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Thomasy Sara M - - 2013
A 16-year-old spayed female cat was evaluated for lagophthalmos and chronic exposure keratitis in both eyes. Ophthalmic examination revealed upper and lower eyelid entropion of the left eye (OS) and markedly decreased retropulsion, restricted eye movement, marked episcleral congestion, and severe keratitis of both eyes (OU). Magnetic resonance imaging of ...
- - 2013
To the Editor: In their historical overview of global efforts to control tuberculosis, Keshavjee and Farmer (Sept. 6 issue)(1) argue that the prioritization of global health funding based on measurable outcomes and high-return investments contributed to the fragmentation of primary health care. We agree but acknowledge that it can be ...
Hoshino Yuichi - - 2013
BACKGROUND: Rotational kinematics has become an important consideration after ACL reconstruction because of its possible influence on knee degeneration. However, it remains unknown whether ACL reconstruction can restore both rotational kinematics and normal joint contact patterns, especially during functional activities. QUESTIONS/PURPOSES: We asked whether knee kinematics (tibial anterior translation and ...
Oguri Kazuo - - 2013
AIM: To investigate the association between Trp64Arg polymorphism of the beta3-adrenergic receptor (ADRB3) gene and total fat mass, abdominal fat distribution, other metabolic derangements and metabolic syndrome (MS) in Japanese children. METHODS: Molecular screening of the ADRB3 gene polymorphism (Trp64Trp, Trp64Arg, and Arg64Arg) was carried out in 132 children aged ...
van Hattum Hilde - - 2013
Inhibitors for galectin-1 and -3 were synthesized from thiodigalactoside and lactosamine by derivatization of the galactose C3. Introduction of 4-phenyl-1H-1,2,3-triazol-1-yl substituents at the thiodigalactoside C3 by CuAAC, targeting arginine-arene interactions, increased the affinity to 13 nM, but yielded little selectivity. The bulkier 4-(4-phenoxyphenyl)-1H-1,2,3-triazol-1-yl substituent, however, increased the preference for galectin-3 ...
Gao Sheng - - 2013
Background/Aims: Doxorubicin-eluting bead TACE (DEB-TACE) has recently been developed as a novel therapy option for HCC. However, the clinical efficacy of DEB-TACE is still unclear. Herein, we performed a meta-analysis to evaluate the efficacy of DEB-TACE compared with conventional TACE (cTACE). Methodology: We inlcuded seven studies (a total of 693 ...
Asberg Arne - - 2013
Abstract Objective. In addition to hepatocellular cancer, HFE C282Y homozygotes are reported to have increased risk of colorectal cancer and breast cancer. This study was done to further explore the cancer risk in C282Y homozygotes. Material and methods. We studied cancer incidence in 292 homozygotes and 62,568 others that participated ...
Cheng Qingsu - - 2013
Despite their indisputable clinical value, current tissue engineering strategies face major challenges in recapitulating the natural nano-structural and morphological features of native bone. The aim of this study is to take a step forward by developing a porous scaffold with appropriate mechanical strength and controllable surface roughness for bone repair. ...
Bolland Mark J - - 2013
To the Editor: Thigpen et al. (Aug. 2 issue)(1) report that persons who are seronegative for the human immunodeficiency virus (HIV) and who are receiving tenofovir disoproxil fumarate and emtricitabine (TDF-FTC) for preexposure prophylaxis had decreased bone mineral density at 24 months, as compared with those receiving placebo. In HIV-infected ...
Terzi Fabio - - 2013
A gold electrode partially coated by graphene multilayer is developed and tested with respect to high concentrations of hydrogen peroxide. The effective use of conventional electrode materials for the determination of such an analyte by anodic oxidation or cathodic reduction is prevented by the occurrence of adsorptions fouling the electrode ...
Mullaji Arun B - - 2013
BACKGROUND: Extensive posteromedial release to correct severe varus deformity during TKA may result in mediolateral or flexion instability and may require a constrained implant. We describe a technique combining computer navigation and medial condylar osteotomy in severe varus deformity to achieve a primary goal of ligament balance during TKA. DESCRIPTION ...
Hurol Yonca - - 2013
The most common tectonic quality of modern structures, such as frame systems, is their flexibility; they are open for change. Although this characteristic is a big advantage in comparison to the inflexible masonry structures of the past, it might also create some serious problems, such as e.g. the lack of ...
Osako Tomo - - 2013
By definition, ductal carcinoma in situ (DCIS)-preinvasive breast cancer-does not metastasise to the lymph nodes. However, since the introduction of molecular whole-node analysis using the one-step nucleic acid amplification (OSNA) assay for sentinel node (SN) biopsies, the number of patients with DCIS and SN metastasis has increased. The pathogenesis and ...
Zheng Feng - - 2013
Abnormal hypermethylation of CpG islands not only associated with tumor suppressor genes can lead to repression of gene expression, but also contribute to escape of the tumor from immune surveillance and contribute significantly to tumorigenesis. In the present study, we studied the hypermethylation of low molecular-weight protein (LMP) gene and ...
Bigoni Lucie - - 2013
The socioeconomic structure of an early medieval society from the MikulĨice settlement (Czech Republic) was studied on the basis of an evaluation of the fluctuating and directional asymmetry (DA) of skulls. Two distinct inhabited regions, castle and sub-castle, were compared. Fluctuating asymmetry (FA) was used as a bioindicator of environmental ...
Chen Tzu-Tso - - 2013
A V(III) thiolate complex activated C-Cl bond in dichloromethane via S-based nucleophilic attack. The reaction products, a V(III)-Cl species (major one) and a V(IV) binding to a CH(2) containing ligand (minor one) were obtained. The work demonstrates sulfur donors in the early-transition metal thiolates having strong nucleophilic characteristics.
Ripa Rasmus S - - 2013
Background. Granulocyte-colony-stimulating factor (G-CSF) has been investigated in trials aiming to promote recovery of myocardial function after myocardial infarction. Long-term safety-data have never been reported. A few studies indicated an increased risk of in-stent re-stenosis. We aimed to investigate clinical events 5 years after inclusion into a randomized trial of ...
Kano Taichi - - 2013
A one-pot cross double-Mannich reaction of acetaldehyde was developed, and densely functionalized 1,3-diamines were obtained as a single stereoisomer by use of axially chiral amino sulfonamide (S)- as catalyst. Using this catalyst, the one-pot Mannich reaction-aminoxylation was also realized.
Al Mutairi Muna - - 2013
Hyperimmunoglobulin E syndrome (HIES) is a primary immunodeficiency disorder with multisystem abnormalities including the vascular system. We report a child with autosomal recessive (AR)-HIES secondary to dedicator of cytokinesis 8 (DOCK8) deficiency who developed critical aortic aneurysm involving the ascending aorta and aortic arch with narrowing of descending aorta that was successfully ...
Nie Yan - - 2013
Identification of new nasopharyngeal carcinoma (NPC) biomarkers is of great clinical value for the diagnosis and treatment of NPC. HOTAIR, a cancer-related long noncoding RNA, was tested and its prognostic value for NPC was evaluated. Determined by In situ hybridization (ISH), 91 of 160 (56.87%) paraffin-embedded NPC biopsies showed high ...
Shindoh Junichi - - 2013
Background/Aim: Anatomic resection of the liver is one of the essential techniques in liver surgery. However, parenchymal transection precisely along intersegmental planes is still a technically demanding procedure, and an optimal navigation method is required. Methodology: Real-time ultrasound monitoring with a probe applied from behind the liver was tried as ...
Jeon Eun-Ju - - 2013
PURPOSE: In this study, we evaluated the surgical and radiologic anatomy of a cochleostomy produced via posterior tympanotomy for cochlear implantation (CI). MATERIALS AND METHODS: Twenty computed tomography (CT) images of the temporal bone from patients aged between 20 and 60 years were selected. The inclusion criterion was a radiologically normal ...
Burt Ronald S - - 2013
We provide an overview of social network analysis focusing on network advantage as a lens that touches on much of the area. For reasons of good data and abundant research, we draw heavily on studies of people in organizations. Advantage is traced to network structure as a proxy for the ...
- - 2013
Repackaging Cigarettes - Will the Courts Thwart the FDA? Perspective, N Engl J Med 2012;367:2065-2067. In the first sentence of the article (page 2065), "August 12, 2012" should have been "August 15, 2012," and "mouth ulcers" should have been "mouth cancer." Also, in the reference list (page 2067), reference 5 ...
Mershiba Sam Daniel - - 2013
Arsenic has a long history as a potent human poison, chronic exposure over a period of time may result in the manifestation of toxicity in practically all systems of the body. In the present investigation the efficacy of naringenin (NRG), a naturally occurring citrus flavanone against arsenic-induced hepatotoxic and nephrotoxic ...
Hamzeh-Mivehroud Maryam - - 2013
Abstract 1. Flavonoids are a group of polyphenolic plant metabolites most commonly known for their antioxidant activities. They also show inhibitory activities on molybdo-flavoenzymes family of enzymes which are involved in biotransformation of some exogenous and endogenous chemicals. Most notably, aldehyde oxidase (AO), a member of this family, is responsible ...
Nair Bala G - - 2013
Blood pressure monitoring during anesthesia is an American Society of Anesthesiology standard. However, the anesthesia provider sometimes fails to engage the patient monitor to make periodic (generally every 3-5 min) measurements of Non-Invasive Blood Pressure (NIBP), which can lead to extended periods (>5 min) when blood pressure is not monitored. We describe ...
Johnston Stephen R D - - 2013
This phase II study (VEG20007; NCT00347919) with randomized and open-label components evaluated first-line lapatinib plus pazopanib therapy and/or lapatinib monotherapy in patients with human epidermal growth factor receptor type 2 (HER2)-positive advanced/metastatic breast cancer. Patients were enrolled sequentially into two cohorts: Cohort 1, patients were randomly assigned to lapatinib 1,000 mg ...
Xu Jiuping - - 2013
To examine depression severity and associated risk factors 1 year later among survivors of the May 12, 2008 Wenchuan earthquake in China, a cross-sectional study was conducted. Subjects included 704 survivors, ages 18-64, 367 (52.1 %) of whom were from heavily damaged counties and the rest from moderately damaged ones. Subjects were ...
Hernández Redondo Ana - - 2013
BACKGROUND: Ethyl glucuronide (EtG) and ethyl sulfate (EtS) are non-oxidative minor metabolites of ethanol. They are detectable in various body fluids shortly after initial consumption of ethanol and have a longer detection time frame than the parent compound. They are regarded highly sensitive and specific markers of recent alcohol uptake. ...
Ishibashi H - - 2013
PURPOSE: To evaluate the late events and mid-term results after endovascular aneurysm repair (EVAR). METHODS: Between December 2006 and May 2012, 175 abdominal aortic aneurysms were treated by EVAR. Aneurysm-related events were analyzed. RESULTS: The complications that occurred during the EVAR procedure were renal artery occlusion in two patients, access ...
Kenyon Chris - - 2013
To the Editor: Thigpen et al. (Aug. 2 issue)(1) report that persons who are seronegative for the human immunodeficiency virus (HIV) and who are receiving tenofovir disoproxil fumarate and emtricitabine (TDF-FTC) for preexposure prophylaxis had decreased bone mineral density at 24 months, as compared with those receiving placebo. In HIV-infected ...
Funakoshi Tomohiro - - 2013
Background. The multitargeted tyrosine kinase inhibitor sunitinib is used in various cancers. Clinical studies have reported a substantial variation in the incidence of hypothyroidism associated with sunitinib, without a systemic attempt to synthesize these data. Methods. We searched Medline databases for relevant clinical trials published up to May 2012. Phase ...
Santiago Alicia - - 2013
The synthesis and mechanistic study of the unprecedented reactivity of a series of zwitterionic η(1)-metal allenyls are reported.
Masters Sarah L - - 2013
The molecular structure of a fundamental binary compound [antimony(iii) oxide] has been re-determined to a far higher accuracy and precision than previously reported. The structure is compared to those determined by various ab initio methods, X-ray diffraction and to a previous gas-phase structure determined by electron diffraction prior to modern-day ...
Güth Uwe - - 2013
INTRODUCTION: Pyoderma gangrenosum (PG) is a rare ulcerative skin disease characterized by a wide variety in its clinical presentation and outcome. The etiology is unknown and the pathogenesis is poorly understood, but autoimmune mechanisms have been suggested. Gynecological reports about PG are particularly scarce. As gynecologists rarely encounter this disorder, ...
Chue P - - 2013
Abstract Objective: To evaluate the long-term clinical benefit and effectiveness of switching to once-daily quetiapine extended release (XR) from an oral antipsychotic in patients with schizophrenia. Reasons for switching included insufficient efficacy, tolerability, and/or non-acceptability. The primary endpoint was the percentage of patients achieving an improvement in Clinical Global Impression ...
Kahilogullari Gokmen - - 2013
PURPOSE: Pineal cysts (PC) are found in children as often asymptomatic and without change in their size over the time. However, there are some debatable issues about their evolution and management in the pediatric population. The aim of the present paper is to update the information regarding pathogenesis, clinical presentation, ...
Jia Baolei - - 2013
Enzymes from many archaea colonizing extreme environments are of great interest because of their potential for various biotechnological processes and scientific value of evolution. Many enzymes from archaea have been reported to catalyze promiscuous reactions or moonlight in different functions. Here, we summarize known archaeal enzymes of both groups that ...
Peserico Alessia - - 2013
Reduction of nutrient intake without malnutrition positively influences lifespan and healthspan from yeast to mice and exerts some beneficial effects also in humans. The AMPK-FoxO axis is one of the evolutionarily conserved nutrient-sensing pathways, and the FOXO3A locus is associated with human longevity. Interestingly, FoxO3A has been reported to be ...
Vahabzadeh Arshya - - 2013
To the Editor: Redelmeier et al. (Sept. 27 issue)(1) report the association between physicians' warnings to unfit drivers and a significant increase in patients' depression, as measured by the rate of emergency department visits for depression. Driving cessation has been correlated with increased depressive symptoms(2) and social isolation(3) and a ...
Kim C H - - 2013
PURPOSE: Pulmonary tuberculosis (PTB), with a tuberculosis (TB)-polymerase chain reaction (PCR)-negative bronchial aspirate (BA), but a positive culture result is often encountered in clinical practice. However, limited data are available concerning clinical judgment in patients with suspected PTB and a TB-PCR-negative BA pending culture results. The present study aimed to ...
Kappes Andreas - - 2013
Implicit theories of emotion-assumptions about whether emotions are fixed (entity theory) or malleable (incremental theory)-have previously been shown to influence affective outcomes over time. We examined whether implicit theories of emotion also relate to the immediate regulation of negative affect. Consistent with our hypotheses, we found that the more students ...
Christopher John A - - 2013
Application WO2012081692 from Taisho Pharmaceutical Co. Ltd. claims pyrazole-based antagonists of the orexin-1 and orexin-2 receptors. Utility in a number of therapeutic areas is claimed, including the treatment of sleep disorders; the most likely use of the claimed compounds. Data from in vitro functional assays are presented, with the claimed ...
Sundin Tabetha - - 2013
We previously demonstrated in prostate cancer cells that a phytochemical-perillyl alcohol-and the mechanistic target of rapamycin (mTOR) inhibitor rapamycin rapidly attenuated telomerase activity. Protein levels of the telomerase catalytic subunit reverse transcriptase (hTERT) were diminished in the absence of an effect on hTERT mRNA, supporting an effect on 4E-BP1 phosphorylation ...
Follin C - - 2013
Acute lymphoblastic leukaemia (ALL) is the most common childhood malignancy. The survival rate in the Scandinavian countries is now around 85 %. ALL patients treated with cranial radiotherapy (CRT) are at risk for growth hormone deficiency (GHD), but little is known about other pituitary insufficiencies, e.g. ACTH. Adult ALL patients (median ...
Graham Jennifer - - 2013
"Curricula-in-action" generally differ from "official" curricula. That is particularly true of clerkship curricula because the practising doctors who supervise medical students' clinical activities are only secondarily educators. Clerkship education is evaluated, however, according to benchmarks set by official curricula. As a result, clerkship evaluations are important points of contact between ...
A Reine Pål - - 2013
Background. The pharmacokinetics of the immunosuppressant mycophenolic acid (MPA) demonstrates high inter- and intra-patient variability. Variation in the binding of MPA to albumin has been postulated to be an important factor in this variability, and monitoring of free MPA has been suggested to improve therapeutic drug monitoring (TDM) of MPA. ...
Li Hongbo - - 2013
An indirect photoelectrochemical sensing platform for toxic hexavalent chromium was for the first time constructed based on its redox reaction with quercetin as both the electron donor and photosensitizer on a TiO(2) photoanode, and thus inhibiting the photocurrent quantitatively and selectively. The presence of even 500-fold coexisting Cr(iii) does not ...
Jessen Jan Peter - - 2013
PURPOSE: Aim of our study was to evaluate the results of percutaneous nephrolithotomy (PNL) with sonographic/fluoroscopic guided puncture during a learning curve and to compare them to an expert. METHODS: The first 75 consecutive patients undergoing conventional PNL or Mini-PNL by a novice percutaneous surgeon without direct supervision by an ...
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