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Nickerson Kevin M KM Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06510, - - 2013
Nucleic acid-reactive B cells frequently arise in the bone marrow but are tolerized by mechanisms including receptor editing, functional anergy, and/or deletion. TLR9, a sensor of endosomal dsDNA, both promotes and regulates systemic autoimmunity in vivo, but the precise nature of its apparently contradictory roles in autoimmunity remained unclear. In ...
Shafiei Fereshteh - - 2013
Abstract Objective. This in vitro study evaluated the effect of soft-start curing mode by LED unit on the marginal microleakage of silorane composite restoration. Materials and methods. Class V cavities were prepared on the buccal surfaces of 80 extracted molars at the cementoenamel junction and randomly divided into eight groups. ...
Ng Aubree A AA The Jungers Center for Neurosciences Research, Department of Neurology, Oregon Health & Science University, Portland, OR 97239, - - 2013
The demyelinating peripheral neuropathy Charcot-Marie-Tooth type 4B (CMT4B) is characterized by axonal degeneration and myelin outfoldings. CMT4B results from mutations in either myotubularin-related protein 2 (MTMR2; CMT4B1) or MTMR13 (CMT4B2), phosphoinositide (PI) 3-phosphatases that dephosphorylate phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2, lipids which regulate endo-lysosomal membrane traffic. The catalytically active MTMR2 ...
Cranford Steven W - - 2013
The past fifty years have seen a surge in the use of materials for clinical application, but in order to understand and exploit their full potential, the scientific complexity at both sides of the interface-the material on the one hand and the living organism on the other hand-needs to be ...
Anagnostis Panagiotis - - 2013
Background:  Special attention has been given to the effect of vitamin D supplementation on fertility outcomes in both sexes. Aims:  The purpose of this narrative review was to elucidate the role of vitamin D in male and female reproduction, providing current evidence from both animal and human studies. Materials and ...
Carney Patricia A PA Departments of Family Medicine and Public Health and Preventive Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239-3098, USA. - - 2013
To develop criteria to identify thresholds for the minimally acceptable performance of physicians interpreting diagnostic mammography studies. In an institutional review board-approved HIPAA-compliant study, an Angoff approach was used to set criteria for identifying minimally acceptable interpretive performance for both workup after abnormal screening examinations and workup of a breast ...
Shahbazi M A MA Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, - - 2013
  Long-acting intramuscular penicillin G injection is an important product for the management of some severe infections. However, testing the bioequivalence of such long-acting formulations is difficult. Our aim was to undertake such a test using a generic formulation containing 1 200 000 IU of benzathine penicillin G powder and an innovator's product ...
Gilbert Benjamin - - 2013
Whether introduced species invasions pose a major threat to biodiversity is hotly debated. Much of this debate is fueled by recent findings that competition from introduced organisms has driven remarkably few plant species to extinction. Instead, native plant species in invaded ecosystems are often found in refugia: patchy, marginal habitats ...
Lanni Thomas - - 2013
The aim of this study is to perform a cost analysis to compare adjuvant radiation therapy schedules following breast conserving surgery. Treatment planning and delivery utilization data were modeled for a series of 10 different breast RT techniques. The whole breast (WB) regimens consisted of: (1) Wedge based WB (25 ...
Darricarrère Nicole - - 2013
The Piwi protein subfamily is essential for Piwi-interacting RNA (piRNA) biogenesis, transposon silencing, and germ-line development, all of which have been proposed to require Piwi endonuclease activity, as validated for two cytoplasmic Piwi proteins in mice. However, recent evidence has led to questioning of the generality of this mechanism for ...
Salas Valentina - - 2013
We have evaluated the in vitro activity of voriconazole against 61 strains of Aspergillus fumigatus by using broth microdilution, disk diffusion, and minimal fungicidal concentration procedures. We observed an excellent correlation between the results obtained with the three methods. Five percent of the strains showed MICs greater than or equal ...
Li J - - 2013
Satellite cells are the resident stem cell population of adult skeletal muscle tissue that is responsible for growth and regeneration. The cells typically congregate near the tips of the muscle fibers and in close proximity to the neural muscular junction (NMJ). Ephrin-A5 is a chemotactic molecule that participates in the ...
Hallström Hadar - - 2013
Abstract Aim. Probiotic bacteria have been introduced for prevention and treatment of periodontal diseases. The aim was to assess if daily oral administration of probiotic bacteria could influence the inflammatory response and the composition of supragingival plaque in an experimental gingivitis model. Materials and methods. Eighteen healthy female adults volunteered ...
Broux Thibault - - 2013
This experiment emphasizes the first example of two-phase sequential Rietveld refinements throughout a solid/gas chemical reaction monitored by Neutron Powder Diffraction (NPD) at high temperature. The reduction of the n = 1 Ruddlesden-Popper (RP) oxide Sr(2)MnO(4) heated under a flow of 5% H(2)-He has been investigated throughout two heating/cooling cycles ...
Blackwood Bronagh B Queen's University Belfast, Centre for Infection & Immunity, School of Medicine, Dentistry & Biomedical Sciences, Belfast, Northern Ireland. - - 2013
To determine whether the daily use of 5% tea tree oil (TTO) body wash (Novabac 5% Skin Wash) compared with standard care [Johnson's Baby Softwash (JBS)] had a lower incidence of methicillin-resistant Staphylococcus aureus (MRSA) colonization. The study setting was two intensive care units (ICUs; mixed medical, surgical and trauma) ...
Fiorentino Maria M University of Maryland, Mucosal Biology Research Center, Baltimore, Maryland, - - 2013
Helicobacter pylori infection of the stomach is related to the development of diverse gastric pathologies. The ability of H. pylori to compromise epithelial junctional complexes and to induce proinflammatory cytokines is believed to contribute to pathogenesis. The purpose of this study was to use an in vitro human gastric epithelial ...
Brilene Tatjana - - 2013
Coagulase-negative staphylococci (CoNS) are the leading cause of late-onset sepsis (LOS) in neonates. Increasing resistance of CoNS to beta-lactams and aminoglycosides has led to widespread use of vancomycin, which in turn may lead to resistance to vancomycin. Thus, combination therapy of LOS has been advocated. We aimed to determine the ...
Volz Shelley - - 2013
BACKGROUND: Our breast cancer clinic promotes patient use of decision and communication aids (DAs/CAs) through two mechanisms: coaching and prompting. From January through September 2010, we provided services to 462 of 1106 new visitors (42%). Of those 462 visitors, 267 (58%) received coaching. For the remainder (195 or 42%), the ...
Viner Maya - - 2013
Purpose:To evaluate how interreader agreement and the site of the volume of interest (VOI) affect the agreement and variability of liver mean standardized uptake value normalized to lean body mass (SUL(mean)) at fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT).Materials and Methods:Institutional review board approval was obtained for ...
Benso Andrea - - 2013
OBJECTIVE: Growth hormone (GH) secretion is regulated by an interplay between GH-releasing hormone (GHRH), somatostatin (SST) and other central and peripheral signals. Acylated ghrelin (AG) amplifies GH pulsatility acting, at least partially, independently from GHRH and SST. The GH response to GHRH is inhibited by recombinant human GH (rhGH), likely ...
Tsuji Hideo - - 2013
Changes in the thymic microenvironment lead to radiation-induced thymic lymphomagenesis, but the phenomena are not fully understood. Here we show that radiation-induced chromosomal instability and bystander effects occur in thymocytes and are involved in lymphomagenesis in C57BL/6 mice that have been irradiated four times with 1.8-Gy γ-rays. Reactive oxygen species ...
Steinmetz Sonja - - 2013
PURPOSE: In humans, traumatic brain injury (TBI) is one of the most common causes of acquired (symptomatic) epilepsy, but as yet there is no treatment to prevent the development of epilepsy after TBI. Animal models of posttraumatic epilepsy (PTE) are important to characterize epileptogenic mechanisms of TBI and to identify ...
Nowicka Anna M - - 2013
Binding of mitoxantrone (MXT) to double stranded DNA has been investigated as a model drug-DNA binding system to evaluate the effects of various forms of chromium on the binding properties. We have found that Cr(III), which binds strongly to DNA, does not affect the MXT affinity to DNA. In contrast, ...
Krsek Pavel - - 2013
PURPOSE: To assess the predictive value of ictal single-photon emission computed tomography (SPECT) for outcome after excisional epilepsy surgery in a large population of children with focal cortical dysplasia (FCD). METHODS: One hundred seventy-three ictal SPECT studies in 106 children with histologically proven FCD were retrospectively analyzed. The extent and ...
Kohmura Yukiko Kobayashi - - 2013
Rapid growth in infancy considerably increases the risk of obesity and metabolic disorders in adulthood especially among neonates born small. To investigate the mechanism involved, we developed an animal model of undernourishment in utero by maternal caloric restriction, in which the Z scores of body weight at weaning (19.5 days) ...
Ciruela Pilar - - 2013
The aim of this study was to investigate risk factors for the most common serotypes of invasive pneumococcal disease (IPD). A total of 293 IPD cases were analyzed in children aged 3-59 mo in a community with intermediate vaccination coverage with the 7-valent pneumococcal vaccine (PCV7). IPD cases were reviewed ...
Mazzio Katherine A - - 2013
A one pot method for organic/colloidal CdSe nanoparticle hybrid material synthesis is presented. Relative to traditional ligand exchange processes, these materials require smaller amounts of the desired capping ligand, shorter syntheses and fewer processing steps, while maintaining nanoparticle morphology.
Pan Sudip - - 2013
The noble-gas-trapping ability of the star-shaped C(5) Li(7) (+) cluster and O(2) Li(5) (+) super-alkali cluster is studied by using ab initio and density functional theory (DFT) at the MP2 and M05-2X levels with 6-311+G(d,p) and 6-311+G(d) basis sets. These clusters are shown to be effective noble-gas-trapping agents. The stability ...
Martin C - - 2013
The aim of this work was to compare the joint kinetics and stroke production efficiency for the shoulder, elbow, and wrist during the serve between professionals and advanced tennis players and to discuss their potential relationship with given overuse injuries. Eleven professional and seven advanced tennis players were studied with ...
Ahmadi N - - 2013
This study investigates the occurrence and distribution pattern of infectious pancreatic necrosis virus (IPNV) within the pancreas, liver, kidney and spleen of naturally infected cultured rainbow trout, Oncorhynchus mykiss (Walbaum), using immunohistochemistry (IHC). A nested PCR was also employed to confirm the presence of the virus in the pooled tissues ...
Evans Angela D - - 2013
Lying is a pervasive human behavior. Evidence to date suggests that from the age of 42 months onward, children become increasingly capable of telling lies in various social situations. However, there is limited experimental evidence regarding whether very young children will tell lies spontaneously. The present study investigated the emergence ...
Chapman Robert - - 2013
Water-soluble organic nanotubes were prepared by convergently conjugating polymers of hydroxyethyl acrylate (HEA) and acrylic acid (AA) to self-assembling cyclic octapeptides of alternating D and L chirality. The structure of the self-assembled tubes was characterised in a number of polar solvents, and notably water, by using light scattering, TEM and small ...
Gruber V - - 2013
As part of its projected European Atlas of Natural Radiation (EANR), the Joint Research Centre (JRC) of the European Commission, in cooperation with research institutions and radioprotection authorities all over Europe, is currently developing a map of the geogenic radon potential. In an accompanying report the state of knowledge, mapping ...
Kobayashi Nobuaki N Cancer and Inflammation Program, National Cancer Institute, Frederick, MD 21702, - - 2013
The primary goal of cancer immunotherapy is to elicit an immune response capable of eliminating the tumor. One approach toward accomplishing that goal uses general (rather than tumor-specific) immunomodulatory agents to boost the number and activity of pre-existing CTLs. We find that the intratumoral injection of polyguanosine (poly-G) oligonucleotides (ODN) ...
Wu Zhanhong - - 2013
Because islet transplantation has become a promising treatment option for patients with type 1 diabetes, a noninvasive imaging method is greatly needed to monitor these islets over time. Here, we developed an (18)F-labeled exendin-4 in high specific activity for islet imaging by targeting the glucagonlike peptide-1 receptor (GLP-1R). METHODS: Tetrazine ...
Yang Robert T RT Department of Cariology, Restorative Sciences and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109, - - 2013
Normal dentin mineralization requires two highly acidic proteins, dentin sialoprotein (DSP) and phosphophoryn (PP). DSP and PP are synthesized as part of a single secreted precursor, DSP-PP, which is conserved in marsupial and placental mammals. Using a baculovirus expression system, we previously found that DSP-PP is accurately cleaved into DSP ...
Boltz Marie - - 2013
AIM: To describe fear of falling in hospitalised older adults and its relationship with patient characteristics and physical function and explore patient views of associated factors. BACKGROUND: Functional decline is a common complication in hospitalised older adults, associated with low mobility and physical activity. Fear of falling may contribute to ...
Leong Be Kim - - 2013
Abstract Purpose: This study aims to describe the presence and severity of extracranial concomitant injuries in traumatic brain injury (TBI) patients and to ascertain their effect on long-term functional outcome. Method: A retrospective cohort study was performed in a single-center recruiting patients with first episode of TBI. The types and ...
Adams Anna L - - 2013
Native chemical ligation is widely used for the convergent synthesis of proteins. The peptide thioesters required for this process can be challenging to produce, particularly when using Fmoc-based solid-phase peptide synthesis. We have previously reported a route to peptide thioesters, following Fmoc solid-phase peptide synthesis, via an N→S acyl shift ...
Durà-Vilà Glòria G Department of Mental Health Sciences, University College London, UK. - - 2013
The psychological consequences of sexual abuse are generally serious and enduring, particularly when the perpetrator is known and trusted by the survivor. This paper explores the experiences of five contemplative nuns who were sexually abused by priests and the spiritual journeys that followed. In the context of an ethnographic study ...
Wakeford Richard - - 2013
Since the early years of follow-up of the Japanese atomic-bomb survivors, it has been apparent that childhood leukaemia has a particular sensitivity to induction by ionising radiation, the excess relative risk (ERR) being expressed as a temporal wave with time since exposure. This pattern has been generally confirmed by studies ...
Smith Katherine R KR Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne 3052, - - 2013
Kufs disease, an adult-onset neuronal ceroid lipofuscinosis, is challenging to diagnose and genetically heterogeneous. Mutations in CLN6 were recently identified in recessive Kufs disease presenting as progressive myoclonus epilepsy (Type A), whereas the molecular basis of cases presenting with dementia and motor features (Type B) is unknown. We performed genome-wide ...
Bächler Pablo - - 2013
Purpose:To validate the use of particle traces derived from four-dimensional (4D) flow magnetic resonance (MR) imaging to quantify in vivo the caval flow contribution to the pulmonary arteries (PAs) in patients who had been treated with the Fontan procedure.Materials and Methods:The institutional review boards approved this study, and informed consent ...
Hertwig Ralph - - 2013
OBJECTIVE: . To investigate diagnostic accuracy in patient histories involving nonspecific complaints and the extent to which characteristics of physicians and structural properties of patient histories are associated with accuracy. METHODS: . Six histories of patients presenting to the emergency department (ED) with nonspecific complaints were provided to 112 physicians: ...
Janik Miroslaw - - 2013
This study examined correlations between radon, thoron and thoron progeny concentrations based on surveys conducted in several different countries. For this purpose, passive detectors developed or modified by the National Institute of Radiological Sciences (NIRS) were used. Radon and thoron concentrations were measured using passive discriminative radon-thoron detectors. Thoron progeny ...
Delvendahl Igor I Carl-Ludwig Institute for Physiology, University of Leipzig, 04103 Leipzig, - - 2013
Over a century ago, the Spanish anatomist Ramón y Cajal described 'mossy fibres' in the hippocampus and the cerebellum, which contain several presynaptic boutons. Technical improvements in recent decades have allowed direct patch-clamp recordings from both hippocampal and cerebellar mossy fibre boutons (hMFBs and cMFBs, respectively), making them ideal models ...
Gizzo Salvatore - - 2013
Background:Postpartum hemorrhage (PPH) is a potentially fatal complication of vaginal and cesarean deliveries. The active management of the third stage of labor provides administration of prophylactic uterotonic drugs just before or immediately after delivery, since they reduce the risk of PPH by 60%.Objective:Overview on all available uterotonics for PPH prevention ...
Petrucci Maria T - - 2013
Multiple myeloma (MM) typically follows a relapsing course with many patients requiring multiple therapies. This single-arm phase 2 study prospectively evaluated the efficacy and safety of bortezomib retreatment in MM patients who had relapsed after achieving at least a partial response (≥PR) to prior bortezomib-based therapy. Patients aged ≥18 years, with ...
Verma Ramesh R Department of Community Medicine; Pt. B.D. Sharma PGIMS; Rohtak, Haryana - - 2013
Leptospirosis is an infectious disease of worldwide distribution that is caused by pathogenic spirochete bacteria of the genus Leptospira. It is transmitted by the urine of an infected animal and contagious in a moist environment. Epidemiological studies indicate that infection is commonly associated with certain occupational workers such as farmers, ...
Pattison John E - - 2013
In this study, some characteristics of the photo-electrons produced when natural background gamma radiation interacts with micron-sized depleted uranium (DU) particles in the human body have been estimated using Monte Carlo simulations. In addition, an estimate has been made of the likelihood of radiological health effects occurring due to such ...
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