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Syed Deeba N DN Department of Dermatology University of Wisconsin, Medical Sciences Center, Madison WI-53706, - - 2013
Plants have long been providing mankind with remedies of different ailments. Flavonoids, a family of naturally occurring polyphenolic compounds are ubiquitous in plants. Development of polyphenol-based drugs has not attracted much attention by researchers and drug companies. Therefore, despite extensive studies on polyphenols, this vast group of compounds is underrepresented ...
Huang Yan-Hao YH Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan 106, Republic of - - 2013
This study aims to evaluate whether the distribution of vessels inside and adjacent to tumor region at three-dimensional (3-D) power Doppler ultrasonography (US) can be used for the differentiation of benign and malignant breast tumors. 3-D power Doppler US images of 113 solid breast masses (60 benign and 53 malignant) ...
Gonzales Kalynda Kari KK Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, - - 2013
Striatal cholinergic interneurons (ChIs) are involved in reward-dependent learning and the regulation of attention. The activity of these neurons is modulated by intrinsic and extrinsic γ-aminobutyric acid (GABA)ergic and glutamatergic afferents, but the source and relative prevalence of these diverse regulatory inputs remain to be characterized. To address this issue, ...
De Sevilla Müller Luis Pérez LP Department of Neurobiology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California 90095, USA. - - 2013
High-voltage activated Ca channels participate in multiple cellular functions, including transmitter release, excitation, and gene transcription. Ca channels are heteromeric proteins consisting of a pore-forming α(1) subunit and auxiliary α(2)δ and β subunits. Although there are reports of α(2)δ(4) subunit mRNA in the mouse retina and localization of the α(2)δ(4) ...
Unal Gunes G Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey 07102, - - 2013
The perirhinal cortex plays a critical role in recognition and associative memory. However, the network properties that support perirhinal contributions to memory are unclear. To shed light on this question, we compared the synaptic articulation of short- and long-range inputs from the perirhinal cortex or temporal neocortex with perirhinal neurons ...
Lloyd Gavin Rhys GR Biophotonics Research Group, Gloucestershire Royal Hospital, Great Western Road, Gloucester, GL1 3NN, - - 2013
The potential use of Raman spectroscopy (RS) for the detection of malignancy within lymph nodes of the head and neck was evaluated. RS measures the presence of biomolecules by the inelastic scattering of light within cells and tissues. This can be performed in vivo in real-time. 103 lymph nodes were ...
Craig Kimberly S KS University of Michigan, 530 Church Street, Ann Arbor, MI 48109, USA. - - 2013
Proactive interference occurs when information from the past disrupts current processing and is a major source of confusion and errors in short-term memory (STM; Wickens, Born, & Allen, Journal of Verbal Learning and Verbal Behavior, 2:440-445, 1963). The present investigation examines potential boundary conditions for interference, testing the hypothesis that ...
Schmid Douglas I DI Division of Vascular Surgery, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, - - 2013
Stimulated endothelial cells (EC) assume an activated phenotype with pro-inflammatory and prothrombotic features, requiring new gene and protein expression. New protein synthesis in activated EC is largely regulated by transcriptional events controlled by a variety of transcription factors. However, post-transcriptional control of gene expression also influences phenotype and allows the ...
Dimitrov Eugene L EL Section on Fundamental Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892, - - 2013
The noradrenergic locus coeruleus (LC) regulates arousal, memory, sympathetic nervous system activity, and pain. Forebrain projections to LC have been characterized in rat, cat, and primates, but not systematically in mouse. We surveyed mouse forebrain LC-projecting neurons by examining retrogradely labeled cells following LC iontophoresis of Fluoro-Gold and anterograde LC ...
Kubitza Dagmar D Clinical Pharmacology, Bayer Pharma AG, Wuppertal, Germany. - - 2013
This study investigated the effects of hepatic impairment on the pharmacokinetics and pharmacodynamics of a single dose of rivaroxaban (10 mg), an oral, direct Factor Xa inhibitor. This single centre, non-randomized, non-blinded study included subjects with mild (n = 8) or moderate hepatic impairment (n = 8), according to the Child-Pugh ...
Terstappen Karin - - 2013
Spectrophotometric intracutaneous analysis (SIAscopy) is an imaging technique developed for diagnostics of pigmented skin lesions. By image analysis, the displayed images indicate the potential distribution and position of melanin, blood, and collagen within the lesion. A topographic comparison was performed between SIAscopic findings and histopathology. In total, 60 patients with ...
Levin L Scott LS University of Pennsylvania Health System, Hospital of University of Pennsylvania, 2 Silverstein Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA. - - 2013
The key to successfully aligning hospitals and physicians is financial integration and joint incentives for academic, quality, and clinical productivity. Many physician practices and health systems are moving toward closer integration, but mainly through consolidation and employment strategies. We describe a fully integrated physician and hospital relationship including an overview ...
Arnold Kathleen M KM Department of Psychology, CB1125, Washington University in St. Louis, St. Louis, MO 63130-4899, USA. - - 2013
Testing, or retrieval practice, has become a central topic in memory research. One potentially important effect of retrieval practice has received little attention, however: It may enhance, or potentiate, subsequent learning. We introduce a paradigm that can measure the indirect, potentiating effect of free recall tests on subsequent learning, and ...
Ellis Jason S JS Department of Medicine, University of Missouri School of Medicine, Columbia, MO, - - 2013
Approximately 80% of female wild-type non-obese diabetic (WT NOD) mice spontaneously develop diabetes, whereas B-cell-deficient (B(-/-)) NOD mice are resistant to diabetes. B(-/-) mice are also resistant to other spontaneous and experimentally induced autoimmune diseases, including arthritis, systemic lupus erythematosus, Sjögren syndrome and thyroiditis. Under normal conditions, activation of self-reactive ...
Dugas Véronique V Research Centre, Maisonneuve-Rosemont Hospital, Montreal, Quebec, - - 2013
Immunoregulatory CD4(-)  CD8(-) (double-negative; DN) T cells exhibit a unique antigen-specific mode of suppression, yet the ontogeny of DN T cells remains enigmatic. We have recently shown that 3A9 T-cell receptor (TCR) transgenic mice bear a high proportion of immunoregulatory 3A9 DN T cells, facilitating their study. The 3A9 TCR ...
Strandbygaard Jeanett J Department of OBGYN, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark. - - 2013
To investigate the impact of instructor feedback versus no instructor feedback when training a complex operational task on a laparoscopic virtual reality simulator. : Simulators are now widely accepted as a training tool, but there is insufficient knowledge about how much feedback is necessary, which is useful for sustainable implementation. ...
Bini Jason J Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY 10029, - - 2013
The application of attenuation correction for combined magnetic resonance/positron emission tomography (MR/PET) systems is still a major challenge for accurate quantitative PET. Computed tomographic attenuation correction (CTAC) is the current clinical standard for PET/computed tomographic (CT) scans. Magnetic resonance, unlike CT, has no direct information about photon attenuation but, rather, ...
Pando Maria A MA Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Piso 11, C1121ABG, Buenos Aires, Argentina. - - 2013
Five hundred men who have sex with men (MSM), recruited through respondent driven sampling in Buenos Aires, Argentina, were interviewed in order to assess knowledge and beliefs about HIV infection. The mean proportion of HIV correct knowledge answers was 62 %; however participants whose sexual partners in the prior year ...
Bogart Laura M LM Department of Pediatrics, Harvard Medical School, Boston, MA, USA. - - 2013
We conducted the first study to examine health correlates of discrimination due to race/ethnicity, HIV-status, and sexual orientation among 348 HIV-positive Black (n = 181) and Latino (n = 167) men who have sex with men. Participants completed audio computer-assisted self-interviews. In multivariate analyses, Black participants who experienced greater racial ...
Smith Kimberly A KA Robert Wood Johnson Foundation Clinical Scholars Program Divisions of General Internal Medicine, University of Michigan, Ann Arbor, MI 48109-5604, - - 2013
Performance measures are widely used to profile primary care physicians (PCPs) but their reliability is often limited by small sample sizes. We evaluated the reliability of individual PCP profiles and whether they can be improved by combining measures into composites or by profiling practice groups. We performed a cross-sectional analysis ...
Ro Cynthia C Division of Endocrinology, Diabetes, and Metabolism, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Becker 131, Los Angeles, CA 90048, - - 2013
Osteoporosis related fractures contribute to morbidity and mortality in U.S. patients, placing a heavy financial burden on society. Randomized clinical trials involving over 30,000 subjects have established bisphosphonates' efficacy in reducing the incidence of fragility fractures. However, as bisphosphonates are retained for years in the skeleton, reports of adverse events ...
Austin Peter C - - 2013
Hospital report cards, in which outcomes following the provision of medical or surgical care are compared across health care providers, are being published with increasing frequency. Essential to the production of these reports is risk-adjustment, which allows investigators to account for differences in the distribution of patient illness severity across ...
Parikh Hemang H Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, - - 2013
The objective of this study was to fine-map common pancreatic cancer susceptibility regions. We conducted targeted Roche-454 resequencing across 428 kb in 3 genomic regions identified in genome-wide association studies (GWAS) of pancreatic cancer, on chromosomes 1q32.1, 5p15.33, and 13q22.1. An analytical pipeline for calling genotypes was developed using HapMap ...
Itoi Eiji - - 2013
Bone loss is commonly observed in shoulders with anterior instability. The Latarjet procedure is commonly performed when a glenoid bony defect exists that is greater than 25 % of the glenoid width or when the risk of recurrent instability is higher (i.e., collision-sport athletes). Hill-Sachs lesions need to be assessed as ...
Brown Jennifer R JR Harvard Medical School and Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA. - - 2013
Ibrutinib is a potent covalent kinase inhibitor that targets BTK. BTK, or Bruton's tyrosine kinase, is an obvious target for therapy of B cell diseases because inactivating mutations lead to B cell aplasia in humans and the disease X-linked agammaglobulinemia. Ibrutinib has modest cytotoxicity against CLL cells in vitro but ...
Goswami Lalit N LN International Institute of Nano and Molecular Medicine, School of Medicine, University of Missouri, 1514 Research Park Drive, Columbia, Missouri 65211-3450, - - 2013
Herein we describe the sequential synthesis of a variety of azide-alkyne click chemistry-compatible heterobifunctional oligo(ethylene glycol) (OEG) linkers for bioconjugation chemistry applications. Synthesis of these bioorthogonal linkers was accomplished through desymmetrization of OEGs by conversion of one of the hydroxyl groups to either an alkyne or azido functionality. The remaining ...
Wu Jie - - 2013
Th17 responses have been suggested to participate in the pathogenesis of acute allograft rejection. RORγt is the master transcription factor that controls Th17 cell differentiation and expansion. However, little is known about the effect that antagonizing RORγt activity may have on acute cardiac allograft rejection. A model of heterotopic murine ...
Belavic Jennifer M - - 2013
Each year, the FDA approves many pharmaceuticals and products designed to treat or improve a patient's condition. The following is a sampling of some of the most important drugs approved in 2012 that specifically apply to nurse practitioner practice.
Wolken Gregory G GG Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, - - 2013
Mitochondria are heterogeneous organelles involved in energy production, metabolism, and cellular signaling that oftentimes are isolated from cells for chemical characterization (e.g., proteomic analysis). The chemical composition of the mitochondrial outer membrane is one of the factors defining the mitochondrial isoelectric point (pI), which is a property useful for the ...
Ozcan Sureyya S Department of Chemistry, University of California, Davis, Davis, California 95616, United - - 2013
O-Glycans in saliva and tear isolated from patients suffering from ocular rosacea, a form of inflammatory ocular surface disease, were profiled, and their structures were elucidated using high resolution mass spectrometry. We have previously shown that certain structures, particularly sulfated oligosaccharides, increased in the tear and saliva of rosacea patients. ...
Chan An-Wen AW Women’s College Research Institute, Women’s College Hospital, University of Toronto, 790 Bay Street, Toronto, Ontario M5G 1N8, Canada. - - 2013
The protocol of a clinical trial serves as the foundation for study planning, conduct, reporting, and appraisal. However, trial protocols and existing protocol guidelines vary greatly in content and quality. This article describes the systematic development and scope of SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) 2013, a guideline ...
Banin Luciana Burgugi - - 2013
Background:  Few studies have investigated potential differences between the opinions of educators and undergraduates regarding spirituality in patient care. Understanding these differences, could lead to better strategies for educational proposes. Purpose:  To compare the opinions of medical teachers (MTs) and medical students (MSs) regarding spirituality training in a Brazilian medical ...
Kastrup M - - 2013
The development and implementation of practice guidelines might be an important tool to evaluate the different practices and to consider different local strategies. A postal questionnaire with 37 questions was sent to the leading physicians of 80 intensive care units in Germany, treating patients after cardiothoracic surgery. The survey covered ...
Ray S - - 2013
To study cell cycle delay and metaphase arresting activity of leaf aqueous extract of Clerodendrum viscosum Vent. (LAECV) in root apical meristems and mouse bone marrow cells. Cell cycle delay and metaphase arresting activities of LAECV were analysed, in root apical meristems of onion and wheat, and in mouse bone ...
Kim Beom K - - 2013
Monitoring fibrosis is mandatory for detailed prognostification in patients with chronic liver disease. We developed optimized cut-offs for liver stiffness (LS) values, based on the histological subclassification of cirrhosis, and investigated whether early on-treatment changes in LS values can predict long-term prognosis in patients with hepatitis B virus (HBV)-related advanced ...
Ampofo Krow - - 2013
To provide an update and overview of infectious disease issues in children of international adoption. International adoption by US families has decreased since 2004. Countries from where children are adopted have changed by 2011, with Ethiopia the second largest contributor of international adoptees after China. Since 2003, international adoptees are ...
Chisci E - - 2013
Successful hybrid treatment of the total symptomatic acute occlusion of a common carotid artery (CCA) concomitant to ipsilateral internal carotid artery (ICA) stenosis has only been described once in the literature to date. The management of this anatomic distribution of disease can be a challenge both to plan and perform. ...
Abendroth Martin - - 2013
Background:  As many medical schools focus on student-centred learning strategies, e-learning provides a useful approach to foster clinical decision-making skills in a case-based way. We developed an e-learning module based on real patient cases for final-year students as a self-directed studying tool. Methods:  Ten patient cases were developed from patients ...
Li Z - - 2013
Diabetic nephropathy is a major complication of diabetes and a frequent cause of end-stage renal disease and recent studies suggest that podocyte damage may play a role in the pathogenesis of this. At early onset of diabetic nephropathy there is podocyte drop-out, which is thought to provoke glomerular albuminuria and ...
Jayia P - - 2013
Endovascular aneurysm repair (EVAR) is widely accepted as a safe technique for treatment of aortic diseases since the concept was first pioneered by Volodos in 1986 and Parodi in 1991. Numerous registries have shown that this minimally invasive technique is associated with lower mortality when compared to open surgery in ...
Feenaughty Lynda - - 2013
This preliminary study investigated how cognitive-linguistic status in multiple sclerosis (MS) is reflected in two speech tasks (i.e. oral reading, narrative) that differ in cognitive-linguistic demand. Twenty individuals with MS were selected to comprise High and Low performance groups based on clinical tests of executive function and information processing speed ...
Rosenkranz M - - 2013
Carotid artery stenting is associated with the risk of periprocedural stroke. Moreover, modern magnetic resonance (MR) imaging techniques have found high rates of clinically silent ischemic brain lesions on post-treatment diffusion-weighted MR imaging (DWI) scans. The clinical significance of procedure-related DWI lesions, however, is still a matter of debate. This ...
Yim Hyung Joon - - 2013
Management of lamivudine-resistant chronic hepatitis B (CHB) remains challenging, as inappropriate choice of treatment may cause multidrug resistance. Until now, randomized trials directly comparing adding adefovir and switching to entecavir monotherapy have not been reported. This multicentre prospective randomized study was designed to compare the efficacy of these two strategies. ...
Kopycinska Justyna - - 2013
Impaired regulation of apoptosis has been suggested to play a role in the pathogenesis of Primary Biliary Cirrhosis (PBC). In this study, we analysed a signalling pathway that comprises the transcription factor FoxO3a and its downstream target Bim, a Bcl-2 interacting mediator of apoptosis. The tissues examined included livers explanted ...
McGeehan John J Departments of Family Community & Rural Medicine and Medicine, The Commonwealth Medical College, Scranton, Pennsylvania, USA. - - 2013
Longitudinal generalist preceptorship experiences early in medical education can have beneficial effects on how students practise the art and science of medicine, regardless of their eventual career choices. We evaluated the first 2 years of implementation of an integrated, regional campus-based, early clinical experience programme, the Community Continuity Program, at ...
Bosiers M - - 2013
The aim of the present article was to report the 12-month results of the Zilver® PTX® Single Arm StudyTASC C/D de novo lesion subgroup. The Zilver PTX Drug-Eluting Peripheral Stent is a self-expanding nitinol stent with a polymer-free paclitaxel coating. This is a prospective, single-arm, multicentre clinical study evaluating the ...
Macdougall Louise - - 2013
Background:  Newly qualified doctors frequently feel unprepared for clinical practice. 'Performing under stress' has been cited as a particular barrier in this transitional period. Conventional views on training using simulation state that it must take place in a controlled environment to benefit learning; however, we attempted to create a high ...
Rodriguez-Galindo Carlos - - 2013
Reduction of child mortality is one of the Millennium Development Goals; as low-income and middle-income countries (LMICs) advance toward the achievement of this goal, initiatives aimed at reducing the burden of noncommunicable diseases, including childhood cancer, need to be developed. Approximately 200 000 children and adolescents are diagnosed with cancer every ...
Julius Justin M JM Division of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston, TX 77230, - - 2013
This study aims to determine factors that may increase the likelihood of adverse drug events (ADEs) in patients with recurrent endometrial cancer treated with pegylated liposomal doxorubicin (PLD) as well as this agent's impact on clinical outcomes. The treatment records of patients with endometrial cancer who received PLD at The ...
Shi Z - - 2013
The legume lectin family, one of the most extensively studied plant lectin families, has received increasing attention for the remarkable anti-tumor activities of its members for binding specific cancer cell surface glycoconjugates. MicroRNAs, a class of small, non-coding RNAs, control translation and stability of mRNAs at post-transcriptional and translational levels. ...
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