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Results 351 - 400 of 2749
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De Salvo G G Southampton Eye Unit, University Hospital Southampton, Southampton, - - 2013
To describe two cases of retinal angiomatous proliferation (RAP)-like lesion following radiation therapy for primary tumor. Retrospective evaluation of two patients with previous irradiation treatment for a pleomorphic adenoma of the lacrimal gland and a vocal cord carcinoma, respectively. Visual acuity (VA), fluorescein angiography and optical coherence tomography were performed ...
Forrester J V JV Institute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, UK. - - 2013
Inflammation, in the pathogenesis of many diseases previously thought to be strictly genetic, degenerative, metabolic, or endocrinologic in aetiology, has gradually entered the framework of a general mechanism of disease. This is exemplified by conditions such as Parkinson's disease, Alzheimer's disease, atherosclerosis, diabetes, and the more recently described Metabolic Syndrome. ...
Kang N H NH Department of Ophthalmology, Ewha Womans University, Seoul, Republic of - - 2013
To assess the change in subfoveal choroidal thickness (SFCT) in central serous chorioretinopathy (CSC) following spontaneous resolution and low-fluence photodynamic therapy (PDT) using the enhanced depth imaging optical coherence tomography (EDI-OCT). A total of 36 consecutive eyes of 36 patients were included in this retrospective study: 16 eyes with spontaneously ...
Crocco Melisa Candela MC Instituto Nacional de Parasitología Mario Fatala Chaben, ANLIS Malbrán, Av. Paseo Colón 568, Buenos Aires, Argentina. - - 2013
Different laboratories around the world have succeeded in establishing human embryonic stem cell (hESC) lines. However, culture conditions vary considerably among the protocols used and the vast majority of the lines at some stage of their creation have been in contact with an animal derived component. One of the main ...
Rouen Alexandre A AP-HP, Hôpital Armand Trousseau, Paris, France. - - 2013
Balanced chromosomal translocations are found in one out of 500 subjects in the general population. They usually do not carry any phenotypic consequences, except for possible infertility and for the production of unbalanced gametes leading to spontaneous abortions or chromosomal syndromes in the offspring. An association between chromosomal rearrangements and ...
Yamada Akimitsu A Department of Clinical Oncology and Breast Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, - - 2013
ATP-binding cassette (ABC) transporters are membrane proteins that efflux various compounds from cells, including chemotherapeutic agents, and are known to affect multidrug resistance. Recent reports disagree on whether ABCC11 is a risk factor for breast tumorigenesis, but its expression in breast cancer is poorly investigated. We hypothesized that both frequency ...
Balli David D Department of Pediatrics, Division of Pulmonary Biology, The Perinatal Institute, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, - - 2013
Alveolar epithelial cells (AECs) participate in the pathogenesis of pulmonary fibrosis, producing pro-inflammatory mediators and undergoing epithelial-to-mesenchymal transition (EMT). Herein, we demonstrated the critical role of Forkhead Box M1 (Foxm1) transcription factor in radiation-induced pulmonary fibrosis. Foxm1 was induced in AECs following lung irradiation. Transgenic expression of an activated Foxm1 ...
Saberi Hosnijeh Fatemeh F Division Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Jenalaan 18D, PO Box 80178, 3508 TD Utrecht, Netherlands. - - 2013
Overweight and obesity have been suggested as a risk factor for leukemia. Impaired immune function associated with obesity, increased insulin-like growth factor-I activity and stimulating effects of leptin suggest a possible biological link between anthropometric measures and leukemia. However, evidence from epidemiological studies has been inconsistent. We examined the potential ...
Pritchard Justin R JR Department of Biology M.I.T., Cambridge, MA, - - 2013
Molecular signatures are a powerful approach to characterize novel small molecules and derivatized small molecule libraries. While new experimental techniques are being developed in diverse model systems, informatics approaches lag behind these exciting advances. We propose an analysis pipeline for signature based drug annotation. We develop an integrated strategy, utilizing ...
Carter Drew D School of Population Health, The University of Adelaide, Adelaide, Australia 5005. - - 2013
Should there be a female age limit on public funding for assisted reproductive technology (ART)? The question bears significant economic and sociopolitical implications and has been contentious in many countries. We conceptualise the question as one of justice in resource allocation, using three much-debated substantive principles of justice-the capacity to ...
Spinale Francis G FG Cardiovascular Translational Research Center, CBA, University of South Carolina School of Medicine, 6439 Garners Ferry Rd, Columbia, SC, USA. - - 2013
The extracellular matrix (ECM) is a complex entity containing a large portfolio of structural proteins, signaling molecules, and proteases. Changes in the overall integrity and activational state of these ECM constituents can contribute to tissue structure and function, which is certainly true of the myocardium. Changes in the expression patterns ...
Kronish Ian M IM Center for Behavioral Cardiovascular Health, Columbia University Medical Center, New York, NY, USA. - - 2013
Even though medications can greatly reduce the risk of recurrent stroke, medication adherence is suboptimal in stroke survivors. To identify key barriers to medication adherence in a predominantly low-income, minority group of stroke and transient ischemic attack (TIA) survivors. Cross-sectional study. Six hundred stroke or TIA survivors, age ≥ 40 ...
Pang Hao H Department of Orthopaedics, Southwest Hospital, The Third Military Medical University, Chongqing, - - 2013
The aim of this study was to examine whether the addition of endothelial progenitor cells (EPCs) contributes to restoring the architectural and functional properties of newly formed bone for reconstruction of bone defects. Bone marrow-derived EPCs and mesenchymal stem cells (MSCs) were co-seeded onto demineralized bone matrix (DBM) as a ...
Olsson E Gunilla A EG School of Global Studies, Global Sustainability Studies, Human Ecology, University of Gothenburg, Box 700, 405 30, Gothenburg, Sweden. - - 2013
The REDD+ scheme of the United Nations intends to offer developing countries financial incentives to reduce the rates of deforestation and forest degradation for reducing global CO2 emissions. This is combined with building carbon stocks in existing wooded ecosystems and fostering other soil, biodiversity and water conservation objectives. Successful application ...
McCrate Oscar A OA Department of Chemistry, Stanford University, Stanford, California 94305, - - 2013
We have demonstrated that curcumin is an amyloid-specific dye in E. coli. Curcumin binds to curliated whole cells and to isolated curli amyloid fibers. Similar to Congo red, curcumin exhibits a red-shift in absorbance and a significant increase in fluorescence upon binding to isolated curli.
Chalmers David - - 2013
Purpose: Venous thromboembolism (VTE) is a major complication of urologic surgery. Data is limited regarding the benefits of heparin prophylaxis for patients undergoing minimally invasive urologic surgery. The AUA recommends sequential compression devices (SCDs) for urologic laparoscopic and robotically assisted procedures but provides no clear recommendations for the use of ...
Jubri Zakiah - - 2013
ABSTRACT: BACKGROUND: Cigarette smoke contains free radicals and an have adverse effect to the immune system. Supplementation of palm oil vitamin E (palmvitee), is known has antioxidant properties is thought to be beneficial for system immune protection against free radicals activity. The objective of the study was to determine the ...
Prosser Gareth A - - 2013
D-cycloserine (DCS) is an antibiotic currently used in the second-line treatment of tuberculosis. DCS is a structural analogue of D-alanine and targets two enzymes involved in the cytosolic stages of peptidoglycan synthesis, alanine racemase (Alr) and D-alanine:D-alanine ligase (Ddl). The mechanisms of inhibition of DCS have been well assessed with ...
Ahmad Aftab - - 2013
Hemichorea, due to contralateral basal ganglia dysfunction, is well described in patients with hyperglycaemia but the underlying mechanism remains poorly understood. We present clinical and radiological data that support ipsilateral vascular compromise to the basal ganglia in such cases. We suggest vascular evaluation in patients with unilateral neurological phenomena secondary ...
Coughlin Steven S - - 2013
The causal and noncausal associations that account for linkages between depressive symptoms and human immunodeficiency virus (HIV)/acquired immune deficiency syndrome are complex and not completely understood. Depression is a common mental health condition that affects approximately 20%-30% of persons receiving HIV medical care. Those suffering from depressive symptoms may be ...
Kim Sung Eun - - 2013
The aim of this study was to improve osteoblast function by delivering two growth factors, PDGF-BB and BMP-2, incorporated onto heparinized titanium (Hep-Ti) substrate. To achieve co-delivery of PDGF-BB and BMP-2, the surface of anodized Ti was immobilized with heparin, and then the two growth factors were coated onto the ...
Yousem Samuel A - - 2013
ABSTRACT BACKGROUND: Pulmonary Langerhans cell histiocytosis is a localized proliferation of Langerhans cells in the lung presenting without systemic manifestations, as bilateral nodular lung disease in adult cigarette smokers. The molecular basis for this proliferation is unknown. METHODS: Concurrent nodules in five patients (22 total) were microdissected from formalin fixed ...
Borówko MaƂgorzata - - 2013
We investigate the structure and adsorption of amphiphilic molecules at planar walls modified by tethered chain molecules using density functional theory. The molecules are modeled as spheres composed of a hydrophilic and hydrophobic part. The pinned chains are treated as tangentially jointed spheres that can interact with fluid molecules via ...
Moubarac Jean-Claude - - 2013
OBJECTIVE: The present study describes the consumption patterns of sweetened food and drink products in a Catholic Middle Eastern Canadian community and examines its associations with physical activity, sedentary behaviours and BMI. DESIGN: A two-stage cross-sectional design was used. In Stage 1 (n 42), 24 h recalls enabled the identification ...
Würslin Christian - - 2013
Hybrid PET/MR combines the exceptional molecular sensitivity of PET with the high resolution and versatility of MR imaging. Simultaneous data acquisition additionally promises the use of MR to enhance the quality of PET images, for example, by respiratory motion correction. This advantage is especially relevant in thoracic and abdominal areas ...
Kokubo Hiroki - - 2013
OBJECTIVE: Acquired heart diseases, such as valve disease, are major causes of human morbidity and mortality. However, the pathological mechanisms underlying these diseases are largely unknown. Our aim is to identify the role of the hairy and enhancer of split-related (Hesr)-2 gene in the adult heart. METHODS AND RESULTS: Echocardiography ...
Koc Mustafa - - 2013
Abstract This study explored Facebook addiction among Turkish college students and its behavioral, demographic, and psychological health predictors. The Facebook Addiction Scale (FAS) was developed and its construct validity was assessed through factor analyses. A total of 447 students reported their personal information and Facebook usage and completed the FAS ...
Mahmood Fareeha - - 2013
Pseudomonas aeruginosa is an important opportunistic bacterial pathogen. Despite its metabolic and virulence versatility, it has not been shown to infect articular joints, which are environments that are rarely infected with bacteria in general. We hypothesized that articular joints possess antimicrobial activity that limits bacterial survival in these environments. We ...
Dufek Matthew B - - 2013
P-glycoprotein (P-gp) and CYP3A/Cyp3a in the intestine can attenuate absorption of orally administered drugs. While some suggest that P-gp enhances intestinal metabolism by CYP3A/Cyp3a during absorption of a dual substrate, others suggest that P-gp reduces the metabolism in the intestine when substrates are at sub-saturating concentrations. Hence, to elucidate the ...
Dunbar Kyle L - - 2013
Ribosomally synthesized posttranslationally modified peptides (RiPPs) are a rapidly growing class of natural products with diverse structures and activities. In recent years, a great deal of progress has been made in elucidating the biosynthesis of various RiPP family members. As with the study of nonribosomal peptide and polyketide biosynthetic enzymes, ...
Nielsen Maj Britt D - - 2013
Introduction: The aims of this paper were to examine how disabled workers assess encounters with return-to-work (RTW) stakeholders during sickness absence due to common mental disorders (CMD) and to investigate gender differences in these assessments. Method: Data on contact with and assessment of encounters with RTW-stakeholders were obtained from a ...
Zhao Chongchao - - 2013
A new series of complexes containing two electron donating groups, {M(CO)(3)}(+) ions, M = Re or Mn, on one polytungstate electron acceptor group have been prepared and characterized. These complexes containing two electron donating groups, {M(CO)(3)}(+) ions, M = Re or Mn, on one polytungstate electron acceptor group have been ...
Conway William Owen - - 2013
Piperazine (PZ) is widely recognised as a promising solvent for post combustion capture (PCC) of carbon dioxide (CO2). In view of the highly conflicting data describing the kinetic reactions of CO2(aq) in piperazine solutions, the present study focuses on the identification of the chemical mechanism, specifically the kinetic pathways for ...
Kapur Narinder - - 2013
Disorders of the brain and its sensory organs have traditionally been associated with deficits in movement, perception, cognition, emotion, and behavior. It is increasingly evident, however, that positive phenomena may also occur in such conditions, with implications for the individual, science, medicine, and for society. This article provides a selective ...
Son Jang Won - - 2013
Objectives. The aim of this study was to evaluate the effects of early intensive insulin therapy on body fat distribution, lean body mass and β-cell function in patients with newly diagnosed type 2 diabetes. Methods. Thirty-eight subjects with newly diagnosed type 2 diabetes participated in a 12-week course of intensive ...
Hsieh Y-C - - 2013
INTRODUCTION: Large granular lymphocytes (LGLs) are medium- to large-sized lymphocytes with azurophilic cytoplasmic granules. Reactive vs. neoplastic LGLs are usually morphologically indistinguishable. METHODS: We investigated 25 consecutive cases of LGL lymphoproliferation using flow cytometric T cell receptor Vβ (FC-Vβ) repertoire and T cell receptor gene rearrangement (TCR-GR) in detecting clonality. ...
Mauri Arabella - - 2013
Tissue engineering is aimed at the fabrication of autologous cardiovascular implants, for example, heart valves or vascular grafts. To date, the mechanical characterization of tissue-engineered vascular grafts (TEVGs) has focused mainly on the material's strength and not on the deformation behavior. A total of 31 samples obtained from 3 mature ...
Barh Debmalya - - 2013
Although attempts have been made to unveil protein-protein and host-pathogen interactions based on molecular insights of important biological events and pathogenesis in various organisms, these efforts have not yet been reported in Corynebacterium pseudotuberculosis (Cp), the causative agent of Caseous Lymphadenitis (CLA). In this study, we used computational approaches to ...
Moreno Juan A - - 2013
OBJECTIVE: High-mobility group box 1 (HMGB1), a DNA-binding cytokine expressed mainly by macrophages, contributes to lesion progression and chronic inflammation within atherosclerotic plaque. It has been suggested that different cytokines could regulate HMGB1 expression in monocytes. We have analyzed the effect of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) ...
Liu Chen-Wei - - 2013
In this paper, a facile strategy to develop graphene-based delivery nanosystems for effective drug loading and sustained drug release was proposed and validated. Specifically, biocompatible naphthalene-terminated PEG (NP) and anticancer drugs (curcumin or doxorubicin (DOX)) were simultaneously integrated onto oxidized graphene (GO) , leading to self-assembled, nano-sized complexes. It was ...
Ferenczy György G - - 2013
The application of the local basis equation (Ferenczy and Adams, J. Chem. Phys. 2009, 130, 134108) in mixed quantum mechanics/molecular mechanics (QM/MM) and quantum mechanics/quantum mechanics (QM/QM) methods is investigated. This equation is suitable to derive local basis nonorthogonal orbitals that minimize the energy of the system and it exhibits ...
Peng Li - - 2013
Poring over polymers: Highly porous polymers with hierarchical macro- and mesoporous structures were synthesized by using the title method and UV radiation. The porosity properties of the polymers can be easily tuned by controlling the CO(2) pressure used, and the polymers have potential applications in catalysis. IL=ionic liquid, PAM=polyacrylamide.
Sripirom Jiyapa - - 2013
Carbon tips for in situ scanning tunneling microscopy studies in an electrochemical environment were prepared by electrochemical etching of carbon fibers and subsequent coating with electrodeposition paint and a silicone elastomer. The tips obtained were stable in acidic electrolyte and allowed high-resolution in situ imaging of the bare Au(111) electrode ...
Hutton Paul - - 2013
Background: More effective psychological treatments for psychosis are required. Case series data and pilot trials suggest metacognitive therapy (MCT) is a promising treatment for anxiety and depression. Other research has found negative metacognitive beliefs and thought-control strategies may be involved in the development and maintenance of hallucinations and delusions. The ...
Setabutr Dhave - - 2013
OBJECTIVES/HYPOTHESES: Nasal bone length is commonly referenced in the rhinoplasty literature. It has been suggested that short nasal bone length may predispose one to a greater risk of middle vault collapse after rhinoplasty. However, there are limited data available on what constitutes the normal dimensions of these pertinent structures of ...
Venkata Subbarao R - - 2013
Employing the concept of effective Hamiltonians, an analytical theory is introduced to describe transitions in a multi-level system in nuclear magnetic resonance (NMR) spectroscopy. Specifically, the discussion is centered towards the treatment of selective and non-selective excitations in static quadrupolar spin (I > 1/2) systems. To this end, effective radiofrequency ...
Ahn So Yoon - - 2013
BACKGROUND AND PURPOSE: Severe intraventricular hemorrhage (IVH) in premature infants and the ensuing posthemorrhagic hydrocephalus cause significant mortality and neurological disabilities, and there are currently no effective therapies. This study determined whether intraventricular transplantation of human umbilical cord blood-derived mesenchymal stem cells prevents posthemorrhagic hydrocephalus development and attenuates brain damage ...
Pathem Bala Krishna - - 2013
Dihydroazulenes are photochromic molecules that reversibly switch between two distinct geometric and conductivity states. Molecular design, surface attachment, and precise control over the assembly of such molecular machines are critical in order to understand molecular function and motion at the nanoscale. Here, we use surface-enhanced Raman spectroscopy on special atomically ...
Martin Emily T - - 2013
Background. The identification of multiple viruses during respiratory illness is increasing with advances in rapid molecular testing, however the epidemiology of respiratory viral coinfections is not well known.Methods. 225 childcare attendees were prospectively followed for up to 2 years. Nasal swabs were collected at respiratory illness onset and every 7-10 days until ...
Yost Kathleen J - - 2013
BACKGROUND: Patient-reported signs and symptoms are often the first indication of clinically relevant lymphedema. OBJECTIVE: Develop and assess the diagnostic accuracy of a screening questionnaire to detect lower extremity lymphedema (LEL) among normal weight and obese women. DESIGN: Cross-sectional survey study. METHODS: We reviewed existing questionnaires assessing upper extremity lymphedema ...
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