Search Results
Results 801 - 850 of 2749
< 12 13 14 15 16 17 18 19 20 21 22 >
Ellis Terry - - 2013
Exercise is known to reduce disability and improve quality of life in people with Parkinson disease (PD). Although barriers to exercise have been studied in older adults, barriers in people with chronic progressive neurological diseases, such as PD, are not well defined. The purpose of this study was to identify ...
Kaluza David - - 2013
OBJECTIVE: Histone deacetylases (HDACs) modulate gene expression by deacetylation of histone and nonhistone proteins. Several HDACs control angiogenesis, but the role of HDAC9 is unclear. METHODS AND RESULTS: Here, we analyzed the function of HDAC9 in angiogenesis and its involvement in regulating microRNAs. In vitro, silencing of HDAC9 reduces endothelial ...
Uehara Takeki T Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC, - - 2013
Hepatocellular carcinoma (HCC) mostly develops in patients with advanced fibrosis; however, the mechanisms of interaction between a genotoxic insult and fibrogenesis are not well understood. This study tested a hypothesis that fibrosis promotes HCC via a mechanism that involves activation of liver stem cells. First, B6C3F1 mice were administered diethylnitrosamine ...
Sucic Sonja - - 2013
The serotonin transporter (SERT) maintains serotonergic neurotransmission via rapid reuptake of serotonin from the synaptic cleft. SERT relies exclusively on the coat protein complex II component SEC24C for endoplasmic reticulum (ER) export. The closely related transporters for noradrenaline and dopamine depend on SEC24D. Here, we show that discrimination between SEC24C ...
Kambhampati Suman - - 2013
2-Methoxyestradiol (2-ME2) is an endogenous metabolite of estradiol. Previous studies demonstrated that 2-ME2 is a potent antiproliferative, pro-apoptotic, antiangiogenic drug and exogenous 2-ME2 is effective against different types of tumors. Unfortunately, only low systemic concentrations of 2-ME2 can be achieved following oral administration, even after very high doses are administered ...
van der Zee Marten - - 2013
Endometrioid endometrial cancer arises through a gradual series of histological changes, each accompanied by specific alterations in gene expression and activity. Activation of the Wnt/β-catenin pathway and loss of PTEN activity are frequently observed in endometrial cancers. However, the specific roles played by alterations in these pathways in the initiation ...
Gheonea Dan Ionut - - 2013
ABSTRACT: BACKGROUND: Second-generation intravenous blood-pool ultrasound contrast agents are increasingly used in endoscopic ultrasound (EUS) for characterization of microvascularization, differential diagnosis of benign and malignant focal lesions, as well as improved staging and guidance of therapeutic procedures. METHODS: The aim of our study was to prospectively compare the vascularisation patterns ...
Wettstein Guillaume - - 2013
Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by myofibroblast proliferation. Transition of epithelial/mesothelial cells into myofibroblasts [epithelial-to-mesenchymal transition (EMT)] occurs under the influence of transforming growth factor (TGF)-β1, with Snail being a major transcription factor. We study here the role of the heat-shock protein HSP27 in fibrogenesis and ...
Liu Wen-Hsin - - 2013
This study investigated TNF-α-mediated death pathway contribution to hydroquinone (HQ) cytotoxicity in human leukemia U937 cells. HQ-induced apoptosis of human leukemia U937 cells was characterized by the increase in mitochondrial membrane depolarization, procaspase-8 degradation and tBid production. Down-regulation of FADD blocked HQ-induced procaspase-8 degradation and rescued the viability of HQ-treated ...
Kaitu'u-Lino Tu'uhevaha J TJ Translational Obstetrics Group, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, 163 Studley Road, Heidelberg 3084, Victoria, - - 2013
Abnormal trophoblast growth can cause life-threatening disorders such as ectopic pregnancy, choriocarcinoma, and placenta accreta. EnGeneIC Delivery Vehicles (EDVs) are nanocells that can promote tissue-specific delivery of drugs and may be useful to medically treat such disorders. The objective of this study was to determine whether EDVs loaded with the ...
Woodburn J - - 2013
Objective: To investigate Achilles tendon (AT) biomechanics in psoriatic arthritis (PsA) patients with ultrasound confirmed features of enthesitis. Method: PsA patients and healthy control subjects underwent three-dimensional (3D) gait analysis to measure walking speed, rotational joint motion and the moments, power, and AT force at the ankle-subtalar joint complex. The ...
Otter Jonathan A - - 2013
OBJECTIVES: The increasing use of chlorhexidine for methicillin-resistant Staphylococcus aureus (MRSA) decolonization raises concerns about reduced susceptibility. We evaluated the carriage of chlorhexidine resistance genes and chlorhexidine susceptibility in MRSA before and after introduction of an institutional MRSA control programme incorporating chlorhexidine-based decolonization in 2004. METHODS: MRSA bloodstream infection (BSI) ...
Al-Daghri Nasser M - - 2013
ABSTRACT: BACKGROUND: Bronchial asthma is one of the most prevalent diseases in Arab children. Environmental pollution has been suggested to be considered causative of asthma, nasal symptoms and bronchitis in both children and adult. The objectives of this study were to evaluate the association between serum polycyclic aromatic hydrocarbons (PAHs) ...
Dovey Oliver M OM Department of Biochemistry, University of Leicester, Leicester, - - 2013
Histone deacetylase 1 and 2 (HDAC1/2) regulate chromatin structure as the catalytic core of the Sin3A, NuRD and CoREST co-repressor complexes. To better understand the key pathways regulated by HDAC1/2 in the adaptive immune system and inform their exploitation as drug targets, we have generated mice with a T-cell specific ...
Martinez Del Pero Marcos - - 2013
OBJECTIVES/HYPOTHESIS: Accurate assessment of disease activity in patients with otorhinolaryngological manifestations of granulomatosis with polyangiitis (Wegener's) (ENT/GPA) is necessary for treatment decisions and clinical trials. We have designed a disease activity score (ENT/GPA DAS) for this purpose. STUDY DESIGN: A prospective cross-sectional study. METHODS: GPA patients seen in a tertiary ...
Kangas Brian D BD Preclinical Pharmacology Laboratory, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA. - - 2013
Cannabinoid receptor 1 (CB(1)) inverse agonists (e.g., rimonabant) have been reported to produce adverse effects including nausea, emesis, and anhedonia that limit their clinical applications. Recent laboratory studies suggest that the effects of CB(1) neutral antagonists differ from those of such inverse agonists, raising the possibility of improved clinical utility. ...
Stout Gerdine J - - 2013
Xeroderma pigmentosum (XP), a UV sensitivity syndrome characterized by skin hyperpigmentation, premature aging and increased skin cancer, is caused by defects in the nucleotide excision repair (NER) pathway. XP shares phenotypical characteristics with telomere-associated diseases like Dyskeratosis congenita and mouse models with dysfunctional telomeres, including mice deficient for telomerase (Terc-/- ...
Ogba Ofonime M - - 2013
BACKGROUND: Most HIV-seropositive people who develop AIDS die from an opportunistic infection, such as pulmonary mycosis, rather than the HIV infection itself. Data on the pattern of respiratory mycoses and the immunological profile of HIV-seropositive patients in Nigeria are scarce and uncoordinated, so we investigated respiratory mycosis and CD4 count ...
Czopek Anna - - 2013
A computer aided ligand design study of imidazolidine-2,4-dione derivatives was conducted in order to obtain compounds with dual 5-HT(1A) receptor and serotonin transporter (SERT) affinity. According to molecular modeling results, series of Mannich bases were chosen and synthesized. Investigated compounds were tested for 5-HT(1A) , 5-HT(2A) , α(1) and SERT ...
Burdick Sanchez Nicole C - - 2013
A study was conducted to determine the effect of feeding yeast cell wall (YCW) products on the physiological and acute phase responses of crossbred, newly-received feedlot heifers to an endotoxin challenge. Heifers (n = 24; 219 ± 2.4 kg) were separated into treatment groups receiving either a control diet (n ...
Löhr Iren Høyland - - 2013
OBJECTIVES: To investigate the duration of faecal carriage of CTX-M-15-producing Klebsiella pneumoniae in infants colonized during a nosocomial neonatal intensive care unit (NICU) outbreak after discharge from hospital, possible risk factors for long-term colonization and transmission to household contacts (HCs). METHODS: Fifty-one infants colonized with two unrelated clones of CTX-M-15 ...
Randles Edward Graham - - 2013
Liposomes offer a method to encapsulate high concentrations of a drug, protecting the therapeutic upon in vivo administration. With an appropriate mechanism to manipulate lipid bilayer permeability, liposomes have the potential to deliver encapsulated drugs in a spatially and temporally controlled manner. In this investigation the photosensitizer aluminum phthalocyanine disulfonic ...
Jacobs Gerald H - - 2013
All mammalian cone photopigments are derived from the operation of representatives from two opsin gene families (SWS1 and LWS in marsupial and eutherian mammals; SWS2 and LWS in monotremes), a process that produces cone pigments with respective peak sensitivities in the short and middle-to-long wavelengths. With the exception of a ...
Barlow Axel - - 2013
Evidence from numerous Pan-African savannah mammals indicates that open-habitat refugia existed in Africa during the Pleistocene, isolated by expanding tropical forests during warm and humid interglacial periods. However, comparative data from other taxonomic groups are currently lacking. We present a phylogeographic investigation of the African puff adder (Bitis arietans), a ...
Liu Jing J Red Cell Physiology Laboratory, New York Blood Center, New York, NY, - - 2013
Terminal erythroid differentiation is the process during which proerythroblasts differentiate to produce enucleated reticulocytes. Although it is well established that during murine erythropoiesis in vivo, 1 proerythroblast undergoes 3 mitosis to generate sequentially 2 basophilic, 4 polychromatic, and 8 orthochromatic erythroblasts, currently there is no method to quantitatively monitor this ...
Postiaux Guy - - 2013
Acute viral bronchiolitis (AVB) is the most common disorder and the leading cause of respiratory failure in infants (<24 months of age). Respiratory syncytial virus is the most common pathogen (85%), but other organisms produce a similar clinical picture.(1) The disease can be graded as severe, moderate or mild and, ...
Ellwanger Kornelia - - 2013
The cellular functions of the serine/threonine protein kinase D (PKD) have been extensively studied within the last decade and distinct roles such as fission of vesicles at the Golgi compartment, coordination of cell migration and invasion, and regulation of gene transcription have been correlated with this kinase family. Here, we ...
Chalmers David - - 2013
Purpose: Venous thromboembolism (VTE) is a major complication of urologic surgery. Data is limited regarding the benefits of heparin prophylaxis for patients undergoing minimally invasive urologic surgery. The AUA recommends sequential compression devices (SCDs) for urologic laparoscopic and robotically assisted procedures but provides no clear recommendations for the use of ...
Jubri Zakiah - - 2013
ABSTRACT: BACKGROUND: Cigarette smoke contains free radicals and an have adverse effect to the immune system. Supplementation of palm oil vitamin E (palmvitee), is known has antioxidant properties is thought to be beneficial for system immune protection against free radicals activity. The objective of the study was to determine the ...
Prosser Gareth A - - 2013
D-cycloserine (DCS) is an antibiotic currently used in the second-line treatment of tuberculosis. DCS is a structural analogue of D-alanine and targets two enzymes involved in the cytosolic stages of peptidoglycan synthesis, alanine racemase (Alr) and D-alanine:D-alanine ligase (Ddl). The mechanisms of inhibition of DCS have been well assessed with ...
Renaud Stéphane S Department of Thoracic Surgery, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg, - - 2013
A best evidence topic was constructed according to a structured protocol. The question addressed was whether radical mediastinal lymphadenectomy should be performed during lung metastasectomy of renal cell carcinoma (RCC). Of the 13 papers found through a report search, seven represent the best evidence to answer this clinical question. The ...
Ahmad Aftab - - 2013
Hemichorea, due to contralateral basal ganglia dysfunction, is well described in patients with hyperglycaemia but the underlying mechanism remains poorly understood. We present clinical and radiological data that support ipsilateral vascular compromise to the basal ganglia in such cases. We suggest vascular evaluation in patients with unilateral neurological phenomena secondary ...
Coughlin Steven S - - 2013
The causal and noncausal associations that account for linkages between depressive symptoms and human immunodeficiency virus (HIV)/acquired immune deficiency syndrome are complex and not completely understood. Depression is a common mental health condition that affects approximately 20%-30% of persons receiving HIV medical care. Those suffering from depressive symptoms may be ...
Kim Sung Eun - - 2013
The aim of this study was to improve osteoblast function by delivering two growth factors, PDGF-BB and BMP-2, incorporated onto heparinized titanium (Hep-Ti) substrate. To achieve co-delivery of PDGF-BB and BMP-2, the surface of anodized Ti was immobilized with heparin, and then the two growth factors were coated onto the ...
Yousem Samuel A - - 2013
ABSTRACT BACKGROUND: Pulmonary Langerhans cell histiocytosis is a localized proliferation of Langerhans cells in the lung presenting without systemic manifestations, as bilateral nodular lung disease in adult cigarette smokers. The molecular basis for this proliferation is unknown. METHODS: Concurrent nodules in five patients (22 total) were microdissected from formalin fixed ...
Borówko MaƂgorzata - - 2013
We investigate the structure and adsorption of amphiphilic molecules at planar walls modified by tethered chain molecules using density functional theory. The molecules are modeled as spheres composed of a hydrophilic and hydrophobic part. The pinned chains are treated as tangentially jointed spheres that can interact with fluid molecules via ...
Ernst Andreas A Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario, - - 2013
The ubiquitin system regulates virtually all aspects of cellular function. We report a method to target the myriad enzymes that govern ubiquitination of protein substrates. We used massively diverse combinatorial libraries of ubiquitin variants to develop inhibitors of four deubiquitinases (DUBs) and analyzed the DUB-inhibitor complexes with crystallography. We extended ...
Gupta Sanjay - - 2013
The study was undertaken to assess the utility of cervico-vaginal/vault cytology in the follow-up of women treated for cervical cancer and benign gynecological conditions. Records of 3,523 cervico-vaginal smears from 2,658 women who underwent hysterectomy and/or radiotherapy or chemotherapy, over a 10-year period were retrieved. Data was collected on type ...
Sahu Kalyanasis - - 2013
Measurements of biexciton decays in semiconductor nanoparticles are easily contaminated by contributions from photoproducts or higher excitons. Theoretical work has shown that multiple population-period transient spectroscopy (MUPPETS) can measure biexciton decays free from these interferences. In this communication, the biexciton decay of CdSe/ZnS core-shell nanoparticles is measured with MUPPETS. The ...
Wackowski Olivia A OA Center for Tobacco Surveillance & Evaluation Research, University of Medicine & Dentistry of NJ-School of Public Health, New Brunswick, NJ, USA. - - 2013
Research attention on smokeless tobacco (SLT) has focused on SLT use, health risks, harm-reduction potential, and risk perceptions, but few studies have examined mediated communications about SLT. This study aims to contribute to the literature by providing the first description of SLT coverage in the news, an important communication channel ...
Sharan Roded R Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv, Israel. - - 2013
Since the first emergence of protein-protein interaction networks more than a decade ago, they have been viewed as static scaffolds of the signaling-regulatory events taking place in cells, and their analysis has been mainly confined to topological aspects. Recently, functional models of these networks have been suggested, ranging from Boolean ...
Ye Qiqi Q Department of Physiology, University of Toledo College of Medicine, Toledo Ohio 43614, - - 2013
The α1 Na/K-ATPase possesses both pumping and signaling functions. Using purified enzyme we found that the α1 Na/K-ATPase might interact with and regulate Src activity in a conformation-dependent manner. Here we further explored the importance of the conformational transition capability of α1 Na/K-ATPase in regulation of Src-related signal transduction in ...
Jónsdóttir Thórunn - - 2013
Objective. To investigate the long-term clinical, histological and serological affects of B-cell-depleting therapy (BCDT) in patients with LN refractory to conventional treatment.Methods. Twenty-five patients, followed for a mean time of 36 months (9-95 months), were included. Renal disease activity was evaluated with the BILAG index and renal response was determined ...
Chen Ming-Chung - - 2013
The aim of this study was to investigate the effect of gold nanoparticle (Au NP)-induced surface plasmons on the performance of organic photovoltaics (OPVs) that consist of copper phthalocyanine and fullerene as the active materials. The photon absorption can be enhanced by immobilization of surfactant-stabilized Au NPs on a self-assembled ...
Macklai Nejma S - - 2013
ABSTRACT: BACKGROUND: Among the many definitions of frailty, the frailty phenotype defined by Fried et al. is one of few constructs that has been repeatedly validated: first in the Cardiovascular Health Study (CHS) and subsequently in other large cohorts in the North America. In Europe, the Survey of Health, Aging ...
Vanherberghen Bruno - - 2013
Despite intense scrutiny of the molecular interactions between natural killer (NK) and target cells, few studies have been devoted to dissection of basic functional heterogeneity in individual NK cell behavior. By using a microchip-based, time-lapse imaging approach allowing the entire contact history of each NK cell to be recorded, we ...
Ahn So Yoon - - 2013
BACKGROUND AND PURPOSE: Severe intraventricular hemorrhage (IVH) in premature infants and the ensuing posthemorrhagic hydrocephalus cause significant mortality and neurological disabilities, and there are currently no effective therapies. This study determined whether intraventricular transplantation of human umbilical cord blood-derived mesenchymal stem cells prevents posthemorrhagic hydrocephalus development and attenuates brain damage ...
Pathem Bala Krishna - - 2013
Dihydroazulenes are photochromic molecules that reversibly switch between two distinct geometric and conductivity states. Molecular design, surface attachment, and precise control over the assembly of such molecular machines are critical in order to understand molecular function and motion at the nanoscale. Here, we use surface-enhanced Raman spectroscopy on special atomically ...
Martin Emily T - - 2013
Background. The identification of multiple viruses during respiratory illness is increasing with advances in rapid molecular testing, however the epidemiology of respiratory viral coinfections is not well known.Methods. 225 childcare attendees were prospectively followed for up to 2 years. Nasal swabs were collected at respiratory illness onset and every 7-10 days until ...
Yost Kathleen J - - 2013
BACKGROUND: Patient-reported signs and symptoms are often the first indication of clinically relevant lymphedema. OBJECTIVE: Develop and assess the diagnostic accuracy of a screening questionnaire to detect lower extremity lymphedema (LEL) among normal weight and obese women. DESIGN: Cross-sectional survey study. METHODS: We reviewed existing questionnaires assessing upper extremity lymphedema ...
< 12 13 14 15 16 17 18 19 20 21 22 >