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Results 451 - 500 of 2748
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Dal Cin Paola - - 2013
The past 20 years have witnessed extraordinary advances in the field of cytogenetics, with the discovery that a multitude of neoplasms is characterized by identifiable chromosomal changes. The ability of Cytogenetics to aid in the identification and precise classification of a variety of neoplasms has not gone unnoticed by Cytology. ...
Ma Yi-Hui - - 2013
KRAS is an attractive pancreatic ductal adenocarcinoma (PDAC) therapeutic target. E3 ligase is thought to be the component of the ubiquitin conjugation system that is directly responsible for substrate recognition. In this study, an engineered E3 ubiquitin ligase (RC-U) was generated to target the KRAS oncoprotein for ubiquitination and degradation. ...
Pacchioni Gianfranco - - 2013
Understanding the interaction of small metal clusters and isolated atoms with oxide surfaces is crucial in order to rationalize the properties of heterogeneous catalysts composed of sub-nanometer metal particles dispersed on an oxide support. The interaction with the oxide surface can significantly alter the original properties of the metal deposit. ...
Mneimneh Wadad Sami - - 2013
Abstract Background: Histopathologic findings of gonadal torsion in neonates and infants (GTNI) are poorly defined in the literature. We describe herein the histopathologic spectrum of gonadal torsion (GT) with emphasis on the pediatric population and on features specific for NI (<=1 year of age). Design: Twenty-five cases of GTNI (6 ...
Ye Xingchen - - 2013
We report a dramatically improved synthesis of colloidal gold nanorods (NRs) using a binary surfactant mixture composed of hexadecyltrimethylammonium bromide (CTAB) and sodium oleate (NaOL). Both thin (diameter < 25 nm) and thicker (diameter > 30 nm) gold NRs with exceptional monodispersity and broadly tunable longitudinal surface plasmon resonance can ...
Niland Stephan - - 2013
The snake venom component rhodocetin-αβ (RCαβ) stimulates endothelial cell motility in an α2β1 integrin-independent manner. We aimed to elucidate its cellular and molecular mechanisms. We identified neuropilin-1 (Nrp1) as a novel target of RCαβ by protein-chemical methods. RCαβ and vascular endothelial growth factor (VEGF)-A avidly bind to Nrp1. Instead of ...
Carvalho Luiz Fernando Pina - - 2013
Background: There is increasing evidence that oxidative stress is one of the key factors for progression of endometriosis. In this prospective controlled trial, we measured 6 different biomarkers of oxidative stress targeting protein, lipid, and DNA to quantify the severity and progression of endometriosis and establish a diagnostic marker for ...
Saito Nozomi - - 2013
Reactions of pyridynes with cyclic urea and 1-methyl-2-oxazolidone were demonstrated. 3,4-Pyridyne and 2,3-pyridyne were reacted with N,N-dimethylimidazolidone, N,N-dimethylpropylene urea, and 1-methyl-2-oxazolidone to give the corresponding pyridodiazepines, pyridodiazocines, and pyridooxazepines, respectively.
Tie Yanmei - - 2013
Presurgical language mapping for patients with lesions close to language areas is critical to neurosurgical decision-making for preservation of language function. As a clinical noninvasive imaging technique, functional MRI (fMRI) is used to identify language areas by measuring blood-oxygen-level dependent (BOLD) signal change while patients perform carefully timed language vs. ...
Pitre Chantalle A J - - 2013
Legionella pneumophila, an intracellular parasite of protozoa, possesses a distinct dimorphic life cycle that alternates between the vegetative replicative form and the resilient but highly infectious cyst form. Previously, temporally expressed heterodimeric IHF was shown to be required for differentiation into the cyst form. However, the precise regulatory mechanisms controlling ...
Farra Sharon - - 2013
The purpose of this study was to examine the effects of virtual reality simulation (VRS) on learning outcomes and retention of disaster training. The study used a longitudinal experimental design using two groups and repeated measures. A convenience sample of associate degree nursing students enrolled in a disaster course was ...
Sustaita Diego - - 2013
Human beings have been credited with unparalleled capabilities for digital prehension grasping. However, grasping behaviour is widespread among tetrapods. The propensity to grasp, and the anatomical characteristics that underlie it, appear in all of the major groups of tetrapods with the possible exception of terrestrial turtles. Although some features are ...
Gomez-Casati Diego F - - 2013
Glycosyltransferases (GTs) are a ubiquitous group of enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Nucleotide-sugars, lipid phosphate sugars and phosphate sugars can act as activated donor molecules while acceptor substrates involve carbohydrates, proteins, lipids, DNA and also, numerous ...
Ribeiro Grazielle Alves - - 2013
OBJECTIVES: The pterocarpanquinone LQB-118, previously demonstrated to be effective in vivo via oral delivery, was investigated for its mechanism in selective parasite killing. METHODS: Oxidative stress in Leishmania amazonensis was analysed by evaluating reactive oxygen species (ROS) production (2',7'-dichlorodihydrofluorescein diacetate) and the loss of mitochondrial membrane potential (ΔΨ(m)) using rhodamine, ...
Uczaj Ukasz - - 2013
ABSTRACT: BACKGROUND: Dalmatia is an interesting place to study the use of wild greens as it lies at the intersection of influence of Slavs, who do not usually use many species of wild greens, and Mediterranean culinary culture, where the use of multiple wild greens is common. The aim of ...
Sadeghi Ali Asghar - - 2013
Abstract In the present study, electrophoretic deposition (EPD) was used to obtain dense layers of TiO¬2 in four organic media, methaol, ethanol, 1-propanol and butanol with different TiO2 nanoparticles concenteration of 1-8 (g/lit). Microstructural study of the obtained layers by scanning electron (SEM) and optical microscope (OM) revealed that the ...
Won Dahae - - 2013
Acute promyelocytic leukemia is characterized by the rearrangement of the retinoic acid receptor alpha (RARA) gene and its fusion with other genes. We report a novel case of variant acute promyelocytic leukemia with the karyotype der(2)t(2;17)(q32;q21). Array comparative genomic hybridization revealed distinct chromosome breakpoints within the RARA and oligonucleotide/oligosaccharide-binding fold ...
Singh Anup Kumar - - 2013
Glomus tumor is a rare predominantly benign soft tissue tumor. Lower respiratory tract is an uncommon site of origin of glomus tumor and hence endobronchial glomus tumor is extremely rare. This is mostly benign and identified incidentally on imaging. Diagnosis is confirmed by immunohistochemical staining and resection is the treatment ...
Chen Gui - - 2013
Ironing out a solution: Chemical and visible-light-driven water oxidation by iron complexes and iron salts at pH 7-9 has been investigated. The iron complexes and salts act as precatalysts to produce α-Fe(2) O(3) nanoparticles that are the real catalyst for the water oxidation with a turnover number over 1000.
Chen Yuan-Fang - - 2013
ABSTRACT: BACKGROUND: More than 70% of patients with depression who see their doctors experience insomnia. Insomnia treatment is a very important link for depression treatment. Furthermore, antidepression treatment is also important for depression insomnia. In acupuncture, LU-7 (Lie Que) and KID-6 (Zhao Hai), which are two of the eight confluence ...
Olsen S C - - 2013
Regulations in the United States require animal biosafety level 3 (ABSL-3) or biosafety level 3 agriculture (BSL-3-Ag) containment for many endemic zoonotic pathogens and etiologic agents of foreign animal diseases. In an effort to protect public health, billions of dollars were invested in regulatory programs over many years to reduce ...
Vasaikar Suhas V - - 2013
ABSTRACT: BACKGROUND: Genetic networks control cellular functions. Aberrations in normal cellular function are caused by mutations in genes that disrupt the fine tuning of genetic networks and cause disease or disorder. However, the large number of signalling molecules, genes and proteins that constitute such networks, and the consequent complexity of ...
Senanayake Sanjaya D - - 2013
Oxides play a central role in important industrial processes, includingapplications such as the production of renewable energy, remediation of environmental pollutants, and the synthesis of fine chemicals. They were originally used as catalyst supports and were thought to be chemically inert, but now they are used to build catalysts tailored ...
Roser Timo - - 2013
A sensitive and specific triage of patients with primary or secondary headache is a major concern in evaluating pediatric headache patients. History and physical examination are the major tools for differentiating primary headache disorders from symptomatic headaches caused by defined pathologies. If the criteria of the International Headache Society for ...
Balatti S - - 2013
Multilevel operation in resistive switching memory (RRAM) based on HfO(x) is demonstrated through variable sizes and orientations of the conductive filament. Memory states with the same resistance, but opposite orientation of defects, display a different response to an applied read voltage, therefore allowing an improvement of the information stored in ...
Hyshka Elaine - - 2013
BACKGROUND: North America's first supervised injection facility-Insite-opened in Vancouver in 2003 under a special federal legal exemption. Insite has faced significant political and legal opposition, which culminated in a recent Supreme Court of Canada ruling that ordered the federal Minister of Health to extend the facility's exemption and cited evidence ...
de Groot Jens C - - 2013
Amorfrutins are a family of natural products with high affinity to the peroxisome proliferator-activated receptor γ (PPARγ), a nuclear receptor regulating lipid and glucose metabolism. The PPARγ agonist rosiglitazone increases insulin sensitivity and is effective against type II diabetes, but has severe adverse effects including weight gain. Amorfrutins improve insulin ...
Fournier Carole - - 2013
A trans-packaging system for hepatitis C virus (HCV) replicons lacking envelope glycoproteins was developed. The replicons were efficiently encapsidated into infectious particles after expression in trans of homologous HCV envelope proteins under the control of an adenoviral vector. Interestingly, expression in trans of core or core, p7 and NS2 with ...
Kowada A - - 2013
SUMMARY The incidence of active tuberculosis (TB) and latent tuberculosis infection (LTBI) in inmates and prison staff is higher than that in the general population. Mycobacterium tuberculosis-specific interferon-gamma release assays (IGRAs) provide more accurate diagnosis of M. tuberculosis infection with higher specificity than the tuberculin skin test (TST). To assess ...
Moberg Christina - - 2013
Two views: The mechanism of the conjugate addition of linear aldehydes to nitro olefins has been investigated by two research groups. In spite of extensive experimental data, important questions remain unanswered (see scheme; TMS=trimethylsilyl, En=enamine).
Granata Veronica - - 2013
The magnetic properties of the triple-layered Sr(4)Ru(3)O(10) have been investigated by means of neutron scattering diffraction. At zero field we find that the magnetic moments are ferromagnetically coupled and oriented along the c-axis with no signatures of either long-range antiferromagnetic order or ferromagnetic components in the ab-plane. The field dependence ...
Stout Gerdine J - - 2013
Xeroderma pigmentosum (XP), a UV sensitivity syndrome characterized by skin hyperpigmentation, premature aging and increased skin cancer, is caused by defects in the nucleotide excision repair (NER) pathway. XP shares phenotypical characteristics with telomere-associated diseases like Dyskeratosis congenita and mouse models with dysfunctional telomeres, including mice deficient for telomerase (Terc-/- ...
Ogba Ofonime M - - 2013
BACKGROUND: Most HIV-seropositive people who develop AIDS die from an opportunistic infection, such as pulmonary mycosis, rather than the HIV infection itself. Data on the pattern of respiratory mycoses and the immunological profile of HIV-seropositive patients in Nigeria are scarce and uncoordinated, so we investigated respiratory mycosis and CD4 count ...
Czopek Anna - - 2013
A computer aided ligand design study of imidazolidine-2,4-dione derivatives was conducted in order to obtain compounds with dual 5-HT(1A) receptor and serotonin transporter (SERT) affinity. According to molecular modeling results, series of Mannich bases were chosen and synthesized. Investigated compounds were tested for 5-HT(1A) , 5-HT(2A) , α(1) and SERT ...
Burdick Sanchez Nicole C - - 2013
A study was conducted to determine the effect of feeding yeast cell wall (YCW) products on the physiological and acute phase responses of crossbred, newly-received feedlot heifers to an endotoxin challenge. Heifers (n = 24; 219 ± 2.4 kg) were separated into treatment groups receiving either a control diet (n ...
Löhr Iren Høyland - - 2013
OBJECTIVES: To investigate the duration of faecal carriage of CTX-M-15-producing Klebsiella pneumoniae in infants colonized during a nosocomial neonatal intensive care unit (NICU) outbreak after discharge from hospital, possible risk factors for long-term colonization and transmission to household contacts (HCs). METHODS: Fifty-one infants colonized with two unrelated clones of CTX-M-15 ...
Randles Edward Graham - - 2013
Liposomes offer a method to encapsulate high concentrations of a drug, protecting the therapeutic upon in vivo administration. With an appropriate mechanism to manipulate lipid bilayer permeability, liposomes have the potential to deliver encapsulated drugs in a spatially and temporally controlled manner. In this investigation the photosensitizer aluminum phthalocyanine disulfonic ...
Jacobs Gerald H - - 2013
All mammalian cone photopigments are derived from the operation of representatives from two opsin gene families (SWS1 and LWS in marsupial and eutherian mammals; SWS2 and LWS in monotremes), a process that produces cone pigments with respective peak sensitivities in the short and middle-to-long wavelengths. With the exception of a ...
Barlow Axel - - 2013
Evidence from numerous Pan-African savannah mammals indicates that open-habitat refugia existed in Africa during the Pleistocene, isolated by expanding tropical forests during warm and humid interglacial periods. However, comparative data from other taxonomic groups are currently lacking. We present a phylogeographic investigation of the African puff adder (Bitis arietans), a ...
Postiaux Guy - - 2013
Acute viral bronchiolitis (AVB) is the most common disorder and the leading cause of respiratory failure in infants (<24 months of age). Respiratory syncytial virus is the most common pathogen (85%), but other organisms produce a similar clinical picture.(1) The disease can be graded as severe, moderate or mild and, ...
Ellwanger Kornelia - - 2013
The cellular functions of the serine/threonine protein kinase D (PKD) have been extensively studied within the last decade and distinct roles such as fission of vesicles at the Golgi compartment, coordination of cell migration and invasion, and regulation of gene transcription have been correlated with this kinase family. Here, we ...
Vasileiadis Ioannis - - 2013
Symmetrical lipomatosis of the tongue is an extremely rare condition. To date, only eight cases have been reported in the literature. We present an extremely rare case of intramuscular lipomatosis of the tongue in a 67-year-old male. The present case is unique because of its infiltrating nature and the extension ...
Kim S H - - 2013
BACKGROUND: Complication rates of living-donor right hepatectomy remain a matter of major concern. The aim of this study was to achieve near-zero morbidity for living-donor right hepatectomy in a single centre. METHODS: All living donors who underwent right hepatectomy between January 2005 and September 2011 were enrolled in this retrospective ...
Lee Gyunghee - - 2013
Dysfunctional regulation of brain dopamine (DA) functions has been found in patients with drug addiction and various neurological disorders that frequently accompany disturbance in sleep behavior. In this study, the roles of the dopaminergic nervous system on the regulation of daily locomotor activity rhythm were investigated in Drosophila melanogaster. Reduced ...
de Ciuceis Carolina - - 2013
It is not known whether, in obesity, the capillary density or the number of circulating endothelial progenitor cells (EPCs) are reduced, or whether fibrosis of small vessels is also present. In addition, possible effects of weight reduction on these parameters have never been evaluated. Therefore, we investigated EPCs and capillary ...
Armigliato Aldo - - 2013
A method for the fabrication of a wedge-shaped thin NiO lamella by focused ion beam is reported. The starting sample is an oxidized bulk single crystalline, ⟨100⟩ oriented, Ni commercial standard. The lamella is employed for the determination, by analytical electron microscopy at 200 kV of the experimental k(O-Ni) Cliff-Lorimer ...
Gering F - - 2013
The Fukushima accident led to high radionuclide releases into the atmosphere for more than 3 weeks. This situation has not been assumed when the concepts of nuclear emergency preparedness were developed internationally. The results of simulations studying potential implications of Fukushima-like source terms on nuclear emergency preparedness are presented. Two ...
Romero Jennifer V - - 2013
Impregnated activated carbons (IAC) are widely used materials for the removal of toxic gases in personal respiratory protection applications. The combinatorial method has been employed to prepare IACs containing different types of metal oxides in various proportions and evaluate their adsorption performance for low molecular weight gases such as SO2 ...
Pessach Ilias - - 2013
BACKGROUNDHematopoietic growth factors (HGFs) are mostly used as supportive measures to reduce infectious complications associated with neutropenia. Over the past decade, the use of HGFs became a common method for mobilizing human CD34+ stem cells, either for autologous or allogeneic transplantation. However, since their introduction the long-term safety of the ...
Yu Dong-Jun - - 2013
Understanding the interactions between proteins and ligands is critical for protein function annotations and drug discovery. We report a new sequence-based template-free predictor (TargetATPsite) to identify the Adenosine-5'-triphosphate (ATP) binding sites with machine-learning approaches. Two steps are implemented in TargetATPsite: binding residues and pockets predictions, respectively. To predict the binding ...
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