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Tubbs Jason D JD Department of Chemistry, University of Rochester, Rochester, NY 14627, - - 2013
The sequence dependence of RNA energetics is important for predicting RNA structure. Hairpins with C(n) loops are consistently less stable than hairpins with other loops, which suggests the structure of C(n) regions could be unusual in the "unfolded" state. For example, previous nuclear magnetic resonance (NMR) evidence suggested that polycytidylic ...
Thiagarajan Giridhar G Department of Bioengineering, University of Utah , Salt Lake City, Utah 84112, - - 2013
Development of carrier systems to improve oral bioavailability and target drugs to specific sites continues to be an unmet need. The goal of this study was to evaluate the potential of anionic generation (G) 6.5 poly(amido amine) (PAMAM) dendrimers in oral drug delivery by assessing their in vivo oral translocation. ...
Kumar T Santhosh TS Molecular Recognition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, Maryland 20892, - - 2013
Activation of a cardiac myocyte P2X4 receptor protects against heart failure. 5'-Phosphonate and 5'-phosphate analogues of AMP containing a (N)-methanocarba (bicyclo[3.1.0]hexane) system could protect from heart failure by potentially activating this cardioprotective channel. Phosphoesters and phosphonodiesters were synthesized and administered in vivo via a miniosmotic pump in a mouse ischemic ...
Hou Guangjin G Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, - - 2013
The proton chemical shift (CS) tensor is a sensitive probe of structure and hydrogen bonding. Highly accurate quantum-chemical protocols exist for computation of (1)H magnetic shieldings in the various contexts, making proton chemical shifts potentially a powerful predictor of structural and electronic properties. However, (1)H CS tensors are not yet ...
Chen Haijun H Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, - - 2013
EPAC1 and EPAC2, two isoforms of exchange proteins directly activated by cAMP (EPAC), respond to the second messenger cAMP and regulate a wide variety of intracellular processes under physiological and pathophysiological circumstances. Herein, we report the chemical design, synthesis, and pharmacological characterization of three different scaffolds (diarylsulfones, N,N-diarylamines, and arylsulfonamides) ...
Hoffmann Jordan J Johns Hopkins University, Baltimore, Maryland, - - 2013
The effects of ion-ion and ion-wall correlations in nanochannels are explored, specifically how they influence voltage- and pressure-driven currents and pressure-to-voltage energy conversion. Cations of different diameters (0.15, 0.3, and 0.9 nm) and different valences (+1, +2, and +3) at concentrations ranging from 10(-6) M to 1 M are considered ...
Fraccalvieri Domenico D Department of Earth and Environmental Sciences, University of Milano-Bicocca, Milan, - - 2013
The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that mediates the biological and toxic effects of a wide variety of structurally diverse chemicals, including the toxic environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). While significant interspecies differences in AHR ligand binding specificity, selectivity, and response have been observed, the structural determinants ...
Ramachandran Srinivas S Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, - - 2013
The ability to predict RNA secondary structure is fundamental for understanding and manipulating RNA function. The information obtained from selective 2'-hydroxyl acylation analyzed by primer extension (SHAPE) experiments greatly improves the accuracy of RNA secondary structure prediction. Recently, Das and colleagues [Kladwang, W., et al. (2011) Biochemistry 50, 8049-8056] proposed ...
Bansal Nitin N Hauptman-Woodward Medical Research Institute, 700 Ellicott Street, Buffalo, NY 14203, - - 2013
The SLIP1-SLBP complex activates translation of replication-dependent histone mRNAs. In this report, we describe how the activity of the SLIP1-SLBP complex is modulated by phosphorylation and oligomerization. Biophysical characterization of the free proteins shows that whereas SLIP1 is a homodimer that does not bind RNA, human SLBP is an intrinsically ...
Yu Linda P C LP Department of Biological Sciences, Columbia University, New York, NY 10027, - - 2013
Biotin carboxylase (BC) is a conserved component among biotin-dependent carboxylases and catalyzes the MgATP-dependent carboxylation of biotin, using bicarbonate as the CO₂ donor. Studies with Escherichia coli BC have suggested long-range communication between the two active sites of a dimer, although its mechanism is not well understood. In addition, mutations ...
Ang Lawrence - - 2013
This study was undertaken to determine the roles of serum fibrinogen and residual platelet reactivity after clopidogrel pre-treatment on ischemic events after elective percutaneous coronary intervention (PCI). Both elevated serum fibrinogen and high platelet reactivity with thienopyridines are associated with ischemic cardiovascular events. Elevated fibrinogen also contributes to high on-clopidogrel ...
Gepp Ricardo de Amoreira - - 2013
Spinal cord tumors are a rare neoplasm of the central nervous system (CNS). The occurrence of metastases is related to poor prognosis. The authors analyzed one series of metastasis cases and their associated mortality. METHODS: Clinical characteristics were studied in six patients with intramedullary tumors with metastases in a series ...
Kubanek Milos - - 2013
This study aimed to evaluate the performance of cardiac magnetic resonance (CMR), cardiac biomarkers, and endomyocardial biopsy (EMB) results to predict left ventricular reverse remodeling (LVRR) in individuals with recent-onset dilated cardiomyopathy (DCM). LVRR is a marker of a favorable prognosis in individuals with recent-onset DCM. We used the aforementioned ...
Safar Michel E - - 2013
Metabolic syndrome (MetS), an important component of insulin resistance and cardiovascular (CV) risk, is defined by 3 or more of the following characteristics: abdominal obesity, hyperglycemia, hypertension, hypertriglyceridemia, and hypo-high-density lipoprotein cholesterolemia. Based on the previously published age- and sex-mediated DESIR (Data from an Epidemiological Study on the Insulin Resistance ...
Bianco André de Macedo - - 2013
A retrospective study of 81 patients with low-grade astrocytoma (LGA) comparing the efficacy of aggressive versus less aggressive surgery in eloquent and non-eloquent brain areas was conducted. Extent of surgical resection was analyzed to assess overall survival (OS) and progression- free survival (PFS). Degree of tumor resection was classified as ...
Larsen Steen - - 2013
Glucose tolerance and skeletal muscle coenzyme Q(10) (Q(10)) content, mitochondrial density, and mitochondrial oxidative phosphorylation (OXPHOS) capacity were measured in simvastatin-treated patients (n = 10) and in well-matched control subjects (n = 9). A prevalent side effect of statin therapy is muscle pain, and yet the basic mechanism behind it ...
Elias Karla Maria Ibraim da Freiria - - 2013
OBJECTIVE: To verify the auditory selective attention in children with stroke. METHODS: Dichotic tests of binaural separation (non-verbal and consonant-vowel) and binaural integration - digits and Staggered Spondaic Words Test (SSW) - were applied in 13 children (7 boys), from 7 to 16 years, with unilateral stroke confirmed by neurological ...
Schönfeld C-L - - 2013
There are several methods for local and general anesthesia in ophthalmological surgery that attempt to provide a stress and pain-free operating environment for both patient and surgeon. The decision-making depends on medical as well as on ophthalmological criteria and jointly falls to ophthalmologists and anesthesiologists. Topical and injective anesthesia (with ...
Garrett-Sinha Lee Ann LA Department of Biochemistry, State University of New York at Buffalo, Center of Excellence in Bioinformatics and Life Sciences, Room B3-306, 701 Ellicott Street, Buffalo, NY 14203, USA. - - 2013
The Ets1 transcription factor is a member of the Ets gene family and is highly conserved throughout evolution. Ets1 is known to regulate a number of important biological processes in normal cells and in tumors. In particular, Ets1 has been associated with regulation of immune cell function and with an ...
Kim Young Seo - - 2013
Mesenchymal stromal cells (MSCs) are emerging as candidate cells for the treatment of neurological diseases because of their neural replacement, neuroprotective, and neurotrophic effects. However, the majority of MSCs transplanted by various routes fail to reach the site of injury, and they have demonstrated only minimal therapeutic benefit in clinical ...
Strupp M - - 2013
The spectrum of diagnoses of patients with dizziness as the leading symptom who consult a neurologist does not differ greatly from the spectrum of those who consult ear nose and throat (ENT) specialists or general practitioners (GP). The most frequent forms are benign paroxysmal positioning vertigo (BPPV), phobic postural vertigo, ...
Devi Ningombam Linthoingambi - - 2013
Eighty-two surface soil samples were collected from forest, grassland, tea estate, wildlife sanctuary, wetland, and roadside areas from the northeastern states of India, viz., Tripura, Manipur, and Assam. Thirteen different organochlorine pesticides (OCPs) were detected from background soils using gas chromatography electron capture detector. Manipur soils were found to be ...
Manganelli Fiore - - 2013
Processing of time in the millisecond range seems to depend on cerebellar function and it can be assessed by using the somatosensory temporal discrimination threshold testing. No studies have yet investigated this temporal discrimination task in patients with cerebellar atrophy. Eleven patients with degenerative cerebellar ataxia and 11 controls underwent ...
Volkmann Jens - - 2013
Motor complications in Parkinson's disease (PD) result from the short half-life and irregular plasma fluctuations of oral levodopa. When strategies of providing more continuous dopaminergic stimulation by adjusting oral medication fail, patients may be candidates for one of three device-aided therapies: deep brain stimulation (DBS), continuous subcutaneous apomorphine infusion, or ...
Badar Bazigha - - 2013
Dal Lake, a cradle of Kashmiri civilization has strong linkage with socioeconomics of the state of Jammu and Kashmir. During last few decades, anthropogenic pressures in Dal Lake Catchment have caused environmental deterioration impairing, inter-alia, sustained biotic communities and water quality. The present research was an integrated impact analysis of ...
Sun Yingxin - - 2013
Highly stable salt functional groups consisting of lithium cation and aromatic anions (C( n )H( n )N(5-n )-Li) are studied for hydrogen storage using ab initio calculations, force field development, and grand canonical Monte Carlo simulations. Second-order Møller-Plesset perturbation theory with the resolution of identity approximation calculations are calibrated at ...
Mohagheghi Fatemeh - - 2013
Inducers of mitochondrial biogenesis are widely under investigation for use in a novel therapeutic approach in neurodegenerative disorders. The ability of Gemfibrozil, a fibrate, is investigated for the first time to modulate mitochondrial pro-survival factors involved in the mitochondrial biogenesis signaling pathway, including peroxisome proliferator-activated receptor coactivator-1α (PGC-1α), nuclear respiratory ...
Peter S - - 2013
A 10-year-old child presented after accidental exposure of the left eye to a blue hair dye containing methylene blue. Mild ocular surface changes and a selective blue staining of the usually invisible corneal nerve fibre bundles were present. Corneal sensitivity was reduced. Despite copious lubrication a transient neurotrophic keratitis developed ...
Kurkó Júlia - - 2013
The "Bermuda triangle" of genetics, environment and autoimmunity is involved in the pathogenesis of rheumatoid arthritis (RA). Various aspects of genetic contribution to the etiology, pathogenesis and outcome of RA are discussed in this review. The heritability of RA has been estimated to be about 60 %, while the contribution of ...
Vranic Sandra - - 2013
Because of an increasing exposure to environmental and occupational nanoparticles (NPs), the potential risk of these materials for human health should be better assessed. Since one of the main routes of entry of NPs is via the lungs, it is of paramount importance to further characterize their impact on the ...
Willison J H Martin - - 2013
The Three Gorges Dam on the Yangtze River in China has created a major reservoir in which the water level fluctuates annually by about 30 m, generating a drawdown zone of up to 350 km(2) in summer. Since construction of the dam, there has been scientific and public interest in how to ...
Gurbaxani Avinash - - 2013
The repertoire of treatment options available to allergists and immunologists is ever increasing and with this comes the increased potential for these treatments to cause adverse ocular side effects. Corticosteroids remain the first line of treatment for most immunological disorders and physicians should be alerted to their extensive ocular morbidity ...
Politzer Peter - - 2013
A synchronous, concerted chemical process is rigorously divided by the reaction force F(R), the negative gradient of V(R), into "reactant" and "product" regions which are dominated by structural changes and an intervening "transition" region which is electronically intensive. The reaction force constant κ(R), the second derivative of V(R), is negative ...
Nakano Miki - - 2013
Polyglutamine (polyQ, a peptide) with an abnormal repeat length is the causative agent of polyQ diseases, such as Huntington's disease. Although glutamine is a polar residue, polyQ peptides form insoluble aggregates in water, and the mechanism for this aggregation is still unclear. To elucidate the detailed mechanism for the nucleation ...
Pérez Joanne - - 2013
This study examined the effects of three widely used pesticides that have been previously detected in aquatic systems neighbouring agricultural fields on the early-life stages of the zebrafish Danio rerio. Tests involving single exposures and binary combinations of the s-triazine herbicides (atrazine and terbuthylazine) and the organophosphate insecticide chlorpyrifos were ...
Molozzi Joseline - - 2013
The Reference Condition Approach (RCA) is now widely adopted as a basis for the evaluation of the ecological quality of water bodies. In accordance with the RCA, the integrity of communities found in a given location should be analyzed according to their deviation from the communities that would be expected ...
He Haiyan - - 2013
Two novel β-glucosidases (BGHG1 and BGHG2) were purified from the enzyme extract of Aspergillus oryzae HML366 through nondenaturing gel electrophoresis and anion-exchange chromatography. The molecular weights for BGHG1 and BGHG2 were 93 and 138 kDa, respectively. The amino acid sequences were determined by matrix-assisted laser desorption/ionization tandem time of flight. The ...
Wang Rong - - 2013
Theoretical understanding of the surface modification of Cl-passivated silicon nanocrystals (Si NCs) is rather limited, in stark contrast to that for H-passivated Si NCs. We now investigate four surface-modification schemes (silanization, alkylation, alkoxylation and aminization) that have been experimentally adopted for Cl-passivated Si NCs in the framework of density functional ...
Seubert Erica L - - 2013
Reports of toxic harmful algal blooms (HABs) attributed to the diatom Pseudo-nitzschia spp. have been increasing in California during the last several decades. Whether this increase can be attributed to enhanced awareness and monitoring or to a dramatic upswing in the development of HAB events remains unresolved. Given these uncertainties, ...
Timratana P - - 2013
BACKGROUND: Gastric electrical stimulator (GES) implantation is effective in certain patients with gastroparesis; however, laparotomy is often employed for placement. The aim of this study is to review outcomes of patients who underwent laparoscopic GES therapy for diabetic and idiopathic gastroparesis at a large referral center. METHODS: Patients who underwent ...
Manoukian A - - 2013
Volatile organic compounds (VOCs) and particles emitted by incense sticks and candles combustion in an experimental room have been monitored on-line and continuously with a high time resolution using a state-of-the-art high sensitivity-proton transfer reaction-mass spectrometer (HS-PTR-MS) and a condensation particle counter (CPC), respectively. The VOC concentration-time profiles, i.e., an ...
Feng Shi - - 2013
Mind wandering is a phenomenon in which attention drifts away from the primary task to task-unrelated thoughts. Previous studies have used self-report methods to measure the frequency of mind wandering and its effects on task performance. Many of these studies have investigated mind wandering in simple perceptual and memory tasks, ...
Shehata Awad A - - 2013
Infectious laryngotracheitis virus (ILTV) continues to cause respiratory disease in Egypt in spite of vaccination. The currently available modified live ILTV vaccines provide good protection but may also induce latent infections and even clinical disease if they spread extensively from bird-to-bird in the field. Four field ILTV isolates, designated ILT-Behera2007, ...
McNally Lr L James Graham Brown Cancer Center , University of Louisville, Louisville , - - 2013
During the development, progression and dissemination of neoplastic lesions, cancer cells hijack normal pathways and mechanisms, especially those involved in repair and embryologic development. These pathways include those involved in intercellular communication, control of transcription, post-transcriptional regulation of protein production including translation of mRNAs, post-translational protein modifications, e.g., acetylation of ...
Pfister Ted - - 2013
Systematic review data demonstrate that 5% of ALS cases are familial (FALS). Causative superoxide dismutase-1 (SOD1) mutations are identified in 10-20% of FALS. Few reports of FALS epidemiology exist in Canada. We completed a retrospective review of all FALS cases within the province of Alberta between 2002 and 2011. Descriptive ...
Ferreira Victor S VS Department of Psychology and Center for Research in Language, University of California, San Diego, La Jolla, CA, 92093-0109, USA. - - 2013
Speakers should be motivated to produce easy-to-understand sentences, but they must successfully say sentences that are harder to produce. Four experiments assessed how verb bias influences the mention of the optional "that" in sentence-complement structures. Without the "that", such sentences can be incorrectly interpreted as including direct objects (garden paths), ...
Petsche Steven J - - 2013
Examining the cross-section of the human cornea with second harmonic-generated (SHG) imaging shows that many lamellae do not lie parallel to the cornea's anterior surface but have inclined trajectories that take them through the corneal thickness with a depth-dependent distribution. A continuum mechanics-based model of stromal elasticity is developed based ...
Schüttrumpf Jan Philipp - - 2013
The blood supply to the proximal patella is provided primarily via intraosseous vessels from the inferior patella. Two vascular systems within the patella are distinguished: Tiny arteries penetrate the middle third of the anterior patellar surface via vascular foramina and continue in a proximal direction. Additional vessels enter the patella ...
Nirmalkar Jayant - - 2013
The effects of combustion of the fire crackers on the air quality in eastern Central India were studied for the first time during Diwali festival. This case study analyzes the size distribution and temporal variation of aerosols collected in the rural area of eastern Central India during pre-diwali, Diwali and ...
Vreugdenburg Thomas D - - 2013
The objective of this study aimed to systematically identify and evaluate all the available evidence of safety, effectiveness and diagnostic accuracy for three emerging classes of technology promoted for breast cancer screening and diagnosis: Digital infrared thermal imaging (DITI), electrical impedance scanning (EIS) and elastography. A systematic search of seven ...
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