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Results 601 - 650 of 2749
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Xu Hong-Bin - - 2013
We sought to evaluate the efficacy of elemene in cancer treatment. We searched the literature using several databases up to October 2011. Thirty-eight trials met inclusion criteria. The meta-analysis demonstrated that elemene plus chemotherapy was associated with a significant rise in the number of patients who reported improved tumor response, ...
Okubo Shingo - - 2013
Circulating liver-specific mRNAs such as albumin (Alb) and α-1 microglobulin/bikunin precursor (Ambp) mRNAs have been reported to be potential biomarkers for drug-induced liver injury (DILI). We identified novel circulating liver-specific mRNAs and quantified them, together with the two previously reported mRNAs, in plasma from rats treated with various hepatotoxicants to ...
Kepler R M - - 2013
Entomopathogenic fungi in the genus Metarhizium are useful for biological control programmes against economically important arthropod pests worldwide. However, understanding the true diversity and ecology of these organisms is hampered by convergent morphologies between species. The application of molecular techniques has enabled greater resolution of species than allowed by morphology ...
Wu Heng-Qing - - 2013
In this work, we add different strength of external electric field (E(ext) ) along molecule axis (Z-axis) to investigate the electric field induced effect on HArF structure. The H-Ar bond is the shortest at E(ext) = -189 × 10(-4) and the Ar-F bond show shortest value at E(ext) = -185 ...
Parra-Saavedra M - - 2013
Objectives: To compare umbilical vein (UV) flow versus standard Doppler parameters in prediction adverse perinatal outcomes in late-onset small-for gestational age (SGA) fetuses. Methods: Umbilical, uterine, and middle cerebral arteries, and UV blood flow (UVBF) were evaluated by Doppler before delivery in a cohort of 193 term SGA fetuses. The ...
Balestrini Simona - - 2013
BACKGROUND AND PURPOSE: This study aimed at evaluating whether ultrasound monitoring of moderate asymptomatic carotid stenosis may help in identifying subjects at high risk for vascular events. METHODS: We included 523 subjects with unilateral asymptomatic carotid stenosis of 50% to 69%. Follow-up carotid ultrasound was performed within 12 months from ...
Valkenet Karin - - 2013
Inspiratory muscle training (IMT) before cardiac surgery has proved to be a promising intervention to reduce postoperative pneumonia in a randomized controlled trial setting. Effects of IMT in routine care have not been reported. The purpose of this study was to investigate the effect of IMT before cardiac surgery on ...
Wallace Alison E - - 2013
OBJECTIVE: During pregnancy, fetal trophoblast disrupt endothelial cell and vascular smooth muscle cell (VSMC) interactions in spiral arteries of the maternal decidua to enable increased nutritional and oxygen delivery to the fetus. Little is known regarding this transformation because of difficulties of studying human pregnancy in vivo. This study investigated ...
Violi Francesco - - 2013
OBJECTIVE: NADPH oxidase, one of the most important enzymes producing reactive oxidant species, is suggested to play a role in experimental atherosclerosis, but its role in human atherosclerosis is still unclear. We hypothesized that a reduced activity of NADPH oxidase might be linked to a reduced atherosclerotic burden. METHODS AND ...
Kolesnikova Larissa - - 2013
The epithelium of conducting airways represents the main target for influenza virus in mammals, however peculiarities of virus interactions with differentiated airway epithelial cells remain largely unknown. We studied influenza virus budding in differentiated cultures of human tracheo-bronchial epithelial cells by using transmission electron microscopy. Budding of spherical and filamentous ...
Poole Daniel P DP Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052, - - 2013
G protein-coupled receptors of nociceptive neurons can sensitize transient receptor potential (TRP) ion channels, which amplify neurogenic inflammation and pain. Protease-activated receptor 2 (PAR(2)), a receptor for inflammatory proteases, is a major mediator of neurogenic inflammation and pain. We investigated the signaling mechanisms by which PAR(2) regulates TRPV4 and determined ...
Vreuls C P H CP Department of Pathology, Maastricht University Medical Centre, Maastricht, The Netherlands. - - 2013
Oxaliplatin is used as a neo-adjuvant therapy in hepatic colorectal carcinoma metastasis. This treatment has significant side effects, as oxaliplatin is toxic to the sinusoidal endothelial cells and can induce sinusoidal obstruction syndrome (SOS), which is related to decreased overall survival. Glutathione has an important role in the defence system, ...
Foster E D ED Department of Biostatistics, College of Public Health, University of Iowa, 105 River Street, Iowa City, IA 52242, USA. - - 2013
The incidence of myocardial infarctions and influenza follow similar seasonal patterns. To determine if acute myocardial infarctions (AMIs) and ischaemic strokes are associated with influenza activity, we built time-series models using data from the Nationwide Inpatient Sample. In these models, we used influenza activity to predict the incidence of AMI ...
Bekelis K - - 2013
BACKGROUND: There is significant variation in the indications for intervention in patients with recurrent carotid artery stenosis. The aim of the present study was to describe these indications in a contemporary cohort of patients. METHODS: This was a systematic review of all peer-reviewed studies reporting on the indications for carotid ...
Ghoneum Mamdooh - - 2013
The aim of the current study is to examine the protective effect of MGN-3 on overall maintenance of hematopoietic tissue after γ-irradiation. MGN-3 is an arabinoxylan from rice bran that has been shown to be a powerful antioxidant and immune modulator. Swiss albino mice were treated with MGN-3 prior to ...
Sankaranarayanan Sandhya S Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, - - 2013
An important mechanism contributing to cell cholesterol efflux is aqueous transfer in which cholesterol diffuses from cells into the aqueous phase and becomes incorporated into an acceptor particle. Some compounds can enhance diffusion by acting as shuttles transferring cholesterol to cholesterol acceptors, which act as cholesterol sinks. We have examined ...
Everett Brendan M BM Division of Preventive Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, - - 2013
Animal data suggest that natriuretic peptides play an important role in energy metabolism, but prospective studies evaluating a relationship between these peptides and type 2 diabetes mellitus (T2DM) in humans are few and results are conflicting. We used a prospective case-cohort approach (n = 491 T2DM cases, n = 561 ...
Zhou Bingwei - - 2013
The first manganese-catalyzed aromatic C-H alkenylation with terminal alkynes is described. The procedure features an operationally simple catalyst system containing commercially available MnBr(CO)5 and dicyclohexylamine (Cy2NH). The reaction occurs readily in a highly chemo-, regio-, and stereoselective manner delivering anti-Markovnikov E-configured olefins in high yields. Experimental study and DFT calculations ...
Elshahawi Sherif I - - 2013
Shipworms are marine wood-boring bivalve mollusks (family Teredinidae) that harbor a community of closely related Gammaproteobacteria as intracellular endosymbionts in their gills. These symbionts have been proposed to assist the shipworm host in cellulose digestion and have been shown to play a role in nitrogen fixation. The genome of one ...
Sneitz Nina - - 2013
The glucuronidation of estriol, 16-epiestriol and 17-epiestriol by the human UDP-glucuronosyltransferases (UGTs) of subfamilies 1A, 2A and 2B was examined. UGT1A10 is highly active in the conjugation of the 3-OH in all these estriols, whereas UGT2B7 is the most active UGT toward one of the ring D hydroxyls, the 16-OH ...
Liu Qingyun Q Key Laboratory of Medical Molecular Virology, Institutes of Biomedical Sciences and Institute of Medical Microbiology, Fudan University, Shanghai 200032, People's Republic of - - 2013
Resistance to anti-tuberculosis (TB) drugs has been a great challenge for global TB control. Limited tools have been developed to detect resistance to second-line drugs that are associated with extensively drug-resistant (XDR) TB. In this study we aimed to develop a simple and widely applicable assay for detecting mutations associated ...
De Bellis Annamaria - - 2013
Background: Pituitary and thyroid autoimmunity can be triggered by pregnancy. We report the first association of combined growth hormone (GH) and prolactin secretion deficiency due to autoimmune damage to GH- and prolactin- secreting cells in a patient with post delivery lactational failure, presenting subsequently with primary autoimmune hypothyroidism. Patient Findings: ...
Hedl Matija M Department of Internal Medicine, Yale University, New Haven, CT 06520, - - 2013
Upon chronic microbial exposure and pattern-recognition receptor (PRR) stimulation, myeloid-derived cells undergo a distinct transcriptional program relative to acute PRR stimulation, with proinflammatory pathways being downregulated. However, other host-response pathways might be differentially regulated, and this concept has been relatively unexplored. Understanding mechanisms regulating chronic microbial exposure outcomes is important ...
Qin Changming - - 2013
The rhodium-catalyzed reaction of 2-diazo-5-arylpent-4-enoates can be controlled by the appropriate choice of catalyst and catalyst loading to form either 2-arylbicyclo[1.1.0]butane carboxylates or cyclohexene derivatives. Both products are produced in a highly diastereoselective manner, with 2-arylbicyclo[1.1.0]butane carboxylates preferentially formed under low catalyst loadings. When the reaction is catalyzed by Rh(2)(R-BTPCP)(4), ...
Grinsted L - - 2013
Reproductive partitioning is a key component of social organization in groups of cooperative organisms. In colonies of permanently social spiders of the genus Stegodyphus less than half of the females reproduce, while all females, including nonreproducers, perform suicidal allo-maternal care. Some theoretical models suggest that reproductive skew is a result ...
Li Wenyang - - 2013
Background:A systematic review and meta-analysis was performed to compare the outcomes of oral appliances (OA) with those of continuous positive airway pressure (CPAP) in treatment of patients with obstructive sleep apnea (OSA).Methods:Relevant studies were retrieved from the following electronic databases up to and including Semptember 2012: MEDLINE, PubMed, EMBASE, and ...
Konishi Teruaki - - 2013
The Single Particle Irradiation system to Cell (SPICE) facility at the National Institute of Radiological Sciences (NIRS) is a focused vertical microbeam system designed to irradiate the nuclei of adhesive mammalian cells with a defined number of 3.4 MeV protons. The approximately 2-μm diameter proton beam is focused with a ...
Al Shuaibi Munirah - - 2013
Health professionals and researchers have become increasingly interested in biomarkers that help them in diagnosis of infections with recent growing attention to procalcitonin (PCT) and pro-adrenomedullin (proADM). This study compares proADM to PCT as diagnostic and prognostic biomarkers of infection in febrile patients with hematologic malignancies (HMs). From June 2009 ...
Pitre Chantalle A J - - 2013
Legionella pneumophila, an intracellular parasite of protozoa, possesses a distinct dimorphic life cycle that alternates between the vegetative replicative form and the resilient but highly infectious cyst form. Previously, temporally expressed heterodimeric IHF was shown to be required for differentiation into the cyst form. However, the precise regulatory mechanisms controlling ...
Farra Sharon - - 2013
The purpose of this study was to examine the effects of virtual reality simulation (VRS) on learning outcomes and retention of disaster training. The study used a longitudinal experimental design using two groups and repeated measures. A convenience sample of associate degree nursing students enrolled in a disaster course was ...
Sustaita Diego - - 2013
Human beings have been credited with unparalleled capabilities for digital prehension grasping. However, grasping behaviour is widespread among tetrapods. The propensity to grasp, and the anatomical characteristics that underlie it, appear in all of the major groups of tetrapods with the possible exception of terrestrial turtles. Although some features are ...
Gomez-Casati Diego F - - 2013
Glycosyltransferases (GTs) are a ubiquitous group of enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Nucleotide-sugars, lipid phosphate sugars and phosphate sugars can act as activated donor molecules while acceptor substrates involve carbohydrates, proteins, lipids, DNA and also, numerous ...
Ribeiro Grazielle Alves - - 2013
OBJECTIVES: The pterocarpanquinone LQB-118, previously demonstrated to be effective in vivo via oral delivery, was investigated for its mechanism in selective parasite killing. METHODS: Oxidative stress in Leishmania amazonensis was analysed by evaluating reactive oxygen species (ROS) production (2',7'-dichlorodihydrofluorescein diacetate) and the loss of mitochondrial membrane potential (ΔΨ(m)) using rhodamine, ...
Henna Elaine E Department of Psychiatry and Behavioral Sciences, University of Texas Center of Excellence on Mood Disorders, University of Texas-Houston Medical School, Houston, TX 77054, USA. - - 2013
  Impulsivity is increased in bipolar and unipolar disorders during episodes and is associated with substance abuse disorders and suicide risk. Impulsivity between episodes predisposes to relapses and poor therapeutic compliance. However, there is little information about impulsivity during euthymia in mood disorders. We sought to investigate trait impulsivity in ...
Uczaj Ukasz - - 2013
ABSTRACT: BACKGROUND: Dalmatia is an interesting place to study the use of wild greens as it lies at the intersection of influence of Slavs, who do not usually use many species of wild greens, and Mediterranean culinary culture, where the use of multiple wild greens is common. The aim of ...
Sadeghi Ali Asghar - - 2013
Abstract In the present study, electrophoretic deposition (EPD) was used to obtain dense layers of TiO¬2 in four organic media, methaol, ethanol, 1-propanol and butanol with different TiO2 nanoparticles concenteration of 1-8 (g/lit). Microstructural study of the obtained layers by scanning electron (SEM) and optical microscope (OM) revealed that the ...
Won Dahae - - 2013
Acute promyelocytic leukemia is characterized by the rearrangement of the retinoic acid receptor alpha (RARA) gene and its fusion with other genes. We report a novel case of variant acute promyelocytic leukemia with the karyotype der(2)t(2;17)(q32;q21). Array comparative genomic hybridization revealed distinct chromosome breakpoints within the RARA and oligonucleotide/oligosaccharide-binding fold ...
Singh Anup Kumar - - 2013
Glomus tumor is a rare predominantly benign soft tissue tumor. Lower respiratory tract is an uncommon site of origin of glomus tumor and hence endobronchial glomus tumor is extremely rare. This is mostly benign and identified incidentally on imaging. Diagnosis is confirmed by immunohistochemical staining and resection is the treatment ...
Neumann Sylvia - - 2013
A complete understanding of the molecular mechanisms governing vesicle formation requires quantitative assays and vesicle reconstitution using purified components. We describe a simple model membrane template for studying protein-mediated membrane remodeling and vesicle formation or fission that is amenable to both quantitative biochemical analysis and real-time imaging by epifluorescence microscopy. ...
Ní Chróinín Danielle D Neurovascular Unit for Applied Translational Research and Therapeutics, Mater University Hospital/Dublin Academic Medical Centre, University College Dublin, Ireland. - - 2013
Although experimental data suggest that statin therapy may improve neurological outcome after acute cerebral ischemia, the results from clinical studies are conflicting. We performed a systematic review and meta-analysis investigating the relationship between statin therapy and outcome after ischemic stroke. The primary analysis investigated statin therapy at stroke onset (prestroke ...
Cottrell Barbara A - - 2013
Natural organic matter (NOM) is ubiquitous and is one of the most complex naturally occurring mixtures. NOM plays an essential role in the global carbon cycle; atmospheric and natural water photochemistry; and the long-range transport of trace compounds and contaminants. There is a dearth of separation techniques capable of resolving ...
Tahrioui Ali - - 2013
A multisensory, hybrid histidine kinase (HK) and a response regulator (RR), which together may well constitute a two-component regulatory system (TCS), have been located in Halomonas anticariensis FP35T by transposon mutagenesis. This TCS is homologous to the GacS/GacA described in many Gram-negative bacteria. An analysis of crude N-acyl homoserine lactone ...
Mok Ka-Wai KW Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, 1230 York Ave, New York, NY 10065, - - 2013
In the mammalian testis, coexisting tight junctions (TJs), basal ectoplasmic specializations, and gap junctions (GJs), together with desmosomes near the basement membrane, constitute the blood-testis barrier (BTB). The most notable feature of the BTB, however, is the extensive network of actin filament bundles, which makes it one of the tightest ...
González-Gugel Elena E Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, - - 2013
Inappropriate activation of the GLI/hedgehog (GLI/Hh) signalling occurs in several human cancers, including haematological neoplasms. However, little is known about its relevance in precursor T-cell lymphoblastic lymphomas (T-LBL) development. Moreover, the mechanisms whereby GLI/Hh signalling is activated in haematological malignancies are not fully clear. Here, we show that the gene ...
Larkin Sarah Jane - - 2013
ObjectiveSomatotroph adenomas causing acromegaly are histologically classified into densely and sparsely granulated subtypes with different morphology, clinical characteristics and treatment outcomes. Granulation pattern has been reported to co-segregate with a recurrent mutation at codon 49 in growth hormone receptor (GHR) and GSP oncogene. This study examines response to the octreotide ...
Shen Fang-Hsiu - - 2013
Enterovirus 71 (EV71) infection has induced fatal encephalitis in thousands of young children in the Asia-Pacific region since the last decade. EV71 infection continues to cause serious problems in areas with outbreaks, because vaccines and antiviral therapies are not available. Lymphocytes are present in brains of infected patients and mice ...
Napoli Eleonora E Department of Molecular Biosciences, University of California, Davis, CA, - - 2013
Polybrominated diphenyl ethers (PBDEs) represent an important group of flame retardants extensively used, tonnage of which in the environment has been steadily increasing over the past 25 years. PBDEs or metabolites can induce neurotoxicity and mitochondrial dysfunction (MD) through a variety of mechanisms. Recently, PBDEs with < 5 Br substitutions ...
Anblagan Devasuda - - 2013
Objectives We have developed and assessed the reliability of magnetic resonance (MR) imaging techniques to measure fetal fat volume in utero. We studied fetal growth in women with and without diabetes in view of the increased prevalence of macrosomia in the former. Methods We studied 26 pregnant women, 14 with ...
Santoro A A Medical Oncology and Hematology Unit, Humanitas Cancer Center, Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano (Milan), - - 2013
The mesenchymal-epithelial transition factor (MET) receptor is dysregulated in hepatocellular carcinoma (HCC), and tivantinib (ARQ 197) is an oral, selective, MET inhibitor. This Phase-1b study assessed tivantinib safety as primary objective in patients with previously treated HCC and Child-Pugh A or B liver cirrhosis. Patients received oral tivantinib 360 mg ...
Terry Jefferson - - 2013
Abstract Aortico-left ventricular tunnel (ALVT) is a rare congenital heart anomaly of unclear pathogenesis causing left ventricular volume overload. Most descriptions are from surgical corrections in the neonatal and infantile period and little is known about ALVT in utero. Here we describe a case of ALVT ending in intrauterine demise ...
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