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Cooke Georga Pe - - 2013
ABSTRACT: BACKGROUND: Burnout and intolerance of uncertainty have been linked to low job satisfaction and lower quality patient care. While resilience is related to these concepts, no study has examined these three concepts in a cohort of doctors. The objective of this study was to measure resilience, burnout, compassion satisfaction, ...
Wang Zhen Z Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, - - 2013
Chloroplast membrane lipid synthesis relies on the import of glycerolipids from the ER. The TGD (TriGalactosylDiacylglycerol) proteins are required for this lipid transfer process. The TGD1, -2, and -3 proteins form a putative ABC (ATP-binding cassette) transporter transporting ER-derived lipids through the inner envelope membrane of the chloroplast, while TGD4 ...
Heyman Gail D - - 2013
The ability of 3- and 4-year-old children to disregard advice from an overtly misleading informant was investigated across five studies (total n = 212). Previous studies have documented limitations in young children's ability to reject misleading advice. This study was designed to test the hypothesis that these limitations are primarily due to ...
Pepe Margaret Sullivan MS Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. - - 2013
Authors have proposed new methodology in recent years for evaluating the improvement in prediction performance gained by adding a new predictor, Y, to a risk model containing a set of baseline predictors, X, for a binary outcome D. We prove theoretically that null hypotheses concerning no improvement in performance are ...
Gaspar Emanuelle B - - 2013
Colonization of the nasopharynx by non-pathogenic Neisseria species, including N. lactamica, has been suggested to lead to the acquisition of natural immunity against Neisseria meningitidis in young children. The aim of this study was to identify a model complex of antigens and adjuvant for immunological preparation against N. meningitidis B, ...
Choi V W Y - - 2013
An adaptive response is a biological response where the exposure of cells or animals to a low priming exposure induces mechanisms that protect the cells or animals against the detrimental effects of a subsequent larger challenging exposure. In realistic environmental situations, living organisms can be exposed to a mixture of ...
Kim Sung Tae ST Department of Chemistry, University of Massachusetts-Amherst, 710 North Pleasant St., Amherst, MA 01003, - - 2013
Surface properties dictate the behavior of nanomaterials in vitro, in vivo, and in the environment. Such properties include surface charge and hydrophobicity. Also key are more complex supramolecular interactions such as aromatic stacking and hydrogen bonding, and even surface topology from the structural to the atomic level. Surface functionalization of ...
King Brian A - - 2013
INTRODUCTION: An increasing number of U.S. states and communities have implemented smoke-free policies prohibiting smoking in all indoor workplaces and public areas. Public attitudes toward smoke-free environments are an evidenced-based, key indicator for the successful implementation and enforcement of smoke-free policies. METHODS: Data were obtained from the 2009-2010 National Adult ...
Brandstack Nina - - 2013
Purpose:To evaluate whether quantitative diffusion-tensor tractography can show abnormalities in long association tracts of subjects with symptoms after traumatic brain injury without any visible signs of intracranial or intraparenchymal abnormalities of obvious traumatic origin at routine magnetic resonance (MR) imaging and to determine the number and type of these abnormalities.Materials ...
Kim Jeong-Lim - - 2013
Objective. To investigate respiratory symptoms and respiratory-related absence from work among Swedish health care workers (HCW). Methods. From a postal questionnaire study among a general Swedish working population (n=12 186), we identified 2156 HCW (555 assistant nurses, 377 nurses, 109 physicians and 1115 others), including 429 with mainly cleaning tasks ...
Riccobene Todd A - - 2013
This study was conducted to determine the safety, tolerability, and pharmacokinetics of intravenous doses of ceftaroline fosamil administered in combination with the novel non-β-lactam β-lactamase inhibitor avibactam in healthy adults. In the single-dose, open-label arm, 12 subjects received single 1-h intravenous infusions of ceftaroline fosamil alone (600 mg), avibactam alone ...
Gümüş Hatice - - 2013
To determine if the specimen without calcification, as depicted on specimen radiography, made any contribution to the final histopathological diagnosis in comparison to the specimen with calcification. The records of 1312 stereotactic vacuum-assisted biopsies for breast microcalcifications between February 2000 and December 2010 were reviewed retrospectively. Following specimen x-ray the ...
Griesdale Donald Eg - - 2013
ABSTRACT: The observational literature suggests that hypernatremia is associated with worse outcomes in patients with traumatic brain injury. In a previous issue of Critical Care, Wells and colleagues add to this literature by failing to show an association between hypernatremia and reduced intracranial pressure. However, we must bear in mind ...
Chen Fang - - 2013
HER2 (ErbB2) has been reported to be overexpressed in 20-30% of breast cancer and confers poor survival because of high proliferation and metastasis rates. MicroRNAs are small noncoding RNAs that are responsible for the posttranscriptional regulation of target genes. We found miR-199b-5p inhibited HER2 expression by direct targeting its 3'-untranslated ...
Bai Jiu-Xu - - 2013
Although tamoxifen (TAM), a selective estrogen receptor modulator, has been widely used in the treatment of hormone-responsive breast cancer, its estrogen-like effect increases the risk of endometrial cancer. However, the molecular mechanisms of TAM-induced endometrial carcinoma still remain unclear. In this report, we explored the role of microRNAs (miRNAs) in ...
Propst Evan J - - 2013
A female infant with CHARGE syndrome and a long type IV cleft extending to within 5 mm of the carina underwent transcervical repair at 5 weeks of age. The trachea was transected from the cricoid cartilage and was peeled off the esophagus. The front of the esophagus and the back ...
Cassetta Michele - - 2013
PURPOSE: Recently, cone beam computed tomography (CBCT) has become widely used for oral and maxillofacial imaging. Twenty dry mandibles were CBCT and conventional multislice CT scanned to evaluate if there is a statistically significant difference between the bone density values they produce, defined as gray density values, and to determine ...
Tsao James - - 2013
ABSTRACT: INTRODUCTION: Stimulating the commitment of implanted dystrophin+ muscle derived stem cells (MDSC) into myogenic, as opposed to lipofibrogenic lineages, is a promising therapeutic strategy for Duchenne muscular dystrophy (DMD). METHODS: To examine whether counteracting myostatin, a negative regulator of muscle mass and a pro-lipofibrotic factor, would help this process, ...
Loh Choy Theng - - 2013
Pseudocontact shifts (PCS) from paramagnetic lanthanide ions present powerful long-range structural restraints for structural biology by NMR spectroscopy, but site-specific tagging of proteins with lanthanides remains a challenge, as most of the available lanthanide tags require proteins with single cysteine residues. We show that cyclen-based paramagnetic lanthanide tags can be ...
Tycko Robert R Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. - - 2013
Many peptides and proteins self-assemble into amyloid fibrils. Examples include mammalian and fungal prion proteins, polypeptides associated with human amyloid diseases, and proteins that may have biologically functional amyloid states. To understand the propensity for polypeptides to form amyloid fibrils and to facilitate rational design of amyloid inhibitors and imaging ...
Niu Teng-Fei - - 2013
A novel kind of bisfunctional nitrogen heterocycle containing both 1,2,3-triazole and isoxazole scaffolds has been prepared. The protocol utilized alkynyl substituted amines as the bifunctional linkers to combine a copper-free triazole synthesis with a hypervalent iodine-mediated isoxazole cycloaddition through a chemoselective process. This method has also been exemplified in the ...
Fruchter Oren - - 2013
BACKGROUND AND OBJECTIVE: Transbronchial lung biopsies (TBB) remain the gold standard to establish the presence of allograft rejection or infection after lung transplantation. We aimed to evaluate the efficacy and safety of cryo- transbronchial biopsies (cryo-TBB) in lung transplantation patients. METHODS: Forty lung transplantation patients (mean age 58.3 years) underwent ...
Langert Kelly A - - 2013
Recruitment and trafficking of autoreactive leukocytes across the blood-nerve barrier is an early pathological insult in Guillain-Barré syndrome (GBS), an aggressive autoimmune disorder of the PNS. Whereas the etiology and pathogenesis of GBS remain unclear, pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α), are reported to be elevated early in the ...
Dean Jason - - 2013
Chinese hamster ovary (CHO) cells are commonly used for industrial production of recombinant proteins in fed batch or alternative production systems. Cells progress through multiple metabolic stages during fed batch antibody (mAb) production, including an exponential growth phase accompanied by lactate production, a low growth or stationary phase when specific ...
Kvitting Anna S - - 2013
Objective. To validate A Quick Test of Cognitive Speed (AQT) as an instrument in diagnostic dementia evaluations against final clinical diagnosis and compare AQT with the Mini-Mental State Examination (MMSE) and Clock Drawing Test (CDT) in primary care. Design. Primary health care cohort survey. Setting. Four primary health care centres ...
Thayer Desiree A DA Department of Physiology, and Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, - - 2013
The Golgi complex is essential for many aspects of cellular function, including trafficking and sorting of membrane and secretory proteins and posttranslational modification by glycosylation. We observed reversible fragmentation of the Golgi complex in cultured hippocampal neurons cultured in hyperexcitable conditions. In addition, Golgi fragmentation was found in cultured neurons ...
Knobel S M - - 2013
Two hundred and forty heifers were fed at Oklahoma State University in Stillwater, in one of two treatment groups: a dry rolled corn (CON) diet or a diet including 30% wet distillers grain plus solubles (WDGS). Chuck rolls (n = 60) and paired strip loins (n = 75 pairs; 38 ...
Wagemans Annemieke Ma - - 2013
Background:Not much is known about the process of end-of-life decision-making for people with intellectual disabilities.Aim:To clarify the process of end-of-life decision-making for people with intellectual disabilities from the perspective of patient representatives.Design:A qualitative study based on semi-structured interviews, recorded digitally and transcribed verbatim. Data were analysed using Grounded Theory procedures.Participants:We ...
Huisman Mv - - 2013
Acute deep vein thrombosis (DVT) and pulmonary embolism (PE) represent two expressions of a similar clinical pathological process, often referred to as venous thromboembolism (VTE). It has long been recognized that, as clinical signs and symptoms of PE and DVT are not specific for the diagnosis, objective diagnosis in both ...
Albert Eva M - - 2013
Habitat transformation is one of the leading drivers of biodiversity loss. The ecological effects of this transformation have mainly been addressed at the demographic level, for example, finding extinction thresholds. However, interpopulation genetic variability and the subsequent potential for adaptation can be eroded before effects are noticed on species abundances. ...
Carmignani Amedeo - - 2013
Aortic injuries represent a rare but life-threatening complication of spinal surgery. Perforation of the aorta due to pedicle screw penetration or misplacement can lead to immediate bleeding with hemodynamic instability or to pseudoaneurysm development with delayed risk of rupture, which can occur weeks to months later. Recently, thoracic endovascular aortic ...
Wodlinger Brian - - 2013
OBJECTIVES: Pain due to peripheral neuropathy is extremely difficult to treat as drugs often become less and less effective over the course of a patient's life. In order to augment such treatments, electrical stimulation has become relatively common, in the form of transcutaneous electrical nerve stimulation, peripheral nerve stimulation, and ...
Shen M K - - 2013
This trial aimed to compare the maternal and neonatal effects of remifentanil given by patient-controlled analgesia (PCA) or continuous infusion for labour analgesia. Patient controlled analgesia was administered using increasing stepwise boluses from 0.1 to 0.4 μg.kg(-1) (0.1 μg.kg(-1) increment, 2 min lockout, n = 30). Continuous infusion used rates ...
Hennig Andreas - - 2013
The surface of poly(methyl methacrylate) particles with different amounts of a grafted layer of poly(acrylic acid) was labeled with varying degrees of an amino derivative of fluorescein isothiocyanate. The resulting fluorescent polymer particles were analyzed by absorption spectroscopy and by steady-state and time-resolved fluorescence spectroscopy including measurements of the fluorescence ...
Koll Brian S - - 2013
The incidence, severity, and associated costs of Clostridium difficile (C. difficile) infection (CDI) have dramatically increased in hospitals over the past decade, indicating an urgent need for strategies to prevent transmission of C. difficile. This article describes a multifaceted collaborative approach to reduce hospital-onset CDI rates in 35 acute care ...
Legarth Rebecca - - 2013
Background: Several studies have demonstrated an increased risk of non-AIDS cancers in HIV patients and, for some cancers, also in relatives of HIV patients. We aimed to estimate (1) the risk of anal carcinoma among HIV patients and their parents, and (2) the mortality after a diagnosis of anal carcinoma. ...
Kerwin Edward M - - 2013
Chronic obstructive pulmonary disease (COPD) is a progressive disease in which patients become increasingly disabled by their symptoms and limited in their activities. Health-related quality of life may be profoundly impaired even in the early stages of the disease. Treatment with long-acting inhaled bronchodilators can improve lung function, symptoms and ...
Yokoyama Akira - - 2013
AIMS: The life-time drinking profiles of Japanese alcoholics have shown that gastrectomy increases susceptibility to alcoholism. We investigated the trends in gastrectomy and alcohol dehydrogenase-1B (ADH1B) and aldehyde dehydrogenase-2 (ALDH2) genotypes and their interactions in alcoholics. METHODS: This survey was conducted on 4879 Japanese alcoholic men 40 years of age ...
Fulton Rachael L - - 2013
BACKGROUND AND PURPOSE: Approved use of intravenous alteplase for ischemic stroke offers net benefit. Pooled randomized controlled trial analysis suggests additional patients could benefit but others be harmed with treatment initiated beyond 4·5 h after stroke onset. We proposed prognostic scoring methods to identify a strategy for patient selection. METHODS: We ...
Varilly Patrick - - 2013
We use transition path sampling to study evaporation in the SPC/E model of liquid water. On the basis of thousands of evaporation trajectories, we characterize the members of the transition state ensemble (TSE), which exhibit a liquid-vapor interface with predominantly negative mean curvature at the site of evaporation. We also ...
Szmukler George - - 2013
Risk assessment has assumed increasing salience in mental health care in a number of countries. The frequency of serious violent incidents perpetrated by people with a mental illness is an insufficient explanation. Understandings of mental illness and of the role of those charged with their care (or control) play a ...
Lacquaniti Antonio A Department of Internal Medicine, University of Messina, Via Salita Villa Contino 30, 98100 Messina, - - 2013
To evaluate the utility of serum and urinary neutrophil gelatinase-associated lipocalin (NGAL) in depicting an event of contrast material-induced nephropathy (CIN) in patients who received iodinated contrast media, gadoterate meglumine, or radiopharmaceutical technetium-99m ((99m)Tc) and to evaluate the protective effect exerted by isotonic saline infusion, sodium bicarbonate administration, or N-acetylcysteine ...
Noei Heshmat - - 2013
Deprotonating a base: High-resolution electron energy loss spectroscopy and ultrahigh vacuum infrared spectroscopy have been used to determine that high surface coverage can induce proton transfer from adsorbed ammonia to surface oxygen atoms on both single crystals and nanoparticles of ZnO (see picture; Zn blue sticks, O red, N blue ...
Iida Tatsuo - - 2013
Abstract Conclusion: Using magnetic resonance imaging (MRI), endolymphatic hydrops could be visualized on both sides after intratympanic (IT) injection of gadolinium contrast agents (Gd) in one symptomatic ear and subsequent intravenous (IV) Gd injection. The MRI revealed a difference of intracochlear Gd distribution between the IT injection side and the ...
Gamero Amparo - - 2013
AIM: Among the most important factors influencing wine quality are yeast strains and fermentation temperature. Fermentation at low temperature is presently used in winemaking to improve both aroma formation and retention. In this study, we have analysed the oenological characteristics of Tempranillo wines produced at 12 °C and 28 °C ...
Lee Dong-Gun - - 2013
Reduced bactericidal efficacy at a high inoculum is known as the inoculum effect (IE). We used neutropenic mice to compare the IEs of ceftobiprole (CFB), daptomycin (DAP), linezolid (LZD), and vancomycin (VAN) against 6 to 9 strains of Staphylococcus aureus and 4 strains of Streptococcus pneumoniae at 2 inocula in ...
Salleras Luis - - 2013
The aim of this study was to systematically review published studies that evaluated the efficiency of inactivated influenza vaccination in preventing seasonal influenza in children. The vaccine evaluated was the influenza-inactivated vaccine in 10 studies and the virosomal inactivated vaccine in three studies. The results show that yearly vaccination of ...
Ito Ryousuke - - 2013
β-Amyrin, a natural triterpene, is widely distributed in plant kingdom and its pentacyclic skeleton is produced by oxidosqualene cyclase (OSC). OSC enzymes are classified as membrane proteins and they catalyze the polycyclization reaction of (3S)-2,3-oxidosqualene to yield nearly 150 different cyclic triterpene skeletons. To date, no report has described for ...
Menon Kavya R - - 2013
Microalgae have significant potential to be an important alternative energy source, but the challenges to the commercialization of bio-oil from microalgae need to be overcome for the potential to be realized. The application of stress can be used to improve bio-oil yields from algae. Nevertheless, the understanding of stress effects ...
Cohen Milton M Pain Medicine and Rheumatology, St Vincent's Campus, Sydney, New South - - 2013
The discovery of neuroplastic phenomena such as central sensitization of nociception has challenged pain theory to evolve, to encompass unpredictable and unlikely chronic pain states, and to cope with the emerging complexity of the brain. Recently, the proposition that chronic pain is a disease in its own right has gained ...
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