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De Marcos Lousa Carine C Centre for Plant Sciences, School of Biology, University of Leeds, Leeds LS2 9JT, United - - 2013
Peroxisomes are organelles that perform diverse metabolic functions in different organisms, but a common function is β-oxidation of a variety of long chain aliphatic, branched, and aromatic carboxylic acids. Import of substrates into peroxisomes for β-oxidation is mediated by ATP binding cassette (ABC) transporter proteins of subfamily D, which includes ...
Agirre Jon - - 2013
Triatoma Virus (TrV) is a member of the insect virus family Dicistroviridae and consists of a small, non-enveloped capsid that encloses its +ssRNA genome. Using cryo-TEM and 3D reconstruction techniques combined with the fitting of the available crystallographic models, we analyzed the capsids corresponding to mature and several RNA-empty TrV ...
Calahorro A J - - 2013
We report the synthesis of a novel ligand, 3,3'-(1,2,4,5-tetrazine-3,6-diyl)dibenzoic acid (1). In this fragment, we have introduced two carboxylate groups with the aim of using this ligand as a linker to construct three-dimensional metal-organic frameworks (MOFs). We have been successful in the formation of zinc (2) and lanthanum (3) MOFs. ...
Lhenry Sebastien - - 2013
The use of a chemically irreversible redox probe in Scanning Electrochemical Microscopy (SECM) was evaluated for the determination of the absolute tip-substrate distance. This data is required for a quantitative use of the method in the analysis of functional surfaces with an unknown redox response. Associated with the relevant model ...
Kim Sirim - - 2013
Using the concept of isomorphous replacement applied to entire ligands, a C3-symmetric trisulfonate ligand was substituted with a C3-symmetric tris(hydrogen phosphonate) ligand in a proton conducting MOF. The resulting material, PCMOF2.5, has its proton conduction raised 1.5 orders of magnitude, to 2.1x10-2Scm-1 at 90% relative humidity and 85C, while maintaining ...
Azzolini Catia - - 2013
U937 cells exposed to physiological concentrations of ascorbic acid (AA) accumulate the reduced form of the vitamin in the cytosol and even further in their mitochondria. In both circumstances, uptake was dependent on Na(+) -AA-cotransport, with hardly any contribution of hexose transporters, which might be recruited to transport the oxidized ...
Lundsgaard-Hansen B - - 2013
Parallel phenotypic divergence in replicated adaptive radiations could either result from parallel genetic divergence in response to similar divergent selection regimes or from equivalent phenotypically plastic response to the repeated occurrence of contrasting environments. In post-glacial fish, replicated divergence in phenotypes along the benthic-limnetic habitat axis is commonly observed. Here, ...
Peng Jen-Kuei - - 2013
OBJECTIVE: Community physicians have a vital role in delivering palliative care, yet their willingness and factors that influence its provision have rarely been explored. Our aims were to identify the willingness of community physicians to provide palliative care for patients with terminal cancer and to investigate the factors that influence ...
Derveni Mariliza - - 2013
Abstract The Life Marker Chip (LMC) instrument is an immunoassay-based sensor that will attempt to detect signatures of life in the subsurface of Mars. The molecular reagents at the core of the LMC have no heritage of interplanetary mission use; therefore, the design of such an instrument must take into ...
Michen Benjamin - - 2013
Ceramic filters, working on the depth filtration principle, are known to improve drinking water quality by removing human pathogenic microorganisms from contaminated water. However, these microfilters show no sufficient barrier for viruses having diameters down to 20 nm. Recently, it was shown that the addition of positively charged materials, for ...
Ma Zhiyuan - - 2013
Many psychotropic substances used either for medications or illicit recreational purposes are able to produce an increase in extracellular serotonin (5HT) in the CNS. 5HT is well known to improve mood, however, only when the levels of its release are in an appropriate range. Excessive 5HT is harmful, and will ...
Le Binh V BV Department of Chemistry, Yale University, New Haven, Connecticut 06520-81070, - - 2013
Male Anopheles mosquitoes coagulate their seminal fluids via cross-linking of a substrate, called Plugin, by the seminal transglutaminase AgTG3. Formation of the "mating plug" by cross-linking Plugin is necessary for efficient sperm storage by females. AgTG3 has a similar degree of sequence identity (~30%) to both human Factor XIII (FXIII) ...
Ben-Yona Assaf A From the Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel-Canada, Hebrew University Hadassah Medical School, Jerusalem 91120, - - 2013
The GABA transporter GAT-1 belongs to the neurotransmitter:sodium:symporters which are crucial for synaptic transmission. GAT-1 mediates electrogenic transport of GABA together with sodium and chloride. Structure-function studies indicate that the bacterial homologue LeuT, which possess extra- and intracellular thin gates, is an excellent model for this class of neurotransmitter transporters. ...
Falmbigl M - - 2013
Phase relations and solidification behavior in the Ge-rich part of the phase diagram have been determined in two isothermal sections at 700 and 750 °C and in a liquidus projection. A reaction scheme has been derived in the form of a Schulz-Scheil diagram. Phase equilibria are characterized by three ternary ...
Estrella Veronica V Departments of Cancer Imaging and Metabolism, Radiology, and Analytic Microscopy Laboratory, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, - - 2013
The pH of solid tumors is acidic due to increased fermentative metabolism and poor perfusion. It has been hypothesized that acid pH promotes local invasive growth and metastasis. The hypothesis that acid mediates invasion proposes that H(+) diffuses from the proximal tumor microenvironment into adjacent normal tissues where it causes ...
Swanson J R - - 2013
Objective:Assess the attitudes and perceptions of parents and healthcare providers regarding the neonatal intensive care unit (NICU) environment while transitioning from an open ward (OW) to private-room (PR) NICU.Study Design:Parents and staff were surveyed 6 months before and 1 and 8 months after moving from OW to PR in a ...
Echalier Aude - - 2013
The COP9 (Constitutive photomorphogenesis 9) signalosome (CSN), a large multiprotein complex that resembles the 19S lid of the 26S proteasome, plays a central role in the regulation of the E3-cullin RING ubiquitin ligases (CRLs). The catalytic activity of the CSN complex, carried by subunit 5 (CSN5/Jab1), resides in the deneddylation ...
Motte Hans - - 2013
In vitro shoot regeneration is implemented in basic plant research and commercial plant production, but for some plant species still difficult to achieve by means of the currently available cytokinins and auxins. To identify novel compounds that promote shoot regeneration, we screened a library of 10,000 small molecules. The bioassay ...
Zhang Yuxin - - 2013
BM2 channel plays an important role in the replication of influenza virus B. However, few studies attempt to investigate the mechanism of the proton conductance in BM2 channel, as well as the drug-resistance of BM2 channel. The first experimental structure of BM2 protein channel has recently been solved, enabling us ...
Zhang Yiying - - 2013
In order to improve stress transfer between polymer matrices and nano-fillers, controlling the structure development in the interphase region during composite processing is a necessity. For polyacrylonitrile (PAN)/single-wall carbon nanotubes (SWNT) composites, the formation of the PAN interphase in the presence of the SWNT as a function of processing conditions ...
Malassis Ludivine - - 2013
In an attempt to fabricate low index metamaterials by a bottom-up approach, meta-atoms constituted of silica coated silver nanoparticles are assembled by a Langmuir-Schaefer technique into thin films of large area and well controlled thickness. The silica shells insure a constant distance between the silver cores, hence providing a constant ...
Gao Chong C Department of Pathology, Joint Program in Transfusion Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, - - 2013
An exciting recent approach to targeting transcription factors in cancer is to block formation of oncogenic complexes. We investigated whether interfering with the interaction of the transcription factor SALL4, which is critical for leukemic cell survival, and its epigenetic partner complex represents a novel therapeutic approach. The mechanism of SALL4 ...
Lan Chou-Chin - - 2013
Background:Pulmonary rehabilitation (PR) is beneficial for patients with chronic obstructive pulmonary disease (COPD) with improvement in exercise capacity, healthy-related quality of life (HRQL). Despite these overall benefits, the responses to PR vary significantly among different individuals. It is not clear if PR is beneficial for patients with COPD with normal ...
Maslov A V - - 2013
We analyze the response of a metallic ring to an applied time-harmonic and spatially uniform magnetic field. The self-consistent current distribution and magnetic moment are compared with that from an equivalent LR circuit model and the range of parameters (size, frequency and conductivity) for the model applicability is analyzed. The ...
Velkey J M - - 2013
BACKGROUND: Delineating the cascades of growth and transcription factor expression that shape the developing nervous system will improve our understanding of its molecular histogenesis and suggest strategies for cell replacement therapies. In the current investigation, we examined the ability of the proneural gene, Neurogenin1 (Neurog1; also Ngn1, Neurod3), to drive ...
Manawadu Dulka - - 2013
BACKGROUND AND PURPOSE: Wake-up ischemic stroke (WUIS) patients are not eligible for thrombolysis; the a priori hypothesis was that thrombolysis of selected WUIS patients who meet clinical and imaging criteria for treatment is associated with better outcomes. METHODS: The sample consisted of consecutive WUIS patients who fulfilled predefined criteria: (1) ...
Periasamy Prakash - - 2013
A systematic study of the role of insulator layer on rectification performance in metal-insulator-metal structures is reported. Four different MIM systems with Nb/Pt metal pairs and Nb(2) O(5) , TiO(2) , Al(2) O(3) , MgO as the insulator candidates are investigated based on an empirical hypothesis. As per the hypothesis ...
Riha Shannon C - - 2013
High specific surface area transparent and conducting frameworks, fabricated by atomic layer deposition (ALD), were used as scaffolds for fabrication of equally high area, ALD-formed hematite structures for photo-oxidation of water to dioxygen. The frameworks offer high transparency to visible light and robust conductivity under harsh annealing and oxidizing conditions. ...
Harinantenaina Liva L Department of Chemistry and Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg, Virginia 24061, - - 2013
Bioassay-guided fractionation of an ethanol extract of the leaves and inflorescence of Mallotus oppositifolius collected in Madagascar led to the isolation of the two new bioactive dimeric phloroglucinols mallotojaponins B (1) and C (2), together with the known mallotophenone (3). The structures of the new compounds were determined on the ...
Watabe Tadashi - - 2013
PET with (15)O gas has been used for the quantitative measurement of cerebral blood flow (CBF), cerebral metabolic rate of oxygen (CMRO(2)), oxygen extraction fraction (OEF), and cerebral blood volume (CBV) in humans. However, several technical difficulties limit its use in experiments on small animals. Herein, we describe the application ...
Malloy M H - - 2013
Objective:In 1987, the sudden infant death syndrome (SIDS) rate in the United States was 1.2 per 1000 live births. By the year 2005, the SIDS rate had dropped more than half to approximately 0.5 per 1000 live births. In 1987, the risk of SIDS was 2.32 times greater for extremely ...
Xin Xiaoqing - - 2013
A facile and efficient synthetic route to multi-substituted 2-aminopyridines has been developed via a formal [5C + 1N] annulation of readily available 2,4-pentadienenitriles with hydroxylamine (NH(2)OH) under very mild conditions, which involves sequential intermolecular aza-nucleophilic addition of hydroxylamine, intramolecular aza-cyclization, and dehydration reactions.
Lin Jing-Yi - - 2013
ABSTRACT: BACKGROUND: Epicutaneous sensitization with protein allergen that induces predominant Th2 responses is an important sensitization route in atopic dermatitis. Fungal components have been shown to modulate Th cell differentiation. However, the effects of fungal components on epicutaneous sensitization are unclear. RESULTS: In this study, we showed that co-administration of ...
Wyshak Grace - - 2013
AIMS: In the US, higher SES (socio-economic status) groups and white Americans tend to be "healthier" than less advantaged groups. Elimination of disparities is a major public health goal. This study examines disparities for two highly prevalent medical conditions - depression and chronic back pain - and selected medical conditions ...
Zarea Mahdi - - 2013
We study quantum interference effects in a 4-level system which can be used as a minimal model to understand such behavior in systems from synthetic molecular structures to the photosystem-1 reaction center. The effects of environmental decoherence and relaxation on the electron transfer rate are investigated for several types of ...
Petrisic Marinka Gams - - 2013
A combination of molecular and stable isotope analyses was used to trace and identify the sources of polycyclic aromatic hydrocarbons (PAH) in sediments of Lake Bled (NW Slovenia). Sediment samples were taken from two locations with contrasting depositional regimes: Zaka Bay, with permanently oxic bottom and station D, where anoxic ...
Ghobrial Irene M IM Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. - - 2013
The present study aimed to determine the safety and activity of the histone deacetylase inhibitor panobinostat in patients with relapsed/refractory Waldenström macroglobulinemia (WM). Eligibility criteria included patients with relapsed/refractory WM with any number of prior therapies. Patients received panobinostat at 30 mg 3 times a week; 12 of 36 (33%) ...
Galeote Miguel - - 2013
ABSTRACT The objective of this work was to analyze morphosyntactic development in a wide sample of children with Down syndrome (DS) (n = 92) and children with typical development (TD) (n = 92) with a mental age (MA) of 20 to 29 months. Children were individually matched for gender and MA (Analysis 1) and ...
Galkina Svetlana I SI Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia. - - 2013
In this review, we summarized data on the formation and structure of the long and highly adhesive membrane tubulovesicular extensions (TVEs, membrane tethers or cytonemes) observed in human neutrophils and other mammalian cells, protozoan parasites and bacteria. We determined that TVEs are membrane protrusions characterized by a uniform diameter (130-250 ...
Chang Alex C Y - - 2013
OBJECTIVE: We have recently described that Notch activates nitric oxide (NO) signaling in the embryonic endocardium. Both Notch signaling and NO signaling have been shown to be important during adult arteriogenesis. Notch has been shown to be required for remodeling of the collateral vessels, whereas NO is required for the ...
Markhus C E - - 2013
The pathophysiology of lymphedema is incompletely understood. We asked how transcapillary fluid balance parameters and lymph flow are affected in a transgenic mouse model of primary lymphedema, which due to an inhibition of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling lacks dermal lymphatics, and whether protein accumulation in the interstitium ...
Olivares Isabel - - 2013
ABSTRACT Human immunodeficiency virus type 1 (HIV-1) persistently infected cell lines are characterized by the continuous viral production without cytopathic effect. However, it is not completely clear if this production is contributed only by viral transcription or also by new cycles of viral replication. We studied an HIV-1 persistently infected ...
Chen Yuncong - - 2013
Quick: An exogenously induced quick increase of the H(2) S concentration (80 s) in MCF-7 cells can be visualized by ratiometric imaging using a new probe (CouMC) that can target mitochondria. CouMC was constructed by combining merocyanine and coumarin fluorophores. The selective nucleophilic addition of HS(-) to the merocyanine derivative ...
Löwenberg Bob - - 2013
High-dose cytarabine applied during remission induction or as consolidation after attainment of a complete remission has become an established element in the treatment of adults with acute myeloid leukemia. Recent evidence has challenged the need for these exceptionally high-dose levels of cytarabine. In this review, we present a reappraisal of ...
Koch Christin - - 2013
Functions of complex natural microbial communities are realized by single cells that contribute differently to the overall performance of a community. Usually, molecular and, more recently, deep-sequencing techniques are used for detailed but resource-consuming phylogenetic or functional analyses of microbial communities. Here we present a method for analyzing dynamic community ...
Kuboki S - - 2013
BACKGROUND: Postoperative chylous ascites following abdominal surgery is uncommon. It potentially induces malnutrition and immunodeficiency, contributing to increased mortality. In the field of hepatopancreatobiliary (HPB) surgery, no large studies have been conducted that focused on postoperative chylous ascites. The aim of this study was to determine the incidence, risk factors ...
Puente-Maestu Luis - - 2013
Mitochondrial muscle alterations are common in patients with chronic obstructive pulmonary disease (COPD) and manifest mainly as decreased oxidative capacity and excessive production of reactive oxygen species (ROS). The significant loss of oxidative capacity observed in the quadriceps of COPD patients is mainly due to reduced mitochondrial content in the ...
Bender Welcome W Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, - - 2013
The bithorax complex in Drosophila melanogaster includes three homeobox-containing genes--Ultrabithorax (Ubx), abdominal--A (abd-A), and Abdominal-B (Abd-B)-which are required for the proper differentiation of the posterior 10 segments of the body. Each of these genes has multiple distinct regulatory regions; there is one for each segmental unit of the body plan ...
Wang Jen-Yu - - 2013
OBJECTIVE: Most of the existing findings on the association between diabetes mellitus and colorectal cancer were generated from studies in Western societies. However, significant differences in cancer incidence and cancer-prone lifestyles are apparent between Asian and Western countries. This study aims to estimate the risks of colorectal cancer in the ...
Westein Erik - - 2013
Rupture of a vulnerable atherosclerotic plaque causes thrombus formation and precipitates cardiovascular diseases. In addition to the thrombogenic content of a plaque, also the hemodynamic microenvironment plays a major role in thrombus formation. How the altered hemodynamics around a plaque promote pathological thrombus formation is not well understood. In this ...
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