Search Results
Results 451 - 500 of 3975
< 5 6 7 8 9 10 11 12 13 14 15 >
Telezhkin Vsevolod V Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, WC1E 6BT, - - 2013
All Kv7 potassium channels require membrane phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) for their normal function and hence can be physiologically regulated by neurotransmitters and hormones that stimulate phosphoinositide hydrolysis. Recent mutational analysis indicates that a cluster of basic residues in the proximal C-terminus (K354/K358/R360/K362) is crucial for PI(4,5)P2 activation of cardiac Kv7.1 channels. ...
- - 2013
To identify susceptibility loci for visceral leishmaniasis, we undertook genome-wide association studies in two populations: 989 cases and 1,089 controls from India and 357 cases in 308 Brazilian families (1,970 individuals). The HLA-DRB1-HLA-DQA1 locus was the only region to show strong evidence of association in both populations. Replication at this ...
Cregg Roman R Molecular Nociception Group, Wolfson Institute for Biomedical Research, UCL, Gower Street, London WC1E 6BT, - - 2013
We identified and clinically investigated two patients with primary erythromelalgia mutations (PEM), which are the first reported to map to the fourth domain of Nav1.7 (DIV). The identified mutations (A1746G and W1538R) were cloned and transfected to cell cultures followed by electrophysiological analysis in whole-cell configuration. The investigated patients presented ...
Moeendarbary Emad E London Centre for Nanotechnology, University College London, London, - - 2013
The cytoplasm is the largest part of the cell by volume and hence its rheology sets the rate at which cellular shape changes can occur. Recent experimental evidence suggests that cytoplasmic rheology can be described by a poroelastic model, in which the cytoplasm is treated as a biphasic material consisting ...
Satish Latha L Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA 15213, - - 2013
Dupuytren's contracture (DC) is a fibroproliferative disorder of unknown etiology characterized by a scar-like contracture that develops in the palm and/or digits. We have previously reported that the eta subunit of the chaperonin containing T-complex polypeptide (CCT-eta) is increased in fibrotic wound healing, and is essential for the accumulation of ...
Xu Rong R Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Avenue, Houston, Texas 77030, - - 2013
The ataxia-telangiectasia mutated (ATM) protein plays a central role in DNA damage response and cell cycle checkpoints, and may be a promising target for cancer therapy if normal tissue toxicity could be avoided. The strategy presented here to target ATM for breast cancer therapy involves the use of liposomal-encapsulated, gene-specific ...
Hassan Hanaa A HA Physiology Division, Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt, - - 2013
The present study aims to investigate the adverse effects of plant growth regulators : gibberellic acid (GA3) and indoleacetic acid (IAA) on testicular functions in rats, and extends to investigate the possible protective role of grape seed extract, proanthocyanidin (PAC). Male rats were divided into six groups; control group, PAC, ...
Cho Young-Seok YS Emory University School of Medicine, Atlanta, GA 30322, - - 2013
Molecular therapy using a small interfering RNA (siRNA) has shown promise in the development of novel therapeutics. Various formulations have been used for in vivo delivery of siRNAs. However, the stability of short double-stranded RNA molecules in the blood and efficiency of siRNA delivery into target organs or tissues following ...
Tian Wei - - 2013
The gain of E-cadherin and loss of Vimentin known as "Cadherin switching" resulting in epithelial differentiation play an important role in tumor cell invasion and metastasis. In soft tissue leiomyosarcoma (LMS), aberrant expression of E-cadherin and down-regulation of Vimentin-related Mesenchymal to Epithelial Reverting Transition was defined, but the role of ...
Valentiny Christine - - 2013
A 75-year-old female patient presented with late relapse of acute myeloid leukemia (AML). She received a single cycle of azacitidine before refusing further treatment. Around 6 weeks after this single azacitidine cycle, complete remission-according to international working group criteria-was observed with continuous improvement in peripheral blood counts to normal values, ...
Jeon Ok-Cheol - - 2013
PURPOSE: Since the absorption of ceftriaxone (CTO) in the intestine is restricted by its natural physiological characteristics, we developed a series of small synthetic compounds derived from bile acids to promote the absorption of CTO in the gastrointestinal tract. METHODS: Several bile acid derivatives were screened by measuring water solubility ...
Apablaza P - - 2013
AIMS: Describing the genetic relationship between isolates of Flavobacterium psychrophilum with a main emphasis of samples from Chile and Norway. The isolates have been obtained from farmed salmonids in Norway and Chile, and from wild salmonids in Norway, but isolates from North America and European countries are also included in ...
D'Annibale Annibale - - 2013
BACKGROUND: Long-term data from the CLASICC study demonstrated the oncologic equivalence of laparoscopic and open rectal cancer surgery despite an increased circumferential resection margin involvement in the laparoscopic group in the initial report. Moreover, laparoscopic total mesorectal excision (TME) may be associated with increased rates of male sexual dysfunction compared ...
Santos Byron F - - 2013
BACKGROUND: The optimal strategy to manage intraoperative hemorrhage during NOTES(®) is unknown. A randomized comparison of three instruments for hemorrhage control was performed [prototype endoscopic bipolar hemostasis forceps (BELA) vs. prototype endoscopic clip (E-CLIP) applier versus laparoscopic clip (L-CLIP) applier]. METHODS: A hybrid transvaginal NOTES model in swine was used, ...
Hornok Sándor - - 2013
Abstract The aim of this study was to analyze synanthropic birds as risk factors for introducing ticks and tick-borne pathogens into human settlements, with an emphasis on rickettsiae. Altogether 184 subadult ticks were found on 5846 birds. Tick infestation was most prevalent during the spring. In this sample group the ...
Rinaldi Maurizio - - 2013
Saccharomyces cerevisiae is best known as the baker's and brewer's yeast, but its residual traces are also frequent excipients in some vaccines. Although anti-S. cerevisiae autoantibodies (ASCAs) are considered specific for Crohn's disease, a growing number of studies have detected high levels of ASCAs in patients affected with autoimmune diseases ...
Nellen R G L - - 2013
Mal de Meleda, (MDM, OMIM #248300) is an autosomal recessive monogenic disorder defined by progressive transgredient hyperkeratosis of the palms and soles, hyperhidrosis, malodourous scent due to bacterial superinfection, and minor symptoms such as perioral erythema, mild ichthyosis, pseudo-ainhum and nail abnormalities. Mutations in the SLURP1 gene, encoding the Secreted ...
Su Yuan - - 2013
Background: Recent studies indicated that the chronic low-grade inflammation induced by periodontitis is related to obesity and type 2 diabetes mellitus (T2DM). The purpose of this study is to investigate the effects of periodontitis on the obesity-related adipose tissue inflammation and thereby systemic insulin resistance in a rat model. Methods: ...
Nuttall Tim - - 2013
Tim Nuttall discusses some factors to consider when interpreting the results of antimicrobial susceptibility tests.
Ferreira Gilson Rodrigues - - 2013
In this study, Raman, infrared, UV/Vis, NMR and single crystal X ray diffraction spectroscopies are used to elucidate the tautomeric equilibrium of azo dyes derived from 1-phenyl-azo-2-naphthol (Sudan I). A new crystallographic structure is described for Sudan I revealing the presence of intramolecular hydrogen bonds and supramolecular interactions, such as ...
Karavasilis Vasilios - - 2013
We undertook this phase I study to investigate the feasibility of the combination of temozolomide (TMZ) and lapatinib (LP) and to define the maximum tolerated dose (MTD) of LP in patients with relapsed high-grade gliomas. Eligible patients were enrolled in this dose escalation study of LP. TMZ was administered at ...
Wong P - - 2013
Thalassemia bone disease is well described, but the prevalence of nephrolithiasis has not been characterized. The association between nephrolithiasis, reduced bone density, and increased fractures has been demonstrated through this retrospective study of 166 participants with transfusion-dependent thalassemia. The findings support the need for increased vigilance of kidney and bone ...
Renault P E - - 2013
Alcoholic fermentation of grape must is a complex process, involving several yeast genera and species. The early stages in fermentation are dominated by non-Saccharomyces yeasts that are gradually replaced by the Saccharomyces cerevisiae species, which takes over the fermentation. Quantitative studies have reported the influence of non-Saccharomyces yeast species on ...
Oleinik Anton - - 2013
Scientific communication takes place at two registers: first, interactions with colleagues in close proximity-members of a network, school of thought or circle; second, depersonalised transactions among a potentially unlimited number of scholars can be involved (e.g., author and readers). The interference between the two registers in the process of peer ...
Karkouche R - - 2013
Renal lymphangiomatosis is an extremely rare disease characterized by developmental malformation of the lymphatic system surrounding the kidneys. We present the case of a 22-year-old pregnant female discovered because of worsening. Ultrasound, computed tomography, and magnetic resonance imaging studies were performed. An 18 × 11 × 10 cm voluminous cystic subcapsular lesion compressing the left ...
Mechelke Martin - - 2013
Protein chemical shifts encode detailed structural information that is di_cult and computationally costly to describe at a fundamental level. Statistical and machine learning approaches have been used to infer correlations between chemical shifts and secondary structure from experimental chemical shifts. These methods range from simple statistics such as the chemical ...
Sigamani Elanthenral - - 2013
PURPOSE: 11p13 and 11p15 loss of heterozygosity (LOH) in Wilms tumor (WT), the commonest molecular pathogenetic event in WT, shows variation in different parts of the world. The present study looked for the presence of 11p13 and 11p15 LOH as well as nephrogenic rests in WT occurring in India. METHOD: ...
Chia Audrey - - 2013
BACKGROUND: The aims of this study were to determine the longitudinal effects of myopia on full-field electroretinogram (ffERG) in children, and whether there were any effects due to atropine treatment. METHODS: Fifty children, enrolled in the atropine treatment for myopia study, were randomly selected and 35 children consented to undergo ...
Mason Julie L - - 2013
The National Cancer Institute (NCI) career development (K) awards program supports investigators to develop their cancer research programs and achieve independence. The NCI Center for Cancer Training conducted a K program evaluation by analyzing outcomes of awardees and individuals who applied to the program but were not funded. The evaluation ...
Minakata Kenji - - 2013
It is well recognized that poor perioperative blood glucose (BG) control can increase the risk of infection, cardiovascular accidents, and even death in patients undergoing cardiac surgery. Since it has been reported that tight BG control (80-110 mg/dL) yields better outcomes in critically ill patients, it became a standard of care ...
Chen Yi-Ping - - 2013
ABSTRACT: We developed mesoporous silica nanoparticle (MSN) as a multifunctional vehicle for enzyme delivery. Enhanced transmembrane delivery of a superoxide dismutase (SOD) enzyme embedded in MSN was demonstrated. Conjugation of the cell-penetrating peptide derived from the human immunodeficiency virus 1 (HIV) transactivator protein (TAT) to mesoporous silica nanoparticle is shown ...
Zhang Manhua - - 2013
Helicobacter hepaticus and Helicobacter pylori both belong to Helicobacter species. Strains of Lactobacillus acidophilus, including L4 and L6, have shown significant inhibitory effects on H. pylori. Based on this phenomenon, we aim to investigate the inhibitory effect of L. acidophilus on H. hepaticus. Both standard and isolated H. hepaticus strains ...
Gulitz Anna - - 2013
AIMS: The aim of this study was to analyse the bacterial microbiota of water kefir using culture-independent methods. METHODS AND RESULTS: We compared four water kefirs of different origins using 16S rDNA amplicon sequencing and ARDRA. The microbiota consisted of different proportions of the genera Lactobacillus (Lb.), Leuconostoc (Lc.), Acetobacter ...
Annandale C H - - 2013
It is known that lumpy skin disease virus (LSDV) can be shed in bull semen following infection and also that artificial insemination (AI) poses a biosecurity risk. However, it is not known whether the use of LSDV infected semen in AI poses a biosecurity risk. The aim of this study ...
Skottun B C - - 2013
Isoluminant (or equiluminant) color stimuli (i.e., those that contain variations only in chromaticity) have been employed in attempts to separate magno- and parvocellular responses in psychophysical and noninvasive electrophysiological experiments. The justification for this has been the assumption that magnocellular cells, unlike parvocellular neurons, do not respond to stimuli varying ...
Li Xin-Lan - - 2013
Abstract An outbreak of fever and meningitis/encephalitis occurred in Xinjiang, China, from August 5 to September 3, 2004. In preliminary diagnostic testing, several cerebrospinal fluid (CSF) and serum samples showed positive immunoglobulin M (IgM) antibody to Japanese encephalitis virus. Here, the CSF and serum samples of 6 cases collected at ...
Lemanu Daniel P - - 2013
BACKGROUND: This systematic review aims to investigate the extent to which preoperative conditioning (PREHAB) improves physiologic function and whether it correlates with improved recovery after major surgery. METHODS: An electronic database search identified randomized controlled trials (RCTs) investigating the safety and efficacy of PREHAB. The outcomes studied were changes in ...
Ravindranath Kapu - - 2013
OBJECTIVE: The purpose of this study is to understand the epidemiology, clinical features, behavior, and the prognostic factors that influence the outcome of intracranial meningiomas in children. METHODS: Thirty-one patients with age less than 18 years who underwent surgery for intracranial meningiomas during the period of at 1988-2012 at Voluntary Health ...
Kang Bo - - 2013
Auxin plays a pivotal role in many facets of plant development. It acts by inducing the interaction between auxin-responsive (AUX/IAA) proteins and the ubiquitin protein ligase SCF(TIR) to promote the degradation of the AUX/IAA proteins. Other cofactors and chaperones that participate in auxin signaling remain to be identified. Here, we ...
Iester Michele - - 2013
Abstract Purpose: Supposedly, prostaglandin analogs (PGA) could reduce the central corneal thickness (CCT), while topical carbonic anhydrase inhibitors (TCAI) could increase CCT. The aim of the study was to evaluate clinically significant CCT effects in patients treated with PGA or TCAI. Methods: At least 50 glaucomatous patients were saved on ...
- - 2013
The Working Time Regulations (1998), particularly in terms of 24-hour emergency cover, continue to cause confusion. The BVA has put together a myth-busting webpage -- accessible via www.bva.co.uk/guides - highlighting the key provisions that are relevant to vets working in private practice.
Doster Anne - - 2013
Re-expression of RAG in mature B cells may support autoreactivity by enabling revision of the B cell receptor (BCR). Recent reports suggest that administration of Toll-like receptor (TLR)-9-stimulating CpG oligodeoxynucleotides (ODN) could trigger manifestation of autoimmune disease and that TLR are involved in the selection processes eliminating autoreactive BCR. The ...
Ouyang Yabo - - 2013
ABSTRACT: BACKGROUND: HIV-1 subtype B' isolates have been predominantly circulating in China. Their intra- and inter-subtype neutralization sensitivity to autologous and heterologous plasmas has not been well studied. RESULTS: Twelve HIV-1 B' clinical isolates obtained from patients were tested for their intra- and inter-subtype neutralization sensitivity to the neutralization antibodies ...
Chen Chung-Yu - - 2013
Melanoma is one of the most chemoresistant cancers in patient care. The remission rate of current therapy remains low. DC-81, an antitumor antibiotic produced by Streptomyces species, belongs to pyrrolo[2,1-c][1,4]benzodiazepine (PBD), which is a potent inhibitor of nucleic acid synthesis. An enediyne contains either DNA intercalating groups or DNA minor ...
Ashraf Muhammad Aqeel - - 2013
Field and laboratory studies were conducted to estimate concentration of potential contaminants from landfill in the underlying groundwater, leachate, and surface water. Samples collected in the vicinity of the landfill were analyzed for physiochemical parameters, organic contaminants, and toxic heavy metals. Water quality results obtained were compared from published data ...
Wu Chongde - - 2013
The aim of this study was to investigate the effect of aspartate on the acid tolerance of L. casei. Acid stress induced the accumulation of intracellular aspartate in L. casei, and the acid-resistant mutant exhibited 32.5 % higher amount of aspartate than that of the parental strain at pH 4.3. Exogenous aspartate ...
Glassey Jarka - - 2013
The advances in measurement techniques, the growing use of high-throughput screening and the exploitation of 'omics' measurements in bioprocess development and monitoring increase the need for effective data pre-processing and interpretation. The multi-dimensional character of the data requires the application of advanced multivariate data analysis (MVDA) tools. An overview of ...
Serapiao-Moraes Diana F - - 2013
PURPOSE: This study aimed to evaluate the role of caffeine chronic administration during gestation of C57BL/6 mice on cardiac remodeling and the expression of components of the renin-angiotensin system (RAS) in male offspring as adults. METHODS: Pregnant C57BL/6 female mice were divided into two groups (n = 10): Control group (C), dams ...
Li M - - 2013
BACKGROUND: Ichthyosis vulgaris (IV; OMIM 146700) is a very common inherited skin disorder. Loss-of-function mutations in filaggrin gene (FLG) have been identified as the cause of IV. In the previous study, we found that the percentage of FLG null mutations in atopic dermatitis (AD) associated IV was lower than that ...
Eastman Amy - - 2013
BACKGROUND: Compared with other breast cancer subtypes, triple negative breast cancers (TNBC) are associated with higher recurrence rates and worse survival. Because of the aggressive nature of TNBC, outcomes may be more sensitive to delays in time to treatment. This study evaluates whether delays from diagnosis to initial treatment in ...
< 5 6 7 8 9 10 11 12 13 14 15 >