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Results 401 - 450 of 2749
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Pujari Sidharam P - - 2013
Organic monolayers derived from ω-fluoro-1-alkynes of varying carbon chain lengths (C(10)-C(18)) were prepared on Si(111) surfaces, resulting in changes of the physical and electronic properties of the surface. Analysis of the monolayers using XPS, Infrared Reflection Absorption Spectroscopy, ellipsometry and static water contact angle measurements provided information regarding the monolayer ...
Proper Karin I - - 2013
OBJECTIVE: This study aims to evaluate the effectiveness of a draft occupational health guideline, aimed at preventing weight gain, on employees' body weight-related outcomes, cardiovascular disease (CVD) risk factors, and quality of life. METHODS: In a cluster randomized controlled trial including 16 occupational physicians (OP) and 523 employees, guideline-based care ...
Pujanauski Lindsey M LM Integrated Department of Immunology, University of Colorado School of Medicine, Denver, CO 80206, - - 2013
A series of potent, broadly neutralizing HIV antibodies have been isolated from B cells of HIV-infected individuals. VRC01 represents a subset of these antibodies that mediate neutralization with a restricted set of IGHV genes. The memory B cells expressing these antibodies were isolated years after infection; thus, the B-cell subpopulation ...
Valentim A M - - 2013
The ketamine/midazolam association of a dissociative with a sedative agent is used for the induction and maintenance of anaesthesia in laboratory animals. Anaesthesia may interfere with research results through side-effects on the nervous system, such as memory impairment. It is known that ketamine and midazolam affect cognition; however, their effects ...
Luoma Ilona - - 2013
Background: Postnatal psychological symptoms have been studied less often in fathers than in mothers. However, recent research shows that fathers' psychopathology may have long-term effects on their children's emotional and behavioural development independently of maternal psychopathology. More research is needed on factors associated with paternal symptoms at the early stage ...
Jithesh P V PV Liverpool Cancer Research UK Centre, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, Block C, Waterhouse Buildings, Brownlow Street, University of Liverpool, Liverpool L69 3GL, UK. - - 2013
There is relatively little methylation array data available specifically for oral squamous cell carcinoma (OSCC). This study aims to compare the DNA methylome across a large cohort of tumour/normal pairs. DNA was extracted from 44 OSCCs and paired normal mucosa. DNA methylation analysis employed the Illumina GoldenGate high-throughput array comprising ...
Crankshaw Denis J - - 2013
Ligands for extracellular calcium-sensing (CaS) receptors inhibit oxytocin-induced contractions of the rat's uterus. In this study, we investigated whether the CaS receptor ligands calindol, cinacalcet, and calhex 231 have similar effects on pregnant human myometrium. We compared their effects to those of the calcium-channel blocker nifedipine. In conventional concentration-effect experiments, ...
Havens J A - - 2013
Sexual signals in cactophilic Drosophila mojavensis include cuticular hydrocarbons (CHCs), contact pheromones that mediate female discrimination of males during courtship. CHCs, along with male courtship songs, cause premating isolation between diverged populations, and are influenced by genotype × environment interactions caused by different host cacti. CHC profiles of mated and unmated adult ...
Scemama Anthony - - 2013
Various strategies to implement efficiently quantum Monte Carlo (QMC) simulations for large chemical systems are presented. These include: (i) the introduction of an efficient algorithm to calculate the computationally expensive Slater matrices. This novel scheme is based on the use of the highly localized character of atomic Gaussian basis functions ...
Boerner Kathrin K Jewish Home Lifecare, Research Institute on Aging, New York, NY 10025, USA. - - 2013
The effectiveness of advance care planning (ACP) may depend on family members' understanding of patient preferences. However, we know of no studies that explore the association between family relationship dynamics and ACP. ACP includes a living will, durable power of attorney for health care (DPAHC) appointment, and discussions. We evaluated ...
Tan Sih Min - - 2013
PURPOSE: Glutathione peroxidase-1 (GPx1) is highly expressed during normal retinal maturation; however its role in retinopathy of prematurity (ROP) is not fully understood. We postulated that GPx1 plays an important role in protecting the premature retina from oxidative injury in a mouse model of ROP. METHODS: ROP was induced in ...
Del Pozo-Rodríguez Ana - - 2013
Abstract This review highlights the application of lipid nanoparticles (Solid Lipid Nanoparticles, Nanostructured Lipid Carriers, or Lipid Drug Conjugates) as effective drug/gene delivery systems for retinal diseases. Most drug products for ocular disease treatment are marketed as eye drop formulations but, due to ocular barriers, the drug concentration in the ...
Hammond Karl D - - 2013
We present pair-wise, charge-neutral model potentials for an iron-titanium-yttrium-oxygen system. These simple models are designed to provide a tractable method of simulating nanostructured ferritic alloys (NFAs) using off-lattice Monte Carlo and molecular dynamics techniques without deviating significantly from the formalism employed in existing Monte Carlo simulations. The model is fitted ...
Franke K - - 2013
Theory predicts that inbreeding depression should be more pronounced under environmental stress due to an increase in the expression of recessive deleterious alleles. If so, inbred populations may be especially vulnerable to environmental change. Against this background, we here investigate effects of inbreeding, temperature stress and its interactions with inbreeding ...
Glass Cathy C Department of Nutrition Therapy, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio, - - 2013
Patients with cirrhosis have increased gluconeogenesis and fatty acid oxidation that may contribute to a low respiratory quotient (RQ), and this may be linked to sarcopenia and metabolic decompensation when these patients are hospitalized. Therefore, we conducted a prospective study to measure RQ and its impact on skeletal muscle mass, ...
Bitoun Jacob P JP Department of Oral and Craniofacial Biology, School of Dentistry, Louisiana State University Health Sciences Center, New Orleans, LA, - - 2013
Streptococcus mutans, the primary causative agent of dental caries, contains two paralogues of the LytR-CpsA-Psr family proteins encoded by brpA and psr, respectively. Previous studies have shown that BrpA plays an important role in cell envelope biogenesis/homeostasis and affects stress responses and biofilm formation by Strep. mutans, traits critical to ...
Tian Geng G 1 Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University , Richmond, VA - - 2013
Previous studies have characterized the size increase of combination submicrometer particles composed of a drug and hygroscopic excipient when exposed to typical airway thermodynamic conditions. The objective of this study was to determine the deposition and size increase characteristics of excipient enhanced growth (EEG) aerosols throughout the tracheobronchial (TB) airways ...
Tang Sung-Chun - - 2013
OBJECTIVE: Little is known about the involvement of the soluble form of receptor for advanced glycation end products (sRAGE) in acute ischemic stroke (IS). Here, we aim to identify the role of plasma sRAGE and high mobility group box 1 (HMGB1) in imaging-confirmed IS patients, as well as mice subjected ...
Pang Yongzhen - - 2013
Tea (Camellia sinensis) is rich in specialized metabolites, especially polyphenolic proanthocyanidins (PAs) and their precursors. To better understand the PA pathway in tea, we generated a cDNA library from leaf tissue of the blister blight-resistant tea cultivar TRI2043, and functionally characterized key enzymes responsible for the biosynthesis of PA precursors. ...
Badiyan Shahed N - - 2013
ABSTRACT: INTRODUCTION: Ongoing prospective trials exploring stereotactic body radiation therapy (SBRT) for early stage non-small cell lung cancer (NSCLC) often exclude minimally invasive adenocarcinoma or adenocarcnioma in situ, formerly bronchioloalveolar carcinoma (BAC), due to concerns for accurate target delineation on CT. We performed a patterns of failure analysis to compare ...
Iwaki Toshio - - 2013
Untargeted metabolome analyses play a critical role in understanding possible metabolic fluctuations of crops under varying environmental conditions. In this study, we report metabolic profiles of transgenic potato tubers expressing the Arabidopsis DREB1A transcription factor gene, which induces expression of genes involved in environmental stress tolerance. A combination of targeted ...
Whittaker Steven R SR Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, - - 2013
RAF inhibitors such as vemurafenib and dabrafenib block BRAF-mediated cell proliferation and achieve meaningful clinical benefit in the vast majority of patients with BRAF(V600E)-mutant melanoma. However, some patients do not respond to this regimen, and nearly all progress to therapeutic resistance. We used a pooled RNA interference screen targeting more ...
Thomas Adam D - - 2013
Recent evidence has challenged the default assumption that all DNA reactive alkylating agents exhibit a linear dose-response. Emerging evidence suggests that the model alkylating agents; methyl- and ethyl-methanesulfonate (MMS and EMS) and methyl- and ethyl-nitrosurea (MNU and ENU) observe a non-linear dose-response with a no observed genotoxic effect level (NOGEL). ...
Zhu Yingdong - - 2013
Sphingolipids are known to have diverse properties and physiological functions. These distinctive lipids have been identified in wheat bran, a food well known for its chemopreventative activities. However, the complete profile of sphingolipids in wheat bran and their contributions to the cancer preventive effect of wheat bran have not been ...
Dal Cin Paola - - 2013
The past 20 years have witnessed extraordinary advances in the field of cytogenetics, with the discovery that a multitude of neoplasms is characterized by identifiable chromosomal changes. The ability of Cytogenetics to aid in the identification and precise classification of a variety of neoplasms has not gone unnoticed by Cytology. ...
Ma Yi-Hui - - 2013
KRAS is an attractive pancreatic ductal adenocarcinoma (PDAC) therapeutic target. E3 ligase is thought to be the component of the ubiquitin conjugation system that is directly responsible for substrate recognition. In this study, an engineered E3 ubiquitin ligase (RC-U) was generated to target the KRAS oncoprotein for ubiquitination and degradation. ...
Pacchioni Gianfranco - - 2013
Understanding the interaction of small metal clusters and isolated atoms with oxide surfaces is crucial in order to rationalize the properties of heterogeneous catalysts composed of sub-nanometer metal particles dispersed on an oxide support. The interaction with the oxide surface can significantly alter the original properties of the metal deposit. ...
Liberato Michelle S - - 2013
We report for the first time on the self-assembly of nanostructures composed exclusively of alternating positively charged and hydrophobic amino acids. A novel arginine/phenylalanine octapeptide, RF8, was synthesized. Because the low hydrophobicity of this sequence makes its spontaneous ordering through solution-based methods difficult, a recently proposed solid-vapor approach was used ...
Patel Mitul K - - 2013
Phosphate esters in polyhydroxylated systems are normally blighted by uncontrolled migration under a variety of reaction conditions. Cesium fluoride is demonstrated as a reagent to control migration of primary phosphates during transesterifications. This allows easy exchange of phosphoryl protecting groups enabling enhanced synthetic strategic flexibility and regioselective phosphate installation. Mechanistic ...
Lipkin W Ian - - 2013
The pace of pathogen discovery is rapidly accelerating. This reflects not only factors that enable the appearance and globalization of new microbial infections, but also improvements in methods for ascertaining the cause of a new disease. Innovative molecular diagnostic platforms, investments in pathogen surveillance (in wildlife, domestic animals and humans) ...
Niclauss Lars L Department of Cardiovascular Surgery, University Hospital of Lausanne, Lausanne, Switzerland. - - 2013
Guidelines proposed bioprosthesis implantation for aortic valve disease if the patients were at least 65 years old at the time of surgery, with a trend towards even younger patients in recent years. Considering the adverse effects of lifetime anticoagulation, new biological valves (less prone to degeneration) and new technologies may ...
Núñez Ivanna Novotny - - 2013
Protein-energy malnutrition (PEM) causes a significant impairment of the immune system, the thymus being one of the most affected organs. It has been demonstrated that the administration of probiotic fermented milk (PFM) recovered the intestinal barrier, histological alterations and mucosal and systemic immune functions in a non-severe malnutrition model using ...
Boscolo Elisa E Vascular Biology Program and Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, - - 2013
Infantile hemangioma (IH) is a rapidly growing vascular tumor affecting newborns. It is composed of immature endothelial cells and pericytes that proliferate into a disorganized mass of blood vessels. We isolated pericytes from IH (Hem-pericytes) to test our hypothesis that Hem-pericytes are unable to stabilize blood vessels. We injected pericytes ...
Koseoglu Secil S Department of Chemistry, University of Minnesota, Minneapolis, MN, - - 2013
Platelet granule exocytosis serves a central role in hemostasis and thrombosis. Recently, single-cell amperometry has shown that platelet membrane fusion during granule exocytosis results in the formation of a fusion pore that subsequently expands to enable the extrusion of granule contents. However, the molecular mechanisms that control platelet fusion pore ...
Jadidi-Niaragh Farhad - - 2013
Little is known regarding the immunobiology of regulatory T (Treg) cells in hematopoietic malignancies, particularly in chronic lymphocytic leukemia (CLL). In the present study, we showed that the frequencies of CD8(+) and CD4(+) Treg cells were significantly increased in progressive as compared with indolent CLL patients and normal subjects. Enriched ...
Iskandar Michèle M MM School of Dietetics and Human Nutrition, Macdonald Campus of McGill University, Sainte Anne de Bellevue, QC, Canada H9X - - 2013
Whey proteins (WP) exert anti-inflammatory and antioxidant effects. Hyperbaric pressurisation of whey increases its digestibility and changes the spectrum of peptides released during digestion. We have shown that dietary supplementation with pressurised whey improves nutritional status and systemic inflammation in patients with cystic fibrosis (CF). Both clinical indices are largely ...
Haugarvoll Kristoffer - - 2013
ABSTRACT: BACKGROUND: Correct diagnosis is pivotal to understand and treat neurological disease. Herein, we report the diagnostic work-up utilizing exome sequencing and the characterization of clinical features and brain MRI in two siblings with a complex, adult-onset phenotype; including peripheral neuropathy, epilepsy, relapsing encephalopathy, bilateral thalamic lesions, type 2 diabetes ...
Landry Jerome C JC Emory University and Winship Cancer Institute, Atlanta, Georgia, USA. - - 2013
Recent studies have demonstrated the feasibility of combining oxaliplatin with 5-fluorouracil (5-FU) or capecitibine and radiation therapy. The addition of bevacizumab to chemotherapy improves overall survival for metastatic disease. We initiated a phase 2 trial to evaluate preoperative capecitabine, oxaliplatin, and bevacizumab with radiation therapy followed by surgery and postoperative ...
Fredrickson M J - - 2013
In-plane vs out-of-plane needle-probe alignment for perineural catheter placement remains controversial. Patients presenting for major knee surgery were randomly assigned to out-of-plane (n = 42) or in-plane (n = 39) needle-probe alignment for femoral nerve catheter placement, with both techniques using short-axis nerve imaging. Twenty millilitres of ropivacaine 0.5% was ...
Gao Wei - - 2013
Organized self-assemblies of Janus catalytic motors, induced by hydrophobic surface interactions involving multiple motor/motor and motor/non-motor particles, display controlled coordinated self propulsion. The influence of the self-assembled structures upon the motion behavior is investigated. A dynamic 'on-the-fly' assembly is observed during the continuous movement of the individual components, along with ...
Krishtop T V - - 2013
We consider the transmission of electrons through a two-dimensional ballistic point contact in the low-conductance regime near the pinch-off region. The scattering of electrons by Friedel oscillations of charge density results in a contribution to the conductance proportional to the temperature. The sign of this linear term depends on the ...
Saxena Akshat A Department of Cardiothoracic Surgery, St Vincent's Hospital Melbourne, Fitzroy, VIC, - - 2013
Preoperative atrial fibrillation (PAF) has been associated with poorer early and mid-term outcomes after isolated valvular or coronary artery bypass graft surgery. Few studies, however, have evaluated the impact of PAF on early and mid-term outcomes after concomitant aortic valve replacement and coronary aortic bypass graft (AVR-CABG) surgery. Data obtained ...
Sanchez-Villegas Almudena - - 2013
ABSTRACT: BACKGROUND: Research on the role of diet in the prevention of depression is scarce. Some evidence suggests that depression shares common mechanisms with cardiovascular disease. DISCUSSION: Before considering the role of diet in the prevention of depression, several points need to be considered. First, in general, evidence has been ...
Newman Andrew C AC Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, - - 2013
Angiogenesis requires tightly coordinated crosstalk between endothelial cells (ECs) and stromal cells, such as fibroblasts and smooth muscle cells. The specific molecular mechanisms moderating this process are still poorly understood. Stromal cell-derived factors are essential for EC sprouting and lumen formation. We therefore compared the abilities of 2 primary fibroblast ...
Hearn Bryan A - - 2013
INTRODUCTION: Iq'mik, a form of smokeless tobacco (ST), is traditionally used by Cup'ik and Yup'ik Eskimo people of western Alaska. Iq'mik is sometimes incorrectly considered to be a healthier alternative to smoking because its ingredients are perceived as "natural." Our chemical characterization of iq'mik shows that iq'mik is not a ...
Boumail Afia - - 2013
Novel trilayer antimicrobial diffusion films (ADFs) were developed for food applications. ADFs were composed of two external layers of polycaprolactone and one internal layer of nanocellulose (NCC)-reinforced methylcellulose (MC) matrix. Two antimicrobial mixtures (formulations A and B) were incorporated in MC layer and compared via the evaluation of film properties. ...
Lee Patricia L M PL Department of Biosciences, College of Science, Swansea University, Singleton Park, Swansea SA2 8PP, Wales, UK. - - 2013
Reports of nuisance jellyfish blooms have increased worldwide during the last half-century, but the possible causes remain unclear. A persistent difficulty lies in identifying whether blooms occur owing to local or regional processes. This issue can be resolved, in part, by establishing the geographical scales of connectivity among locations, which ...
Peng Li - - 2013
Poring over polymers: Highly porous polymers with hierarchical macro- and mesoporous structures were synthesized by using the title method and UV radiation. The porosity properties of the polymers can be easily tuned by controlling the CO(2) pressure used, and the polymers have potential applications in catalysis. IL=ionic liquid, PAM=polyacrylamide.
Sripirom Jiyapa - - 2013
Carbon tips for in situ scanning tunneling microscopy studies in an electrochemical environment were prepared by electrochemical etching of carbon fibers and subsequent coating with electrodeposition paint and a silicone elastomer. The tips obtained were stable in acidic electrolyte and allowed high-resolution in situ imaging of the bare Au(111) electrode ...
Goff Louise M LM Nutritional Sciences Division, King's College London, London, - - 2013
A cross-sectional analysis of ethnic differences in dietary intake, insulin sensitivity and beta-cell function, using the intravenous glucose tolerance test (IVGTT), was conducted on 497 healthy adult participants of the 'Reading, Imperial, Surrey, Cambridge, and Kings' (RISCK) study. Insulin sensitivity (Si) was significantly lower in African-Caribbean (AC) and South Asian ...
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