Search Results
Results 101 - 150 of 2982
1 2 3 4 5 6 7 8 9 10 >
Jaffe Eileen K EK Developmental Therapeutics, Institute for Cancer Research, Fox Chase Cancer Center, Temple Health, 333 Cottman Ave., Philadelphia, PA 19111, USA. - - 2013
The structural basis for allosteric regulation of phenylalanine hydroxylase (PAH), whose dysfunction causes phenylketonuria (PKU), is poorly understood. A new morpheein model for PAH allostery is proposed to consist of a dissociative equilibrium between two architecturally different tetramers whose interconversion requires a ∼90° rotation between the PAH catalytic and regulatory ...
Oliva Isabel B - - 2013
Mesenteric ischemia is a rare disease associated with high morbidity and mortality. Acute mesenteric ischemia is most commonly secondary to embolism followed by arterial thrombosis, nonocclusive ischemia, and less commonly venous thrombosis. Chronic mesenteric ischemia is almost always caused by atherosclerotic disease, with rare causes including fibromuscular dysplasia and vasculitis. ...
Stein R - - 2013
The never ending discussion about the diagnostics and treatment of vesicoureteral reflux (VUR) now includes arguments for diagnostic nihilism as well as invasive diagnostics and therapy, which is reminiscent of the debate on prostate cancer in adulthood. The common goal of all currently competing diagnostic strategies and approaches is the ...
Kanmani Paulraj - - 2013
The synthesis and functional characterization of an antibiofilm exopolysaccharide (EPS) from a probiotic Enterococcus faecium MC13 were investigated. The temperature of 35 °C, pH of 6.5, and salinity of 1-2 % were found to be optimum for EPS production. The sucrose (30 g l(-1)) and yeast extract (20 g l(-1)) acted as suitable carbon and nitrogen ...
Wen Dacheng - - 2013
MicroRNAs (miRNAs) are a class of small noncoding RNAs that negatively regulate protein expression by binding protein-coding mRNAs and repressing translation. Accumulating evidence suggests that miRNAs are involved in cancer development and progression, acting as either tumor suppressors or oncogenes. Intriguingly, it has been shown that miR-133b was significantly downregulated ...
Chen Chen - - 2013
The NIDD gene, neuronal NOS (nNOS)-interacting DHHC domain-containing protein with dendritic mRNA, codes a protein that upregulates nNOS enzyme activity by the interaction with the postsynaptic density protein 95/discsslarge/zon occlusens-1 (PDZ) domain of nNOS. Glial cell activation, especially Müller cells, may be an important factor contributing to retinal ganglion cell ...
Keenan Karen Forrest - - 2013
Whilst a growing body of work has explored family communication about Huntington's disease and how at-risk individuals learn about their risk, the experience of telling a partner and partners' experiences of finding out about this potentially devastating hereditary illness have received little attention. This study describes the experiences of partners ...
Gupta Sudhir - - 2013
The immune system has evolved to respond to pathogens (nonself) and unresponsive to self-antigens (tolerance). During the development of T and B cells in the thymus and bone marrow, respectively, self-reactive T and B cells are deleted by a process of apoptosis (both T and B cells) and become unresponsive ...
Katthagen J C - - 2013
BACKGROUND: Subscapularis (SSC) tendon tears seem to regularly occur combined with lesions of the supraspinatus (SSP) and long biceps (LBS) tendons. The aim of this study was to evaluate the rupture configurations and results after arthroscopic treatment of anterosuperior rotator cuff tears. PATIENTS AND METHODS: A total of 65 consecutively ...
Liang Xinrui - - 2013
This study was undertaken to determine the differences in the clinicopathology and survival between synchronous bilateral breast cancer (sBBC) and metachronous bilateral breast cancer (mBBC). Additionally, we analyzed the risk factors for single tumors to develop as sBBC or mBBC. Of the 190 bilateral breast cancer (BBC) cases, 84 cases ...
Gibbert J - - 2013
Due to demographic changes in the German population a significant rise in incident cases of age-related macular degeneration (AMD) is to be expected in the coming years. Also the corresponding increase in costs of the illness requires appropriate survey instruments to allow accurate estimations of costs. The cost diary for ...
Azeem Muhammad - - 2013
The pine weevil Hylobius abietis (L.) is a severe pest of conifer seedlings in reforested areas of Europe and Asia. To identify minimally toxic and ecologically sustainable compounds for protecting newly planted seedlings, we evaluated the volatile metabolites produced by microbes isolated from H. abietis feces and frass. Female weevils ...
Xu Yue - - 2013
Transcription initiation factor IIB (TFIIB) is an ideal factor to localize core promoters and plays a central role in the assembly of the pre-initiation complex. Previous studies showed that the assembly of TFIIB played an important role in rat ischemic brain injury. To elucidate the expression and possible functions of ...
Lindner Uwe - - 2013
Hydrophilic interaction chromatography (HILIC) coupled with inductively coupled plasma mass spectrometry (ICP-MS) was optimized for speciation analysis of gadolinium-based contrast agents in environmental samples, in particular surface river waters and plants. Surface water samples from the Teltow channel, near Berlin, were investigated over a distance of 5 km downstream from the ...
Krasnec Michelle O - - 2013
The cuticular hydrocarbons of the ant Formica argentea were identified by gas chromatography/mass spectrometry. Behavioral bioassays tested the role of each class of cuticular hydrocarbon in nestmate recognition, and statistical analyses looked for potential colony-specific signatures. The cuticular hydrocarbons of F. argentea consist of n-alkanes, alkenes, and methyl-branched alkanes. Behavioral ...
Placke J - - 2013
An unusual transmural tumor-like myxoid lesion was found in the cervix of the hysterectomy specimen of a 43-year-old woman. Histochemically the lesion was positive for alcian blue but negative for periodic acid Schiff (PAS) staining. The immunohistochemical staining showed positive reactions for CD10 and CD34 but negative reactions for actin. ...
Wang Jinjing - - 2013
Higher acetaldehyde concentration in beer is one of the main concerns of current beer industry in China. Acetaldehyde is always synthesized during beer brewing by the metabolism of yeast. Here, using ethanol as the sole carbon source and 4-methylpyrazole as the selection marker, we constructed a new mutant strain with ...
Adikane H V - - 2013
The chemical modification of developed ethyl cellulose-based membrane was carried out to make it suitable for bioseparation. The different reagents were used for the modification of membrane to couple protein A (PA) to study the purification of immunoglobulin G (IgG) from blood. The chemical modification was carried out using relatively ...
Norman Sonya B - - 2013
Many women have unidentified anxiety or trauma histories that can impact their health and medical treatment-seeking behavior. This study examined the sensitivity, specificity, efficiency, and sensitivity to change of the Overall Anxiety Severity and Impairment Scale (OASIS) for identifying an anxiety disorder in a female sample with and without trauma ...
Cabanis Maurice - - 2013
Attributions are constantly assigned in everyday life. A well-known phenomenon is the self-serving bias: that is, people's tendency to attribute positive events to internal causes (themselves) and negative events to external causes (other persons/circumstances). Here, we investigated the neural correlates of the cognitive processes implicated in self-serving attributions using social ...
Bilardi Jade E - - 2013
Thirty-one gay and bisexual men were interviewed on the acceptability, potential use, benefits and limitations of rapid self-testing for HIV in Australia. The majority of men supported the introduction of rapid self-testing, and would be likely to, or would use the tests for home use. However, most reported they would ...
Guida Alessandro - - 2013
In this study, a personalization method (Guida, Tardieu, & Nicolas, European Journal of Cognitive Psychology, 21: 862-896 2009) was applied to a free-recall task. Fifteen pairs of words, composed of an object and a location, were presented to 93 participants, who had to mentally associate each pair and subsequently recall ...
Ramesh Jayapal - - 2013
INTRODUCTION: While laparoscopy-assisted endoscopic retrograde cholangiopancreatography can be performed for the diagnosis and management of pancreaticobiliary diseases in patients with Roux-en-Y (RY) anatomy; the technical feasibility of performing laparoscopy-assisted endoscopic ultrasound (EUS) is unknown. METHODS: In this report, we describe the technique for performing laparoscopy-assisted EUS in two patients with ...
Wang Y - - 2013
Broadband antireflection of silicon has been realized by combining black silicon, surface passivation and surface plasmons. Black silicon, fabricated by Ag assisted chemical etching, was employed here to reduce the reflection of incident light with wavelengths below 1100 nm. Due to the increased bandgap caused by the quantum confinement effect ...
Tanimoto Ryuta - - 2013
OBJECTIVES: To describe the frequency of and to determine predictive factors associated with Radiation Therapy Oncology Group urinary toxicity in prostate brachytherapy patients. METHODS: From January 2004 to April 2011, 466 consecutive Japanese patients underwent permanent iodine-125-seed brachytherapy (median follow up 48 months). International Prostate Symptom Score and Radiation Therapy ...
Shin Yoo Seob - - 2013
Cisplatin [cis-diammine-dichloroplatinum (II)] is a widely used chemotherapeutic agent, and one of its most severe side effects is ototoxicity. In the course of developing a new protective agent against cisplatin-induced ototoxicity, we have been interested in a novel synthetic compound, 3-Amino-3-(4-fluoro-phenyl)-1H-quinoline-2,4-dione (KR-22335). We evaluated the effectiveness of KR-22335 as an ...
Ahern Todd H - - 2013
Naturally-occurring cell death is essential to the development of the mammalian nervous system. Although the importance of developmental cell death has been appreciated for decades, there is no comprehensive account of cell death across brain areas in the mouse. Moreover, several regional sex differences in cell death have been described ...
Ghosh Surajit - - 2013
Microtubule organisation in living cells is determined by spatial control of microtubule nucleation, their dynamic properties and transport by molecular motors. Here, we establish a new micro-pattern-guided method for controlling local microtubule nucleation by spatially confined immobilisation of a microtubule polymerase and show that these nucleated microtubules can be transported ...
Welch K D - - 2013
The adverse physiological effects of methyllycaconitine (MLA) have been attributed to its competitive antagonism of nicotinic acetylcholine receptors (nAChRs). Recent research suggested a correlation between the lethal dose (LD(50) ) of MLA and the amount of α(7) nAChR in various mouse strains, suggesting that mice with more α(7) nAChR require ...
Negri Armando Luis - - 2013
Fibroblast growth factor-23 (FGF-23) has emerged as an important hormone involved in phosphorus and vitamin D homeostasis. Chronic kidney disease (CKD) is the most common clinical condition in which FGF-23 levels are persistently and markedly elevated. Abnormal phosphate homeostasis and high circulating levels of FGF-23 are early complications of CKD. ...
Conrad Timothy L - - 2013
Porous and bioactive polyetheretherketone (PEEK) scaffolds have potential to replace metallic scaffolds for biologic fixation of permanent implants adjacent to trabecular bone, such as interbody spinal fusion devices. The objective of this study was to investigate the effects of the mold temperature and PEEK powder on the mechanical properties and ...
Germack David S - - 2013
Surface energy has been demonstrated as a means to direct interfacial-layer composition in polymer:fullerene blends utilized as active layers in organic photovoltaic (OPV) devices. Combined with recent materials advances in the preparation of nanoscale chemical patterns, surface energy directed control of nanophase separation presents an opportunity to employ patterned surface ...
Watson Charles C - - 2013
In PET/MR systems having the PET component within the uniform magnetic field interior to the MR, positron beams can be injected into the PET field of view (FOV) from unshielded emission sources external to it, as a consequence of the action of the Lorentz force on the transverse components of ...
Goubert C - - 2013
Parasitoids of phytophagous insects face a detectability-reliability dilemma when foraging for hosts. Plant-related cues are easily detectable, but do not guarantee the presence of the host. Host-related cues are very reliable, but much harder to detect from a distance. Little is known in particular about the way coleopteran parasitoid females ...
Barbehenn Raymond V - - 2013
The nutritional value of alternative host plants for leaf-feeding insects such as caterpillars is commonly measured in terms of protein quantity. However, nutritional value might also depend on the quality of the foliar protein [i.e., the composition of essential amino acids (EAAs)]. A lack of comparative work on the EAA ...
Chen Hong - - 2013
We report the biomimetic synthesis of polyethylene glycol (PEG) grafted silica nanoplates templated by double hydrophilic PEG-b-poly-l-lysine diblock copolymers. The silica nanoplates can be re-dispersed in PEG selective solvents. The sizes of silica nanoplates can be tuned from a few hundred nanometers to tens of micrometers.
Dasary Samuel S R - - 2013
Iodine is a biophilic and essential trace element for all life and especially for vertebrates, which require it to produce indispensable thyroid hormones in their thyroid glands. As a result, the adequate measurement of iodine in water and food samples is crucial to lead a healthy life. Motivated by its ...
Oruç Ayla Sargın - - 2013
PURPOSE: Ghrelin, an endogenous ligand for the growth hormone secratogogue receptor, and its receptors are found in the reproductive organs and placenta. Motilin is produced from the endocrine cells of the duodeno jejunal mucosa and considered to be a regulator of interdigestive migrating contractions. Aim of this study is to ...
Chandra Pranjal - - 2013
Simple and general cancer cell detection methods are required in point-of-care diagnostics. Herein, the interaction between an anticancer drug, daunomycin, and cancer cell membrane components has been studied using an aptamer probe immobilized on a conducting polymer-gold nanoparticle composite film through electrochemical and fluorescence methods and applied to the quantitative ...
Rabiei Faradonbeh Moosa - - 2013
Disposing solid residue with high liquid content into the environment may impact the immediate ecosystem and its surroundings. In bitumen recovery process from oil sands, it is environmentally and economically desirable to effectively recover as much of the liquid trapped in the spent solids as possible, prior to releasing it ...
Chen Lei - - 2013
In order to screen dioxin pollution in sediment of Three Gorges Dam (TGD) area, three sediment cores were obtained from two sites in 2010~2011; each core was divided into different samples with every 10 cm depth. Sediment dating determined by radiometry ((137)Cs, (210)Pb) and concentrations of dioxins were analyzed by high-resolution ...
Cury Valéria C R - - 2013
Functional mobility of children with cerebral palsy (CP) is influenced by personal and environmental factors, serving as barriers and/or facilitators and impacting on children's strategies and functional outcome. OBJECTIVES: To describe typical mobility methods used by children with CP at home, school and community and to compare them across family's ...
Machova Polakova Katerina - - 2013
The efficacy of therapeutic modalities in chronic myeloid leukemia (CML) depends on both genetic and epigenetic mechanisms. This review focuses on epigenetic mechanisms involved in the pathogenesis of CML and in resistance of tumor cells to tyrosine kinase inhibitors leading to the leukemic clone escape and propagation. Regulatory events at ...
Wang Shao-Juan - - 2013
Five novel perhydrobenzannulated 5,5-spiroketal sesquiterpenes, namely, pleurospiroketals A-E (1-5), were isolated from the culture of the edible mushroom Pleurotus cornucopiae. Pleurospiroketals D (4) and E (5) were obtained as an isomeric mixture with a ratio of 5:4. Their structures were established by NMR, X-ray single-crystal diffraction, and CD data analysis. ...
Lima José M M - - 2013
Nitric oxide (NO) is an important chemical compound involved in many physiological and pathological processes in living organisms. However, nitric oxide is a very reactive radical that needs to be carried through organisms to reach the desired biological target. With the aim of developing new compounds that can be used ...
Shie Dung-Yun - - 2013
Abstract Conclusion: Our findings suggest that, in Asian patients with severe obstructive sleep apnea (OSA), obesity is a better predictor of uvulopalatopharyngoplasty (UPPP) failure than Friedman stage III. Objectives: This study evaluated UPPP success rates in obese and non-obese Asian patients treated for severe OSA. Methods: Records of patients who ...
Halawi Ali - - 2013
In light of the increasing prevalence of obesity worldwide, the popularity of bariatric surgery is on the rise. As with any other invasive procedure, these surgeries, especially with the obesity risk factor, carry the risk of direct cutaneous complications following the penetration and manipulation of tissues. In addition, bariatric surgery ...
Laubert Tilman - - 2013
PURPOSE: Presently, no markers exist to predict metachronous metastasis at the time a primary colorectal cancer is diagnosed. While aneuploidy indicates poor survival prognosis and elevated carcinoembryonic antigen (CEA) levels the presence of recurrent disease, the predictive value of both markers regarding imminent metachronous metastases is unclear. METHODS: Sixty patients ...
Hinduja Sameer - - 2013
Cyberbullying is a problem affecting a meaningful proportion of youth as they embrace online communication and interaction. Research has identified a number of real-world negative ramifications for both the targets and those who bully. During adolescence, many behavioral choices are influenced and conditioned by the role of major socializing agents, ...
Succi Isabella B - - 2013
Onychomycosis constitutes up to 50% of all nail disorders. Toenails are generally affected, mostly due to dermatophytes. Terbinafine is the most potent antifungal agent in vitro against dermatophytes. There are few randomised controlled trials using a non-continuous dose of terbinafine. The aim of this open-label pilot study was to reduce ...
1 2 3 4 5 6 7 8 9 10 >