues 369-377)-HLA-A2 complex and examined its effects in Her2-expressing cancer cells. RL1B binding affinity was determined by surface plasmon resonance ...
Hung Yu-Shin - - 2013
This study aimed to compare the characteristics of patients with hematologic malignancies and solid cancers who received palliative care. A total of 124 patients with hematologic malignancy and 3032 patients with solid cancer, who received palliative care consultation services between 2006 and 2010 in a medical center in Taiwan, were ...
Kogame Akifumi - - 2013
6-Ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-3-(2,2,2-trifluoroethoxy)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide (TAK-441) is a potent, selective hedgehog signaling pathway inhibitor that binds to Smo and is being developed for the treatment of cancer. The objectives of these studies were to explore the possibility of establishing of a link between the pharmacokinetics of TAK-441 and the responses of Gli1 mRNA in ...
Wagener N N Department of Urology, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg 69120, - - 2013
The B-cell translocation gene 2 (BTG2) is considered to act as a tumour-suppressor gene because of its antiproliferative and antimigratory activities. Higher levels of BTG2 expression in tumour cells have been linked to a better clinical outcome for several cancer entities. Here, we investigated the expression and function of BTG2 ...
Apolloni Ann - - 2013
Here we show potent inhibition of HIV-1 replication in a human T cell line and primary human CD4+ cells by expressing a single antiviral protein. Nullbasic is a mutant form of the HIV-1 Tat protein that was previously shown to strongly inhibit HIV-1 replication in non-hematopoietic cell lines by targeting ...
Engel Tal - - 2013
OBJECTIVE:To report a case of acute pancreatitis in a patient receiving nilotinib for chronic myelogenous leukemia (CML).CASE SUMMARY:A 69-year-old man recently diagnosed with chronic phase CML received nilotinib 300 mg twice daily and was admitted with acute pancreatitis that appeared the day after the first dose. The patient had normal ...
Kainu Annette - - 2013
BACKGROUND: The continuing rise in asthma prevalence has been questioned, with recent reports suggesting a plateau. AIMS: To assess a 10-year trend in the age-adjusted prevalence of physician-diagnosed asthma, respiratory and allergic symptoms, and use of asthma medication in the adult population of Helsinki during the Finnish Asthma Programme from ...
Asmundson Gordon J G - - 2013
Research over the past few decades has focused on the therapeutic effects of physical exercise among those affected by mood disorders. Only recently has attention turned to maladaptive and persistent expressions of anxiety, with a growing body of evidence indicating promise for exercise as an effective treatment for some of ...
Liu Zhiting - - 2013
An eco-friendly, facile and scalable hydrothermal approach, in which the reduction and functionalization of graphite oxide (GO) are completed in one pot, is proposed for the synthesis of monolayer 3-aminopropyltriethoxysilane (APTES)-functionalized graphenes (A-FGs). Atomic force microscopy, transmission electron microscopy and x-ray diffraction analyses indicate that the as-synthesized A-FGs consist of ...
Pamies-Aubalat Lidia - - 2013
This study examined the Dieting Peer Competitiveness Scale; it is an instrument for evaluating this social comparison in young people. This instrumental study has two aims: The objective of the first aim was to present preliminary psychometric data from the Spanish version of the Dieting Peer Competitiveness Scale, including statistical ...
Isono Takayuki - - 2013
Purely organic materials are generally insulating. Some charge-carrier generation, however, can provide them with electrical conductivity. In multi-component organic systems, carrier generation by intermolecular charge transfer has given many molecular metals. By contrast, in purely organic single-component systems, metallic states have rarely been realized although some neutral-radical semiconductors have been ...
Saxena Richa R Center for Human Genetic Research and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, - - 2013
We performed a genome-wide association study (GWAS) and a multistage meta-analysis of type 2 diabetes (T2D) in Punjabi Sikhs from India. Our discovery GWAS in 1,616 individuals (842 case subjects) was followed by in silico replication of the top 513 independent single nucleotide polymorphisms (SNPs) (P < 10⁻³) in Punjabi ...
Pasquali Sandro - - 2013
Recently developed lymphatic-specific immunohistochemical markers can now be utilized to assess intra- and/or peritumorallymphatic vessel density (LVD), to detect lymphatic vessel invasion (LVI) by melanoma cells and to identify lymphatic marker expression in melanoma cells themselves. We systematically reviewed the available evidence for the expression of lymphatic markers as predictors ...
Bright Tara V - - 2013
A significant proportion of pharmaceuticals are fluorinated and selecting the site of fluorine incorporation can be an important beneficial part a drug development process. Here we describe initial experiments aimed at the development of a general method of selecting optimum sites on pro-drug molecules for fluorination, so that metabolic stability ...
Kumar Ravhi S - - 2013
The pressure-induced valence change of Yb in YbMn(2)Ge(2) has been studied by high pressure inelastic X-ray emission and absorption spectroscopy in the partial fluorescence yield mode up to 30 GPa. The crystal structure of YbMn(2)Ge(2) has been investigated by high pressure powder X-ray diffraction experiments up to 40 GPa. The ...
Wang Jin J Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, - - 2013
Cadherin-17 (CDH17), as a structurally unique member of the cadherin superfamily, has been identified to predict a poor prognosis for gastric cancer (GC). Our previous study demonstrated the positive correlation between CDH17 and lymph node micrometastasis in GC. We sought to further identify the role of CDH17 in the tumorigenesis ...
Burkin Heather R - - 2013
Focal adhesions are integrin-rich microdomains that structurally link the cytoskeleton to the extracellular matrix and transmit mechanical signals. In the pregnant uterus, increases in integrin expression and activation are thought to be critical for the formation of the mechanical syncytium required for labor. The aim of this study was to ...
Peyyala R R Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY 40536, USA. - - 2013
This report describes the use of a novel model of multispecies biofilms to stimulate profiles of cytokines/chemokines from oral epithelial cells that contribute to local inflammation in the periodontium. Streptococcus gordonii (Sg)/S. oralis (So)/S. sanguinis (Ss) and Sg/Fusobacterium nucleatum (Fn)/Porphyromonas gingivalis (Pg) biofilms elicited significantly elevated levels of IL-1α and ...
Cunningham D D Medical Oncology, Royal Marsden Hospital, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK. - - 2013
Cediranib is a highly potent inhibitor of vascular endothelial growth factor (VEGF) signalling with activity against all three VEGF receptors. Bevacizumab is an anti-VEGF-A monoclonal antibody with clinical benefit in previously treated metastatic colorectal cancer (mCRC). Patients with mCRC who had progressed following first-line therapy were randomised 1:1:1 to modified ...
Keil Julian - - 2013
We investigated the sound-induced flash illusion, an example for the influence of auditory information on visual perception. It consists of the perception of 2 visual stimuli upon the presentation of a single visual stimulus alongside 2 auditory stimuli. We used magnetoencephalography to assess the influence of prestimulus oscillatory activity on ...
Fraaije Johannes G E M - - 2013
We discuss the application of Helfrich's surface torque density concept to microemulsion design and analysis, from three different angles: (i) from the point of view of coarse-grained molecular simulations, using Dissipative Particle Dynamics, including charge interactions and added salt, (ii) using an approximate double film model for the surface, and ...
Vega-Frutis Rocío - - 2013
Sex-specific interactions with herbivores and pollinators have been observed in female and male plants of dioecious species. However, only a limited number of studies have revised sex-specific patterns in mycorrhizal symbiosis. To test whether female and male plants of Antennaria dioica differ in their relationship with arbuscular mycorrhizal (AM) fungi, ...
van de Kooij Bert - - 2013
The eleven members of the membrane-associated RING-CH (MARCH) ubiquitin ligase family are relatively unexplored. Upon exogenous (over)expression, a number of these ligases can affect the trafficking of membrane molecules. However, only for MARCH-1 endogenous functions have been demonstrated. For the other endogenous MARCH proteins, no functions or substrates are known. ...
Ozen Filiz - - 2013
Objectives: The aim of the current study was to investigate the prevalence and predictive significance of the KRAS and BRAF mutations in Turkish patients with colorectal cancer (CRC). Methods: Totally, 53 fresh tumoral tissue specimens were investigated in patients with CRC. All specimens were obtained during routine surgery of patients ...
Hernandez-Mijares Antonio A Service of Endocrinology, University Hospital Doctor Peset, Valencia, Spain. - - 2013
Diabetes is associated with oxidative stress and increased mortality, but a possible correlation between leukocyte-endothelium interactions, oxidative stress, and silent myocardial ischemia (SMI) is yet to be confirmed. Mitochondrial dysfunction and interactions between leukocytes and human umbilical vein endothelial cells were evaluated in 200 type 2 diabetic patients (25 with ...
Campbell Katrina L - - 2013
AIM: The aim of this study is to evaluate the breadth and depth of the allied health workforce providing renal services in Queensland, Australia. METHODS: Workforce statistics were reported for allied health renal services (excluding transplant) across all 14 publically funded regions across Queensland, Australia. Dietetics, pharmacy, podiatry, psychology and ...
Zhang Min - - 2013
A label-free assay is reported in this work for the detection of DNA with enhanced sensitivity using complex DNA structures (DNA tetrahedrons) based on the biolayer interferometry. The DNA tetrahedrons help to amplify the optical signals of the biolayer interferometry, thus improving the detection limit of DNA by about 100-fold. ...
Furman Olha - - 2013
As engineered nanoparticles (NPs) are increasingly used, their entry into the environment has become an important topic for water sustainability. Recent investigations point to the critical role of natural organic matter (NOM) in altering the persistence of NPs by complexing with their surfaces. The NP-NOM complex, in turn, is the ...
Jiang Jian-Hua - - 2013
Non-Abelian topological superconductors are characterized by the existence of zero-energy Majorana fermions bound in the quantized vortices. This is a consequence of the nontrivial bulk topology characterized by an odd Chern number. It is found that in topological semimetals with a single two-band crossing point all the gapped superconductors are ...
Bartnikas Tom B - - 2013
Background: Mutagenesis screens can establish mouse models of utility for the study of critical biological processes such as iron metabolism. Such screens can produce mutations in novel genes or the establishment of novel alleles of known genes, both of which can be useful tools for study. Design and Methods: To ...
Provenzano E - - 2013
Neo-tAnGo, a National Cancer Research Network (NCRN) multicentre randomised neoadjuvant chemotherapy trial in early breast cancer, enroled 831 patients in the United Kingdom. We report a central review of post-chemotherapy histopathology reports on the surgical specimens, to assess the presence and degree of response. A central independent two-reader review (EP ...
Dong Xuan - - 2013
The polyethylenimine (PEI) derivatives (PTn) are prepared by treating PEI25k with Tris(hydroxymethyl) acrylamidomethane via the Michael addition. These PTns can effectively condense nucleic acids into nanosized particles with positive surface charges. The PTns show lower cytotoxicity and better serum-resistant capacity than PEI25k. Specially, the transfection efficiency of PT26/DNA is 29-fold ...
King Shelby Marie - - 2013
Ovarian cancer is the deadliest gynecological malignancy due to detection at a late stage when the disease has metastasized. One likely progenitor cell type of ovarian cancer is the ovarian surface epithelium (OSE), which proliferates rapidly in the presence of inflammatory cytokines and oxidative stress following ovulation. To determine whether ...
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