Search Results
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Wigal Sharon B - - 2013
Abstract Objective: The purpose of this study was to determine the efficacy of NWP06, a novel extended-release (ER) liquid formulation of methylphenidate (MPH), compared with placebo in the treatment of attention-deficit/hyperactivity disorder (ADHD) in children in a laboratory school. Methods: A total of 45 subjects ages 6-12 years were enrolled ...
Pamuk Ferda - - 2013
Background: Aim of this study was to compare gingival changes induced by short and long term tacrolimus and nifedipine administration alone or in combination and to evaluate the expression levels of tumor suppressor phosphatase and tensin homolog (PTEN) in drug-induced gingival enlargement. Methods: Eighty rats were equally divided into eight ...
- - 2013
The BVA officer team and representatives from the Northern Ireland veterinary associations met recently in Belfast to finalise the formation of a BVA Northern Ireland Branch.
Zhang Jinchao - - 2013
The effects of Mn(2+) on the proliferation, osteogenic and adipogenic differentiation of BMSCs were evaluated by employing MTT, ΔΨm, cell cycle, ALP activity, collagen production, ARS and oil red O stain assays. The results indicated that Mn(2+) decreased the viability at most concentrations for 24 h, but the viability was increased ...
Saravanan Vijayakumar - - 2013
Abstract Chloroplasts are organelles found in plant system and other photosynthetic eukaryotes. Since a large number of essential pathways take place in this organelle, proteins in the chloroplast are considered vital. Therefore, knowledge about the subchloroplast localization of the chloroplast proteins will provide precise information in understanding its interaction within ...
Heredia-Jimenez Jose M - - 2013
The aim of this study was to assess the kinematics disorder of gait in men with fibromyalgia. We studied 12 male with fibromyalgia and 14 healthy men. Each participant of the study walked five trials along a 18.6-m walkway. Fibromyalgia patients completed a Spanish version of Fibromyalgia Impact Questionnaire. Significant ...
Nakajima Kiyokazu - - 2013
BACKGROUND: Use of rigid instruments via transvaginal (TV) route has been proposed as a practical alternative to natural orifice translumenal endoscopic surgery (NOTES) using flexible devices. However, its safety has not been fully evaluated for each abdominal organ with different positional relationship to the vagina. The aim of this study ...
de Melo Jociana Bandeira - - 2013
The aim of the present study was to investigate the in vitro effect of CO(2) laser on the inhibition of root surface demineralization around composite resin restorations. For this purpose, 30 blocks obtained from human molar roots were divided into three groups: group 1 (negative control), cavity prepared with cylindrical ...
Raiborg Camilla - - 2013
Endocytosis and subsequent membrane traffic through endosomes are cellular processes that are integral to eukaryotic evolution, and numerous human diseases are associated with their dysfunctions. Consequently, it is important to untangle the molecular machineries that regulate membrane dynamics and protein flow in the endocytic pathway. Central in this context is ...
Ayers Catherine - - 2013
This study presents the perspectives of academic-VA partners who have recently completed a randomized clinical trial within a VA outpatient clinic. The authors reflect on the challenges and rewards of implementing academic-VA community clinical research partnerships with the aim of assisting new VA investigators and VA collaborators. Staff resistance, time ...
Vamanu Emanuel - - 2013
Abstract The antioxidant and antimicrobial properties of two edible mushrooms (Pleurotus ostreatus PBS281009 and Coprinus comatus M8102) were evaluated in this study. The mycelium ethanolic extract obtained in the presence of four different nitrogen sources was investigated with regard to their production of phenolic compounds, β-carotene, lycopene, and their antimicrobial ...
Bian Ruixin - - 2013
By carrying out density functional theory (DFT) calculations, we have studied the effects of silicon (Si)-doping on the geometrical and electronic properties, as well as the chemical reactivity of carbon nanotubes (CNTs). It is found that the formation energies of these nanotubes increase with increasing tube diameters, indicating that the ...
Deleavey Glen F - - 2013
Small interfering RNAs (siRNAs) can trigger potent gene silencing through the RNA interference (RNAi) pathway. The RNA-induced silencing complex (RISC) is key to this targeted mRNA degradation, and the human Argonaute2 (hAGO2) endonuclease component of RISC is responsible for the actual mRNA cleavage event. During RNAi, hAGO2 becomes loaded with ...
Singh Shailendra - - 2013
Calculations of withdrawal time (WT) should be based on colonoscopies where no intervention is performed. Inclusion of procedures with interventional maneuvers, such as polypectomy or biopsy, for estimation of WT can lead to measurement bias and affect the validity of the study.
Hellerbrand Claus - - 2013
Hepatic stellate cells (HSCs) are pericytes of liver in the space between parenchymal cells and sinusoidal endothelial cells of the hepatic lobule. HSCs comprise specialized functions such as vitamin A storage, hemodynamic functions, support of liver regeneration, and immunoregulation. In pathological conditions, HSCs transform to an activated myofibroblasts-like phenotype, start ...
Silva Valter - - 2013
Abstract In 2009, important health organizations met to construct a Joint Scientific Statement (JSS) intended to harmonize the diagnosis of metabolic syndrome worldwide. The JSS aimed to unify the diagnostic criteria of metabolic syndrome, particularly in relation to whether to include abdominal obesity as a criterion of diagnosis. A large ...
Natorska J - - 2013
BACKGROUND: A role of fibrinolysis in the pathogenesis of AS is unknown, although fibrinolytic proteins have been detected in aortic stenotic valves. OBJECTIVE: To investigate whether impaired fibrinolysis could be associated with aortic valve stenosis (AS). METHODS AND RESULTS: We studied 74 patients with AS (43M, 31F, aged 62.7±10.7 years) ...
Lu Yongping - - 2013
In this study, we aimed to prepare a neovascularization-relevant inflammatory cytokine-targeted ultrasound contrast agent and apply it in the ultrasound imaging of atherosclerotic plaque. An interleukin-8 (IL-8) monoclonal antibody was conjugated to SonoVue microbubbles using the N-succinimidyl-3-(2-pyridyldithio)propionate cross-linking method. Then, a prepared IL-8-targeted contrast agent was used for contrast-enhanced ultrasound ...
Demarco Ricardo Cassiano - - 2013
The Cilia represent one of the main mechanisms contributing to the clearance of microorganisms and particles from the respiratory epithelium. Primary ciliary dyskinesia (PCD) is a genetically determined disorder characterized by irreversible systemic dysmotility of the cilia. Secondary ciliary dyskinesia (SCD) differs from primary defects on the reversible ultrastructural alterations ...
Mangia S - - 2013
The results of the study of Xu and colleagues in this issue constitute a critical new piece of information on the functional specialization of astrocytes for K(+) homeostasis in the brain. The relationship between astrocytes and potassium has been long recognized in half a century of research. Now this relation ...
Vaishampayan Ulka - - 2013
Cabozantinib/XL184 (Exelexis, Inc.) has demonstrated remarkable responses in kidney cancer. Preclinical results revealed VEGF, KIT and MET inhibition in a variety of solid tumors such as thyroid, ovarian, renal, lung, liver and prostate cancers. A phase II trial demonstrated efficacy in renal cancer with a 28 % objective response rate, stable ...
Tambuyzer Else - - 2013
This study assessed differences between service users', family carers' and mental healthcare providers' perceptions on service user and family carer involvement in mental healthcare. We conducted questionnaires in care networks for persons with serious and persistent mental illness, among 111 service users, 73 family carers and 216 mental healthcare providers. ...
Li Yan - - 2013
Some recent papers clearly indicate that the cytoplasmic domain of KcsA plays a role in pH sensing. We have performed, for the first time, a targeted molecular dynamics (TMD) simulation of the opening of full-length KcsA at pH 4 and pH 7, with a special interest for the cytoplasmic domain. ...
Roder Friedrich - - 2013
We have established an approach for the spatial control of lipid phase separation in tethered polymer-supported membranes (PSM), which were obtained by vesicle fusion on a PEG polymer brush functionalized with fatty acid moieties. Phase separation of ternary lipid mixtures (DOPC/SM/cholesterol) into liquid disordered (ld) and liquid ordered (lo) phases ...
McRae Jacqui Marie - - 2013
Different molecular structures of grape tannins have been shown to influence astringency, however the in-mouth sensory effects of different molecular structures in red wine tannins remains to be established. The objective of this research was to assess the impact of wine tannin structure on in-mouth sensory properties. Wine tannin was ...
Ninomiya Hironori - - 2013
ABSTRACT: BACKGROUND: A subset of lung adenocarcinomas harboring an EML4-ALK fusion gene resulting in dominant oncogenic activity has emerged as a target for specific therapy. EML4-ALK fusion confers a characteristic histology and is detected more frequently in never or light smokers and younger patients. METHODS: To gain insights into etiology ...
Vila-Costa Maria - - 2013
Bacteria and Archaea of the air-water surface microlayer (neuston) and plankton from three high mountain lakes (Limnological Observatory of the Pyrenees, Spain) were analyzed by 16S rRNA gene 454 pyrosequencing (V6 region) in two dates with different atmospheric aerosol loading conditions: (i) under a Saharan dust plume driven by southern ...
Kim In Sik - - 2013
(S)-(+)-decursin is a biological coumarin compound isolated from Angelica gigas Nakai. (S)-(+)-decursin and its analogue have a variety of pharmacological activities. In the present study, the anti-inflammatory effect of a (S)-(+)-decursin derivative, (S)-(+)-3-(3,4-dihydroxy-phenyl)-acrylic acid 2,2-dimethyl-8-oxo-3,4-dihydro-2H,8H-pyrano [3,2-g]-chromen-3-yl-ester (Compound 6, C6), on in vitro and in vivo atopic dermatitis was investigated. C6 ...
Ojeda-Uribe Mario - - 2013
The use of biological therapies for treating autoimmune diseases is increasing. These therapies are sometimes administered to pregnant women as part of a planned therapeutic regimen or to women with unexpected or unplanned pregnancies. The safety of biological therapies in this setting is a major issue. Here, we describe three ...
Chun Byung-Joon - - 2013
The objective of this study is to determine the efficacy of adding a prokinetic agent to proton pump inhibitors (PPI) for the treatment of laryngopharyngeal reflux (LPR) disease. A prospective, randomized open trial comparing lansoprazole plus itopride to lansoprazole single therapy was performed for 12 weeks. Sixty-four patients with a reflux ...
Fumagalli Romario Uberto - - 2013
BACKGROUND: Transabdominal preperitoneal (TAPP) repair is widely used to treat bilateral or recurrent inguinal hernias. Recently a self-gripping mesh has been introduced into clinical practice. This mesh does not need staple fixation and thus might reduce the incidence of chronic pain. This prospective study aimed to compare two groups of ...
Kalra Sanjay - - 2013
Abstract Background: Individual sulfonylurea agents differ in pharmacokinetic properties and clinical effects. This study aimed to describe the usage pattern, glycemic improvement, hypoglycemia, and change in body mass index (BMI) observed with commonly used sulfonylureas. Subjects and Methods: Patients of either gender with type 2 diabetes mellitus (T2DM), between 18 ...
Zhao Gaiping - - 2013
The present work formulates and analyzes the inhibitory effect of anti-angiogenic factor angiostatin excreted by the primary tumor on metastatic tumor angiogenesis, blood perfusion, and interstitial fluid flow in the tumor microenvironment by means of a numerical experiment. The simulation results demonstrate that angiostatin has an obvious impact on the ...
Anitua Eduardo - - 2013
Background: Regeneration of periodontal tissues is one of the most important goals for the treatment of periodontal disease. The technology of plasma rich in growth factors provides a biological approach for the stimulation and acceleration of tissue healing. The purpose of this study was to evaluate the biological effects of ...
Souza Marcy J - - 2013
Approximately 5.4 million cubic yards of coal fly ash and water spilled into the Emory River embayment of Watts Bar Reservoir in east Tennessee on Dec 22, 2008. Raccoons were collected in 2009 and 2010 from the spill site (10/y) and unexposed areas (5/y) to determine whether metals and metalloids ...
Lien Huang-Chun - - 2013
Phyllodes tumors (PTs) are characterized by co-proliferation of the stroma and epithelium, with the stroma being the neoplastic element. Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) is a deubiquitinating enzyme that was originally considered to be a neuronal-specific marker, but later reports have shown both tumorigenic and antitumorigenic roles for UCHL1. Although ...
Chen Yue Long - - 2013
A naringinase from Aspergillus aculeatus JMUdb058 was purified, identified and characterized. This naringinase had a molecular mass (MW) of 348 kDa and contained four subunits with MWs of 100 kDa, 95 kDa, 84 kDa and 69 kDa. Mass spectrometric analysis revealed that the three larger subunits were β-D-glucosidases and that ...
Shirzadi Ali - - 2013
PURPOSE: Hemangiopericytoma (HPC) is a rare tumor of the central nervous system. Primary spinal occurrence of this tumor is extremely uncommon and cases involving the intramedullary spinal cord are even more rare. The purpose of this study was to explore the clinical features, surgical strategies, outcome and pathology in a ...
Masumori K - - 2013
BACKGROUND: The aim of the present study was to classify the short-term outcomes of local correction of stoma prolapse with a stapler device. METHODS: The medical records of 11 patients undergoing local correction of stoma prolapse using a stapler device were retrospectively reviewed. RESULTS: No mortality or morbidity was observed ...
Weir Brad - - 2013
We introduce an implicit method for state and parameter estimation and apply it to a stochastic ecological model. The method uses an ensemble of particles to approximate the distribution of model solutions and parameters conditioned on noisy observations of the state. For each particle, it first determines likely values based ...
Kreeftmeijer-Vegter Annemarie Rosan - - 2013
Objective: To develop an oral solid dosage form of levamisole suitable for the paediatric population in terms of dose accuracy, palatability, stability and ease of administration. Methods: Small undividable tablets (Ø5 - 8 mm) in four different strengths were manufactured to allow for flexible and accurate dosing. In vitro dissolution ...
Han Lianhuan - - 2013
Substrate leveling is an essential but neglected instrumental technique of scanning electrochemical microscopy (SECM). In this technical note, we provide an effective substrate leveling method based on the current feedback mode of SECM. By using an air-bearing rotary stage as the supporter of electrolytic cell, the current feedback presents a ...
Erthal Vanessa - - 2013
Laser acupuncture is a modality of low-level light therapy used as an alternative to needling for the past three decades. Although it has proved effective for the treatment of various conditions, the mechanisms underlying its effects are not fully understood. To contribute to this understanding, this study was designed to ...
Mantel Frederick - - 2013
ABSTRACT: Although locoregional relapse is frequent after definitive radiotherapy (RT) or multimodal treatments, re-irradiation is only performed in few patients even in palliative settings like e.g. vertebral metastasis. This is most due to concern about potentially severe complications, especially when large volumes are exposed to re-irradiation. With technological advancements in ...
Kim Sunghoon - - 2013
Evaluation of gap length is an important part of preoperative assessment of esophageal atresia (EA) without distal tracheoesophageal fistula. A technique of measuring the esophageal gap in isolated EA using carbon dioxide gas insufflation of the stomach through a port and a laparoscope is described.
Mustafa Ayman G - - 2013
PURPOSE: The study aims to investigate anatomy learning styles and strategies of Jordanian and Malaysian medical students at the Jordan University of Science and Technology. METHODS: The study is a cross-sectional questionnaire-based study. Students' responses for the questionnaire were numerically coded, and the results were analyzed to reveal statistically significant ...
Burkhart Richard A - - 2013
BACKGROUND: The overall complication rate after pancreaticoduodenectomy (PD) approaches 50 %, with anastomotic failure being the most frequent cause of serious postoperative morbidity. Hepaticojejunostomy leaks (also called bile leaks) are the second most common type of leak, behind pancreaticojejunostomy leaks, yet have been the focus of only a single study as ...
Fernandes Ricardo J - - 2013
Pinna et al. (J Physiol Sci, 10.1007/s12576-012-0226-7, 2012) showed that a tethered swimming incremental protocol leads to higher maximal oxygen consumption values than during cycle ergometer and arm-crank tests, and evidenced that anaerobic threshold occurred at higher workloads during swimming comparing to other types of exercise. This is an interesting ...
- - 2013
The following information has been produced for Veterinary Record by the Veterinary Medicines Directorate (VMD) to provide an update for veterinary surgeons on recent changes to marketing authorisations for veterinary medicines in the UK and on other relevant issues.
Winter Corinna C - - 2013
BACKGROUND: While research on exercise interventions during anticancer treatment is well-established in adults, only very few studies exist in children. However, pediatric patients experience great limitations to being physically active, and appropriate interventions are desired. PROCEDURE: The present study aimed at investigating the effects of individualized exercise interventions during inpatient ...
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