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Results 401 - 450 of 2997
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Rizk Elias - - 2013
INTRODUCTION: We have previously argued that the clinical entity of dorsal third ventricular cyst in association with agenesis of the corpus callosum is a developmentally, radiologically, and clinically distinct and separate entity from the dorsal cyst of alobar holoprosencephaly. PATIENTS AND METHODS: Herein, we describe seven patients who underwent treatment ...
Lefler Leanne L - - 2013
Approximately 95% of older women have factors that put them at risk for developing cardiovascular disease, but research indicates many do not perceive themselves to be at risk. We examined older women's perceived risk for coronary heart disease (CHD) and the factors influencing their perceptions. We conducted a descriptive, qualitative ...
Holst J J - - 2013
Recent research has indicated that appetite-regulating hormones from the gut may have therapeutic potential. The incretin hormone, glucagon-like peptide-1 (GLP-1), appears to be involved in both peripheral and central pathways mediating satiation. Several studies have also indicated that GLP-1 levels and responses to meals may be altered in obese subjects. ...
Karmali Kunal N - - 2013
Current practice in the primary prevention of cardiovascular disease (CVD) involves estimation of the short-term (typically 5-10-year) risk of developing CVD. This risk estimation can serve as the prelude to a conversation between physicians and patients about CVD risk and risk-reducing therapies. However, focusing solely on short-term risk directs these ...
Niu Li-Ya - - 2013
We report a turn-on fluorescent sensor based on nitrothiophenolate boron dipyrromethene (BODIPY) derivatives for the discrimination of cystein (Cys) from homocystein (Hcy) and glutathione (GSH). The sensor was applied for detection of Cys in living cells.
Chan T S Y - - 2013
The Sporopachydermia cereana species lives in decaying stems of cactus and is exceptionally rare as a human pathogen. A 57-year-old man with therapy-refractory acute promyelocytic leukaemia developed severe neutropaenia. After about 3 weeks of micafungin used as prophylaxis, he developed high fever, multiple pulmonary nodular infiltrates and a painful leg lesion. ...
Voong Kieran - - 2013
Hepatic vitamin K-dependent proteins (e.g., Factors II, VII, IX and X) form part of the clotting cascade. Factor II (FII)/Prothrombin incorporates 10 Glu residues on the N-terminal region that are γ-carboxylated to Gla residues by the action of γ-glutamyl carboxylase to confer biological activity. Vitamin K is also required for ...
Lyons Heidi H Department of Sociology/Anthropology, Oakland University, Rochester, MI 48309, USA. - - 2013
Casual sex is often associated with the young adult stage in the life course. Most recent research on the prevalence, motives, and consequences of heterosexual casual sex has relied on samples of college students, yet students are only a small and advantaged subset of the young adult population. The current ...
Boscaro Vittorio - - 2013
The "Midichloria clade" is a recently discovered but well-established evolutionary lineage clustering inside the order Rickettsiales (Alphaproteobacteria). Not much is known about the biology of these organisms. The best characterized ones are endocellular symbionts of very different eukaryotic hosts, ranging from arthropods to protists. "Candidatus Midichloria mitochondrii", the most studied ...
Stopa Barbara - - 2013
Congo red dye as well as other eagerly self-assembling organic molecules which form rod-like or ribbon-like supramolecular structures in water solutions, appears to represent a new class of protein ligands with possible wide-ranging medical applications. Such molecules associate with proteins as integral clusters and preferentially penetrate into areas of low ...
Disalvo E Anibal - - 2013
It has been suggested that water in confined regions presents different properties than bulk water, mainly due to the changes in water population species that may be induced by the adjacent walls of different polarities, in terms of hydrogen bonding formation. In this context, it would be expected that lipids ...
Maurer Eva - - 2013
Matriptase-2, a recently identified cell surface protease is the key enzyme of iron homeostasis modulating the expression of the liver peptide hormone hepcidin. Hepatocyte growth factor activator inhibitors type 1 and 2 (HAI-1 and HAI-2) have been shown to inhibit the close homologue, i.e. matriptase. By co-expressing matriptase-2 and the ...
Wong S - - 2013
Objectives:To validate the Screening Tool for the Assessment of Malnutrition in Paediatrics (STAMP) in paediatric spinal cord injuries (SCIs) patients admitted to the tertiary SCI centre.Methods:children's baseline clinical data, anthropometric measurements and STAMP score were assessed on admission. The validity of STAMP was assessed by (i) comparison with a full ...
Han Kyung Su - - 2013
AIM: Background adenoma (BGA) is defined as benign adenomatous tissue contiguous to resected carcinomas, and the absence of BGA in the tumour is considered a histologic criterion of de novo cancers. The present study aimed to identify the clinicopathologic characteristics of T1 colorectal cancer without BGA. METHOD: A retrospective review ...
Ní Chróinín Danielle - - 2013
We conducted a cross-sectional study of the understanding on osteoporosis amongst community-dwelling geriatric patients. Patient understanding on the pathology, risk factors and its complications was suboptimal, but better amongst women and persons with diagnosed osteoporosis. Improving patient osteoporosis education may lead to improved compliance with preventive and therapeutic measures. Osteoporosis ...
Toma Renata Luri - - 2013
Aging process involves several structural changes in muscle tissue which lead to decrease in musculoskeletal function. One of the most common physiological modifications is the increase in fatigability in elderly people, which leads to inability to maintain strength and motor control. In this context, low-level laser therapy (LLLT) has demonstrated ...
Szabados Hajnalka - - 2013
Desmosomal transmembrane glycoproteins desmogleins (Dsg) 1 and 3 are targets of life-threatening autoimmune blistering disorders such as Pemphigus vulgaris (PV) and Pemphigus foliaceus (PF). In these diseases, pemphigus autoantibodies are produced against Dsg1 and Dsg3 proteins. The autoantibodies bind to these transmembrane elements leading to a loss of desmosomal cell-cell ...
Schlapbach Luregn J - - 2013
PURPOSE: Early-onset sepsis (EOS) is one of the main causes for the admission of newborns to the neonatal intensive care unit. However, traditional infection markers are poor diagnostic markers of EOS. Pancreatic stone protein (PSP) is a promising sepsis marker in adults. The aim of this study was to investigate ...
Schweigert Michael - - 2013
Oesophageal carcinoma is one of the most virulent malignant diseases and a major cause of cancer-related deaths worldwide. Diagnosis and accuracy of pretreatment staging have substantially improved throughout the past three decades. Therapy is challenging and the optimal approach is still debated. Oesophagectomy is considered to be the procedure of ...
Scheen André J - - 2013
Dipeptidyl peptidase 4 (DPP-4) inhibitors (commonly referred to as gliptins) are a novel class of oral antihyperglycaemic agents with demonstrated efficacy in the treatment of type 2 diabetes mellitus (T2DM). Preclinical data and mechanistic studies have indicated a possible beneficial action on blood vessels and the heart, via both glucagon-like ...
Sharrad Dale F - - 2013
Parkinson's disease is a neurodegenerative disorder characterized by Lewy bodies and neurites composed mainly of the presynaptic protein, α-synuclein. Frequently, Lewy bodies and neurites are identified in the gut of Parkinson's disease patients and may underlie associated gastrointestinal dysfunctions. We recently reported selective expression of α-synuclein in the axons of ...
Perraud Olivier - - 2013
Efficient alkane C-H bond oxidation was achieved using a newly designed Cu(ii)-hemicryptophane complex. Protection of the copper site in the inner cavity of the host leads to enhanced yields and allows discriminating cyclohexane from cyclooctane or adamantane in competitive experiments.
Teodorczyk Urszula - - 2013
CHEK2 is a tumor suppressor gene whose functions are central to the induction of cell cycle arrest and apoptosis following DNA damage. Mutations in CHEK2 have been associated with cancers at many sites, including breast and prostate cancers, but the relationship between CHEK2 and gastric cancer has not been extensively ...
Dai Baozhen - - 2013
This study examined the regional inequity in the New Cooperative Medical Scheme (NCMS) financing in Jiangsu, China. Counties were classified into three categories according to socio-economic development level: South Jiangsu, Middle Jiangsu and North Jiangsu. Five counties (Changshu, Danyang, Gaoyou, Jiangyan and Ganyu) were selected on the basis of the ...
Aguilera Dolly D Aflac Cancer & Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, 5455 Meridian Mark Rd., NE, Suite 400, Atlanta, GA 30342, - - 2013
Chemotherapy for relapsed medulloblastoma has been inadequate, and most patients succumb to disease. We retrospectively reviewed nine cases of relapsed medulloblastoma treated with bevacizumab, irinotecan, ± temozolomide. Patients received one to three prior therapeutic regimens. Five patients received 10 mg/kg bevacizumab and 125-150 mg/m(2) irinotecan IV every 2 weeks, with temozolomide, ...
Pang Judy C - - 2013
OBJECTIVE: Endoscopic ultrasound-guided fine-needle aspiration and bile duct brushings are utilized in the cytologic evaluation of solid and cystic pancreaticobiliary tract lesions. We sought to determine the diagnostic accuracy of cytology. METHODS: Five hundred seventy-nine pancreatic resections with 727 corresponding cytology specimens were identified from 1997 to 2012. Histologic diagnoses ...
Quigley Eamonn M M - - 2013
GERD and functional dyspepsia are the two most prevalent upper gastrointestinal disorders. Gastro-oesophageal reflux is most commonly diagnosed using the cardinal symptoms of heartburn and regurgitation. Patients might also be diagnosed using a questionnaire, after empiric treatment with an acid suppressant, after upper endoscopy or by pH testing. Functional dyspepsia ...
Schvey N A - - 2013
Objective:To investigate the influence of a defendant's weight on simulated jurors' perceptions of guilt.Design and methods:Participants were 471 lean and overweight adults (mean body mass index: 25.34±5.91) who read a vignette describing a case of check fraud while viewing one of four images of the alleged defendant (a lean male, ...
Kang Jung Won - - 2013
Platelets play a critical role in pathogenesis of cardiovascular disorders and strokes. The inhibition of platelet function is beneficial for the treatment and prevention of these diseases. In this study, we investigated the anti-platelet activity of erythro-(7S,8R)-7-acetoxy-3,4,3`,5`-tetramethoxy-8-O-4`-neolignan (EATN), a neolignan isolated from Myristica fragrans, using human platelets. EATN preferentially inhibited ...
Wang Lili - - 2013
New Au@SnO(2) yolk-shell nanospheres have been successfully synthesized by using Au@SiO(2) nanospheres as sacrificial templates. This process is environmentally friendly and is based on hydrothermal shell-by-shell deposition of polycrystalline SnO(2) on spheriform Au@SiO(2) nanotemplates. Au nanoparticles can be impregnated into the SnO(2) nanospheres and the nanospheres show outer diameters of ...
Wolf M E - - 2013
BACKGROUND AND PURPOSE: The ASCO score has the advantage of allowing a more comprehensive characterization of ischaemic stroke patients and their risk factors, as reflected in different grades of evidence of atherosclerotic changes (A), small vessel disease (S), potential cardiac (C) or other (O) sources. It might also help to ...
Zhang Lei L Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, People's Republic of - - 2013
This paper was designed to assess the value of quality by design (QbD) to improve the manufacturing process understanding of botanical drug products. Ethanol precipitation, a widely used unit operation in the manufacture of botanical drug products was employed to illustrate the use of QbD, taking the process of danshen ...
Welling Lisa L M - - 2013
Recent studies investigating the relationship between self-reported sexual desire and attraction to same- and opposite-sex individuals have found that homosexual men's sexual desire is positively correlated with their self-reported attraction to own-sex individuals only, while homosexual women's sexual desire is positively correlated with their self-reported attraction to both men and ...
Gordon Jason - - 2013
It is unclear as to whether human or long-acting analog insulins represent the most efficient use of health and non-healthcare resources in the management of type 2 diabetes mellitus (T2DM). The aim of this study was to evaluate the value for money relationship associated with the use of these insulins ...
Cerda Mauricio - - 2013
Neural field models have been successfully applied to model diverse brain mechanisms like visual attention, motor control, and memory. Most theoretical and modeling works have focused on the study of the dynamics of such systems under variations in neural connectivity, mainly symmetric connectivity among neurons. However, less attention has been ...
Yang Shuaifeng - - 2013
Abstract It has been suggested that the elastin gene is a candidate gene for the development of intracranial aneurysms (IAs). We investigated the association of single nucleotide polymorphisms (SNPs) in the elastin gene in sporadic subarachnoid hemorrhage (SAH) and in patients with unruptured aneurysms in China. We genotyped 446 (47.9%) ...
Hamzi K - - 2013
Spinal muscular atrophy (SMA) is a severe neuromuscular disease. It is a common cause of infant mortality. Its incidence is estimated at 1 in 10,000. Clinically, age of onset and the symptoms can distinguish four types of SMA. The objective of this study is to make available to clinicians a ...
GoĊ‚embiowska Krystyna - - 2013
The study shows effects of the nonselective adenosine A(1)/A(2A) receptor antagonist caffeine and the selective A(2A) receptor antagonist KW6002 on LPS-induced changes in the extracellular levels of dopamine (DA), glutamate, adenosine, hydroxyl radical, and A(2A) receptor density in the rat striatum. Intrastriatal LPS (10 μg) injection decreased extracellular level of DA ...
Sato Yoshikazu - - 2013
OBJECTIVE: To analyze expectations for sexual life after radical prostatectomy in patients and their partners, and its influence on sexual motivation and bothers in the postoperative period. METHODS: A total of 162 patients who underwent retropubic radical prostatectomy and their partners were evaluated. The patients' sexual function, sexual bother and ...
Zhang Zhen - - 2013
Although the serum sickness-like reaction (SSLR) in children after the administration of cefaclor has long been recognized, the exact mechanism of cefaclor-associated SSLR remains unclear. This study aims to investigate the association between intestinal mucosal permeability and cefaclor-associated SSLR in children. A total of 82 pediatric patients with upper respiratory ...
Briski Elizabeta - - 2013
Nonindigenous species (NIS) cause global biotic homogenization and extinctions, with commercial shipping being a leading vector for spread of aquatic NIS. To reduce transport of NIS by ships, regulations requiring ballast water exchange (BWE) have been implemented by numerous countries. BWE appears to effectively reduce risk for freshwater ports, but ...
Stock Angus - - 2013
Dendritic cells (DCs) have a pivotal role in instructing antigen-specific immune responses, processing and presenting antigens to CD4(+) and CD8(+) T cells and producing factors capable to modulate the quality of T-cell responses. In this review, we will provide an historic overview on the identification of the mechanisms controlling lymphocyte ...
Dong Xueliang - - 2013
For the first time, an organophilic ZIF-71 membrane was prepared and used for pervaporation separation of liquid alcohol-water and dimethyl carbonate-methanol mixtures. The ZIF-71 membrane exhibits good performance in separation of methanol-water and dimethyl carbonate-methanol mixtures.
Prizment Anna E AE Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S. Second Street, Suite 300, Minneapolis, MN 55454-1015, USA. - - 2013
Studies have indicated that diabetes is a risk factor for bladder cancer; however, many failed to adjust for confounding variables. An earlier publication from the Iowa Women's Health Study reported a positive association of baseline diabetes with bladder cancer risk between 1986 and 1998, although the number of cases was ...
Johnston Lisa G - - 2013
For studies using respondent driven sampling (RDS), the current practice of collecting a sample twice as large as that used in simple random sampling (SRS) (i.e. design effect of 2.00) may not be sufficient. This paper provides empirical evidence of sample-to-sample variability in design effects using data from nine studies ...
Tsuji Yuki - - 2013
INTRODUCTION: Double-balloon enteroscopy (DBE) is a useful and feasible modality for evaluating small intestinal lesions, even in children. METHODS: DBE makes it possible to perform biopsy, diagnosis, polypectomy and endoscopic therapies including hemostasis, tattooing and clipping of the small intestinal lesions. However, endoscopic procedures in the small intestines of children ...
Tam Anthony Yiu-Yan - - 2013
Amongst the areas of supramolecular chemistry, low molecular weight gelators (supramolecular gels) have been considered to be one of the most interesting soft and smart materials due to their ability to construct polymeric structures from small molecules through non-covalent interactions. Recently, metal centres have been incorporated into organic-based gelators that ...
Jamieson Nigel B NB West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Alexandra Parade, Glasgow, G31 2ER, UK. - - 2013
The poor overall survival associated with pancreatic ductal adenocarcinoma (PDAC) despite complete resection suggests that occult metastatic disease is present in most at the time of surgery. Resection margin involvement (R1) following resection is an established poor prognostic factor. However, the definition of an R1 resection varies and the impact ...
Prestegard James H JH - - 2013
While chemical shift prediction has played an important role in aspects of protein NMR that include identification of secondary structure, generation of torsion angle constraints for structure determination, and assignment of resonances in spectra of intrinsically disordered proteins, interest has arisen more recently in using it in alternate assignment strategies ...
Chan Cliburn - - 2013
A long-standing paradigm in B cell immunology is that effective somatic hypermutation and affinity maturation require cycling between the dark zone and light zone of the germinal center. The cyclic re-entry hypothesis was first proposed based on considerations of the efficiency of affinity maturation using an ordinary differential equations model ...
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