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Results 501 - 550 of 2749
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Kronström Kim - - 2013
Background: The personality variables optimism and pessimism are potential risk factors for disorders commonly treated with antidepressants. Aims: To evaluate optimism and pessimism as predictors of initiating and ending an antidepressant treatment. Methods: Data consisted of 29,930 public sector employees with no record of diagnosed depression. Optimism and pessimism were ...
Torricelli Franck - - 2013
Pick and choose: Novel cationic diaza-, azaoxo-, and dioxo[6]helicenes are readily prepared and functionalized selectively by orthogonal aromatic electrophilic and vicarious nucleophilic substitutions. Reductions, cross-coupling, or condensation reactions introduce additional diversity and allow tuning of the absorption properties up to the near-infrared region. The diaza salts can be resolved into ...
Dixon K M KM Department of Pathology, School of Medical Sciences, Sydney Medical School, The University of Sydney, Sydney, New South Wales 2006, - - 2013
Effective treatment of prostate cancer should be based on targeting interactions between tumour cell signalling pathways and key converging downstream effectors. Here, we determined how the tumourigenic phosphoinositide 3-kinase/protein kinase B (PI3K/AKT), tumour-suppressive phosphatase and tensin homologue deleted on chromosome 10 (PTEN) and transforming growth factor-β (TGF-β) pathways are integrated ...
Santolaya Jacobo L - - 2013
Objective:In this study, we sought to characterize the tumor necrosis factor α (TNFα) baseline operational capacity in mature fetuses and their mothers prior to the onset of labor.Materials and Methods:We used an experimental pregnant nonhuman primate model to measure the plasma concentration of TNFα, TNF transmembrane receptor I (TNFRI), and ...
Menendez Laura - - 2013
Multipotent neural crest stem cells (NCSCs) have the potential to generate a wide range of cell types including melanocytes; peripheral neurons; and smooth muscle, bone, cartilage and fat cells. This protocol describes in detail how to perform a highly efficient, lineage-specific differentiation of human pluripotent cells to a NCSC fate. ...
Prota Andrea E - - 2013
Microtubule-stabilizing agents (MSAs) are efficacious chemotherapeutic drugs widely used for the treatment of cancer. Despite the importance of MSAs for medical applications and basic research, their molecular mechanisms of action on tubulin and microtubules remain elusive. Here, we determined high-resolution crystal structures of αβ-tubulin in complex with two unrelated MSAs, ...
Tweedy Brent - - 2013
We examined the effects of fish predation on emergent insect-mediated methyl mercury (MeHg) flux across a gradient of MeHg contamination in experimental ponds. Emergent insects were collected from ponds with (n=5) and without fish (n=5) over a six-week period using floating emergence traps. We found that the potential for MeHg ...
Castro-Rodriguez Jose A - - 2013
Objective. The aim of this post hoc analysis was to establish the relationship between FE(NO) levels and the asthma predictive index (API) among infants with recurrent wheezing. Methods. Infants with recurrent wheezing (three or more episodes) were recruited consecutively and online FE(NO) tests at tidal breathing with multiple breaths were ...
Balistrieri Glorilee G Infectious Diseases Division, Department of Medicine, Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226, - - 2013
Recent data provide evidence that co-infection with human immunodeficiency virus type 1 (HIV-1) and human T lymphotropic virus type 2 (HTLV-2) delays progression to AIDS compared to isolated HIV-1 infection. These results were linked to expression of the HTLV-2 transcriptional activating gene known as Tax2. Preliminary studies in lymphocytic systems ...
Hunter Rebecca A - - 2013
Despite growing reports on the biological action of nitric oxide (NO) as a function of NO payload, the validity of such work is often questionable due to the manner in which NO is measured and/or the solution composition in which NO is quantified. To highlight the importance of measurement technique ...
Ozsu Savas - - 2013
BACKGROUND AND OBJECTIVE: Pentraxin-3 (PTX-3) is a relatively new marker of inflammation which has not been previously tested (PPEs) and whether it discriminates complicated from uncomplicated in pleural effusions. We aimed to assess whether PTX-3 is an accurate biomarker of parapneumonic effusions PPEs. METHODS: The concentrations of pleural fluid PTX-3 ...
Steigenberger Barbara - - 2013
The synthesis of the triphosphates of 5-hydroxymethyl-, 5-formyl-, and 5-carboxycytidine and the incorporation of these building blocks into long DNA fragments using the polymerase chain reaction (PCR) are reported. In this way DNA fragments containing multiple hmC, fC, and caC nucleobases are readily accessible.
García-Ojeda Marcos E - - 2013
Transcription factors orchestrate T-lineage differentiation in the thymus. One critical checkpoint involves Notch1 signaling that instructs T-cell commitment at the expense of the B-lineage program. While GATA-3 is required for T cell specification, its mechanism of action is poorly understood. Here we show that GATA-3 works in concert with Notch1 ...
Bisschop Peter H - - 2013
The hypothalamus is a major target for glucocorticoids and key structure for hypothalamus-pituitary-adrenal (HPA) axis setpoint regulation. The enzyme 11beta hydroxysteroid dehydrogenase type 1 (11βHSD1) modulates glucocorticoid signalling in various tissues at the prereceptor level by converting biologically inactive cortisone to its active form cortisol. The objective of our study ...
Campos Francisco F Stroke Research Laboratory, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, - - 2013
The sphingosine 1-phosphate receptor agonist fingolimod reduces infarct size in rodent models of stroke and enhances blood-brain barrier integrity. Based on these observations, we hypothesized that combination of fingolimod with tissue plasminogen activator (tPA) would reduce the risk of hemorrhagic transformation associated with delayed administration of tPA. We evaluated the ...
Radom-Aizik Shlomit S Pediatric Exercise Research Center, Department of Pediatrics, University of California, Irvine, Irvine, California 92697-4094, USA. - - 2013
Natural killers (NK) cells are unique innate immune cells that increase up to fivefold in the circulating blood with brief exercise and are known to play a key role in first-response defense against pathogens and cancer immunosurveillance. Whether exercise alters NK cell gene and microRNA (miRNA) expression is not known. ...
Li Zheling - - 2013
Raman spectroscopy has been used for the first time to monitor interfacial stress transfer in poly(vinyl alcohol) nanocomposites reinforced with graphene oxide (GO). The graphene oxide nanocomposites were prepared by a simple mixing method and casting from aqueous solution. They were characterized using scanning electron microscopy, X-ray diffraction, and polarized ...
Ye Baihua - - 2013
The lack of robust and tunable chiral versions of cyclopentadienyl (Cp) ligands hampers progress in the development of catalytic asymmetric version of a myriad of reactions catalyzed by this ubiquitous ligand. Herein, we describe of a class of chiral Cp ligands with tunable steric parameters. Coordinated to transition metals, the ...
Mahfouz Reda Z RZ Department of Translational Hematology & Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH 44195, - - 2013
The cytidine analogs 5-azacytidine and decitabine, used to treat myelodysplastic syndromes (MDS), produce a molecular epigenetic effect, depletion of DNA-methyltransferase 1 (DNMT1). This action is S-phase dependent. Hence, genetic factors that decrease the half-lives of these drugs could impact efficacy. Documentation of such impact, and elucidation of underlying mechanisms, could ...
Singh Mandeep S - - 2013
One strategy to restore vision in retinitis pigmentosa and age-related macular degeneration is cell replacement. Typically, patients lose vision when the outer retinal photoreceptor layer is lost, and so the therapeutic goal would be to restore vision at this stage of disease. It is not currently known if a degenerate ...
Yin Li-Jung - - 2013
An acid protease from the broth of a 24-hour cultivated Aspergillus niger BCRC 32720 was purified to electrophoretical homogeneity by CM Sepharose FF and Sephacryl S-100 HR chromatographs. The specific activity, purification fold and yield were 23.29 kU/mg, 2.5 and 24.2%, respectively. Molecular mass (M) and N-terminal amino acid sequence ...
Velez Nahir N Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9041, - - 2013
Human African trypanosomiasis is caused by a single-celled protozoan parasite, Trypanosoma brucei. Polyamine biosynthesis is a clinically validated target for the treatment of human African trypanosomiasis. Metabolic differences between the parasite and the human polyamine pathway are thought to contribute to species selectivity of pathway inhibitors. S-adenosylmethionine decarboxylase (AdoMetDC) catalyzes ...
Chang Yao-Lung - - 2013
SUBJECT: This study investigates the placental autophagic activity in growth-restricted fetuses in the monochorionic (MC) twin model. PATIENTS AND METHODS: Forty MC twins were prospectively enrolled in this study, including 21 with and 19 without selective intrauterine growth restriction (sIUGR), defined as birth weight below the tenth percentile. The sIUGR ...
Ghi Tullio - - 2013
Objectives: To compare the longitudinal changes of the angle of progression (AoP) and the midline angle (MLA) during the active second stage according to the mode of delivery. Methods: A three-dimensional translabial ultrasound volume was acquired in a series of nulliparous women at the beginning of the active second stage ...
Dayer M J - - 2013
BACKGROUND: Since the introduction of the National Institute for Health and Clinical Excellence (NICE) guideline (CG064) in 2008 recommending cessation of antibiotic prophylaxis (AP) against infective endocarditis (IE), low level prescribing persists in the UK and is a potential reason why there has been no significant change in the general ...
Hajdu Steven I - - 2013
In the 3 decades from 1910 to 1940, more progress took place in cancer research and the diagnosis and treatment of cancers than during the prior centuries combined. The discovery of several carcinogens, precancerous conditions, and hereditary cancers adduced new thoughts about the genesis of cancers. Even though diagnostic radiology ...
Liu Shan - - 2013
Abstract Cationic antimicrobial peptides (CAPs) with antitumor activity have potential for use as novel antitumor agents because of their lower risk for induction of resistance. Of these peptides, magainin II (MG2) exhibited cytotoxicity in tumor cells only at high concentrations, likely due to the inefficiency of MG2 in cell membrane ...
Jahnke Ashlee A - - 2013
The synthesis and characterization of a series of poly(3-alkyltellurophene)s is described. Polymers are prepared by both electrochemical and Kumada catalyst transfer polymerization methods. These polymers have reasonably high molecular weights (Mn = 5,400 - 11,300), and can be processed in an analogous manner as their lighter analogs. All examples exhibit ...
Wilson Jacob M - - 2013
The purpose of the present study was to determine the effects of short-term supplementation with the free acid form of β-hydroxy-β-methylbutyrate (HMB-FA) on indices of muscle damage, protein breakdown, recovery and hormone status following a high-volume resistance training session in trained athletes. A total of twenty resistance-trained males were recruited ...
Chen Lei-Shih - - 2013
Purpose:The goal of this first-of-its-kind qualitative study was to examine the awareness, attitudes, and experiences among parents of autistic children regarding autism genetic testing.Methods:We conducted in-depth, individual, and semistructured interviews with 42 parents of autistic children with diverse racial/ethnic backgrounds. All interviews were audio-taped, transcribed, and coded into major themes ...
Veličković Nataša - - 2013
High fructose consumption is commonly associated with insulin resistance, disturbed glucose homeostasis and low-grade inflammation. Increased glucocorticoid production within adipose tissue has been implicated in the pathogenesis of fructose-induced metabolic syndrome. Immunosuppressive actions of glucocorticoids can be counter-regulated by macrophage migration inhibitory factor (MIF), which is recognised as a key ...
Deng Xiaodi X Department of Molecular Genetics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, - - 2013
ApoA-IV is an amphipathic protein that can emulsify lipids and has been linked to protective roles against cardiovascular disease and obesity. We previously reported an x-ray crystal structure of apoA-IV that was truncated at its N and C termini. Here, we have extended this work by demonstrating that self-associated states ...
Mast Natalia N Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio 44106, - - 2013
Cytochrome P450 46A1 (CYP46A1) is the cholesterol 24-hydroxylase initiating the major pathways of cholesterol removal from the brain, and bicalutamide (BIC) is a drug of choice for the treatment of progressive androgen-dependent prostate cancer. We evaluated the interactions of BIC with CYP46A1 by x-ray crystallography and by conducting solution and ...
Noda Shinji - - 2013
Objectives. Cathepsin V (CTSV) is a proteolytic enzyme potentially modulating angiogenic processes, collagen degradation and keratinocyte differentiation. We aimed to investigate the clinical association of serum CTSV levels and the mechanism by which CTSV expression is altered in SSc.Methods. Serum CTSV levels were determined by ELISA in 51 SSc and ...
Herrin Melissa A - - 2013
BACKGROUND: Chronic obstructive pulmonary disease (COPD) and hypertension both increase the risk of congestive heart failure (CHF). Current clinical trials do not inform selection of combination antihypertensive therapy among patients with COPD. We performed a comparative effectiveness study to investigate whether choice of dual agent antihypertensive therapy is associated with ...
Ngan Kee W D - - 2013
Describing the relationship between magnitude of response, probability of response, dose and time is difficult using traditional two-dimensional dose-response curves. We devised a novel way of presentation in four dimensions. Data from a previous study of epidural bupivacaine and ropivacaine given for labour analgesia were re-analysed. For a range of ...
Dominissini Dan - - 2013
N(6)-methyladenosine-sequencing (m(6)A-seq) is an immunocapturing approach for the unbiased transcriptome-wide localization of m(6)A in high resolution. To our knowledge, this is the first protocol to allow a global view of this ubiquitous RNA modification, and it is based on antibody-mediated enrichment of methylated RNA fragments followed by massively parallel sequencing. ...
Agee Carl B - - 2013
We report data on the martian meteorite, Northwest Africa (NWA) 7034, which shares some petrologic and geochemical characteristics with known martian (SNC, i.e., Shergottite, Nakhlite, and Chassignite) meteorites, but also possesses some unique characteristics that would exclude it from the current SNC grouping. NWA 7034 is a geochemically enriched crustal ...
Ma Jun - - 2013
We report measurements and modeling of thermal conductivity in periodic three-dimensional dielectric nanostructures: silicon inverse opals. Such structures represent a three-dimensional "phononic crystal" but affect heat flow instead of acoustics. Employing the Stober method, we fabricate high quality silica opal templates that on filling with amorphous silicon, etching and recrystallizing ...
de la Cruz-Herrera Carlos Felipe - - 2013
Infection with Helicobacter pylori cytotoxin-associated gene A (CagA) positive strains is associated with the development of gastric cancer. However, some reports have failed to demonstrate an increased frequency of CagA antibodies in gastric cancer patients. We evaluated the response of IgG antibody and subclasses IgG1 and IgG2 against both, CagA ...
McLinden James H JH Department of Internal Medicine, Division of Infectious Diseases, Iowa City Veterans Affairs Medical Center and University of Iowa, Iowa City, IA 52242, - - 2013
GB virus type C (GBV-C) is a lymphotropic virus that can cause persistent infection in humans. GBV-C is not associated with any disease, but is associated with reduced mortality in human immunodeficiency virus type 1 (HIV-1)-infected individuals. Related viruses have been isolated from chimpanzees (GBV-Ccpz) and from New World primates ...
Morales-Santana Sonia S Bone Metabolic Unit, Red Temática de Investigación Cooperativa en Envejecimiento y Fragilidad, Endocrinology Division, Hospital Universitario San Cecilio, Granada, - - 2013
Wnt/β-catenin signaling is related to the pathogenesis of several diseases. Sclerostin is an inhibitor of Wnt/β-catenin signaling. However, there are few data regarding the sclerostin levels and vascular disease. Our aim was to examine the relationship between serum sclerostin and atherosclerotic disease (AD) in type 2 diabetes mellitus (T2DM). We ...
Buckley Benjamin R - - 2013
A cheap and reliable process for the modified Wenker cyclization to afford aziridines has been achieved using biphasic condtions for a range of aminol alcohol starting materials.
Sassolas Genevieve Marie - - 2013
Background: The thyroid is highly sensitive to the carcinogenic effect of radiation in children. We compared, in patients with and without earlier childhood radiation, the features of papillary thyroid cancer (PTC) diagnosed in later childhood through young adulthood. Methods: Patients were from the Rhone Alpes Thyroid Cancer Registry. Twenty four ...
Zhang Qifang Q Department of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute at City of Hope, Duarte, CA 91010, - - 2013
STAT3 operates in both cancer cells and tumor-associated immune cells to promote cancer progression. As a transcription factor, it is a highly desirable but difficult target for pharmacologic inhibition. We have recently shown that the TLR9 agonists CpG oligonucleotides can be used for targeted siRNA delivery to mouse immune cells. ...
Hoang Danh-Tai - - 2013
We study the low-temperature behavior and the phase transition of a thin film by Monte Carlo simulation. The thin film has a simple cubic lattice structure where each site is occupied by a Potts parameter which indicates the molecular orientation of the site. We take only three molecular orientations in ...
Audigeos D - - 2013
Unveiling the genetic basis of local adaptation to environmental variation is a major goal in molecular ecology. In rugged landscapes characterized by environmental mosaics, living populations and communities can experience steep ecological gradients over very short geographical distances. In lowland tropical forests, interspecific divergence in edaphic specialization (for seasonally flooded ...
Lyford-Pike Sofia S Department of Otolaryngology-Head and Neck Surgery, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, - - 2013
Human papillomavirus-associated head and neck squamous cell carcinomas (HPV-HNSCC) originate in the tonsils, the major lymphoid organ that orchestrates immunity to oral infections. Despite its location, the virus escapes immune elimination during malignant transformation and progression. Here, we provide evidence for the role of the PD-1:PD-L1 pathway in HPV-HNSCC immune ...
Svreck Magali - - 2013
Microsatellite instability (MSI) due to mismatch repair (MMR) deficiency is reported in 5-10% of colorectal cancers complicating inflammatory bowel diseases (IBD-CRCs). The molecular mechanisms underlying MMR-deficiency may be different in IBD-CRCs, and in sporadic and hereditary MSI tumours. Here we hypothesize that over-expression of miR-155 and miR-21, two inflammation-related miRNAs ...
Liebetrau Christoph - - 2013
BACKGROUND: The release kinetics of copeptin in patients with acute myocardial infarction (AMI) have been difficult to establish.METHODS: We analyzed the release kinetics of copeptin in patients with hypertrophic obstructive cardiomyopathy undergoing transcoronary ablation of septal hypertrophy (TASH) as a model of AMI. We included 21 consecutive patients who underwent ...
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