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Mendez Mario F MF Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, 300 Medical Plaza, Suite B-200, Box 956975, Los Angeles, CA 90095-6975, USA. - - 2013
The basis of hypersexual behavior among patients with dementia is not entirely clear. Hypersexual behavior may be a particular feature of behavioral variant frontotemporal dementia (bvFTD), which affects ventromedial frontal and adjacent anterior temporal regions specialized in interpersonal behavior. Recent efforts to define hypersexual disorder indicate an increasing awareness of ...
Canepa Elisa - - 2013
Besides playing a pathogenic role in Alzheimer disease, amyloid-beta peptides are normally produced in low amounts in the brain, and several lines of evidence suggest that they can modulate synaptic plasticity and memory. As cyclic adenosine monophosphate (cAMP) is known to be involved in the same processes and the blockade ...
Garimella Pranav S PS Division of Nephrology, Tufts Medical Center, Box 391, 800 Washington Street, Boston, MA 02111, - - 2013
During 2012, an observational study confirmed the high risk of cardiovascular disease ascribed to chronic kidney disease (CKD) and again raised the question of whether CKD should be considered a cardiovascular disease risk equivalent. Several other studies evaluated methods to mitigate cardiovascular risk in CKD. The results of these studies ...
Romanchuk Anna Yu - - 2013
Here we show the efficacy of graphene oxide (GO) for rapid removal of some of the most toxic and radioactive long-lived human-made radionuclides from contaminated water, even from acidic solutions (pH < 2). The interaction of GO with actinides including Am(iii), Th(iv), Pu(iv), Np(v), U(vi) and typical fission products Sr(ii), ...
Macrì Simone - - 2013
Recent data indicate that both availability and consumption of synthetic and natural psychoactive substances, marketed under the name of "legal highs", has increased. Among them, the aminoalkylindole-derivative JWH-018 is widely distributed due to its capability of binding the cannabinoid receptors CB1 and CB2 thereby mimicking the effects of classical drug ...
Minagar Alireza A Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA, - - 2013
The paired thalamic nuclei are gray matter (GM) structures on both sides of the third ventricle that play major roles in cortical activation, relaying sensory information to the higher cortical centers that influence cognition. Multiple sclerosis (MS) is an immune-mediated disease of the human CNS that affects both the white ...
Love Sharifa T - - 2013
Over 50 years ago, chromium (Cr) was proposed to be an essential trace element; however, recent studies indicate that this status should be removed as the effects of Cr supplementation appear to be pharmacological rather than nutritional. The pharmacological basis for Cr's effects can explain the inability of investigators to discover ...
Gifford Anne E - - 2013
OBJECTIVES:Mesalamine non-adherence is common among patients with ulcerative colitis (UC), and can be difficult to identify in practice. We sought to determine whether a random urine test for salicylates could be used as a marker of 5-aminosalicylic acid (5-ASA) ingestion and identify patients at risk of non-adherence. Our aim is ...
Pulicken Mathew J - - 2013
A working understanding of antiepileptic drug development, critical appraisal of drug trial design, and interpretation of study results are fundamental for the neurologist and epileptologist, to incorporate newer anticonvulsant medications into clinical practice. In this Journal Club, we evaluate a phase III study by Krauss et al.(1) that demonstrates efficacy ...
Asad Jan - - 2013
OsTZF1 is a member of the CCCH-type zinc finger gene family in rice (Oryza sativa). Expression of OsTZF1 was induced by drought, high-salt stress and H(2)O(2). OsTZF1 gene expression was also induced by abscisic acid (ABA), methyl jasmonate (MeJA) and salicylic acid (SA). Histochemical activity of β-glucuronidase (GUS), in transgenic ...
McFarland Nikolaus R - - 2013
Research in movement disorders in 2012 has improved our understanding of the pathogenic mechanisms of disease and led to development of potential novel therapeutic approaches. Key advances were linked to mechanisms underlying spread of neurodegenerative pathology, immunotherapy, stem cells, genetics and deep brain stimulation in parkinsonism and related disorders.
Luna-Palencia Gabriela R - - 2013
The alkaloids of Uncaria tomentosa micropropagated plantlets and root cultures were isolated and identified by NMR and mass spectrometry. Plantlets yielded pteropodine (1), isopteropodine (2), mitraphylline (3), isomitraphylline (4), uncarine F (5), speciophylline (6), rhynchophylline (7) and isorhynchophylline (8). In plantlets growing under continuous light, tetracyclic alkaloids 7 and 8 ...
Liu Xin - - 2013
The process of drug disposition in the lung after pulmonary delivery is complex involving absorptive and non-absorptive mechanisms. The lung has also been suggested to be a trapping and metabolizing organ, especially after intravenous administration of drug. A key challenge is to define the most suitable models for the evaluation ...
Christiansen Elisabeth - - 2013
The free fatty acid receptor 1 (FFA1, also known as GPR40) mediates enhancement of glucose-stimulated insulin secretion and is emerging as a new target for the treatment of type 2 diabetes. Several FFA1 agonists are known, but the majority of these suffer from high lipophilicity. We have previously reported the ...
Sajjad Emir Ahmed - - 2013
Initiating factors and mechanisms of tumor formation are poorly understood in nonfamilial pituitary adenomas. Alteration of intracellular pathways is an underlying event in numerous neoplasms. Among them, excessive activation of mammalian target of rapamycin (mTOR) pathway and its two main regulators, Akt and Erk, has been detected frequently in solid ...
Anhoque Carolina Fiorin - - 2013
OBJECTIVE: To evaluate the quality of life (QoL) and potential QoL determinants in patients with clinically isolated syndrome (CIS). METHODS: Eighteen CIS patients and eighteen controls were submitted to QoL evaluation with Functional Assessment of Multiple Sclerosis QoL instrument (FAMS). Cognition was evaluated with specific battery tests; Anxiety and depression ...
Pérez-Alfaro J E - - 2013
The effect of 2-chlorophenol (2-CP) on ammonium and nitrite-oxidizing processes was kinetically evaluated in batch cultures with nitrifying sludge at steady state. Assays with ammonium or nitrite as energy source and 2.5, 5.0, or 10.0 mg 2-CP-C/l were conducted. Control assays without 2-CP were also performed. Ammonium-oxidizing activity was completely inhibited ...
Yakushijin Kimikazu - - 2013
Tolvaptan is an oral vasopressin V2-receptor antagonist recognized as effective for fluid retention associated with congestive heart failure and liver cirrhosis. However, there have been no reports concerning clinical experience with tolvaptan for sinusoidal obstruction syndrome (SOS). A 42-year-old male with primarily refractory T-lymphoblastic lymphoma underwent allogeneic peripheral blood stem ...
Boucault Roberta - - 2013
Implications for Rehabilitation Six-minute walking test. The six-minute walking test is safe and widely performed in the world because of its easy implementation and low cost. Many countries have established normal values to the six-minute walking test in healthy children. However, the applicability of this test also gains popularity among ...
Al-Thihli Khalid - - 2013
BACKGROUND: Plasma/serum and dried blood spot (DBS) acylcarnitine profiles (ACPs) are key to the diagnosis of mitochondrial fatty acid β-oxidation disorders (FAODs). Despite their significant clinical applications, limited published data exists to compare their sensitivities and specificities. We retrospectively evaluated these two methods in adult patients with a history of ...
Shin Sang Hee - - 2013
OBJECTIVE: Previous reports have suggested that the incidence of spina bifida occulta in patients with nocturnal enuresis is higher than in the general population. However, the effect of spina bifida occulta on the response to nocturnal enuresis treatment is controversial. The purpose of this study was to investigate the relationship ...
Kadrmas Dan J - - 2013
Rapid multi-tracer PET aims to image two or more tracers in a single scan, simultaneously characterizing multiple aspects of physiology and function without the need for repeat imaging visits. Using dynamic imaging with staggered injections, constraints on the kinetic behavior of each tracer are applied to recover individual-tracer measures from ...
Bambace Clara - - 2013
In recent years, evidence has emerged indicating that insulin resistance and diabetes mellitus type 2 are associated with inflammation of adipose tissue (AT). Interest has been focused on epicardial AT (EAT) because of its possible involvement with atherosclerosis and cardiovascular diseases. The aim of this study was to characterize adipocyte ...
Xiao Sheng-Jun - - 2013
BACKGROUND INFORMATION: S1-1, also called RBM10, is an RNA-binding protein of 852 residues. An alteration of its activity causes TARP syndrome, a severe X-linked disorder with pre- or post-natal lethality in affected males. Its molecular function, although still largely unknown, has been suggested to be transcription and alternative splicing. In ...
Kijowski Richard - - 2013
Purpose:To determine whether the addition of a T2 mapping sequence to a routine magnetic resonance (MR) imaging protocol could improve diagnostic performance in the detection of surgically confirmed cartilage lesions within the knee joint at 3.0 T.Materials and Methods:This prospective study was approved by the institutional review board, and the ...
Bisicchia Elisa - - 2013
Endocannabinoids (eCBs) and glucocorticoids (GCs) are two distinct classes of signaling lipids that exert both neuroprotective and immunosuppressive effects; however, the possibility of an actual interaction of their receptors [i.e., type-2 cannabinoid (CB(2)) and glucocorticoid receptor α (GRα), respectively] remains unexplored. Here, we demonstrate that the concomitant activation of CB(2) ...
Bonner Laura M - - 2013
Little is known about the prevalence or predictors of seeking help for depression and PTSD from spiritual counselors and clergy. We describe openness to and actual help-seeking from spiritual counselors among primary care patients with depression. We screened consecutive VA primary care patients for depression; 761 Veterans with probable major ...
Balog A - - 2013
We conducted field surveys and experiments to evaluate the hypothesis that predation is an important driving factor determining the degree of coexistence between red and green morphs of the pea aphid Acyrthosiphon pisum. Theory suggests that the different colour morphs are differentially susceptible to natural enemies and selection by predation ...
Roksnoer Lodi C W - - 2013
Recent interest focuses on urinary renin and angiotensinogen as markers of renal renin-angiotensin system activity. Before concluding that these components are independent markers, we need to exclude that their presence in urine, like that of albumin (a protein of comparable size), is due to (disturbed) glomerular filtration. This review critically ...
Eaktasang Numfon - - 2013
In this study, a microbial fuel cell (MFC) was used to control malodorous hydrogen sulfide compounds generated from domestic wastewaters. The electricity production demonstrated a distinct pattern of a two-step increase during 170 h of system run: the first maximum current density was 118.6 ± 7.2 mA m(-2) followed by a rebound of current density ...
Dubovsky Steven L - - 2013
A proprietary combination of the atypical antipsychotic drug olanzapine and the serotonin reuptake inhibitor fluoxetine (OFC, Symbyax) was approved for the treatment of bipolar depression based on a double-blind, placebo-controlled comparison of olanzapine, OFC, and placebo. This review considers published controlled and uncontrolled studies of the efficacy, pharmacodynamics, pharmacokinetics, interactions, ...
Burgos Paci Maximiliano A - - 2013
Collisional quenching of NO A (2)Σ(+) (v = 0) by N(2)O and CO(2) has been studied through measurements of vibrationally excited products by time resolved Fourier transform infrared emission. In both cases vibrationally excited NO X (2)Π (v) is seen and quantified in levels v ≥ 2 with distributions which ...
Yuan Xing-Zhong - - 2013
For flood control purpose, the water level of the Three Gorges Reservoir (TGR) varies significantly. The annual reservoir surface elevation amplitude is about 30 m behind the dam. Filling of the reservoir has created about 349 km(2) of newly flooded riparian zone. The average flooding period lasts for more than 6 months, from ...
Tanida Takashi - - 2013
Fetal exposure to dioxins and related compounds is known to disrupt normal development of the midbrain dopaminergic system, which regulates behavior, cognition and emotion. The toxicity of these chemicals is mediated mainly by aryl hydrocarbon receptor (AhR) signaling. Previously, we identified a novel binding motif of AhR, the AhR-responsive element ...
Li Siwei - - 2013
The comparative analysis of ribonucleic acid digests (CARD) approach for sequencing of transfer ribonucleic acids (tRNAs) is described. This method is enabled by the differential labeling of two tRNA populations. A set of reference tRNAs, whose complete sequences including modifications are known, are labeled with (16)O during enzymatic digestion. The ...
Wortmann Saskia B - - 2013
Increased urinary 3-methylglutaconic acid excretion is a relatively common finding in metabolic disorders, especially in mitochondrial disorders. In most cases 3-methylglutaconic acid is only slightly elevated and accompanied by other (disease specific) metabolites. There is, however, a group of disorders with significantly and consistently increased 3-methylglutaconic acid excretion, where the ...
Chen Xiao-Yan - - 2013
The carboxyl-functionalized phosphonium ionic liquid (IL), [HCTMP][Tf(2)N], enabled the directed nucleation of monomeric or dimeric uranyl(vi) compounds. This new IL is the first carboxyl-functionalized IL which is liquid at room temperature and exhibits a wider electrochemical window and lower melting point than its ammonium analogue.
Scarpa Marco - - 2013
BACKGROUND: The main outcome parameters in oesophageal surgery have traditionally been morbidity and mortality, but quality of life (QL) has become an important consideration in view of the severity and persistence of postoperative symptoms. The aim of this study was to analyse QL before and after oesophagectomy for oesophageal cancer ...
Dunn Mary - - 2013
The following paper makes use of Kohutian self-psychology as a hermeneutic for interpreting Marie de l'Incarnation and her perplexing decision to abandon her young son Claude in favor of religious life. The author argues that filtered through the lens of Kohutian self-psychology, Marie de l'Incarnation emerges as a pathological narcissist ...
Wu Jie - - 2013
We studied the electronic structures of a series of fluorene derivatives (p/mPODPFs and p/mPOAPFs) using density functional theory calculations and investigated their performances as host materials in organic light-emitting diodes from three aspects, i.e. triplet energy, ability of charge injection from neighboring organic layer or electrode, and match of the ...
Alhalaweh Amjad A Pharmaceutical Materials Research Group, Department of Health Science, Luleå University of Technology, Luleå, 971 87, - - 2013
The purpose of this work was to characterize theophylline (THF) cocrystals prepared by spray drying in terms of the physicochemical properties and inhalation performance when aerosolized from a dry powder inhaler. Cocrystals of theophylline with urea (THF-URE), saccharin (THF-SAC) and nicotinamide (THF-NIC) were prepared by spray drying. Milled THF and ...
Maya Leticia - - 2013
Canine parvovirus (CPV) comprises three antigenic variants (2a, 2b, and 2c) with different frequencies and genetic variability among countries. Current CPV populations are considered to be spatially structured with relatively little movement of viruses between geographical areas. Here we describe the evolution and population dynamics of CPV in Uruguay from ...
Cunningham L - - 2013
BACKGROUND: Tourniquet use in orthopaedic surgery is common practice. However, the technique varies among Irish orthopaedic surgeons and there are no standard guidelines. AIM: To analyse trends in tourniquet use among Irish orthopaedic surgeons. METHODS: Ninety-two Irish orthopaedic consultants were sent a 15-survey question about tourniquet use by post. RESULTS: ...
Gevers Tom J G - - 2013
Polycystic liver disease (PLD) is arbitrarily defined as a liver that contains >20 cysts. The condition is associated with two genetically distinct diseases: as a primary phenotype in isolated polycystic liver disease (PCLD) and as an extrarenal manifestation in autosomal dominant polycystic kidney disease (ADPKD). Processes involved in hepatic cystogenesis ...
Negri F V - - 2013
Antibody-dependent cellular cytotoxicity (ADCC), which is activated by effector cells via immunoglobulin G (IgG) fragment C receptors (FcRs), was proposed as a mechanism of cetuximab efficacy. Peripheral blood mononuclear cells (PBMCs) from 23 healthy donors and 13 patients with metastatic colorectal cancer (mCRC) treated with cetuximab were tested for FcγR ...
Yomo Shoji - - 2013
Advances in chemotherapy for breast cancer (BC) have prolonged overall survival, especially for patients with human epidermal growth factor receptor-2 (HER2) positive cancer. We evaluated the effectiveness and limitations of stereotactic radiosurgery (SRS) for brain metastases (BM) from BC in conjunction with molecular targeting chemotherapy. Outcomes were retrospectively reviewed in 80 ...
Hu Ye - - 2013
Activity cliffs are formed by pairs or groups of structurally similar compounds with significant differences in potency. They represent a prominent feature of activity landscapes of compound data sets and a primary source of structure-activity relationship (SAR) information. Thus far, activity cliffs have only been considered for active compounds, consistent ...
Hao Yuanfeng - - 2013
The discovery of several new loci for resistance to Hessian fly was reported here. QHf.uga-6AL, the late HR61 was recognized from wheat cultivar 26R61 on the distal end of 6AL with resistance to both biotypes E and vH13. It is the first gene or QTL found on this particular chromosome. ...
Pagnotti Vincent S - - 2013
Solvent Assisted Ionization Inlet (SAII) produces ions in a heated inlet to a mass spectrometer from aqueous and aqueous/organic solutions with high sensitivity. However, the use of acid modifiers, which typically aids electrospray ionization, generally results in ion suppression in SAII. Here we demonstrate that the use of carbonation and ...
Steel Jason C JC Metabolism Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, - - 2013
Recombinant adeno-associated viruses (AAV) have been used for therapeutic gene transfer. These vectors offer a number of advantages including resistance to the effects of pH, a broad cellular tropism, efficient gene transfer, persistence of gene expression, and little toxicity. AAV vectors; however, at high doses can induce humoral and cellular ...
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