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Kapur Narinder N University College London, London, UK. - - 2013
Disorders of the brain and its sensory organs have traditionally been associated with deficits in movement, perception, cognition, emotion, and behavior. It is increasingly evident, however, that positive phenomena may also occur in such conditions, with implications for the individual, science, medicine, and for society. This article provides a selective ...
Mali Prashant - - 2013
Bacteria and archaea have evolved adaptive immune defenses, termed clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems, that use short RNA to direct degradation of foreign nucleic acids. Here, we engineer the type II bacterial CRISPR system to function with custom guide RNA (gRNA) in human cells. For the ...
Thornton Paul D - - 2013
The generation of a range of star-shaped block copolymers composed of a biocompatible poly(ethylene glycol) (PEG) core tethered to a polyalanine (PAla) shell that possesses the capability to (reversibly) self-assemble in water is described. The hydrogels formed offer a hydrophilic environment ideal for biological processes involving proteins and are able ...
Annett R W - - 2013
A study was undertaken to investigate the performance of breeding ewes fed a range of forage and concentrate-based diets in late pregnancy, balanced for supply of metabolizable protein (MP). For the final 6 weeks before lambing, 104 twin-bearing multiparous ewes were offered one of four diets: ad libitum precision-chop grass ...
Johnsen Lærke - - 2013
Mounting evidence led us to hypothesize that: 1) function of the thyroid hormone (TH) axis can be programmed by late-gestation undernutrition (LG-UN), and 2) early-postnatal-life overnutrition (EL-ON) exacerbates the fetal impacts on TH-axis function. In a 2×2 factorial experiment, 21 twin-bearing sheep were fed one of two diets during late ...
Massollo Michela - - 2013
In the course of metformin treatment, staging abdominal cancer lesions with (18)F-FDG PET images is often hindered by the presence of a high bowel radioactivity. The present study aimed to verify the mechanism underlying this phenomenon. METHODS: Fifty-three mice were submitted to dynamic acquisitions of (18)F-FDG kinetics under fasting conditions. ...
Sherr Jennifer J Yale University, New Haven, Connecticut, - - 2013
To examine the loss of glucagon response to hypoglycemia and its relationship with residual β-cell function early in the course of type 1 diabetes (T1D) in youth. Twenty-one youth with T1D duration <1 year (ages 8-18 years, T1D duration 6-52 weeks) underwent mixed-meal tolerance tests (MMTTs) to assess residual β-cell ...
Boskovic Jelena - - 2013
Aims: The aims of this study was to determine adherence to chronic disease medication measured by self-reported questionnaire. Methods: The survey was conducted at 106 Zagreb pharmacies, and the questionnaire was filled out by the study subjects. Results: A total 1,357 diagnoses were reported by survey respondents (i.e., an average ...
Seo Seongjin S Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, - - 2013
Copy number variations (duplications) of TANK binding kinase 1 (TBK1) have been associated with normal tension glaucoma (NTG), a common cause of blindness worldwide. Mutations in other genes involved in autophagy (TLR4 and OPTN) have been associated with NTG. Here we report searching for additional proteins involved in autophagy that ...
Takahashi Yoshinori Y Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA 17033, - - 2013
Malignant transformation by oncogenes requires additional genetic/epigenetic changes to overcome enhanced susceptibility to apoptosis. In the present study, we report that Bif-1 (Sh3glb1), a gene encoding a membrane curvature–driving endophilin protein, is a haploinsufficient tumor suppressor that plays a key role in the prevention of chromosomal instability and suppresses the ...
Park S H - - 2013
INTRODUCTION: The CellaVision DM96 system (CellaVision AB, Lund, Sweden) was developed as one of the automated digital cell morphology analyzer for determining leukocyte differential counts in peripheral blood smears (PBS) and we evaluated this system. METHODS: A total of 308 PB samples with abnormalities were analyzed in this study. For ...
Drenner Ray W - - 2013
Mercury (Hg) is a toxic metal that is found in aquatic food webs and is hazardous to human and wildlife health. We examined the relationship between Hg deposition, land coverage by coniferous and deciduous forests and average Hg concentrations in largemouth bass (Micropterus salmoides) equivalent fish (LMBE) in 14 ecoregions ...
Hao Zhenhua - - 2013
Thermoresponsive synergistic hydrogen bonding (H-bonding) switched by several guest units in a water-soluble polymer is reported. Adjusting the distribution of guest units can effectively change the synergistic H-bonding inside polymer chains, thus widely switch the preorganization and thermoresponsive behavior of a water-soluble polymer. The synergistic H-bonding is also evidenced by ...
Yuan Hong - - 2013
Ovarian cancer is a highly invasive and metastatic disease with a poor prognosis if diagnosed at an advanced stage, which is often the case. Recent studies argue that ovarian cancer cells that have undergone epithelial to mesenchymal transition (EMT) acquire aggressive malignant properties, but the relevant molecular mechanisms in this ...
Stellmes Arno A Department of Cardiovascular Surgery, University Hospital Berne, Berne, - - 2013
To evaluate thoracic endovascular aortic repair (TEVAR) as emergency therapy despite suspected aortic infection. Within a 5-year period, we treated 6 patients with a strategy of primary TEVAR despite suspected aortic infection in patients with symptomatic or already ruptured thoracic aortic pathology. In-hospital mortality was 16.7%. The reason for death ...
Ma Xiao-Song - - 2013
The counterintuitive features of quantum physics challenge many common-sense assumptions. In an interferometric quantum eraser experiment, one can actively choose whether or not to erase which-path information (a particle feature) of one quantum system and thus observe its wave feature via interference or not by performing a suitable measurement on ...
Coadou Erwan - - 2013
Herein, we present a comparative study of thermophysical properties of two homologous ionic liquids, namely trimethyl-sulfonium bis[(trifluoromethyl)sulfonyl]imide, [S111][TFSI], and trimethyl-ammonium bis[(trifluoromethyl)sulfonyl]imide, [HN111][TFSI], and their mixtures with propylene carbonate, acetonitrile or gamma butyrolactone as a function of temperature and composition. The influence of solvent addition on the viscosity, conductivity and thermal ...
Wang Meiyao - - 2013
CD4 (cluster of differentiation 4) is an important glycoprotein containing a transmembrane portion and a short intracellular tail. It locates on the surface of various types of immune cells and performs a critical role in multiple cellular functions such as signal amplification and activation of T cells. It is well ...
Chimienti Fabrice - - 2013
Zn is an essential trace element, involved in many different cellular processes. A relationship between Zn, pancreatic function and diabetes was suggested almost 70 years ago. To emphasise the importance of Zn in biology, the history of Zn research in the field of diabetes along with a general description of ...
Chen Lena M LM Division of General Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. - - 2013
Payers are increasingly holding hospitals accountable for patients' experiences with their care. This may conflict with another trend among US hospitals-greater hospitalist care-as hospitalists may have less familiarity with the history and preferences of their patients compared with primary-care physicians. Our objective was to better understand the relationship between hospitalist ...
Majumdar Arka - - 2013
Efficient conversion of electrical signal to optical signal in nano-photonics enables solid state integration of electronics and photonics. Combination of graphene with photonic crystals is promising for electro-optic modulation. In this paper, we demonstrate that by electrostatic gating a single layer of graphene on top of a photonic crystal cavity, ...
Park Young Min - - 2013
OBJECTIVES/HYPOTHESIS: The objective of this prospective study was to confirm the validity of transoral robotic supraglottic partial laryngectomy as a conservation surgery for treating supraglottic cancer. STUDY DESIGN: Prospective case study. METHODS: Between December 2009 and November 2011, 16 patients were enrolled in this study. Acoustic waveform analysis was conducted ...
Vasileiadis Ioannis - - 2013
Symmetrical lipomatosis of the tongue is an extremely rare condition. To date, only eight cases have been reported in the literature. We present an extremely rare case of intramuscular lipomatosis of the tongue in a 67-year-old male. The present case is unique because of its infiltrating nature and the extension ...
Kufner Anna - - 2013
The so-called smoking-thrombolysis paradox of an improved outcome after thrombolysis was first described in smokers with myocardial infarction. We investigated whether reperfusion rates and clinical outcome differ between smokers and nonsmokers with ischemic stroke after intravenous tissue plasminogen activator. Consecutive acute ischemic stroke patients, who had magnetic resonance imaging before ...
Kim S H - - 2013
BACKGROUND: Complication rates of living-donor right hepatectomy remain a matter of major concern. The aim of this study was to achieve near-zero morbidity for living-donor right hepatectomy in a single centre. METHODS: All living donors who underwent right hepatectomy between January 2005 and September 2011 were enrolled in this retrospective ...
Lee Gyunghee - - 2013
Dysfunctional regulation of brain dopamine (DA) functions has been found in patients with drug addiction and various neurological disorders that frequently accompany disturbance in sleep behavior. In this study, the roles of the dopaminergic nervous system on the regulation of daily locomotor activity rhythm were investigated in Drosophila melanogaster. Reduced ...
de Ciuceis Carolina - - 2013
It is not known whether, in obesity, the capillary density or the number of circulating endothelial progenitor cells (EPCs) are reduced, or whether fibrosis of small vessels is also present. In addition, possible effects of weight reduction on these parameters have never been evaluated. Therefore, we investigated EPCs and capillary ...
Armigliato Aldo - - 2013
A method for the fabrication of a wedge-shaped thin NiO lamella by focused ion beam is reported. The starting sample is an oxidized bulk single crystalline, ⟨100⟩ oriented, Ni commercial standard. The lamella is employed for the determination, by analytical electron microscopy at 200 kV of the experimental k(O-Ni) Cliff-Lorimer ...
Shintani Yasushi Y Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan. - - 2013
Although video-assisted thoracoscopic surgery (VATS) is widely used for the resection of a mediastinal mass, it is converted to an open resection in some patients with a mature teratoma because of dense adhesions. We reviewed cases with a mature teratoma removed by VATS and investigated the indications for that procedure ...
Gering F - - 2013
The Fukushima accident led to high radionuclide releases into the atmosphere for more than 3 weeks. This situation has not been assumed when the concepts of nuclear emergency preparedness were developed internationally. The results of simulations studying potential implications of Fukushima-like source terms on nuclear emergency preparedness are presented. Two ...
Romero Jennifer V - - 2013
Impregnated activated carbons (IAC) are widely used materials for the removal of toxic gases in personal respiratory protection applications. The combinatorial method has been employed to prepare IACs containing different types of metal oxides in various proportions and evaluate their adsorption performance for low molecular weight gases such as SO2 ...
Pessach Ilias - - 2013
BACKGROUNDHematopoietic growth factors (HGFs) are mostly used as supportive measures to reduce infectious complications associated with neutropenia. Over the past decade, the use of HGFs became a common method for mobilizing human CD34+ stem cells, either for autologous or allogeneic transplantation. However, since their introduction the long-term safety of the ...
Yu Dong-Jun - - 2013
Understanding the interactions between proteins and ligands is critical for protein function annotations and drug discovery. We report a new sequence-based template-free predictor (TargetATPsite) to identify the Adenosine-5'-triphosphate (ATP) binding sites with machine-learning approaches. Two steps are implemented in TargetATPsite: binding residues and pockets predictions, respectively. To predict the binding ...
Ko Y J - - 2013
INTRODUCTION: Immature platelet fraction (IPF) is a parameter for reticulated platelets. A high percentage IPF (%-IPF) is indicative of consumptive or recovering thrombocytopenic disorders in contrast to a low %-IPF seen in aplastic states. Absolute IPF (A-IPF) specifically reflects the number of immature platelets in circulation. This study aimed to ...
Rosefort Audrey - - 2013
Abstract Chorioangioma is the most common benign vascular placental tumor. It is often small and has no clinical significance. Large chorioangiomata are rarer and can lead to fetal or maternal complications. Chorangiomatosis or chorioangomatosis is even rarer and is defined as a focal or multifocal proliferation of placental capillaries permeating ...
Albrecht Karoline - - 2013
OBJECTIVE: The purpose of this study was to explore the impact of self-efficacy for coping with cancer (SECC) on physical fatigue and depressive symptoms in melanoma patients, in comparison with objective factors, such as treatment with interferon-alpha (IFN-α) and medical and sociodemographic variables. Current literature shows that psychological distress in ...
Hatfield M Jason MJ Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, - - 2013
The roots of Salvia miltiorrhiza ("Danshen") are used in traditional Chinese medicine for the treatment of numerous ailments including cardiovascular disease, hypertension, and ischemic stroke. Extracts of S. miltiorrhiza roots in the formulation "Compound Danshen Dripping Pill" are undergoing clinical trials in the United States. To date, the active components ...
Tamaki Kentaro - - 2013
Breast cancer mortality is gradually increasing in Okinawa. The 1st Okinawa Breast Oncology Meeting was held on 6 July 2012 and discussions on how to curb the rising trend were focused on breast cancer screening, adjuvant treatment, socioeconomic and geographic issues, and the problem of complementary and alternative medicine. The ...
Vines Timothy H - - 2013
The data underlying scientific papers should be accessible to researchers both now and in the future, but how best can we ensure that these data are available? Here we examine the effectiveness of four approaches to data archiving: no stated archiving policy, recommending (but not requiring) archiving, and two versions ...
Kaddour Hadhemi - - 2013
Oxidative stress, induced by various neurodegenerative diseases, initiates a cascade of events leading to apoptosis, and thus plays a critical role in neuronal injury. In this study, we have investigated the potential neuroprotective effect of the octadecaneuropeptide (ODN) on 6-hydroxydopamine (6-OHDA)-induced oxidative stress and apoptosis in cerebellar granule neurons (CGN). ...
Porat Shay - - 2013
Objectives: To determine the pathologic basis and clinical associations of excessively thick placentas observed at second-trimester ultrasound examinations. Methods: Maximum sonographic placental thickness was correlated with clinical outcomes, maximum placental thickness after delivery and placental pathologic findings in a retrospective cohort of 19 singleton high-risk pregnancies noted to have a ...
Xia Ai-Bao - - 2013
The organocatalytic Michael reaction of ketones with gamma-monohalonitrodienes catalyzed by chiral prolinethiol ether under solvent-free conditions was developed. The described method represents a novel approach for accessing highly functionalized monohaloalkenes with alpha, beta-stereocenters of up to >99% ee.
Dewitt Douglas - - 2013
Approximately 75% of traumatic brain injuries (TBI) are classified mild (mTBI). Despite the high frequency of mTBI, it is the least well studied. The prevalence of mTBI among service personnel returning from Operations Iraqi Freedom (OIF) and Enduring Freedom (OEF) and the recent reports of an association between repeated mTBI ...
Hyma Katie E KE Evolution, Ecology and Population Biology Program, Washington University, St. Louis, MO 63130, USA. - - 2013
Humans have had a significant impact on the distribution and abundance of Saccharomyces cerevisiae through its widespread use in beer, bread and wine production. Yet, similar to other Saccharomyces species, S. cerevisiae has also been isolated from habitats unrelated to fermentations. Strains of S. cerevisiae isolated from grapes, wine must ...
Tripuraneni Manasa - - 2013
OBJECTIVES/HYPOTHESIS: To study the correlation between obstructive sleep apnea (OSA), obesity, behavior, and quality of life. STUDY DESIGN: Case-control study of pediatric OSA documented by polysomnography at a tertiary-care hospital. METHODS: Caregivers signed a consent document and completed the Behavior Assessment System for Children (BASC-2) and the 18-item OSA Quality-of-Life ...
Chapman Robert - - 2013
Multi-shell nanotubes containing poly(acrylic acid) external shell and polyisoprene internal shells are prepared by exploiting the self-assembly of an alt-(d,l) cyclic peptide template. Crosslinking of the acrylic acid shell, followed by ozonolysis of the polyisoprene, gives access to nanotubes with an internal pore which can be controlled by the degree ...
Dreier Jens P - - 2013
BACKGROUND AND PURPOSE: Clinical and experimental evidence suggests that spreading depolarization facilitates neuronal injury when its duration exceeds a certain time point, termed commitment point. We here investigated whether this commitment point is shifted to an earlier period, when spreading depolarization is accompanied by a perfusion deficit. METHODS: Electrophysiological and ...
McRae Andrew D - - 2013
ABSTRACT: BACKGROUND: Cluster randomized trials (CRTs) pose ethical challenges for investigators and ethics committees. This study describes the views and experiences of CRT researchers with respect to: (1) ethical challenges in CRTs; (2) the ethics review process for CRTs; and (3) the need for comprehensive ethics guidelines for CRTs. METHODS: ...
Mikkelsen Kim Lyngby - - 2013
OBJECTIVE: Validation of a Danish patient safety incident classification adapted from the World Health Organizaton's International Classification for Patient Safety (ICPS-WHO). DESIGN: /st>Thirty-three hospital safety management experts classified 58 safety incident cases selected to represent all types and subtypes of the Danish adaptation of the ICPS (ICPS-DK).Outcome MeasuresTwo measures of ...
Gimenez G - - 2013
SUMMARY The intra-erythrocytic protozoan Babesia bovis is an economically important pathogen that causes an acute and often fatal infection in adult cattle. Babesiosis limitation depends on the early activation of macrophages, essential cells of the host innate immunity, which can generate an inflammatory response mediated by cytokines and nitric oxide ...
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