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Nusca Annunziata - - 2013
Single antiplatelet therapy with aspirin is actually recommended for cardiovascular prevention in patients with stable coronary disease, whereas dual antiplatelet therapy (aspirin and clopidogrel) represents the established treatment in patients with acute coronary syndromes or stable angina undergoing percutaneous coronary intervention. However, recurrent ischemic events occur in patients on treatment ...
Kuze J - - 2013
Abstract 1. To search an appropriate evaluation methodology for the intestinal first-pass metabolism of new drug candidates, grapefruit juice (GFJ)- and vehicle (tap water)-pretreated mice or rats were orally administered midazolam (MDZ) or triazolam (TRZ), and blood levels of the parent compounds and their metabolites were measured by liquid chromatography/MS/MS. ...
Troupis John M - - 2013
Cardiac CT myocardial perfusion is an emerging tool utilizing differences in myocardial density of ischemic compared to normal myocardium. We sought to document the contrast enhanced density profile of myocardial segments subtended by severely stenotic coronary arteries on rest (non stress) cardiac CT imaging, and compare the density with identical ...
Sirisha K - - 2013
This study was carried out to compare the post-thaw cryosurvival rate and the level of apoptosis in vitro produced zona-free cloned buffalo blastocysts subjected to slow freezing or vitrification in open-pulled straws (OPS). Zona-free cloned embryos produced by handmade cloning were divided into two groups and were cryopreserved either by ...
Westin Anna M L - - 2013
Prolonged waiting times to receive mental health services are common and may have negative consequences. This study examines the relationship between waiting time and treatment engagement among 2,054 youth referred to an evidence based treatment (EBT). Findings indicate that families are more likely to refuse services if they face longer ...
Smith Elliot - - 2013
Objective. Hierarchical processing of auditory sensory information is believed to occur in two streams: a ventral stream responsible for stimulus identity and a dorsal stream responsible for processing spatial elements of a stimulus. The objective of the current study is to examine neural coding in this processing stream in the ...
Lin Hsiang-Ru - - 2013
Paeoniflorin is one of the active ingredients of Paeonia lactiflora Pall., a novel traditional herbal medicine exerting pharmacological effects including antihyperlipidemic, neuroprotective, and anti-hepatofibrosis effects. Liver X receptor (LXR) acts as a ligand-activated transcription factor to exhibit antihyperlipidemic and neuroprotective effects. In this study, the activity of paeoniflorin against LXR ...
Curfman Gregory D - - 2013
To provide good care, physicians must understand the communities and cultures in which they work. An important way to ensure that physicians understand the lives of their patients and to reduce health disparities is to promote racial and ethnic diversity in the physician workforce. However, a crucial tool that has ...
He Hui-Chan - - 2013
The ErbB3 binding protein 1 (Ebp1) represents a downstream effector of the ErbB signaling network and has been demonstrated to be a potent tumor suppressor in various human malignancies, however, its involvement in human bladder cancer is still unclear.To investigate the clinical significance and potential role of ErbB3 binding protein ...
Cools S - - 2013
In the present study, we analysed the effect of fixative, breed, luteal stage and location on the nuclear density, volume density of connective tissue and vascular tissue/lumina within a bovine luteal gland in view of the development of an in vivo sampling technique to longitudinally monitor luteal histophysiology. The inner ...
Rosa Mendoza Erick Sta - - 2013
BACKGROUND: Breast cancer is a clinically heterogeneous disease. Approximately 10-15 % of breast cancer patients develop distant metastases within 2 years of diagnosis with a poor 5-year survival rate of 21 %. Little data have been gathered about how some breast cancer metastasizes earlier than expected. The study aimed to identify predictors of ...
- - 2013
To the Editor: In the study by Thiele et al. (Oct. 4 issue)(1) on the use of intraaortic balloon counterpulsation (IABP) in patients with cardiogenic shock caused by acute myocardial infarction, the authors' conclusion that IABP did not significantly reduce 30-day mortality has to be taken with caution. In one ...
Gude Tore - - 2013
Objectives. To investigate the relationship between the length of a medical consultation in a general practice setting and the biopsychosocial information obtained by the physician, and to explore the characteristics of young physicians obtaining comprehensive, especially psychosocial information. Design. A prospective, longitudinal follow-up study. Setting. Videotaped consultations with standardized patients ...
You Yu - - 2013
Background/Aims: This study aims to summarize the diagnosis and management experience of adult choledochal cyst (CC) patients and highlights our experience of reoperation cases. Methodology: The clinical data of 65 adult patients with CCs at the Second Affiliated Hospital of Chongqing Medical University between 2007 and 2011 were analyzed retrospectively. ...
Lingwood Mark D - - 2013
We compare diffusion activation energy measurements in a hydrated perfluorosulfonate ionomer and aqueous solutions of triflic acid. These measurements provide insight into water transport dynamics on sub-nm length scales, and gauge the contribution of the polymer sidechain terminal group. Future membrane materials design will hinge on detailed understanding of transport ...
Quigley A F - - 2013
Injury to nerve tissue in the peripheral nervous system (PNS) results in long-term impairment of limb function, dysaesthesia and pain, often with associated psychological effects. Whilst minor injuries can be left to regenerate without intervention and short gaps up to 2 cm can be sutured, larger or more severe injuries commonly ...
- - 2013
To the Editor: Thigpen et al. (Aug. 2 issue)(1) report that persons who are seronegative for the human immunodeficiency virus (HIV) and who are receiving tenofovir disoproxil fumarate and emtricitabine (TDF-FTC) for preexposure prophylaxis had decreased bone mineral density at 24 months, as compared with those receiving placebo. In HIV-infected ...
Ibata Rodrigo A - - 2013
Dwarf satellite galaxies are thought to be the remnants of the population of primordial structures that coalesced to form giant galaxies like the Milky Way. It has previously been suspected that dwarf galaxies may not be isotropically distributed around our Galaxy, because several are correlated with streams of H I emission, ...
Crutchfield Christopher A CA National Institutes of Health, Bethesda, MD 20892, - - 2013
We have developed new applications of the pseudocolor plot for the analysis of LC/MS data. These applications include spectral averaging, analysis of variance, differential comparison of spectra, and qualitative filtering by compound class. These applications have been motivated by the need to better understand LC/MS data generated from analysis of ...
Josefson J L JL Division of Endocrinology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois 60611-2605, USA. - - 2013
More than 40% of women with a normal pre-pregnancy body mass index (BMI) exceed the 2009 Institute of Medicine (IOM) guidelines' recommended weight gain of 25-35 lb. Excessive gestational weight gain is one modifiable factor that may be contributing to childhood overweight and obesity. The objective of this study was to ...
Friedman Joseph H - - 2013
Abstract Background: The glabellar reflex (GR) is often interpreted as a clinical measure of parkinsonism although data to support this are weak. It is one of ten items used in the Simpson Angus Scale, a popular measure of parkinsonism in psychiatric studies of neuroleptic drugs. We hypothesized that the GR ...
Cho Youngnam - - 2013
The development of a target-activatable "smart" platform with high-affinity and specificity is of great importance for a wide range of biomedical applications. Here, we attempted to develop a new enzyme-activatable graphene oxide-photosensitizer complex as a biologically tunable theranostic agent, making it promising for near-infrared (NIR) fluorescence imaging and photo-induced cancer ...
Huot Philippe P Baycrest Centre for Geriatric Care, Toronto, ON, - - 2013
L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia is a complication of dopaminergic treatment in Parkinson's disease. Lowering the L-DOPA dose reduces dyskinesia but also reduces the antiparkinsonian benefit. A therapy that could enhance the antiparkinsonian action of low-dose L-DOPA (LDl) without exacerbating dyskinesia would thus be of considerable therapeutic benefit. This study assessed whether ...
Sarkhosh Maryam - - 2013
Identifying the sources of volatile organic compounds (VOCs) is key issue to reducing ground-level ozone and PAN. A multivariate receptor model (Unmix) was used for the determination of the contributions of VOCs sources in Tehran-Iran. Concentrations of ambient C(2)-C(10) VOCs were measured continuously and online at the center of Tehran ...
Leng Siyang - - 2013
A 44-year-old man presented to the emergency department with chest pain that had started 1 hour earlier and had awakened him from sleep. The pain was severe, substernal, burning, radiating to the left arm, and accompanied by nausea and vomiting.
van den Berg G - - 2013
BACKGROUND: Body mass index (BMI) does not make a distinction between fat mass and lean mass. In children, high fat mass appears to be associated with low maternal education, as well as low lean mass because maternal education is associated with physical activity. Therefore, BMI might underestimate true obesity in ...
Cheng Li-Kun - - 2013
Optimum production of L-tryptophan by Escherichia coli depends on pH. Here, we established conditions for optimizing the production of L-tryptophan. The optimum pH range was 6.5-7.2, and pH was controlled using a three-stage strategy [pH 6.5 (0-12 h), pH 6.8 (12-24 h), and pH 7.2 (24-38 h)]. Specifically, ammonium hydroxide was used to ...
Buoli Massimiliano - - 2013
Selective serotonin reuptake inhibitors (SSRIs) and serotonine reuptake Inhibitors (SNRIs) together with pregabalin are actually considered by international guidelines as the first-line choice for generalized anxiety disorder (GAD) treatment. However, 50% of GAD patients have poor response to first-line treatments and different molecules, such as atypical antipsychotics and mood stabilizers, ...
Jiang Feng - - 2013
Size-controllable amine-functionalized graphene quantum dots (GQDs) are prepared by an eco-friendly method with graphene oxide sheets, ammonia and hydrogen peroxide as starting materials. Using a Sephadex G-25 gel column for fine separation, for the first time we obtain GQDs with either single or double layers. By atomic force microscopy characterization, ...
Motamedi Mahmood - - 2013
The aim of the current study was to evaluate for the first time the hippocampal changes in patients with pure sleep and pure waking epilepsy. A total of 35 patients with pure partial onset sleep epilepsy and 35 patients with pure partial onset waking epilepsy matched for age and sex ...
Kråkvik Bodil - - 2013
Kråkvik, B., Stiles, T. & Hugdahl, K. (2013). Experiencing malevolent voices is associated with attentional dysfunction in psychotic patients. Scandinavian Journal of Psychology. Inattention in people with schizophrenia is common. However, there has been little research on the association between inattention and auditory hallucinations. The aim of the study was ...
Fallon Sara C - - 2013
BACKGROUND: The contemporary management of children with ileocolic intussusception often includes pneumatic reduction. While failure of the procedure or recurrence after reduction can result in the need for surgical treatment, more serious adverse sequelae can occur including perforation and, rarely, tension pneumoperitoneum. During the last year, four cases of perforation ...
Poordad Fred - - 2013
There is a need for interferon-free treatment regimens for hepatitis C virus (HCV) infection. The goal of this study was to evaluate ABT-450, a potent HCV NS3 protease inhibitor, combined with low-dose ritonavir (ABT-450/r), in addition to ABT-333, a nonnucleoside NS5B polymerase inhibitor, and ribavirin, for the treatment of HCV ...
- - 2013
To the Editor: Redelmeier et al. (Sept. 27 issue)(1) report the association between physicians' warnings to unfit drivers and a significant increase in patients' depression, as measured by the rate of emergency department visits for depression. Driving cessation has been correlated with increased depressive symptoms(2) and social isolation(3) and a ...
Boattini Alessio - - 2013
East Africa (EA) has witnessed pivotal steps in the history of human evolution. Due to its high environmental and cultural variability, and to the long-term human presence there, the genetic structure of modern EA populations is one of the most complicated puzzles in human diversity worldwide. Similarly, the widespread Afro-Asiatic ...
Hou Gonglin - - 2013
The structural asymmetry of bilateral hippocampus in mammals has been well recognized. Recent findings highlighted the accompanying functional asymmetries, as well as the molecular differences of the hippocampus. The present paper summarized these recent advances in understanding the hippocampal asymmetries at molecular, circuit and functional levels. Additionally, the addition of ...
Troiani Teresa - - 2013
A number of anti-EGFR monoclonal antibodies (mAbs) have been recently developed for the treatment of refractory metastatic colorectal cancer (mCRC). These mAbs, blocking ligand/receptor interactions, exert their biological activity via multiple mechanisms, including inhibition of cell cycle progression, potentiation of cell apoptosis, inhibition of angiogenesis, tumor cell invasion and metastasis ...
Ahlén Gerd Carlsson - - 2013
Objective. To study whether the physician's evaluation of the consultation correlates to patient outcome one month later concerning symptom relief, sick leave, and drug compliance as perceived by the patient. The study also investigated whether the patient's evaluation of the consultation correlated to patient outcome. Design. A longitudinal study using ...
Chen Dong - - 2013
We evaluate the safety, efficacy, and oncological outcomes of early palliative photoselective vaporization of the prostate (PVP) by GreenLight high-performance system (HPS) 120-W laser in patients with acute urinary retention (AUR) induced by advanced prostate cancer (PCa). A total of 39 advanced PCa patients with AUR who underwent PVP were ...
Kuranchie-Mensah Harriet - - 2013
The study was carried out to determine the levels of organochlorine pesticide residue in five fish species Chrysichthys nigrodigitatus, Hepsetus odoe, Tilapia zilli, Heterotis niloticus and Oreochromis niloticus from the Densu river basin (Weija) in Ghana. The fishes sampled from the Weija fish landing site were selected on the basis ...
Aguilera-Luiz Maria M - - 2013
A simple and rapid method is described for the determination of veterinary drug (VD) residues in honey samples using turbulent flow chromatography coupled to ultra-high performance liquid chromatography-Orbitrap mass spectrometry (TFC-UHPLC-Orbitrap-MS). Honey samples were diluted with an aqueous solution of Na2EDTA (0.1 M). Then, they were injected into the chromatographic ...
Salonia Andrea - - 2013
PURPOSE: We sought whether serum total testosterone (tT), estradiol (E(2)), tT/E(2) ratio, and sex hormone-binding globulin (SHBG) significantly fluctuate throughout time in men with prostate cancer (PCa). METHODS: Circulating hormones were measured in a cohort of 631 candidates for radical prostatectomy. Hormone levels were analyzed according to either patient age, ...
Rodríguez Nelson A - - 2013
A 29-year-old man presented with blurred vision, photophobia, and pain after trauma to his left eye caused by a screwdriver. He had a history of moderate myopia (visual acuity, 20/25) and had undergone uneventful bilateral laser-assisted in situ keratomileusis (LASIK) 10 years previously. On examination, he had a 180-degree traumatic ...
Kumar Mukesh - - 2013
Formation of cyclic intermediates involving water or ammonia loss is a common occurrence in any reaction involving terminal amines or hydroxyl group containing species. Proteins that have both these functional groups in abundance are no exception, and presence of amino acids such as asparagine, glutamines, aspartic acids, and glutamic acids ...
Murakami Daiki - - 2013
The wetting behavior of superhydrophilic polyelectrolyte brushes was investigated. Reflection interference contrast microscopy demonstrated that the contact angles of water on the polyelectrolyte brushes were extremely low but remained finite in the range of < 3°. The presence of water molecules was evident, even outside the macroscopic water droplet. These ...
Li He - - 2013
The impact of pollutants from road runoff on receiving water bodies becomes increasingly serious. However, less is known about the study on the distribution of metal speciation in particles with different sizes, and the interaction among metal speciation. Our research is aimed at investigating speciation distribution of copper (Cu) and ...
Hamwieh A - - 2013
A recombinant inbred line (RIL) population, comprising 181 lines derived from ILC588 × ILC3279, was evaluated in 10 environments across three locations with different moisture gradients. A drought resistance score (DRS) and three phenology traits-plant height (PLHT), days to flowering (DFLR), and days to maturity (MAT)-were recorded along with seven yield-related traits-grain ...
Collinge Mark - - 2013
Abstract Establishing an in vivo cell-mediated immunity (CMI) assay, such as the delayed-type hypersensitivity (DTH) assay, has been identified as an important gap and recommended to receive highest priority for new model development in several workshops on developmental immunotoxicity. A Candida albicans DTH model has recently been developed that has ...
Dahdaleh Fadi S - - 2013
BACKGROUND: Neuroendocrine tumors of the small bowel (SBNETs) are a rare but important subgroup of malignancies. Since 30 % of SBNETs present with metastatic disease, often with an occult primary, preoperative imaging is critical for determining who will benefit most from abdominal exploration. We set out to evaluate the usefulness of ...
- - 2013
A Tickling in the Ear (September 20, 2012;367:e17). In the second and third sentences (page e17), "tick" should have been "bug." Also, several sentences should not have been included: the sixth sentence, beginning "The tick was identified . . ."; the sentence that follows, beginning "This tick can serve"; and ...
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