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Results 301 - 350 of 2749
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Mc Ardle B A - - 2013
Cardiac sarcoidosis (CS) has gained significant interest in recent years with the emergence of advanced imaging modalities such as MRI and F(18)-fluorodeoxyglucose-positron emission tomography (FDG-PET) as modalities to aid in the diagnosis of this condition. CS remains a difficult condition to diagnose, particularly in cases of isolated cardiac involvement and ...
Tractenberg Rochelle E - - 2013
Multiple choice (MC) questions from a graduate physiology course were evaluated by cognitive-psychology (but not physiology) experts, and analyzed statistically, in order to test the independence of content expertise and cognitive complexity ratings of MC items. Integration of higher order thinking into MC exams is important, but widely known to ...
Khalifa Tarek - - 2013
The aim of this experiment was to study the effect of semen extender on sperm chromatin structure and to correlate chromatin integrity with field-fertility of preserved ram semen. Ejaculates of at least 2 × 10(9) sperm/ml and 70 % progressive motility were collected using an artificial vagina from Chios rams (n = 11, 4-6 years old), split-diluted ...
Chen Haw-Wen - - 2013
Matrix metalloproteinase-9 (MMP-9) plays a crucial role in tumor metastasis. Previous studies showed that polyunsaturated fatty acids exhibit an anti-cancer effect in various human carcinoma cells, but the effect of docosahexaenoic acid (DHA) and linoleic acid (LA) on metastasis of breast cancer cells is not fully clarified. We studied the ...
Sjerps Matthias J - - 2013
Three experiments investigated whether extrinsic vowel normalization takes place largely at a categorical or a precategorical level of processing. Traditional vowel normalization effects in categorization were replicated in Experiment 1: Vowels taken from an [ɪ]-[ε] continuum were more often interpreted as /ɪ/ (which has a low first formant, F (1)) ...
Vreugdenburg Thomas D - - 2013
The objective of this study aimed to systematically identify and evaluate all the available evidence of safety, effectiveness and diagnostic accuracy for three emerging classes of technology promoted for breast cancer screening and diagnosis: Digital infrared thermal imaging (DITI), electrical impedance scanning (EIS) and elastography. A systematic search of seven ...
Wheeldon Linda - - 2013
Three sentence production experiments investigate the relationship between lexical and structural processing scope. Speakers generated sentences with varying phrase structures in response to visual displays (e.g., The dog and the hat move above the fork and the tree/The dog moves above the hat and the fork and the tree). On ...
Conway Justin W - - 2013
Simple chemical modifications to oligonucleotide ends with hexaethylene glycol and hexanediol are shown to significantly increase nuclease resistance under serum conditions. The modified oligonucleotides were used to construct DNA prismatic cages in a single step and in quantitative yield. These cages further stabilize their strands towards nucleases, with lifetimes of ...
Thomas Vernon George - - 2013
Proposals to end the use of lead hunting ammunition because of the established risks of lead exposure to wildlife and humans are impeded by concerns about the availability, price, and effectiveness of substitutes. The product availability and retail prices of different calibers of lead-free bullets and center-fire rifle ammunition were ...
Popp Lothar - - 2013
PURPOSE: Combined rectal and vaginal prolapse requires a complete repair of the pelvic floor that can only be achieved by an interdisciplinary management. We have, therefore, established a co-operation for preoperative diagnosis, interdisciplinary operations, and postoperative care involving a colorectal surgeon and a gynecologist. METHODS: Our standardized operation, which we ...
El Cadore - - 2013
The purpose of the present study was to review the scientific literature that investigated concurrent training adaptations in elderly populations, with the aim of identifying the optimal combination of both training program variables (i.e., strength and endurance) to avoid or minimize the interference effect in the elderly. Scielo, Science Citation ...
Falzone Elisabeth - - 2013
Elderly people represent the fastest-growing segment of our society and undergo surgery more frequently than other age groups. Effective postoperative analgesia is essential in these patients because inadequate pain control after surgery is associated with adverse outcomes in elderly patients. However, management of postoperative pain in older patients may be ...
Woo Sang Myung - - 2013
BACKGROUND: Few clinical studies to date have compared different types of self-expandable metallic stents (SEMS) and their outcomes in patients with pure duodenal obstruction caused by pancreaticobiliary cancer. The aim of this study was to compare the clinical effectiveness and side effects of uncovered and covered SEMS for the palliation ...
Lee Joo-Young - - 2013
Corynebacterium glutamicum was adapted in a chemostat for 1,900 h with gradually increasing H(2)O(2) stress to understand the oxidative stress response of an industrial host. After 411 generations of adaptation, C. glutamicum developed the ability to grow under stress of 10 mM H(2)O(2), whereas the wild-type did not. The adapted strain also ...
Mellor James D - - 2013
ABSTRACT: Antibody-dependent cellular cytotoxicity (ADCC) is a major mechanism of action of therapeutic monoclonal antibodies (mAbs) such as cetuximab, rituximab and trastuzumab. Fc gamma receptors (FcgR) on human white blood cells are an integral part of the ADCC pathway. Differential response to therapeutic mAbs has been reported to correlate with ...
Heng Eng Chee - - 2013
PURPOSE: Tocotrienol possess beneficial effects not exhibited by tocopherol. In vitro studies using animal models have suggested that these effects are caused via modulation of gene and protein expression. However, human supplementation studies using tocotrienol-rich isomers are limited. This study aims to identify plasma proteins that changed in expression following ...
Bryś Magdalena - - 2013
The biological behavior of prostate cancer is uncertain, and therefore, search for molecular prognostic markers associated with disease progression seems to be essential. We performed microsatellite allelotyping of DNA isolated from primary prostate tumors biopsies (prostate adenocarcinoma, PCa). We evaluated the frequency of allelic imbalance (AI), including loss of heterozygosity ...
Marradi Marco - - 2013
The quest for the construction of multivalent carbohydrate systems, with precise geometries that are highly efficient in interacting with carbohydrate binding proteins, has been a goal of synthetic chemists since the discovery of the multivalent nature of carbohydrate-mediated interactions. However, the control of the spatial and topological requirements for these ...
Schulz Christian - - 2013
ABSTRACT: BACKGROUND: By 2013 Palliative Care will become a mandatory examination subject in the medical curriculum in Germany. There is a pressing need for effective and well-designed curricula and assessment methods. Debates are on going as how Undergraduate Palliative Care Education (UPCE) should be taught and how knowledge and skills ...
Pawani Harsha - - 2013
Human embryonic stem cells (hESCs) have the ability to differentiate into all the three lineages and are an ideal starting material to obtain cells of desired lineage for regenerative medicine. Continued efforts are needed to evolve more robust protocols to obtain cells of desired lineages and in larger numbers. Also, ...
Guo Xiaola - - 2013
Control of organ size by cell expansion and cell proliferation is a fundamental process during development, but the importance of BIG in this process is still poorly understood. Here, we report the isolation and characterization of a new allele mutant of BIG in Arabidopsis: big-j588. The mutant displayed small aerial ...
Kapetanovic Meliha C - - 2013
ABSTRACT: INTRODUCTION: The aim of this study is to explore the persistence of antibody response 1.5 years after vaccination using 7-valent pneumococcal conjugate vaccine in patients with rheumatoid arthritis (RA) or spondylarthropathy (SpA) treated with different anti-rheumatic drugs. METHODS: Of 505 patients initially recruited, data on current anti-rheumatic treatment and ...
Kimmel Gary L - - 2013
The herbicide glyphosate has undergone multiple safety tests for developmental toxicity in rats and rabbits. The European Commission's 2002 review of available glyphosate data discusses specific heart defects observed in several individual rabbit developmental toxicity studies, but describes the evidence for a potential causal relationship as equivocal. The present assessment ...
Bhutani Divaya - - 2013
Over the last decade, the field of oncology has undergone revolutionary changes. One of the major reasons contributing to this change is the improvement in our understanding of the biology of cancer. Recognition of novel targets on the cancer cell has enabled development of tools to attack those targets. Monoclonal ...
Xavier Rui - - 2013
The delivery approach, though very appropriate for remodeling the tip of the nose, has been overlooked in recent years and has often been passed over for the open approach. One reason for this is the intercartilaginous incision used for the delivery approach, which may cause scarring at the nasal valve ...
Fraczek Joanna - - 2013
Vorinostat and romidepsin were the first histone deacetylase (HDAC) inhibitors (HDi) that fulfilled the preclinical promise of anticancer potential in clinical trials. Nevertheless, they merely opened a new chapter in the history of cancer therapy. Demonstration of their antitumor activity was a straightforward task in in vitro setting. Proving their ...
Chaput B - - 2013
Prophylactic mastectomies have increased during the last 10 years. Breast reconstructions with free flaps are performed because they provide natural and long-lasting results. In bilateral mastectomy, a simultaneous bilateral superior gluteal artery perforator (SGAP) flap can provide good reconstruction with autologous tissue and low donor-site morbidity. This report describes the case ...
Karacı S - - 2013
Reduction mammaplasty is one of the most frequently performed operations in plastic surgery. Breast scarring can be troublesome for both the patient and the surgeon. This report offers an easy method for suturing a vertical incision that provides a better shape in final breast appearance. In this study, 10 patients ...
Murphy Siun - - 2013
The recent observation of anaplastic large cell lymphoma (ALCL) in association with breast implants has initiated a large amount of literature recently, particularly in light of the issues with Poly Implant Prosthese implants. There are now approximately 35-50 reports of this lymphoma associated with breast implants. One of the presenting ...
Yang Yue - - 2013
Water displacement plays critical role in several phases of drug discovery. Proper treatment of displacing water could improve enrichment in virtual screening and could lead to more successes in lead optimization. WaterMap has recently emerged as a promising approach in this regard; recent implementations of this protocol successfully explained various ...
Karl Jenni M JM Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, T1K 3M4, Canada. - - 2013
The Dual Visuomotor Channel theory proposes that skilled reaching is composed of a Reach that directs the hand in relation to the extrinsic properties of an object (e.g., location) and a Grasp that opens and closes the hand in relation to the intrinsic properties of an object (e.g., size). While ...
Forn C C Departament Psicología Bàsica, Clínica i Psicobiología, Fac. Ciències de la Salut, Universitat Jaume I, Campus Riu Sec, Castelló de la Plana, Spain. - - 2013
An abnormal pattern of brain activations has been shown in patients with multiple sclerosis during the performance of several cognitive tasks. The aim of this study is to investigate abnormalities of the patterns of activation/deactivation in the functional networks related to "task-positive" and "task-negative" events during the execution of the ...
Hackney Amy L AL Department of Kinesiology and Physical Education, Wilfrid Laurier University, 75 University Ave, W., Waterloo, ON, - - 2013
Young and older adults demonstrate differences in action when passing through confined spaces (Warren and Whang in J Exp Psychol Hum Percept Perform 13:371-383, 1987; Hackney and Cinelli in Gait Posture 33:733-736, 2011). However, it is unknown whether or not these differences in actions exist during non-confined multiple obstacle avoidance ...
Mirza Sameer S Department of Genetics, Cell Biology & Anatomy, University of Nebraska Medical Center, Omaha, NE 68198-5805, - - 2013
Transcriptional activation by estrogen receptor (ER) is a key step to breast oncogenesis. Given previous findings that ADA3 is a critical component of HAT complexes that regulate ER function and evidence that overexpression of other ER coactivators such as SRC-3 is associated with clinical outcomes in breast cancer, the current ...
Fitzgerald Desmond J DJ UCD Conway Institute and Java Clinical Research, University College Dublin, - - 2013
The development of drugs that inhibit platelets has been driven by a combination of clinical insights, fundamental science, and sheer luck. The process has evolved as the days of stumbling on therapeutic gems, such as aspirin, have long passed and have been replaced by an arduous process in which a ...
Seidl Roman R Institute for Environmental Decisions, ETH Zurich, Zurich, Switzerland. - - 2013
Interdisciplinary scientific knowledge is necessary but not sufficient when it comes to addressing sustainable transformations, as science increasingly has to deal with normative and value-related issues. A systems perspective on coupled human-environmental systems (HES) helps to address the inherent complexities. Additionally, a thorough interaction between science and society (i.e., transdisciplinarity = TD) ...
Meeney A A National Specialist Ophthalmic Pathology Service (NSOPS), Department of Histopathology, Royal Hallamshire Hospital, Sheffield, UK. - - 2013
The advanced specialist diploma in ophthalmic pathology was jointly ratified by the Royal College of Pathologists and the Institute of Biomedical Science in 2008. It results in extended roles for suitably qualified Biomedical Scientists (BMSs) in ophthalmic pathology specimen dissection and histological reporting of selected specimens, specifically non-neoplastic corneas. This ...
Mihai Gazdag Emerich E Max-Planck-Institute of Molecular Physiology, Department of Physical Biochemistry, Dortmund 44227, - - 2013
Legionella pneumophila is an intracellularly surviving pathogen that releases about 270 different proteins into the host cell during infection. A set of secreted proteins takes control of the vesicular trafficking regulator Rab1. Legionella LepB inactivates Rab1 by acting as a GTPase-activating protein (GAP). We present the crystal structure of the ...
Lo Christine C Academic Unit of Neurology, Sheffield Institute for Translational Neuroscience (SITraN), 385a Glossop Road, Sheffield, - - 2013
Abstract We present a case of concurrent cystic fibrosis (CF) and amyotrophic lateral sclerosis (ALS). To our knowledge this is the first reported coincidence of these two diseases. Although TDP-43 dysfunction has been linked to both pathologies, it does not appear to be pivotal in this individual who does not ...
Carta Mario M Université Bordeaux, Institut Interdisciplinaire de Neurosciences, UMR 5297, Bordeaux, - - 2013
Calmodulin-dependent kinase II (CaMKII) is key for long-term potentiation of synaptic AMPA receptors. Whether CaMKII is involved in activity-dependent plasticity of other ionotropic glutamate receptors is unknown. We show that repeated pairing of pre- and postsynaptic stimulation at hippocampal mossy fibre synapses induces long-term depression of kainate receptor (KAR)-mediated responses, ...
Shao Hongwei H Methodist Hospital Research Institute, 6670 Bertner Avenue, Houston, - - 2013
Amyotrophic lateral sclerosis (ALS) is a devastating and chronic neurodegenerative disease without any known cure. In the brain and spinal cord of both patients and animal models with ALS, neuroinflammation is a prominent pathological hallmark which is characterized by infiltrating T cells at sites of motor neuron injury. Their presence ...
Cole Zachary Douglas ZD Tourism, Recreation, and Sport Management, University of Florida, PO Box 118208, Gainesville, FL 32611, USA. - - 2013
The interactive capacity of the Internet offers benefits that are intimately linked with contemporary research innovation in the natural resource and environmental studies domains. However, e-research methodologies, such as the e-Delphi technique, have yet to undergo critical review. This study advances methodological discourse on the e-Delphi technique by critically assessing ...
Shellman Erin R ER Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, - - 2013
Motifs are repeating patterns that determine the local properties of networks. In this work, we characterized all 3-node motifs using enzyme commission numbers of the International Union of Biochemistry and Molecular Biology to show that motif abundance is related to biochemical function. Further, we present a comparative analysis of motif ...
Evans Nicholas Rhys NR Cardiff School of Engineering, Cardiff University, Queen's Buildings, The Parade, Cardiff, CF24 3AA, UK. - - 2013
To compare the effectiveness of the Aspen, Aspen Vista, Philadelphia, Miami-J and Miami-J Advanced collars at restricting cervical spine movement in the sagittal, coronal and axial planes. Nineteen healthy volunteers (12 female, 7 male) were recruited to the study. Collars were fitted by an approved physiotherapist. Eight ProReflex (Qualisys, Sweden) ...
Bastos Filho Ricardo R Department of Orthopaedic Surgery, Hôpital de la Croix-Rousse, Centre Albert Trillat, Lyon, - - 2013
High tibial osteotomy (HTO) is frequently used to treat varus osteoarthritis in younger patients with the goal of delaying the need for total knee arthroplasty (TKA). While it has been reported that the results of TKA following HTO are worse than those in patients without prior knee surgery, the influence ...
Schepers Tim T Department of Surgery-Traumatology, Erasmus MC, University Medical Center Rotterdam, Room H-822k, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands. - - 2013
Information about the influence of delayed surgery on infectious wound complications is ambiguous. A clinical audit was performed to test the hypothesis that early surgery lowers the rate of infectious wound complications. Secondly we looked at the influence of surgical delay and complications on patient reported functional outcome. All consecutive, ...
Papastefanou V P VP Ocular Oncology Service, Moorfields Eye Hospital, London, - - 2013
To describe the results of photodynamic therapy (PDT) for juxtapapillary and peripheral retinal capillary hemangioma (RCH). Interventional case series of four eyes (four patients) with juxtapapillary RCH and one eye (one patient) with peripheral RCH. Two eyes with juxtapapillary RCH had received two sessions of full-fluence, double-duration PDT; whereas other ...
Fang Y-T YT Institute of Health and Welfare Policy, National Yang-Ming University, Taipei, - - 2013
This study was conducted to examine the atropine eye drop prescription trend for children diagnosed with myopia, and to determine the factors associated with the prescription of atropine eye drops. This was a population-based cross-sectional study. This study was conducted using a national representative sample from the National Health Insurance ...
Solnik Stanislaw S Department of Kinesiology, The Pennsylvania State University, 20, Recreation Building, University Park, PA 16802, USA. - - 2013
This study joined two approaches to motor control. The first approach comes from cognitive psychology and is based on the idea that goal postures and movements are chosen to satisfy task-specific constraints. The second approach comes from the principle of motor abundance and is based on the idea that control ...
De Salvo G G Southampton Eye Unit, University Hospital Southampton, Southampton, - - 2013
To describe two cases of retinal angiomatous proliferation (RAP)-like lesion following radiation therapy for primary tumor. Retrospective evaluation of two patients with previous irradiation treatment for a pleomorphic adenoma of the lacrimal gland and a vocal cord carcinoma, respectively. Visual acuity (VA), fluorescein angiography and optical coherence tomography were performed ...
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