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Results 501 - 550 of 3245
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Mergenthaler Philipp P Department of Experimental Neurology, Charitéplatz, Berlin, - - 2013
Hypoxic preconditioning is thought to rely on gene products regulated by hypoxia-inducible factor (HIF)-1. Here, we show that the HIF-1 target gene cyclin-dependent kinase inhibitor 1, p21(WAF1/CIP1), is essential for neuroprotection by hypoxic/aglycemic or erythropoietin preconditioning using wild-type and p21(WAF1/CIP1)-deficient neurons. Furthermore, overexpression of wild-type p21(WAF1/CIP1) or phospho-mutants significantly increased ...
Chua Fook K - - 2013
Previous studies of top-down attentional guidance have focused generally on the attentional prioritization of a single target feature. The present study focused on how the attentional system would be configured when the target possesses several unique features. These features were perfectly correlated, which meant that monitoring just one of them ...
Wang Jiahui - - 2013
Purpose   Golden retriever muscular dystrophy (GRMD) is a widely used canine model of Duchenne muscular dystrophy (DMD). Recent studies have shown that magnetic resonance imaging (MRI) can be used to non-invasively detect consistent changes in both DMD and GRMD. In this paper, we propose a semiautomated system to quantify MRI biomarkers ...
Baughman Holly M - - 2013
This replication study examines relations between alexithymia and trait emotional intelligence (trait EI) at the phenotypic, genetic, and environmental levels. A sample of 1,444 same-sex twin pairs (850 MZ pairs and 594 DZ pairs) completed the Toronto Alexithymia Scale-20. A subset of 494 same-sex twin pairs (287 MZ pairs and ...
Kaneko Yuka - - 2013
BACKGROUND: KRAS mutation is widely accepted as a strong, negative predictive marker for anti-epidermal growth factor receptor antibodies, including cetuximab and panitumumab. Previous reports demonstrated approximately 100 % concordance of KRAS status between primary colorectal cancer and liver metastases; however, mismatched KRAS status still occurs. METHODS: KRAS status was evaluated in ...
Zhang Jinying J Research Laboratory of Biochemistry, Basic Medical Institute, General Hospital of the Chinese People's Liberation Army and Military Medical Postgraduate College, Beijing, PR - - 2013
The purpose of this study was to investigate the protective mechanism of leptin-mediated metabolic recovery against cerebral injury after ischemia and reperfusion. We determined the neurologic deficit score, extent of brain edema, and infarct volume after reperfusion. The histopathologic alterations and changes in glucose uptake in the brain were also ...
Salman Saeed - - 2013
Dietary selenium (Se) can be supplemented from organic or inorganic sources and this may affect Se metabolism and functional outcome such as antioxidative status and immune functions in dairy cows. A feeding trial was performed with 16 Holstein-Friesian dairy cows fed with a total mixed ration (0.18 mg Se/kg dry ...
Dietz de Loos Dirk A E - - 2013
Quality of life (QoL) measurements are the best approximation of the burden of disease for the patient. Patient-reported outcome measurements (PROMs) estimate health-related quality of life (HRQoL). PROMs can be generic or disease-specific. Generic PROMs allow comparisons between different diseases but can be relatively insensitive for measuring changes within a ...
Ye Fanghui - - 2013
PURPOSE: Genetic variations are related to individual differences of DNA repair ability and drug metabolism, which can greatly influence prognosis of antineoplastic agents, such as oxaliplatin. The aim was to explore the influences of X-ray repair cross-complementing 1(XRCC1) and Glutathione S-transferase P1 (GSTP1) genetic variants on prognosis of oxaliplatin-based chemotherapy ...
Schuck Patrícia F - - 2013
Abstract Tissue methylmalonic acid (MMA) accumulation is the biochemical hallmark of methylmalonic acidemia. The disease is clinically characterized by progressive neurological deterioration and kidney failure, whose pathophysiology is still unclear. In the present work we investigated the effects of acute MMA administration on various parameters of oxidative stress in cerebral ...
Fowler John - - 2013
This series of articles is designed to help you advance your nursing practice; it begins by exploring the motivation to advance your practice and the differences between specialist and advanced practice.
Piazza Gregory G Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115, USA. - - 2013
The US Surgeon General estimates that 100,000 to 180,000 deaths occur annually from acute pulmonary embolism (PE) in the United States. The case of Ms A, a 60-year-old woman with acute PE and right ventricular dysfunction (submassive PE), illustrates the clinical challenge of identifying this high-risk patient population and determining ...
Molina A - - 2013
A key concept underpinning electrochemical science is that of the diffusion layer - the zone of depletion around an electrode accompanying electrolysis. The size of this zone can be found either from the simulated or measured concentration profiles (yielding the 'true' diffusion layer thickness) or, in the case of the ...
Hong Yong Sang - - 2013
The goal of the present study was to compare the combination of cetuximab and irinotecan to the combination of oxaliplatin and fluoropyrimidines as second-line chemotherapy in patients with irinotecan-refractory and oxaliplatin-naïve metastatic colorectal cancer (mCRC) harbouring wild-type KRAS. The study included 120 patients with mCRC who had progressed after irinotecan-containing ...
Zhang Zhi-Ling - - 2013
The reporting of complications following transperitoneal and retroperitoneal open radical nephrectomy (RN) is nonstandardized. The aim of this study was to compare early complications between the two approaches using a standardized reporting methodology in a large contemporary cohort. Between 1996 and 2009, 558 patients underwent open RN for renal cell ...
Buglione Antonio - - 2013
The aim of this study was to: (1) determine directly the energy cost of shuttle running (C (Sh)) and (2) compare it to the values indirectly estimated from kinematic data. C (Sh) over distances of ≈10 or ≈20 m was determined on 65 subjects (group 1) from gas exchange measurements over ...
Kim Yong Seung - - 2013
A single-layer graphene is synthesized on Cu foil in the absence of H(2) flow by plasma enhanced chemical vapor deposition (PECVD). In lieu of an explicit H(2) flow, hydrogen species are produced during the methane decomposition process into their active species (CH(x<4)), assisted with the plasma. Notably, the early stage ...
Leite Andreia - - 2013
In the present work we describe the structure and the spectroscopic characterization of a spirocyclic derivative of a rhodamine B ligand whose properties allow discrimination of light-up effects induced by metal ion chelation and variation of pH. Distinction of the two effects is important for the use of this type ...
Li Hua - - 2013
The supportive and negative evidence for the stress gradient hypothesis (SGH) led to an ongoing debate among ecologists and called for new empirical and theoretical work. In this study, we took various biological soil crust (BSCs) samples along a spatial gradient with four environmental stress levels to examine the fitness ...
Mlosek Robert K - - 2013
INTRODUCTION: The appropriate skin hydration level enables its normal function and healthy appearance. PURPOSE: The purpose of present research was to assess the applicability of high frequency ultrasound (HFU) to the monitoring of skin moisturization treatments. MATERIAL AND METHODS: The study sample encompassed 27 women, aged 20-67 y.o. (mean age ...
Ryu Min Ju - - 2013
This study investigated the mechanisms underlying the cytotoxicity of the green algae Ulva fasciata Delile. U. fasciata extract (UFE) inhibited the growth of HCT 116 human colon cancer cells by 50% at a concentration of 200 μg/ml. In addition, UFE stimulated the production of intracellular reactive oxygen species, an effect that ...
Rahman Shakibur - - 2013
BACKGROUND: Worldwide studies on lung adenocarcinoma have demonstrated a genetic divergence of the epidermal growth factor receptor (EGFR) pathway according to ethnicity, such as higher frequency of activated EGFR mutations among East Asian patients. However, such information is still lacking in some developing countries. METHODS: We investigated the frequency of ...
Narita Yusaku - - 2013
5-Caffeoylquinic acid (5-CQA) is generally referred to as chlorogenic acid, and exhibits various biological activities such as antioxidant activity and porcine pancreas α-amylase inhibitory activities. 5-CQA may be useful as an antioxidant for food and to prevent diabetes and obesity. The degradation of 5-CQA and caffeic acid (CA) in an ...
Wu Xiaodan - - 2013
ABSTRACT: Translational science consists of research and development that integrates multiple resources to expedite the successful treatment of disease. The International Park of Translational BioMedicine (IPTBM) is currently being developed within the interface between Zhejiang Province and Shanghai Municipality. IPTBM has been designed to pioneer comprehensive biomedical research that spans ...
Kiecolt K Jill KJ Department of Sociology, Virginia Tech, Blacksburg, VA 24061, USA. - - 2013
Sense of mastery, a personal resource, is likely to have an inverse association with alcohol dependence. Previous evidence, however, is sparse. In addition, the extent to which an association is due to genetic or environmental factors is unknown. Data were from 3,983 male twins and 2,630 female twins who had ...
Rutland Bronwyn E - - 2013
A 4-month-old female kitten presented with chronic lower urinary tract signs and Escherichia coli cystitis, and was diagnosed with urinary bladder malakoplakia based upon histopathology. The kitten was treated with a prolonged antibiotic course and the malakoplakia resolved. Malakoplakia is a chronic granulomatous reaction characterized by the formation of Michaelis-Gutman ...
Do H T T HT Department of Epidemiology and Preventive Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, - - 2013
We investigated the aetiologic role of human papillomavirus (HPV) in 120 penile squamous cell carcinomas (PSCCs) from Vietnam. Human papillomavirus DNA was detected by PCR using SPF10 primers and a primer set targeting HPV-16 E6. The INNO-LiPA HPV genotyping kit was used to determine genotype. Human papillomavirus-16 viral load and ...
Goellner Esther Marie - - 2013
Arabinogalactan-proteins are glycoproteins that occur in higher plants and are involved in important processes like cell differentiation and plant growth. In the medicinal plant Echinacea purpurea L., they belong to the putative immunomodulating compounds and are structurally well characterized. For microscopic localization of arabinogalactan-proteins, synthetic (β-D-Glc)3 Yariv phenylglycoside that specifically ...
Atanasova Iliyana P IP Department of Radiology, Center for Biomedical Imaging, New York University School of Medicine, New York, New York 10016, USA. - - 2013
To improve robustness to patient motion of "fresh blood imaging" (FBI) for lower extremity noncontrast MR angiography. In FBI, two sets of three-dimensional fast spin echo images are acquired at different cardiac phases and subtracted to generate bright-blood angiograms. Routinely performed with a single coronal slab and sequential acquisition of ...
Salvaudon Lucie - - 2013
Tomato Yellow Leaf Curl China Virus spreads together with its invasive vector, the silverleaf whitefly B biotype, which exhibits higher growth rates on infected plants. Previous studies indicate that the virus satellite gene βC1 accounts for the visible symptoms of infection and inhibits the constitutive expression of jasmonic acid (JA)-a ...
Palmroth Sari S Nicholas School of the Environment, Box 90328, Duke University, Durham, NC 27708, USA. - - 2013
Water and nitrogen (N) are two limiting resources for biomass production of terrestrial vegetation. Water losses in transpiration (E) can be decreased by reducing leaf stomatal conductance (g(s)) at the expense of lowering CO(2) uptake (A), resulting in increased water-use efficiency. However, with more N available, higher allocation of N ...
Chandra Phool - - 2013
Ethnopharmacological relevance: Lygodium flexuosum (Linn) Sw. is a climbing fern, and it is the sole genus in the family Lygodiaceae. It commonly grows epiphytically on moss covered tree trunks and branches as lithophytes on shady boulders along with moss. It has been reported as a traditional folkloric medicine for a ...
Sri D D Department of Neurosurgery, Addenbrooke's Hospital , Cambridge , - - 2013
Spinal Dural Fistulas (SDAVF) are the most common Spinal Vascular Malformation. The management of SDAVFs has revolved around embolization or surgical interruption. The management strategy employed at this centre is to attempt embolization as first line therapy and to opt for surgery in the event of failure. This retrospective study ...
Celik Yeliz - - 2013
Antifreeze proteins (AFPs) are a subset of ice-binding proteins that control ice crystal growth. They have potential for the cryopreservation of cells, tissues, and organs, as well as for production and storage of food and protection of crops from frost. However, the detailed mechanism of action of AFPs is still ...
Brault Norman D - - 2013
Protein arrays are a high-throughput approach for proteomic profiling vital for achieving a greater understanding of biological systems in addition to disease diagnostics and monitoring therapeutic treatments. In this work, zwitterionic carboxybetaine polymer (pCB) coated substrates were investigated as an array surface platform to enable convenient amino-coupling chemistry on a ...
Lee Wonjoo - - 2013
We present a novel and simple method for forming hexagonal gold nanoparticle arrays that uses Coulombic interactions between negatively charged gold nanoparticles on positively charged vertically oriented poly(4-vinylpyridine) cylinders formed in a spin cast polystyrene-b-poly(4-vinylpyridine) block copolymer film. Exposure of the block copolymer film to dibromobutane vapor quaternizes and crosslinks ...
Hensgens Marjolein P M - - 2013
Background. Mortality among patients with Clostridium difficile infections (CDI) is high. Because of high age and multiple underlying diseases, CDI-related mortality is difficult to estimate. We estimated (CDI-related) mortality in an endemic situation, not influenced by outbreaks and consequently certain patients and C. difficile strains.Methods. Between 2006 and 2009, 13 Dutch hospitals ...
Dewire Scott M - - 2013
The concept of ligand bias at G protein-coupled receptors broadens the possibilities for agonist activities and provides the opportunity to develop safer, more selective therapeutics. Morphine pharmacology in beta-arrestin2 knock out mice suggested that a ligand that promotes coupling of the mu-opioid receptor (MOR) to G proteins, but not beta-arrestins, ...
Guo Siyu - - 2013
OBJECTIVES: To determine rates of carriage of fluoroquinolone-resistant Escherichia coli and extraintestinal pathogenic E. coli (ExPEC) among dogs in a specialist referral hospital and to examine the population structure of the isolates. METHODS: Fluoroquinolone-resistant faecal E. coli isolates (nā€Š=ā€Š232, from 23 of 123 dogs) recovered from hospitalized dogs in a ...
Liao S Y SY Department of Epidemiology, University of California, Irvine, School of Medicine, Irvine, CA, - - 2013
Lobular endocervical glandular hyperplasia (LEGH) is a rare lesion of the uterine cervix. It has been proposed that LEGH may represent a precursor lesion to a group of mucinous adenocarcinoma with gastric phenotype (GA) that is independent of high-risk human papillomavirus (H-HPV) infection. Carbonic anhydrase-IX (CA-IX) is highly expressed in ...
Brusa Davide - - 2013
Background. Chronic lymphocytic leukemia is marked by profound defects in T cell function. Programmed death-1 is a receptor involved in tumor-mediated immunosuppression through binding of the PD-L1 ligand. Design and Methods. Multiparameter flow cytometry and immunohistochemistry were used to study PD-1/PD-L1 expression. Functional assays were used to determine the involvement ...
Sirianni Giulia - - 2013
Complex and flexible food processing was a key element for the evolutionary success of hominins, enlarging the range of exploitable foods while enabling occupation of new habitats. Only a few primate species crack open encased food by using percussive tools and/or avoid physical contact with irritant compounds by removing the ...
Lahti Laura S - - 2013
The midbrain GABAergic neurons control several aspects of behaviour, play important roles in psychiatric disease and are targets of medical treatments as well as drugs of abuse. However, their molecular diversity and regulation of development are only beginning to be understood. In this review we briefly introduce distinct subpopulations of ...
Carpiniello B - - 2013
Background: The Authors sought to evaluate current prevalence of mental disorders in patients affected by metabolic syndrome compared with patients affected by central obesity alone. Methods: 186 (63.5%) patients affected by central obesity and 107 (36.5%) affected by metabolic syndrome according to ICF criteria were interviewed by means of SCID ...
Hoffman-Censits Jeannie - - 2013
Enzalutamide (MDV3100, Xtandi, Medivation\Astellas) is an oral inhibitor of androgen receptor signaling which blocks androgen-receptor interaction; inhibits translocation of the androgen receptor to the nucleus; impairs androgen receptor binding to DNA; and inhibits co-activator recruitment and receptor mediated DNA transcription. In a Phase III randomized study comparing Enzalutamide to placebo ...
Wang Meina - - 2013
ABSTRACT: INTRODUCTION: Osteoarthritis (OA) is a degenerative joint disease affecting a large population of people. The mechanism of this highly-prevalent disease is not fully understood. Currently there is no effective disease-modifying treatment for OA. The purpose of this study was two-folds: 1) to investigate the role of MMP13 in the ...
Lun Yu - - 2013
ObjectiveHashimoto's thyroiditis (HT) has been associated with an elevated risk of papillary thyroid cancer (PTC). To investigate the possible influence of HT on the prognosis of PTC patients, we assessed the related clinical factors linking these conditions, especially serum thyroid-stimulating hormone (TSH) concentration.Study DesignCase-control study.SettingThe First Hospital of China Medical ...
Michou Emilia E University of Manchester, Manchester, - - 2013
Several stimulation parameters can influence the neurophysiological and behavioral effects of paired associative stimulation (PAS), a neurostimulation paradigm that repeatedly pairs a peripheral electrical with a central cortical (transcranial magnetic stimulation [TMS]) stimulus. This also appears to be the case when PAS is applied to the pharyngeal motor cortex (MI), ...
Soriano Aileen - - 2013
Diencephalic storms or paroxysmal sympathetic storms are characterized by episodic hyperhidrosis, hypertension, tachypnea, tachycardia, and abnormal posturing. These have been reported to occur in patients with hydrocephalus, intracranial tumors, and hypoxic, ischemic, or traumatic brain injury. They can be easily misdiagnosed as seizures, uncontrolled pheochromocytoma, drug withdrawal, thyroid storm, hypertensive ...
Gadel Sarah S Department of Anesthesiology, Division of Clinical and Translational Research, Washington University in St. Louis, St. Louis, Missouri 63110-1093, - - 2013
The long-acting opioid methadone displays considerable unexplained interindividual pharmacokinetic variability. Methadone metabolism clinically occurs primarily by N-demethylation to 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), catalyzed predominantly by CYP2B6. Retrospective studies suggest that the common allele variant CYP2B6*6 may influence methadone plasma concentrations. The catalytic activity of CYP2B6.6, encoded by CYP2B6*6, is highly substrate-dependent. This ...
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