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Results 401 - 450 of 2749
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Venkata Subbarao R - - 2013
Employing the concept of effective Hamiltonians, an analytical theory is introduced to describe transitions in a multi-level system in nuclear magnetic resonance (NMR) spectroscopy. Specifically, the discussion is centered towards the treatment of selective and non-selective excitations in static quadrupolar spin (I > 1/2) systems. To this end, effective radiofrequency ...
Ahn So Yoon - - 2013
BACKGROUND AND PURPOSE: Severe intraventricular hemorrhage (IVH) in premature infants and the ensuing posthemorrhagic hydrocephalus cause significant mortality and neurological disabilities, and there are currently no effective therapies. This study determined whether intraventricular transplantation of human umbilical cord blood-derived mesenchymal stem cells prevents posthemorrhagic hydrocephalus development and attenuates brain damage ...
Pathem Bala Krishna - - 2013
Dihydroazulenes are photochromic molecules that reversibly switch between two distinct geometric and conductivity states. Molecular design, surface attachment, and precise control over the assembly of such molecular machines are critical in order to understand molecular function and motion at the nanoscale. Here, we use surface-enhanced Raman spectroscopy on special atomically ...
Martin Emily T - - 2013
Background. The identification of multiple viruses during respiratory illness is increasing with advances in rapid molecular testing, however the epidemiology of respiratory viral coinfections is not well known.Methods. 225 childcare attendees were prospectively followed for up to 2 years. Nasal swabs were collected at respiratory illness onset and every 7-10 days until ...
Yost Kathleen J - - 2013
BACKGROUND: Patient-reported signs and symptoms are often the first indication of clinically relevant lymphedema. OBJECTIVE: Develop and assess the diagnostic accuracy of a screening questionnaire to detect lower extremity lymphedema (LEL) among normal weight and obese women. DESIGN: Cross-sectional survey study. METHODS: We reviewed existing questionnaires assessing upper extremity lymphedema ...
Herrera Fernanda G - - 2013
ABSTRACT: BACKGROUND: Whole pelvis intensity modulated radiotherapy (IMRT) is increasingly being used to treat cervical cancer aiming to reduce side effects. Encouraged by this, some groups have proposed the use of simultaneous integrated boost (SIB) to target the tumor, either to get a higher tumoricidal effect or to replace brachytherapy. ...
Kumar N Pradeep - - 2013
Dengue fever is re-emerging as a major scourge in south-east Asian countries affecting about 50-100 million people and causing about 25,000 mortality annually. India as a whole is under the risk of infection of this disease. We genetically characterized viruses causing Dengue infections in Kerala, one of the worst affected ...
Martos-Maldonado Manuel Cristo - - 2013
An easy-to-prepare series of electroactive PAMAM-based dendrimers of generations G0 to G2 having mannopyranosylferrocenyl moieties in the periphery to detect carbohydrate-protein interactions is reported. The synthesis involved the functionalization of the PAMAM surface with azidomethylferrocenyl groups and subsequent coupling of mannoside units by Cu(I)-catalyzed Huisgen reaction. The binding affinity of ...
Poulsen Otto Melchior - - 2013
Aims: To describe the distribution of subjective health complaints (SHCs) in a Danish working population and the associations between SHC and register based sickness absence. Methods: The study entailed 2876 men and 3574 women aged 18-59 years that constituted the 2005 panel in the Danish Work Environment Cohort Study (DWECS). ...
Wang Shu - - 2013
ABSTRACT The disinfection by-products, 3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone (MX) and microcystins-LR (MC-LR), common contaminants in drinking water, often occur together in water sources in areas with high gastrointestinal tract cancer risks. While often studied alone, combination effects of these compounds are unknown. Here, we examine combined genotoxic responses to mixtures of MX and ...
Pitance L - - 2013
Abstract Background: Open-vent jet nebulizers are frequently used to promote drug deposition in the lung, but their clinical efficacy and indications are not clear. Our study compared lung deposition of amikacin using two different configurations of a jet nebulizer (Sidestream(®)): one vented (N(1)) and one unvented with a corrugated piece ...
Kaluza David - - 2013
OBJECTIVE: Histone deacetylases (HDACs) modulate gene expression by deacetylation of histone and nonhistone proteins. Several HDACs control angiogenesis, but the role of HDAC9 is unclear. METHODS AND RESULTS: Here, we analyzed the function of HDAC9 in angiogenesis and its involvement in regulating microRNAs. In vitro, silencing of HDAC9 reduces endothelial ...
Kambhampati Suman - - 2013
2-Methoxyestradiol (2-ME2) is an endogenous metabolite of estradiol. Previous studies demonstrated that 2-ME2 is a potent antiproliferative, pro-apoptotic, antiangiogenic drug and exogenous 2-ME2 is effective against different types of tumors. Unfortunately, only low systemic concentrations of 2-ME2 can be achieved following oral administration, even after very high doses are administered ...
van der Zee Marten - - 2013
Endometrioid endometrial cancer arises through a gradual series of histological changes, each accompanied by specific alterations in gene expression and activity. Activation of the Wnt/β-catenin pathway and loss of PTEN activity are frequently observed in endometrial cancers. However, the specific roles played by alterations in these pathways in the initiation ...
Gheonea Dan Ionut - - 2013
ABSTRACT: BACKGROUND: Second-generation intravenous blood-pool ultrasound contrast agents are increasingly used in endoscopic ultrasound (EUS) for characterization of microvascularization, differential diagnosis of benign and malignant focal lesions, as well as improved staging and guidance of therapeutic procedures. METHODS: The aim of our study was to prospectively compare the vascularisation patterns ...
Rosefort Audrey - - 2013
Abstract Chorioangioma is the most common benign vascular placental tumor. It is often small and has no clinical significance. Large chorioangiomata are rarer and can lead to fetal or maternal complications. Chorangiomatosis or chorioangomatosis is even rarer and is defined as a focal or multifocal proliferation of placental capillaries permeating ...
Albrecht Karoline - - 2013
OBJECTIVE: The purpose of this study was to explore the impact of self-efficacy for coping with cancer (SECC) on physical fatigue and depressive symptoms in melanoma patients, in comparison with objective factors, such as treatment with interferon-alpha (IFN-α) and medical and sociodemographic variables. Current literature shows that psychological distress in ...
Tamaki Kentaro - - 2013
Breast cancer mortality is gradually increasing in Okinawa. The 1st Okinawa Breast Oncology Meeting was held on 6 July 2012 and discussions on how to curb the rising trend were focused on breast cancer screening, adjuvant treatment, socioeconomic and geographic issues, and the problem of complementary and alternative medicine. The ...
Vines Timothy H - - 2013
The data underlying scientific papers should be accessible to researchers both now and in the future, but how best can we ensure that these data are available? Here we examine the effectiveness of four approaches to data archiving: no stated archiving policy, recommending (but not requiring) archiving, and two versions ...
Kaddour Hadhemi - - 2013
Oxidative stress, induced by various neurodegenerative diseases, initiates a cascade of events leading to apoptosis, and thus plays a critical role in neuronal injury. In this study, we have investigated the potential neuroprotective effect of the octadecaneuropeptide (ODN) on 6-hydroxydopamine (6-OHDA)-induced oxidative stress and apoptosis in cerebellar granule neurons (CGN). ...
Porat Shay - - 2013
Objectives: To determine the pathologic basis and clinical associations of excessively thick placentas observed at second-trimester ultrasound examinations. Methods: Maximum sonographic placental thickness was correlated with clinical outcomes, maximum placental thickness after delivery and placental pathologic findings in a retrospective cohort of 19 singleton high-risk pregnancies noted to have a ...
Xia Ai-Bao - - 2013
The organocatalytic Michael reaction of ketones with gamma-monohalonitrodienes catalyzed by chiral prolinethiol ether under solvent-free conditions was developed. The described method represents a novel approach for accessing highly functionalized monohaloalkenes with alpha, beta-stereocenters of up to >99% ee.
Dewitt Douglas - - 2013
Approximately 75% of traumatic brain injuries (TBI) are classified mild (mTBI). Despite the high frequency of mTBI, it is the least well studied. The prevalence of mTBI among service personnel returning from Operations Iraqi Freedom (OIF) and Enduring Freedom (OEF) and the recent reports of an association between repeated mTBI ...
Tripuraneni Manasa - - 2013
OBJECTIVES/HYPOTHESIS: To study the correlation between obstructive sleep apnea (OSA), obesity, behavior, and quality of life. STUDY DESIGN: Case-control study of pediatric OSA documented by polysomnography at a tertiary-care hospital. METHODS: Caregivers signed a consent document and completed the Behavior Assessment System for Children (BASC-2) and the 18-item OSA Quality-of-Life ...
Dequatre-Ponchelle Nelly - - 2013
BACKGROUND AND PURPOSE: The high prevalence of atrial fibrillation in aging populations leads to an increasing incidence of vitamin K antagonists-associated intracerebral hemorrhages (VKAs-ICH). It remains unclear whether VKAs are causes or risk factors for ICH. We aimed at identifying the specificities of VKAs-ICH. METHODS: We compared baseline characteristics of ...
Jurczyk Matthew - - 2013
Epithelioid hemangioendothelioma (EHE) of the liver is an extremely rare tumor that masquerades as an epithelial neoplasm and poses significant diagnostic pitfalls for the cytopathologist. This report describes a 64-year-old woman whom on computerized tomography was found to have multiple peripherally calcified hypodense lesions throughout the liver and an ipsilateral ...
Chatzidionysiou K - - 2013
Objective: The purpose of this study was to characterize and compare responses in patients who had failed one tumour necrosis factor (TNF) inhibitor when switching to another TNF inhibitor or rituximab (RTX). Methods: The Stockholm TNF follow-up registry (STURE) was used. Treatment results at 6 months were analysed by (i) ...
Gregersen Jw - - 2013
Objectives: The combination of anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) and severe infection presents a challenge because current therapies with high-dose glucocorticoids and cyclophosphamide (CYC) are immunosuppressive and increase the risk of infection. Thus, coincident infection delays and complicates the introduction of treatment. Rituximab (RTX) is an alternative to CYC ...
de Jager Saskia C A - - 2013
OBJECTIVE: Despite common disbelief that neutrophils are involved in atherosclerosis, evidence is accumulating for a causal role of neutrophils in atherosclerosis. CCL3 is an inflammatory chemokine and its expression is significantly increased during atherosclerotic lesion formation in mice. It has recently been shown that under conditions of inflammation neutrophils can ...
Oborský Pavel - - 2013
Iduronic acid (IdoA), unlike most other monosaccharides, can adopt different ring conformations depending on the context of the molecular structure. Accurate modeling of this building block is essential for understanding the role of glycosaminoglycans and other glycoconjugates. Here, we use metadynamics to predict equilibria of 1C4, 4C1 and 2SO conformations ...
Yang Zhi-Yong - - 2013
The self-assembly of truxenone on highly oriented pyrolytical graphite (HOPG) was investigated with scanning tunneling microscopy (STM) and density functional theory (DFT) calculations. Truxenone assembled into a dense hexagonal adlayer with large and near-perfect domains on the graphite surface. Two types of topography image of truxenone were observed in experiments. ...
Gupta Himani - - 2013
ABSTRACT BACKGROUND: Although chronic obstructive pulmonary disease (COPD) affects large sections of the population, its effects on postoperative outcomes have not been rigorously studied. Our objectives were to describe the prevalence of COPD in patients undergoing surgery and to analyze the associations between COPD and postoperative morbidity, mortality, and length ...
Jain Felipe A - - 2013
BACKGROUND: There are many prognostic factors for treatment outcome in major depressive disorder (MDD). The predictive power of any single factor, however, is limited. We aimed to develop profiles of antidepressant response and remission based upon hierarchical combinations of baseline clinical and demographic factors. METHODS: Using data from Level 1 ...
Engel Samuel S - - 2013
ABSTRACT: OBJECTIVE: To compare the incidence of cardiovascular events and mortality in patients with type 2 diabetes mellitus treated with sitagliptin or non-sitagliptin comparators. METHODS: A post hoc assessment of cardiovascular safety in 14,611 patients was performed by pooling data from 25 double-blind studies, which randomised patients at baseline to ...
Iglesias Emilia - - 2013
The nitrosation of acetylacetone (AcAc) has been revised in an aqueous acid medium of perchloric acid and buffers of mono-, di-, or tri-chloroacetic acid. The results show that in the presence of buffers, under conditions of [nit] ≪ [AcAc] (nit = sodium nitrite) the reaction cannot be studied by UV-Vis ...
Kang Jianli - - 2013
Electrochemical energy storage: The performance of MnO(2) as a pseudo-capacitive material was enhanced by doping electrodeposited MnO(2) with physically deposited gold atoms. The resulting MnO(2) electrodes showed an enhanced electronic conductivity and a remarkable stability under voltammetric cycling.
Plaza-Zamora J - - 2013
Maternal milk is the first source of exogenous polyamines for the newborn. Polyamines modulate gut maturation in neonates, but no studies are available on polyamine concentration in human milk of preterm babies, even though they could be important for their immature gut. The present study aimed to determine polyamine concentration ...
Seror Raphaèle - - 2013
Objective. To determine the pattern of demyelinating disorders (DDs) occurring during anti-TNF-α therapy.Methods. Between June 2005 and April 2008, 1800 French rheumatologists and internists were contacted to report cases of DDs occurring in patients treated with anti-TNF-α.Results. After a median of 10.2 (1.5-39.9) months of treatment, 33 patients developed DDs: ...
Møller M H - - 2013
BACKGROUND: Mortality and morbidity are considerable after treatment for perforated peptic ulcer (PPU). Since 2003, a Danish nationwide quality-of-care (QOC) improvement initiative has focused on reducing preoperative delay, and improving perioperative monitoring and care for patients with PPU. The present study reports the results of this initiative. METHODS: This was ...
Tan Sih Min - - 2013
PURPOSE: Glutathione peroxidase-1 (GPx1) is highly expressed during normal retinal maturation; however its role in retinopathy of prematurity (ROP) is not fully understood. We postulated that GPx1 plays an important role in protecting the premature retina from oxidative injury in a mouse model of ROP. METHODS: ROP was induced in ...
Del Pozo-Rodríguez Ana - - 2013
Abstract This review highlights the application of lipid nanoparticles (Solid Lipid Nanoparticles, Nanostructured Lipid Carriers, or Lipid Drug Conjugates) as effective drug/gene delivery systems for retinal diseases. Most drug products for ocular disease treatment are marketed as eye drop formulations but, due to ocular barriers, the drug concentration in the ...
Hammond Karl D - - 2013
We present pair-wise, charge-neutral model potentials for an iron-titanium-yttrium-oxygen system. These simple models are designed to provide a tractable method of simulating nanostructured ferritic alloys (NFAs) using off-lattice Monte Carlo and molecular dynamics techniques without deviating significantly from the formalism employed in existing Monte Carlo simulations. The model is fitted ...
Franke K - - 2013
Theory predicts that inbreeding depression should be more pronounced under environmental stress due to an increase in the expression of recessive deleterious alleles. If so, inbred populations may be especially vulnerable to environmental change. Against this background, we here investigate effects of inbreeding, temperature stress and its interactions with inbreeding ...
Tian Geng - - 2013
Abstract Background: Previous studies have characterized the size increase of combination submicrometer particles composed of a drug and hygroscopic excipient when exposed to typical airway thermodynamic conditions. The objective of this study was to determine the deposition and size increase characteristics of excipient enhanced growth (EEG) aerosols throughout the tracheobronchial ...
Tang Sung-Chun - - 2013
OBJECTIVE: Little is known about the involvement of the soluble form of receptor for advanced glycation end products (sRAGE) in acute ischemic stroke (IS). Here, we aim to identify the role of plasma sRAGE and high mobility group box 1 (HMGB1) in imaging-confirmed IS patients, as well as mice subjected ...
Pang Yongzhen - - 2013
Tea (Camellia sinensis) is rich in specialized metabolites, especially polyphenolic proanthocyanidins (PAs) and their precursors. To better understand the PA pathway in tea, we generated a cDNA library from leaf tissue of the blister blight-resistant tea cultivar TRI2043, and functionally characterized key enzymes responsible for the biosynthesis of PA precursors. ...
Badiyan Shahed N - - 2013
ABSTRACT: INTRODUCTION: Ongoing prospective trials exploring stereotactic body radiation therapy (SBRT) for early stage non-small cell lung cancer (NSCLC) often exclude minimally invasive adenocarcinoma or adenocarcnioma in situ, formerly bronchioloalveolar carcinoma (BAC), due to concerns for accurate target delineation on CT. We performed a patterns of failure analysis to compare ...
Iwaki Toshio - - 2013
Untargeted metabolome analyses play a critical role in understanding possible metabolic fluctuations of crops under varying environmental conditions. In this study, we report metabolic profiles of transgenic potato tubers expressing the Arabidopsis DREB1A transcription factor gene, which induces expression of genes involved in environmental stress tolerance. A combination of targeted ...
Thomas Adam D - - 2013
Recent evidence has challenged the default assumption that all DNA reactive alkylating agents exhibit a linear dose-response. Emerging evidence suggests that the model alkylating agents; methyl- and ethyl-methanesulfonate (MMS and EMS) and methyl- and ethyl-nitrosurea (MNU and ENU) observe a non-linear dose-response with a no observed genotoxic effect level (NOGEL). ...
Zhu Yingdong - - 2013
Sphingolipids are known to have diverse properties and physiological functions. These distinctive lipids have been identified in wheat bran, a food well known for its chemopreventative activities. However, the complete profile of sphingolipids in wheat bran and their contributions to the cancer preventive effect of wheat bran have not been ...
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