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Results 501 - 550 of 3239
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Bao Dang Quoc Q INSERM UMR698, Paris, - - 2013
Breakdown of the blood-brain barrier (BBB) is a key step associated with ischemic stroke and its increased permeability causes extravasation of plasma proteins and circulating leukocytes. Polymorphonuclear neutrophil (PMN) proteases may participate in BBB breakdown. We investigated the role of PMNs in ischemic conditions by testing their effects on a ...
Pillai Deepu R DR Department of Neurology, Regensburg University Medical Centre, Regensburg, - - 2013
The 'new penumbra' concept imbues the transition between injury and repair at the neurovascular unit with profound implications for selecting the appropriate type and timing of neuroprotective interventions. In this conceptual study, we investigated the protective effects of pigment epithelium-derived factor (PEDF) and compared them with the properties of epidermal ...
Qin Mei M Section on Neuroadaptation and Protein Metabolism, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, - - 2013
Dysregulated protein synthesis is thought to be a core phenotype of fragile X syndrome (FXS). In a mouse model (Fmr1 knockout (KO)) of FXS, rates of cerebral protein synthesis (rCPS) are increased in selective brain regions. We hypothesized that rCPS are also increased in FXS subjects. We measured rCPS with ...
Sim Jae Hoon JH Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Frauenkliniksrasse 24, 8091, Zurich, Switzerland. - - 2013
The accuracy of any stapes model relies on the accuracy of the anatomical information upon which it is based. In many previous models and measurements of the stapes, the shape of the stapes has been considered as symmetric with respect to the long and short axes of the footplate. Therefore, ...
McAlindon Timothy T Division of Rheumatology, Tufts Medical Center, Box 406, 800 Washington St, Boston, MA 02111, USA. - - 2013
Knee osteoarthritis (OA), a disorder of cartilage and periarticular bone, is a public health problem without effective medical treatments. Some studies have suggested that vitamin D may protect against structural progression. To determine whether vitamin D supplementation reduces symptom and structural progression of knee OA. A 2-year randomized, placebo-controlled, double-blind, ...
Idoyaga Juliana J Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, New York, USA. - - 2013
Harnessing DCs for immunotherapies in vivo requires the elucidation of the physiological role of distinct DC populations. Migratory DCs traffic from peripheral tissues to draining lymph nodes charged with tissue self antigens. We hypothesized that these DC populations have a specialized role in the maintenance of peripheral tolerance, specifically, to ...
Siedlinski Mateusz M Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA. - - 2013
Cigarette smoking is the major environmental risk factor for chronic obstructive pulmonary disease (COPD). Genome-wide association studies have provided compelling associations for three loci with COPD. In this study, we aimed to estimate direct, i.e., independent from smoking, and indirect effects of those loci on COPD development using mediation analysis. ...
Jackson D D Marine Environment and Food Safety Services, Marine Institute, Rinville, Oranmore, Co. Galway, Ireland. - - 2013
Sea lice infestation as a source of marine mortality of outwardly migrating Atlantic salmon smolts has been investigated by treating groups of ranched salmon, prior to release, with a prophylactic sea lice treatment conferring protection from sea lice infestation. A number of studies have been carried out in Ireland using ...
Bougas B B Département de Biologie, Institut de Biologie Intégrative et des Systèmes IBIS, Université Laval, Québec, Québec, Canada G1V 0A6. - - 2013
Parental effects represent an important source of variation in offspring phenotypes. Depending on the specific mechanisms involved, parental effects may be caused to different degrees by either the maternal or the paternal parent, and these effects may in turn act at different stages of development. To detect parental effects acting ...
Dai C C Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, - - 2013
Multilocus data from the different genomes are essential to understand the phylogeographic history of species, particularly when a species has the male-biased dispersal pattern. Although Black-throated tits (Aegithalos concinnus) are socially monogamous and cooperatively breeding birds, limited observational data suggested that males may have the ability of long-distance dispersal. We ...
Ahmedani B K BK Center for Health Policy and Health Services Research, Henry Ford Health System, Detroit, MI 48202, USA. - - 2013
In this global study we sought to estimate the degree to which a family member might feel embarrassed when a close relative is suffering from an alcohol, drug, or mental health condition (ADMC) versus a general medical condition (GMC). To date, most studies have considered embarrassment and stigma in society ...
Vasilopoulos Terrie T Department of Psychiatry & Behavioral Neuroscience, University of Chicago, 5841 S. Maryland Avenue, MC 3077 CNPRU, Chicago, IL 60637, USA. - - 2013
We examined shared and distinct genetic influences among standard measures of pulmonary functions: ratio of forced expiratory volume at 1 s to forced vital capacity (FEV1/FVC) and percent predicted values for forced expiratory volume at 1 s (FEV1%p), forced expiratory flow (FEFmax%p), and maximal voluntary ventilation (MVV%p) in 978-1,048 middle-aged ...
Al-Marrawi Mhd Y MY Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH, - - 2013
There are many active drugs to treat metastatic renal cell carcinoma (mRCC) patients who progress through their first-line vascular endothelial growth factor (VEGF) inhibitor. Many clinicians choose a second-line VEGF inhibitor based on the type of response to first-line VEGF inhibitor, without data supporting this practice. This study was conducted ...
Wiersum Andrew D - - 2013
A high-throughput gas adsorption apparatus is presented for the evaluation of adsorbents of interest in gas storage and separation applications. This instrument is capable of measuring complete adsorption isotherms up to 40 bar on six samples in parallel using as little as 60 mg of material. Multiple adsorption cycles can ...
Vlachopoulos Charalambos V - - 2013
BACKGROUND: =0.006).Conclusions-ED is associated with increased risk of CV events and all-cause mortality. RR is higher at younger ages, in intermediate-risk groups, and when a questionnaire is used instead of a single question.
Kim Young-Kyoung - - 2013
3-Hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) catalyzes the rate-limiting step in the mevalonate pathway. To elucidate the functions of HMGR in triterpene biosynthesis, Platycodon grandiflorum was transformed with a construct expressing Panax ginseng HMGR (PgHMGR). We used PCR analysis to select transformed hairy root lines and selected 6 lines for further investigation. ...
Hardimon Michael O - - 2013
Confusions about the place of race in medicine result in part from a failure to recognize the plurality of race concepts. Recognition that the ordinary concept of race is not identical to the racialist concept of race makes it possible to ask whether there might be a legitimate place for ...
Beauregard Eric - - 2013
The aim of this study was to test whether there is a relationship between situational and modus operandi characteristics and criminal mobility during the sexual assault event. Data collected from both police files and semistructured interviews with 72 serial sex offenders who have committed 361 sexual assaults have been used. ...
Zhang Yang - - 2013
Tb(3+), Tm(3+), and Dy(3+)-activated SrY(2)O(4) phosphors have been prepared via Pechini-type sol-gel method. X-Ray diffraction (XRD), field-emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), photoluminescence (PL) and lifetimes, as well as cathodoluminescence (CL) spectra were used to characterize the samples. Under low-voltage electron beam excitation, the Tb(3+)-doped samples show ...
Hsu Hong-Yuan - - 2013
Background. The long-term evolution and outcomes of hepatitis B surface gene mutant (HBSGM) infection in immunized children remain unclear.Methods. Ninety-five HBsAg-positive children with postnatal immunoprophylaxis failure, aged 0.5-18.4 (mean 5.8) years, were prospectively followed for 1-22.8 (mean 8.5) years. Clinical, serologic and virologic features were compared between untreated, HBeAg-positve children carrying HBSGM ...
Avula Bharathi - - 2013
Terminalia species are a rich source of tannins. Many preparations of these species are used in traditional medicine and have many different ethnobotanical applications. A simple UHPLC method was developed for the simultaneous analysis of such hydrolysable tannins and triterpene saponins from the fruit rinds of different species of Terminalia ...
Wang Huan - - 2013
This study demonstrates a potential signaling pathway of CO 2-dependent stimulation in lateral root (LR) formation. Elevated CO 2 increases production of nitric oxide (NO), which subsequently stimulates the generation of cytosolic Ca ( 2+) concentration by activating plasma membrane and/or intracellular Ca ( 2+) -permeable channels. Meanwhile, nitric oxide ...
St-Cœur Patrick-Denis - - 2013
A series of PF-8380 analogs, a recently developed autotaxin inhibitor, was explored. Inhibition of autotaxin by these analogs, as well as by all PF-8380 synthetic intermediates, shows the importance of meta-dichlorobenzyl and benzo[d]oxazol-2(3H)-one fragments. However, analogs 8 and 9, bearing only the benzo[d]oxazol-2(3H)-one moiety, are more cytotoxic on the LN229 ...
Parks Joel H - - 2013
Abstract Recent time resolved lifetime measurements studied the quenching of the fluorescence emitted by a dye covalently bound to the desolvated peptide Dye-Pro4-Arg+-Trp. This peptide sequence was chosen for study since intramolecular interactions constrain all large-scale fluctuations except for those of the interacting dye and Trp sidechain. It was shown ...
Wu Yang - - 2013
A uniform Fe3O4 sheath is magnetron sputtered onto aligned carbon nanotube (CNT) scaffolds which are directly drawn from CNT arrays. The Fe3O4-CNT composite electrode, with the size of Fe3O4 confined to 5-7 nm, exhibits a high reversible capacity over 800 mAh g-1 based on the total electrode mass, remarkable capacity ...
Liang Yingjian - - 2013
The increasing incidence of hepatocellular carcinoma (HCC) is of great concern not only in the United States but throughout the world. Although sorafenib, a multikinase inhibitor with antiangiogenic and antiproliferative effects, currently sets the new standard for advanced HCC, tumor response rates are usually quite low. An understanding of the ...
Pinto Luiz Fernando - - 2013
NMR is a powerful tool to study the dynamics of dendrimers. By analogy to linear polymers, shorter T1 relaxation times have been traditionally associated to less mobile nuclei and hence, dendrimers described with reduced local motions either at the core or the periphery. Herein we report a NMR relaxation study ...
Fekjaer Hans Olav - - 2013
A conspicuous fact is that light or moderate drinking apparently prevent such a large number of unrelated diseases. It is even more striking that beneficial effects for the different diseases all seem to peak at approximately the same consumption level. For almost all the diseases, there is a remarkable absence ...
Tiitinen Sanni - - 2013
Early support has been acknowledged to be needed in the phase of transition to parenthood, and increasing knowledge is available on the factors enhancing this transition. The issue is to translate the knowledge into practices of preventive care. In this article, our aim is to map out recent research on ...
Mullen Brian R - - 2013
Genetic and environmental factors are both likely to contribute to neurodevelopmental disorders, including autism spectrum disorders. In this study, we examined the combinatorial effect of two factors thought to be involved in autism - reduction in the expression of the extracellular matrix protein reelin and prenatal exposure to an organophosphate ...
Newman Christy E - - 2013
Objectives. Cancer is the second biggest killer of Aboriginal Australians. For some cancers, the mortality rate is more than three times higher in Aboriginal people than for non-Aboriginal people. The Aboriginal Patterns of Cancer Care Study explored barriers to and facilitators of cancer diagnosis and treatment among Aboriginal and Torres ...
Choi Yoonjoo - - 2013
The protein universe displays a wealth of therapeutically relevant activities, but T-cell driven immune responses to non-"self" biological agents present a major impediment to harnessing the full diversity of these molecular functions. Mutagenic T-cell epitope deletion seeks to mitigate the immune response, but can typically address only a small number ...
López-Berges Manuel S - - 2013
Soilborne fungal pathogens are highly persistent and provoke important crop losses. During saprophytic and infectious stages in the soil, these organisms face situations of nutrient limitation and lack of essential elements, such as iron. We investigated the role of the bZIP transcription factor HapX as a central regulator of iron ...
Kawashima Yusuke - - 2013
LC-ESI/MS/MS-based shotgun proteomics is currently the most commonly used approach for the identification and quantification of proteins in large scale studies of biomarker discovery. In the past several years, the shotgun proteomics technologies have been refined toward further enhancement of proteome coverage. In the complex series of protocols involved in shotgun ...
George Chandramohan - - 2013
We report a colloidal synthesis of Au0.80Pd0.20-FexOy dumbbell NCs derived from Au0.75Pd0.25 NCs by metal oxide overgrowth. We compared the catalytic activity of the two types of NCs in the CO oxidation reaction (CO+1/2O2ï‚®CO2), after they had been dispersed on an alumina nanopowder support. In both cases, the surface active ...
Carpiniello B - - 2013
Background: The Authors sought to evaluate current prevalence of mental disorders in patients affected by metabolic syndrome compared with patients affected by central obesity alone. Methods: 186 (63.5%) patients affected by central obesity and 107 (36.5%) affected by metabolic syndrome according to ICF criteria were interviewed by means of SCID ...
Hoffman-Censits Jeannie - - 2013
Enzalutamide (MDV3100, Xtandi, Medivation\Astellas) is an oral inhibitor of androgen receptor signaling which blocks androgen-receptor interaction; inhibits translocation of the androgen receptor to the nucleus; impairs androgen receptor binding to DNA; and inhibits co-activator recruitment and receptor mediated DNA transcription. In a Phase III randomized study comparing Enzalutamide to placebo ...
Lun Yu - - 2013
ObjectiveHashimoto's thyroiditis (HT) has been associated with an elevated risk of papillary thyroid cancer (PTC). To investigate the possible influence of HT on the prognosis of PTC patients, we assessed the related clinical factors linking these conditions, especially serum thyroid-stimulating hormone (TSH) concentration.Study DesignCase-control study.SettingThe First Hospital of China Medical ...
Michou Emilia - - 2013
BACKGROUND: . Several stimulation parameters can influence the neurophysiological and behavioral effects of paired associative stimulation (PAS), a neurostimulation paradigm that repeatedly pairs a peripheral electrical with a central cortical (transcranial magnetic stimulation [TMS]) stimulus. This also appears to be the case when PAS is applied to the pharyngeal motor ...
Soriano Aileen - - 2013
Diencephalic storms or paroxysmal sympathetic storms are characterized by episodic hyperhidrosis, hypertension, tachypnea, tachycardia, and abnormal posturing. These have been reported to occur in patients with hydrocephalus, intracranial tumors, and hypoxic, ischemic, or traumatic brain injury. They can be easily misdiagnosed as seizures, uncontrolled pheochromocytoma, drug withdrawal, thyroid storm, hypertensive ...
Leese G P - - 2013
AIMS: To determine whether geography and/or social deprivation influences the occurrence of foot ulcers or amputations in patients with diabetes METHODS: A population-based cohort of people with diabetes (n = 15 983) were identified between 2004 and 2006. Community and hospital data on diabetes care, podiatry care and onset of ulceration and amputation ...
Czarnecki Olaf - - 2013
The formation of 5-aminolevulinic acid (ALA) at the beginning of the pathway is the rate limiting step of tetrapyrrole biosynthesis and target of multiple timely and spatially organized control mechanisms. Recent discovery of a glutamyl-tRNA reductase-binding protein (GluTRBP), reveals a new insight in the topology of regulation of plant ALA ...
Huang Liming - - 2013
Germline mutations in genes that cause hereditary syndromes are highly predisposed to familial pancreatic cancer. However, genetic susceptibility to sporadic pancreatic cancer is largely uncovered. We conducted a two-stage association study on pancreatic cancer that included 981 cases and 1,991 controls in the first stage followed by a second stage ...
Begriche Karima - - 2013
The worldwide epidemic of obesity and insulin resistance favours nonalcoholic fatty liver disease (NAFLD). Insulin resistance (IR) in the adipose tissue increases lipolysis and the entry of non-esterified fatty acids (NEFAs) in the liver, whereas IR-associated hyperinsulinemia promotes hepatic de novo lipogenesis. However, several hormonal and metabolic adaptations are set ...
Ambrose Christopher S - - 2013
The Vaccines for Children (VFC) program distributes one half of all vaccines administered to US children. Compared with commercial vaccine distribution, VFC distribution is more complex. This prospective observational study compares the delivery and administration of VFC versus non-VFC influenza vaccine in US pediatricians' offices across 3 influenza seasons and ...
Chalkley Robert J - - 2013
To address problems with estimating the reliability of proteomic search engine results from mass spectrometry fragmentation data the use of target-decoy database searching has become the de facto approach for estimating a false discovery rate. Several articles have been written about the effects of different ways of creating the decoy ...
Wang Pengcheng - - 2013
Reactive oxygen species (ROS) have been characterized as both important signaling molecules and universal stressors that mediate many developmental and physiological responses. So far, details of the transcriptional mechanism of ROS-responsive genes are still largely unknown. In the study reported herein, we identified seven potential ROS-responsive cis-acting elements (ROSEs) from ...
Li Baohai - - 2013
Plastid retrograde signaling (chloroplast to nucleus) has been proposed to play an important role in the acclimation of plant function to environmental stress. Although several pathways and molecular components, as well as some signals, have been identified in recent years, our understanding of the communication between plastid and nucleus under ...
De Tullio Mario - - 2013
The functional role of ascorbate oxidase (AO; EC 1.10.3.3) has never been fully explained so far, due to the difficulties in understanding the presence of an enzyme specifically oxidizing ascorbate with no obvious advantage, and the apparent disadvantage of lowering plant stress resistance as a consequence of ascorbate consumption. Here ...
Yavuz Oguzhan - - 2013
In this study, 70 Wistar rats were randomly divided into seven equal groups (six experimental and one control), which consisted of animals belonging to both sexes. Different combinations of insecticides were administered daily to the experimental groups (group 1: cypermethrin + piperonyl butoxide (PBO); group 2: alphacypermethrin + PBO; group ...
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