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Hutton Paul - - 2013
Background: More effective psychological treatments for psychosis are required. Case series data and pilot trials suggest metacognitive therapy (MCT) is a promising treatment for anxiety and depression. Other research has found negative metacognitive beliefs and thought-control strategies may be involved in the development and maintenance of hallucinations and delusions. The ...
Jiao L L Houston VA Health Services Research Center of Excellence, Michael E. DeBakey VA Medical Center, Houston, TX, USA. - - 2013
Sleep duration is dependent on circadian rhythm that controls a variety of key cellular functions. Circadian disruption has been implicated in colorectal tumorigenesis in experimental studies. We prospectively examined the association between sleep duration and risk of colorectal cancer (CRC). In the Women's Health Initiative Observational Study, 75 828 postmenopausal ...
Setabutr Dhave - - 2013
OBJECTIVES/HYPOTHESES: Nasal bone length is commonly referenced in the rhinoplasty literature. It has been suggested that short nasal bone length may predispose one to a greater risk of middle vault collapse after rhinoplasty. However, there are limited data available on what constitutes the normal dimensions of these pertinent structures of ...
Venkata Subbarao R - - 2013
Employing the concept of effective Hamiltonians, an analytical theory is introduced to describe transitions in a multi-level system in nuclear magnetic resonance (NMR) spectroscopy. Specifically, the discussion is centered towards the treatment of selective and non-selective excitations in static quadrupolar spin (I > 1/2) systems. To this end, effective radiofrequency ...
Olivan-Blázquez Bárbara - - 2013
ABSTRACT: BACKGROUND: Fibromyalgia is a prevalent chronic rheumatic disease of great clinical importance. Recent studies have found raised levels of glutamate in the insula, hippocampus and posterior cingulate cortex regions of the brains of fibromyalgia (FM) patients. This finding has led researchers to speculate about the usefulness of glutamate-blocking drugs ...
Magliulo Maria - - 2013
Anchored, biotinylated phospholipids forming the capturing layers in an electrolyte-gated organic field-effect transistor (EGOFET) allow label-free electronic specific detection at a concentration level of 10 nM in a high ionic strength solution. The sensing mechanism is based on a clear capacitive effect across the PL layers involving the charges of ...
Savukoski Tanja - - 2013
BACKGROUND: Autoantibodies to cardiac troponins (cTnAAbs) can interfere with the measurement of cardiac troponin I (cTnI) by immunoassays for the diagnosis of myocardial infarction. Therefore, we determined the cTnI binding sites and IgG subclasses of circulating cTnAAbs.METHODS: We studied epitope specificity with sandwich-type immunoassays by measuring the recovery of troponin ...
van Meijl Leonie E C - - 2013
Studies have suggested that two major milk constituents, casein and Ca, favourably affect postprandial responses. However, effects of milk on postprandial metabolism are unknown. We therefore investigated effects of using milk with a fat-containing meal on lipid and glucose responses in overweight men. To identify the constituent responsible for possible ...
Sutherland M A - - 2013
The objectives of this study were to determine: 1) the effect of castration, dehorning, or both on the physiology and behavior of 3-mo-old Holstein calves; and 2) the effectiveness of pain relief to alleviate the pain caused by castration and/or dehorning. Holstein calves (n = 80) were assigned randomly to ...
Nascimento-Carvalho Cristiana M - - 2013
Pleural effusion (PE), a complication of community-acquired pneumonia (CAP), is usually attributed to a bacterial infection. Nonetheless, viral infections have not been investigated routinely. We searched for bacterial and viral infections among 277 children hospitalized with CAP. Among these children 206 (74%) had radiographic confirmation, of whom 25 (12%) had ...
Sadoughi Golnaz - - 2013
We present an investigation on the optimisation of solid-state dye sensitized solar cells (SDSCs) comprising mesoporous tin oxide photoanodes infiltrated with poly(3-hexylthiophene-2,5-diyl) (P3HT) hole conductor and sensitized with an organic dye. We chose both the SnO(2) and P3HT for their high charge carrier mobilities and conductivities, but as a result ...
Zhang Heng H State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, No. 5 Yiheyuan Road, Beijing 100871, - - 2013
The type VI secretion system (T6SS), a multisubunit needle-like apparatus, has recently been found to play a role in interspecies interactions. The gram-negative bacteria harboring T6SS (donor) deliver the effectors into their neighboring cells (recipient) to kill them. Meanwhile, the cognate immunity proteins were employed to protect the donor cells ...
Glavind J - - 2013
Objectives: To compare the residual myometrial thickness and the size of the caesarean scar defect in single- and double-layer uterotomy closure after first elective caesarean section. Methods: A retrospective cohort study was conducted in 149 women at least six months after an uncomplicated, elective caesarean delivery. Two-dimensional transvaginal ultrasonography measures ...
Hayashi Shirley Yumi - - 2013
Left ventricular (LV) dyssynchrony is a known cause of mortality in patients with heart failure and may possibly play a similar role in patients with chronic kidney disease (CKD) in whom sudden death is one of the most common and as yet not fully explained cause of death. LV synchronicity ...
Chen Gui - - 2013
Ironing out a solution: Chemical and visible-light-driven water oxidation by iron complexes and iron salts at pH 7-9 has been investigated. The iron complexes and salts act as precatalysts to produce α-Fe(2) O(3) nanoparticles that are the real catalyst for the water oxidation with a turnover number over 1000.
Chen Yuan-Fang - - 2013
ABSTRACT: BACKGROUND: More than 70% of patients with depression who see their doctors experience insomnia. Insomnia treatment is a very important link for depression treatment. Furthermore, antidepression treatment is also important for depression insomnia. In acupuncture, LU-7 (Lie Que) and KID-6 (Zhao Hai), which are two of the eight confluence ...
Olsen S C - - 2013
Regulations in the United States require animal biosafety level 3 (ABSL-3) or biosafety level 3 agriculture (BSL-3-Ag) containment for many endemic zoonotic pathogens and etiologic agents of foreign animal diseases. In an effort to protect public health, billions of dollars were invested in regulatory programs over many years to reduce ...
Vasaikar Suhas V - - 2013
ABSTRACT: BACKGROUND: Genetic networks control cellular functions. Aberrations in normal cellular function are caused by mutations in genes that disrupt the fine tuning of genetic networks and cause disease or disorder. However, the large number of signalling molecules, genes and proteins that constitute such networks, and the consequent complexity of ...
Wu Jiao-Hui JH Department of Medicine, Duke University Medical Center, Durham, NC 27710, - - 2013
Kalirin is a multifunctional protein that contains 2 guanine nucleotide exchange factor domains for the GTPases Rac1 and RhoA. Variants of KALRN have been associated with atherosclerosis in humans, but Kalirin's activity has been characterized almost exclusively in the central nervous system. We therefore tested the hypothesis that Kalirin functions ...
Chu Yi Y Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, - - 2013
Development of calcific aortic valve stenosis involves multiple signaling pathways, which may be modulated by peroxisome proliferator-activated receptor-γ). This study tested the hypothesis that pioglitazone (Pio), a ligand for peroxisome proliferator-activated receptor-γ, inhibits calcification of the aortic valve in hypercholesteremic mice. Low density lipoprotein receptor(-/-)/apolipoprotein B(100/100) mice were fed a ...
Sumner Rebecca P RP Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, - - 2013
Vectors based on vaccinia virus (VACV), the vaccine used to eradicate smallpox, are currently popular candidates for the vaccination against numerous infectious diseases including malaria and AIDS. Although VACV induces robust cellular and humoral responses, enhancing the safety and efficacy of these vectors remains an important area of research. Here, ...
Senanayake Sanjaya D - - 2013
Oxides play a central role in important industrial processes, includingapplications such as the production of renewable energy, remediation of environmental pollutants, and the synthesis of fine chemicals. They were originally used as catalyst supports and were thought to be chemically inert, but now they are used to build catalysts tailored ...
Roser Timo - - 2013
A sensitive and specific triage of patients with primary or secondary headache is a major concern in evaluating pediatric headache patients. History and physical examination are the major tools for differentiating primary headache disorders from symptomatic headaches caused by defined pathologies. If the criteria of the International Headache Society for ...
Balatti S - - 2013
Multilevel operation in resistive switching memory (RRAM) based on HfO(x) is demonstrated through variable sizes and orientations of the conductive filament. Memory states with the same resistance, but opposite orientation of defects, display a different response to an applied read voltage, therefore allowing an improvement of the information stored in ...
Tian Chengju C Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, - - 2013
Individuals working in commercial hog confinement facilities have elevated incidences of headaches, depression, nausea, skeletal muscle weakness, fatigue, gastrointestinal disorders, and cardiovascular diseases, and the molecular mechanisms for these nonrespiratory ailments remain incompletely undefined. A common element underlying these diverse pathophysiologies is perturbation of intracellular Ca(2+) homeostasis. This study assessed ...
Neto Elias Chaibub EC Sage Bionetworks, Seattle, Washington 98109, USA. - - 2013
Current efforts in systems genetics have focused on the development of statistical approaches that aim to disentangle causal relationships among molecular phenotypes in segregating populations. Reverse engineering of transcriptional networks plays a key role in the understanding of gene regulation. However, transcriptional regulation is only one possible mechanism, as methylation, ...
Richardson Jeremy O - - 2013
We report a combined theoretical and experimental study of the water octamer-h16. The calculations used the ring-polymer instanton method to compute tunnelling paths and splittings in full dimensionality. The experiments measured extensive high resolution spectra near 1.4 THz, for which isotope dilution experiments and group theoretical analysis support assignment to ...
Nitta Hidetoshi - - 2013
PURPOSE: The anaphylatoxin C5a is a chemoattractant that induces leukocyte migration via C5a receptor (C5aR). There is emerging evidence that C5a is generated in the cancer microenvironment. We therefore sought C5aR expression and a direct influence of the C5a-C5aR axis on cancer cells. EXPERIMENTAL DESIGN: C5aR expression was investigated in ...
Timofeeva Olga A - - 2013
Activation of STAT3 in cancers leads to gene expression promoting cell proliferation and resistance to apoptosis, as well as tumor angiogenesis, invasion, and migration. In the characterization of effects of ST3-H2A2, a selective inhibitor of the STAT3 N-terminal domain (ND), we observed that the compound induced apoptotic death in cancer ...
Street Robert A - - 2013
Ternary blend bulk heterojunction organic solar cells comprising either a polythiophene donor and two fullerene acceptors or two polythiophene donors and a fullerene acceptor are shown to have unique electronic properties. Measurements of the photocurrent spectral response and the open-circuit voltage show that the HOMO and LUMO levels change continuously ...
Gilbert Mary E - - 2013
Thyroid hormones (TH) are essential for brain development and iodine is required for TH synthesis. Environmental chemicals that perturb the thyroid axis result in modest reductions in TH, yet there is a paucity of data on the extent of neurological impairments associated with low level TH disruption. This study examined ...
Karunakaran Denuja D Centre for Vascular Research, School of Medical Sciences, University of New South Wales, Sydney, - - 2013
Macrophage-specific apolipoprotein E (apoE) secretion plays an important protective role in atherosclerosis. However, the precise signaling mechanisms regulating apoE secretion from primary human monocyte-derived macrophages (HMDMs) remain unclear. Here we investigate the role of protein kinase C (PKC) in regulating basal and stimulated apoE secretion from HMDMs. Treatment of HMDMs ...
Tang Weijun - - 2013
One of four: A chiral phosphoric acid enables asymmetric hydrogenation of imines with an achiral iridium catalyst by virtue of noncovalent interactions. These interactions lead to the formation of a highly organized ternary complex, and the hydride is transferred highly enantioselectively.
Guo Kun - - 2013
Perineural invasion (PNI) is one of the most important causes of local recurrence and poor survival in pancreatic cancer. However, the exact mechanism of PNI is still not clear. In this study, we sought to identify the reciprocal signaling interactions between sympathetic nerves and pancreatic cancer cells and the underlying ...
Coyle Jason P - - 2013
Several copper(I) iminopyrrolidinates have been evaluated by thermogravimetric analysis (TGA) and solution based (1)H NMR studies to determine their thermal stability and decomposition mechanisms. Iminopyrrolidinates were used as a ligand for copper(I) to block previously identified decomposition routes of carbodiimide deinsertion and β-hydrogen abstraction. The compounds copper(I) isopropyl-iminopyrrolidinate (1) and ...
Miyake Yoshihiro - - 2013
It's complex: Ruthenium-catalyzed [3+2] cycloaddition of ethynylcyclopropanes with aldehydes and aldimines has been found to give the corresponding 2-ethynyltetrahydrofurans or -pyrrolidines in high to excellent yields. In both cases, the formation of a ruthenium allenylidene complex as a key reactive intermediate is supported by density functional theory calculations. Cp*=η(5) -C(5) ...
Su Liap Tat - - 2013
A hetero-nanostructured photoanode with enhanced near-infrared light harvesting is developed for photo-electrochemical cells. By spatially coating upconversion nanoparticles and quantum dot photosensitizers onto TiO(2) inverse opal, this architecture allows direct irradiation of upconversion nanoparticles to emit visible light that excites quantum dots for charge separation. Electrons are injected into TiO(2) ...
Willis Rosalind - - 2013
Objectives. Minority ethnic groups are often assumed to exchange higher levels of informal support than the majority population, despite evidence that controlling for socioeconomic and health inequalities eliminates differences. Using a unique data set from England and Wales, we examined instrumental support across ethnic groups in mid and later life.Method. ...
Sündermann Simon H SH Division of Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland. - - 2013
Implantation of an annuloplasty ring is an essential component of a durable mitral valve repair. Currently available off-the-shelf rings still do not cover all the variations in mitral annulus anatomy and pathology from subject to subject. Computed tomography (CT) and echo imaging allow for 3-D segmentation of the mitral valve ...
Hyshka Elaine - - 2013
BACKGROUND: North America's first supervised injection facility-Insite-opened in Vancouver in 2003 under a special federal legal exemption. Insite has faced significant political and legal opposition, which culminated in a recent Supreme Court of Canada ruling that ordered the federal Minister of Health to extend the facility's exemption and cited evidence ...
de Groot Jens C - - 2013
Amorfrutins are a family of natural products with high affinity to the peroxisome proliferator-activated receptor γ (PPARγ), a nuclear receptor regulating lipid and glucose metabolism. The PPARγ agonist rosiglitazone increases insulin sensitivity and is effective against type II diabetes, but has severe adverse effects including weight gain. Amorfrutins improve insulin ...
Kluger Martin S MS Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA. - - 2013
To assess the role claudin-5, an endothelial cell (EC) tight junction protein, plays in establishing basal permeability levels in humans by comparing claudin-5 expression levels in situ and analyzing junctional organization and function in 2 widely used models of cultured ECs, namely human dermal microvascular (HDM)ECs and human umbilical vein ...
Fournier Carole - - 2013
A trans-packaging system for hepatitis C virus (HCV) replicons lacking envelope glycoproteins was developed. The replicons were efficiently encapsidated into infectious particles after expression in trans of homologous HCV envelope proteins under the control of an adenoviral vector. Interestingly, expression in trans of core or core, p7 and NS2 with ...
Kowada A - - 2013
SUMMARY The incidence of active tuberculosis (TB) and latent tuberculosis infection (LTBI) in inmates and prison staff is higher than that in the general population. Mycobacterium tuberculosis-specific interferon-gamma release assays (IGRAs) provide more accurate diagnosis of M. tuberculosis infection with higher specificity than the tuberculin skin test (TST). To assess ...
Moberg Christina - - 2013
Two views: The mechanism of the conjugate addition of linear aldehydes to nitro olefins has been investigated by two research groups. In spite of extensive experimental data, important questions remain unanswered (see scheme; TMS=trimethylsilyl, En=enamine).
Carey Robert E - - 2013
ABSTRACT: BACKGROUND: Expansins are plant cell wall loosening proteins encoded by a large superfamily of genes, consisting of four families named EXPA, EXPB, EXLA, and EXLB. The evolution of the expansin superfamily is well understood in angiosperms, thanks to synteny-based evolutionary studies of the gene superfamily in Arabidopsis, rice, and ...
Granata Veronica - - 2013
The magnetic properties of the triple-layered Sr(4)Ru(3)O(10) have been investigated by means of neutron scattering diffraction. At zero field we find that the magnetic moments are ferromagnetically coupled and oriented along the c-axis with no signatures of either long-range antiferromagnetic order or ferromagnetic components in the ab-plane. The field dependence ...
Pollock Bruce E - - 2013
BACKGROUND AND PURPOSE: The best management of patients with unruptured brain arteriovenous malformations (BAVM) is controversial. In this study, we analyzed the stroke rate and functional outcomes of patients having stereotactic radiosurgery (SRS) for unruptured BAVM using the same eligibility criteria and primary end points as the ARUBA trial. METHODS: ...
Klöting Ingrid - - 2013
It has previously been shown that high-calorie diet alters the function of the mammalian circadian clock and that obesity has an influence on circadian organization of hormone secretion. That prompted us to test whether inbred Wistar Ottawa Karlsburg W (RT1(u)) (WOKW) rats developing facets of the metabolic syndrome show changes ...
Tarhouni K - - 2013
OBJECTIVE: Flow- (shear stress-)mediated outward remodeling of resistance arteries is involved in collateral growth during postischemic revascularization. As this remodeling is especially important during pregnancy, we hypothesized that estrogens may be involved. A surgical model eliciting a local increase in blood flow in 1 mesenteric resistance artery was used in ...
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