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Kim C H - - 2013
PURPOSE: Pulmonary tuberculosis (PTB), with a tuberculosis (TB)-polymerase chain reaction (PCR)-negative bronchial aspirate (BA), but a positive culture result is often encountered in clinical practice. However, limited data are available concerning clinical judgment in patients with suspected PTB and a TB-PCR-negative BA pending culture results. The present study aimed to ...
Kappes Andreas - - 2013
Implicit theories of emotion-assumptions about whether emotions are fixed (entity theory) or malleable (incremental theory)-have previously been shown to influence affective outcomes over time. We examined whether implicit theories of emotion also relate to the immediate regulation of negative affect. Consistent with our hypotheses, we found that the more students ...
Christopher John A - - 2013
Application WO2012081692 from Taisho Pharmaceutical Co. Ltd. claims pyrazole-based antagonists of the orexin-1 and orexin-2 receptors. Utility in a number of therapeutic areas is claimed, including the treatment of sleep disorders; the most likely use of the claimed compounds. Data from in vitro functional assays are presented, with the claimed ...
Sundin Tabetha - - 2013
We previously demonstrated in prostate cancer cells that a phytochemical-perillyl alcohol-and the mechanistic target of rapamycin (mTOR) inhibitor rapamycin rapidly attenuated telomerase activity. Protein levels of the telomerase catalytic subunit reverse transcriptase (hTERT) were diminished in the absence of an effect on hTERT mRNA, supporting an effect on 4E-BP1 phosphorylation ...
Follin C - - 2013
Acute lymphoblastic leukaemia (ALL) is the most common childhood malignancy. The survival rate in the Scandinavian countries is now around 85 %. ALL patients treated with cranial radiotherapy (CRT) are at risk for growth hormone deficiency (GHD), but little is known about other pituitary insufficiencies, e.g. ACTH. Adult ALL patients (median ...
Graham Jennifer - - 2013
"Curricula-in-action" generally differ from "official" curricula. That is particularly true of clerkship curricula because the practising doctors who supervise medical students' clinical activities are only secondarily educators. Clerkship education is evaluated, however, according to benchmarks set by official curricula. As a result, clerkship evaluations are important points of contact between ...
A Reine Pål - - 2013
Background. The pharmacokinetics of the immunosuppressant mycophenolic acid (MPA) demonstrates high inter- and intra-patient variability. Variation in the binding of MPA to albumin has been postulated to be an important factor in this variability, and monitoring of free MPA has been suggested to improve therapeutic drug monitoring (TDM) of MPA. ...
Li Hongbo - - 2013
An indirect photoelectrochemical sensing platform for toxic hexavalent chromium was for the first time constructed based on its redox reaction with quercetin as both the electron donor and photosensitizer on a TiO(2) photoanode, and thus inhibiting the photocurrent quantitatively and selectively. The presence of even 500-fold coexisting Cr(iii) does not ...
Jessen Jan Peter - - 2013
PURPOSE: Aim of our study was to evaluate the results of percutaneous nephrolithotomy (PNL) with sonographic/fluoroscopic guided puncture during a learning curve and to compare them to an expert. METHODS: The first 75 consecutive patients undergoing conventional PNL or Mini-PNL by a novice percutaneous surgeon without direct supervision by an ...
Kleber Franz X - - 2013
To the Editor: In the study by Thiele et al. (Oct. 4 issue)(1) on the use of intraaortic balloon counterpulsation (IABP) in patients with cardiogenic shock caused by acute myocardial infarction, the authors' conclusion that IABP did not significantly reduce 30-day mortality has to be taken with caution. In one ...
Roggenkamp Dennis - - 2013
Atopic eczema is a chronic inflammatory skin disease characterized by cutaneous nerve fiber sprouting and epidermal hyperplasia, pointing to an involvement of the peripheral nervous system in cutaneous homeostasis. However, the interaction of sensory neurons and skin cells is poorly understood. Using an innervated skin model, we investigated the influence ...
Lee Taik Jong - - 2013
Among the many factors that affect the degree of completion and satisfaction of breast reconstruction, the scarring is one issue that a surgeon cannot completely control. We hypothesized that the administration of cytotoxic drugs following the immediate breast reconstruction using transverse rectus abdominis musculocutaneous (TRAM) flap might affect the process ...
Drake Emily - - 2013
The fear and stigma associated with postpartum depression (PPD) is a major challenge in the treatment of this disease. Our goal is to develop innovative methods of screening women for the symptoms of PPD to facilitate referral and treatment. This study explores the efficacy of the Internet in reaching out ...
Aboukhalid Rachid - - 2013
In an effort to facilitate forensic mitochondrial DNA (mtDNA) testing in Morocco, high-quality control region sequences from 509 individuals were generated using a comprehensive processing and data review system. This large dataset of random samples from various Moroccan population groups (Arab speaking, Berber speaking, and Sahrawi speaking) exhibited a low ...
Tomczyk Jacek - - 2013
In many odontological studies concerning archeological material, there is no analysis of early caries lesions (caries incipiens) that manifest as a carious spot. At this stage of caries, the enamel is still hard, and thus, it is impossible to diagnose caries by visual methods. We assessed the usefulness of the ...
Kato Naoki - - 2013
ABSTRACT: BACKGROUND: The physiological function of p38alpha, which is an isoform of p38 MAPK, has been investigated previously in several studies using pharmacological inhibitors. However, the results regarding whether p38alpha promotes or inhibits nerve regeneration in vivo have been controversial. METHODS: We generated novel p38alpha mutant mice (sem mice) with ...
Timm Jana - - 2013
ABSTRACT: BACKGROUND: If we initiate a sound by our own motor behavior, the N1 component of the auditory event-related brain potential (ERP) that the sound elicits is attenuated compared to the N1 elicited by the same sound when it is initiated externally. It has been suggested that this N1 suppression ...
Zhong Jingtao - - 2013
Background/Aims: To explore the significance of POSSUM scoring system (Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity) in predicting morbidity and mortality in elderly Chinese patients undergoing pancreatoduodenectomy (PD). Methodology: Between January 2001 and January 2011, 396 patients underwent PD in our hospital; POSSUM and P-POSSUM ...
Zhang Zhuomin - - 2013
Two novel polypyrrole (PPy) composite solid-phase microextraction (SPME) fiber coatings involving polypyrrole β-naphthalenesulfonic acid (PPy/β-NSA) and polypyrrole graphene (PPy/GR) composite SPME fiber coatings were prepared by a simple sol-gel technique for selectively sampling relatively polar biological volatile organic compounds (VOCs). Crucial preparation conditions of the PPy composite SPME fiber coatings ...
Dinkla Anna M - - 2013
Backgroun. Due to improved visibility on MRI, contouring of the prostate is improved compared to CT. The aim of this study was to quantify the benefits of using MRI for treatment planning as compared to CT-based planning for temporary implant prostate brachytherapy. Material and methods. CT and MRI image data ...
Hartl Dana M - - 2013
In the past two decades, major modifications in the way we treat head and neck cancers, due to advances in technology and medical oncology, have led to a decline in the use of open surgery as first-line treatment of cancers arising from several primary tumor sites. The incidence of tobacco- ...
Bauer Moisés E - - 2013
There is evidence suggesting that immunosenescence can be accelerated by external factors such as chronic stress. Here we review potential psychoneuroendocrine determinants of premature aging of the immune system and discuss available interventions aimed at attenuating immunosenescence. Chronic stress may accelerate various features of immunosenescence by activating key allostatic systems, ...
Fukumoto Yoshikazu - - 2013
Dentin hypersensitivity (DH) may be present in association with gingival recession. The aim of this study was to determine quantitatively the association of gingival recession and other factors with the presence of DH. One hundred and four Japanese subjects with or without gingival recession were randomly selected. Intact canines and/or ...
Ketabi Sepideh - - 2013
Due to the importance of soluble nanotubes in biological systems, computational research on DNA base functionalized nanotubes is of interest. This study presents the quantitative results of Monte Carlo simulations of Li-doped silicon carbide nanotubes and its nucleic acid base complexes in water. Each species was first modeled by quantum ...
Lech-Maranda Ewa - - 2013
The aim of this study was to verify whether pretreatment plasma levels of vascular endothelial growth factor (VEGF) correlate with prognosis and survival of patients with diffuse large B-cell lymphoma (DLBCL). Plasma VEGF levels were assessed at the time of diagnosis in 157 DLBCL patients treated with anthracycline-based chemotherapy. Plasma ...
Hall Kara L - - 2013
Pneumatic muscle actuators (PMAs) have a high power to weight ratio and possess unique characteristics which make them ideal actuators for applications involving human interaction. PMAs are difficult to control due to nonlinear dynamics, presenting challenges in system implementation. Despite these challenges, PMAs have great potential as a source of ...
Zhou Yu-Hao - - 2013
ABSTRACT: BACKGROUND: Fibrates has been extensively used to improve plasma lipid levels and prevent adverse cardiovascular outcomes. However, the effect of fibrates on stroke is unclear at the present time. We therefore carried out a comprehensive systematic review and meta-analysis to evaluate the effects of fibrates on stroke. METHODS: We ...
Gragnoli Claudia - - 2013
ABSTRACT: AIMS: Obesity and obesity-associated phenotypes are linked to the chromosome12q24 locus, the non-insulin-dependent-diabetes 2 (NIDDM2) locus. The gene of proteasome modulator 9 (PSMD9) lies in the NIDDM2 region and is linked to type 2 diabetes (T2D) and microvascular and macrovascular complications of T2D.We aimed at studying whether the PSMD9 ...
Latif Robabeh - - 2013
The objective of this study was to assess the capability of earthworms from the same ecological group as heavy metal bioindicators. Three earthworm species from the endogeic group were studied: Aporrectodea caliginosa (Savigny, 1826), Perelia kaznakovi (Michaelsen, 1910) and Octolasion lacteum (Örley, 1885). Their accumulation of the heavy metals lead ...
Moore Jennifer - - 2013
This article evaluates New Zealand's Medicines Amendment Bill 2011. This Bill is currently before Parliament and will amend the Medicines Act 1981. On June 20, 2011, the Australian and New Zealand governments announced their decision to proceed with a joint scheme for the regulation of therapeutic products such as medicines, ...
Curfman Gregory D - - 2013
To provide good care, physicians must understand the communities and cultures in which they work. An important way to ensure that physicians understand the lives of their patients and to reduce health disparities is to promote racial and ethnic diversity in the physician workforce. However, a crucial tool that has ...
He Hui-Chan - - 2013
The ErbB3 binding protein 1 (Ebp1) represents a downstream effector of the ErbB signaling network and has been demonstrated to be a potent tumor suppressor in various human malignancies, however, its involvement in human bladder cancer is still unclear.To investigate the clinical significance and potential role of ErbB3 binding protein ...
Cools S - - 2013
In the present study, we analysed the effect of fixative, breed, luteal stage and location on the nuclear density, volume density of connective tissue and vascular tissue/lumina within a bovine luteal gland in view of the development of an in vivo sampling technique to longitudinally monitor luteal histophysiology. The inner ...
Rosa Mendoza Erick Sta - - 2013
BACKGROUND: Breast cancer is a clinically heterogeneous disease. Approximately 10-15 % of breast cancer patients develop distant metastases within 2 years of diagnosis with a poor 5-year survival rate of 21 %. Little data have been gathered about how some breast cancer metastasizes earlier than expected. The study aimed to identify predictors of ...
Livi Lorenzo - - 2013
The aim of our analysis was to report the outcome and safety of patients treated with bevacizumab and paclitaxel as first-line treatment for HER2-negative metastatic breast cancer. Between February 2009 and August 2011, 62 consecutive patients received paclitaxel 90 mg/m(2) on days 1, 8, and 15 and bevacizumab (BV) 10 mg/kg intravenously ...
Bresin Konrad - - 2013
Self-control perspectives of multiple traits have been proposed, perhaps most particularly so in the anger realm. Four studies sought to examine potential relations between anger control, trait anger, and motor control. Across the four studies, individuals (total N=366) were asked to hold a joystick cursor on a spatial target as ...
Deng Xiaomei - - 2013
BACKGROUND: Although metastasis-associated protein 1 (MTA1) has been recently demonstrated as a potent angiogenesis-promoting factor in various malignant tumors, its angiogenic property in gastric cancer (GC) remains unclear. This study has detected the expression of MTA1 protein in surgically resected tissues of pathologic N0 (pN0) GC and further investigated its ...
Katayama Ayumi - - 2013
To clarify characteristics of carbon (C) allocation in a Bornean tropical rainforest without dry seasons, gross primary production (GPP) and C allocation, i.e., above-ground net primary production (ANPP), aboveground plant respiration (APR), and total below-ground carbon flux (TBCF) for the forest were examined and compared with those from Amazonian tropical ...
Liu Jie - - 2013
By introducing phenyl groups into the 2- and 6-positions of 11,11,12,12-tetracyano-9,10-anthraquinodimethane, a material (dP-TCAQ) with aggregation-induced emission enhancement (AEE) characteristics was synthesized. The AEE phenomenon was explained by analysis of its solid-state packing mode. To our best knowledge, this is the first report regarding 11,11,12,12-tetracyano-9,10-anthraquinodimethane with AEE behaviour.
Cordero Mario D - - 2013
In order to analyze the association between body mass index (BMI), lipid profile and clinical symptoms in patients with fibromyalgia, we assessed BMI levels, lipid profile and its association with clinical symptoms in 183 patients with fibromyalgia. The patients were evaluated using tender points, FIQ and Visual Analogue Scales of ...
Sattler Susanne - - 2013
Interleukin (IL)-33 is a recently identified pleiotropic cytokine, which can orchestrate complex innate and adaptive immune responses in immunity and disease. It has been characterized as a cytokine of the IL-1 family and affects a wide range of immune cells by signalling through its receptor ST2L. Accumulating evidence suggests a ...
Cao Yuanyuan - - 2013
Multi-helical DNA-silica fibers were synthesised by the self-assembly of DNA molecules with cationic organosilanes and silica sources. By electron microscopy images and circular dichroism spectra, three-level helical structures in the silica fibers have been revealed, i.e. the DNA double-helix, the secondary left-handed DNA packing and the tertiary right-handed twisting.
Havasi Parvaneh - - 2013
Feeder layers have been applied extensively to support the growth and stemness potential of stem cells for in vitro cultures. Mouse embryonic fibroblast and mouse fibroblast cell line (SNL) are common feeder cells for human induced pluripotent stem cells (hiPSCs) culture. Because of some problems in the use of these ...
Jazi Mehdi Salimi - - 2013
The results of a computational study of a helmeted human head are presented in this paper. The focus of the work is to study the effects of helmet pad materials on the level of acceleration, inflicted pressure and shear stress in a human brain model subjected to a ballistic impact. ...
Takeda Kazuhisa - - 2013
Background/Aims: To clarify the surgical outcome and propose an appropriate strategy for biliary stricture (BS) treatment after living donor liver transplantation (LDLT). Methodology: Among 53 patients who underwent LDLT at our institute, 45 patients had duct-to-duct anastomosis. Of these, 33 who survived for at least 12 months after LDLT comprised ...
Qiu Linghua - - 2013
ABSTRACT: BACKGROUND: A proline-to-serine substitution at position-56 (P56S) of vesicle-associated membrane protein-associated protein B (VAPB) causes a form of dominantly inherited motor neuron disease (MND), including typical and atypical amyotrophic lateral sclerosis (ALS) and a mild late-onset spinal muscular atrophy (SMA). VAPB is an integral endoplasmic reticulum (ER) protein and ...
Mesmin Bruno - - 2013
In cells, the levels of sterol vary greatly among organelles. This uneven distribution depends largely on non-vesicular routes of transfer, which are mediated by soluble carriers called lipid-transfer proteins (LTPs). These proteins have a domain with a hydrophobic cavity that accommodates one sterol molecule. However, a demonstration of their role ...
Digangi Julia - - 2013
ABSTRACT: BACKGROUND: Posttraumatic stress disorder (PTSD) is a debilitating anxiety disorder. Surveys of the general population suggest that while 50-85% of Americans will experience a traumatic event in their lifetime, only 2-50% will develop PTSD. Why some individuals develop PTSD following trauma exposure while others remain resilient is a central ...
Mason Claire E - - 2013
Single-stranded DNA-binding proteins (SSBs) are ubiquitous oligomeric proteins that bind with very high affinity to single-stranded DNA and have a variety of essential roles in DNA metabolism. Nanoelectrospray ionization mass spectrometry (nanoESI-MS) was used to monitor subunit exchange in full-length and truncated forms of the homotetrameric SSB from Escherichia coli. ...
Rosendal Marianne - - 2013
Objective. To estimate the frequency of psychological and social classification codes employed by general practitioners (GPs) and to explore the extent to which GPs ascribed health problems to biomedical, psychological, or social factors. Design. A cross-sectional survey based on questionnaire data from GPs. Setting. Danish primary care. Subjects. 387 GPs ...
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