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Results 501 - 550 of 2988
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Bridle Byram W BW McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, - - 2013
Histone deacetylase inhibitors (HDACi) can modulate innate antiviral responses and render tumors more susceptible to oncolytic viruses (OVs); however, their effects on adaptive immunity in this context are largely unknown. Our present study reveals an unexpected property of the HDACi MS-275 that enhances viral vector-induced lymphopenia leading to selective depletion ...
Hübner Patrick P PP Balance and Vision Laboratory, Neuroscience Research Australia, Cnr Barker Street & Easy Street, Randwick, - - 2013
Inhibition is critical in the pathways controlling the vestibulo-ocular reflex (VOR) and plays a central role in the precision, accuracy and speed of this important vestibular-mediated compensatory eye movement. While γ-aminobutyric acid is the common fast inhibitory neurotransmitter in most of the VOR microcircuits, glycine is also found in key ...
Stoven Samantha S Mayo Clinic, Division of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, MN 55905, - - 2013
Currently, the only treatment for celiac disease is a gluten-free diet, and there is an increased desire for alternative therapies. In vitro and in vivo models of celiac disease have been generated in order to better understand the pathogenesis of celiac disease, and this review will discuss these models as ...
Mendez Mario F MF Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, 300 Medical Plaza, Suite B-200, Box 956975, Los Angeles, CA 90095-6975, USA. - - 2013
The basis of hypersexual behavior among patients with dementia is not entirely clear. Hypersexual behavior may be a particular feature of behavioral variant frontotemporal dementia (bvFTD), which affects ventromedial frontal and adjacent anterior temporal regions specialized in interpersonal behavior. Recent efforts to define hypersexual disorder indicate an increasing awareness of ...
Miao Weimin W State Key Laboratory for Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Center for Stem Cell Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, - - 2013
High levels of reactive oxygen species (ROS) can exhaust hematopoietic stem cells (HSCs). Thus, maintaining a low state of redox in HSCs by modulating ROS-detoxifying enzymes may augment the regeneration potential of HSCs. Our results show that basal expression of manganese superoxide dismutase (MnSOD) and catalase were at low levels ...
Lyons Heidi H Department of Sociology/Anthropology, Oakland University, Rochester, MI 48309, USA. - - 2013
Casual sex is often associated with the young adult stage in the life course. Most recent research on the prevalence, motives, and consequences of heterosexual casual sex has relied on samples of college students, yet students are only a small and advantaged subset of the young adult population. The current ...
Lee Min J MJ Department of Neurobiology and Anatomy, The University of Texas-Medical School at Houston, PO Box 20708, Houston, TX 77225, - - 2013
Cocaine is one of well-known drugs of abuse, and many children experience early exposure to cocaine. Because of an immature neuronal system in adolescents, they may react differently to repeated cocaine administration compared to adults. Most of the published papers report the effect of cocaine on adult male rats and ...
Garimella Pranav S PS Division of Nephrology, Tufts Medical Center, Box 391, 800 Washington Street, Boston, MA 02111, - - 2013
During 2012, an observational study confirmed the high risk of cardiovascular disease ascribed to chronic kidney disease (CKD) and again raised the question of whether CKD should be considered a cardiovascular disease risk equivalent. Several other studies evaluated methods to mitigate cardiovascular risk in CKD. The results of these studies ...
Sanchez C C Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital, Texas Children's Hospital, Houston, TX 77030, - - 2013
Prostate cancer remains a significant health problem for men in the Western world. Although treatment modalities are available, these do not confer long-term benefit and are accompanied by substantial side effects. Adoptive immunotherapy represents an attractive alternative to conventional treatments as a means to control tumor growth. To selectively target ...
Buttner Melissa M MM Department of Psychology, University of Iowa, Iowa City, IA, USA. - - 2013
Postpartum depression (PPD) is a significant public health concern with prevalence of major and minor depressions reaching 20 % in the first three postpartum months. Sociodemographic and psychopathology correlates of PPD are well established; however, information on the relationship between premenstrual disorders and the development of PPD is less well ...
Sossdorf Maik - - 2013
ABSTRACT: Analyzing medical records of 979 patients with severe sepsis or septic shock provided some evidence that the use of low-dose aspirin or non-steroidal anti-inflammatory drugs (NSAIDs) was associated with decreased hospital mortality. However, the benefit was abolished when aspirin and NSAIDs were given together.
Kolb Adam Geoffrey AG Internal Medicine Residency, Hennepin County Medical Center, Minneapolis, MN, - - 2013
Chronic eosinophilic pneumonia (CEP) is a rare interstitial lung disease characterized by subacute dyspnea, peripheral infiltrates on imaging, and pulmonary eosinophilia. We report a case of a 48-year-old man who presented to a "minute clinic" with cough and dyspnea. After improvement on a short course of steroids for a presumptive ...
Zeinali-Davarani Shahrokh S Department of Mechanical Engineering, Boston University, 110 Cummington Mall, Boston, MA 02215, - - 2013
Arteries are composed of multiple constituents that endow the wall with proper structure and function. Many vascular diseases are associated with prominent mechanical and biological alterations in the wall constituents. In this study, planar biaxial tensile test data of elastase-treated porcine aortic tissue (Chow et al. in Biomech Model Mechanobiol ...
Jamieson Nigel B NB West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Alexandra Parade, Glasgow, G31 2ER, UK. - - 2013
The poor overall survival associated with pancreatic ductal adenocarcinoma (PDAC) despite complete resection suggests that occult metastatic disease is present in most at the time of surgery. Resection margin involvement (R1) following resection is an established poor prognostic factor. However, the definition of an R1 resection varies and the impact ...
Taule T T Department of Occupational Therapy, Haukeland University Hospital, Bergen, - - 2013
Retrospective, cross-sectional design. To identify factors that predict unsatisfactory seating pressure in spinal cord-injured (SCI) individuals. Seating Clinic at the University Hospital, Norway. All wheelchair users with traumatic SCI hospitalized between 1 January 2007 and 31 December 2010 were included. Individual assessment by a team was performed. To measure seating ...
Celik E C EC Department of Physical Medicine and Rehabilitation, Istanbul Physical Medicine and Rehabilitation Training Hospital, Istanbul, Turkey. - - 2013
Prospective, randomized and controlled study. The aim of the study was to investigate the effect of low-frequency transcutaneous electrical nerve stimulation (LF-TENS) in the treatment of neuropathic pain in patients with spinal cord injury (SCI). A total of 33 SCI patients with neuropathic pain were included in the study. History, ...
Morris J J Roosevelt University, Department of Psychology, Chicago, IL 60605, USA. - - 2013
Survey. Compare views of disability in able-bodied and spinal cord-injured individuals. United States. A group of able-bodied individuals were asked to imagine that they had sustained a spinal cord injury (SCI), then complete the Appraisals of DisAbility: primary and secondary scale (ADAPSS) as if they were injured. The mean scores ...
Flores Andressa Caroline AC Laboratory of Microbial Biotechnology, Department of Biotechnology, Genetics and Cell Biology (DBC), State University of Maringá (UEM), Maringá, PR, - - 2013
The compound 3-nitropropionic acid is a potent neurotoxic agent in animals and well-known as a potent inhibitor of Mycobacterium tuberculosis. In this research, we were able to extract this compound from the endophytic fungus, Phomopsis longicolla (FJ62759), isolated from Trichilia elegans A. JUSS ssp. elegans. The aim of this study ...
McNulty James K JK Department of Psychology, Florida State University, 1107 W. Call St., Tallahassee, FL 32306-4301, USA. - - 2013
There is theoretical reason to believe narcissism is associated with a number of sexual behaviors and outcomes that affect both sexual and relationship satisfaction. Nevertheless, research on the association between personality and behavior demonstrates that personality traits, such as narcissism, only predict behavior in domains that activate the components of ...
Tanaka Akane - - 2013
Drinking water is an important nutrient for human health. The mineral ingredients included in drinking water may affect the physical condition of people. Various kinds of natural water are in circulation as bottled water in developed countries; however, its influence on clinical conditions of patients with certain diseases has not ...
Zhang Hui - - 2013
A novel star-shaped zinc porphyrin cored [5]rotaxane with four rotaxane arms was synthesized and well characterized by (1)H, (13)C NMR spectroscopy and HR-ESI mass spectrometry. The introduction of the zinc porphyrin core enabled the [5]rotaxane to have a fixed shape and symmetrical structure, and the simultaneous shuttling motion of four ...
Sticchi Laura - - 2013
HBV surface antigen (HBsAg) variants may impair diagnosis or allow the virus to escape vaccine-induced immunity and their circulation in the population can represent a Public Health threat. Their prevalence, however, is not yet completely established. Evidence indicates that amino acid substitutions within HBsAg can lead to conformational changes which ...
Frahm Grant E - - 2013
Abstract Context: At elevated temperatures, studies have shown that serum albumin undergoes irreversible changes to its secondary structure. Anionic fatty acids and/or anionic surfactants have been shown to stabilize human serum albumin (HSA) against thermal denaturation through bridging hydrophobic domains and cationic amino acids residues of the protein. Objective: As ...
Nam Julian - - 2013
BACKGROUND : Recent evidence has suggested that intra-arterial thrombolysis may provide benefit beyond intravenous thrombolysis in ischemic stroke patients. Previous meta-analyses have only compared intra-arterial thrombolysis with standard treatment without thrombolysis. The objective was to review the benefits and harms of intra-arterial thrombolysis in ischemic stroke patients. METHODS : We undertook a ...
Humphries Christopher M - - 2013
OBJECTIVES: Pectus excavatum is associated with varying degrees of exercise intolerance and symptomatology. Various forms of evaluation have been inconsistent in identifying objective data for correlation with symptoms. Cardiac magnetic resonance (CMR) imaging provides a promising method for delineating the anatomical and physiological components of pectus excavatum as well as ...
Kokita Tomoyuki - - 2013
Climate changes on various time scales often shape genetic novelty and adaptive variation in many biotas. We explored molecular signatures of directional selection in populations of the ice goby Leucopsarion petersii inhabiting a unique sea basin, the Sea of Japan, where a wide variety of environments existed in the Pleistocene ...
Gorbacheva Evgenia O - - 2013
The first formal [3 + 3]-cycloaddition of nitronates with donor-acceptor cyclopropanes is reported. The reaction is catalyzed by ytterbium trifluoromethanesulfonate and leads to hitherto unknown bicyclic nitrosoacetals, possessing two annelated six-membered rings.
Beekman Andrew Michael - - 2013
A synthetic approach accessing the pestalotiopsones, fungal chromones possessing a rare skeletal subtype, is reported for the first time. The synthesis of pestalotiopsone A () has been achieved in 7 linear steps (28%), from commercially available 3,5-dimethoxybenzoic acid and subsequently the first syntheses of pestalotiopsone B (), C () and ...
Otero S C - - 2013
OBJECTIVE: To determine differences between parents and children in ratings of child health-related quality of life (HRQL) prior to growth hormone treatment. METHOD: HRQL measures were collected from 144 children and their caregivers. Inclusion criteria were aged between 10 and 16 years, diagnosed with Turner's syndrome, acquired or idiopathic growth ...
Choi V W Y - - 2013
In this study, microbeam protons were used to provide the priming dose to induce an in vivo radioadaptive response (RAR) in the embryos of zebrafish, Danio rerio, against subsequent challenging doses provided by x-ray photons. The microbeam irradiation system (Single-Particle Irradiation System to Cell, acronym SPICE) at the National Institute ...
Travetti Olga - - 2013
Feline injection-site sarcoma (FISS) may be a consequence of subcutaneous injection. In the present study, the medical records and the computed tomography (CT) features of 22 cats with a FISS, histopathological subtype fibrosarcoma, were used. The majority of the fibrosarcomas (45%) were located in the interscapular region. All fibrosarcomas, except ...
Tomlinson Alan - - 2013
Abstract Purpose: Dry eye is often characterized by increased tear evaporation due to poor tear film quality, especially of the lipid component of the tear film. Using an environmental chamber to induce environmental stress, this study compared the effect of three lubricant eye drops on various aspects of tear physiology ...
Oksbjerg N - - 2013
Intrauterine growth restriction (IUGR) occurs naturally in pigs and leads to low birth weight of piglets due to under-nutrition caused by placental insufficiency. For two main reasons, low birth weight causes economic loss. First, low birth weight pigs have a greater mortality and increasing the litter size causes more low ...
Raychoudhury R - - 2013
Termites are highly eusocial insects that thrive on recalcitrant materials like wood and soil and thus play important roles in global carbon recycling and also in damaging wooden structures. Termites, such as Reticulitermes flavipes (Rhinotermitidae), owe their success to their ability to extract nutrients from lignocellulose (a major component of ...
Antonen Jaakko - - 2013
A patient with severe capillary leakage syndrome caused by a Puumala hantavirus infection was treated with a single dose of icatibant, a bradykinin receptor antagonist, with a dramatic positive response. We suggest that this drug should be tested in a larger number of patients with severe hantavirus infection.
Shah K K - - 2013
BACKGROUND: Untreated glycogen storage disease (GSD)-1a patients experience hypoglycaemia and growth retardation. The present study examined the effects of dietary interventions on the maintenance of normoglycaemia. METHODS: Clinical trials were identified from EMBASE (January 1980 to November 2011), MEDLINE (January 1948 to November 2011) and the Cochrane Central Register of ...
Sun Peng - - 2013
Avermectins (AVEs), which are widely used for the treatment of agricultural parasitic diseases, belong to a family of a 6,6-spiroketal moiety-containing, macrolide natural products. AVE biosynthesis is known to employ a type I polyketide synthase (PKS) system to assemble the molecular skeleton for further functionalization. It remains unknown how and ...
Tulio F Ribeiro Marco - - 2013
OBJECTIVE: To determine the validity and reproducibility of the Revised Oral Assessment Guide (ROAG) as pre-diagnostic tool used in elderly citizens by community health workers (CHWs) of the Family Health Strategy (FHS). MATERIAL AND METHODS: Initially, we adjusted the English version to Portuguese and then developed a training program for ...
Straiton Melanie L - - 2013
A total of thirty-two women admitted to a general hospital for medical treatment after self-harming completed measures of conventional positive and negative masculinity and femininity. Comparisons were made with two control groups with no self-harm history; 33 women receiving psychiatric outpatient treatment and a nonclinical sample of 206 women. Multinomial ...
Choi Eugene K - - 2013
Purpose:To compare the diagnostic performance of combinations of parameters derived from main hepatic artery (MHA) and intrahepatic artery (IHA) waveforms at Doppler ultrasonography (US), with the aim of developing a systematic approach to the evaluation of the hepatic arteries in orthotopic liver transplants in patients suspected of having hepatic arterial ...
Reid Aylin Y - - 2013
Both early life inflammation and prolonged febrile seizures have been associated with increased excitation in the adult brain. We hypothesized this may be due in part to changes in the cation-chloride cotransporter system. Rat pups received saline or lipopolysaccharide/kainic acid (LPS/KA) resulting in inflammation, followed by a behavioral febrile seizure ...
Mouesca Jean-Marie - - 2013
The main difference between O(2) -sensitive and O(2) -tolerant [NiFe] hydrogenases is the plasticity of the proximal [4Fe3S] cluster in the latter hydrogenase. Deprotonation of a conserved glutamate residue initiates the movement of the iron atom, resulting in its binding to the amide nitrogen atom of one of the two ...
Bolívar J P - - 2013
In order to fill a gap in the open literature, occupational exposures and activity concentrations have been assessed in two NORM industrial plants, located in the south-west of Spain, devoted to the production of mono-ammonium phosphate (MAP) and di-ammonium phosphate (DAP) fertilisers. The annual effective doses received by the workers ...
Frijns Johan H M - - 2013
Abstract Conclusion: Even with six defective contacts, spanning can largely restore speech perception with the HiRes120 speech processing strategy to the level supported by an intact electrode array. Moreover, the sound quality is not degraded. Objectives: Previous studies have demonstrated reduced speech perception scores (SPS) with defective contacts in HiRes120. ...
Rebouças Júlio S - - 2013
In situ (1)H NMR data are reported for 106 Ru(porp)(RSH)(2) species, where porp is the dianion of β-octaethylporphyrin (OEP), meso-tetraphenylporphyrin (TPP), and its para-substituted tetraphenyl analogues (T-p-XPP; X = OMe, Me, F, Cl, CO(2)Me, CF(3)), meso-tetrakis(3,5-dimethylphenyl)porphyrin (T-m,m'-Me(2)PP), and meso-tetramesitylporphyrin (TMP), and R = Me, Et, (n)Pr, (i)Pr, (n)Bu, (t)Bu, (n)Hex, ...
Chan Cheri C Y - - 2013
This article examined the ability of young children to adapt their trust in testimony in relation to the strength of their prior knowledge across 2 cultures and 2 age groups. Kindergartners and second graders in the United States and Hong Kong (N = 128) viewed pictures of objects and made ...
Armstrong Eric N - - 2013
A novel approach, called isothermal isotope exchange (IIE), was applied to varying A- and B-site lanthanum manganites, ferrites, and cobaltites in the perovskite crystal structure in order to extract accurate surface exchange coefficients (k*). Pure electronic conductors revealed temperature dependent isotope exchange, while for mixed ionic and electronic conductors (MIEC) ...
Patra Malay - - 2013
The antischistosomal effect of two [(η(6) -praziquantel)Cr(CO)(3) ] derivatives 1 and 2 was investigated. The compounds (see figure: Cr purple, N blue, O red) are prepared in a one-step procedure from commercially available praziquantel. Both derivatives show a high in vitro activity against Schistosoma mansoni, a parasitic trematode, and had only a minor ...
Factor Sh - - 2013
OBJECTIVES: Antiretroviral (ARV) therapy has prolonged the life expectancy of HIV-infected persons, increasing their risk of age-associated diseases, including atherosclerosis (AS). Decreased risk of AS has been associated with the prevention and control of hypertension (HTN). We conducted a cohort study of perimenopausal women and older men with or at ...
Heyman Gail D - - 2013
The ability of 3- and 4-year-old children to disregard advice from an overtly misleading informant was investigated across five studies (total n = 212). Previous studies have documented limitations in young children's ability to reject misleading advice. This study was designed to test the hypothesis that these limitations are primarily due to ...
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