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Wordsworth Robin - - 2013
Understanding how Earth has sustained surface liquid water throughout its history remains a key challenge, given that the Sun's luminosity was much lower in the past. Here we show that with an atmospheric composition consistent with the most recent constraints, the early Earth would have been significantly warmed by H(2)-N(2) ...
Santos Daniel W C L - - 2013
Subcutaneous infections caused by melanised fungi have been increasingly reported among transplant patients, and these infections have the potential for blood and visceral dissemination. Some moulds, such as Mycelia sterilia, cannot grow and sporulate on different media, making their identification impossible by conventional methods. The fast and accurate identification of ...
Zhang Huacheng - - 2013
Host-guest complexation between pillararene trimer 1 and biviologen 2 was used to fabricate the dynamic supramolecular self-assembly, which exhibits a reversible multidimensional transformation from 0D to 3D upon concentration changes. As a comparison, assemblies built by the complexation between 1,4-dimethoxypillar[5]arene and 2 only show spherical morphology under similar conditions.
Oakley M Anne - - 2013
Abstract The current study is the first to evaluate the effectiveness of a brief relational-cultural model of therapy in a community-based mental health center for women. The study was distinctive in its use of a hybrid model that employed elements of randomized control and naturalistic design. Results showed that the ...
Pawlowiez Ralph - - 2013
Ciguatera fish poisoning (CFP), a disease caused by consuming fish that have accumulated ciguatoxins (CTXs) in their tissue, is regarded as the most prevalent form of intoxication in French Polynesia. Recently, the Australes, one of the least affected archipelago until the early 1980s, has shown a dramatic increase in its ...
Petzoldt Martin M Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany. - - 2013
Transcardiopulmonary thermodilution (TPTD, SVTD) as well as calibrated (SVPC CAL) and uncalibrated (SVPC UNCAL) arterial pulse contour analysis (PC) are increasingly promoted as less-invasive technologies to measure stroke volume (SV) but their reliability in aortic valve disease was unknown. The objective of this prospective study was to investigate the validity ...
Hulshof Peter J H - - 2013
Tactical planning of resources in hospitals concerns elective patient admission planning and the intermediate term allocation of resource capacities. Its main objectives are to achieve equitable access for patients, to meet production targets/to serve the strategically agreed number of patients, and to use resources efficiently. This paper proposes a method ...
Mozaffarian Rebecca S - - 2013
OBJECTIVE: Eating whole grains (WG) is recommended for health, but multiple conflicting definitions exist for identifying whole grain (WG) products, limiting the ability of consumers and organizations to select such products. We investigated how five recommended WG criteria relate to healthfulness and price of grain products. DESIGN: We categorized grain ...
Alcaro Stefano - - 2013
Oxovitisin is a natural antioxidant present in aged wine and comes from the chemical transformation undergone by anthocyanins and pyranoanthocyanins. Its antioxidant radical scavenging capacity was theoretically explored by DFT/B3LYP methods. The O-H bond dissociation energy (BDE), the ionization potential (IP), the proton affinity (PA) and the metal-oxovitisin binding energy ...
Hsieh Ching-Hua - - 2013
ABSTRACT: BACKGROUND: Previously, we had identified a specific whole blood--derived microRNAs (miRNAs) signature in mice following in vivo injection of lipopolysaccharide (LPS) originated from Gram-negative bacteria. This study was designed to profile the circulating miRNAs expression in mice exposed to lipoteichoic acid (LTA) which is a major component of the ...
Ho Ya-Yeh - - 2013
Bacterial allantoinase (ALLase) and dihydroorotase (DHOase) are members of the cyclic amidohydrolase family. ALLase and DHOase possess similar binuclear metal centers in the active site in which two metals are bridged by a post-translationally carboxylated lysine. In this study, we determined the effects of carboxylated lysine and metal binding on ...
Celekli Abuzer - - 2013
The effective disposal of redundant elephant dung (ED) is important for environmental protection and utilization of resource. The aim of this study was to remove a toxic-azo dye, Reactive Red (RR) 120, using this relatively cheap material as a new adsorbent. The FTIR-ATR spectra of ED powders before and after ...
Xingmao Zhang - - 2013
Local recurrence is a major setback for patients with rectal cancer after surgery. Implantation of exfoliated malignant cells has been considered as a possible mechanism of tumor recurrence. Although still controversial, intra-operative rectal washout has been described as a method to remove exfoliated malignant cells and reduce recurrence rates. The ...
Karl Jenni M JM Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, T1K 3M4, Canada. - - 2013
The Dual Visuomotor Channel theory proposes that skilled reaching is composed of a Reach that directs the hand in relation to the extrinsic properties of an object (e.g., location) and a Grasp that opens and closes the hand in relation to the intrinsic properties of an object (e.g., size). While ...
Evans Nicholas Rhys NR Cardiff School of Engineering, Cardiff University, Queen's Buildings, The Parade, Cardiff, CF24 3AA, UK. - - 2013
To compare the effectiveness of the Aspen, Aspen Vista, Philadelphia, Miami-J and Miami-J Advanced collars at restricting cervical spine movement in the sagittal, coronal and axial planes. Nineteen healthy volunteers (12 female, 7 male) were recruited to the study. Collars were fitted by an approved physiotherapist. Eight ProReflex (Qualisys, Sweden) ...
Fan Xiujuan - - 2013
A novel nanocarrier of magnetic Fe(3)O(4)-graphene nanocomposites (MGNs) was proposed as an effective drug delivery system for cancer treatment. The nanocarrier was synthesized by covalently attaching modified Fe(3)O(4) nanoparticles onto water-soluble graphene sheets via the formation of an amide bond with the aid of 1-ethyl-3-(3-dimethyaminopropyl) carbodiimide. The obtained MGNs exhibited ...
Ma He - - 2013
The near-infrared photoresponse of a single suspended carbon nanocoil (CNC) is investigated. Under the irradiation of a 785 nm laser beam, the photoresponse is generated in the voltage-biased CNC. At a voltage of 50 mV, the ratio of the conductance change to the initial conductance, which is defined as the ...
Lee Youngjun - - 2013
We synthesized a series of Seoul-Fluor-based lipid droplet bioprobes with a linear range of lipophilicity and identified SF44 and SF58 as SF-based LD bioprobes in microalgae for biofuel research as well as in mammalian cells. Unlike Nile Red, SF-based bioprobes can stain algal LDs with excellent efficiency under the non-invasive ...
Adachi Takeshi - - 2013
Heart rate (HR) of mammalian species changes postnatally, i.e., HR of large animals including humans decreases, while HR in small animals such as mice and rats increases. To clarify cellular mechanisms underlying the postnatal HR changes, we performed in vivo HR measurement and electrophysiological analysis on sinoatrial node (SAN) cells ...
Blumberger Jochen - - 2013
We employ a periodic plane-wave implementation of constrained density functional theory to describe electron tunnelling between oxygen vacancy defects in MgO. We find that calculated electron transfer parameters, and therefore electron tunnelling rates, depend sensitively on the fraction of Hartree-Fock exchange (HFX) used to approximate the exchange-correlation functional. In particular, ...
Lo Christine C Academic Unit of Neurology, Sheffield Institute for Translational Neuroscience (SITraN), 385a Glossop Road, Sheffield, - - 2013
Abstract We present a case of concurrent cystic fibrosis (CF) and amyotrophic lateral sclerosis (ALS). To our knowledge this is the first reported coincidence of these two diseases. Although TDP-43 dysfunction has been linked to both pathologies, it does not appear to be pivotal in this individual who does not ...
Kang Jeonghyun - - 2013
BACKGROUND: Anastomotic leakage is a major cause of postoperative morbidity and mortality in the treatment of colorectal cancer. The aim of this study was to investigate the modified double-stapling technique (MDST), as an alternative for conventional double-stapling technique (DST), and whether it could reduce the anastomotic leakage rate in laparoscopic ...
Lee Dong-Wook - - 2013
Coal-fired power plants are facing to two major independent problems, namely, the burden to reduce CO(2) emission to comply with Renewable Portfolio Standard (RPS) and cap-and-trade system, and the need to use low-rank coal due to the instability of high-rank coal supply. To address such unresolved issues, integrated gasification combined ...
Morales-Alamo David - - 2013
The extremely high energy demand elicited by sprint exercise is satisfied by an increase in oxygen consumption combined with a high glycolytic rate, leading to a marked lactate accumulation, increased AMP/ATP ratio, reduced NAD(+)/NADH.H(+) and muscle pH, which are accompanied by marked Thr(172)-AMPKα phosphorylation during the recovery period. To determine ...
Alvarado-Esquivel C - - 2013
The epidemiology of toxocariasis in humans in Mexico has been poorly explored. There is a lack of information about toxocariasis in Tepehuanos, an indigenous ethnic group in Durango State in northern Mexico. Therefore, the presence of anti-Toxocara immunoglobulin (Ig) G antibodies was determined in 126 rural Tepehuanos using an enzyme-linked ...
Degarege A - - 2013
In this cross-sectional study, the associations between helminth infections and ABO blood group, anaemia and undernutrition were investigated in 480 febrile outpatients who visited Dore Bafeno Health Centre, southern Ethiopia, in December 2010. Stool specimens were processed using the Kato-Katz method and examined for intestinal helminth infections. Haemoglobin level was ...
Lin Jie - - 2013
PURPOSE: We describe the preclinical pharmacology and anti-tumor activity of GDC-0068, a novel highly selective ATP-competitive pan-Akt inhibitor currently in clinical trials for the treatment of human cancers. EXPERIMENTAL DESIGN: The effect of GDC-0068 on Akt signaling was characterized using specific biomarkers of the Akt pathway, and response to GDC-0068 ...
Chisolm Margaret S MS Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA. - - 2013
Little is known about the relationship between cigarette smoking and agonist treatment in opioid-dependent pregnant patients. The objective of this study is to examine the extent to which cigarette smoking profiles differentially changed during the course of pregnancy in opioid-dependent patients receiving either double-blind methadone or buprenorphine. Patients were participants ...
Fisher Jeffrey W - - 2013
A biologically-based dose response (BBDR) model for the hypothalamic-pituitary thyroid (HPT) axis in the lactating rat and nursing pup was developed to describe the perturbations caused by iodide deficiency on the HPT axis. Model calibrations, carried out by adjusting key model parameters, were used as a technique to evaluate HPT ...
Hosokawa Hiroyuki H Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts 02114, - - 2013
Previously, we reported an acidification-dependent interaction of the endosomal vacuolar H(+)-ATPase (V-ATPase) with cytohesin-2, a GDP/GTP exchange factor (GEF), suggesting that it functions as a pH-sensing receptor. Here, we have studied the molecular mechanism of signaling between the V-ATPase, cytohesin-2, and Arf GTP-binding proteins. We found that part of the ...
Calì Giuseppe - - 2013
Objective: Evaluate the diagnostic accuracy of 2D gray-scale, Colour Doppler and 3D power Doppler sonographic criteria for morbidly adherent placenta, and identify criteria to help distinguish placenta accreta from percreta. Methods: 187 patients with placenta previa and history of uterine surgery were enrolled in our study and performed a transabdominal ...
Symes Mark D - - 2013
A dyad complex has been constructed as a soluble molecular model of a heterogeneous cobalt-based oxygen-evolving catalyst (Co-OEC). To this end, the Co(4) O(4) core of a cobalt-oxo cubane was covalently appended to Re(I) photosensitisers. The resulting adduct was characterised both in the solid state (by X-ray diffraction) and in ...
Homeyer Nadine - - 2013
In the later stages of drug design projects, accurately predicting relative binding affinities of chemically similar compounds to a biomolecular target is of utmost importance for making decisions based on the ranking of such compounds. So far, the extensive application of binding free energy approaches has been hampered by the ...
Thimm Dominik - - 2013
Adenosine A(2B) receptors, which play a role in inflammation and cancer, are of considerable interest as novel drug targets. To gain deeper insights into ligand binding and receptor activation we exchanged amino acids predicted to be close to the binding pocket. The alanine mutants were stably expressed in CHO cells ...
Son Jang Won - - 2013
Objectives. The aim of this study was to evaluate the effects of early intensive insulin therapy on body fat distribution, lean body mass and β-cell function in patients with newly diagnosed type 2 diabetes. Methods. Thirty-eight subjects with newly diagnosed type 2 diabetes participated in a 12-week course of intensive ...
Hsieh Y-C - - 2013
INTRODUCTION: Large granular lymphocytes (LGLs) are medium- to large-sized lymphocytes with azurophilic cytoplasmic granules. Reactive vs. neoplastic LGLs are usually morphologically indistinguishable. METHODS: We investigated 25 consecutive cases of LGL lymphoproliferation using flow cytometric T cell receptor Vβ (FC-Vβ) repertoire and T cell receptor gene rearrangement (TCR-GR) in detecting clonality. ...
Mauri Arabella - - 2013
Tissue engineering is aimed at the fabrication of autologous cardiovascular implants, for example, heart valves or vascular grafts. To date, the mechanical characterization of tissue-engineered vascular grafts (TEVGs) has focused mainly on the material's strength and not on the deformation behavior. A total of 31 samples obtained from 3 mature ...
Barh Debmalya - - 2013
Although attempts have been made to unveil protein-protein and host-pathogen interactions based on molecular insights of important biological events and pathogenesis in various organisms, these efforts have not yet been reported in Corynebacterium pseudotuberculosis (Cp), the causative agent of Caseous Lymphadenitis (CLA). In this study, we used computational approaches to ...
Moreno Juan A - - 2013
OBJECTIVE: High-mobility group box 1 (HMGB1), a DNA-binding cytokine expressed mainly by macrophages, contributes to lesion progression and chronic inflammation within atherosclerotic plaque. It has been suggested that different cytokines could regulate HMGB1 expression in monocytes. We have analyzed the effect of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) ...
Marquart Tyler J TJ Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, - - 2013
To determine the efficacy of long-term anti-miR-33 therapy on the progression of atherosclerosis in high-fat, high-cholesterol-fed Ldlr(-/-) mice. Ldlr(-/-) mice received saline, or control or anti-miR-33 oligonucleotides once a week for 14 weeks. The treatment was effective, as measured by reduced levels of hepatic miR-33 and increased hepatic expression of ...
Liu Chen-Wei - - 2013
In this paper, a facile strategy to develop graphene-based delivery nanosystems for effective drug loading and sustained drug release was proposed and validated. Specifically, biocompatible naphthalene-terminated PEG (NP) and anticancer drugs (curcumin or doxorubicin (DOX)) were simultaneously integrated onto oxidized graphene (GO) , leading to self-assembled, nano-sized complexes. It was ...
Ferenczy György G - - 2013
The application of the local basis equation (Ferenczy and Adams, J. Chem. Phys. 2009, 130, 134108) in mixed quantum mechanics/molecular mechanics (QM/MM) and quantum mechanics/quantum mechanics (QM/QM) methods is investigated. This equation is suitable to derive local basis nonorthogonal orbitals that minimize the energy of the system and it exhibits ...
Wetzel Alexander - - 2013
[Cp*Ir(Pro)Cl] (Pro = prolinato) was identified among a series of Cp*-iridium half-sandwich complexes as a highly reactive and selective catalyst for the alkylation of amines with alcohols. It is active under mild conditions in either toluene or water without the need for base or other additives, tolerates a wide range ...
Ichihara Yoshinori - - 2013
SH2-containing inositol 5'-phosphatase 2 (SHIP2) is a lipid phosphatase which negatively regulates insulin's metabolic signalling in peripheral tissues; however, the expression of SHIP2 in the hypothalamus and its functional roles are largely unknown. In the present study, immunohistochemical analysis demonstrated that SHIP2 protein exists in neuronal cells expressing neuropeptide Y ...
Kornfelt L F - - 2013
The study examined the effects of harvest time of red and white clover silage on eating and ruminating activity and particle size distribution in feed boli, rumen content and faeces in cows. The clover crops were harvested at two stages of growth and ensiled in bales. Red clover crops had ...
Robat C - - 2013
OBJECTIVES: To determine whether doxorubicin-piroxicam combination is safe and has activity against transitional cell carcinoma in dogs. METHODS: Data was collected retrospectively from 34 dogs from two institutions over a 6-year period. Signalment, clinical presentation, treatment specifics, adverse events, response, progression-free survival and overall survival time were evaluated. RESULTS: Dogs ...
Strejckova Alena - - 2013
Fluorescence experiments were carried out to investigate the interaction of hypericin (Hyp), a natural hydrophobic photosensitizer, with artificial bilayer lipid membranes. The spatial orientation of Hyp monomers incorporated in diphytanoyl phosphatidylcholine (DPhPC) membranes was determined by measuring the dependence of Hyp fluorescence intensity on the angle of incidence of p- ...
Betancourt Eve M - - 2013
Human immunodeficiency virus (HIV)-infected individuals have increased risk of anal intraepithelial neoplasia (AIN) and squamous cell carcinoma (SCC). Cytologic screening is invaluable in the detection of cervical neoplasia, therefore many clinicians have adopted anal cytology as part of anal cancer screening in patients at high-risk for anal neoplasia. The purpose ...
Riquet Florentine - - 2013
Selection processes are believed to be an important evolutionary driver behind the successful establishment of nonindigenous species, for instance through adaptation for invasiveness (e.g. dispersal mechanisms and reproductive allocation). However, evidence supporting this assumption is still scarce. Genome scans have often identified loci with atypical patterns of genetic differentiation (i.e. ...
Steehler Matthew K - - 2013
OBJECTIVES/HYPOTHESIS: To evaluate a previously validated low-cost sinus surgery task trainer as a means of acquiring basic endoscopic sinus surgery skills and as an objective structured assessment of technical skills (OSATS) to determine procedural competency. STUDY DESIGN: Prospective blinded study. METHODS: Medical students (N = 52) with no sinus surgery ...
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