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de Arruda Leme Raquel - - 2013
The aims of this study were to evaluate torque teno sus virus (TTSuV) infection in healthy slaughter-age pigs and to compare the similarities of the untranslated region (UTR) nucleotide (nt) sequences obtained from different biological samples of the same animals. Fifty-eight pigs were evaluated by PCR assay for the presence ...
Calvente A - - 2013
The cohesin complex plays a key role for the maintenance of sister chromatid cohesion and faithful chromosome segregation in both mitosis and meiosis. This complex is formed by two structural maintenance of chromosomes protein family (SMC) subunits and two non-SMC subunits: an α-kleisin subunit SCC1/RAD21/REC8 and an SCC3-like protein. Several ...
- - 2013
Screening women for cervical cancer can save lives. However, among young women, cervical cancer is relatively rare, and too-frequent screening can lead to high costs and adverse events associated with overtreatment. Before 2012, cervical cancer screening guidelines of the American College of Obstetricians and Gynecologists (ACOG), American Cancer Society (ACS), ...
- - 2013
According to the National Highway Traffic Safety Administration (NHTSA), 2.5% of fatal motor vehicle crashes (approximately 730 in 2009) and 2.0% of all crashes with nonfatal injuries (approximately 30,000 in 2009) involve drowsy driving. However, although data collection methods make it challenging to estimate the number of crashes that involve ...
Adamus-Bialek Wioletta - - 2013
Escherichia coli and Proteus mirabilis are important urinary tract pathogens. The constant increase in the antibiotic resistance of clinical bacterial strains has become an important clinical problem. The aim of this study was to compare the antibiotic resistance of 141 clinical (Sweden and Poland) and 42 laboratory (Czech Republic) P. ...
- - 2013
Since 2003, major U.S. organizations consistently have recommended against screening most women for cervical cancer after a total hysterectomy for benign disease. Starting in 2003 and becoming consistent across organizations in 2012, guidelines also state that women with a history of adequate screening no longer should be screened after age ...
Ammirati Enrico - - 2013
To the Editor: Kaptoge and colleagues (Oct. 4 issue)(1) suggest that C-reactive protein (CRP) and fibrinogen, two biomarkers of inflammation, have a significant though limited incremental prognostic value when added to conventional risk factors. However, the implied ordering of risk factors on the basis of the chronology of their identification ...
Dobler Ina M - - 2013
Results from numerous previous studies suggest that when subjects study items from different categories and then repeatedly retrieve, or restudy, some of the items from some of the categories, repeated retrieval, but not repeated study, induces forgetting of related unpracticed items. We investigated in two experiments whether such effects of ...
Schiess Regula - - 2013
The Nariokotome boy skeleton KNM-WT 15000 is the most complete Homo erectus fossil and therefore is key for understanding human evolution. Nevertheless, since Latimer and Ohman (2001) reported on severe congenital pathology in KNM-WT 15000, it is questionable whether this skeleton can still be used as reference for Homo erectus ...
Li Chen - - 2013
The morphological evolution of PANI helixes was achieved without the use of chiral dopants, but by a facile process through the generation of onion-like multi-lamellar vesicles used as a novel soft-template and a liquid crystal acting as a promoter for PANI polymerization and self-assembly, which is a breakthrough for the ...
Yu Shiji - - 2013
A Ni/silicon microchannel plate (Ni/Si MCP) electrode modified with poly(3,4-ethylenedioxythiophene) (PEDOT) was successfully fabricated. The analytical performance of prepared electrode for the simultaneous determination of ascorbic acid (AA), dopamine (DA) and uric acid (UA) was investigated by using cyclic voltammetry and differential pulse voltammetry (DPV). The sensitivities for AA, DA ...
Zou Shihui - - 2013
It is a challenge to use acetonitrile as a cyanating agent because of the difficulty in cleaving its C-CN bond. Herein, we report a mild photo-assisted route to conduct the cyanation of transition metal nitrates using acetonitrile as the cyanating agent coupled with room-temperature C-C bond cleavage. DFT calculations and ...
Zhang Fang-Jie - - 2013
OBJECTIVES: To investigate CD44 levels in articular cartilage of knee osteoarthritis (OA) and the relationship between CD44 and severity of the disease. METHODS: All 50 cartilage tissues included normal and OA cartilage, and were ascribed to the following four groups on the basis of modified Mankin score: normal, mild lesions, ...
- - 2013
To the Editor: In their historical overview of global efforts to control tuberculosis, Keshavjee and Farmer (Sept. 6 issue)(1) argue that the prioritization of global health funding based on measurable outcomes and high-return investments contributed to the fragmentation of primary health care. We agree but acknowledge that it can be ...
Oguri Kazuo - - 2013
AIM: To investigate the association between Trp64Arg polymorphism of the beta3-adrenergic receptor (ADRB3) gene and total fat mass, abdominal fat distribution, other metabolic derangements and metabolic syndrome (MS) in Japanese children. METHODS: Molecular screening of the ADRB3 gene polymorphism (Trp64Trp, Trp64Arg, and Arg64Arg) was carried out in 132 children aged ...
van Hattum Hilde - - 2013
Inhibitors for galectin-1 and -3 were synthesized from thiodigalactoside and lactosamine by derivatization of the galactose C3. Introduction of 4-phenyl-1H-1,2,3-triazol-1-yl substituents at the thiodigalactoside C3 by CuAAC, targeting arginine-arene interactions, increased the affinity to 13 nM, but yielded little selectivity. The bulkier 4-(4-phenoxyphenyl)-1H-1,2,3-triazol-1-yl substituent, however, increased the preference for galectin-3 ...
Gao Sheng - - 2013
Background/Aims: Doxorubicin-eluting bead TACE (DEB-TACE) has recently been developed as a novel therapy option for HCC. However, the clinical efficacy of DEB-TACE is still unclear. Herein, we performed a meta-analysis to evaluate the efficacy of DEB-TACE compared with conventional TACE (cTACE). Methodology: We inlcuded seven studies (a total of 693 ...
Asberg Arne - - 2013
Abstract Objective. In addition to hepatocellular cancer, HFE C282Y homozygotes are reported to have increased risk of colorectal cancer and breast cancer. This study was done to further explore the cancer risk in C282Y homozygotes. Material and methods. We studied cancer incidence in 292 homozygotes and 62,568 others that participated ...
Cheng Qingsu - - 2013
Despite their indisputable clinical value, current tissue engineering strategies face major challenges in recapitulating the natural nano-structural and morphological features of native bone. The aim of this study is to take a step forward by developing a porous scaffold with appropriate mechanical strength and controllable surface roughness for bone repair. ...
Bolland Mark J - - 2013
To the Editor: Thigpen et al. (Aug. 2 issue)(1) report that persons who are seronegative for the human immunodeficiency virus (HIV) and who are receiving tenofovir disoproxil fumarate and emtricitabine (TDF-FTC) for preexposure prophylaxis had decreased bone mineral density at 24 months, as compared with those receiving placebo. In HIV-infected ...
Terzi Fabio - - 2013
A gold electrode partially coated by graphene multilayer is developed and tested with respect to high concentrations of hydrogen peroxide. The effective use of conventional electrode materials for the determination of such an analyte by anodic oxidation or cathodic reduction is prevented by the occurrence of adsorptions fouling the electrode ...
Hurol Yonca - - 2013
The most common tectonic quality of modern structures, such as frame systems, is their flexibility; they are open for change. Although this characteristic is a big advantage in comparison to the inflexible masonry structures of the past, it might also create some serious problems, such as e.g. the lack of ...
Osako Tomo - - 2013
By definition, ductal carcinoma in situ (DCIS)-preinvasive breast cancer-does not metastasise to the lymph nodes. However, since the introduction of molecular whole-node analysis using the one-step nucleic acid amplification (OSNA) assay for sentinel node (SN) biopsies, the number of patients with DCIS and SN metastasis has increased. The pathogenesis and ...
Zheng Feng - - 2013
Abnormal hypermethylation of CpG islands not only associated with tumor suppressor genes can lead to repression of gene expression, but also contribute to escape of the tumor from immune surveillance and contribute significantly to tumorigenesis. In the present study, we studied the hypermethylation of low molecular-weight protein (LMP) gene and ...
Bigoni Lucie - - 2013
The socioeconomic structure of an early medieval society from the MikulĨice settlement (Czech Republic) was studied on the basis of an evaluation of the fluctuating and directional asymmetry (DA) of skulls. Two distinct inhabited regions, castle and sub-castle, were compared. Fluctuating asymmetry (FA) was used as a bioindicator of environmental ...
Chen Tzu-Tso - - 2013
A V(III) thiolate complex activated C-Cl bond in dichloromethane via S-based nucleophilic attack. The reaction products, a V(III)-Cl species (major one) and a V(IV) binding to a CH(2) containing ligand (minor one) were obtained. The work demonstrates sulfur donors in the early-transition metal thiolates having strong nucleophilic characteristics.
Ripa Rasmus S - - 2013
Background. Granulocyte-colony-stimulating factor (G-CSF) has been investigated in trials aiming to promote recovery of myocardial function after myocardial infarction. Long-term safety-data have never been reported. A few studies indicated an increased risk of in-stent re-stenosis. We aimed to investigate clinical events 5 years after inclusion into a randomized trial of ...
Kano Taichi - - 2013
A one-pot cross double-Mannich reaction of acetaldehyde was developed, and densely functionalized 1,3-diamines were obtained as a single stereoisomer by use of axially chiral amino sulfonamide (S)- as catalyst. Using this catalyst, the one-pot Mannich reaction-aminoxylation was also realized.
Al Mutairi Muna - - 2013
Hyperimmunoglobulin E syndrome (HIES) is a primary immunodeficiency disorder with multisystem abnormalities including the vascular system. We report a child with autosomal recessive (AR)-HIES secondary to dedicator of cytokinesis 8 (DOCK8) deficiency who developed critical aortic aneurysm involving the ascending aorta and aortic arch with narrowing of descending aorta that was successfully ...
Nie Yan - - 2013
Identification of new nasopharyngeal carcinoma (NPC) biomarkers is of great clinical value for the diagnosis and treatment of NPC. HOTAIR, a cancer-related long noncoding RNA, was tested and its prognostic value for NPC was evaluated. Determined by In situ hybridization (ISH), 91 of 160 (56.87%) paraffin-embedded NPC biopsies showed high ...
Shindoh Junichi - - 2013
Background/Aim: Anatomic resection of the liver is one of the essential techniques in liver surgery. However, parenchymal transection precisely along intersegmental planes is still a technically demanding procedure, and an optimal navigation method is required. Methodology: Real-time ultrasound monitoring with a probe applied from behind the liver was tried as ...
Jeon Eun-Ju - - 2013
PURPOSE: In this study, we evaluated the surgical and radiologic anatomy of a cochleostomy produced via posterior tympanotomy for cochlear implantation (CI). MATERIALS AND METHODS: Twenty computed tomography (CT) images of the temporal bone from patients aged between 20 and 60 years were selected. The inclusion criterion was a radiologically normal ...
Burt Ronald S - - 2013
We provide an overview of social network analysis focusing on network advantage as a lens that touches on much of the area. For reasons of good data and abundant research, we draw heavily on studies of people in organizations. Advantage is traced to network structure as a proxy for the ...
- - 2013
Repackaging Cigarettes - Will the Courts Thwart the FDA? Perspective, N Engl J Med 2012;367:2065-2067. In the first sentence of the article (page 2065), "August 12, 2012" should have been "August 15, 2012," and "mouth ulcers" should have been "mouth cancer." Also, in the reference list (page 2067), reference 5 ...
Mershiba Sam Daniel - - 2013
Arsenic has a long history as a potent human poison, chronic exposure over a period of time may result in the manifestation of toxicity in practically all systems of the body. In the present investigation the efficacy of naringenin (NRG), a naturally occurring citrus flavanone against arsenic-induced hepatotoxic and nephrotoxic ...
Hamzeh-Mivehroud Maryam - - 2013
Abstract 1. Flavonoids are a group of polyphenolic plant metabolites most commonly known for their antioxidant activities. They also show inhibitory activities on molybdo-flavoenzymes family of enzymes which are involved in biotransformation of some exogenous and endogenous chemicals. Most notably, aldehyde oxidase (AO), a member of this family, is responsible ...
Nair Bala G - - 2013
Blood pressure monitoring during anesthesia is an American Society of Anesthesiology standard. However, the anesthesia provider sometimes fails to engage the patient monitor to make periodic (generally every 3-5 min) measurements of Non-Invasive Blood Pressure (NIBP), which can lead to extended periods (>5 min) when blood pressure is not monitored. We describe ...
Johnston Stephen R D - - 2013
This phase II study (VEG20007; NCT00347919) with randomized and open-label components evaluated first-line lapatinib plus pazopanib therapy and/or lapatinib monotherapy in patients with human epidermal growth factor receptor type 2 (HER2)-positive advanced/metastatic breast cancer. Patients were enrolled sequentially into two cohorts: Cohort 1, patients were randomly assigned to lapatinib 1,000 mg ...
Xu Jiuping - - 2013
To examine depression severity and associated risk factors 1 year later among survivors of the May 12, 2008 Wenchuan earthquake in China, a cross-sectional study was conducted. Subjects included 704 survivors, ages 18-64, 367 (52.1 %) of whom were from heavily damaged counties and the rest from moderately damaged ones. Subjects were ...
Hernández Redondo Ana - - 2013
BACKGROUND: Ethyl glucuronide (EtG) and ethyl sulfate (EtS) are non-oxidative minor metabolites of ethanol. They are detectable in various body fluids shortly after initial consumption of ethanol and have a longer detection time frame than the parent compound. They are regarded highly sensitive and specific markers of recent alcohol uptake. ...
Ishibashi H - - 2013
PURPOSE: To evaluate the late events and mid-term results after endovascular aneurysm repair (EVAR). METHODS: Between December 2006 and May 2012, 175 abdominal aortic aneurysms were treated by EVAR. Aneurysm-related events were analyzed. RESULTS: The complications that occurred during the EVAR procedure were renal artery occlusion in two patients, access ...
Kenyon Chris - - 2013
To the Editor: Thigpen et al. (Aug. 2 issue)(1) report that persons who are seronegative for the human immunodeficiency virus (HIV) and who are receiving tenofovir disoproxil fumarate and emtricitabine (TDF-FTC) for preexposure prophylaxis had decreased bone mineral density at 24 months, as compared with those receiving placebo. In HIV-infected ...
Funakoshi Tomohiro - - 2013
Background. The multitargeted tyrosine kinase inhibitor sunitinib is used in various cancers. Clinical studies have reported a substantial variation in the incidence of hypothyroidism associated with sunitinib, without a systemic attempt to synthesize these data. Methods. We searched Medline databases for relevant clinical trials published up to May 2012. Phase ...
Santiago Alicia - - 2013
The synthesis and mechanistic study of the unprecedented reactivity of a series of zwitterionic η(1)-metal allenyls are reported.
Masters Sarah L - - 2013
The molecular structure of a fundamental binary compound [antimony(iii) oxide] has been re-determined to a far higher accuracy and precision than previously reported. The structure is compared to those determined by various ab initio methods, X-ray diffraction and to a previous gas-phase structure determined by electron diffraction prior to modern-day ...
Güth Uwe - - 2013
INTRODUCTION: Pyoderma gangrenosum (PG) is a rare ulcerative skin disease characterized by a wide variety in its clinical presentation and outcome. The etiology is unknown and the pathogenesis is poorly understood, but autoimmune mechanisms have been suggested. Gynecological reports about PG are particularly scarce. As gynecologists rarely encounter this disorder, ...
Chue P - - 2013
Abstract Objective: To evaluate the long-term clinical benefit and effectiveness of switching to once-daily quetiapine extended release (XR) from an oral antipsychotic in patients with schizophrenia. Reasons for switching included insufficient efficacy, tolerability, and/or non-acceptability. The primary endpoint was the percentage of patients achieving an improvement in Clinical Global Impression ...
Kahilogullari Gokmen - - 2013
PURPOSE: Pineal cysts (PC) are found in children as often asymptomatic and without change in their size over the time. However, there are some debatable issues about their evolution and management in the pediatric population. The aim of the present paper is to update the information regarding pathogenesis, clinical presentation, ...
Jia Baolei - - 2013
Enzymes from many archaea colonizing extreme environments are of great interest because of their potential for various biotechnological processes and scientific value of evolution. Many enzymes from archaea have been reported to catalyze promiscuous reactions or moonlight in different functions. Here, we summarize known archaeal enzymes of both groups that ...
Peserico Alessia - - 2013
Reduction of nutrient intake without malnutrition positively influences lifespan and healthspan from yeast to mice and exerts some beneficial effects also in humans. The AMPK-FoxO axis is one of the evolutionarily conserved nutrient-sensing pathways, and the FOXO3A locus is associated with human longevity. Interestingly, FoxO3A has been reported to be ...
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