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Abdelhamed Zakia A ZA Ciliopathy Research Group, Section of Ophthalmology and Neurosciences, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, - - 2013
The ciliopathies are a group of heterogeneous diseases with considerable variations in phenotype for allelic conditions such as Meckel-Gruber syndrome (MKS) and Joubert syndrome (JBTS) even at the inter-individual level within families. In humans, mutations in TMEM67 (also known as MKS3) cause both MKS and JBTS, with TMEM67 encoding the ...
Holmström Fredrik - - 2013
The hepatitis C virus (HCV) nonstructural (NS) 5A protein has been shown to promote viral persistence by interfering with both innate and adaptive immunity. At the same time, the HCV NS5A protein has been suggested as a target for antiviral therapy. In this study, we performed a detailed characterization of ...
Veenemans J - - 2013
We compared 2 chromogenic media (Oxoid Brilliance MRSA 2 agar [Thermo Fisher Scientific] and MRSA-ID [bioMérieux]) for the detection of methicillin-resistant Staphylococcus aureus (MRSA) in 1,368 hospital samples. For both media, broth enrichment was essential to obtain satisfactory diagnostic performance. Although with direct cultures only, the diagnostic performance (particularly sensitivity) ...
Scholten Anouk A Section of Endocrine Surgery, University of California, San Francisco, California 94143, - - 2013
Pheochromocytoma crisis is a feared and potentially lethal complication of pheochromocytoma. We sought to determine the best treatment strategy for pheochromocytoma crisis patients and hypothesized that emergency resection is not indicated. Retrospective cohort study (1993-2011); literature review (1944-2011). Tertiary referral center. There were 137 pheochromocytoma patients from our center and ...
Botelho Salomé Calado SC Center for Biomembrane Research, Department of Biochemistry and Biophysics, Stockholm University, SE-106 91 Stockholm, - - 2013
Sorting of mitochondrial inner membrane proteins is a complex process in which translocons and proteases function in a concerted way. Many inner membrane proteins insert into the membrane via the TIM23 translocon, and some are then further acted upon by the mitochondrial m-AAA protease, a molecular motor capable of dislocating ...
Funk Stefan - - 2013
We report on a major modification of the fundamental electronic band structure of AlAs when grown as a nanoscaled wurtzite crystal. Resonant Raman spectra of individual AlAs-GaAs core-shell nanowires display a resonance between 1.83 and 2.18 eV for the AlAs E(1)(TO) phonon mode. Our findings substantiate the lowest conduction band ...
Zheng Shu-Guang - - 2013
Objective: To assess the value of contrast-enhanced ultrasound (CEUS) in the diagnosis of polypoid lesions of gallbladder (PLGs). Methods: CEUS was performed to 116 patients (mean age, 49.6 years; range, 21-80 years) with PLGs from 8 university hospitals. 9 cases of biliary sludge were proven by surgery and the remaining ...
Sadowska Julita J Institute of Biology, University of Białystok, Świerkowa 20B, Białystok 15-950, Poland. - - 2013
The assimilation capacity (AC) hypothesis for the evolution of endothermy predicts that the maternal basal metabolic rate (BMR) should be positively correlated with the capacity for parental investment. In this study, we provide a unique test of the AC model based on mice from a long-term selection experiment designed to ...
Bastiaens Jesse J Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, New York, - - 2013
Impulse control disorders (ICDs) are potentially serious side effects of dopamine agonist therapy in Parkinson's disease (PD), but prospective data are lacking about their incidence, time course, and risk factors. This work was a 4-year, prospective cohort study of outpatients with PD and no previous ICDs (N = 164). All ...
Yamashita Kei - - 2013
An assemblage of a Tb(iii) ion and two mononuclear [Zn(II)(L)] complexes as antenna chromophores (H(2)L: Schiff base ligand) afforded a luminescent single-molecule magnet. The f-f emission spectrum had partially resolved fine structure which provides detailed information on the magnetic anisotropy of the (7)F(6) ground multiplet of the Tb(iii) ion.
Oscherwitz Jon - - 2013
We previously showed that a multiple antigenic peptide (MAP) vaccine displaying amino acids (aa) 304 to 319 from the 2β2-2β3 loop of protective antigen was capable of protecting rabbits from an aerosolized spore challenge with Bacillus anthracis Ames strain. Antibodies to this sequence, referred to as the loop-neutralizing determinant (LND), ...
Franssen Nicole M G - - 2013
Rh-mediated carbene (co)polymerisation of diazomethane works best in the presence of Rh(III) catalyst precursors, the use of which leads to a significant increase in polymer yield and molecular weight. Chain termination via β-hydride elimination is severely suppressed for these species, although this process does still occur leading to unsaturated chain ...
Skogli Erik Winther - - 2013
The aim of the study was to compare executive processes with pronounced (hot) and less pronounced (cold) emotional salience in medication naïve children and adolescents with ADHD-combined (ADHD-C) and ADHD-inattentive (ADHD-I) subtypes. Thirty-six subjects with ADHD-C, 44 with ADHD-I, and 50 healthy controls between 8 and 17 years were assessed ...
Hayashi Ken'ichiro K Department of Neuroscience (D13), Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan. - - 2013
Myocardin (Mycd), a key factor in smooth muscle cell differentiation, is constitutively located in the nucleus, whereas myocardin-related transcription factors A and B (MRTF-A/B) reside mostly in the cytoplasm and translocate to the nucleus in a Rho-dependent manner. Here, we investigated the nuclear export of Mycd family members. They possess ...
Tremaglio Chadene Z - - 2013
The mechanisms by which the respiratory syncytial virus (RSV) RNA-dependent RNA polymerase (RdRp) initiates mRNA transcription and RNA replication are poorly understood. A previous study, using an RSV minigenome, suggested that the leader (Le) promoter region at the 3' end of the genome has two initiation sites, one at position ...
Yang Guang-Sheng - - 2013
Two S-containing MOFs, interpenetrating and non-interpenetrating , were synthesized by altering solvent size. The nanoporous reveals high selective adsorption for Cu(2+) ions and has been applied as a chromatographic column for separating transition metal ions for the first time.
Kern Wolfgang - - 2013
BACKGROUND: Within the myelodysplastic/myeloproliferative neoplasm (MDS/MPN) category of the WHO (2008), only chronic myelomonocytic leukemia was so far evaluated by multiparameter flow cytometry (MFC). METHODS: To investigate the potential of MFC for MDS/MPNs, unclassifiable (MDS/MPNu), and refractory anemia associated with ring sideroblasts and marked thrombocytosis (RARS-T), we studied 91 patients ...
Marchi Alexandria N - - 2013
Although structural DNA nanotechnology, and especially scaffolded DNA origami, hold great promise for bottom-up fabrication of novel nanoscale materials and devices, concerns about scalability have tempered widespread enthusiasm. Here we report a single-pot reaction where both strands of double-stranded M13-bacteriophage DNA are simultaneously folded into two distinct shapes that then ...
Battle Peter D - - 2013
The structure proposed for Li(11)Nd(18)Fe(4)O(39-δ) (Chen et al. Inorg. Chem. 2012, 51, 8073) on the basis of diffraction and Mössbauer spectral data is compared to that determined previously for Nd(18)Li(8)Fe(5)O(39) (Dutton et al. Inorg. Chem.200847, 11212) using the same techniques. The Mössbauer spectrum reported by Chen et al. has been ...
Mednikov Evgueni G - - 2013
Two previously reported cationic clusters, Au(2)Pd(14) () and AuPd(9) (), obtained by similar reactions of CO/PR(3)-ligated Pd(0) clusters with in the presence of TlPF(6) are shown to be [Tl(2)Pd(14)(CO)(9)(PMe(3))(11)](2+) () and [TlPd(9)(CO)(9)(PPh(3))(6)](+) (), respectively. These clusters ([PF(6)](-) counterion) were prepared without the presence of gold by reactions of either Pd(10)(CO)(12)(PMe(3))(6) ...
Alligier Maud M Unité Mixte de Recherche 1060, Institut National de la Santé et de la Recherche Médicale Laboratoires CarMeN et CENS, Université Lyon 1, 69921 Oullins, - - 2013
The hypothesis of a limited expansion of sc adipose tissue during weight gain provides an attractive explanation for the reorientation of excess lipids toward ectopic sites, contributing to visceral adipose depots and metabolic syndrome. Our objective was to define whether the characteristics of sc adipose tissue influence the partition of ...
Ponnusamy Murugavel M Department of Medicine, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI 02903, - - 2013
Our recent studies showed that contents of necrotic renal proximal tubular cells (RPTC) from 2 × 10(6) cells/ml directly induced death of cultured renal interstitial fibroblasts. However, it remains unknown whether nonlethal number of necrotic RPTC would also alter the fate of renal interstitial fibroblasts. To address this issue, renal ...
Rivara Silvia - - 2013
A systematic modification of the caffeinyl core and substituents of the reference compound (E)-8-(3-chlorostyryl)caffeine led to the 9-deazaxanthine derivative (E)-6-(4-chlorostyryl)-1,3,5,-trimethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4-(3H,5H)-dione (17f) which acts as a dual antagonist of human A2a/MAO-B inhibitor (Ki(A2A) = 260 nM; IC50(MAO-B) = 200 nM; IC50(MAO-A) = 10 μM) and dose dependently counteracts haloperidol-induced catalepsy in ...
Thompson C Shea - - 2013
We present a simple and inexpensive technique for bonding PDMS microfluidic devices. The technique uses only adhesive tape and an oven; plasma bonders and cleanroom facilities are not required. It also produces channels that are immediately hydrophobic, allowing formation of aqueous-in-oil emulsions.
Palacios Gustavo - - 2013
Evolutionary insights into the phleboviruses are limited because of an imprecise classification scheme based on partial nucleotide sequences and scattered antigenic relationships. In this report, the serologic and phylogenetic relationships of the Uukuniemi group viruses and their relationships with other recently characterized tick-borne phleboviruses are described using full-length genome sequences. ...
Allolio Christoph - - 2013
Beyond bulk dielectric relaxation: The experimentally observed time-dependent Stokes shift of a molecular probe (MQ) can be explained by molecular dynamics simulations in combination with DFT calculations. Decomposition of the MD trajectories shows that an important contribution to the time-dependent Stokes shift originates from a group of water molecules that ...
Schon Lew C - - 2013
In patients with Achilles tendinosis, Achilles tendon debridement can be supplemented with flexor hallucis longus tendon transfer. Outcomes have not been studied prospectively in older, sedentary, and overweight patients. Fifty-eight consecutive limbs in fifty-six consecutive older, sedentary patients with insertional or midsubstance Achilles tendinosis were enrolled prospectively and underwent the ...
Lee Jihye - - 2013
Synaptic vesicle fusion mediates communication between neurons and is triggered by rapid influx of Ca(2+). The Ca(2+)-triggering step for fusion is regulated by the synaptic vesicle transmembrane protein Synaptotagmin 1 (Syt1). Syt1 contains two cytoplasmic C2 domains, termed C2A and C2B, which coordinate Ca(2+) binding. Although C2A and C2B share ...
Ramage Benjamin S - - 2013
Tropical forest ecosystems are threatened by habitat conversion and other anthropogenic actions. Timber production forests can augment the conservation value of primary forest reserves, but studies of logging effects often yield contradictory findings and thus inhibit efforts to develop clear conservation strategies. We hypothesized that much of this variability reflects ...
Vajpai Navratna - - 2013
Proteins denature not only at high, but also at low temperature as well as high pressure. These denatured states are not easily accessible for experiment, because usually heat denaturation causes aggregation, whereas cold or pressure denaturation occurs at temperatures well below the freezing point of water or pressures above 5 ...
Richmond Daniel - - 2013
In all eukaryotic cells, DNA is packaged into multiple chromosomes that are linked to microtubules through a large protein complex called a kinetochore. Previous data show that the kinetochores are clustered together during most of the cell cycle, but the mechanism and the biological significance of kinetochore clustering are unknown. ...
Bode Lisa M - - 2013
Strong interindividual differences in the microbial conversion of some dietary polyphenols have been reported. In-depth studies of trans-resveratrol metabolism by human gut microbiota, however, are lacking, and only one bacterial metabolite, namely dihydroresveratrol, has been described. The aim of this study was to elucidate interindividual differences in trans-resveratrol metabolism by ...
Cunningham Mark W MW Jr Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL 32610, USA. - - 2013
Normal pregnancy involves increased renal sodium reabsorption, metabolism, and oxygen consumption, which can cause increased oxidative stress (OS). OS can decrease nitric oxide (NO) bioavailability and cause pregnancy complications. In this study we examined the NO synthases (NOS) and redox state in the kidney cortex and aorta in early (E), ...
Xiao Bin - - 2013
An unexpected C-H activation/C-C cross-coupling reaction has been found to occur between pyridine N-oxides and general nonactivated secondary and even tertiary alkyl bromides. It provides a practically useful approach for the synthesis of alkylated pyridine derivatives. Experimental observations indicated that the C-Br cleavage step involves a radical-type process. Thus, the ...
Troalen Thomas - - 2013
Arterial spin labeling has been developed and used for the quantitative and completely noninvasive assessment of myocardial perfusion in vivo. Here we propose a novel arterial spin labeling method called cine-ASL, which is based on an electrocardiogram-gated steady-pulsed labeling approach combined with simultaneous readout over the cardiac cycle using cine-fast ...
Burke John F - - 2013
To test the hypothesis that neural oscillations synchronize to mediate memory encoding, we analyzed electrocorticographic recordings taken as 68 human neurosurgical patients studied and subsequently recalled lists of common words. To the extent that changes in spectral power reflect synchronous oscillations, we would expect those power changes to be accompanied ...
Hochane Mazène - - 2013
Glomerulonephritis is characterized by the proliferation and apoptosis of mesangial cells (MC). The parathyroid-hormone related protein (PTHrP) is a locally active cytokine that affects these phenomena in many cell types, through either paracrine or intracrine pathways. The aim of this study was to evaluate the effect of both PTHrP pathways ...
Temel Jennifer S - - 2013
PURPOSERates of documentation of end-of-life care preferences in the medical record remain low, even among patients with incurable malignancies. We therefore conducted a two-phase study to develop and assess the effect of electronic prompts to encourage oncology clinicians to document code status in the outpatient electronic health record (EHR) of ...
Kannangai Rajesh - - 2013
The frequencies of 10 opportunistic DNA viruses were determined by multiplex real-time PCR in paired cerebrospinal fluid (CSF) and brain tissue of HIV-infected individuals. In the CSF, viruses were detectable in 45/55 cases: JC virus (JCV) in 62%, Epstein-Barr virus (EBV) in 44%, cytomegalovirus (CMV) in 25%, varicella-zoster virus (VZV) ...
Hagiwara Ken'ichi - - 2013
Transmissible spongiform encephalopathies (TSEs), or prion diseases, are fatal infectious neurodegenerative disorders. Their causative agents are prions which are composed of disease-associated forms of prion protein (PrP(Sc)). Naturally occurring cases of TSEs are found in several mammalian species including humans, sheep, goats, minks, cattle and deer. Prions are also experimentally ...
Hara E S - - 2013
This pilot study introduces a novel vibratory stimulation-based occlusal splint (VibOS) for management of pain related to temporomandibular disorders (TMD). The study sample consisted of 10 patients (mean age: 40·5 ± 13·7 years, male/female: 3/7) who were using stabilisation splints for more than 2 months prior to the study onset and still complained of ...
Ammayappan Arun - - 2013
Vesicular stomatitis virus (VSV) is potent and a highly promising agent for the treatment of cancer. However, translation of VSV oncolytic virotherapy into the clinic is being hindered by its inherent neurotoxicity. It has been demonstrated that selected picornaviral internal ribosome entry site (IRES) elements possess restricted activity in neuronal ...
Wei Peifa - - 2013
Two 2 : 3 copillar[5]arene constitutional isomers were prepared and host-guest complexation of their derivatives with dicarboxylic acid sodium salts in water was investigated.
Labòria Noemi - - 2013
Making light work: Photoactivatable multivalent trisNTA compounds have been developed for the in situ labeling and assembly of His-tagged proteins in time and space. This small light-tunable lock-and-key system offers the opportunity to trigger nanomolar protein interactions, such as receptor clustering, or biotechnological applications, for example, multiprotein arrays.
Taherpour Sharmin - - 2013
The capacity of three different purine bases, viz. 2,6-bis(3,5-dimethylpyrazol-1-yl)purine, 2-(3,5-dimethylpyrazol-1-yl)adenine and 2,6-bis(2-acetyl-1-methylhydrazino)purine, to form metal-ion mediated base pairs with the native nucleobases has been examined. For this purpose, ribonucleosides derived from these bases were incorporated into an intrastrand or a 3'-terminal position of short 2'-O-methyl oligoribonucleotides and the hybridization properties ...
Grady Deborah L DL Department of Biological Chemistry, College of Medicine, University of California, Irvine, California 92697, - - 2013
Longevity is influenced by genetic and environmental factors. The brain's dopamine system may be particularly relevant, since it modulates traits (e.g., sensitivity to reward, incentive motivation, sustained effort) that impact behavioral responses to the environment. In particular, the dopamine D4 receptor (DRD4) has been shown to moderate the impact of ...
Kodama Azusa - - 2013
Contrast-induced nephropathy (CIN), caused by a combination of the direct tubular toxicity of contrast media, a reduction in medullary blood flow, and the generation of reactive oxygen species, is a serious clinical problem. A need exists for effective strategies for its prevention. Thioredoxin-1 (Trx) is a low-molecular-weight endogenous redox-active protein ...
Boissinot Lucie L Nephrology Department, CHU Clemenceau, Caen, - - 2013
Transfer to hemodialysis (HD) is a frequent cause of peritoneal dialysis (PD) cessation. In the present study, we set out to describe the transition period between PD and HD. All patients in 4 centers of Basse-Normandie who had been treated with PD for more than 90 days and who were ...
Losón Oliver C - - 2013
Several mitochondrial outer membrane proteins-Fis1, Mff, MiD49, and MiD51-have been proposed to promote mitochondrial fission by recruiting the GTPase Drp1, but fundamental issues remain concerning their function. A recent study supported such a role for Mff, but not for Fis1. In addition, it is unclear whether MiD49 and MiD51 activate ...
Pidkovka Nataliya N Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, - - 2013
The epithelial sodium channel (ENaC) participates in the regulation of plasma sodium and volume, and gain of function mutations in the human channel cause salt-sensitive hypertension. Roles for the arachidonic acid epoxygenase metabolites, the epoxyeicosatrienoic acids (EETs), in ENaC activity have been identified; however, their mechanisms of action remain unknown. ...
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