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Chen Haijun H Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, - - 2013
EPAC1 and EPAC2, two isoforms of exchange proteins directly activated by cAMP (EPAC), respond to the second messenger cAMP and regulate a wide variety of intracellular processes under physiological and pathophysiological circumstances. Herein, we report the chemical design, synthesis, and pharmacological characterization of three different scaffolds (diarylsulfones, N,N-diarylamines, and arylsulfonamides) ...
Hoffmann Jordan J Johns Hopkins University, Baltimore, Maryland, - - 2013
The effects of ion-ion and ion-wall correlations in nanochannels are explored, specifically how they influence voltage- and pressure-driven currents and pressure-to-voltage energy conversion. Cations of different diameters (0.15, 0.3, and 0.9 nm) and different valences (+1, +2, and +3) at concentrations ranging from 10(-6) M to 1 M are considered ...
Fraccalvieri Domenico D Department of Earth and Environmental Sciences, University of Milano-Bicocca, Milan, - - 2013
The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that mediates the biological and toxic effects of a wide variety of structurally diverse chemicals, including the toxic environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). While significant interspecies differences in AHR ligand binding specificity, selectivity, and response have been observed, the structural determinants ...
Ramachandran Srinivas S Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, - - 2013
The ability to predict RNA secondary structure is fundamental for understanding and manipulating RNA function. The information obtained from selective 2'-hydroxyl acylation analyzed by primer extension (SHAPE) experiments greatly improves the accuracy of RNA secondary structure prediction. Recently, Das and colleagues [Kladwang, W., et al. (2011) Biochemistry 50, 8049-8056] proposed ...
Bansal Nitin N Hauptman-Woodward Medical Research Institute, 700 Ellicott Street, Buffalo, NY 14203, - - 2013
The SLIP1-SLBP complex activates translation of replication-dependent histone mRNAs. In this report, we describe how the activity of the SLIP1-SLBP complex is modulated by phosphorylation and oligomerization. Biophysical characterization of the free proteins shows that whereas SLIP1 is a homodimer that does not bind RNA, human SLBP is an intrinsically ...
Yu Linda P C LP Department of Biological Sciences, Columbia University, New York, NY 10027, - - 2013
Biotin carboxylase (BC) is a conserved component among biotin-dependent carboxylases and catalyzes the MgATP-dependent carboxylation of biotin, using bicarbonate as the CO₂ donor. Studies with Escherichia coli BC have suggested long-range communication between the two active sites of a dimer, although its mechanism is not well understood. In addition, mutations ...
Ang Lawrence - - 2013
This study was undertaken to determine the roles of serum fibrinogen and residual platelet reactivity after clopidogrel pre-treatment on ischemic events after elective percutaneous coronary intervention (PCI). Both elevated serum fibrinogen and high platelet reactivity with thienopyridines are associated with ischemic cardiovascular events. Elevated fibrinogen also contributes to high on-clopidogrel ...
Elias Karla Maria Ibraim da Freiria - - 2013
OBJECTIVE: To verify the auditory selective attention in children with stroke. METHODS: Dichotic tests of binaural separation (non-verbal and consonant-vowel) and binaural integration - digits and Staggered Spondaic Words Test (SSW) - were applied in 13 children (7 boys), from 7 to 16 years, with unilateral stroke confirmed by neurological ...
Kubanek Milos - - 2013
This study aimed to evaluate the performance of cardiac magnetic resonance (CMR), cardiac biomarkers, and endomyocardial biopsy (EMB) results to predict left ventricular reverse remodeling (LVRR) in individuals with recent-onset dilated cardiomyopathy (DCM). LVRR is a marker of a favorable prognosis in individuals with recent-onset DCM. We used the aforementioned ...
Bianco André de Macedo - - 2013
A retrospective study of 81 patients with low-grade astrocytoma (LGA) comparing the efficacy of aggressive versus less aggressive surgery in eloquent and non-eloquent brain areas was conducted. Extent of surgical resection was analyzed to assess overall survival (OS) and progression- free survival (PFS). Degree of tumor resection was classified as ...
Safar Michel E - - 2013
Metabolic syndrome (MetS), an important component of insulin resistance and cardiovascular (CV) risk, is defined by 3 or more of the following characteristics: abdominal obesity, hyperglycemia, hypertension, hypertriglyceridemia, and hypo-high-density lipoprotein cholesterolemia. Based on the previously published age- and sex-mediated DESIR (Data from an Epidemiological Study on the Insulin Resistance ...
Gepp Ricardo de Amoreira - - 2013
Spinal cord tumors are a rare neoplasm of the central nervous system (CNS). The occurrence of metastases is related to poor prognosis. The authors analyzed one series of metastasis cases and their associated mortality. METHODS: Clinical characteristics were studied in six patients with intramedullary tumors with metastases in a series ...
Larsen Steen - - 2013
Glucose tolerance and skeletal muscle coenzyme Q(10) (Q(10)) content, mitochondrial density, and mitochondrial oxidative phosphorylation (OXPHOS) capacity were measured in simvastatin-treated patients (n = 10) and in well-matched control subjects (n = 9). A prevalent side effect of statin therapy is muscle pain, and yet the basic mechanism behind it ...
Nakano Miki - - 2013
Polyglutamine (polyQ, a peptide) with an abnormal repeat length is the causative agent of polyQ diseases, such as Huntington's disease. Although glutamine is a polar residue, polyQ peptides form insoluble aggregates in water, and the mechanism for this aggregation is still unclear. To elucidate the detailed mechanism for the nucleation ...
Pérez Joanne - - 2013
This study examined the effects of three widely used pesticides that have been previously detected in aquatic systems neighbouring agricultural fields on the early-life stages of the zebrafish Danio rerio. Tests involving single exposures and binary combinations of the s-triazine herbicides (atrazine and terbuthylazine) and the organophosphate insecticide chlorpyrifos were ...
Garrett-Sinha Lee Ann - - 2013
The Ets1 transcription factor is a member of the Ets gene family and is highly conserved throughout evolution. Ets1 is known to regulate a number of important biological processes in normal cells and in tumors. In particular, Ets1 has been associated with regulation of immune cell function and with an ...
Schönfeld C-L - - 2013
There are several methods for local and general anesthesia in ophthalmological surgery that attempt to provide a stress and pain-free operating environment for both patient and surgeon. The decision-making depends on medical as well as on ophthalmological criteria and jointly falls to ophthalmologists and anesthesiologists. Topical and injective anesthesia (with ...
Mohagheghi Fatemeh - - 2013
Inducers of mitochondrial biogenesis are widely under investigation for use in a novel therapeutic approach in neurodegenerative disorders. The ability of Gemfibrozil, a fibrate, is investigated for the first time to modulate mitochondrial pro-survival factors involved in the mitochondrial biogenesis signaling pathway, including peroxisome proliferator-activated receptor coactivator-1α (PGC-1α), nuclear respiratory ...
Manganelli Fiore - - 2013
Processing of time in the millisecond range seems to depend on cerebellar function and it can be assessed by using the somatosensory temporal discrimination threshold testing. No studies have yet investigated this temporal discrimination task in patients with cerebellar atrophy. Eleven patients with degenerative cerebellar ataxia and 11 controls underwent ...
Kim Young Seo - - 2013
Mesenchymal stromal cells (MSCs) are emerging as candidate cells for the treatment of neurological diseases because of their neural replacement, neuroprotective, and neurotrophic effects. However, the majority of MSCs transplanted by various routes fail to reach the site of injury, and they have demonstrated only minimal therapeutic benefit in clinical ...
Vranic Sandra - - 2013
Because of an increasing exposure to environmental and occupational nanoparticles (NPs), the potential risk of these materials for human health should be better assessed. Since one of the main routes of entry of NPs is via the lungs, it is of paramount importance to further characterize their impact on the ...
Sun Yingxin - - 2013
Highly stable salt functional groups consisting of lithium cation and aromatic anions (C( n )H( n )N(5-n )-Li) are studied for hydrogen storage using ab initio calculations, force field development, and grand canonical Monte Carlo simulations. Second-order Møller-Plesset perturbation theory with the resolution of identity approximation calculations are calibrated at ...
Gurbaxani Avinash - - 2013
The repertoire of treatment options available to allergists and immunologists is ever increasing and with this comes the increased potential for these treatments to cause adverse ocular side effects. Corticosteroids remain the first line of treatment for most immunological disorders and physicians should be alerted to their extensive ocular morbidity ...
Peter S - - 2013
A 10-year-old child presented after accidental exposure of the left eye to a blue hair dye containing methylene blue. Mild ocular surface changes and a selective blue staining of the usually invisible corneal nerve fibre bundles were present. Corneal sensitivity was reduced. Despite copious lubrication a transient neurotrophic keratitis developed ...
Kurkó Júlia - - 2013
The "Bermuda triangle" of genetics, environment and autoimmunity is involved in the pathogenesis of rheumatoid arthritis (RA). Various aspects of genetic contribution to the etiology, pathogenesis and outcome of RA are discussed in this review. The heritability of RA has been estimated to be about 60 %, while the contribution of ...
Molozzi Joseline - - 2013
The Reference Condition Approach (RCA) is now widely adopted as a basis for the evaluation of the ecological quality of water bodies. In accordance with the RCA, the integrity of communities found in a given location should be analyzed according to their deviation from the communities that would be expected ...
Strupp M - - 2013
The spectrum of diagnoses of patients with dizziness as the leading symptom who consult a neurologist does not differ greatly from the spectrum of those who consult ear nose and throat (ENT) specialists or general practitioners (GP). The most frequent forms are benign paroxysmal positioning vertigo (BPPV), phobic postural vertigo, ...
Devi Ningombam Linthoingambi - - 2013
Eighty-two surface soil samples were collected from forest, grassland, tea estate, wildlife sanctuary, wetland, and roadside areas from the northeastern states of India, viz., Tripura, Manipur, and Assam. Thirteen different organochlorine pesticides (OCPs) were detected from background soils using gas chromatography electron capture detector. Manipur soils were found to be ...
Politzer Peter - - 2013
A synchronous, concerted chemical process is rigorously divided by the reaction force F(R), the negative gradient of V(R), into "reactant" and "product" regions which are dominated by structural changes and an intervening "transition" region which is electronically intensive. The reaction force constant κ(R), the second derivative of V(R), is negative ...
Badar Bazigha - - 2013
Dal Lake, a cradle of Kashmiri civilization has strong linkage with socioeconomics of the state of Jammu and Kashmir. During last few decades, anthropogenic pressures in Dal Lake Catchment have caused environmental deterioration impairing, inter-alia, sustained biotic communities and water quality. The present research was an integrated impact analysis of ...
Willison J H Martin - - 2013
The Three Gorges Dam on the Yangtze River in China has created a major reservoir in which the water level fluctuates annually by about 30 m, generating a drawdown zone of up to 350 km(2) in summer. Since construction of the dam, there has been scientific and public interest in how to ...
Volkmann Jens - - 2013
Motor complications in Parkinson's disease (PD) result from the short half-life and irregular plasma fluctuations of oral levodopa. When strategies of providing more continuous dopaminergic stimulation by adjusting oral medication fail, patients may be candidates for one of three device-aided therapies: deep brain stimulation (DBS), continuous subcutaneous apomorphine infusion, or ...
Rahman Mosiur - - 2013
Objectives To estimate (i) lifetime prevalence of physical and sexual intimate partner violence (IPV) and (ii) associations of development of complications around delivery and IPV. Methods We used data from the 2007 Bangladesh Demographic Health Survey. The analyses were based on the responses of 2001 currently married women having a ...
Aung Thi - - 2013
We report a series of 4 cases of transcatheter aortic valve replacement infective endocarditis from our institution. Atypical diagnostic features were noted echocardiographically. Infection with enterococcal species was prevalent and a coexisting mitral valve vegetation was found in 2 patients. All 4 patients had excellent responses to intravenous antibiotics.
Deezagi Abdolkhaleg - - 2013
During erythropoiesis, some organelles such as mitochondria and nucleus are lost by autophagy and enucleation processes in the presence of macrophages in vivo. In vitro production of erythrocytes has raised many questions about the mechanism of enucleation. The aim of this work was to study the DNA breakdown, enucleation, hemoglobin ...
Myachykov Andriy - - 2013
We analysed how syntactic flexibility influences sentence production in two different languages-English and Russian. In Experiment 1, speakers were instructed to produce as many structurally different descriptions of transitive-event pictures as possible. Consistent with the syntactically more flexible Russian grammar, Russian participants produced more descriptions and used a greater variety ...
Aung Ar Kar - - 2013
Pulmonary infections by Sporothrix spp. manifest radiologically as cavitary or non-cavitary disease depending on whether the infection is primary pulmonary or multifocal sporotrichosis. Despite current guidelines, the optimal management for pulmonary sporotrichosis remains unclear. In order to clarify this, we present two cases of pulmonary sporotrichosis, as well as the ...
Khajetoorians Alexander Ako - - 2013
The future of nanoscale spin-based technologies hinges on a fundamental understanding and dynamic control of atomic-scale magnets. The role of the substrate conduction electrons on the dynamics of supported atomic magnets is still a question of interest lacking experimental insight. We characterized the temperature-dependent dynamical response of artificially constructed magnets, ...
Eastland Taryn Y - - 2013
African-American (AA) women could be instrumental in communicating positive prostate screening behavior to the significant males in their lives. However, little is known about AA women's prostate cancer attitudes, perceived behavioral control, subjective norms, intentions, behaviors, and knowledge regarding prostate cancer screening. This study describes the development and psychometric testing ...
Castro Joffre E - - 2013
A comprehensive environmental evaluation was completed on 20 metals: two reference metals (Fe, Al) and several minor trace metals (As, Ba, Co, Cr, Cu, Mn, Ni, Pb, V, and Zn) for surface soils and sediments collected from 50 sites in Everglades National Park (ENP), the coastal fringes of Biscayne National ...
King M - - 2013
BACKGROUND: PredictD is a risk algorithm that was developed to predict risk of onset of major depression over 12 months in general practice attendees in Europe and validated in a similar population in Chile. It was the first risk algorithm to be developed in the field of mental disorders. Our ...
Pawluk Shane A - - 2013
Malaria is one of the most common parasitic infections worldwide. Plasmodium falciparum is the most prevalent strain in Africa and also the most fatal. The disease especially affects children, with those under age 5 years accounting for approximately 86 % of malaria deaths in 2010. The objectives of this review are ...
Asgari M - - 2013
Employing a biharmonic boundary integral method with linear elements, coarsening dynamics of nanodroplets on topographical step heterogeneity is investigated. It is shown that the step height and droplet configuration have an influential effect on the dynamics. Increasing the step height slows down the process while locating the droplets close to ...
Michal Freedman D - - 2013
There are no observational studies or controlled trials of amyotrophic lateral sclerosis (ALS) and circulating α-tocopherol (vitamin E) for prevention of ALS. This study addresses that gap. The study population comprised 29,127 Finnish male smokers, aged 50-69 years, who participated in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study, which is ...
Pfister Ted - - 2013
Systematic review data demonstrate that 5% of ALS cases are familial (FALS). Causative superoxide dismutase-1 (SOD1) mutations are identified in 10-20% of FALS. Few reports of FALS epidemiology exist in Canada. We completed a retrospective review of all FALS cases within the province of Alberta between 2002 and 2011. Descriptive ...
Ferreira Victor S - - 2013
Speakers should be motivated to produce easy-to-understand sentences, but they must successfully say sentences that are harder to produce. Four experiments assessed how verb bias influences the mention of the optional "that" in sentence-complement structures. Without the "that", such sentences can be incorrectly interpreted as including direct objects (garden paths), ...
Petsche Steven J - - 2013
Examining the cross-section of the human cornea with second harmonic-generated (SHG) imaging shows that many lamellae do not lie parallel to the cornea's anterior surface but have inclined trajectories that take them through the corneal thickness with a depth-dependent distribution. A continuum mechanics-based model of stromal elasticity is developed based ...
Schüttrumpf Jan Philipp - - 2013
The blood supply to the proximal patella is provided primarily via intraosseous vessels from the inferior patella. Two vascular systems within the patella are distinguished: Tiny arteries penetrate the middle third of the anterior patellar surface via vascular foramina and continue in a proximal direction. Additional vessels enter the patella ...
Nirmalkar Jayant - - 2013
The effects of combustion of the fire crackers on the air quality in eastern Central India were studied for the first time during Diwali festival. This case study analyzes the size distribution and temporal variation of aerosols collected in the rural area of eastern Central India during pre-diwali, Diwali and ...
Kamino Shinichiro - - 2013
We have designed and synthesized a new class of rhodamine dyes with an extended π-conjugated system and named them 3',3''-bis(oxospiroisobenzofuran)-3,7-bis(diethylamino)benzopyrano-xanthene (ABPX01) dyes. ABPX01 exhibits fluorescence emission in both dilute solution and the aggregate state, whereas conventional rhodamine dyes show aggregation-induced quenching (AIQ). The chemical species of ABPX01 in solution were ...
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