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Novetsky Akiva P AP Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO 63110, USA. - - 2013
Lithium chloride (LiCl) has been shown to demonstrate anticancer properties at supratherapeutic doses. This study was designed to determine whether LiCl, as a single agent or in combination with cytotoxic agents, reduces ovarian cancer cell growth and metabolic activity at clinically achievable levels. We studied the effects of LiCl on ...
Setacci C - - 2013
Execution of carotid artery stenting (CAS) requires not only excellent manual dexterity, and a high level of competence, but also in-depth knowledge of the carotid pathology, of the materials available on the market and of the different techniques to apply in given situations. Actually each individual moment of the procedure ...
Chavarria Laia - - 2013
Acute-on-chronic liver failure is the term that refers to sustained liver injury with acute decompensation, usually induced by a precipitating factor. A common link between ensuing failures of various organs is impairment of the vascular supply, which may also induce vasogenic oedema in the brain. The aim of this study ...
Asarbakhsh Mariam - - 2013
Background:  Usability is the ease with which something can be used, but this essential concept appears to be rarely considered when using technology for teaching and learning in medical education. Context:  There is an increasing use of technology in an attempt to enhance teaching and learning in medical education, from ...
Armenian Saro H SH Department of Population Sciences, City of Hope National Medical Center, Duarte, California 91010-3000, USA. - - 2013
Five-year survival for many childhood cancers approaches 80%, and there is a growing number of long-term survivors in the United States. These survivors are at risk for developing adverse health-related complications. We highlight recently published studies that provide new insight into the association between specific therapeutic exposures and late-occurring complications ...
Goehring Jenny L JL Boys Town National Research Hospital, 425 North 30th Street, Omaha, NE 68131, - - 2013
Objectives were as follows: 1) to evaluate the incidence of abnormal cochlear implant electrode impedance intraoperatively and at the initial activation, 2) to identify the percentage of abnormalities that resolve by the initial activation, and 3) to determine the incidence of normal intraoperative impedances that present as abnormal at the ...
Snydman Laura - - 2013
Background:  Resident doctors (residents) play a significant role in the education of medical students. Morning work rounds provide an optimal venue to assess resident teaching. The purpose of this study was to assess the feasibility of peer observation of resident work rounds, to evaluate resident perceptions of peer observation and ...
Vance Gillian - - 2013
Background:  The trainee-held learning portfolio is integral to the foundation programme in the UK. In the Northern Deanery, portfolio assessment is standardised through the Annual Review of Competence Progression (ARCP) process. In this study we aimed to establish how current trainees evaluate portfolio-based learning and ARCP, and how these attitudes ...
Mathias K - - 2013
Filters are a valuable aid for safe carotid artery stenting, but require good knowledge of their function, and their shortcomings. Filters capture visible particles in 5-20% and microscopically in about 70% of the cases. Transcranial Doppler ultrasound and diffusion weighted MRI investigations have shown that particles are released during filter ...
Quatrano Nicola A - - 2013
Physicians need to be prepared to counsel patients on why and how to protect themselves from damaging ultraviolet (UV) radiation, including the proper use of sunscreens. In this article, we review the interplay between UV radiation, sunscreens and the skin, highlighting current controversies and recommendations surrounding sunscreen use. An important ...
Brändström Helge - - 2013
The objectives were to first determine incidence and contributing factors to cold-related injuries in Northern Sweden, both of those that led to hospitalisation and those that led to fatality. A further aim was to assess post-cooling hand-rewarming responses and the effects of training in a cold environment, both on fingertip ...
Bertog S C - - 2013
Carotid stenting has become a commonly used procedure for the treatment of carotid artery stenosis. Though equipment and techniques have improved tremendously over the recent 3 decades, complications do occur. It is important for carotid operators to be familiar with potential complications and adverse events. In this article complications and ...
Min Yang Won - - 2013
Acute hepatic failure (AHF) is one of the most serious complications of transcatheter arterial chemoembolization (TACE). The aims of this study were to investigate risk factors of AHF after TACE and to establish a predictive model for AHF. In the evaluation set, a total of 820 patients who underwent TACE ...
Roffi M - - 2013
The history of carotid artery stenting (CAS) was made by brave men and women who believed in a less invasive treatment modality than carotid endarterectomy (CEA) to treat carotid stenosis despite the risk - which was obviously present also with surgery - to cause a stroke, the very event that ...
Anderson Kirstie K Newcastle Hospitals NHS Foundation Trust, Newcastle University, Newcastle, - - 2013
Primary biliary cirrhosis (PBC) patients frequently describe sleep problems. The cause remains unclear and treatment is challenging. Restless leg syndrome (RLS) is a common sleep disorder. In this study, we systematically screened PBC patients for the presence of RLS. Participants were recruited from our specialist PBC clinical service. Subjects completed ...
Brousil James - - 2013
Femoral fractures in children are the commonest children's fracture requiring hospitalization. They consume disproportionate amounts of healthcare resource. Advances in operative management have resulted in improved clinical and health economic outcomes. This article describes 21st-century management of femoral fractures concentrating on recent advances. There is a clear trend to increased ...
Komeili Mariam - - 2013
Bilingual children are frequently misdiagnosed as having Specific Language Impairment (SLI). Misdiagnosis may be minimized by tests with high degrees of sensitivity and specificity. The current study used a new test, the School-Age Sentence Imitation Test-English 32 (SASIT-E32), to investigate sentence repetition in monolingual and bilingual children, and specifically to ...
Simonetti G - - 2013
Ischemic stroke is the third leading cause of death and most common cause of permanent disability in industrialized nations. Eighty-five percent of strokes are ischemic in nature, with an associated mortality between 53% and 92%. The focus of treatment for acute stroke starts with prompt and accurate diagnosis of ischemic ...
Shah Anand - - 2013
Background:  Critical incident analysis reveals that poor performance in 'human-factor' or non-technical skills, such as decision making, leadership, teamwork and situational awareness, are frequently identified as key underlying features leading to adverse events. Simulation technology is a rapidly emerging modality used to develop technical and non-technical skills within specialist training ...
Bartman Ilona - - 2013
Background:  Performance assessments rely on human judgment, and are vulnerable to rater effects (e.g. leniency or harshness). Making valid inferences from performance ratings for high-stakes decisions requires the management of rater effects. A simple method for detecting extreme raters that does not require sophisticated statistical knowledge or software has been ...
Novogrodsky Rama - - 2013
In the current study, storytelling and story retelling by children with autism spectrum disorder (ASD) were analyzed to explore ambiguous third-person pronoun use in narratives. Twenty-three children diagnosed with ASD aged 6;1 to 14;3 and 17 typically-developing (TD) children aged 5;11 to 14;4 participated in the study. In the retelling ...
Roffi M - - 2013
In the absence of randomized data, the optimal management of patients with severe carotid and coronary artery disease (CAD), especially those undergoing coronary bypass grafting (CABG), remains unsettled. As a general rule, in patients with multilevel atherosclerotic disease the symptomatic vascular discrict should be treated first. The entirely surgical approach ...
Garzón Luz N - - 2013
ABSTRACT Common bean production is constrained by many fungal, viral, and bacterial pathogens. Thus, the identification of resistance (R) genes is an important focal point of common bean research. The main goal of our study was to identify resistance gene homologues (RGH) in the crop, using degenerate primers designed from ...
Sakuma Shun - - 2013
Barley (Hordeum vulgare) spikes are developmentally switched from two-rowed to six-rowed by a single recessive gene, six-rowed spike 1 (vrs1), which encodes a homeodomain-leucine zipper I class transcription factor. Vrs1 is a paralog of HvHox2 and both were generated by duplication of an ancestral gene. HvHox2 is conserved among cereals, ...
Reuken Philipp A - - 2013
Bacterial infections increase mortality four-fold in patients with decompensated cirrhosis. However, specific mortality associated with urinary tract infections (UTI) in cirrhosis is not known. Retrospective single-centre analysis of all hospitalized patients with cirrhosis and ascites who underwent first paracentesis between 2006 and 2011 to determine 90-day mortality associated with UTI ...
Stabile E - - 2013
Carotid artery stenting (CAS) is considered to be an acceptable alternative to carotid endarterectomy (CEA), particularly in patients at increased risk for CEA. The safety of CAS has improved significantly over the past decade. Adjunctive use of embolic protection devices (EPDs), is thought to be partially responsible for the improved ...
Palma Bernardo B - - 2013
Interindividual variability in cytochrome P450 (CYP)-mediated xenobiotic metabolism is extensive. CYP metabolism requires two electrons, which can be donated by NADPH cytochrome P450 oxidoreductase (CYPOR) and/or cytochrome b5 (b5). Although substantial number of studies have reported on the function and effect of b5 in CYP-mediated catalysis, its mode of action ...
Setacci C - - 2013
Treatment of acute stroke is time-dependent, with the best outcomes resulting from the earliest interventions. However, for patients with acute ischemic stroke due to a high-grade stenosis of the internal carotid artery, despite maximal medical treatment, an effective intervention to improve their neurologic symptoms and clinical outcome has not yet ...
Albustanji Yusuf M - - 2013
The studies of agrammatism show that not all morpho-syntactic elements are impaired to the same degree and that some of this variation may be due to language-specific differences. This study investigated the production of morpho-syntactic elements in 15 Jordanian-Arabic (JA) speaking individuals with agrammatism and 15 age-matched neurologically healthy individuals. ...
Yamada R - - 2013
During the last 20 years, asymptomatic patients with high-grade carotid stenosis have been treated with carotid endarterectomy and more recently with carotid artery stenting in order to prevent stroke. New, best medical treatment including statins, beta-blockers, antiplatelet therapies, and better diabetes and blood pressure control might reduce the incidence of ...
Xue Bingye - - 2013
ABSTRACT Parasitism genes encode effector proteins that are secreted through the stylet of root-knot nematodes to dramatically modify selected plant cells into giant-cells for feeding. The Mi8D05 parasitism gene previously identified was confirmed to encode a novel protein of 382 amino acids that had only one database homolog identified on ...
Darbyshire Daniel - - 2013
Background:  Handover is a key activity in acute health care, with patient safety implications if it is not performed well. This is becoming more important with shorter working hours and therefore a greater number of handovers. Despite this there is a paucity of evidence to guide education to enhance practice. ...
Moratto R - - 2013
Carotid artery stenting (CAS) represents a valid alternative to carotid endarterectomy (CEA). Possible embolization during the approach and the cannulation of the supra-aortic arterial trunks remains an important obstacle to CAS. This risk is increased in elderly patients and complex anatomies. In order to achieve satisfactory technical and clinical outcomes, ...
Robbins Matthew S - - 2013
Although the comorbidity of migraine has been extensively studied, the relationships between cluster headache and psychiatric disease have not been well-addressed. In this review the available literature concerning cluster headache and depression, anxiety, bipolar disorder, aggression, suicide, and their implications are discussed. Potential mechanisms, confounding variables, and unanswered questions are ...
Baylis Tammy - - 2013
Leaves depend on highly developed venation systems to collect fixed carbon for transport and to distribute water. We hypothesized that local regulation of auxin biosynthesis plays a role in vein development. To this effect, we assessed the role of the SHORT INTERNODES/STYLISH (SHI/STY) gene family, zinc-finger transcription factors linked to ...
Efe Cumali - - 2013
Antibodies to soluble liver antigen (anti-SLA) are specific serological markers of autoimmune hepatitis (AIH). The clinical significance and frequency of anti-SLA have never been reported among AIH patients from Italy and Turkey. To retrospectively assess the estimated prevalence, sensitivity, specificity and clinical significance of anti-SLA in AIH and various liver ...
Marone E M - - 2013
Endovascular repair of the thoracic aorta (TEVAR) has been recently considered an appealing alternative to open treatment of traumatic aortic injuries. However, the use of this technique in emergency is often limited by hemodynamic instability, severe associated lesions and unavailability of adequate materials. Dedicated stent-grafts are not currently available. We ...
Andreu Llorenç L Cognitive Neuroscience and Information Technologies Research Program, IN3, Universitat Oberta de Catalunya, Barcelona, - - 2013
This study investigated the formulation of verb argument structure in Catalan- and Spanish-speaking children with specific language impairment (SLI) and typically developing age-matched controls. We compared how language production can be guided by conceptual factors, such as the organization of the entities participating in an event and knowledge regarding argument ...
Rampersad Sephra N - - 2013
ABSTRACT Colletotrichum gloeosporioides sensu lato is widely distributed throughout temperate and tropical regions and causes anthracnose disease in numerous plant species. Development of effective disease management strategies is dependent on, among other factors, an understanding of pathogen genetic diversity and population stratification at the intraspecific level. For 132 isolates of ...
Okada Yoshihisa - - 2013
Statins, which are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase and inhibit endogenous cholesterol synthesis, possess pleiotropic activities, such as anti-inflammatory, anti-oxidative and antifibrotic effects. Here, we investigated whether statins ameliorate steatohepatitis using a high-fat and high-cholesterol (HFHC) diet-induced rat model. Eight-week-old male Sprague-Dawley rats were fed control chow or HFHC ...
Graceffa Philip P Boston Biomedical Research Institute, Watertown, MA 02472, USA. - - 2013
Oxidation of actin monomer (G-actin) with copper o-phenanthroline resulted in a rapid, high yield of disulfide cross-linked dimer. The cross-link is due to an intermolecular disulfide bond between actin Cys374 of each molecule, resulting in a tail-to-tail, i.e., antiparallel, actin dimer. Analytical ultracentrifugation profiles of G-actin can be ascribed to ...
Cremin Ide - - 2013
: Antiretroviral drugs can reduce HIV acquisition among uninfected individuals (as pre-exposure prophylaxis: PrEP) and reduce onward transmission among infected individuals (as antiretroviral treatment: ART). We estimate the potential impact and cost-effectiveness of antiretroviral-based HIV prevention strategies. : We developed and analysed a mathematical model of a hyperendemic setting with ...
Nakamura Kyle J KJ Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, CA, - - 2013
A vaccine capable of providing cross-clade, sterilizing protection has been the holy grail of HIV-1 prevention and control since the beginning of the pandemic. A major component of this effort has been the identification and characterization of broadly neutralizing antibodies (bNAbs). Recent advances in bNAb isolation, structure-based engineering, and vector-mediated ...
Das Payel P Computational Biology Center, IBM Thomas J. Watson Research Center, Yorktown Heights, New York 10598, United - - 2013
Recent molecular dynamics simulations have suggested important roles for nanoscale dewetting in the stability, function, and folding dynamics of proteins. Using a synergistic simulation-experimental approach on the αTS TIM barrel protein, we validated this hypothesis by revealing the occurrence of drying inside hydrophobic amino acid clusters and its manifestation in ...
Hagn Franz F Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, United - - 2013
Structural studies of membrane proteins are still hampered by difficulties of finding appropriate membrane-mimicking media that maintain protein structure and function. Phospholipid nanodiscs seem promising to overcome the intrinsic problems of detergent-containing environments. While nanodiscs can offer a near-native environment, the large particle size complicates their routine use in the ...
Lo Su-Tang ST Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, - - 2013
Dendrimers are a class of structurally defined macromolecules featured with a central core, a low-density interior formed by repetitive branching units, and a high-density exterior terminated with surface functional groups. In contrast to their polymeric counterparts, dendrimers are nanosized and symmetrically shaped, which can be reproducibly synthesized on a large ...
Selvaraj Stalin - - 2013
The present study investigates dose-dependent effects of trans-resveratrol on the membrane fluidity using planar lipid bilayer and liposome models. The complex admittance plots obtained for the lipid bilayer show that resveratrol below 60 μM preferentially interacts with the polar headgroups at the membrane-electrolyte interface, leading to enhanced membrane admittance and ...
Murphy Taylor A TA Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, Tennessee 37235, - - 2013
Accurate quantification of cell specific rates and their uncertainties is of critical importance for assessing metabolic phenotypes of cultured cells. We applied two different methods of regression and error analysis to estimate specific metabolic rates from time-course measurements obtained in exponentially growing cell cultures. Using simulated data sets to compute ...
Morrison Peter W J PW School of Pharmacy, University of Reading , Whiteknights, P.O. Box 224, Reading, RG6 6AD, United - - 2013
Cyclodextrins are water-soluble cyclic oligosaccharides consisting of six, seven, and eight α-(1,4)-linked glucopyranose subunits. This study reports the use of different cyclodextrins in eye drop formulations to improve the aqueous solubility and corneal permeability of riboflavin. Riboflavin is a poorly soluble drug with a solubility up to 0.08 mg mL(-1) ...
Yates John R JR 3rd Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines, SR11, LaJolla, California 92037, United - - 2013
Mass spectrometry has evolved at an exponential rate over the last 100 years. Innovations in the development of mass spectrometers have created powerful instruments capable of analyzing a wide range of targets, from rare atoms and molecules to very large molecules, such as a proteins, protein complexes, and DNA. These ...
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