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Leese G P - - 2013
AIMS: To determine whether geography and/or social deprivation influences the occurrence of foot ulcers or amputations in patients with diabetes METHODS: A population-based cohort of people with diabetes (n = 15 983) were identified between 2004 and 2006. Community and hospital data on diabetes care, podiatry care and onset of ulceration and amputation ...
Czarnecki Olaf - - 2013
The formation of 5-aminolevulinic acid (ALA) at the beginning of the pathway is the rate limiting step of tetrapyrrole biosynthesis and target of multiple timely and spatially organized control mechanisms. Recent discovery of a glutamyl-tRNA reductase-binding protein (GluTRBP), reveals a new insight in the topology of regulation of plant ALA ...
Charpentier Myriam - - 2013
Calcium (Ca ( 2+) ) is a key secondary messenger in many plant signaling pathways. One such pathway is the SYM pathway, required in the establishment of both arbuscular mycorrhizal and rhizobial root symbioses with legume host plants. ( 1) When the host plant has perceived the diffusible signals from ...
Huang Liming - - 2013
Germline mutations in genes that cause hereditary syndromes are highly predisposed to familial pancreatic cancer. However, genetic susceptibility to sporadic pancreatic cancer is largely uncovered. We conducted a two-stage association study on pancreatic cancer that included 981 cases and 1,991 controls in the first stage followed by a second stage ...
Holden Matthew T G MT The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB19 1SA, United - - 2013
The widespread use of antibiotics in association with high-density clinical care has driven the emergence of drug-resistant bacteria that are adapted to thrive in hospitalized patients. Of particular concern are globally disseminated methicillin-resistant Staphylococcus aureus (MRSA) clones that cause outbreaks and epidemics associated with health care. The most rapidly spreading ...
Karakus Ali - - 2013
Snakebites are relatively rare medical emergency cases that might lead to serious consequences. This study aims to evaluate snakebite cases in terms of medical follow-up, antivenom therapy and antivenom reactions. Medical records of patients admitted to emergency department between January 1, 2006 and December 31, 2010 were retrospectively investigated. Snakebite-related ...
Heinze Annekathrin - - 2013
Dendritic cells (DC) are the most potent antigen-presenting cells and are the key link between the innate and adaptive immune response. Only a few reports with study populations of up to 50 individuals have been published with age-based reference values for DC subpopulations in healthy children. Therefore, we aimed to ...
Tran Nguyen T D - - 2013
Triggered-release of encapsulated therapeutics from nanoparticles without remote or environmental triggers was demonstrated in this work. Disassembly of the polymer nanoparticles to unimers at precise times allowed the controlled release of oligo DNA. The polymers used in this study consisted of a hydrophilic block for stabilization and second thermoresponsive block ...
Delhanty Patric J D - - 2013
There is clinical evidence that des-acyl ghrelin (DAG) favorably modulates glucose and lipid metabolism, although its mode of action is unknown. A murine model of prediabetes was used to assess possible mechanisms of action for DAG and a newly developed bioactive analog, AZP531. C57BL/6J mice were infused with saline, DAG, ...
Robinson Mark - - 2013
This paper examines the value of participatory approaches within interventions aimed at promoting mental health and wellbeing in the workplace. Specifically the paper explores data from the thematic evaluation of the Mental Health and Employment project strand within the Altogether Better programme being implemented in England in the Yorkshire and ...
Fan Pengyu - - 2013
At the nanoscale, semiconductor and metallic structures naturally exhibit strong, tunable optical resonances that can be utilized to enhance light-matter interaction and to dramatically increase the performance of chipscale photonic elements. Here, we demonstrate that the metallic leads used to extract current from a Ge nanowire (NW) photodetector can be ...
Pristov Jelena Bogdanović - - 2013
In contrast to the damaging effects of high doses, low dose radiation (UV, gamma) has been reported to provoke constructive changes in plants. However, the mechanisms by which plants recognize and respond to low dose radiation are not understood. We have shown recently that polygalacturonic acid, cell wall polysaccharide, converts ...
Kim Jungmook - - 2013
Root system architecture is important for plants to adapt to a changing environment. The major determinant of the root system is lateral roots originating from the primary root. The developmental process of lateral root formation can be divided into priming, initiation, primordium development and the emergence of lateral roots, and ...
Li Shundai - - 2013
In higher plants, cellulose is synthesized by cellulose synthase complexes, which contain multiple isoforms of cellulose synthases (CESAs). Among the total 10 CESA genes in Arabidopsis, recessive mutations at three of them cause the collapse of mature xylem cells in inflorescence stems of Arabidopsis (irx1 (cesa8) , irx3 (cesa7) and ...
Galanaud J-P - - 2013
Deep-vein thrombosis (DVT) is a common disease. However, unlike varicose veins that have been depicted since antiquity in art and literature, its description was more recent in the history of medicine. The first well-documented case of DVT was reported during the Middle Ages: in 1271 Raoul developed an unilateral edema ...
Bendali Amel - - 2013
The excellent cytocompatibility of single-layer CVD graphene is demonstrated by showing that primary adult retinal ganglion cells can directly survive on its surface without any supporting glial layer or protein coating. These results confirm the great potential of graphene as a biocompatible material for interfacing neurons, opening a new route ...
Semrouni David - - 2013
The structures, dynamics and energetics of the protonated, derivatized peptide DyeX-(Pro)(4)-Arg(+)-Trp, where "Dye" stands for the BODIPY analog of tetramethyl-rhodamine and X is a (CH(2))(5) linker, have been investigated using a combination of modeling approaches in order to provide a numerical framework to the interpretation of fluorescence quenching data in ...
Rana M S - - 2013
Perturbations in cardiac development result in congenital heart disease, the leading cause of birth defect-related infant morbidity and mortality. Advances in cardiac developmental biology have significantly augmented our understanding of signalling pathways and transcriptional networks underlying heart formation. Cardiogenesis is initiated with the formation of mesodermal multipotent cardiac progenitor cells, ...
Kim Jiyun - - 2013
A magnetically tunable chromatic nanocomposite microactuator is proposed, which utilizes the optical and magnetic behaviors of self-assembled super-paramagnetic nanoparticles fixed in a polymeric microstructure. The original color can be programmed during a simple photolithography process, and the color can be changed just by applying and changing an external magnetic field. ...
Xu Yongqian - - 2013
The first "off-on" dual-output fluorescent assay based on reaction-promoted self-assembly approach for glutathione recognition in near infrared region over other relative thiols including cysteine and homocysteine was constructed with high selectivity and large Stocks shift (about 220 nm). The fluorescence enhancement is attributed to the intermolecular interaction, which manipulates the ...
Cook Deborah - - 2013
ABSTRACT: INTRODUCTION: Research on coenrolment practices and its impact are limited in the ICU setting. The objectives of this study were; 1) to describe patterns and predictors of coenrolment of patients in a thromboprophylaxis trial, and 2) to examine the consequences of coenrolment on clinical and trial outcomes. METHODS: In ...
Zhang Zhanxia - - 2013
Fluorescent dyes methylene blue, MB+, or thionine, Th+, are trapped in the pores of mesoporous silica, MP-SiO2, by means of functional nanostructures, consisting of the Mg2+- or Zn2+-dependent DNAzyme sequences. In the presence of Mg2+- or Zn2+-ions the respective DNAzymes are activated, leading to the specific cleavage of the respective ...
Balia Filippo - - 2013
The effect of CSN1S1 genotype and lactation stage on milk yield and composition were investigated in 80 extensively reared goats. Milk yield was recorded in early, mid and late lactation and individual milk samples were collected to determine: fat, protein, lactose and casein content, pH, freezing point, somatic cell count ...
Soria Leandro R - - 2013
Hepatocyte mitochondrial ammonia detoxification via ureagenesis is critical for prevention of hyperammonemia and hepatic encephalopathy. Aquaporin-8 (AQP8) channels facilitate the membrane transport of ammonia. Since AQP8 is expressed in hepatocyte inner mitochondrial membranes, we studied whether mitochondrial AQP8 (mtAQP8) plays a role in ureagenesis from ammonia. Primary cultured rat hepatocytes ...
Sanlıer Senay Hamarat - - 2013
Laccase played an important role in the decolorization of wide spectrum dyes as a low-cost and environmentally friendly technology. Laccase was immobilized in alginate beads and immobilization conditions were identified. 25 mg/ml laccase enzyme encapsulation efficiencies of using the prepared bead was calculated as approximately 94%. At the end of ...
Wang Nasui N Div. of Endocrinology and Metabolism, Dept. of Medicine, Univ. of Virginia Health System, Charlottesville, VA 22908, - - 2013
Insulin delivery and transendothelial insulin transport are two discrete steps that limit muscle insulin action. Angiotensin II type 1 receptor (AT1R) blockade recruits microvasculature and increases glucose use in muscle. Increased muscle microvascular perfusion is associated with increased muscle delivery and action of insulin. To examine the effect of acute ...
Minisini Rosalba - - 2013
BACKGROUND: Alcohol is a major determinant of the outcome of chronic hepatitis C virus (HCV) infection, but self-reported drinking habits lack reliability. We hypothesized that carriage of high-repetition variants (HRV) of the variable number of tandem repeats (VNTR) in exon III of the dopamine receptor D(4) gene, linked to binge-drinking ...
Sroubek Ariane - - 2013
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with a long-term impact on functioning, productivity and quality of life of patients. This impact is largely due to the symptoms of inattentiveness. However, despite its impairing role in the lives of ADHD patients, inattentiveness has been studied relatively less frequently than have ...
Siebert Adam P AP Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6085, - - 2013
CALHM1 (calcium homeostasis modulator 1) forms a plasma membrane ion channel that mediates neuronal excitability in response to changes in extracellular Ca(2+) concentration. Six human CALHM homologs exist with no homology to other proteins, although CALHM1 is conserved across >20 species. Here we demonstrate that CALHM1 shares functional and quaternary ...
Zhang Yue - - 2013
Binding between β-lactoglobulin (β-Lg), the major whey protein, and bixin, the major carotenoid in annatto, was studied at pH 3.0-10.0. The Fourier-transform infrared spectroscopy and UV-vis absorption spectroscopy results showed that the binding involved a complex formation. The tryptophan quenching fluorescence and analytical ultracentrifugation data showed that there were two ...
Hsieh Ching-Chuan CC Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, - - 2013
Myeloid-derived suppressor cells (MDSCs) play an important role in the regulation of the immune response. MDSC expansion occurs in many circumstances, including cancer, inflammation, stresses, and transplant tolerance. Liver transplants in mice are spontaneously accepted, but hepatocyte transplants are acutely rejected, suggesting the immunoregulatory activities of liver nonparenchymal cells. We ...
Björkander Sophia - - 2013
Monocytes are precursors of macrophages and recruited to the uterus throughout pregnancy to perform important immunological functions. In this study we hypothesized that pregnant women have reduced peripheral monocyte expression ofchemokine receptors and alterations in PBMC responses to microbial stimuli as an adaption to pregnancy and that these changes are ...
You Shujie - - 2013
A structural study of swelling of Hummers graphite oxide (H-GO) in excess of liquid alcohols was performed as a function of temperature using synchrotron X-ray diffraction and revealed a strong "negative thermal expansion" effect. The increase of the distance between graphene oxide layers is explained by insertion of additional solvent ...
Yang Hee-Young - - 2013
MHC class II molecules, in addition to their essential role as antigen-presenting molecules to CD4(+) T cell receptor, have a signal-transducing role related to B cell function. We identified pro-IL-16 as one of the proteins associated with MHC class II-mediated signaling in an analysis of MHC class II-associated molecules using ...
Huang Liang Feng - - 2013
The electronic structure of zigzag graphene nanoribbon (ZGNR) is studied using density functional theory. The mechanisms underlying the quantum-confinement effect and edge magnetism in ZGNR are systematically investigated by combining the simulated results and some useful analytic models. The quantum-confinement effect and the inter-edge superexchange interaction can be tuned by ...
Brunetti Giacomina - - 2013
Children with 21-hydroxylase deficiency (21-OHD) need chronic glucocorticoid (cGC) therapy to replace congenital deficit of cortisol synthesis and this therapy is the most frequent and severe form of drug-induced-osteoporosis. We found in 21-OHD patients high serum and leukocyte levels of dickkopf-1 (DKK1), a secreted antagonist of the Wnt/β-catenin signaling pathway, ...
Islamoğlu S - - 2013
We investigate the Hall conductance of graphene with point defects within the Kubo formalism, which allows us to calculate the Hall conductance without constraining the Fermi energy to lie in a gap. For pure graphene, which we model using a tight-binding Hamiltonian, we recover both the usual and the anomalous ...
Mawani Yasmin - - 2013
Lanthanide ions, Ln(iii), are of interest in the treatment of bone density disorders because they are found to accumulate preferentially in bone (in vivo), have a stimulatory effect on bone formation, and exhibit an inhibitory effect on bone degradation (in vitro), altering the homeostasis of the bone cycle. In an ...
Mureddu Gian Francesco - - 2013
Cardiovascular (CV) risk prediction has a central role in primary CV prevention. Several risk charts have been developed in the attempt to identify subjects at risk who might benefit from more aggressive interventions. However, risk charts show main limitations and they remain underutilized in general practice. The addition of novel ...
Flick Matthew J MJ Division of Experimental Hematology and Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, - - 2013
Fibrinogen can support host antimicrobial containment/clearance mechanisms, yet selected pathogens appear to benefit from host procoagulants to drive bacterial virulence. Here, we explored the hypothesis that host fibrin(ogen), on balance, supports Staphylococcus aureus infection in the context of septicemia. Survival studies following intravenous infection in control and fibrinogen-deficient mice established ...
Willett Peter - - 2013
Data fusion was first developed for combining sensor outputs for military applications; when used for similarity-based virtual screening, the sensor outputs that are combined are the database rankings that result from multiple similarity searches. The expectation, which is often the case in practice, is that such combined rankings will have ...
Begriche Karima - - 2013
The worldwide epidemic of obesity and insulin resistance favours nonalcoholic fatty liver disease (NAFLD). Insulin resistance (IR) in the adipose tissue increases lipolysis and the entry of non-esterified fatty acids (NEFAs) in the liver, whereas IR-associated hyperinsulinemia promotes hepatic de novo lipogenesis. However, several hormonal and metabolic adaptations are set ...
Li Chaoyang C Division of Behavioral Surveillance, Public Health Surveillance&Informatics Program Office, Office of Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. - - 2013
To estimate the prevalence of diagnosed cancer according to duration of diagnosed diabetes and current insulin use among U.S. adults with diagnosed diabetes. We analyzed data from 25,964 adults aged ≥ 18 years with diagnosed diabetes who participated in the 2009 Behavioral Risk Factor Surveillance System. After adjustment for potential ...
Chang Chung-Te CT Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, - - 2013
The TREX complex couples nuclear pre-mRNA processing with mRNA export and contains multiple protein components, including Uap56, Alyref, Cip29 and the multi-subunit THO complex. Here, we have identified Chtop as a novel TREX component. We show that both Chtop and Alyref activate the ATPase and RNA helicase activities of Uap56 ...
Ten Cate David F - - 2013
ABSTRACT: INTRODUCTION: Ultrasonography (US) might have an added value to clinical examination in diagnosing early rheumatoid arthritis (RA) and assessing remission of RA. We aimed to clarify the added value of US in RA in these situations performing a systematic review. METHODS: A systematic literature search was performed for RA, ...
Wilkinson Eric P EP House Ear Clinic, Los Angeles, California 90057, USA. - - 2013
Voice conversion algorithms may benefit cochlear implant (CI) users who better understand speech produced by one talker than by another. It is unclear how the source or target talker's fundamental frequency (F0) information may contribute to perception of converted speech. This study evaluated voice conversion algorithms for CI users in ...
Ambrose Christopher S - - 2013
The Vaccines for Children (VFC) program distributes one half of all vaccines administered to US children. Compared with commercial vaccine distribution, VFC distribution is more complex. This prospective observational study compares the delivery and administration of VFC versus non-VFC influenza vaccine in US pediatricians' offices across 3 influenza seasons and ...
Tse Hung-Fat HF Cardiology Division, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China. - - 2013
In this paper, we report a novel heterozygous mutation of A285V codon conversion on exon 4 of the desmin (DES), using whole exome sequencing (WES) in an isolated proband with documented dilated cardiomyopathy (DCM). This mutation is predicted to cause three-dimensional structure changes of DES. Immunohistological and electron microscopy studies ...
Chalkley Robert J - - 2013
To address problems with estimating the reliability of proteomic search engine results from mass spectrometry fragmentation data the use of target-decoy database searching has become the de facto approach for estimating a false discovery rate. Several articles have been written about the effects of different ways of creating the decoy ...
Wang Pengcheng - - 2013
Reactive oxygen species (ROS) have been characterized as both important signaling molecules and universal stressors that mediate many developmental and physiological responses. So far, details of the transcriptional mechanism of ROS-responsive genes are still largely unknown. In the study reported herein, we identified seven potential ROS-responsive cis-acting elements (ROSEs) from ...
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