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Rouen Alexandre A AP-HP, Hôpital Armand Trousseau, Paris, France. - - 2013
Balanced chromosomal translocations are found in one out of 500 subjects in the general population. They usually do not carry any phenotypic consequences, except for possible infertility and for the production of unbalanced gametes leading to spontaneous abortions or chromosomal syndromes in the offspring. An association between chromosomal rearrangements and ...
Yamada Akimitsu A Department of Clinical Oncology and Breast Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, - - 2013
ATP-binding cassette (ABC) transporters are membrane proteins that efflux various compounds from cells, including chemotherapeutic agents, and are known to affect multidrug resistance. Recent reports disagree on whether ABCC11 is a risk factor for breast tumorigenesis, but its expression in breast cancer is poorly investigated. We hypothesized that both frequency ...
Balli David D Department of Pediatrics, Division of Pulmonary Biology, The Perinatal Institute, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, - - 2013
Alveolar epithelial cells (AECs) participate in the pathogenesis of pulmonary fibrosis, producing pro-inflammatory mediators and undergoing epithelial-to-mesenchymal transition (EMT). Herein, we demonstrated the critical role of Forkhead Box M1 (Foxm1) transcription factor in radiation-induced pulmonary fibrosis. Foxm1 was induced in AECs following lung irradiation. Transgenic expression of an activated Foxm1 ...
Saberi Hosnijeh Fatemeh F Division Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Jenalaan 18D, PO Box 80178, 3508 TD Utrecht, Netherlands. - - 2013
Overweight and obesity have been suggested as a risk factor for leukemia. Impaired immune function associated with obesity, increased insulin-like growth factor-I activity and stimulating effects of leptin suggest a possible biological link between anthropometric measures and leukemia. However, evidence from epidemiological studies has been inconsistent. We examined the potential ...
Carter Drew D School of Population Health, The University of Adelaide, Adelaide, Australia 5005. - - 2013
Should there be a female age limit on public funding for assisted reproductive technology (ART)? The question bears significant economic and sociopolitical implications and has been contentious in many countries. We conceptualise the question as one of justice in resource allocation, using three much-debated substantive principles of justice-the capacity to ...
Pang Hao H Department of Orthopaedics, Southwest Hospital, The Third Military Medical University, Chongqing, - - 2013
The aim of this study was to examine whether the addition of endothelial progenitor cells (EPCs) contributes to restoring the architectural and functional properties of newly formed bone for reconstruction of bone defects. Bone marrow-derived EPCs and mesenchymal stem cells (MSCs) were co-seeded onto demineralized bone matrix (DBM) as a ...
Olsson E Gunilla A EG School of Global Studies, Global Sustainability Studies, Human Ecology, University of Gothenburg, Box 700, 405 30, Gothenburg, Sweden. - - 2013
The REDD+ scheme of the United Nations intends to offer developing countries financial incentives to reduce the rates of deforestation and forest degradation for reducing global CO2 emissions. This is combined with building carbon stocks in existing wooded ecosystems and fostering other soil, biodiversity and water conservation objectives. Successful application ...
Pritchard Justin R JR Department of Biology M.I.T., Cambridge, MA, - - 2013
Molecular signatures are a powerful approach to characterize novel small molecules and derivatized small molecule libraries. While new experimental techniques are being developed in diverse model systems, informatics approaches lag behind these exciting advances. We propose an analysis pipeline for signature based drug annotation. We develop an integrated strategy, utilizing ...
Kronish Ian M IM Center for Behavioral Cardiovascular Health, Columbia University Medical Center, New York, NY, USA. - - 2013
Even though medications can greatly reduce the risk of recurrent stroke, medication adherence is suboptimal in stroke survivors. To identify key barriers to medication adherence in a predominantly low-income, minority group of stroke and transient ischemic attack (TIA) survivors. Cross-sectional study. Six hundred stroke or TIA survivors, age ≥ 40 ...
McCrate Oscar A OA Department of Chemistry, Stanford University, Stanford, California 94305, - - 2013
We have demonstrated that curcumin is an amyloid-specific dye in E. coli. Curcumin binds to curliated whole cells and to isolated curli amyloid fibers. Similar to Congo red, curcumin exhibits a red-shift in absorbance and a significant increase in fluorescence upon binding to isolated curli.
Spinale Francis G FG Cardiovascular Translational Research Center, CBA, University of South Carolina School of Medicine, 6439 Garners Ferry Rd, Columbia, SC, USA. - - 2013
The extracellular matrix (ECM) is a complex entity containing a large portfolio of structural proteins, signaling molecules, and proteases. Changes in the overall integrity and activational state of these ECM constituents can contribute to tissue structure and function, which is certainly true of the myocardium. Changes in the expression patterns ...
Petzoldt Martin M Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany. - - 2013
Transcardiopulmonary thermodilution (TPTD, SVTD) as well as calibrated (SVPC CAL) and uncalibrated (SVPC UNCAL) arterial pulse contour analysis (PC) are increasingly promoted as less-invasive technologies to measure stroke volume (SV) but their reliability in aortic valve disease was unknown. The objective of this prospective study was to investigate the validity ...
Sedgwick Garry G GG The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, - - 2013
The Anaphase Promoting Complex/Cyclosome (APC/C) in complex with its co-activator Cdc20 is responsible for targeting proteins for ubiquitin-mediated degradation during mitosis. The activity of APC/C-Cdc20 is inhibited during prometaphase by the Spindle Assembly Checkpoint (SAC) yet certain substrates escape this inhibition. Nek2A degradation during prometaphase depends on direct binding of ...
Vu Ly P LP Memorial Sloan-Kettering Cancer Center, New York, NY, - - 2013
Histone-modifying enzymes have recently been shown to play a central role in the regulation of both normal and malignant hematopoiesis. Post-translational modifications of histones and non-histone proteins underlies a regulatory complexity affecting numerous processes including transcriptional regulation, RNA processing and DNA damage response. Insights into the functions of these enzymes ...
Bhagat Shaishav S Department of Orthopaedic Surgery, Norfolk and Norwich University Hospital, Colney lane, Norwich, Norfolk, NR4 7UY, UK. - - 2013
This study analyses the complications of spinal deformity surgery in adults to highlight pre-disposing factors. The clinical records and imaging were reviewed for 48 consecutive patients, 12 males and 36 females, with a mean age of 64 (31-86), who had surgery for spinal deformity. Mean follow-up time was 36 months ...
McNally Lr L James Graham Brown Cancer Center , University of Louisville, Louisville , - - 2013
During the development, progression and dissemination of neoplastic lesions, cancer cells hijack normal pathways and mechanisms, especially those involved in repair and embryologic development. These pathways include those involved in intercellular communication, control of transcription, post-transcriptional regulation of protein production including translation of mRNAs, post-translational protein modifications, e.g., acetylation of ...
Quillérou Emmanuelle E United Nations University Institute for Water, Environment and Health (UNU-INWEH), United Nations University, 175 Longwood Road South, Suite 204, Hamilton, ON, L8P 0A1, Canada. - - 2013
Fishing capacity management policies have been traditionally implemented at national level with national targets for capacity reduction. More recently, capacity management policies have increasingly targeted specific fisheries. French fisheries spatially vary along the French coastline and are associated to specific regions. Capacity management policies, however, ignore the capital mobility associated ...
Moldan Filip F IVL Swedish Environmental Research Institute, Box 53021, 400 14, Gothenburg, Sweden. - - 2013
Decades of acid deposition have caused acidification of lakes in Sweden. Here we use data for 3000 lakes to run the acidification model MAGIC and estimate historical and future acidification. The results indicate that beginning in about 1920 a progressively larger number of lakes in Sweden fell into the category ...
Lawrence Ryan E RE a Department of Psychiatry, Columbia University Medical Center , New York State Psychiatric Institute , New York , NY , - - 2013
Earlier data suggested that religious physicians are less likely to refer to a psychiatrist or psychologist. This follow-up study measures how religious beliefs affect anxiety treatments in primary care. We surveyed US primary care physicians and psychiatrists using a vignette of a patient with anxiety symptoms. Physicians were asked how ...
Cadore E L EL Exercise Research Laboratory, Physical Education School, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, - - 2013
The purpose of the present study was to review the scientific literature that investigated concurrent training adaptations in elderly populations, with the aim of identifying the optimal combination of both training program variables (i.e., strength and endurance) to avoid or minimize the interference effect in the elderly. Scielo, Science Citation ...
Mullin B C BC Department of Psychiatry and Behavioral Sciences, Children's Hospital Colorado, Aurora, CO 15213, - - 2013
Sleep loss produces abnormal increases in reward seeking but the mechanisms underlying this phenomenon are poorly understood. The present study examined the influence of one night of sleep deprivation on neural responses to a monetary reward task in a sample of late adolescents/young adults. Using a within-subjects crossover design, 27 ...
Thomas Vernon George VG Department of Integrative Biology, College of Biological Science, University of Guelph, Guelph, ON, N1G 2W1, Canada, - - 2013
Proposals to end the use of lead hunting ammunition because of the established risks of lead exposure to wildlife and humans are impeded by concerns about the availability, price, and effectiveness of substitutes. The product availability and retail prices of different calibers of lead-free bullets and center-fire rifle ammunition were ...
Chalmers David - - 2013
Purpose: Venous thromboembolism (VTE) is a major complication of urologic surgery. Data is limited regarding the benefits of heparin prophylaxis for patients undergoing minimally invasive urologic surgery. The AUA recommends sequential compression devices (SCDs) for urologic laparoscopic and robotically assisted procedures but provides no clear recommendations for the use of ...
Jubri Zakiah - - 2013
ABSTRACT: BACKGROUND: Cigarette smoke contains free radicals and an have adverse effect to the immune system. Supplementation of palm oil vitamin E (palmvitee), is known has antioxidant properties is thought to be beneficial for system immune protection against free radicals activity. The objective of the study was to determine the ...
Prosser Gareth A - - 2013
D-cycloserine (DCS) is an antibiotic currently used in the second-line treatment of tuberculosis. DCS is a structural analogue of D-alanine and targets two enzymes involved in the cytosolic stages of peptidoglycan synthesis, alanine racemase (Alr) and D-alanine:D-alanine ligase (Ddl). The mechanisms of inhibition of DCS have been well assessed with ...
Ahmad Aftab - - 2013
Hemichorea, due to contralateral basal ganglia dysfunction, is well described in patients with hyperglycaemia but the underlying mechanism remains poorly understood. We present clinical and radiological data that support ipsilateral vascular compromise to the basal ganglia in such cases. We suggest vascular evaluation in patients with unilateral neurological phenomena secondary ...
Coughlin Steven S - - 2013
The causal and noncausal associations that account for linkages between depressive symptoms and human immunodeficiency virus (HIV)/acquired immune deficiency syndrome are complex and not completely understood. Depression is a common mental health condition that affects approximately 20%-30% of persons receiving HIV medical care. Those suffering from depressive symptoms may be ...
Kim Sung Eun - - 2013
The aim of this study was to improve osteoblast function by delivering two growth factors, PDGF-BB and BMP-2, incorporated onto heparinized titanium (Hep-Ti) substrate. To achieve co-delivery of PDGF-BB and BMP-2, the surface of anodized Ti was immobilized with heparin, and then the two growth factors were coated onto the ...
Yousem Samuel A - - 2013
ABSTRACT BACKGROUND: Pulmonary Langerhans cell histiocytosis is a localized proliferation of Langerhans cells in the lung presenting without systemic manifestations, as bilateral nodular lung disease in adult cigarette smokers. The molecular basis for this proliferation is unknown. METHODS: Concurrent nodules in five patients (22 total) were microdissected from formalin fixed ...
Borówko MaƂgorzata - - 2013
We investigate the structure and adsorption of amphiphilic molecules at planar walls modified by tethered chain molecules using density functional theory. The molecules are modeled as spheres composed of a hydrophilic and hydrophobic part. The pinned chains are treated as tangentially jointed spheres that can interact with fluid molecules via ...
Moubarac Jean-Claude - - 2013
OBJECTIVE: The present study describes the consumption patterns of sweetened food and drink products in a Catholic Middle Eastern Canadian community and examines its associations with physical activity, sedentary behaviours and BMI. DESIGN: A two-stage cross-sectional design was used. In Stage 1 (n 42), 24 h recalls enabled the identification ...
Würslin Christian - - 2013
Hybrid PET/MR combines the exceptional molecular sensitivity of PET with the high resolution and versatility of MR imaging. Simultaneous data acquisition additionally promises the use of MR to enhance the quality of PET images, for example, by respiratory motion correction. This advantage is especially relevant in thoracic and abdominal areas ...
Kokubo Hiroki - - 2013
OBJECTIVE: Acquired heart diseases, such as valve disease, are major causes of human morbidity and mortality. However, the pathological mechanisms underlying these diseases are largely unknown. Our aim is to identify the role of the hairy and enhancer of split-related (Hesr)-2 gene in the adult heart. METHODS AND RESULTS: Echocardiography ...
Koc Mustafa - - 2013
Abstract This study explored Facebook addiction among Turkish college students and its behavioral, demographic, and psychological health predictors. The Facebook Addiction Scale (FAS) was developed and its construct validity was assessed through factor analyses. A total of 447 students reported their personal information and Facebook usage and completed the FAS ...
Mahmood Fareeha - - 2013
Pseudomonas aeruginosa is an important opportunistic bacterial pathogen. Despite its metabolic and virulence versatility, it has not been shown to infect articular joints, which are environments that are rarely infected with bacteria in general. We hypothesized that articular joints possess antimicrobial activity that limits bacterial survival in these environments. We ...
Dufek Matthew B - - 2013
P-glycoprotein (P-gp) and CYP3A/Cyp3a in the intestine can attenuate absorption of orally administered drugs. While some suggest that P-gp enhances intestinal metabolism by CYP3A/Cyp3a during absorption of a dual substrate, others suggest that P-gp reduces the metabolism in the intestine when substrates are at sub-saturating concentrations. Hence, to elucidate the ...
Dunbar Kyle L - - 2013
Ribosomally synthesized posttranslationally modified peptides (RiPPs) are a rapidly growing class of natural products with diverse structures and activities. In recent years, a great deal of progress has been made in elucidating the biosynthesis of various RiPP family members. As with the study of nonribosomal peptide and polyketide biosynthetic enzymes, ...
Nielsen Maj Britt D - - 2013
Introduction: The aims of this paper were to examine how disabled workers assess encounters with return-to-work (RTW) stakeholders during sickness absence due to common mental disorders (CMD) and to investigate gender differences in these assessments. Method: Data on contact with and assessment of encounters with RTW-stakeholders were obtained from a ...
Zhao Chongchao - - 2013
A new series of complexes containing two electron donating groups, {M(CO)(3)}(+) ions, M = Re or Mn, on one polytungstate electron acceptor group have been prepared and characterized. These complexes containing two electron donating groups, {M(CO)(3)}(+) ions, M = Re or Mn, on one polytungstate electron acceptor group have been ...
Conway William Owen - - 2013
Piperazine (PZ) is widely recognised as a promising solvent for post combustion capture (PCC) of carbon dioxide (CO2). In view of the highly conflicting data describing the kinetic reactions of CO2(aq) in piperazine solutions, the present study focuses on the identification of the chemical mechanism, specifically the kinetic pathways for ...
Son Jang Won - - 2013
Objectives. The aim of this study was to evaluate the effects of early intensive insulin therapy on body fat distribution, lean body mass and β-cell function in patients with newly diagnosed type 2 diabetes. Methods. Thirty-eight subjects with newly diagnosed type 2 diabetes participated in a 12-week course of intensive ...
Hsieh Y-C - - 2013
INTRODUCTION: Large granular lymphocytes (LGLs) are medium- to large-sized lymphocytes with azurophilic cytoplasmic granules. Reactive vs. neoplastic LGLs are usually morphologically indistinguishable. METHODS: We investigated 25 consecutive cases of LGL lymphoproliferation using flow cytometric T cell receptor Vβ (FC-Vβ) repertoire and T cell receptor gene rearrangement (TCR-GR) in detecting clonality. ...
Mauri Arabella - - 2013
Tissue engineering is aimed at the fabrication of autologous cardiovascular implants, for example, heart valves or vascular grafts. To date, the mechanical characterization of tissue-engineered vascular grafts (TEVGs) has focused mainly on the material's strength and not on the deformation behavior. A total of 31 samples obtained from 3 mature ...
Barh Debmalya - - 2013
Although attempts have been made to unveil protein-protein and host-pathogen interactions based on molecular insights of important biological events and pathogenesis in various organisms, these efforts have not yet been reported in Corynebacterium pseudotuberculosis (Cp), the causative agent of Caseous Lymphadenitis (CLA). In this study, we used computational approaches to ...
Moreno Juan A - - 2013
OBJECTIVE: High-mobility group box 1 (HMGB1), a DNA-binding cytokine expressed mainly by macrophages, contributes to lesion progression and chronic inflammation within atherosclerotic plaque. It has been suggested that different cytokines could regulate HMGB1 expression in monocytes. We have analyzed the effect of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) ...
Liu Chen-Wei - - 2013
In this paper, a facile strategy to develop graphene-based delivery nanosystems for effective drug loading and sustained drug release was proposed and validated. Specifically, biocompatible naphthalene-terminated PEG (NP) and anticancer drugs (curcumin or doxorubicin (DOX)) were simultaneously integrated onto oxidized graphene (GO) , leading to self-assembled, nano-sized complexes. It was ...
Ferenczy György G - - 2013
The application of the local basis equation (Ferenczy and Adams, J. Chem. Phys. 2009, 130, 134108) in mixed quantum mechanics/molecular mechanics (QM/MM) and quantum mechanics/quantum mechanics (QM/QM) methods is investigated. This equation is suitable to derive local basis nonorthogonal orbitals that minimize the energy of the system and it exhibits ...
Peng Li - - 2013
Poring over polymers: Highly porous polymers with hierarchical macro- and mesoporous structures were synthesized by using the title method and UV radiation. The porosity properties of the polymers can be easily tuned by controlling the CO(2) pressure used, and the polymers have potential applications in catalysis. IL=ionic liquid, PAM=polyacrylamide.
Sripirom Jiyapa - - 2013
Carbon tips for in situ scanning tunneling microscopy studies in an electrochemical environment were prepared by electrochemical etching of carbon fibers and subsequent coating with electrodeposition paint and a silicone elastomer. The tips obtained were stable in acidic electrolyte and allowed high-resolution in situ imaging of the bare Au(111) electrode ...
Hutton Paul - - 2013
Background: More effective psychological treatments for psychosis are required. Case series data and pilot trials suggest metacognitive therapy (MCT) is a promising treatment for anxiety and depression. Other research has found negative metacognitive beliefs and thought-control strategies may be involved in the development and maintenance of hallucinations and delusions. The ...
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