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Results 301 - 350 of 2749
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Isomoto Nana - - 2013
In the early stages of the hypothetical RNA world, some primitive RNA catalysts (ribozymes) may have emerged through self-assembly of short RNA oligomers. Although they may be unstable against temperature fluctuations and other environmental changes, ligase ribozymes (ribozymes with RNA strand-joining activity) may resolve structural instability of self-assembling RNAs by ...
Jeschke Steffen - - 2013
Novel liquid disiloxanes, containing an n-propylic spacer group between the disiloxane fragment and a cyclic or non-cyclic carbamate moiety, were synthesized and characterized as liquid electrolytes. The ionic conductivity, thermal properties, viscosity and relative permittivity of these new solvents have been investigated, taking into account steric factors.
Cogliati Massimo - - 2013
Cryptococcus neoformans variety grubii is the major etiological agent of cryptococcal meningitis in both immunocompromised and immunocompetent patients. The current PCR-based molecular methods are not sufficient to discriminate among the different populations of this yeast. Therefore, the aim of the present study was to investigate the genotypes of the Italian ...
Park Hee-Young - - 2013
Electrocatalysts for hydrogen oxidation reactions (HORs) are the key to renewable-energy technologies including fuel cells, hydrogen pumps, and water splitting. Despite the significant technological interest and tremendous efforts that have been made, development of hydrogen electrode catalysts with high activity at low cost remains a great challenge. Here, we report ...
Niva Camilla - - 2013
PURPOSE: To date, γ-secretase inhibition is the most frequently studied mechanism of reducing Aβ in clinical trials with as yet no therapeutic success for AD patients, as measured by the slowing down of cognitive decline or an improvement in cognitive function. The aims of this investigation were to evaluate whether ...
Solnik Stanislaw S Department of Kinesiology, The Pennsylvania State University, 20, Recreation Building, University Park, PA 16802, USA. - - 2013
This study joined two approaches to motor control. The first approach comes from cognitive psychology and is based on the idea that goal postures and movements are chosen to satisfy task-specific constraints. The second approach comes from the principle of motor abundance and is based on the idea that control ...
Bonate Peter L - - 2013
Monte Carlo simulation was used to assess the performance of linear mixed effect models (LMEMs) to characterize the concentration-effect relationship when both parent and metabolite concentrations were available. Parent and metabolite concentrations were simulated under an experimental design that mimicked a thorough QT study. Simulations were done where both parent ...
Vrijsen Bart - - 2013
Non-invasive ventilation (NIV) is widely used to improve alveolar hypoventilation in amyotrophic lateral sclerosis. Several studies indicate a better survival when NIV is used, certainly in patients with none to moderate bulbar dysfunction. Data on quality of life (QoL) are rather disputable. Overall QoL is shown to be equivalent in ...
Cañas Fernando - - 2013
Partial and non-adherence to medication is a common problem in schizophrenia, leading to an increased risk of relapse, increased likelihood of hospitalization and poorer long-term outcomes. In contrast, continuous medication in the treatment of schizophrenia is associated with positive outcomes, including improved clinical status, improved quality of life and functioning, ...
Sun Shi-Fang - - 2013
Vascular endothelial growth factor (VEGF) is a major regulator of angiogenesis in the process of tumor growth and metastasis. Different VEGF gene polymorphisms have been shown to result in different VEGF protein expression in cancer cells and tumor angiogenic activity. We conducted a case-control study to evaluate the genetic effects ...
Downie R A - - 2013
Thermoelectric figures of merit, ZT > 0.5, have been obtained in arc-melted TiNiSn-based ingots. This promising conversion efficiency is due to a low lattice thermal conductivity, which is attributed to excess nickel in the half-Heusler structure.
Vijayalakshmi Poreddi - - 2013
The present descriptive study investigated the impact of socio-economic status in meeting the human rights needs among randomly selected recovered psychiatric patients (n = 100) at a tertiary care center. Data was collected through face to face interview, using structured Needs Assessment Questionnaire. The findings revealed that the participants from below poverty ...
Saur Lisiani - - 2013
Physical exercise has an important influence on brain plasticity, which affects the neuron-glia interaction. Astrocytes are susceptible to plasticity, and induce and stabilize synapses, regulate the concentration of various molecules, and support neuronal energy metabolism. The aim of our study was to investigate whether physical exercise is capable of altering ...
Kang Xiangdong - - 2013
The reversible dehydrogenation properties of the 2LiBH(4)-MgH(2) composite can be effectively improved by incorporating heterogeneous nucleation agents, typically transition metal borides. A careful study of the 2LiBH(4)-MgH(2) composite with a titanium trifluoride (TiF(3)) additive finds that using the conventional one-step milling method renders only a partial conversion from TiF(3) to ...
Wang Yanyan - - 2013
In this paper, the fabrication, characterization and application in oxygen sensing are reported for a novel multifunctional nanomaterial of [Ru(bpy)2phen-MMS] (bpy: 2,2'-bipyridyl, phen: phenathrolin) which was simply prepared by covalently grafting the ruthenium(II) polypyridyl compounds into the channels of magnetic mesoporous silica nanocomposites (MMS). Scanning electron microscopy (SEM), transmission electron ...
Kim Heejin - - 2013
A novel hierarchical ZnO nanostructure array composed of nanosheet branched (NB) ZnO nanorods (NRs) has been fabricated using a two-step solution reaction. The obtained nanosheet branched (NB) ZnO nanorods (NRs) exhibited considerably enhanced light capturing compared with ZnO thin films and ZnO nanorods. This combined 2D (nanosheet) and 1D (nanorod) ...
Xie Song-Tao - - 2013
The generation of induced neuronal cells from human bone marrow stromal stem cells (hBMSCs) provides new avenues for basic research and potential transplantation therapies for nerve injury and neurological disorders. However, clinical application must seriously consider the risk of tumor formation by hBMSCs, neural differentiation efficiency and biofunctions resembling neurons. ...
Kwon Kyung-Hoon - - 2013
Human chromosome 11 is the third gene-rich chromosome having 1304 protein-coding genes. According to the GeneCards, this chromosome contains 240 genes related to diseases, as it is well known as a disease-rich chromosome. Although there are many protein-coding genes, the proteomic identification ratio is rather low. As a model study, ...
Liu Jie - - 2013
To individually optimize contrast medium protocol for high-pitch prospective ECG-triggering coronary CT angiography using body weight. Ninety patients undergoing high-pitch coronary CT angiography were randomly assigned to 3 contrast medium injection protocols with bolus tracking technique: Group A, 0.7 ml CM per kg patient weight (ml/kg); Group B, 0.6 ml/kg; Group C, ...
Liuzza Marco Tullio - - 2013
Although considered a predominantly automatic social behaviour, gaze following (GF) is sensitive to complex social factors like political affiliation and ideology. The present study aimed to determine whether the differential proneness to in-group leaders' gaze is related to attitudes towards politicians as measured by other implicit procedures. A GF paradigm ...
Kronish Ian M IM Center for Behavioral Cardiovascular Health, Columbia University Medical Center, New York, NY, USA. - - 2013
Even though medications can greatly reduce the risk of recurrent stroke, medication adherence is suboptimal in stroke survivors. To identify key barriers to medication adherence in a predominantly low-income, minority group of stroke and transient ischemic attack (TIA) survivors. Cross-sectional study. Six hundred stroke or TIA survivors, age ≥ 40 ...
Fèvre Maréva - - 2013
The chemistry of N-heterocyclic carbenes (NHCs) has witnessed tremendous development in the past two decades: NHCs have not only become versatile ligands for transition metals, but have also emerged as powerful organic catalysts in molecular chemistry and, more recently, in metal-free polymer synthesis. To understand the success of NHCs, this ...
Pepek Joseph M - - 2013
ABSTRACT: BACKGROUND: To examine toxicity and outcomes for patients treated with preoperative chemoradiotherapy (CRT) for gastric cancer. METHODS: Patients with gastroesophageal (GE) junction (Siewert type II and III) or gastric adenocarcinoma who underwent neoadjuvant CRT followed by planned surgical resection at Duke University between 1987 and 2009 were reviewed. Overall ...
Pendyala Brahmaiah - - 2013
CYP102A5 variant (ADL27534) from isolated Bacillus cereus CYPPB-1 was heterologously expressed in Escherichia coli Top 10 cells. Comparative sequence analysis of purified CYP102A5 variant with respect to reported CYP102A5 (AAP10153) from Bacillus cereus ATCC 14579 revealed amino acid sequence changes at positions P245S and M318I of heme domain. The binding ...
Shirai Mikiyasu - - 2013
Synchrotron radiation (SR) is increasingly being used for micro-level and nano-level functional imaging in in vivo animal experiments. This review focuses on the methodology that enables repeated and regional assessment of vessel internal diameter and flow in the resistance vessels of different organ systems. In particular, SR absorption microangiography approaches ...
Barrio-Cantalejo Ines M - - 2013
Objective: To measure the stability of life-sustaining treatment preferences amongst older people and analyse the factors that influence stability. Design: Longitudinal cohort study. Setting: Primary care centres, Granada (Spain). Eighty-five persons age 65 years or older. Participants filled out a questionnaire with six contexts of illness (LSPQ-e). They had to decide ...
Uchino Haruto - - 2013
BACKGROUND: Postoperative hyperperfusion may lead to severe neurological complications after superficial temporal artery to middle cerebral artery (STA-MCA) anastomosis. However, there are no reliable modalities to predict the occurrence of postoperative hyperperfusion during surgery. The purpose of this study is to evaluate whether a semiquantitative analysis of indocyanine green (ICG) ...
Yang Yu-Qiang - - 2013
The high salinity and fat contents of kitchen waste (KW) inhibits the effect of two-phase anaerobic digestion system. This research introduces fruit-vegetable waste (FVW) to alleviate the inhibition effect caused by salinity and fat concentrations, and tries to achieve an optimal addition ratio of FVW, an optimal hydraulic remain time ...
Liu Ying-Jian - - 2013
There are limitations in the diagnosis of thyroid nodules, especially follicular lesions, and their pathogenesis remains unclear. Insulin-like growth factor-1 (IGF-1) has been implicated in tumor cell apoptosis, transformation, invasion, and metastasis; however, its role in thyroid nodules is undetermined. The aim of this study is to investigate the relationship ...
Goswami Santosh V - - 2013
We have developed an efficient protocol for the synthesis of [Formula: see text]-amino carbonyl compounds using phenylboronic acid as effective and eco-friendly catalyst via one-pot three-component Mannich reaction. Excellent yields, mild reaction condition, and simple experimental work-up procedure are some of the advantages of this method, which makes it a ...
Bhagat Shaishav S Department of Orthopaedic Surgery, Norfolk and Norwich University Hospital, Colney lane, Norwich, Norfolk, NR4 7UY, UK. - - 2013
This study analyses the complications of spinal deformity surgery in adults to highlight pre-disposing factors. The clinical records and imaging were reviewed for 48 consecutive patients, 12 males and 36 females, with a mean age of 64 (31-86), who had surgery for spinal deformity. Mean follow-up time was 36 months ...
Molzberger Almut F - - 2013
Isoflavone (ISO) exposure during adolescence has been demonstrated to modulate the estrogenic and proliferative sensitivity of the adult breast tissue. In this study, we investigated whether ISO exposure restricted to the period of puberty is sufficient to result in similar effects. Female rats were divided into three groups receiving either ...
Bastos Filho Ricardo R Department of Orthopaedic Surgery, Hôpital de la Croix-Rousse, Centre Albert Trillat, Lyon, - - 2013
High tibial osteotomy (HTO) is frequently used to treat varus osteoarthritis in younger patients with the goal of delaying the need for total knee arthroplasty (TKA). While it has been reported that the results of TKA following HTO are worse than those in patients without prior knee surgery, the influence ...
Pritchard Justin R JR Department of Biology M.I.T., Cambridge, MA, - - 2013
Molecular signatures are a powerful approach to characterize novel small molecules and derivatized small molecule libraries. While new experimental techniques are being developed in diverse model systems, informatics approaches lag behind these exciting advances. We propose an analysis pipeline for signature based drug annotation. We develop an integrated strategy, utilizing ...
Malic Lidija - - 2013
Early and accurate disease diagnosis still remains a major challenge in clinical settings. Biomarkers could potentially provide useful tools for the detection and monitoring of disease progression, treatment safety and efficacy. Recent years have witnessed prodigious advancement in biosensor development with research directed towards rapid, real-time, label-free and sensitive biomarker ...
Forn C C Departament Psicología Bàsica, Clínica i Psicobiología, Fac. Ciències de la Salut, Universitat Jaume I, Campus Riu Sec, Castelló de la Plana, Spain. - - 2013
An abnormal pattern of brain activations has been shown in patients with multiple sclerosis during the performance of several cognitive tasks. The aim of this study is to investigate abnormalities of the patterns of activation/deactivation in the functional networks related to "task-positive" and "task-negative" events during the execution of the ...
Stancher Gionata - - 2013
Discrimination of quantity has been argued to rely on two non-verbal representational systems: an object file system (OFS) for representing small values (≤3-4) and an analog magnitude system (AMS) for representing large magnitudes (>4). Infants' ability to discriminate 1 versus 2, 1 versus 3, 2 versus 3, but not 1 ...
Forrester J V JV Institute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, UK. - - 2013
Inflammation, in the pathogenesis of many diseases previously thought to be strictly genetic, degenerative, metabolic, or endocrinologic in aetiology, has gradually entered the framework of a general mechanism of disease. This is exemplified by conditions such as Parkinson's disease, Alzheimer's disease, atherosclerosis, diabetes, and the more recently described Metabolic Syndrome. ...
Madeira Marta S - - 2013
The present study assessed the effect of pig genotype (fatty v. lean) and dietary protein and lysine (Lys) levels (normal v. reduced) on intramuscular fat (IMF) content, subcutaneous adipose tissue (SAT) deposition, fatty acid composition and mRNA levels of genes controlling lipid metabolism. The experiment was conducted on sixty intact ...
Balli David D Department of Pediatrics, Division of Pulmonary Biology, The Perinatal Institute, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, - - 2013
Alveolar epithelial cells (AECs) participate in the pathogenesis of pulmonary fibrosis, producing pro-inflammatory mediators and undergoing epithelial-to-mesenchymal transition (EMT). Herein, we demonstrated the critical role of Forkhead Box M1 (Foxm1) transcription factor in radiation-induced pulmonary fibrosis. Foxm1 was induced in AECs following lung irradiation. Transgenic expression of an activated Foxm1 ...
Nivison-Smith Ian - - 2013
ABSTRACT This population registry-based study followed all cases of myeloma diagnosed in New South Wales Australia during 2002 to 2005 and compared survival outcomes of those who proceeded to autologous hematopoietic cell transplant (HCT) with those who did not. Data available consisted of demographic details and survival, and did not ...
Rahman Mosiur - - 2013
Objectives To estimate (i) lifetime prevalence of physical and sexual intimate partner violence (IPV) and (ii) associations of development of complications around delivery and IPV. Methods We used data from the 2007 Bangladesh Demographic Health Survey. The analyses were based on the responses of 2001 currently married women having a ...
Aung Thi - - 2013
We report a series of 4 cases of transcatheter aortic valve replacement infective endocarditis from our institution. Atypical diagnostic features were noted echocardiographically. Infection with enterococcal species was prevalent and a coexisting mitral valve vegetation was found in 2 patients. All 4 patients had excellent responses to intravenous antibiotics.
Deezagi Abdolkhaleg - - 2013
During erythropoiesis, some organelles such as mitochondria and nucleus are lost by autophagy and enucleation processes in the presence of macrophages in vivo. In vitro production of erythrocytes has raised many questions about the mechanism of enucleation. The aim of this work was to study the DNA breakdown, enucleation, hemoglobin ...
Myachykov Andriy - - 2013
We analysed how syntactic flexibility influences sentence production in two different languages-English and Russian. In Experiment 1, speakers were instructed to produce as many structurally different descriptions of transitive-event pictures as possible. Consistent with the syntactically more flexible Russian grammar, Russian participants produced more descriptions and used a greater variety ...
Aung Ar Kar - - 2013
Pulmonary infections by Sporothrix spp. manifest radiologically as cavitary or non-cavitary disease depending on whether the infection is primary pulmonary or multifocal sporotrichosis. Despite current guidelines, the optimal management for pulmonary sporotrichosis remains unclear. In order to clarify this, we present two cases of pulmonary sporotrichosis, as well as the ...
Poutiainen Pekka Kalevi - - 2013
Luciferase reporter assays are commonly used in high-throughput screening methods. Here, we report new firefly luciferase (FLuc) inhibitors based on 5-benzyl-3-phenyl-4,5-dihydroisoxazoles and 5-benzyl-3-phenyl-1,4,2-dioxazoles, which showed up as "false positives" in a luciferase reporter gene-based assay for nuclear receptor antagonists. The inhibition was shown to be non-competitive for both natural enzyme ...
Kimmel Gary L - - 2013
The herbicide glyphosate has undergone multiple safety tests for developmental toxicity in rats and rabbits. The European Commission's 2002 review of available glyphosate data discusses specific heart defects observed in several individual rabbit developmental toxicity studies, but describes the evidence for a potential causal relationship as equivocal. The present assessment ...
Liu Guang Jian - - 2013
Abstract The purpose of this report is to inform medical professionals of a case in which brachiocephalic vein thrombosis caused a transient ischemic attack (TIA). A brain computerized tomography (CT) scan, magnetic resonance imaging (MRI), digital subtraction angiography (DSA), head and lung CT angiography (CTA), jugular venography, cardiac color Doppler ...
Shivashri C - - 2013
Acetaminophen (APAP)-induced liver damage is one of the most common problems among the population. Therefore, the study was aimed to investigate the hepatoprotective effect of celery leaves on APAP-induced toxicity in a freshwater fish, Pangasius sutchi. Fish were divided into four experimental groups of 6 fish each. Group 1 served ...
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