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Clendenning Mark M Cancer and Population Studies, Queensland Institute of Medical Research, 300 Herston Road, Herston, QLD, 4006, Australia, - - 2013
Current screening practices have been able to identify PMS2 mutations in 78 % of cases of colorectal cancer from the Colorectal Cancer Family Registry (Colon CFR) which showed solitary loss of the PMS2 protein. However the detection of large-scale deletions in the 3' end of the PMS2 gene has not ...
Vallier Heather A HA Department of Orthopaedic Surgery, MetroHealth Medical Center, Cleveland, OH 44109, USA. - - 2013
We hypothesized that early definitive management (within 24 hours of injury) of mechanically unstable fractures of the pelvis, acetabulum, femur and spine would reduce complications and shorten length of stay. Retrospective review. Level 1 trauma center. 1005 skeletally mature patients with Injury Severity Score (ISS) ≥18 with pelvis (n = ...
O'Gorman Susan M SM Mayo Clinic, Rochester, MN 55905, - - 2013
Obstructive sleep apnea has been associated with postoperative complications. We hypothesized that postoperative autotitrating positive airway pressure (APAP) applied to patients at high risk for obstructive sleep apnea would shorten hospital stay and reduce postoperative complications. Included were patients aged 18 to 100 years scheduled for elective total knee or ...
Zaltz Ira I Department of Orthopaedic Surgery, William Beaumont Hospital, Royal Oak, MI 48073, USA. - - 2013
The treatment of unstable slipped capital femoral epiphysis (SCFE) is rapidly evolving with the ability to correct epiphyseal alignment using the modified Dunn technique. Adopting a new treatment method depends on confirming that it achieves its goals, produces few, nonserious complications with no lasting sequelae, and improves the natural history ...
Chien Jung-Yien JY Chest Hospital, Department of Health, Executive Yuan, Tainan, - - 2013
Sputum samples from patients with non-multidrug-resistant (non-MDR) pulmonary TB may remain smear-positive for acid-fast bacilli (AFB) at the fifth month of anti-TB treatment. However, its significance remains unknown. From January 2004 to April 2009, there were 5,403 patients with culture-confirmed pulmonary TB from four hospitals in Taiwan. Among them, 116 ...
Olson Steven A SA Department of Orthopaedic Surgery, Duke University School of Medicine, DUMC Box 3389, Durham, NC 27710, USA. - - 2013
Orthopaedic surgery practices can provide substantial value to healthcare systems. Increasingly, healthcare administrators are speaking of the need for alignment between physicians and healthcare systems. However, physicians often do not understand what healthcare administrators value and therefore have difficulty articulating the value they create in discussions with their hospital or ...
Gauss Julie W JW College of Osteopathic Medicine, Michigan State University, East Lansing, MI, - - 2013
Understanding women's psychological barriers to getting Papanicolaou (Pap) screening has potential to impact cancer disparities. This study examined pain perceptions of Pap testing among black, Latina, and Arab women and goal setting to receive Pap tests. Data on 420 women, in a longitudinal study, were analyzed using Chi-square tests of ...
Doelken Peter P Division of Pulmonary and Critical Care Medicine, Albany Medical College, Albany, NY 12208, USA. - - 2013
In individual patients, especially those who are hospitalized, several conditions often coexist that may be responsible for the development of a pleural effusion and may affect the pleural fluid analysis (PFA). The objective of this study was to investigate the effects of end-stage renal disease and pneumonia on PFA in ...
Marshall Rebecca R Department of Psychiatry, Oregon Health and Science University, Portland, OR, - - 2013
The Patient Activation Measure (PAM) assesses several important concepts in chronic care management, including self-efficacy for positive health behaviors. In HIV-infected populations, better self-efficacy for medication management is associated with improved adherence to antiretroviral medications (ARVs), which is critically important for controlling symptoms and slowing disease progression. To determine 1) ...
Vajro Pietro P Department of Medicine and Surgery, University of Salerno Medical School, Salerno, Italy. - - 2013
A specific bacterial gut microbiota profile with increased extraction of energy has recently been associated with obesity, which has been shown to be a transmissible phenotype by microbiota transplantation. At the same time, there is now increasing evidence that gut microbiota plays a role in the development of hepatic steatosis ...
Okupa Adesua Y AY University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA. - - 2013
Presently, there is insufficient information to compare the value of daily diaries vs retrospective questionnaires for assessing symptoms in relationship to asthma control in clinical trials. Daily symptom diaries are often burdensome to gather, incomplete, susceptible to fabrication, and of questionable reliability. There is also concern that retrospective symptom questionnaires ...
Pimenta Eduardo E Endocrine Hypertension Research Centre and Clinical Centre of Research Excellence in Cardiovascular Disease and Metabolic Disorders, The School of Medicine, The University of Queensland, Princess Alexandra and Greenslopes Private Hospitals, Brisbane, QLD, - - 2013
Obstructive sleep apnea (OSA) is a strong and independent risk factor for the development of hypertension, particularly resistant hypertension, and cardiovascular diseases. Patients with resistant hypertension have a high prevalence of OSA in association with elevated aldosterone levels, high salt intake, and salt-sensitive BP. The objective of this study was ...
Mackner Laura M LM Center for Biobehavioral Health, Nationwide Children's Hospital, Columbus, OH, USA. - - 2013
Pediatric inflammatory bowel disease (IBD) can affect many areas of psychosocial functioning, and comprehensive medical care includes consideration of psychosocial issues as well as disease factors. The purpose of this clinical report is to review research on psychosocial functioning in pediatric IBD and to provide recommendations for care providers in ...
Kaftanovskaya Elena M EM Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, - - 2013
A significant number of patients with germline mutations in the Wilms' tumour 1 (WT1) gene, a transcriptional factor essential for early renal and gonadal development, display cryptorchidism or non-scrotal testis position. We show here that WT1 is expressed during development in the mouse gubernacular ligament connecting the testis to the ...
Kobos Rachel R Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, - - 2013
Oncogenic rearrangements of the TFE3 transcription factor gene are found in two distinct human cancers. These include ASPSCR1-TFE3 in all cases of alveolar soft part sarcoma (ASPS) and ASPSCR1-TFE3, PRCC-TFE3, SFPQ-TFE3 and others in a subset of paediatric and adult RCCs. Here we examined the functional properties of the ASPSCR1-TFE3 ...
Tobar-Rubin Raquel R Department of Biological Science, Benedictine University, Lisle, Illinois 60532, - - 2013
McCune-Albright syndrome (MAS) is a human genetic disorder caused by a mutation that constitutively activates the G(s)α subunit by abolishing GTP hydrolysis. MAS patients suffer from a range of endocrinopathies as well as polyostotic fibrous dysplasia of bone. We previously identified an intragenic suppressor of the MAS mutation in a ...
Roy Joannie J Maisonneuve-Rosemont Hospital, University of Montreal, Montreal, - - 2013
Promoting axon regeneration following injury is one of the ultimate challenges of neuroscience, and understanding the mechanisms that regulate axon growth and guidance is essential to achieve this goal. During development axons are directed over relatively long distances by a precise extracellular distribution of chemical signals in the embryonic nervous ...
Simmons Chelsey S CS Department of Mechanical Engineering and Cardiovascular Institute, Stanford University, 496 Lomita Mall, Durand Building Room 223, Stanford, CA, - - 2013
Cells that line major tissues in the body such as blood vessels, lungs and gastrointestinal tract experience deformation from mechanical strain with our heartbeat, breathing, and other daily activities. Tissues also remodel in both development and disease, changing their mechanical properties. Taken together, cells can experience vastly different mechanical cues ...
Belinsky Glenn S GS Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, - - 2013
We tested whether dopaminergic drugs can improve the protocol for in vitro differentiation of H9 human embryonic stem cells (hESCs) into dopaminergic neurons. The expression of 5 dopamine (DA) receptor subtypes (mRNA and protein) was analyzed at each protocol stage (1, undifferentiated hESCs; 2, embryoid bodies [EBs]; 3, neuroepithelial rosettes; ...
Beekman Marian M Molecular Epidemiology, Leiden University Medical Centre, Leiden, ZC, 2333, The Netherlands. - - 2013
Clear evidence exists for heritability of human longevity, and much interest is focused on identifying genes associated with longer lives. To identify such longevity alleles, we performed the largest genome-wide linkage scan thus far reported. Linkage analyses included 2118 nonagenarian Caucasian sibling pairs that have been enrolled in 15 study ...
Mehta Angad P AP Department of Chemistry, Texas A&M University, College Station, TX 77842, - - 2013
MoaA, a radical S-adenosylmethionine enzyme, catalyzes the first step in molybdopterin biosynthesis. This reaction involves a complex rearrangement in which C8 of guanosine triphosphate is inserted between C2' and C3' of the ribose. This study identifies the site of initial hydrogen atom abstraction by the adenosyl radical and advances a ...
Meinel Felix G - - 2013
The objective of this study was to determine whether automated quantification of lung perfused blood volume (PBV) in dual-energy computed tomographic pulmonary angiography (DE-CTPA) can be used to assess the severity and regional distribution of pulmonary hypoperfusion in emphysema. We retrospectively analyzed 40 consecutive patients (mean age, 67 [13] years) ...
Umino Yumiko - - 2013
Diabetes reduces retinal and visual sensitivity to dim light flashes. However, the impact of diabetes on contrast sensitivity in dim light is unknown. Based on the lowered visual sensitivity previously observed, we hypothesized that contrast sensitivity would similarly be reduced. We therefore examined scotopic contrast sensitivity of the optomotor response ...
Richdale Kathryn - - 2013
To calculate age-related and per diopter (D) accommodative changes in crystalline lens and ciliary muscle dimensions in vivo in a single cohort of emmetropic human adults ages 30 to 50 years. The right eyes of 26 emmetropic adults were examined using ultrasonography, phakometry, anterior segment optical coherence tomography, and high ...
Siniscalchi Antonio - - 2013
Dysaesthetic pain is a common neuropathic pain in patients with multiple sclerosis. Both tricyclic antidepressants (i.e., amitriptyline and duloxetine) and antiepileptic drugs (i.e., carbamazepine, gabapentin and pregabalin) represent first-line treatment of neuropathic pain. However, topiramate, an antiepileptic drug, also demonstrated clinical efficacy in these patients. In this report we describe ...
Sankar Jhuma J Department of Pediatrics, PGIMER, DR RML Hospital, New Delhi, India. - - 2013
Our objective was to evaluate the effect of interventions in the initial period of stabilization (i.e., at 4 hrs) on the predictive ability of Pediatric Index of Mortality and Pediatric Index of Mortality-2 scores and to evaluate their performance in our ICU. Prospective observational study. PICU of a tertiary care ...
Robinson Cliff G CG Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri 3110, USA. - - 2013
The purpose of this study was to compare patterns of failure between lobar resection (lobectomy or pneumonectomy) and stereotactic body radiation therapy (SBRT) for patients with clinical stage I non-small-cell lung cancer (NSCLC). From January 2004 to January 2008, 338 patients underwent definitive treatment for pathologically confirmed clinical stage I ...
Boyton R J RJ Lung Immunology Group, Section of Infectious Diseases and Immunity, Hammersmith Campus, Department of Medicine, Centre for Respiratory Infection, Imperial College London, UK. - - 2013
Recent studies analysing immunogenetics and immune mechanisms controlling susceptibility to chronic bacterial infection in bronchiectasis implicate dysregulated immunity in conjunction with chronic bacterial infection. Bronchiectasis is a structural pathological end-point with many causes and disease associations. In about half of cases it is termed idiopathic, because it is of unknown ...
Barcala Tabarrozzi A E AE Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA), CONICET, Instituto Partner de la Sociedad Max Planck, Buenos - - 2013
Type 1 diabetes mellitus (T1DM) results from death of insulin-secreting β cells mediated by self-immune cells, and the consequent inability of the body to maintain insulin levels for appropriate glucose homeostasis. Probably initiated by environmental factors, this disease takes place in genetically predisposed individuals. Given the autoimmune nature of T1DM, ...
Hancock D G DG Centenary Institute of Cancer Medicine and Cell Biology and the Discipline of Dermatology, University of Sydney, Sydney, NSW, - - 2013
The dendritic cell (DC) lineage is remarkably heterogeneous. It has been postulated that specialized DC subsets have evolved in order to select and support the multitude of possible T cell differentiation pathways. However, defining the function of individual DC subsets has proven remarkably difficult, and DC subset control of key ...
Brooks-Worrell B M BM Department of Medicine, VA Puget Sound Health Care System, Seattle, WA 98108, USA. - - 2013
The clinical efficacy of peroxisome proliferator-activated receptor gamma (PPAR-γ) agonists in cell-mediated autoimmune diseases results from down-regulation of inflammatory cytokines and autoimmune effector cells. T cell islet autoimmunity has been demonstrated to be common in patients with phenotypic type 2 diabetes mellitus (T2DM) and islet-specific T cells (T(+) ) to ...
Gouilleux-Gruart V V CNRS UMR 7292, Université François Rabelais, CHRU de Tours, Tours, - - 2013
Treatment of common variable immunodeficiency disorders (CVID) is based on replacement therapy using intravenous (i.v.) or subcutaneous (s.c.) immunoglobulin (Ig)G. Interindividual variation of IgG dose is common. A total of 380 CVID patients on stable IgG replacement from two prospective cohorts were analysed. An 'efficiency' index was defined as the ...
Pinheiro R O RO Leprosy Laboratory, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation, Fiocruz, - - 2013
Previous studies have demonstrated that cells from both multi-drug-resistant tuberculosis (MDR-TB) and non-tuberculous mycobacteria (NTM) patients respond poorly to mycobacterial antigens in vitro. In the present study, we compared the in vitro response of cells isolated from sensitive TB (NR-TB)-, MDR-TB- and NTM-infected patients. Analysis of T cell phenotype ex ...
Kox M M Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. - - 2013
Vitamin D has been shown to modulate innate immune responses in vitro and ex vivo; however, human in-vivo data are lacking. At high latitudes, seasonal vitamin D deficiency is common due to alternating ultraviolet (UV)-B radiation exposure. In the present study, we investigated whether levels of 25 hydroxyvitamin D(3) [25(OH)D(3) ...
Cholette Jill M JM Department of Pediatrics, University of Rochester, Rochester, NY, USA. - - 2013
To evaluate whether transfusion of cell saver salvaged, stored at the bedside for up to 24 hrs, would decrease the number of postoperative allogeneic RBC transfusions and donor exposures, and possibly improve clinical outcomes. Prospective, randomized, controlled, clinical trial. Pediatric cardiac intensive care unit. Infants weighing less than 20 kg ...
Nguyen T G TG Perinatal Research, Kolling Institute of Medical Research, North Shore Hospital, Sydney, Australia. - - 2013
Maternal immune responses during pregnancy are critical in programming the future health of a newborn. The maternal immune system is required to accommodate fetal immune tolerance as well as to provide a protective defence against infections for the immunocompromised mother and her baby during gestation and lactation. Natural immunity and ...
Rose K K Pharmazentrum Frankfurt/ZAFES, Frankfurt am Main, - - 2013
Vitamin D (VD) has been implicated in type 1 diabetes (T1D) by genetic and epidemiological studies. Individuals living in regions with low sunlight exposure have an increased T1D risk and VD supplementation reduced the risk in human individuals and mouse models. One possibility of how VD influences the pathogenesis of ...
Bright P P Immunology Department, Barts Health NHS Trust, London, - - 2013
Common variable immunodeficiency (CVID) is the most common severe primary immunodeficiency, but the pathology of this condition is poorly understood. CVID involves a defect in the production of immunoglobulin from B cells, with a subsequent predisposition to infections. Approximately 10-20% of cases are inherited, but even in families with a ...
Christensen A D AD Experimental Immunology Group, Department of Immunopharmacology, Novo Nordisk A/S, Måløv, - - 2013
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4)-immunoglobulin (Ig) has immunosuppressive properties both in vivo and in vitro, but much is still unknown about the mechanisms by which CTLA-4-Ig exerts its immunosuppressive activities in vivo. The aim of this study was to investigate the effect of CTLA-4-Ig in a mouse model of contact ...
Nataraj N B NB Department of Biotechnology, University of Mysore, Karnataka, - - 2013
Rheumatoid arthritis (RA) is a polyarticular inflammatory, angiogenic disease. Synovial angiogenesis contributes to inflammation in RA. In this study we have developed an arthritic model in rats using a novel angiogenic protein (NAP), isolated from human synovial fluid of RA patients. We produced anti-NAP monoclonal antibodies (mAbs) and investigated the ...
Murng S H K SH Immunology Department, Northern General Hospital, Sheffield, - - 2013
Serum free light chain (sFLC) measurement has gained widespread acceptance and is incorporated into various diagnostic and response criteria. Non-linearity and antigen excess are the main causes of 'variability' in the measurement of sFLC using immunoassay, but the impact of these on measurement has been unclear. We performed a retrospective ...
Bembea Melania M MM Department of Anesthesiology and Critical Care, Johns Hopkins University, Baltimore, MD, USA. - - 2013
The objective of this study was to determine current practices of anticoagulation in patients on extracorporeal membrane oxygenation. Internet-based cross-sectional survey distributed between November 2010 and May 2011. Extracorporeal Life Support Organization-registered extracorporeal membrane oxygenation centers internationally. : Extracorporeal membrane oxy genation medical directors and coordinators. None. There were 121 ...
McCallum J Bruce JB Department of Anesthesiology, The Medical College of Wisconsin, Milwaukee, WI 53226, - - 2013
Previously observed increased sensitivity to noxious stimulation in the Dahl salt-sensitive rat strain (SS/JrHsdMcwi, abbreviated as SS) compared to Brown Norway rats (BN/NhsdMcwi abbreviated as BN) is mediated by genes on a single chromosome. The current study used behavioral and electrocortical data to determine if differences also exist between SS ...
William William N WN Jr Departments of Thoracic/Head and Neck Medical Oncology, Carolinas HealthCare System, Charlotte, North Carolina, - - 2013
This study's objectives were to determine whether tumor response measured by computed tomography (CT) and evaluated using Response Evaluation Criteria in Solid Tumors (RECIST) correlated with overall survival (OS) in patients with non-small-cell lung cancer (NSCLC) after neoadjuvant chemotherapy and surgical resection. We measured primary tumor size on CT before ...
Blume Lawrence C LC Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, NC 27157, - - 2013
Although biochemical and physiological evidence suggests a strong interaction between striatal CB1 cannabinoid (CB1 R) and D2 dopamine (D2 R) receptors, the mechanisms are poorly understood. We targeted medium spiny neurons of the indirect pathway using shRNA to knockdown either CB1 R or D2 R. Chronic reduction in either receptor ...
Chen Wenyong W Department of Chemistry, University of California, Berkeley, California 94720, - - 2013
We report a highly diastereo- and enantioselective allylation of azlactones catalyzed by the combination of a metallacyclic iridium complex and an optically inactive phosphate anion. The process demonstrates an approach for conducting diastereoselective reactions with prochiral nucleophiles in the presence of metallacyclic allyliridium complexes. The reaction provides access to an ...
Tubbs Jason D JD Department of Chemistry, University of Rochester, Rochester, NY 14627, - - 2013
The sequence dependence of RNA energetics is important for predicting RNA structure. Hairpins with C(n) loops are consistently less stable than hairpins with other loops, which suggests the structure of C(n) regions could be unusual in the "unfolded" state. For example, previous nuclear magnetic resonance (NMR) evidence suggested that polycytidylic ...
Thiagarajan Giridhar G Department of Bioengineering, University of Utah , Salt Lake City, Utah 84112, - - 2013
Development of carrier systems to improve oral bioavailability and target drugs to specific sites continues to be an unmet need. The goal of this study was to evaluate the potential of anionic generation (G) 6.5 poly(amido amine) (PAMAM) dendrimers in oral drug delivery by assessing their in vivo oral translocation. ...
Hou Guangjin G Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, - - 2013
The proton chemical shift (CS) tensor is a sensitive probe of structure and hydrogen bonding. Highly accurate quantum-chemical protocols exist for computation of (1)H magnetic shieldings in the various contexts, making proton chemical shifts potentially a powerful predictor of structural and electronic properties. However, (1)H CS tensors are not yet ...
Kumar T Santhosh TS Molecular Recognition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, Maryland 20892, - - 2013
Activation of a cardiac myocyte P2X4 receptor protects against heart failure. 5'-Phosphonate and 5'-phosphate analogues of AMP containing a (N)-methanocarba (bicyclo[3.1.0]hexane) system could protect from heart failure by potentially activating this cardioprotective channel. Phosphoesters and phosphonodiesters were synthesized and administered in vivo via a miniosmotic pump in a mouse ischemic ...
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