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Results 501 - 550 of 3304
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Verma Vinod - - 2013
Embryonic pluripotent stem cells (ePSCs) can generate all somatic cell types, as well as functional gametes. In mouse and rat, derivation of ePSCs from the early epiblast is promoted by the double inhibition ("2i") of mitogen-activated protein kinase kinase (MAP2K), antagonizing FGF signaling, and glycogen synthase kinase 3 (GSK3), stimulating ...
Miyamoto Nobuyoshi - - 2013
Macroscopically anisotropic hydrogels were synthesized by hybridization of poly(N-isopropylacrylamide) with liquid crystalline inorganic nanosheets; their anisotropies in the structure and properties are demonstrated.
Peters Solange - - 2013
PURPOSE OF REVIEW: The review aims at comprehensively discussing our current knowledge on bone metastases incidence in non-small cell lung cancer (NSCLC), their related complications as well as clinical impact in patients suffering from advanced disease. RECENT FINDINGS: After evoking the use of zoledronic acid as the established standard of ...
Vulcano Ettore - - 2013
The proportion of bilateral total knee replacements (BTKR) to unilateral total knee replacement (UTKR) in the United States is increasing. From 1990 to 2004, the use of BTKRs more than doubled for the entire civilian population and almost tripled among the female population. BTKRs can be performed in a single-stage ...
Qin Tian-You - - 2013
The first asymmetric organocatalytic allylic alkylation of 1,2-dihydro-Reissert compounds and Morita-Baylis-Hillman (MBH) carbonates has been developed, which provided a novel protocol to construct enantioenriched functionalized 1,2-dihydroisoquinolines bearing vicinal quaternary and tertiary chiral centers at C-1 position (up to 94% ee, dr > 20 : 1).
Zultanski Susan L SL Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, - - 2013
The first Suzuki cross-couplings of unactivated tertiary alkyl electrophiles are described. The method employs a readily accessible catalyst (NiBr(2)·diglyme/4,4'-di-tert-butyl-2,2'-bipyridine, both commercially available) and represents the initial example of the use of a group 10 catalyst to cross-couple unactivated tertiary electrophiles to form C-C bonds. This approach to the synthesis of ...
Simon Thorsten - - 2013
PURPOSEAlthough intensive multimodal treatment has improved the prognosis of patients with metastatic neuroblastoma, the impact of primary tumor resection on outcome is a matter of medical debate. PATIENTS AND METHODSPatients from the German prospective clinical trial NB97 with stage 4 neuroblastoma and age 18 months or older at diagnosis were ...
Mi Michael Y MY Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Harvard University, Boston, MA, - - 2013
Currently, a growing placebo response rate has been observed in clinical trials for antidepressant drugs, a phenomenon that has made it increasingly difficult to demonstrate efficacy. The sequential parallel comparison design (SPCD) is a clinical trial design that was proposed to address this issue. The SPCD theoretically has the potential ...
Sosunova Ekaterina - - 2013
Precise transcription by cellular RNA polymerase requires efficient removal of onn-cognate nucleotide residues occasionally incorporated. Mis-incorporation causes transcription elongation complex (TEC) to backtrack, releasing single strand 3 prime RNA segment bearing non-cognate residue, which is hydrolyzed by the active center that carries two Mg2+ ions. However, in most X-ray structures ...
Desmet Emily A EA Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, - - 2013
Cellular protein synthesis is suppressed during influenza virus infection, allowing for preferential production of viral proteins. To explore the impact of polymerase subunits on protein synthesis, we coexpressed enhanced green fluorescent protein (eGFP) or luciferase together with each polymerase component or NS1 of A/California/04/2009 (Cal) and found that PA has ...
Liu Jinglan - - 2013
Abstract Chondromyxoid fibroma is a rare benign tumor accounting for 1-2% of primary bone tumors. Most of the patients are young males in the second and third decades of life. Metaphyses of long bones are predominantly affected. The histology of this tumor is well established, but its genetic mechanism remains ...
Sundaram Jeyapriya Raja - - 2013
The aberrant hyperactivation of Cyclin-dependent kinase 5 (Cdk5), by the production of its truncated activator p25, results in the formation of hyperphosphorylated tau, neuroinflammation, amyloid deposition, and neuronal death in vitro and in vivo. Mechanistically, this occurs as a result of a neurotoxic insult that invokes the intracellular elevation of ...
Seredynski Aurore L - - 2013
Estrogens exert pleiotropic effects on reproductive traits, which include differentiation and activation of reproductive behaviors and the control of the secretion of gonadotropins. Estrogens also profoundly affect non-reproductive traits, such as cognition and neuroprotection. These effects are usually attributed to nuclear receptor binding and subsequent regulation of target gene transcription. ...
Kägi Georg - - 2013
A characteristic feature of primary cervical dystonia is the presence of "sensory tricks" as well as the impairment of temporal and spatial sensory discrimination on formal testing. The aim of the present study was to test whether the amount of improvement of abnormal head deviation due to a sensory trick ...
Pham Cong-Dat - - 2013
Four new aaptamine derivatives (1-4) along with aaptamine (5) and three related compounds (6-8) were isolated from the ethanol extract of the sponge Aaptos suberitoides collected in Indonesia. The structures of the new compounds were unambiguously determined by one- and two-dimensional NMR and by HRESIMS measurements. Compounds 3, 5, and ...
Varghese Binny V - - 2013
Uterine fibroids (leiomyomas) are the most common tumors of the female reproductive tract, occurring in up to 77% of reproductive-aged women, yet molecular pathogenesis remains poorly understood. A role for atypically activated mammalian target of rapamycin (mTOR) pathway in the pathogenesis of uterine fibroids has been suggested in several studies. ...
Ali Zeina Z Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institute, - - 2013
The two oxysterols, 27-hydroxycholesterol (27OH) and 24S-hydroxycholesterol (24OH), are both inhibitors of cholesterol synthesis and activators of the liver X receptor (LXR) in vitro. Their role as physiological regulators under in vivo conditions is controversial, however. In the present work, we utilized a previously described mouse model with overexpressed human ...
Brown Arleen F AF Division of General Internal Medicine and Health Services Research, University of California, Los Angeles, USA. - - 2013
Residence in a socioeconomically disadvantaged community is associated with mortality, but the mechanisms are not well understood. We examined whether socioeconomic features of the residential neighborhood contribute to poststroke mortality and whether neighborhood influences are mediated by traditional behavioral and biologic risk factors. We used data from the Cardiovascular Health ...
Saarinen Silva - - 2013
PURPOSENodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is one of the two established Hodgkin lymphoma (HL) subtypes. The risk factors of NLPHL are largely unknown. In general, genetic factors are known to have a modest effect on the risk of HL; however, familial risk in NLPHL has not been previously examined. We ...
Storm Benjamin C - - 2013
Recent research has found that individuals can selectively forget a subset of items through directed forgetting. The goal of the present study was to replicate this selective directed forgetting effect and elucidate its underlying mechanisms. Unfortunately, results from four experiments failed to find any evidence of selective directed forgetting. Participants ...
Zhang Dengsong - - 2013
The MnO(x) and CeO(x) were in situ supported on carbon nanotubes (CNTs) by a poly(sodium 4-styrenesulfonate) assisted reflux route for the low-temperature selective catalytic reduction (SCR) of NO with NH(3). X-Ray diffraction (XRD), transmission electron microscopy (TEM), high-resolution TEM (HRTEM), X-ray photoelectron spectroscopy (XPS), H(2) temperature-programmed reduction (H(2)-TPR) and NH(3) ...
Wong Chun-Ho - - 2013
The concept of orthogonality has been applied to many areas of chemistry, ranging from wave functions to chromatography. But it was Barany and Merrifield's orthogonal protecting group strategy that paved the way for solid phase peptide syntheses, other important classes of biomaterials such as oligosaccharides and oligonucleotides, and ultimately to ...
Wu Rachel R Department of Brain and Cognitive Sciences, University of Rochester, Meliora Hall, Rochester, NY 14627, USA. - - 2013
Visual search is often guided by top-down attentional templates that specify target-defining features. But search can also occur at the level of object categories. We measured the N2pc component, a marker of attentional target selection, in two visual search experiments where targets were defined either categorically (e.g., any letter) or ...
van Wijck Kim - - 2013
Background: Previously, we demonstrated that exercise can cause small intestinal injury, leading to loss of gut barrier function. The functional consequences of such exercise-induced intestinal injury on subsequent food digestion and absorption are unclear. The present study determined the impact of resistance-type exercise on small intestinal integrity and in vivo ...
Chittka Lars - - 2013
Endogenous circadian clocks are synchronized to the 24-h day by external zeitgebers such as daily light and temperature cycles. Bumblebee foragers show diurnal rhythms under daily light:dark cycles and short-period free-running circadian rhythms in constant light conditions in the laboratory. In contrast, during the continuous light conditions of the arctic ...
Wong Linda - - 2013
BACKGROUND: Assays of antigen expression on myeloid cells have an underlying premise that the assay integrates high purity gating of the leukocyte subpopulation in question. While CD45/side scatter (SSC) gating provides sufficient gating purity for qualitative assays of antigen expression; it is unsuitable for quantitative assays of antigen changes, especially ...
Avila Humar Alberto - - 2013
Composite materials made of epoxy resin and barium titanate (BT) electrospun nanostructured fibers were prepared. BT fibers were synthesized from a sol based on barium acetate, titanium isopropoxide and poly(vinyl pyrrolidone). The fibers were heat-treated at different temperatures and characterized by X-ray diffraction, scanning electron microscopy (SEM) and Raman spectroscopy. ...
Voleti Pramod B - - 2013
Presentations at the Annual Meetings of the American Academy of Orthopaedic Surgeons (AAOS) are often used to guide clinical practice, although many corresponding manuscripts are not published. The purpose of this study was to determine the relationship between level of evidence, rate of publication, and time to publication of presentations ...
Gustafsen Camilla - - 2013
The development and progression of Alzheimer's disease is linked to excessive production of toxic amyloid-β peptide, initiated by β-secretase cleavage of the amyloid precursor protein (APP). In contrast, soluble APPα (sAPPα) generated by the α-secretase is known to stimulate dendritic branching and enhance synaptic function. Regulation of APP processing, and ...
Kerstein Patrick C PC Department of Neuroscience and Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin 53706, - - 2013
Intracellular Ca(2+) signals control the development and regeneration of spinal axons downstream of chemical guidance cues, but little is known about the roles of mechanical cues in axon guidance. Here we show that transient receptor potential canonical 1 (TRPC1) subunits assemble mechanosensitive (MS) channels on Xenopus neuronal growth cones that ...
Kolkman Diny G E - - 2013
Objective To assess the ability of the Bishop score to predict the mode of delivery in women scheduled for induction of labor at term.Study Design We performed a systematic literature search of electronic databases from inception to July 2009. Studies reporting on both the Bishop score and the outcome of labor in ...
Ashhad Sufyan S Cellular Neurophysiology Laboratory, Molecular Biophysics Unit, Indian Institute of Science, Bangalore, - - 2013
The A-type potassium current has been implicated in the regulation of several physiological processes. Here, we explore a role for the A-type potassium current in regulating the release of calcium through inositol trisphosphate receptors (InsP3R) that reside on the endoplasmic reticulum (ER) of hippocampal pyramidal neurons. To do this, we ...
Tolppanen Anna-Maija - - 2013
Stroke increases the risk of dementias, including Alzheimer disease (AD), but it is unknown whether persons with AD have a higher risk of strokes. We investigated whether noninstitutionalized persons with AD were more likely to experience incident stroke than persons without AD and whether there are differences in the incidence ...
Neuman Melissa M Departments of Society, Human Development, and Health, Harvard School of Public Health, Boston, MA 02115, USA. - - 2013
Urbanization is often cited as a main cause of increasing BMIs in low- and middle-income countries (LMICs), and urban residents in LMICs tend to have higher BMIs than do rural residents. However, urban-rural differences may be driven by differences in socioeconomic status (SES). Using nationally representative data collected at 2 ...
Close David M - - 2013
For the DNA bases the pK(a)'s of the neutral molecules have been measured, and a review article by Steenken provides a convenient summary of the experimental pK(a)'s of the DNA radical ions. The purpose of the present work is to attempt to calculate the pK(a)'s of the DNA radical ions ...
Mahboubi Hossein - - 2013
ObjectiveTo evaluate and compare the efficacy of commercially available earplugs in preventing water intrusion in healthy individuals.Study DesignExperimental study.SettingTertiary care medical center.Subjects and MethodsTen subjects (20 ears) were assessed. After insertion of the earplugs, subjects underwent 3 standardized head-wetting protocols, including (1) surface swimming for 10 minutes, which entailed no ...
Hansel David - - 2013
Persistent activity in cortex is the neural correlate of working memory (WM). In persistent activity, spike trains are highly irregular, even more than in baseline. This seemingly innocuous feature challenges our current understanding of the synaptic mechanisms underlying WM. Here we argue that in WM the prefrontal cortex (PFC) operates ...
Haynes Kyle J KJ The Blandy Experimental Farm, University of Virginia, 400 Blandy Farm Lane, Boyce, VA 22620, USA. - - 2013
Despite the pervasiveness of spatial synchrony of population fluctuations in virtually every taxon, it remains difficult to disentangle its underlying mechanisms, such as environmental perturbations and dispersal. We used multiple regression of distance matrices (MRMs) to statistically partition the importance of several factors potentially synchronizing the dynamics of the gypsy ...
Sears Nancy - - 2013
OBJECTIVE: /st>Incidence of adverse events (AEs) among home care patients and preventability ratings were estimated. Risk factors, AE types and factors associated with AEs were identified. DESIGN: /st>This study used a stratified, randomized sample of home care patients discharged in the fiscal year 2004/05. Trained nurse reviewers completed retrospective chart ...
Melot Brent C - - 2013
To meet the growing global demand for energy while preserving the environment, it is necessary to drastically reduce the world's dependence on non-renewable energy sources. At the core of this effort will be the ability to efficiently convert, store, transport and access energy in a variety of ways. Batteries for ...
Martinez Cantarin Maria P MP Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. - - 2013
Adiponectin has antidiabetic properties, and patients with obesity, diabetes, and insulin resistance have low plasma adiponectin levels. However, although kidney disease is associated with insulin resistance, adiponectin is elevated in end-stage renal disease. Here we determine whether adipose tissue production of adiponectin is increased in renal disease in a case-control ...
Ehlert Gregory John - - 2013
Low interface strength is a persistent problem in composite materials and cascades to limit a variety of bulk material properties such as lamina shear strength. Whiskerization has long been pursued as a method to reinforce the interphase and improve both the single fiber interface strength as well as the bulk ...
Crespo María I - - 2013
ssRNA can interact with dendritic cells (DCs) through binding to TLR7, inducing secretion of proinflammatory cytokines and type I IFN. Triggering TLR7 enhances cross-priming of CD8(+) T cells, which requires cross-presentation of exogenous Ag to DCs. However, how TLR triggering can affect Ag cross-presentation is still not clear. Using OVA ...
Jones David K DK Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia V5A 1S6, - - 2013
Protons impart isoform-specific modulation of inactivation in neuronal, skeletal muscle, and cardiac voltage-gated sodium (Na(V)) channels. Although the structural basis of proton block in Na(V) channels has been well described, the amino acid residues responsible for the changes in Na(V) kinetics during extracellular acidosis are as yet unknown. We expressed ...
Zhang Jinzhu - - 2013
A new twist: A one-pot nitrous acid free, diazonium-free, and transition-metal-free variation of the Fischer indole synthesis has been developed. Condensation of quinone monoketals and aliphatic hydrazine hydrochlorides afforded indoles via intermediate alkylaryldiazenes. This method will complement the classical Fischer indole synthesis by providing indoles in two steps from widely ...
Rong Yu Y Department of Chemistry, University of Washington, Seattle, Washington 98195, - - 2013
Fluorescent semiconducting polymer dots (Pdots) have attracted great interest because of their superior characteristics as fluorescent probes, such as high fluorescence brightness, fast radiative rates, and excellent photostability. However, currently available Pdots generally exhibit broad emission spectra, which significantly limit their usefulness in many biological applications involving multiplex detections. Here, ...
Fulgoni Victor L VL - - 2013
ABSTRACT: BACKGROUND: Avocados contain monounsaturated fatty acids (MUFA) dietary fiber, essential nutrients and phytochemicals. However, no epidemiologic data exist on their effects on diet quality, weight management and other metabolic disease risk factors. The objective of this research was to investigate the relationships between avocado consumption and overall diet quality, ...
Schwacke John H - - 2013
New insights into the intrarenal renin-angiotensin (Ang) system have modified our traditional view of the system. However, many finer details of this network of peptides and associated peptidases remain unclear. We hypothesized that a computational systems biology approach, applied to peptidomic data, could help to unravel the network of enzymatic ...
DesJardin Jacqueline T - - 2013
Stimulation of the intermediate and deep layers of superior colliculus (DLSC) in rodents evokes both orienting/pursuit (approach) and avoidance/flight (defense) responses (Dean et al., 1989). These two classes of response are subserved by distinct output projections associated with lateral (approach) and medial (defense) DLSC (Comoli et al., 2012). In non-human ...
Flühe Leif - - 2013
The Sporulation Killing Factor (SKF) is a 26-residue ribosomally assembled and posttranslationally modified sactipeptide. It is produced by Bacillus subtilis 168 and plays a key role in its sporulation. As all sactipeptides, SKF contains a thioether bond, which links the cysteine residue Cys4 with the α-carbon of the methionine residue ...
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