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Guerrini Luca - - 2013
Synthesis of asymmetric nanoparticles, such as gold nanorods, with tunable optical properties providing metal structures with improved SERS performance is playing a critical role in expanding the use of SERS to imaging and sensing applications. However, the synthetic methods usually require surfactants or polymers as shape-directing agents. These chemicals normally ...
Deinbeck Kristin - - 2013
ABSTRACT: Purpose: To evaluate the efficacy of radiotherapy (RT) for early-stage nodal and extranodal marginal zone lymphoma (MZL).Materials and methods: Patients with stage I (n = 22) and stage II (n = 8) MZL, who were treated with RT were reviewed. The primary tumor localisation was in the orbita (n ...
Seeger J B - - 2013
Aseptic loosening is the most common cause for revision unicompartmental knee arthroplasty and is associated with failure of the bone-cement or cement-implant interface. The purpose of the present study was to analyze different bone lavage techniques for the bone-cement and cement-implant interfaces of the femoral component and to study the ...
Ishii Akihiro A Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030, - - 2013
Myelin is a biologically active membrane receiving and processing signals from axons. Although much is known about its structure and molecular composition, the intracellular signal transduction pathways, active during specific phases of myelinogenesis for regulating myelin formation, remain poorly understood. Recent genetic loss-of-function studies have suggested a key role of ...
Bartussek Jan J Institute of Neuroinformatics, University of Zurich and ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. - - 2013
In many animals, rhythmic motor activity is governed by neural limit cycle oscillations under the control of sensory feedback. In the fruit fly Drosophila melanogaster, the wingbeat rhythm is generated myogenically by stretch-activated muscles and hence independently from direct neural input. In this study, we explored if generation and cycle-by-cycle ...
Arora Prem - - 2013
Objective To describe the clinical characteristics and outcomes of neonatal intensive care unit patients with a radiographic diagnosis of pneumatocele.Study Design Retrospective chart review.Results Our cohort (n = 27) had a gestational age of 27 ± 5 weeks, birth weight of 1038 ± 760 g, and a predominance of females (59%) and black infants (74%). All infants were ventilated at ...
Sousa Eduardo H S - - 2013
FixL is a prototype for heme-based sensors: multi-domain proteins that typically couple a histidine protein kinase activity to a heme-binding domain for sensing of diatomic gases such as oxygen, carbon monoxide and nitric oxide. Despite a relatively well-advanced knowledge of FixL, the importance of some of its domains has been ...
Nakasone Kiyoshi - - 2013
The brains of teleost fish exhibit remarkable sexual plasticity throughout their life span. To dissect the molecular basis for the development and reversal of sex differences in the teleost brain, we screened for genes differentially expressed between sexes in the brain of medaka (Oryzias latipes). One of the genes identified ...
Paciorkowski Alex R - - 2013
Some brain malformations have clinical and imaging features that are so specific they lend themselves readily to the diagnosis of a specific syndrome. The autosomal recessive pontocerebellar hypoplasias (PCH) fall into this category. These disorders feature postnatal progressive microcephaly combined with brainstem and cerebellar hemispheres that are hypoplastic at birth, ...
Baselski Vickie - - 2013
Ventilator-associated pneumonia (VAP) is a leading cause of health care-associated infection. It has a high rate of attributed mortality, and this mortality is increased in patients who do not receive appropriate empirical antimicrobial therapy. As a result of the overuse of broad-spectrum antimicrobials such as the carbapenems, strains of Acinetobacter, ...
Tahara Maino - - 2013
Here, we provide direct evidence that the receptor-binding site of measles virus (MV) hemagglutinin protein itself forms an effective conserved neutralizing epitope (CNE). Several receptor-interacting residues constitute the CNE. Thus, viral escape from neutralization has to be associated with loss of receptor-binding activity. Since interactions with both the signaling lymphocyte ...
Kim Paul - - 2013
OBJECTIVE: To investigate the biological and technical success outcomes of implant-supported fixed dental prostheses with and without cantilevers, after a minimum of one year loading. MATERIAL AND METHODS: One hundred and seven subjects with 128 cantilever FDPs (cFDP) supported by 132 implants were compared with 99 individuals with 144 non-cantilever ...
Sartor M M - - 2013
Levels of residual disease (RD) are an independent predictor of progression-free survival (PFS) and overall survival (OS) in patients treated for chronic lymphocytic leukemia (CLL). We modified the international standardized approach (ISA) to RD detection using flow cytometry by developing a single tube 10 color antibody assay. METHOD: A single ...
Zaliaduonyte-Peksiene Diana - - 2013
INTRODUCTION: The development of left ventricular remodelling after acute myocardial infarction is a predictor of heart failure and mortality. The purpose of the present study was to assess whether the polymorphism of angiotensinogen (AGT) gene with threonine (T) instead of methionine (M) at amino acid 235 in exon 2 (M235T) ...
Murakami Jun - - 2013
The pond snail Lymnaea stagnalis is capable of learning taste aversion and consolidating this learning into long-term memory (LTM) that is called conditioned taste aversion (CTA). Previous studies showed that some molluscan insulin-related peptides (MIPs) were upregulated in snails exhibiting CTA. We thus hypothesized that MIPs play an important role ...
Agarwala Anandita - - 2013
A cloned transgenic minipig model of hypercholesterolemia and accelerated atherosclerosis could accelerate discovery of new therapies for atherosclerotic cardiovascular disease (Al-Mashhadi et al., this issue).
Campo Giuseppe M - - 2013
Investigations have suggested degradation of native hyaluronan (HA) into small oligosaccharides as being involved in the development and progression of inflammatory diseases, particularly rheumatoid arthritis (RA). Inflammatory responses occur by modulating the TLR4 and 2, and the CD44 natural HA receptor. As reported recently, the adenosine A2 receptor (A(2A)R) plays ...
Abidi Maheen Z - - 2013
A 57-year-old woman with common variable immune deficiency and liver failure of unknown etiology presented with recurrent fevers over a 5-month period. She was found to have Helicobacter canis bacteremia. Immunocompromised hosts with exposure to cats or dogs may be at risk for infection with this organism, which may be ...
Bere Elling - - 2013
Aims: The purpose of this study is to assess the relationships between trips in nature, gathering of wild plants, fishing and hunting and weight status. Methods: Data from a cross-sectional questionnaire survey of 996 parents of sixth- and seventh-graders from 38 randomly chosen schools in two Norwegian counties. All data ...
Zigdon Hila H Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, - - 2013
Ceramide is a key intermediate in the pathway of sphingolipid biosynthesis and is an important intracellular messenger. We recently generated a ceramide synthase 2 (CerS2) null mouse that cannot synthesize very long acyl chain (C22-C24) ceramides. This mouse displays severe and progressive hepatopathy. Significant changes were observed in the sphingolipid ...
Saber-Ayad Maha M - - 2013
BACKGROUND: The renin-angiotensin-aldosterone system plays a role in physiological and pathological responses of the heart to both static and dynamic exercise. Previous studies showed that the level of angiotensin II is determined by the angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphism.Aim:We aimed in this study to determine the effect of ACE ...
Seeherman Howard J - - 2013
Osteoporosis results in a decrease in bone density, bone quality, and strength throughout the skeleton. Despite systemic therapies, the morbidity and mortality that are associated with hip fractures remain a major consequence of osteoporosis. We used fourteen chronic ovariectomized female cynomolgus monkeys in this study. Six animals received an intraosseous ...
Brewer T D - - 2013
Coral reef fisheries are crucial to the livelihoods of tens of millions of people; yet, widespread habitat degradation and unsustainable fishing are causing severe depletion of stocks of reef fish. Understanding how social and economic factors, such as human population density, access to external markets, and modernization interact with fishing ...
Orozco Helena - - 2013
ABSTRACT: BACKGROUND: Yeast viability and vitality are essential for different industrial processes where the yeast Saccharomyces cerevisiae is used as a biotechnological tool. Therefore, the decline of yeast biological functions during aging may compromise their successful biotechnological use. Life span is controlled by a variety of molecular mechanisms, many of ...
Smyth Wendy - - 2013
ABSTRACT: BACKGROUND: Continued aging of the population is expected to be accompanied by substantial increases in the number of people with dementia and in the number of health care staff required to care for them. Adequate knowledge about dementia among health care staff is important to the quality of care ...
Gjini Erida E School of Mathematics and Statistics, College of Science and Engineering, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK. - - 2013
Systems that generate antigenic variation enable pathogens to evade host immune responses and are intricately interwoven with major pathogen traits, such as host choice, growth, virulence and transmission. Although much is understood about antigen switching at the molecular level, little is known about the cross-scale links between these molecular processes ...
Pogue Janice M - - 2013
BACKGROUND: Central statistical monitoring in multicenter trials could allow trialists to identify centers with problematic data or conduct and intervene while the trial is still ongoing. Currently, there are few published models that can be used for this purpose. PURPOSE: To develop and validate a series of risk scores to ...
Tong Xin X Department of Molecular and Integrative Physiology University of Michigan Medical School Ann Arbor, Michigan 48109, - - 2013
The liver responds to fasting-refeeding cycles by reprogramming expression of metabolic genes. Fasting potently induces one of the key hepatic hormones, fibroblast growth factor 21 (FGF21), to promote lipolysis, fatty acid oxidation, and ketogenesis, whereas refeeding suppresses its expression. We previously reported that the basic leucine zipper transcription factor E4BP4 ...
Rockman Steven - - 2013
In preparing for the threat of a pandemic of avian H5N1 influenza virus, we need to consider the significant delay (4 to 6 months) necessary to produce a strain-matched vaccine. As some degree of cross-reactivity between seasonal influenza vaccines and H5N1 virus has been reported, this was further explored in ...
Wang Su - - 2013
Background: Whether the hematocrit is implicated in the pathogenesis of slow coronary flow (SCF) is not known. Methods: To evaluate the correlation between the hematocrit and SCF, we studied 367 patients with angiographically near-normal coronary arteries. They were divided into four quartiles based on the hematocrit. The corrected thrombolysis in ...
Garcia T S - - 2013
Diabetes affects approximately 4% of world's population and metabolic syndrome has been directly related to obesity. There is a class of nuclear receptors, peroxisome proliferator-activated receptors (PPARs), which controls the metabolism of carbohydrates and lipids. It has been considered an attractive target to treat diabetes and metabolic syndrome. Accordingly, the ...
Qu Fei - - 2013
Silver nanoclusters capped by hyperbranched polyethyleneimine (PEI) have been developed as a highly sensitive fluorescent and colorimetric pH sensor. The probe responds rapidly to pH fluctuations and has such absorption characteristics that the color changes from the colorless or a nearly colorless state to a colored state with increasing acidity, ...
Jayasuriya Raveen L - - 2013
This two-year randomized clinical trial was performed to examine whether the geometry of the cemented femoral prosthesis affects the pattern of strain-adaptive bone remodeling in the proximal aspect of the femur after primary total hip arthroplasty. One hundred and twenty patients were randomized to receive a Charnley (composite-beam), Exeter (double-tapered), ...
Wang Chunsheng - - 2013
Nano-Sn/C composites are ideal anode materials for high energy and power density Li-ion batteries. However, because of the low melting point of Sn and the tendency of grain growth, especially during high temperature carbonization, it has been a significant challenge to create well-dispersed ultra-small Sn nano-particles within a carbon matrix. ...
Davis Matthew J - - 2013
RAC1 is a small, Ras-related GTPase that was recently reported to harbor a recurrent UV-induced signature mutation in melanoma, resulting in substitution of P29 to serine (RAC1(P29S)), ranking this the third most frequently occurring gain-of-function mutation in melanoma. Although the Ras family GTPases are mutated in about 30% of all ...
Hocking Morgan D MD Earth to Ocean Research Group, Department of Biological Sciences, Faculty of Environment, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, Canada, V5A 1S6. - - 2013
A general rule in ecology is that the abundance of species or individuals in communities sharing a common energy source decreases with increasing body size. However, external energy inputs in the form of resource subsidies can modify this size spectrum relationship. Here, we provide the first test of how a ...
Jaarsma Debbie - - 2013
Background: Since the 1970s, the Dutch have been active innovators and researchers in the medical education domain. With regards to the quantity of publications in the medical education literature, the Netherlands rank second among countries in Europe and fourth worldwide over the past years, related to the journals with highest ...
Seal Manas - - 2013
Redox active metals (Fe and Cu) and cofactors (heme) bind to Aβ peptides and react with O(2) in their reduced state leading to oxidative stress in the brain. In this study we cryogenically trap and characterize a Fe-O(2) intermediate, using resonance Raman spectroscopy, involved in reactive oxygen species formation by ...
Guediche Sara - - 2013
Listeners' perception of acoustically presented speech is constrained by many different sources of information that arise from other sensory modalities and from more abstract higher-level language context. An open question is how perceptual processes are influenced by and interact with these other sources of information. In this study, we use ...
Lamp Boris - - 2013
Highly pathogenic Nipah virus (NiV) infections are transmitted via airway secretions and urine, commonly via the respiratory route. Epithelial surfaces represent important replication sites in both primary and systemic infection phases. NiV entry and spread from polarized epithelial cells therefore determine virus entry and dissemination within a new host and ...
Merikanto Ilona - - 2013
In this study, the authors analyzed whether chronotypes, sleep duration, and sleep sufficiency are associated with cardiovascular diseases and type 2 diabetes by using the National FINRISK Study 2007 data (N = 6258), being a representative sample of the population aged 25 to 74 living in five areas of Finland. Health status ...
Suchan Julia - - 2013
By implementing a task that closely resembled a clinical test for diagnosing spatial neglect in stroke patients, Himmelbach et al. ([2006]: Neuroimage 32:1747-1759) found significantly increased activation during active exploration in those cortical areas in healthy subjects that are known to induce spatial neglect in case of a lesion. The ...
Spina Francesco - - 2013
Lenalidomide is effective against relapsed chronic lymphocytic leukemia (CLL). We report the first case of long-term molecular remission with continuous lenalidomide treatment in a young patient with CLL relapsed to multiple treatments. Minimal residual disease was assessed by nested polymerase chain reaction on bone marrow samples with patient-specific primers. A ...
Lee Jeong Yong - - 2013
The fast dynamics generated by the Brownian motion of particles in colloidal drops, and the related relaxation during drying, which play key roles in suspension systems, were investigated incorporating multi-speckle diffusing wave spectroscopy (MSDWS). MSDWS equipment was implemented to analyze the relaxation properties of suspensions under a non-ergodic and non-stationary ...
Kattipattanapong Woraya - - 2013
Objective(1) To compare the rate of surgical site infections in ear surgery between groups with and without hair removal and (2) to study factors associated with surgical site infections.Study DesignA preliminary, randomized, controlled trial.SettingUniversity hospital.Subjects and MethodsThe study was conducted in a group of 136 patients who underwent surgery for ...
Swindle M Michael - - 2013
ABSTRACT The authors have extensive experience in surgery, anesthesia, and perioperative care in both miniature and domestic swine in the research setting. This manuscript describes the techniques that have been developed over the last four decades while developing porcine surgical models and their use in translational research. Swine are conditioned ...
Teng Jing - - 2013
In complex materials, how correlation between charge, spin, and lattice affects the emergent phenomena remains unclear. The newly discovered iron-based high-temperature superconductors and related compounds present to the community a prototype family of materials, where interplay between charge, spin, and lattice degrees of freedom can be explored. With the occurrence ...
Uzawa Takanori T Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan. - - 2013
The possibility of evolving a commonly existing biomolecule into a variety of functional biomolecules has now been realized in the form of aptamers through the development of in vitro selection. In addition to their high affinity and high specificity for the desired targets, aptamers are easily synthesized chemically and can ...
Reyes Steve B - - 2013
The malignant brain cancer glioblastoma multiforme (GBM) displays invasive growth behaviors that are regulated by extracellular matrix (ECM) cues within the neural microenvironment. The cell adhesion and signaling mechanisms that drive GBM invasion remain largely uncharacterized. Here we have utilized human GBM cell lines, primary patient samples, and pre-clinical mouse ...
Ji Xiang - - 2013
In this work, an asymmetric swelling-dissolving process of original sub-micron sized decentered sulfonated polystyrene/silica (SPS/silica) particles in a ternary mixed solvent (water/ethanol/heptane) was first reported. Actinia-like and porous snowman-like SPS/silica composite particles are fabricated through tuning the composition of the ternary mixed solvent. Actinia-like particles, with a silica core embedded ...
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