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Results 501 - 550 of 2749
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Pessach Ilias - - 2013
BACKGROUNDHematopoietic growth factors (HGFs) are mostly used as supportive measures to reduce infectious complications associated with neutropenia. Over the past decade, the use of HGFs became a common method for mobilizing human CD34+ stem cells, either for autologous or allogeneic transplantation. However, since their introduction the long-term safety of the ...
Yu Dong-Jun - - 2013
Understanding the interactions between proteins and ligands is critical for protein function annotations and drug discovery. We report a new sequence-based template-free predictor (TargetATPsite) to identify the Adenosine-5'-triphosphate (ATP) binding sites with machine-learning approaches. Two steps are implemented in TargetATPsite: binding residues and pockets predictions, respectively. To predict the binding ...
Ko Y J - - 2013
INTRODUCTION: Immature platelet fraction (IPF) is a parameter for reticulated platelets. A high percentage IPF (%-IPF) is indicative of consumptive or recovering thrombocytopenic disorders in contrast to a low %-IPF seen in aplastic states. Absolute IPF (A-IPF) specifically reflects the number of immature platelets in circulation. This study aimed to ...
Rosen Jeffrey B - - 2013
The low-density lipoprotein cholesterol (LDL-C) lowering efficacy of switching to ezetimibe/simvastatin (EZ/S) 10/20 mg versus doubling the run-in statin dose (to simvastatin 40 mg or atorvastatin 20 mg) or switching to rosuvastatin 10 mg in subjects with cardiovascular disease (CVD) and diabetes was assessed. Endpoints included percentage change in LDL-C ...
Deng Guo-Bo - - 2013
Ray of light: 10a,11-dihydro-10H-benzo[b]fluorenes were synthesized by a visible-light catalyzed tandem cyclization of 1,6-enynes with arylsulfonyl chlorides. This method extends the scope of enyne cyclizations and represents a new synthetic application of arylsulfonyl chlorides.
Schenk Christian - - 2013
Similar yet different: The reaction of a GeBr solution with K[FeCp(CO)(2) ] (Cp=η-C(5) H(5) ) gives [Ge(12) {FeCp(CO)(2) }(8) {FeCp(CO)}(2) ] (1), whose oblong, highly cross-linked cluster core reveals a cut-out of the high-pressure solid-state structure of germanium (II). Mass spectrometric investigations on the gas-phase species [Ge(6) {FeCp(CO)(2) }(6) {FeCp(CO)}](-) ...
Ascenzi Paolo - - 2013
Summary: Ligand binding to the heme distal side is a paradigm of biochemistry. However, X-ray crystallographic studies highlighted the possibility that O(2) and NO(2) (-) may bind to the proximal heme side of ferrous human hemoglobin (Hb) α-chains complexed with the α-hemoglobin stabilizing protein and to ferric human hemoglobin β-chains, ...
Watabe Tadashi - - 2013
PET with (15)O gas has been used for the quantitative measurement of cerebral blood flow (CBF), cerebral metabolic rate of oxygen (CMRO(2)), oxygen extraction fraction (OEF), and cerebral blood volume (CBV) in humans. However, several technical difficulties limit its use in experiments on small animals. Herein, we describe the application ...
Malloy M H - - 2013
Objective:In 1987, the sudden infant death syndrome (SIDS) rate in the United States was 1.2 per 1000 live births. By the year 2005, the SIDS rate had dropped more than half to approximately 0.5 per 1000 live births. In 1987, the risk of SIDS was 2.32 times greater for extremely ...
Xin Xiaoqing - - 2013
A facile and efficient synthetic route to multi-substituted 2-aminopyridines has been developed via a formal [5C + 1N] annulation of readily available 2,4-pentadienenitriles with hydroxylamine (NH(2)OH) under very mild conditions, which involves sequential intermolecular aza-nucleophilic addition of hydroxylamine, intramolecular aza-cyclization, and dehydration reactions.
Lin Jing-Yi - - 2013
ABSTRACT: BACKGROUND: Epicutaneous sensitization with protein allergen that induces predominant Th2 responses is an important sensitization route in atopic dermatitis. Fungal components have been shown to modulate Th cell differentiation. However, the effects of fungal components on epicutaneous sensitization are unclear. RESULTS: In this study, we showed that co-administration of ...
Wyshak Grace - - 2013
AIMS: In the US, higher SES (socio-economic status) groups and white Americans tend to be "healthier" than less advantaged groups. Elimination of disparities is a major public health goal. This study examines disparities for two highly prevalent medical conditions - depression and chronic back pain - and selected medical conditions ...
Zarea Mahdi - - 2013
We study quantum interference effects in a 4-level system which can be used as a minimal model to understand such behavior in systems from synthetic molecular structures to the photosystem-1 reaction center. The effects of environmental decoherence and relaxation on the electron transfer rate are investigated for several types of ...
Petrisic Marinka Gams - - 2013
A combination of molecular and stable isotope analyses was used to trace and identify the sources of polycyclic aromatic hydrocarbons (PAH) in sediments of Lake Bled (NW Slovenia). Sediment samples were taken from two locations with contrasting depositional regimes: Zaka Bay, with permanently oxic bottom and station D, where anoxic ...
Kim Jin Seok - - 2013
The type III secretion systems (T3SSs) are exploited by many Gram-negative pathogenic bacteria to deliver a set of effector proteins into host cytosol during cell entry. The T3SS of Salmonella enterica serovar Typhimurium is composed of more than 20 proteins that constitute the membrane-associated base, needle and the tip complex ...
Llurba Elisa - - 2013
Objective: To examine relationships between umbilical and internal carotid artery Doppler findings and cognitive development at 3 and 6 years in small for gestational age (SGA) children. Methods: SGA children (birthweight <10(th) centile) born after 28 weeks' with umbilical artery (UA) resistance index (RI) measured within 2 weeks of delivery. ...
Rintala Tuula-Maria - - 2013
Diabetes mellitus is a common chronic disease all over the world. Self-management plays a crucial role in diabetes management. The purpose of this systematic review was to summarize what is known about the interactions between adult persons with diabetes, their family, and diabetes self-management. MEDLINE, CINAHL, PSYCHINFO, LINDA, and MEDIC ...
Zong Zhiyong - - 2013
OBJECTIVES: This study screened hospital sewage for the presence of bla(NDM). METHODS: Colonies grown from plates containing meropenem streaked with hospital sewage were screened for bla(NDM) by PCR. Species identification was performed by sequencing 16S rRNA genes. Clonal relatedness of isolates was determined by Enterobacterial repetitive intergenic consensus sequence-PCR, sequencing ...
E Qiukai - - 2013
It has been reported that over-expression of GRP75 can protect cells under different types of stress. In this study, we investigated the protective effect of GRP75 on the liver both in vivo and in vitro. To evaluate the effect of GRP75 over-expression on oxidative damage in the liver in vitro, ...
Dellweg Dominic - - 2013
Background:Oxygen therapy is usually combined with a humidification device to prevent mucosal dryness. Depending of the cannula design oxygen can be administered pre- or intra-nasally (administration of oxygen in front of the nasal ostia versus cannula system inside the nasal vestibulum). The impact of the cannula design on intra-nasal humidity ...
Sutherland Jennifer - - 2013
In 2003, the UK Food Standards Agency and the Department of Health began attempts to reduce national salt intakes via reformulation of processed foods and a consumer awareness campaign on the negative impacts of salt on health. The present study uses large nationally representative samples of households in England to ...
Neumann Sylvia - - 2013
A complete understanding of the molecular mechanisms governing vesicle formation requires quantitative assays and vesicle reconstitution using purified components. We describe a simple model membrane template for studying protein-mediated membrane remodeling and vesicle formation or fission that is amenable to both quantitative biochemical analysis and real-time imaging by epifluorescence microscopy. ...
Cottrell Barbara A - - 2013
Natural organic matter (NOM) is ubiquitous and is one of the most complex naturally occurring mixtures. NOM plays an essential role in the global carbon cycle; atmospheric and natural water photochemistry; and the long-range transport of trace compounds and contaminants. There is a dearth of separation techniques capable of resolving ...
Tahrioui Ali - - 2013
A multisensory, hybrid histidine kinase (HK) and a response regulator (RR), which together may well constitute a two-component regulatory system (TCS), have been located in Halomonas anticariensis FP35T by transposon mutagenesis. This TCS is homologous to the GacS/GacA described in many Gram-negative bacteria. An analysis of crude N-acyl homoserine lactone ...
Larkin Sarah Jane - - 2013
ObjectiveSomatotroph adenomas causing acromegaly are histologically classified into densely and sparsely granulated subtypes with different morphology, clinical characteristics and treatment outcomes. Granulation pattern has been reported to co-segregate with a recurrent mutation at codon 49 in growth hormone receptor (GHR) and GSP oncogene. This study examines response to the octreotide ...
Shen Fang-Hsiu - - 2013
Enterovirus 71 (EV71) infection has induced fatal encephalitis in thousands of young children in the Asia-Pacific region since the last decade. EV71 infection continues to cause serious problems in areas with outbreaks, because vaccines and antiviral therapies are not available. Lymphocytes are present in brains of infected patients and mice ...
Anblagan Devasuda - - 2013
Objectives We have developed and assessed the reliability of magnetic resonance (MR) imaging techniques to measure fetal fat volume in utero. We studied fetal growth in women with and without diabetes in view of the increased prevalence of macrosomia in the former. Methods We studied 26 pregnant women, 14 with ...
Terry Jefferson - - 2013
Abstract Aortico-left ventricular tunnel (ALVT) is a rare congenital heart anomaly of unclear pathogenesis causing left ventricular volume overload. Most descriptions are from surgical corrections in the neonatal and infantile period and little is known about ALVT in utero. Here we describe a case of ALVT ending in intrauterine demise ...
Chambers John R - - 2013
In three studies, we tested whether prejudice derives from perceived similarities and dissimilarities in political ideologies (the value-conflict hypothesis). Across three diverse samples in Study 1, conservatives had less favorable impressions than liberals of groups that were identified as liberal (e.g., African Americans, homosexuals), but more favorable impressions than liberals ...
Bekelis K - - 2013
BACKGROUND: There is significant variation in the indications for intervention in patients with recurrent carotid artery stenosis. The aim of the present study was to describe these indications in a contemporary cohort of patients. METHODS: This was a systematic review of all peer-reviewed studies reporting on the indications for carotid ...
Zhou Bingwei - - 2013
The first manganese-catalyzed aromatic C-H alkenylation with terminal alkynes is described. The procedure features an operationally simple catalyst system containing commercially available MnBr(CO)5 and dicyclohexylamine (Cy2NH). The reaction occurs readily in a highly chemo-, regio-, and stereoselective manner delivering anti-Markovnikov E-configured olefins in high yields. Experimental study and DFT calculations ...
Sneitz Nina - - 2013
The glucuronidation of estriol, 16-epiestriol and 17-epiestriol by the human UDP-glucuronosyltransferases (UGTs) of subfamilies 1A, 2A and 2B was examined. UGT1A10 is highly active in the conjugation of the 3-OH in all these estriols, whereas UGT2B7 is the most active UGT toward one of the ring D hydroxyls, the 16-OH ...
De Bellis Annamaria - - 2013
Background: Pituitary and thyroid autoimmunity can be triggered by pregnancy. We report the first association of combined growth hormone (GH) and prolactin secretion deficiency due to autoimmune damage to GH- and prolactin- secreting cells in a patient with post delivery lactational failure, presenting subsequently with primary autoimmune hypothyroidism. Patient Findings: ...
Qin Changming - - 2013
The rhodium-catalyzed reaction of 2-diazo-5-arylpent-4-enoates can be controlled by the appropriate choice of catalyst and catalyst loading to form either 2-arylbicyclo[1.1.0]butane carboxylates or cyclohexene derivatives. Both products are produced in a highly diastereoselective manner, with 2-arylbicyclo[1.1.0]butane carboxylates preferentially formed under low catalyst loadings. When the reaction is catalyzed by Rh(2)(R-BTPCP)(4), ...
Grinsted L - - 2013
Reproductive partitioning is a key component of social organization in groups of cooperative organisms. In colonies of permanently social spiders of the genus Stegodyphus less than half of the females reproduce, while all females, including nonreproducers, perform suicidal allo-maternal care. Some theoretical models suggest that reproductive skew is a result ...
Li Wenyang - - 2013
Background:A systematic review and meta-analysis was performed to compare the outcomes of oral appliances (OA) with those of continuous positive airway pressure (CPAP) in treatment of patients with obstructive sleep apnea (OSA).Methods:Relevant studies were retrieved from the following electronic databases up to and including Semptember 2012: MEDLINE, PubMed, EMBASE, and ...
Liberato Michelle S - - 2013
We report for the first time on the self-assembly of nanostructures composed exclusively of alternating positively charged and hydrophobic amino acids. A novel arginine/phenylalanine octapeptide, RF8, was synthesized. Because the low hydrophobicity of this sequence makes its spontaneous ordering through solution-based methods difficult, a recently proposed solid-vapor approach was used ...
Patel Mitul K - - 2013
Phosphate esters in polyhydroxylated systems are normally blighted by uncontrolled migration under a variety of reaction conditions. Cesium fluoride is demonstrated as a reagent to control migration of primary phosphates during transesterifications. This allows easy exchange of phosphoryl protecting groups enabling enhanced synthetic strategic flexibility and regioselective phosphate installation. Mechanistic ...
Lipkin W Ian - - 2013
The pace of pathogen discovery is rapidly accelerating. This reflects not only factors that enable the appearance and globalization of new microbial infections, but also improvements in methods for ascertaining the cause of a new disease. Innovative molecular diagnostic platforms, investments in pathogen surveillance (in wildlife, domestic animals and humans) ...
Núñez Ivanna Novotny - - 2013
Protein-energy malnutrition (PEM) causes a significant impairment of the immune system, the thymus being one of the most affected organs. It has been demonstrated that the administration of probiotic fermented milk (PFM) recovered the intestinal barrier, histological alterations and mucosal and systemic immune functions in a non-severe malnutrition model using ...
Jadidi-Niaragh Farhad - - 2013
Little is known regarding the immunobiology of regulatory T (Treg) cells in hematopoietic malignancies, particularly in chronic lymphocytic leukemia (CLL). In the present study, we showed that the frequencies of CD8(+) and CD4(+) Treg cells were significantly increased in progressive as compared with indolent CLL patients and normal subjects. Enriched ...
Haugarvoll Kristoffer - - 2013
ABSTRACT: BACKGROUND: Correct diagnosis is pivotal to understand and treat neurological disease. Herein, we report the diagnostic work-up utilizing exome sequencing and the characterization of clinical features and brain MRI in two siblings with a complex, adult-onset phenotype; including peripheral neuropathy, epilepsy, relapsing encephalopathy, bilateral thalamic lesions, type 2 diabetes ...
Menendez Laura - - 2013
Multipotent neural crest stem cells (NCSCs) have the potential to generate a wide range of cell types including melanocytes; peripheral neurons; and smooth muscle, bone, cartilage and fat cells. This protocol describes in detail how to perform a highly efficient, lineage-specific differentiation of human pluripotent cells to a NCSC fate. ...
Prota Andrea E - - 2013
Microtubule-stabilizing agents (MSAs) are efficacious chemotherapeutic drugs widely used for the treatment of cancer. Despite the importance of MSAs for medical applications and basic research, their molecular mechanisms of action on tubulin and microtubules remain elusive. Here, we determined high-resolution crystal structures of αβ-tubulin in complex with two unrelated MSAs, ...
Tweedy Brent - - 2013
We examined the effects of fish predation on emergent insect-mediated methyl mercury (MeHg) flux across a gradient of MeHg contamination in experimental ponds. Emergent insects were collected from ponds with (n=5) and without fish (n=5) over a six-week period using floating emergence traps. We found that the potential for MeHg ...
Castro-Rodriguez Jose A - - 2013
Objective. The aim of this post hoc analysis was to establish the relationship between FE(NO) levels and the asthma predictive index (API) among infants with recurrent wheezing. Methods. Infants with recurrent wheezing (three or more episodes) were recruited consecutively and online FE(NO) tests at tidal breathing with multiple breaths were ...
Hunter Rebecca A - - 2013
Despite growing reports on the biological action of nitric oxide (NO) as a function of NO payload, the validity of such work is often questionable due to the manner in which NO is measured and/or the solution composition in which NO is quantified. To highlight the importance of measurement technique ...
Ozsu Savas - - 2013
BACKGROUND AND OBJECTIVE: Pentraxin-3 (PTX-3) is a relatively new marker of inflammation which has not been previously tested (PPEs) and whether it discriminates complicated from uncomplicated in pleural effusions. We aimed to assess whether PTX-3 is an accurate biomarker of parapneumonic effusions PPEs. METHODS: The concentrations of pleural fluid PTX-3 ...
Steigenberger Barbara - - 2013
The synthesis of the triphosphates of 5-hydroxymethyl-, 5-formyl-, and 5-carboxycytidine and the incorporation of these building blocks into long DNA fragments using the polymerase chain reaction (PCR) are reported. In this way DNA fragments containing multiple hmC, fC, and caC nucleobases are readily accessible.
García-Ojeda Marcos E - - 2013
Transcription factors orchestrate T-lineage differentiation in the thymus. One critical checkpoint involves Notch1 signaling that instructs T-cell commitment at the expense of the B-lineage program. While GATA-3 is required for T cell specification, its mechanism of action is poorly understood. Here we show that GATA-3 works in concert with Notch1 ...
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