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Results 301 - 350 of 2997
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Harcourt Brooke E - - 2013
Glycaemic control, reduction of blood pressure using agents that block the renin-angiotensin system and control of dyslipidaemia are the major strategies used in the clinical management of patients with diabetes mellitus. Each of these approaches interrupts a number of pathological pathways, which directly contributes to the vascular complications of diabetes ...
Hsieh Ru - - 2013
ABSTRACT Objective: To investigate possible correlations between the incidence and severity of Bell's palsy and seasonal variations in Taiwan. Methods: We studied data on the incidence of Bell's palsy over a 3-year period in Taiwan. The electroneurographic quotient was used as an index for the severity of nerve involvement. A ...
Romeo José S - - 2013
Publicly available genomic data are a great source of biological knowledge that can be extracted when appropriate data analysis is used. Predicting the biological function of genes is of interest to understand molecular mechanisms of virulence and resistance in pathogens and hosts and is important for drug discovery and disease ...
Suzuki Lisandra Akemi - - 2013
In the present study, an enzyme-linked immunosorbent assay (ELISA) standardized with vesicular fluid of Taenia solium cysticerci was used to screen for IgG (total and subclasses) and IgE antibodies in cerebrospinal fluid (CSF) samples from patients with neurocysticercosis showing intrathecal production of specific IgG antibodies and patients with other neurological ...
Alcaide Benito - - 2013
The divergent gold-catalysed reactivity (C(sp(2))-H versus C(sp(3))-H) of aryloxy-tethered allenes has been uncovered.
Izquierdo Laura - - 2013
Natural orifice transluminal endoscopic surgery designates a surgical procedure that utilizes one or more patent natural orifices of the body with the intention to puncture a hollow viscera in order to enter the abdominal cavity. First carried out at the beginning of the 2000s in experimental models, it can be ...
Li Linxia - - 2013
A selective and sensitive strategy for the fast monitoring of hydroxyl radicals (˙OH) at nanomolar levels has been developed using an electroactive FcHT-functionalized surface amplified by Au nanoparticles and successfully applied to the determination of ˙OH released from live cells.
Cox David J - - 2013
In hippocampal neurons, AMPA receptors (AMPARs) mediate fast excitatory postsynaptic responses at glutamatergic synapses, and are involved in various forms of synaptic plasticity. Dendritic local protein synthesis of selected AMPAR subunit mRNAs is considered an additional mechanism to independently and rapidly control the strength of individual synapses. We have used ...
Zhu Kun-Ju - - 2013
Interleukin 12 (IL-12) is a key player in model systems of autoimmunity. One of the most robust genetic findings is the association of variants in the IL12B gene with psoriasis and psoriatic arthritis (PsA). This study aims to assess whether combined evidence shows the association between IL12B polymorphisms and the ...
Mazbani Edmond - - 2013
Radiation-induced sarcomas represent a rare delayed-late secondary complication of radiation therapy. Radiation-associated sarcomas are associated with a worse overall prognosis compared to sporadic sarcomas irrespective of histological type. Herein we report a case of a 65-year old man who underwent surgery and radiation therapy for a T4 spinal cord low-grade ...
Fisher J O - - 2013
OBJECTIVE:Large portions promote intake among children, but little is known about the external influences of the eating environment on children's self-selected portion sizes. This research experimentally tested effects of the amount of entree available and serving spoon size on children's self-served entree portions and intakes at dinner meals. A secondary ...
Yan Yu-Jun - - 2013
To analyze the treatment outcomes in pediatric cochlear implant patients with mutations in GJB2 or SLC26A4 and to determine these mutations' impact on rehabilitative outcomes. The study included 41 children who received unilateral cochlear implantations. Fifteen of these children had GJB2-related deafness, 10 had SLC26A4-related deafness, and 16 had deafness ...
Bridle Byram W BW McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, - - 2013
Histone deacetylase inhibitors (HDACi) can modulate innate antiviral responses and render tumors more susceptible to oncolytic viruses (OVs); however, their effects on adaptive immunity in this context are largely unknown. Our present study reveals an unexpected property of the HDACi MS-275 that enhances viral vector-induced lymphopenia leading to selective depletion ...
Xiao Qian - - 2013
In the visual system of invertebrates and vertebrates there are specialised groups of motion-sensitive neurons, with large receptive fields, which are optimally tuned to respond to optic flow produced by the animals' movement through the 3-D world. From their response characteristics, shared frame of reference with the vestibular or inertial ...
Hübner Patrick P PP Balance and Vision Laboratory, Neuroscience Research Australia, Cnr Barker Street & Easy Street, Randwick, - - 2013
Inhibition is critical in the pathways controlling the vestibulo-ocular reflex (VOR) and plays a central role in the precision, accuracy and speed of this important vestibular-mediated compensatory eye movement. While γ-aminobutyric acid is the common fast inhibitory neurotransmitter in most of the VOR microcircuits, glycine is also found in key ...
Alai Milind - - 2013
The objective of this study was to formulate and evaluate the lansoprazole (LPZ)-loaded microparticles to prevent nocturnal acid breakthrough in the case of gastro-esophageal reflux disease (GERD). The microparticulate delivery system was prepared by solvent evaporation method using Eudragit RS100 as a matrix polymer followed by enteric coated with Eudragit ...
Figueira Joelise Alencar - - 2013
β-Glucosidases represent an important group of enzymes due to their pivotal role in various biotechnological processes. One of the most prominent is biomass degradation for the production of fuel ethanol from cellulosic agricultural residues and wastes, where the use of immobilized biocatalysts may prove advantageous. Within such scope, the present ...
Matsushita Kohei - - 2013
PURPOSE: N-myc downstream regulated gene 1 (NDRG1) markedly reduces metastasis of numerous tumors. However, NDRG1's function in malignant tumors has not been fully determined. Therefore, we investigated the association of NDRG1 expression with clinical outcomes in neuroblastoma (NB) patients. METHODS: We obtained total RNA from residual cancer cells using microdissection ...
Rodríguez-Romero Beatriz - - 2013
Functional disability due to lumbar pain should be considered from the biopsychosocial model. There is inconclusive evidence as to whether the key determining factors in this form of disability are psychosocial or physical. Our aim is to identify variables that cause functional disability due to lumbar pain amongst shellfish gatherers ...
Dias Fernando Luiz - - 2013
Accurate early diagnosis and staging is an essential step in the management of recurrent head and neck cancer. Nevertheless, the diagnosis and staging of recurrent head and neck cancer previously treated by radiation therapy often combined with chemotherapy, remains a challenge. The differentiation between radiation induced reaction and recurrent cancer ...
Rachev Alexander - - 2013
Arteries manifest a remodeling response to long-term alterations in arterial pressure and blood flow by changing geometry, structure, and composition through processes driven by perturbations of the local stresses in the vascular wall from their baseline values. The objective of this study is twofold-to develop a general method for calculating ...
Jerez Ma José - - 2013
In this study we propose a virtual screening strategy based on the generation of a pharmacophore hypothesis, followed by an in silico evaluation of some ADME-TOX properties with the aim to apply it to the hit finding process and, specifically, to characterize new chemical entities with potential to control inflammatory ...
Avci Pinar P Harvard Medical School, Massachusetts General Hospital, Wellman Center for Photomedicine, Department of Dermatology, Boston MA, - - 2013
Discovery of novel drugs, treatments, and testing of consumer products in the field of dermatology is a multi-billion dollar business. Due to the distressing nature of many dermatological diseases, and the enormous consumer demand for products to reverse the effects of skin photodamage, aging, and hair loss, this is a ...
Lobodin Vladislav V - - 2013
We report the first charge reversal experiments performed by tandem-in-time rather than tandem-in-space MS/MS. Precursor odd-electron anions from fullerene C(60), and even-electron ions from 2,7-di-tert-butylfluorene-9-carboxylic acid and 3,3'-bicarbazole were converted into positive product ions ((-)CR(+)) inside the magnet of a Fourier transform ion cyclotron resonance mass spectrometer. Charge reversal was ...
Benkhelifa-Ziyyat Sofia S UM76 UPMC-AIM UMR S974, INSERM U 974, CNRS UMR 7215, Institut de Myologie, Université Pierre et Marie Curie, Paris, - - 2013
We have recently demonstrated the remarkable efficiency of self-complementary (sc) AAV9 vectors for central nervous system (CNS) gene transfer following intravenous delivery in mice and larger animals. Here, we investigated whether gene delivery to motor neurons (MNs) could also be achieved via intramuscular (i.m.) scAAV9 injection and subsequent retrograde transport ...
Wen Guoyuan - - 2013
A thermostable avirulent Newcastle disease virus (NDV) strain TS09-C was developed by serial passage of V4 strain in BHK-21 cells. The complete genome sequence of strain TS09-C was determined and compared with the sequences of other NDV isolates representing different thermostable phenotypes. The TS09-C genome was 15,186 nucleotides long and ...
Chandramouli Kondethimmanahalli H - - 2013
Larval growth of the polychaete worm Pseudopolydora vexillosa involves the formation of segment-specific structures. When larvae attain competency to settle, they discard swimming chaetae and secrete mucus. The larvae build tubes around themselves and metamorphose into benthic juveniles. Understanding the molecular processes, which regulate this complex and unique transition, remains ...
Abhishekh Hulegar A - - 2013
Heart rate variability (HRV) is a non-invasive method to measure cardiac autonomic function. Impairments in HRV have been proposed as independent risk factor for increased cardiac mortality and morbidity. Cardio protective phenomenon in females has been hypothesized to be due to differential autonomic tone. Age related loss of vagal control ...
Gillam David G - - 2013
OBJECTIVES: The aim of this overview is to consider the problems that may be associated with making a diagnosis of dentin hypersensitivity (DHS) and to provide a basis for clinicians to effectively diagnose and manage this troublesome clinical condition. MATERIALS AND METHODS: A PUBMED literature research was conducted by the ...
Kim Namho - - 2013
The abnormal proliferation and migration of vascular smooth muscle cell (VSMC) contributes importantly to the pathogenesis of atherosclerosis and restenosis. Here, we investigated the effects of eupatolide (EuTL), a sesquiterpene lactone isolated from the medicinal plant Inula britannica, on platelet-derived growth factor (PDGF)-induced proliferation and migration of primary rat aortic ...
Kinoshita Hidefumi - - 2013
OBJECTIVES: Salvage radiotherapy is the only curative treatment for patients with prostate cancer showing biochemical progression after radical prostatectomy. In this study, we evaluated the clinicopathological parameters that influence the outcome of salvage radiotherapy. METHODS: Medical records of 49 patients who underwent salvage radiotherapy after radical prostatectomy from 1997 to ...
Avizcuri-Inac Jose Miguel - - 2013
The overall objective of this study was to investigate the effect of manual cluster thinning (CT) and the application of the growth regulator Prohexadione Calcium (ProCa) on the phenolic composition and the sensory profile of Tempranillo and Grenache wines produced from treated vines in La Rioja (Spain). ProCa was applied ...
Senohradski K - - 2013
Hip fracture incidence in the capital city of Serbia was assessed over a period of 10 years (2000-2009). Crude annual incidence rates increased significantly for all ages and both sexes (p = 0.002). Age-adjusted rates also showed a steady increase. The mean rate of annual change for age-adjusted rates was 8.6 % (95 %CI 7.5-9.7) ...
Fernandez Rafael - - 2013
PURPOSE: Although low doses of oxygen (FiO(2) <0.50) are considered nontoxic, recent studies have shown that even lower doses increase pulmonary inflammatory mediators. We aimed to evaluate the acute effects of reducing FiO(2) on pulmonary inflammation in mechanically ventilated patients without respiratory failure. METHODS: This study was a prospective, single-center ...
Ricome Sylvie - - 2013
PURPOSE: External cooling is largely employed to induce hypothermia in comatose survivors of cardiac arrest (CA), but can fail to reach the target temperature in a reasonable time. We aimed to assess the rate of failure of external cooling after CA and to determine failure predictors. METHODS: The study was ...
Lanevskij Kiril - - 2013
Ability to cross the blood-brain barrier is one of the key ADME characteristics of all drug candidates regardless of their target location in the body. While good brain penetration is essential for CNS drugs, it may lead to serious side effects in case of peripherally-targeted molecules. Despite a high demand ...
Ai Hiroyuki - - 2013
The waggle dancers of honeybees encode roughly the distance and direction to the food source as the duration of the waggle phase and the body angle during the waggle phase. It is believed that hive-mates detect airborne vibrations produced during the waggle phase to acquire distance information, and simultaneously detect ...
Ceccaldi Alexandre - - 2013
In order to discover new inhibitors of the DNA methyltransferase 3A/3L complex, we used a medium-throughput non-radioactive screen on a random collection of 1120 small organic compounds. After a primary hit detection against DNA methylation activity of the murine Dnmt3A/3L catalytic complex, we further evaluated the EC50 of the twelve ...
Vaduganathan Muthiah - - 2013
Hospitalization for heart failure (HF) is a clinical entity associated with high postdischarge morbidity and mortality, yet few therapies are available to improve outcomes in patients with this condition. In the past decade, large phase III studies of HF treatments have failed to demonstrate drug efficacy, safety, or both, despite ...
Barabas Arpad Zsigmond - - 2013
Autoimmune diseases are initiated and maintained by complex immunopathological processes in environmental and genetic factor predisposed patients. In certain autoimmune diseases, the etiologies and pathogenesis of the conditions are quite well understood; yet in others, controversy surrounds as to why and how auto-injurious processes start. Clinical and laboratory examinations reasonably ...
Armentrout P B - - 2013
The utility of measuring the energetics of ion-molecule reactions is discussed. After distinguishing between the terms of thermodynamics (macroscopic, equilibrium quantities) and energetics (microscopic and kinetically relevant quantities), the potential energy surfaces for ion-molecule reactions are reviewed and their implications discussed. Equations describing the kinetic energy dependence of ion-molecule reactions ...
Yang Xiao X Children's Hospital of Philadelphia, Philadelphia, PA, - - 2013
We developed a strategy to treat hepatitis C virus (HCV) infection by replacing five endogenous microRNA (miRNA) sequences of a natural miRNA cluster (miR-17-92) with sequences that are complementary to the HCV genome. This miRNA cluster (HCV-miR-Cluster 5) is delivered to cells using adeno-associated virus (AAV) vectors and the miRNAs ...
Alabi Olufemi J - - 2013
The complete genome sequence of Grapevine virus E (GVE) collected from a red-berried wine grape cultivar (Cabernet Sauvignon) in Washington State was determined. The 7,568 nucleotide long genome of GVE is more similar in sequence identity with a GVE isolate from a wine grape cv. Shiraz from South Africa when ...
Raga Sonia R - - 2013
In the standard solar cell technologies such as crystalline silicon and cadmium telluride, increments of temperature in the cell produce large variations in the energy conversion efficiency, which decreases at a constant rate. In dye solar cells the efficiency remains roughly constant with a maximum at around 30-40 °C and ...
Phillip Edward E - - 2013
Sterilization conditions need to be optimized to effectively neutralize the bioburden while using short exposure times for minimizing the changes in chemical composition, material properties and device architecture. Towards this goal, effects of ethylene oxide (EtO) exposure parameters such as time, temperature, humidity, and EtO concentration on the polymer properties ...
Consedine Nathan S - - 2013
Given global demand on health workforces, understanding student enrollment motivations are critical. Prior studies have concentrated on variation in career and lifestyle values; the current work evaluated the importance of disgust sensitivity in the prediction of health career interests. We argue that emotional proclivities may be important and that disgust ...
Khan Farid - - 2013
PURPOSE: Management of hydrocephalus with insertion of ventriculoperitoneal (VP) shunt is associated with significant complications in both adult and pediatric patients. These may be more common in developing countries due to poor economic conditions and a dearth of available resources. We report a 6 years' experience with VP shunt insertion in ...
Park J-M - - 2013
BACKGROUND: Both vertebrobasilar dolichoectasia (VBD) and cerebral microbleeds (CMBs) are related with the risk of intracerebral hemorrhage. We aimed to examine the relationship between the VBD and CMB in ischaemic stroke patients. METHODS: A consecutive series of 182 patients hospitalized because of ischaemic stroke or transient ischaemic attack (TIA), and ...
Varghese George M - - 2013
The deadly combination of tuberculosis (TB) and human immunodeficiency virus (HIV) currently ravaging the world, taking a toll of about 0.35 million people every year, is one of the major public health crises of the decade. Throughout the course of HIV infection, the risk of acquisition, reactivation, and reinfection of ...
Wernick David G - - 2013
Threats to stable oil supplies and concerns over environmental emissions have pushed for renewable biofuel developments to minimize dependence on fossil resources. Recent biofuel progress has moved towards fossil resource-independent carbon cycles, but environmental issues regarding use of nitrogen fertilizers have not been addressed on a global scale. The recently ...
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