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Brooke Christopher B CB Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, - - 2013
Segmentation of the influenza A virus (IAV) genome enables rapid gene reassortment at the cost of complicating the task of assembling the full viral genome. By simultaneously probing for the expression of multiple viral proteins in MDCK cells infected at a low multiplicity with IAV, we observe that the majority ...
Xu Ming M Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, - - 2013
Activation of the death receptor Fas has been reported to produce a two-phase intracellular Ca(2+) release response in coronary arterial myocytes (CAMs), which consists of local Ca(2+) bursts via lysosomal transient potential receptor-mucolipin 1 (TRP-ML1) channels and consequent Ca(2+) release from the sarcoplasmic reticulum (SR). The present study was designed ...
Howard Luke R - - 2013
Chokeberry anthocyanins are susceptible to degradation during processing and storage of processed products. In this study we determined the effects of three pH levels (2.8, 3.2, and 3.6) and four beta cyclodextrin (BCD) concentrations (0, 0.5, 1, and 3%) alone and in combination on the stability of chokeberry juice anthocyanins ...
Gamboa Alfredo A Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, - - 2013
The objective is to study the role of nitric oxide (NO) on cardiovascular regulation in healthy subjects and postural tachycardia syndrome (POTS) patients. Reduced neuronal NO function, which could contribute to a hyperadrenergic state, and increased NO-induced vasodilation, which could contribute to orthostatic intolerance, have been reported in POTS. In ...
Zöttl Markus M Department of Behavioural Ecology, Institute of Ecology and Evolution, University of Bern, Hinterkappelen, Switzerland. - - 2013
In cooperative breeders, sexually mature subordinates can either queue for chances to inherit the breeding position in their natal group, or disperse to reproduce independently. The choice of one or the other option may be flexible, as when individuals respond to attractive dispersal options, or they may reflect fixed life-history ...
Ding Yonghe Y Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, - - 2013
Mutagenesis screening is a powerful genetic tool for probing biological mechanisms underlying vertebrate development and human diseases. However, the increased colony management efforts in vertebrates impose a significant challenge for identifying genes affecting a particular organ, such as the heart, especially those exhibiting adult phenotypes on depletion. We aim to ...
Genovesi Simonetta - - 2013
AIMS: A high prevalence of prolonged QT interval duration has been observed among haemodialysis (HD) patients. The aim of this cases series was to describe the association of various risk factors with total mortality and sudden cardiac death (SCD) in this population.METHODS AND RESULTS: One hundred and twenty-two patients undergoing ...
Young Shih-Houng - - 2013
ABSTRACT An association has been observed between indoor mold contamination and lung allergy and asthma. This relationship is not fully understood. 1→3-β-Glucan is the major cell wall component of fungi and a good marker of fungi exposure. The objective was to evaluate the adjuvant effect of zymosan, a crude yeast ...
Bylund Johan - - 2013
A novel microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor induced kidney injury at exposures representing less than four times the anticipated efficacious exposure in man during a 7-day toxicity study in rats. Findings consisted mainly of tubular lesions and presence of crystalline material and increases in plasma urea and creatinine. ...
Vetter Alexandra - - 2013
Adenovirus type 5 (Ad) is an efficient gene vector with high gene transduction potential, but its efficiency depends on its native cell receptors Coxsackie- and Adenovirus Receptor (CAR) for cell attachment and αvβ3/5 integrins for internalisation. To enable transduction of CAR negative cancer cell lines, we have coated the negatively ...
Stamm Ivonne - - 2013
Yersinia enterocolitica is the main cause of yersiniosis in Europe, one of the five main bacterial gastrointestinal diseases of humans. Beside pigs, companion animals, especially dogs and cats, were repeatedly discussed in the past as a possible source of pathogenic Y. enterocolitica. To investigate the presence and types of Y. ...
Schilling Kevin M - - 2013
We present a new method for fabricating three-dimensional paper-based fluidic devices that uses toner as a thermal adhesive to bond multiple layers of patterned paper together. The fabrication process is rapid, involves minimal equipment (a laser printer and a laminator) and produces complex channel networks with dimensions down to 1 ...
Prindle Marc J MJ Joseph Gottstein Memorial Laboratory, Department of Pathology, University of Washington, Seattle, Washington 98195, - - 2013
DNA polymerase δ (Pol δ) is one of the major replicative DNA polymerases in eukaryotic cells, catalyzing lagging strand synthesis as well as playing a role in many DNA repair pathways. The catalytic site for polymerization consists of a palm domain and mobile fingers domain that opens and closes each ...
Almenrader Nicole - - 2013
OBJECTIVES/AIMS: To investigate whether melatonin would be an alternative drug to clonidine for performance of steal induction. BACKGROUND: Distress during induction might have a negative impact on postoperative behavior. A steal induction is a technique for smooth anesthesia induction, and clonidine has been the primary agent for this purpose. There ...
Mechem C Crawford - - 2013
Abstract Advances in the management of heart failure have led to an increasing number of patients living outside the hospital with a variety of ventricular-assist devices (VADs). These implantable pumps may be placed temporarily as a bridge to cardiac transplantation or resolution of a reversible condition, or as destination therapy ...
Jiang Liyun - - 2013
ABSTRACT: BACKGROUND: Dengue virus (DENV) infection is the most prevalent arthropod-borne viral infection in tropical and subtropical regions worldwide. Guangzhou has the ideal environment for DENV transmission and DENV epidemics have been reported in this region for more than 30 years. FINDINGS: In this study, the epidemiological and virological characteristics ...
Kliegman Sarah - - 2013
The phototransformation of triclosan has been a matter of longstanding interest due to both its prevalence in the environment and the discovery of 2,8 dichlorodibenzodioxin as a photoproduct. In this study, photolysis of triclosan resulted in several primary photoproducts including: 2,8-dichlorodibenzodioxin (4 %), 4,5'-dichloro-[1,1'-biphenyl]-2,2'-diol (10 %), 5-chloro-2-(4-chlorophenoxy)phenol (0.5 %), and ...
Peebles Charles - - 2013
The year of 2012 has seen many significant publications in cardiac imaging, particularly in the modalities of cardiovascular magnetic resonance and cardiac computed tomography. This article will review in brief some of the most important studies with a particular emphasis on the new evidence base for perfusion imaging both by ...
Frank Richard G - - 2013
There are 9.2 million people who are eligible for both Medicare and Medicaid. They're eligible for both programs either because they are younger than 65 years of age, disabled, and poor or because they are 65 or older and are poor or have exhausted their nonhousing assets paying for health ...
Coupaye Muriel - - 2013
Context:Children with Prader-Willi syndrome (PWS) who receive GH treatment have improved growth and body composition; however, data are lacking for adults when treatment is discontinued after completion of growth.Objectives:Our aim was to compare body composition and metabolic status in adults with PWS according to GH treatment in childhood and adolescence.Design:64 ...
Kvirkvelia Nino N Dept. of Medicine, Medical College of Georgia, Georgia Health Sciences Univ., Georgia, GA, - - 2013
We postulated that prostaglandin E2 (PGE2), which exhibits regulatory functions to control immune-mediated inflammation, fibrosis, oxidative stress, and tissue/cellular regeneration, has the potential to improve the course of nephritis. Therefore, the therapeutic potential of prostanoid on established nephritis in mice was evaluated focusing on its role on renal cellular recovery, ...
Lee Won-Mo - - 2013
Purpose: To investigate the effects of rapamycin on the TNF-α-induced secretion of interleukin-6 (IL-6) and IL-8 in orbital fibroblasts and its possible mechanism. Materials and methods: Orbital fibroblasts were obtained from patients with thyroid-associated ophthalmopathy. IL-6 and IL-8 levels were measured by enzyme-linked immunosorbent assays. The down-regulation of PDCD4 was ...
Hütter Sylvia - - 2013
Foamy viruses (FVs) are unique among retroviruses in performing genome reverse transcription (RTr) late in replication, resulting in an infectious DNA genome, and also in their unusual Pol biosynthesis and encapsidation strategy. In addition, FVs display only very limited Gag and Pol processing by the viral protease (PR) during particle ...
Abedelmalek Salma - - 2013
The purpose of this study was to evaluate the effects of partial sleep deprivation (PSD) on circulating concentrations of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in relation to the secretory profiles of growth hormone (GH), cortisol, and testosterone during a repeated brief sprint interval exercise. Thirty healthy football players ...
Rodebaugh Thomas L TL The Anxiety and Psychotherapy Laboratory, Washington University, St. Louis, Missouri, USA. - - 2013
Several studies have demonstrated that D-cycloserine (DCS) facilitates exposure therapy. We developed a standardized test of this facilitation (i.e., a clinical assay), with the goal of testing for facilitation more quickly and inexpensively than a full clinical trial. We developed a standardized brief exposure in which participants with social anxiety ...
Kaufman Yair - - 2013
Supported biomimetic membranes (SBM) on solid substrates have been commonly prepared from vesicle-forming double-tail lipids, such as zwitterionic phospholipids, using the method of vesicle fusion. Here we report on the preparation of SBMs on silica surfaces via a similar process of "micelle fusion" from a cationic single-tail bolaamphiphile GLH-20 that ...
Kashimura Tsutomu - - 2013
We treated a case that exhibited dissociation between blood flow in the transferred jejunum and the monitoring flap. The monitoring flap showed a false-negative, indicating blood flow to be favorable despite blood congestion in the transferred jejunum. The patient was a 69-year-old man. After tumor resection, reconstruction was performed with ...
Karam Matthew D - - 2013
Acquisition of surgical skills through laboratory-based training and simulation is appealing to surgical training programs. The purpose of this study was to provide baseline information on the current use of surgical skills training laboratories in orthopaedic resident education and to determine the interest in expansion of these facilities and training ...
Cenier Tristan - - 2013
The acquisition of sensory information during behavior shapes the neural representation, central processing, and perception of external stimuli. In mammals, a sniff represents the basic unit of odor sampling, yet how sniffing shapes odor representations remains poorly understood. Perhaps the earliest hypothesis of the role of sniffing in olfaction arises ...
Miao Sheng - - 2013
Pyramidal neurons have a highly polarized dendritic morphology, characterized by one long apical dendrite and multiple short basal dendrites. They function as the primary excitatory cells of the mammalian prefrontal cortex and the corticospinal tract. However, the molecular mechanisms underlying the development of polarized dendrite morphology in pyramidal neurons remain ...
Dukhovny Dmitry - - 2013
Objective A previous multisite, randomized, controlled trial of peer support compared with usual care for prevention of postpartum depression demonstrated a reduction in depression symptoms at 12 weeks postbirth. Our objective was to determine the cost-effectiveness of this intervention.Study Design Prospectively planned economic evaluation alongside the clinical trial to determine the cost ...
Zhang Jing-Xian - - 2013
Seven new neolignanamides (1-7), including two pairs of cis- and trans-isomers, and a new lignanamide (8) were isolated from the EtOAc-soluble fraction of an EtOH extract of the root bark of Lycium chinense, together with 22 known phenolic compounds (9-30), four of which were obtained from the genus Lycium for ...
Suárez-Ortiz G Alejandra - - 2013
The (6'S)-configuration of brevipolides A-J (1-10), isolated from Hyptis brevipes, was established by X-ray diffraction analysis of 9 in conjunction with Mosher's ester analysis of the tetrahydro derivative 11 obtained from both geometric isomers 8 and 9 as well as by chemical correlations. The structure of the new brevipolide J ...
Nikkel Lucas E - - 2013
Both type 1 diabetes mellitus and end-stage renal disease are associated with increased fracture risk, likely because of metabolic abnormalities that reduce bone strength. Simultaneous pancreas-kidney transplantation is a treatment of choice for patients with both disorders, yet the effects of simultaneous pancreas-kidney and kidney transplantation alone on post-transplantation fracture ...
Wei Jerry - - 2013
Mammary transcriptome analyses across the lactation cycle, and transgenic animal studies have identified candidate genes for mammogenesis, lactogenesis and involution, however, there is a lack of information on pathways that contribute lactation performance. Previously we have shown significant differences in lactation performance, mammary gland histology and gene expression profiles during ...
Benson Carolyn - - 2013
In the study of Crepeau et al.,(1) there are several findings of interest. These include both novel and confirmatory results: 1) the EEG classification had prognostic value for favorable and unfavorable outcomes; 2) patients with electrographic reactivity were much more likely to recover consciousness than those who did not; 3) ...
An Zhenguo - - 2013
Low density (0.55-0.92g/cm3, depending on the shell thickness and composition) glass-metal-metal triplex-shell hollow particles (TSHP) were prepared by a three-step route. Firstly, micron-sized silicate glass particles with hollow cores, uniform shells and high sphericity were prepared through spray drying and subsequent melting. NiP shell was uniformly assembled to the previously ...
Fendrych Matyás - - 2013
The exocyst complex, an effector of Rho and Rab GTPases, is believed to function as an exocytotic vesicle tether at the plasma membrane before SNARE complex formation. Exocyst subunits localize to secretory active regions of the plasma membrane, exemplified by the outer domain of Arabidopsis root epidermal cells. Using VAEM ...
Gupta Abhinaba - - 2013
Abstract: This article describes the separation of mixtures of fatty acid salts using a new organic solvent nanofiltration membrane based on polydicyclopentadiene (PDCPD). Mixtures of free fatty acids could not be separated by the membranes because they permeated at similar rates. When triisobutylamine was added to the fatty acids, the ...
Bughio Farah F The University of Arizona, Tucson, AZ, - - 2013
Human cytomegalovirus (HCMV) infects a variety of cell types in humans, resulting in a varied pathogenesis in the immunocompromised host. Endothelial cells (ECs) are considered an important target of HCMV infection that may contribute to viral pathogenesis. Although the viral determinants important for entry into ECs are well defined, the ...
Cunha-Bang C da - - 2013
(Val)ganciclovir is used to treat cytomegalovirus (CMV) infection following solid organ (SOT) or hematopoietic stem cell (HSCT) transplantation. Treatment failures occur, but the contribution from 39 known ganciclovir-related mutations (GRMs) in the CMV-UL97 gene remains controversial. We propose a categorization of these GRMs potentially useful when interpreting sequence analyses in ...
Duprez Daniel A DA Cardiovascular Division, University of Minnesota, 420 Delaware St Se, MMC 508, Minneapolis, MN, USA. - - 2013
A parallel physiological pathway for elastic changes is hypothesized for declines in arterial elasticity and lung function. Endothelial dysfunction and inflammation could potentially decrease elasticity of both vasculature and lung tissue. We examined biomarkers, large arterial elasticity and small arterial elasticity (SAE), and forced vital capacity (FVC) in a period ...
Gandevia S C SC Neuroscience Research Australia, Barker Street, Randwick, NSW 2031, Australia. - - 2013
The assessment of voluntary activation of human muscles usually depends on measurement of the size of the twitch produced by an interpolated nerve or cortical stimulus. In many forms of fatiguing exercise the superimposed twitch increases and thus voluntary activation appears to decline. This is termed 'central' fatigue. Recent studies ...
Ngubane Siyabonga - - 2013
A mixed-ligand metal-metal bonded diruthenium complex having the formula Ru(2)(2,4,6-(CH(3))(3)ap)(3)(O(2)CCH(3))Cl where ap is the anilinopyridinate anion was synthesized from the reaction of Ru(2)(O(2)CCH(3))(4)Cl and H(2,4,6-(CH(3))(3)ap), after which the isolated product was structurally, spectroscopically and electrochemically characterized. The crystal structure reveals an unusual arrangement of the bridging ligands around the dimetal ...
Girolami Mauro - - 2013
Common peroneal nerve palsy is an infrequent pathology mostly related to endogenous or exogenous compression. The exogenous compression is frequently related to trauma: knee fractures or hematoma arisen after a direct blow. Fractures may cause a direct lesion of the nerve; hematoma causes a compression of the nerve at the ...
Lauchnor Ellen Grace - - 2013
Strontium-90 is a principal radionuclide contaminant in the subsurface at several Department of Energy sites in the Western US, causing a threat to groundwater quality in areas such as Hanford, WA. In this work, we used laboratory scale porous media flow cells to examine a potential remediation strategy employing co-precipitation ...
Christensen Randilynn - - 2013
The mixed glass former effect (MGFE) is defined as a non-linear and non-additive change in the ionic conductivity with changing glass former composition at constant modifier composition. In this study, sodium borophosphate 0.35 Na2O + 0.65 [xB2O3 + (1-x)P2O5], 0 ≤ x ≤ 1 glasses which have been shown to ...
de Buyl Pierre - - 2013
The fabrication of synthetic self-propelled particles and the experimental investigations of their dynamics have stimulated interest in self-generated phoretic effects that propel nano- and micron-scale objects. Theoretical modeling of these phenomena is often based on a continuum description of the solvent for different phoretic propulsion mechanisms, including, self-electrophoresis, self-diffusiophoresis and ...
Liu Lei - - 2013
Hierarchical FeOOH nanostructure array films constructed by different nanosized building blocks can be synthesized at air-water interface via a bio-inspired gas-liquid diffusion method. In this approach, poly(acrylic acid) (PAA) as a crystal growth modifier plays a crucial role in mediating the morphology and polymorph of FeOOH crystals. With the increase ...
Coëffier Moïse - - 2013
BACKGROUND: Glutamine modulates duodenal protein metabolism in fasted healthy humans, but its effects in a fed state remain unknown. OBJECTIVE: We aimed to assess the effects of either glutamine or an isonitrogenous protein mixture on duodenal protein metabolism in humans in the fed state. DESIGN: Twenty-four healthy volunteers were randomly ...
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