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Results 401 - 450 of 3304
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Talipov Marat R - - 2013
HOON might be an elusive intermediate of atmospheric photochemical reactions of HONO or recombination of the parent nitrene HN and molecular oxygen. However, no reliable data on HOON structure and stability are available, and the nature of the O-O bond is not well understood. In this study, we used high-level ...
Nielsen Jakob V - - 2013
Hippocampal pyramidal neurons are important for encoding and retrieval of spatial maps and episodic memories. While previous work has shown that Zbtb20 is a cell fate determinant for CA1 pyramidal neurons, the regulatory mechanisms governing this process are not known. In this study, we demonstrate that Zbtb20 binds to genes ...
Cole Scott N - - 2013
Abstract Patient MW, a known confabulator, and healthy age-matched controls produced past and future events. Events were judged on emotional valence and plausibility characteristics. No differences in valence were found between MW and controls, although a positive emotional bias toward the future was observed. Strikingly, MW produced confabulations about future ...
Liimakka Satu - - 2013
Drawing on focus group discussions, this article explores how young, Finnish university students view the cultural ideals of health and appearance. The young adults noted how body practices aiming at health can turn into unhealthy obsessions. As a result, a healthy-looking body may serve to cover an underlying body image ...
Lo Yu-Lun - - 2013
Polyethylenimine (PEI) is one of the most potent synthetic gene delivery vectors because of its high transfection efficiency. Although PEI has been used as a delivery vehicle for a long while, its toxicity is always an issue for clinical applications. In this study, we introduced a low molecular weight PEI ...
Edwards A C AC Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298-0126, USA. - - 2013
Alcohol consumption is influenced by genetic factors. Previous studies have examined the heritability of alcohol consumption, or related phenotypes, from adolescence into adulthood, frequently finding that total heritability changes over time. However, it remains unclear whether the same genes underlie liability to alcohol consumption across development versus whether novel risk ...
Tzenov Youlian R - - 2013
The human papillomavirus (HPV) is the etiologic agent of cervical cancer. In this study, we provide evidence for the human Pygopus (hPygo)2 gene as a cellular biomarker for HPV-related disease. In a tumor microarray of cervical cancer progression, hPygo2 levels were greater in high-grade lesions and squamous cell carcinomas than ...
Dimke Henrik - - 2013
Kidney stones are a prevalent clinical condition imposing a large economic burden to the healthcare system. Hypercalciuria remains the major risk factor for development of a Ca(2+)-containing stone. The kidney's ability to alter Ca(2+) excretion in response to changes in serum Ca(2+) is in part mediated by the Ca(2+)-sensing receptor ...
Corvalán Camila - - 2013
In low-birth-weight girls, obesity increases the risk of premature adrenarche and metabolic complications. However, the consistency of this association in normal-birth-weight children and its potential mediators remain unknown. The objectives were to assess the associations between obesity indicators and dehydroepiandrosterone sulfate (DHEAS) at 7 y of age and to evaluate ...
Maison Stéphane F SF Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, USA. - - 2013
Cholinergic inhibition of cochlear hair cells via olivocochlear (OC)-efferent feedback is mediated by Ca(2+) entry through α9-/α10-nicotinic receptors, but the nature of the K(+) channels activated by this Ca(2+) entry has been debated (Yoshida N, Hequembourg SJ, Atencio CA, Rosowski JJ, Liberman MC. J Neurophysiol 85: 84-88, 2001). A recent ...
García Felipe - - 2013
Combination antiretroviral therapy (cART) greatly improves survival and quality of life of HIV-1-infected patients; however, cART must be continued indefinitely to prevent viral rebound and associated disease progression. Inducing HIV-1-specific immune responses with a therapeutic immunization has been proposed to control viral replication after discontinuation of cART as an alternative ...
Soheilian Masoud M - - 2013
Abstract Purpose: To describe the course of inflammation and identify predictors of successful outcome in chronic endogenous/autoimmune uveitic patients following 25-gauge vitrectomy. Methods: In this retrospective study, charts of 74 patients (74 eyes) undergoing vitrectomy for complicated uveitis that had a minimum of 12 months follow-up were reviewed. Successful outcome ...
West Nick E J - - 2013
Patients presenting with acute coronary syndromes (ACS) remain amongst the highest-risk of all acute medical admissions. Despite significant reductions in morbidity and mortality via refinements in treatment methods in recent years, such individuals remain at a high risk of recurrent ischaemic events and death. Whilst 2012 has brought a wealth ...
Brown Dusty B DB Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Rd., Athens, GA 30602, - - 2013
An unusual α-(1,1)-galacturonic acid (GalA) lipid A modification has been reported in the lipopolysaccharide of a number of interesting Gram-negative bacteria, including the nitrogen-fixing bacteria Azospirillum lipoferum, Mesorhizobium huakuii and M. loti, the stalk-forming bacterium Caulobacter crescentus and the hyperthermophilic bacterium Aquifex aeolicus. However, the α-(1,1)-GalA transferase (GalAT) gene, which ...
Buck Harleah G HG School of Nursing, The Pennsylvania State University, University Park, PA 16802 , USA. - - 2013
Nurse researchers are exploring new ways of understanding heart failure (HF), spousal/partner dyad's self care. To assess the response to a new instrument developed to measure dyadic HF care type in HF patients and spousal/partner caregivers and explore relationships between type and other variables. Dyads answered a written criterion referenced ...
Freisinger Wolfgang - - 2013
Sensory neurons with afferent axons from the kidney are extraordinary in their response to electrical stimulation. More than 50% exhibit a tonic firing pattern i.e. sustained action potential firing throughout depolarizing, pointing to an increased excitability, whereas non-renal neurons show mainly a phasic response, i.e. <5 action potentials. Here we ...
Loft Shayne - - 2013
Remembering to perform deferred actions when an event is encountered in the future is referred to as event-based prospective memory (PM). We examined whether the failure of individuals to allocate sufficient attentional resources to nonfocal PM tasks can be linked to the response demands inherent in PM paradigms that require ...
Zhu Qiyun - - 2013
The promotion of membrane fusion by most paramyxoviruses requires an interaction between the viral attachment and fusion (F) proteins to enable receptor binding by the former to trigger the activation of the latter for fusion. Numerous studies demonstrate that the F-interactive sites on the Newcastle disease virus (NDV) hemagglutinin-neuraminidase (HN) ...
Edwards Ben J - - 2013
Muscle force production and power output in active males, regardless of the site of measurement (hand, leg, or back), are higher in the evening than in the morning. This diurnal variation is attributed to motivational, peripheral and central factors, and higher core and, possibly, muscle temperatures in the evening. This ...
De Soumen Das - - 2013
Upper-extremity-specific disability correlates with mood and coping strategies. The aim of this study was to determine if two psychological factors, kinesiophobia (fear of movement) and perceived partner support, contribute significantly to variation in upper-extremity-specific disability in a model that included factors known to contribute to variation such as depression, pain ...
Jeon Tae Yoon - - 2013
Large-area, highly ordered, Ag nanostructured arrays with various geometrical features were prepared for use as surface-enhanced Raman scattering (SERS)-active substrates by the self-assembly of inorganic particles on an SU-8 surface, followed by particle embedding and Ag vapor deposition. By adjusting the embedding time of the inorganic particles, the size of ...
Friesland Amy - - 2013
Signaling through the Rho family of small GTPases has been intensely investigated for its crucial roles in a wide variety of human diseases. Although RhoA and Rac1 signaling pathways are frequently exploited with the aid of effective small molecule modulators, studies of the Cdc42 subclass have lagged because of a ...
Gu Zhaolin - - 2013
Immovable historical relics in some archaeology museums of China suffer deterioration due to their improper preservation environment. The existing environmental control systems used in archaeology museums are often designed for the amenities of visitors; and these manipulated environments are often inappropriate for the conservation of abiotic relics. This paper points ...
Li Jiarui - - 2013
Cell aggregation in unicellular organisms, induced by either cell non-sexual adhesion to yield flocs and biofilm, or pheromone-driving sexual conjugation is of great significance in cellular stress response, medicine, and brewing industries. Most current literatures have focused on one form of cell aggregation termed flocculation and its major molecular determinants, ...
Zhang Tengyue - - 2013
ABSTRACT: BACKGROUND: Mounting evidence has suggested that plasminogen activator inhibitor-1 (PAI-1) is a candidate for increased risk of diabetic retinopathy. Studies have reported that insertion/deletion polymorphism in the PAI-1 gene may influence the risk of this disease. To comprehensively address this issue, we performed a meta-analysis to evaluate the association ...
Ran Xiang - - 2013
We demonstrate a novel, rapid and label-free assay for the detection of Ag(+) and biothiols with high sensitivity and selectivity by utilization of Ag nanoparticle-decorated graphene quantum dots.
Cortez Leonardo M LM Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta T6G 2M8, - - 2013
Prion diseases are fatal neurodegenerative disorders associated with the polymerization of the cellular form of prion protein (PrP(C)) into an amyloidogenic β-sheet infectious form (PrP(Sc)). The sequence of host PrP is the major determinant of host prion disease susceptibility. In mice, the presence of allele a (Prnp(a), encoding the polymorphism ...
Singh Rajesh K RK Molecular Medicine, National Heart and Lung Institute, Imperial College London, London, - - 2013
Mediator release from mast cells is a critical step in allergic and inflammatory disease. However, the processes regulating the latter stages of granule release are yet to be fully understood. Rab27 small GTPases regulate release of secretory lysosomes in a variety of cells, including mast cell granules. In the present ...
Yang Jui-Jung - - 2013
Intracapsular femoral neck fractures are associated with high rates of nonunion. We aimed to identify risk factors for nonunion in patients with both displaced and nondisplaced intracapsular femoral neck fractures treated with three 7-mm parallel cannulated screws, placed in either a triangle or an inverted triangle configuration, using failure of ...
Born Stephan - - 2013
Bitter taste is a basic taste modality, required to safeguard animals against consuming toxic substances. Bitter compounds are recognized by G-protein-coupled bitter taste receptors (TAS2Rs). The human TAS2R10 responds to the toxic strychnine and numerous other compounds. The mechanism underlying the development of the broad tuning of some TAS2Rs is ...
Fang Yin - - 2013
We report a new solution-deposition method to synthesize an unprecedented type of two-dimensional (2D) ordered mesoporous carbon nanosheets, via a controlled low-concentration monomicelle close packing assembly approach. These obtained carbon nanosheets possess only one layer of ordered mesopores laid on the surface of a substrate, typically the inner walls of ...
Schwarzkopf Ran - - 2013
Knee malalignment during total knee arthroplasty (TKA) is commonly classified as either varus or valgus on the basis of a standing anteroposterior radiograph. Computer-assisted surgery (CAS) navigation TKA provides precise dynamic evaluation of knee alignment throughout the full range of motion (FROM). The goal of this study was to classify ...
Mochida Keiichi - - 2013
Crop plants, whose productivity is affected by a wide range of growing and environmental conditions, are grown for economic purposes. Transcription factors (TFs) play central role in regulation of many biological processes, including plant development and responses to environmental stimuli, by activating or repressing spatiotemporal gene expression. Here, we describe ...
Gómez-Tortosa Estrella - - 2013
OBJECTIVE: Expansions of more than 30 hexanucleotide repetitions in the C9ORF72 gene are a common cause of frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS). However, the range of 20-30 repetitions is rarely found and still has unclear significance. A screening of our cohort of cases with FTD (n = ...
Beneyton T - - 2013
We developed a new covalent enzyme immobilization technique compatible with lithography processes. Carbon nanotube electrodes patterned on glass slides were used to create Y-shaped membraneless glucose/O(2) microfluidic biofuel cells. An original extremophilic laccase, CotA from Bacillus subtilis, was used in the cathodic compartment of these miniaturized biofuel cells.
Manning Lydia K - - 2013
Research suggests that spirituality is important to a large percentage of the older adult population and serves as a promoter of healthy aging. In this qualitative research I conducted and analyzed multiple interviews with 6 women aged 80 and older. Using multiple in-depth interviews I explored the interplay between spirituality ...
Shamsher Areeg A - - 2013
Abstract The focus of the present study was to develop and evaluate the transdermal system of celecoxib. Transdermal gels composed of carbopol 940 in propylene glycol (PG) containing penetration enhancers. The formulations were characterized by permeation, pharmacokinetics, pharmacodynamics and histopathology. Celecoxib permeation across excised rat skins were statistically (p < 0.05) enhanced ...
Lemke Henrik T - - 2013
X-ray Free Electron Lasers (XFELs) deliver short (<100 femtoseconds) and intense (~1e12 photons) pulses of hard X-rays making them a perfect source for time resolved studies. Here we show that, despite the inherent instabilities of current XFELs, they can be used for measuring high quality X-ray absorption data and we ...
Mota Theo - - 2013
Color vision in honey bees (Apis mellifera) has been extensively studied at the behavioral level and, to a lesser degree, at the physiological level by means of electrophysiological intracellular recordings of single neurons. Few visual neurons have been so far characterized in the lateral protocerebrum of bees. Therefore, the possible ...
Thomases Daniel R - - 2013
A developmental disruption of prefrontal cortical inhibitory circuits is thought to contribute to the adolescent onset of cognitive deficits observed in schizophrenia. However, the developmental mechanisms underlying such a disruption remain elusive. The goal of this study is to examine how repeated exposure to the NMDA receptor antagonist dizocilpine maleate ...
Piantoni Giovanni - - 2013
The characteristic oscillations of the sleeping brain, spindles and slow waves, show trait-like, within-subject stability and a remarkable interindividual variability that correlates with functionally relevant measures such as memory performance and intelligence. Yet, the mechanisms underlying these interindividual differences are largely unknown. Spindles and slow waves are affected by the ...
Rossin Andrea - - 2013
Catalytic dehydrogenation of ammonia-borane (NH(3)·BH(3), AB) and dimethylamine borane (NHMe(2)·BH(3), DMAB) by the Pd(II) complex [((tBu)PCP)Pd(H(2)O)]PF(6) [(tBu)PCP = 2,6-C(6)H(3)(CH(2)P(t)Bu(2))(2)] leads to oligomerization and formation of spent fuels of general formula cyclo-[BH(2)-NR(2)](n) (n = 2,3; R = H, Me) as reaction byproducts, while one equivalent of H(2) is released per amine-borane ...
Machens Andreas A Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube-Strasse 40, D-06097 Halle (Saale), Germany. - - 2013
In multiple endocrine neoplasia type 2, American Thyroid Association (ATA) management guidelines recommend continuous biochemical screening for pheochromocytoma and/or primary hyperparathyroidism. This implicit assumption of linear tumor development is difficult to reconcile with current thinking that cells accrue somatic mutations stochastically, yielding a bell-shaped distribution. This investigation aimed at evaluating ...
Patinha Daniela D Uppsala Univ., Dept. of Medical Cell Biology, Biomedical Center, Box 571, 751 23 Uppsala, - - 2013
Increased angiotensin II (ANG II) or adenosine can potentiate each other in the regulation of renal hemodynamics and tubular function. Diabetes is characterized by hyperfiltration, yet the roles of ANG II and adenosine receptors for controlling baseline renal blood flow (RBF) or tubular Na(+) handling in diabetes is presently unknown. ...
Cox Jason R - - 2013
Photoalignment of nematic liquid crystals is demonstrated using a di-π-methane rearrangement of a designed polymer. The alignment mechanism makes use of the strong coupling of the liquid crystal directors to dibenzobarrelene groups. The large structural changes that accompany photoisomerization effectively passivate segments of the polymer, allowing the remaining dibenzobarrelene groups ...
Jiang Wei - - 2013
Influenza A virus is an important pathogenic virus known to induce host cell cycle arrest in G(0)/G(1) phase and create beneficial conditions for viral replication. However, how the virus achieves arrest remains unclear. We investigated the mechanisms underlying this process and found that the nonstructural protein 1 (NS1) is required. ...
Hughes Joseph D - - 2013
To evaluate the use of general-purpose graphics processing units (GPGPUs) to improve the performance of MODFLOW, an unstructured preconditioned conjugate gradient (UPCG) solver has been developed. The UPCG solver uses a compressed sparse row storage scheme and includes Jacobi, zero fill-in incomplete, and modified-incomplete lower-upper (LU) factorization, and generalized least-squares ...
Li Yi - - 2013
The huge pool of hypothetical zeolites can be screened for likely candidates for successful targeted synthesis on the basis of a set of reliable criteria derived from the observation that the local interatomic distances in all existing zeolites strictly obey several rules. For example, the average TT and TO distances ...
Andersen Jaron R - - 2013
We reviewed a consecutive series of patients with a humeral fracture around either an anatomic or a reverse shoulder prosthesis treated with either open reduction and internal fixation (ORIF) or revision shoulder arthroplasty. The purposes of the study were to (1) describe the treatment of these fractures by either method, ...
Carter Gerald G GG Department of Biology, University of Maryland, College Park, MD 20742, USA. - - 2013
Common vampire bats often regurgitate food to roost-mates that fail to feed. The original explanation for this costly helping behaviour invoked both direct and indirect fitness benefits. Several authors have since suggested that food sharing is maintained solely by indirect fitness because non-kin food sharing could have resulted from kin ...
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