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Miyamoto Nobuyoshi - - 2013
Macroscopically anisotropic hydrogels were synthesized by hybridization of poly(N-isopropylacrylamide) with liquid crystalline inorganic nanosheets; their anisotropies in the structure and properties are demonstrated.
Peters Solange - - 2013
PURPOSE OF REVIEW: The review aims at comprehensively discussing our current knowledge on bone metastases incidence in non-small cell lung cancer (NSCLC), their related complications as well as clinical impact in patients suffering from advanced disease. RECENT FINDINGS: After evoking the use of zoledronic acid as the established standard of ...
Vulcano Ettore - - 2013
The proportion of bilateral total knee replacements (BTKR) to unilateral total knee replacement (UTKR) in the United States is increasing. From 1990 to 2004, the use of BTKRs more than doubled for the entire civilian population and almost tripled among the female population. BTKRs can be performed in a single-stage ...
Qin Tian-You - - 2013
The first asymmetric organocatalytic allylic alkylation of 1,2-dihydro-Reissert compounds and Morita-Baylis-Hillman (MBH) carbonates has been developed, which provided a novel protocol to construct enantioenriched functionalized 1,2-dihydroisoquinolines bearing vicinal quaternary and tertiary chiral centers at C-1 position (up to 94% ee, dr > 20 : 1).
Simon Thorsten - - 2013
PURPOSEAlthough intensive multimodal treatment has improved the prognosis of patients with metastatic neuroblastoma, the impact of primary tumor resection on outcome is a matter of medical debate. PATIENTS AND METHODSPatients from the German prospective clinical trial NB97 with stage 4 neuroblastoma and age 18 months or older at diagnosis were ...
Sosunova Ekaterina - - 2013
Precise transcription by cellular RNA polymerase requires efficient removal of onn-cognate nucleotide residues occasionally incorporated. Mis-incorporation causes transcription elongation complex (TEC) to backtrack, releasing single strand 3 prime RNA segment bearing non-cognate residue, which is hydrolyzed by the active center that carries two Mg2+ ions. However, in most X-ray structures ...
Liu Jinglan - - 2013
Abstract Chondromyxoid fibroma is a rare benign tumor accounting for 1-2% of primary bone tumors. Most of the patients are young males in the second and third decades of life. Metaphyses of long bones are predominantly affected. The histology of this tumor is well established, but its genetic mechanism remains ...
Sundaram Jeyapriya Raja - - 2013
The aberrant hyperactivation of Cyclin-dependent kinase 5 (Cdk5), by the production of its truncated activator p25, results in the formation of hyperphosphorylated tau, neuroinflammation, amyloid deposition, and neuronal death in vitro and in vivo. Mechanistically, this occurs as a result of a neurotoxic insult that invokes the intracellular elevation of ...
Marchi Alexandria N - - 2013
Although structural DNA nanotechnology, and especially scaffolded DNA origami, hold great promise for bottom-up fabrication of novel nanoscale materials and devices, concerns about scalability have tempered widespread enthusiasm. Here we report a single-pot reaction where both strands of double-stranded M13-bacteriophage DNA are simultaneously folded into two distinct shapes that then ...
Battle Peter D - - 2013
The structure proposed for Li(11)Nd(18)Fe(4)O(39-δ) (Chen et al. Inorg. Chem. 2012, 51, 8073) on the basis of diffraction and Mössbauer spectral data is compared to that determined previously for Nd(18)Li(8)Fe(5)O(39) (Dutton et al. Inorg. Chem.200847, 11212) using the same techniques. The Mössbauer spectrum reported by Chen et al. has been ...
Mednikov Evgueni G - - 2013
Two previously reported cationic clusters, Au(2)Pd(14) () and AuPd(9) (), obtained by similar reactions of CO/PR(3)-ligated Pd(0) clusters with in the presence of TlPF(6) are shown to be [Tl(2)Pd(14)(CO)(9)(PMe(3))(11)](2+) () and [TlPd(9)(CO)(9)(PPh(3))(6)](+) (), respectively. These clusters ([PF(6)](-) counterion) were prepared without the presence of gold by reactions of either Pd(10)(CO)(12)(PMe(3))(6) ...
Rivara Silvia - - 2013
A systematic modification of the caffeinyl core and substituents of the reference compound (E)-8-(3-chlorostyryl)caffeine led to the 9-deazaxanthine derivative (E)-6-(4-chlorostyryl)-1,3,5,-trimethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4-(3H,5H)-dione (17f) which acts as a dual antagonist of human A2a/MAO-B inhibitor (Ki(A2A) = 260 nM; IC50(MAO-B) = 200 nM; IC50(MAO-A) = 10 μM) and dose dependently counteracts haloperidol-induced catalepsy in ...
Thompson C Shea - - 2013
We present a simple and inexpensive technique for bonding PDMS microfluidic devices. The technique uses only adhesive tape and an oven; plasma bonders and cleanroom facilities are not required. It also produces channels that are immediately hydrophobic, allowing formation of aqueous-in-oil emulsions.
Allolio Christoph - - 2013
Beyond bulk dielectric relaxation: The experimentally observed time-dependent Stokes shift of a molecular probe (MQ) can be explained by molecular dynamics simulations in combination with DFT calculations. Decomposition of the MD trajectories shows that an important contribution to the time-dependent Stokes shift originates from a group of water molecules that ...
Voleti Pramod B - - 2013
Presentations at the Annual Meetings of the American Academy of Orthopaedic Surgeons (AAOS) are often used to guide clinical practice, although many corresponding manuscripts are not published. The purpose of this study was to determine the relationship between level of evidence, rate of publication, and time to publication of presentations ...
Gustafsen Camilla - - 2013
The development and progression of Alzheimer's disease is linked to excessive production of toxic amyloid-β peptide, initiated by β-secretase cleavage of the amyloid precursor protein (APP). In contrast, soluble APPα (sAPPα) generated by the α-secretase is known to stimulate dendritic branching and enhance synaptic function. Regulation of APP processing, and ...
Kolkman Diny G E - - 2013
Objective To assess the ability of the Bishop score to predict the mode of delivery in women scheduled for induction of labor at term.Study Design We performed a systematic literature search of electronic databases from inception to July 2009. Studies reporting on both the Bishop score and the outcome of labor in ...
Close David M - - 2013
For the DNA bases the pK(a)'s of the neutral molecules have been measured, and a review article by Steenken provides a convenient summary of the experimental pK(a)'s of the DNA radical ions. The purpose of the present work is to attempt to calculate the pK(a)'s of the DNA radical ions ...
Mahboubi Hossein - - 2013
ObjectiveTo evaluate and compare the efficacy of commercially available earplugs in preventing water intrusion in healthy individuals.Study DesignExperimental study.SettingTertiary care medical center.Subjects and MethodsTen subjects (20 ears) were assessed. After insertion of the earplugs, subjects underwent 3 standardized head-wetting protocols, including (1) surface swimming for 10 minutes, which entailed no ...
Ngubane Siyabonga - - 2013
A mixed-ligand metal-metal bonded diruthenium complex having the formula Ru(2)(2,4,6-(CH(3))(3)ap)(3)(O(2)CCH(3))Cl where ap is the anilinopyridinate anion was synthesized from the reaction of Ru(2)(O(2)CCH(3))(4)Cl and H(2,4,6-(CH(3))(3)ap), after which the isolated product was structurally, spectroscopically and electrochemically characterized. The crystal structure reveals an unusual arrangement of the bridging ligands around the dimetal ...
Girolami Mauro - - 2013
Common peroneal nerve palsy is an infrequent pathology mostly related to endogenous or exogenous compression. The exogenous compression is frequently related to trauma: knee fractures or hematoma arisen after a direct blow. Fractures may cause a direct lesion of the nerve; hematoma causes a compression of the nerve at the ...
Lauchnor Ellen Grace - - 2013
Strontium-90 is a principal radionuclide contaminant in the subsurface at several Department of Energy sites in the Western US, causing a threat to groundwater quality in areas such as Hanford, WA. In this work, we used laboratory scale porous media flow cells to examine a potential remediation strategy employing co-precipitation ...
Christensen Randilynn - - 2013
The mixed glass former effect (MGFE) is defined as a non-linear and non-additive change in the ionic conductivity with changing glass former composition at constant modifier composition. In this study, sodium borophosphate 0.35 Na2O + 0.65 [xB2O3 + (1-x)P2O5], 0 ≤ x ≤ 1 glasses which have been shown to ...
de Buyl Pierre - - 2013
The fabrication of synthetic self-propelled particles and the experimental investigations of their dynamics have stimulated interest in self-generated phoretic effects that propel nano- and micron-scale objects. Theoretical modeling of these phenomena is often based on a continuum description of the solvent for different phoretic propulsion mechanisms, including, self-electrophoresis, self-diffusiophoresis and ...
Liu Lei - - 2013
Hierarchical FeOOH nanostructure array films constructed by different nanosized building blocks can be synthesized at air-water interface via a bio-inspired gas-liquid diffusion method. In this approach, poly(acrylic acid) (PAA) as a crystal growth modifier plays a crucial role in mediating the morphology and polymorph of FeOOH crystals. With the increase ...
Coëffier Moïse - - 2013
BACKGROUND: Glutamine modulates duodenal protein metabolism in fasted healthy humans, but its effects in a fed state remain unknown. OBJECTIVE: We aimed to assess the effects of either glutamine or an isonitrogenous protein mixture on duodenal protein metabolism in humans in the fed state. DESIGN: Twenty-four healthy volunteers were randomly ...
Basler Tina - - 2013
Mycobacterium avium ssp. paratuberculosis (MAP) causes Johne's disease, a chronic, granulomatous enteritis of ruminants. Dendritic cells (DC) of the gut are ideally placed to combat invading mycobacteria; however, little is known about their interaction with MAP. Here, we investigated the interaction of MAP and the closely related M. avium ssp. ...
Karasoy Deniz - - 2013
AIMS: Trends in patient selection and pharmacotherapy before radiofrequency ablation (RFA) of atrial fibrillation are not well studied. We examined temporal trends in RFA utilization on a nationwide scale in Denmark.METHODS AND RESULTS: Using the cross-linkage of nationwide registers, 3302 atrial fibrillation patients treated with 'first-ever' RFA between 2000 and ...
Schyllander Jan - - 2013
Aims: The goal of this research project was to explore circumstances surrounding each drowning death occurring to children and adolescents ages 0-17 in Sweden during the years 1998-2007. Methods: Records from the National Board of Forensic Medicine (NBFM) and other sources were analysed. We collected information on children's personal characteristics ...
Yang Jui-Jung - - 2013
Intracapsular femoral neck fractures are associated with high rates of nonunion. We aimed to identify risk factors for nonunion in patients with both displaced and nondisplaced intracapsular femoral neck fractures treated with three 7-mm parallel cannulated screws, placed in either a triangle or an inverted triangle configuration, using failure of ...
Born Stephan - - 2013
Bitter taste is a basic taste modality, required to safeguard animals against consuming toxic substances. Bitter compounds are recognized by G-protein-coupled bitter taste receptors (TAS2Rs). The human TAS2R10 responds to the toxic strychnine and numerous other compounds. The mechanism underlying the development of the broad tuning of some TAS2Rs is ...
Fang Yin - - 2013
We report a new solution-deposition method to synthesize an unprecedented type of two-dimensional (2D) ordered mesoporous carbon nanosheets, via a controlled low-concentration monomicelle close packing assembly approach. These obtained carbon nanosheets possess only one layer of ordered mesopores laid on the surface of a substrate, typically the inner walls of ...
Schwarzkopf Ran - - 2013
Knee malalignment during total knee arthroplasty (TKA) is commonly classified as either varus or valgus on the basis of a standing anteroposterior radiograph. Computer-assisted surgery (CAS) navigation TKA provides precise dynamic evaluation of knee alignment throughout the full range of motion (FROM). The goal of this study was to classify ...
Mochida Keiichi - - 2013
Crop plants, whose productivity is affected by a wide range of growing and environmental conditions, are grown for economic purposes. Transcription factors (TFs) play central role in regulation of many biological processes, including plant development and responses to environmental stimuli, by activating or repressing spatiotemporal gene expression. Here, we describe ...
Gómez-Tortosa Estrella - - 2013
OBJECTIVE: Expansions of more than 30 hexanucleotide repetitions in the C9ORF72 gene are a common cause of frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS). However, the range of 20-30 repetitions is rarely found and still has unclear significance. A screening of our cohort of cases with FTD (n = ...
Beneyton T - - 2013
We developed a new covalent enzyme immobilization technique compatible with lithography processes. Carbon nanotube electrodes patterned on glass slides were used to create Y-shaped membraneless glucose/O(2) microfluidic biofuel cells. An original extremophilic laccase, CotA from Bacillus subtilis, was used in the cathodic compartment of these miniaturized biofuel cells.
Manning Lydia K - - 2013
Research suggests that spirituality is important to a large percentage of the older adult population and serves as a promoter of healthy aging. In this qualitative research I conducted and analyzed multiple interviews with 6 women aged 80 and older. Using multiple in-depth interviews I explored the interplay between spirituality ...
Shamsher Areeg A - - 2013
Abstract The focus of the present study was to develop and evaluate the transdermal system of celecoxib. Transdermal gels composed of carbopol 940 in propylene glycol (PG) containing penetration enhancers. The formulations were characterized by permeation, pharmacokinetics, pharmacodynamics and histopathology. Celecoxib permeation across excised rat skins were statistically (p < 0.05) enhanced ...
Lemke Henrik T - - 2013
X-ray Free Electron Lasers (XFELs) deliver short (<100 femtoseconds) and intense (~1e12 photons) pulses of hard X-rays making them a perfect source for time resolved studies. Here we show that, despite the inherent instabilities of current XFELs, they can be used for measuring high quality X-ray absorption data and we ...
Mota Theo - - 2013
Color vision in honey bees (Apis mellifera) has been extensively studied at the behavioral level and, to a lesser degree, at the physiological level by means of electrophysiological intracellular recordings of single neurons. Few visual neurons have been so far characterized in the lateral protocerebrum of bees. Therefore, the possible ...
Andersen Jaron R - - 2013
We reviewed a consecutive series of patients with a humeral fracture around either an anatomic or a reverse shoulder prosthesis treated with either open reduction and internal fixation (ORIF) or revision shoulder arthroplasty. The purposes of the study were to (1) describe the treatment of these fractures by either method, ...
Adum Gilbert Baase - - 2013
There is a lack of quantitative information on the effectiveness of selective-logging practices in ameliorating effects of logging on faunal communities. We conducted a large-scale replicated field study in 3 selectively logged moist semideciduous forests in West Africa at varying times after timber extraction to assess post logging effects on ...
Knickmeyer Rebecca C - - 2013
Studies in adolescents and adults have demonstrated that polymorphisms in putative psychiatric risk genes are associated with differences in brain structure, but cannot address when in development these relationships arise. To determine if common genetic variants in disrupted-in-schizophrenia-1 (DISC1; rs821616 and rs6675281), catechol-O-methyltransferase (COMT; rs4680), neuregulin 1 (NRG1; rs35753505 and ...
Rana Tanmoy - - 2013
Arsenic is one of the most hazardous substances in the environment known to cause toxicity in multiple organs. Cell adhesion, morphological alterations, cell proliferation, terminal deoxyuridine triphosphate nick-end labeling (TUNEL) and caspase-3/CPP32 fluorometric protease assay were important biomarkers to assess apoptosis in cells. This study aimed to evaluate arsenic-induced apoptosis ...
Lin Laiyi - - 2013
Adhesive micropattern arrays permit the continuous monitoring and systematic study of the behavior of spatially confined cells of well-defined shape and size in ordered configurations. This technique has contributed to defining mechanisms that control cell polarity and cell functions, including proliferation, apoptosis, differentiation and migration in two-dimensional cell culture systems. ...
Friederici Angela D - - 2013
Learning takes place throughout lifetime but differs in infants and adults because of the immaturity of the PFC, a brain region responsible for cognitive control. To test this hypothesis, adults were investigated in a language learning paradigm under inhibitory, cathodal transcranial direct current stimulation over PFC. The experiment included a ...
Kirkness Ewen F - - 2013
There is increasing evidence that the phenotypic effects of genomic sequence variants are best understood in terms of variant haplotypes rather than as isolated polymorphisms. Haplotype analysis is also critically important for uncovering population histories, and for the study of evolutionary genetics. Although the sequencing of individual human genomes to ...
Wang Yu-Jing - - 2013
OBJECTIVE: The angiotensinogen (AGT) gene M235T polymorphism has been reported to be associated with myocardial infarction (MI), but previous studies have been inconsistent. The present study aimed at assessing the association of M235T polymorphism in the AGT gene with MI using a meta-analysis. METHODS: We retrieved literature in Google Scholar, ...
Hansel David - - 2013
Persistent activity in cortex is the neural correlate of working memory (WM). In persistent activity, spike trains are highly irregular, even more than in baseline. This seemingly innocuous feature challenges our current understanding of the synaptic mechanisms underlying WM. Here we argue that in WM the prefrontal cortex (PFC) operates ...
Sears Nancy - - 2013
OBJECTIVE: /st>Incidence of adverse events (AEs) among home care patients and preventability ratings were estimated. Risk factors, AE types and factors associated with AEs were identified. DESIGN: /st>This study used a stratified, randomized sample of home care patients discharged in the fiscal year 2004/05. Trained nurse reviewers completed retrospective chart ...
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