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Chandra Dinesh D Department of Cardiothoracic and Vascular Surgery, PGIMER and Dr RML Hospital, New Delhi, - - 2013
A best evidence topic in cardiac surgery was written according to the structured protocol. The question addressed was about the best time to restart anticoagulation in patients with intracranial bleed with a prosthetic valve in situ. This difficult clinical decision has to balance the risk of thromboembolism during the period ...
Wang Chen - - 2013
The need to operate proton exchange membrane fuel cells under hot and dry conditions has driven the synthesis and testing of sulfonated poly(phenylene) sulfone (sPSO2) ionomers. The primary hydration and energetics associated with the transfer of protons in oligomeric fragments of two sPSO2 ionomers were evaluated through first principles electronic ...
Xiao Xiang X The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, 1230 York Avenue, New York, NY 10065, - - 2013
During the seminiferous epithelial cycle, restructuring takes places at the Sertoli-Sertoli and Sertoli-germ cell interface to accommodate spermatogonia/spermatogonial stem cell renewal via mitosis, cell cycle progression and meiosis, spermiogenesis and spermiation since developing germ cells, in particular spermatids, move 'up and down' the seminiferous epithelium. Furthermore, preleptotene spermatocytes differentiated from ...
Cao Zheng - - 2013
Improved methods for studying glycans could spur significant advances in the understanding and application of glycobiology. The use of affinity reagents such as lectins and glycan-binding antibodies is a valuable complement to methods involving mass spectrometry and chromatography. Many lectins, however, are not useful as analytic tools due to low ...
Jowett V - - 2013
The ductus venosus (DV) connects the portal venous system to the inferior vena cava (IVC). Rare abnormalities arise where umbilical venous drainage is anomalous connecting either to the portal sinus within the liver or an extra hepatic connection where it bypasses the liver and may drain to a variety of ...
Karoui S - - 2013
CoPt equiatomic alloy orders according to the tetragonal L1(0) structure which favors strong magnetic anisotropy. Conversely, magnetism can influence the chemical ordering. We present here ab initio calculations of the stability of the L1(0) and L1(2) structures of Co-Pt alloys in their paramagnetic and ferromagnetic states. They show that magnetism ...
Dequatre-Ponchelle Nelly - - 2013
BACKGROUND AND PURPOSE: The high prevalence of atrial fibrillation in aging populations leads to an increasing incidence of vitamin K antagonists-associated intracerebral hemorrhages (VKAs-ICH). It remains unclear whether VKAs are causes or risk factors for ICH. We aimed at identifying the specificities of VKAs-ICH. METHODS: We compared baseline characteristics of ...
Jurczyk Matthew - - 2013
Epithelioid hemangioendothelioma (EHE) of the liver is an extremely rare tumor that masquerades as an epithelial neoplasm and poses significant diagnostic pitfalls for the cytopathologist. This report describes a 64-year-old woman whom on computerized tomography was found to have multiple peripherally calcified hypodense lesions throughout the liver and an ipsilateral ...
Chatzidionysiou K - - 2013
Objective: The purpose of this study was to characterize and compare responses in patients who had failed one tumour necrosis factor (TNF) inhibitor when switching to another TNF inhibitor or rituximab (RTX). Methods: The Stockholm TNF follow-up registry (STURE) was used. Treatment results at 6 months were analysed by (i) ...
Gregersen Jw - - 2013
Objectives: The combination of anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) and severe infection presents a challenge because current therapies with high-dose glucocorticoids and cyclophosphamide (CYC) are immunosuppressive and increase the risk of infection. Thus, coincident infection delays and complicates the introduction of treatment. Rituximab (RTX) is an alternative to CYC ...
de Jager Saskia C A - - 2013
OBJECTIVE: Despite common disbelief that neutrophils are involved in atherosclerosis, evidence is accumulating for a causal role of neutrophils in atherosclerosis. CCL3 is an inflammatory chemokine and its expression is significantly increased during atherosclerotic lesion formation in mice. It has recently been shown that under conditions of inflammation neutrophils can ...
Johnston William F WF Department of Surgery, University of Virginia, Charlottesville, VA, - - 2013
Abdominal aortic aneurysms (AAAs) are common, but their exact pathogenesis remains unknown and no specific medical therapies are available. We sought to evaluate interleukin-1β (IL-1β) and interleukin-1 receptor (IL-1R) in an experimental AAA model to identify novel therapeutic targets for AAA treatment. IL-1β mRNA and protein levels were significantly elevated ...
Harada Shigeyoshi S Center for AIDS Research, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, - - 2013
The initiation of drug therapy results in a reduction in the human immunodeficiency virus type 1 (HIV-1) population, which represents a potential genetic bottleneck. The effect of this drug-induced genetic bottleneck on the population dynamics of the envelope (Env) regions has been addressed in several in vivo studies. However, it ...
Oborský Pavel - - 2013
Iduronic acid (IdoA), unlike most other monosaccharides, can adopt different ring conformations depending on the context of the molecular structure. Accurate modeling of this building block is essential for understanding the role of glycosaminoglycans and other glycoconjugates. Here, we use metadynamics to predict equilibria of 1C4, 4C1 and 2SO conformations ...
Yang Zhi-Yong - - 2013
The self-assembly of truxenone on highly oriented pyrolytical graphite (HOPG) was investigated with scanning tunneling microscopy (STM) and density functional theory (DFT) calculations. Truxenone assembled into a dense hexagonal adlayer with large and near-perfect domains on the graphite surface. Two types of topography image of truxenone were observed in experiments. ...
Gupta Himani - - 2013
ABSTRACT BACKGROUND: Although chronic obstructive pulmonary disease (COPD) affects large sections of the population, its effects on postoperative outcomes have not been rigorously studied. Our objectives were to describe the prevalence of COPD in patients undergoing surgery and to analyze the associations between COPD and postoperative morbidity, mortality, and length ...
Jain Felipe A - - 2013
BACKGROUND: There are many prognostic factors for treatment outcome in major depressive disorder (MDD). The predictive power of any single factor, however, is limited. We aimed to develop profiles of antidepressant response and remission based upon hierarchical combinations of baseline clinical and demographic factors. METHODS: Using data from Level 1 ...
Kajitani Chikae - - 2013
We analyzed the data for 53 patients with histologically proven primary squamous cell carcinoma of the head and neck treated with radiotherapy between February 2006 and August 2009. All patients underwent contrast-enhanced (CE)-CT and (18)F-fluorodeoxyglucose (FDG)-PET before radiation therapy planning (RTP) to define the gross tumor volume (GTV). The PET-based ...
Kim Jin Seok - - 2013
The type III secretion systems (T3SSs) are exploited by many Gram-negative pathogenic bacteria to deliver a set of effector proteins into host cytosol during cell entry. The T3SS of Salmonella enterica serovar Typhimurium is composed of more than 20 proteins that constitute the membrane-associated base, needle and the tip complex ...
Llurba Elisa - - 2013
Objective: To examine relationships between umbilical and internal carotid artery Doppler findings and cognitive development at 3 and 6 years in small for gestational age (SGA) children. Methods: SGA children (birthweight <10(th) centile) born after 28 weeks' with umbilical artery (UA) resistance index (RI) measured within 2 weeks of delivery. ...
Rintala Tuula-Maria - - 2013
Diabetes mellitus is a common chronic disease all over the world. Self-management plays a crucial role in diabetes management. The purpose of this systematic review was to summarize what is known about the interactions between adult persons with diabetes, their family, and diabetes self-management. MEDLINE, CINAHL, PSYCHINFO, LINDA, and MEDIC ...
Zong Zhiyong - - 2013
OBJECTIVES: This study screened hospital sewage for the presence of bla(NDM). METHODS: Colonies grown from plates containing meropenem streaked with hospital sewage were screened for bla(NDM) by PCR. Species identification was performed by sequencing 16S rRNA genes. Clonal relatedness of isolates was determined by Enterobacterial repetitive intergenic consensus sequence-PCR, sequencing ...
E Qiukai - - 2013
It has been reported that over-expression of GRP75 can protect cells under different types of stress. In this study, we investigated the protective effect of GRP75 on the liver both in vivo and in vitro. To evaluate the effect of GRP75 over-expression on oxidative damage in the liver in vitro, ...
Dellweg Dominic - - 2013
Background:Oxygen therapy is usually combined with a humidification device to prevent mucosal dryness. Depending of the cannula design oxygen can be administered pre- or intra-nasally (administration of oxygen in front of the nasal ostia versus cannula system inside the nasal vestibulum). The impact of the cannula design on intra-nasal humidity ...
Sutherland Jennifer - - 2013
In 2003, the UK Food Standards Agency and the Department of Health began attempts to reduce national salt intakes via reformulation of processed foods and a consumer awareness campaign on the negative impacts of salt on health. The present study uses large nationally representative samples of households in England to ...
Yoon Woong - - 2013
BACKGROUND AND PURPOSE: Subarachnoid hemorrhage (SAH) may appear on computerized tomography scans after mechanical thrombectomy for acute ischemic stroke. The incidence and prognosis of this observation remain unknown. We investigated the frequency and clinical consequences of SAH after treating acute ischemic stroke with multimodal approach heavily weighted toward mechanical thrombectomy ...
Cong Le L Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, - - 2013
Functional elucidation of causal genetic variants and elements requires precise genome editing technologies. The type II prokaryotic CRISPR (clustered regularly interspaced short palindromic repeats)/Cas adaptive immune system has been shown to facilitate RNA-guided site-specific DNA cleavage. We engineered two different type II CRISPR/Cas systems and demonstrate that Cas9 nucleases can ...
Smits M M - - 2013
BACKGROUND AND AIM: The metabolic syndrome (MetS) and each of its components are strongly associated with non-alcoholic fatty liver disease (NAFLD) This has led many investigators to suggest that NAFLD is an independent component of the metabolic syndrome (MetS). We formally tested this hypothesis using Confirmatory Factor Analysis (CFA), which ...
van Poppel Mireille Nm - - 2013
OBJECTIVE: Chemerin is a novel adipokine implicated in inflammation and obesity. We hypothesized that fetal chemerin would be elevated in gestational diabetes mellitus (GDM) and correlate with fetal and maternal adiposity. DESIGN: Observational, longitudinal study SUBJECTS AND MEASUREMENTS: Fetal chemerin was measured separately in arterial and venous cord blood of ...
Gomes Samirah A - - 2013
Although nitric oxide (NO) signaling promotes differentiation and maturation of endothelial progenitor cells, its role in the differentiation of mesenchymal stem cells (MSCs) into endothelial cells remains controversial. We tested the role of NO signaling in MSCs derived from WT mice and mice homozygous for a deletion of S-nitrosoglutathione reductase ...
Boreyko Jonathan B - - 2013
Self-propelled jumping drops are continuously removed from a condensing superhydrophobic surface to enable a micrometric steady-state drop size. Here, we report that subcooled condensate on a chilled superhydrophobic surface are able to repeatedly jump off the surface before heterogeneous ice nucleation occurs. Frost still forms on the superhydrophobic surface due ...
Kristianslund Eirik - - 2013
BACKGROUND:Anterior cruciate ligament (ACL) injuries are a serious problem, with a high incidence and serious consequences. Published clinical screening tests are based on 2-legged and controlled drop jumps, but ACL injuries are known to occur in single-legged landings and sidestep cutting, where the load is predominantly distributed to a single ...
Yu Hong-Mei - - 2013
ABSTRACT Background: Although knowledge of established risk factors for Alzheimer's disease (AD) can logically contribute to the search for predictors of the progression of cognitive impairment, it has not yet been firmly established where in the cognitive impairment process these risk factors exert their effects and how to predict quantitatively ...
Fratangeli Alessandra A Consiglio Nazionale delle Ricerche-Institute of Neuroscience, Department of Medical Biotechnologies and Translational Medicine, University of Milan, Milan 20129, - - 2013
GPR17 is a G-protein-coupled receptor that is activated by two classes of molecules: uracil-nucleotides and cysteinyl-leukotrienes. GPR17 is required for initiating the differentiation of oligodendrocyte precursors but has to be down-regulated to allow cells to undergo terminal maturation. Although a great deal has been learned about GPR17 expression and signaling, ...
Scott Ian C - - 2013
Objectives. Our aim was to establish whether alcohol protects against RA development and to determine whether this effect is influenced by alcohol dose, duration and serological status through systematically reviewing the literature and undertaking a meta-analysis.Methods. We searched Medline/EMBASE (1946 to July 2012) using the terms rheumatoid arthritis.mp or arthritis, ...
Arslan Erol - - 2013
Arterial stiffness is currently the "gold standard" measure of aortic (carotid-femoral) pulse wave velocity (PWV), which is an important independent predictor of risk of developing a cardiovascular event. Gilbert's syndrome is a congenital disorder characterized by intermittent and non-hemolytic elevation of indirect bilirubin levels due to the deficiency of the ...
Rahimi Robert S - - 2013
The prevalence of nonalcoholic fatty liver disease (NAFLD) is expected to rise along with the global obesity epidemic. As NAFLD is the most common cause of chronic liver disease in the United States, it has become a major health concern. It affects all ethnicities, with the highest prevalence among the ...
Alsulaimani Sara S Department of Neurology, Miller School of Medicine, University of Miami, Clinical Research Bldg 1120, NW 14 St, Miami, FL 33136, - - 2013
Studies have linked elevated total homocysteine (tHcy) levels to atherosclerotic carotid plaque development, but data are limited to predominantly white populations. We examined the association between tHcy and carotid plaque burden and morphology in a multiethnic cohort. In the Northern Manhattan Study, we conducted a cross-sectional analysis among 1327 stroke-free ...
Engel Samuel S - - 2013
ABSTRACT: OBJECTIVE: To compare the incidence of cardiovascular events and mortality in patients with type 2 diabetes mellitus treated with sitagliptin or non-sitagliptin comparators. METHODS: A post hoc assessment of cardiovascular safety in 14,611 patients was performed by pooling data from 25 double-blind studies, which randomised patients at baseline to ...
Iglesias Emilia - - 2013
The nitrosation of acetylacetone (AcAc) has been revised in an aqueous acid medium of perchloric acid and buffers of mono-, di-, or tri-chloroacetic acid. The results show that in the presence of buffers, under conditions of [nit] ≪ [AcAc] (nit = sodium nitrite) the reaction cannot be studied by UV-Vis ...
Kang Jianli - - 2013
Electrochemical energy storage: The performance of MnO(2) as a pseudo-capacitive material was enhanced by doping electrodeposited MnO(2) with physically deposited gold atoms. The resulting MnO(2) electrodes showed an enhanced electronic conductivity and a remarkable stability under voltammetric cycling.
Plaza-Zamora J - - 2013
Maternal milk is the first source of exogenous polyamines for the newborn. Polyamines modulate gut maturation in neonates, but no studies are available on polyamine concentration in human milk of preterm babies, even though they could be important for their immature gut. The present study aimed to determine polyamine concentration ...
Chen Jiandong J Department of Biochemistry and Molecular Biology, The University of Texas Medical School at Houston, Houston, Texas 77030, - - 2013
The Drosophila integrator complex consists of 14 subunits that associate with the C terminus of Rpb1 and catalyze the endonucleolytic cleavage of nascent snRNAs near their 3' ends. Although disruption of almost any integrator subunit causes snRNA misprocessing, very little is known about the role of the individual subunits or ...
Ennemann Eva C EC Department of Chemistry, Biochemistry I, Bielefeld University, 33615 Bielefeld, - - 2013
Formylglycine-generating enzyme (FGE) post-translationally converts a specific cysteine in newly synthesized sulfatases to formylglycine (FGly). FGly is the key catalytic residue of the sulfatase family, comprising 17 nonredundant enzymes in human that play essential roles in development and homeostasis. FGE, a resident protein of the endoplasmic reticulum, is also secreted. ...
Seror Raphaèle - - 2013
Objective. To determine the pattern of demyelinating disorders (DDs) occurring during anti-TNF-α therapy.Methods. Between June 2005 and April 2008, 1800 French rheumatologists and internists were contacted to report cases of DDs occurring in patients treated with anti-TNF-α.Results. After a median of 10.2 (1.5-39.9) months of treatment, 33 patients developed DDs: ...
Møller M H - - 2013
BACKGROUND: Mortality and morbidity are considerable after treatment for perforated peptic ulcer (PPU). Since 2003, a Danish nationwide quality-of-care (QOC) improvement initiative has focused on reducing preoperative delay, and improving perioperative monitoring and care for patients with PPU. The present study reports the results of this initiative. METHODS: This was ...
Taylor E F EF Northern and Yorkshire Cancer Registry and Information Service, St James's Institute of Oncology, St James's University Hospital, Leeds, - - 2013
Clinical guidelines recommend that, where clinically appropriate, laparoscopic tumour resections should be available for patients with colorectal cancer. This study aimed to examine the introduction of laparoscopic surgery in the English National Health Service. Data were extracted from the National Cancer Data Repository on all patients who underwent major resection ...
Ansai Satoshi S Division of Applied Bioscience, Graduate School of Agriculture Kyoto University, Sakyo-ku, Kyoto, - - 2013
Transcription activator-like effector nucleases (TALENs) have become powerful tools for targeted genome editing. Here we demonstrate efficient targeted mutagenesis in medaka (Oryzias latipes), which serves as an excellent vertebrate model for genetics and genomics. We designed and constructed a pair of TALENs targeting the medaka DJ-1 gene, a homolog of ...
Wang Shu - - 2013
ABSTRACT The disinfection by-products, 3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone (MX) and microcystins-LR (MC-LR), common contaminants in drinking water, often occur together in water sources in areas with high gastrointestinal tract cancer risks. While often studied alone, combination effects of these compounds are unknown. Here, we examine combined genotoxic responses to mixtures of MX and ...
Pitance L - - 2013
Abstract Background: Open-vent jet nebulizers are frequently used to promote drug deposition in the lung, but their clinical efficacy and indications are not clear. Our study compared lung deposition of amikacin using two different configurations of a jet nebulizer (Sidestream(®)): one vented (N(1)) and one unvented with a corrugated piece ...
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