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Marcilla Miguel - - 2013
Many physiological processes are regulated by dynamic protein interaction networks whose characterization provides valuable information on cell biology. Several strategies can be used to analyze protein-protein interactions. Among them, affinity purification combined with mass spectrometry (AP-MS) is arguably the most widely employed technique, not only owing to its high throughput ...
Ziaei M - - 2013
Prevention of slipping accidents requires provision of adequate friction through the use of suitable combinations of footwear and underfoot surfaces. Shoe sole tread groove is one of the important factors on friction coefficient during walking. To measure the effect of different shoe sole tread groove depths and different surfaces on ...
Miura Yoshinori - - 2013
The precursor protein of localized cutaneous amyloidosis (LCA) is believed to be cytokeratins on the basis of previous immunohistochemical studies. To identify the candidate amyloid protein biochemically, amyloid proteins were extracted with distilled water from lesional skin of LCA associated with Bowen's disease. The proteins were resolved on one- or ...
Deguine Jacques - - 2013
Natural killer (NK) cells are innate lymphocytes endowed with the capacity to survey and eliminate infected and transformed cells. Like T cells and B cells, NK cells fulfill their task by responding to soluble factors and to signals exchanged during cell-cell contacts. In this respect, cellular interactions established by NK ...
Taylor Christopher A - - 2013
Fatal infectious disease acquired during international travel is less likely to be captured through existing surveillance when diagnosis is delayed or missed, especially as autopsy rates decline. Death of a young girl owing to malaria demonstrates needs for increased examination of travel-related deaths through postmortem investigation, autopsy, and expanded surveillance.
Nienhaus G Ulrich - - 2013
Engineered nanoparticles (NPs) have found widespread application in technology and medicine. Whenever they come in contact with a living organism, interactions take place between the surfaces of the NPs and biomatter, in particular proteins, which are currently not well understood. We have introduced fluorescence correlation spectroscopy (FCS) and dual-focus FCS ...
Angevine Peter D - - 2013
The routine practice of neurosurgery generates a large amount of clinical data. The structured, systematic capture of this information using clinical registries or other rigorously designed observational studies can yield useful evidence to help improve the care of patients. Registries in particular can be designed to measure outcomes in real-world ...
Huisman Annemiek - - 2013
Until recently, suicides of mental health care users in the Netherlands had to be reported to the Health Care Inspectorate by treating clinicians and medical directors. Interview data from 38 clinicians who reported a suicide and directors of the 28 facilities where they worked indicated ambivalence about the procedure's usefulness, ...
Rosales Luis - - 2013
: In this work, we present a theoretical study of the transport properties of two finite and parallel armchair graphene nanoribbons connected to two semi-infinite leads of the same material. Using a single Π-band tight binding Hamiltonian and based on Green's function formalisms within a real space renormalization techniques, we ...
Abbas R A - - 2013
Informal employment is common in developing countries, including Egypt. This type of employment may have significant consequences on mental health. To determine the prevalence and risk factors of common mental disorders and substance abuse among temporary hired hospital cleaners. A cross-sectional study was conducted on 242 adult temporary cleaners and ...
Skorupski Nicole - - 2013
The purpose of this article is to increase awareness of osteoporosis incidence in patients with hip fracture among providers and allied health professionals, to increase osteoporosis recognition and treatment in post hip-fracture patients, and to provide guidance on how to improve continuity of care and collaboration between members of the ...
Grabowski Gregory - - 2013
Iliac crest bone graft has long been the standard adjunct used in spine fusion surgery. This graft provides osteogenic, osteoinductive, and osteoconductive elements that aid in creation of a fusion mass. However, morbidity associated with bone graft harvest has led surgeons to seek other potential adjuncts, including bone morphogenetic proteins, ...
Karnieli-Miller Orit - - 2013
Context  White coat ceremonies (WCCs) are widely prevalent as a celebration of matriculation in medical schools. Critics have questioned whether these ceremonies can successfully combine the themes of professionalism and humanism, as well as whether the white coat is an appropriate symbol. Objectives  This study aimed to add a process ...
Harrison Jon F - - 2013
Insect tracheal-respiratory systems achieve high fluxes and great dynamic range with low energy requirements and could be important models for bioengineers interested in developing microfluidic systems. Recent advances suggest that insect cardiorespiratory systems have functional valves that permit compartmentalization with segment-specific pressures and flows and that system anatomy allows regional ...
Felekyan Suren - - 2013
Fluorescence correlation spectroscopy (FCS) in combination with Förster resonance energy transfer (FRET) has been developed to a powerful statistical tool, which allows for the analysis of FRET fluctuations in the huge time of nanoseconds to seconds. FRET-FCS utilizes the strong distance dependence of the FRET efficiency on the donor (D)-acceptor ...
Groman Rachel F - - 2013
In an effort to rein in spending and improve patient outcomes, the US government and the private sector have adopted a number of policies over the last decade that hold health care professionals increasingly accountable for the cost and quality of the care they provide. A major driver of these ...
Appelbaum Paul S - - 2013
Anders Breivik's murder of 77 people in Norway in 2011 led to an unusual clash of interests. With conflicting psychiatric reports regarding his sanity, prosecutors argued that Breivik should be found not guilty by reason of insanity, whereas the defense strongly maintained that he was sane and responsible for his ...
Yaffe Michael B - - 2013
With input from the members of the Board of Reviewing Editors and editorial staff, Science Signaling puts the spotlight on the hottest signaling research of 2012. The connection between signaling and metabolism continues to be an important area. Signaling breakthroughs in cancer, immunology, developmental biology, neuroscience, and microbiology all made ...
Toyota Masatsugu - - 2013
Mechanical stress is a critical signal affecting morphogenesis and growth and is caused by a large variety of environmental stimuli such as touch, wind, and gravity in addition to endogenous forces generated by growth. On the basis of studies dating from the early 19th century, the plant mechanical sensors and ...
Piselli P - - 2013
Organ transplantation is an increasingly used medical procedure for treating otherwise fatal end-stage organ diseases with 107,000 transplants performed worldwide in 2010. A large number of newly developed anti-rejection drugs were developed. They prolong long-term survival of both the individual and the transplanted organ and constitute the main reason of ...
Jungbauer Alois - - 2013
This annual Methods and Advances Special Issue of Biotechnology Journal contains a selection of cutting-edge research and review articles with a particular emphasis on vertical process understanding - read more in this editorial by Prof. Alois Jungbauer, BTJ co-Editor-in-Chief.
Kim Mina - - 2013
Human dermal fibroblasts (HDFs) regulate wound-healing processes in human skin, including the regeneration of skin sensory fibres, in response to various mechanical stimuli. Because nerve growth factor (NGF) has an essential role in sensory regeneration, we evaluated the possible association of NGF with mechanical stimulus-dependent cellular responses in HDFs. A ...
Cumming Toby B - - 2013
Cognitive impairment after stroke is common and can cause disability with major impacts on quality of life and independence. There are also indirect effects of cognitive impairment on functional recovery after stroke through reduced participation in rehabilitation and poor adherence to treatment guidelines. In this article, we attempt to establish ...
Ochiai Hideo - - 2013
Glutathione S-transferase (GST) was found to complex with the Na(+) ,K(+) -ATPase as shown by binding assay using quartz crystal microbalance. The complexation was obstructed by the addition of antiserum to the α-subunit of the Na(+) ,K(+) -ATPase, suggesting the specificity of complexation between GST and the Na(+) ,K(+) -ATPase. ...
Minsky Shula - - 2013
This study investigated concordance between self-perceived and measured weight status for persons with serious mental illness. A total of 586 mental health clients assessed their weight as underweight, normal, overweight, or obese. The agreement between these self-assessments and the same categories based on measured body mass index was related to ...
Aziz Q - - 2013
Background  The microbial community of the human gut - the enteric microbiota - plays a critical role in functions that sustain health and is a positive asset in host defenses. In recent years, our understanding of this so-called human 'super organism' has advanced, following characterization of fecal metagenomes which identified ...
Purbhoo Marco A - - 2013
The immune synapse is central to the regulation of T-cell activation and effector functions. Vesicular compartments dynamically interact with the immune synapse. Here they take part in the trafficking of signaling components to and from the synaptic cleft, as well as in the directed delivery and release of T-cell effector ...
Yardley Sarah - - 2013
Context  Authentic early experience (AEE) describes experiences provided to new medical students to undertake 'human contact' to enhance learning. Although the concept of AEE is not new, and was commonplace prior to the Flexner Report of 1910, little is known about how or why meaning and knowledge are constructed through ...
Eisenberg Bob - - 2013
Ionic solutions are dominated by interactions because they must be electrically neutral, but classical theory assumes no interactions. Biological solutions are rather like seawater, concentrated enough so that the diameter of ions also produces important interactions. In my view, the theory of complex fluids is needed to deal with the ...
Li Huifang - - 2013
Androgen receptor (AR) plays a critical role in the development and progression of prostate cancer (PCa). The AR hormone-binding site (HBS) is intensively studied and represents the target area for the current antiandrogens including Bicalutamide and structurally related Enzalutamide. As resistance to antiandrogens invariably emerges in advanced prostate cancer, there ...
Bhardwaj M - - 2013
Noise, one of the major environmental nuisances, affects the learning ability of children negatively. With the assumption that in the existing German 4-type school system children are exposed to various noise levels in each type of school, we investigated the association between children's school type and environmental noise level. In ...
Oishi Motoharu - - 2013
The koala (Phascolarctos cinereus) and southern hairy-nosed wombat (Lasiorhinus latifrons) are iconic Australian fauna that share a close phylogenetic relationship but there are currently no comparative studies of the seminiferous epithelial cell or testicular microanatomy of either species. Koala and wombat spermatozoa are unusual for marsupials as they possess a ...
Pascal M - - 2013
Despite the frequency and severity of peanut allergy, the only approved treatment is strict avoidance. Different types of immunotherapy with crude peanut extract are not universally effective and have been associated with relatively high adverse reaction rates. We sought to determine whether in silico predictive algorithms were useful in identifying ...
Dixon Austin - - 2013
The introduction of retrievable inferior vena cava (IVC) filters was an important step in the evolution of deep vein thrombosis/pulmonary embolism management. Their removability makes them preferred to permanent filters in many cases. IVC filter retrieval often occurs at a suboptimal rate, leading to complications associated with long-term placement. Improving ...
Zhu Wancheng - - 2013
Hollow or porous hematite (α-Fe2O3) nanoarchitectures have emerged as promising crystals in the advanced materials research. In this contribution, hierarchical mesoporous α-Fe2O3 nanoarchitectures with a pod-like shape were synthesized via a room-temperature coprecipitation of FeCl3 and NaOH solutions, followed by a mild hydrothermal treatment (120°C to 210°C, 12.0 h). A ...
Vázquez-Ortiz M - - 2013
Strict avoidance is the only accepted management for cow's milk (CM) allergy. CM oral immunotherapy (CM-OIT) is under investigation. To evaluate long-term safety of CM-OIT. To identify clinical/immunological predictors of adverse events. Prospective longitudinal epidemiological intervention study. CM-allergic children aged 5-18 underwent a Spanish-approved CM-OIT protocol without premedication. Clinical data, ...
Ozulken Kemal - - 2013
Purpose: To review recent advancements in applications of the femtosecond (FS) laser in ophthalmology. Design: Literature review and commentary. Results: With the FS laser, it is now possible to produce a more precise flap diameter, hinge and depth of the flap in laser in situ keratomileusis surgery. Recently, the FS laser ...
Ko Jennifer S - - 2013
A neutrophil-predominant inflammatory infiltrate in a cutaneous biopsy can be associated with a broad spectrum of diseases. Here we describe three cases showing a neutrophil-predominant dermal infiltrate admixed with abundant acellular bodies surrounded by capsule-like vacuolated spaces, which strikingly mimicked Cryptococcus. Two cases occurred within the settings of underlying hematologic ...
Husain Qasim - - 2013
With its inception nearly half a century ago through the pioneering work of Dandy, McLean, and Smith, anterior skull base (ASB) surgery is a relatively young discipline. It became a distinct entity in 1963 when Ketcham popularized the combined transcranial transfacial approach for en bloc resection of tumors of the ...
Gao Junlan - - 2013
Sterols (cholesterol and phytosterols) are important structural components of cell membranes and major constituents of lipid metabolism. The research of their oxides, such as the factors affecting oxidation, oxides' structures, qualitative and quantitative analysis etc., aroused more attention in this decade. However, the biological roles of individual phytosterol oxides are ...
Briganti Stefania - - 2013
Azelaic acid (AzA) has been used for the treatment for inflammatory skin diseases, such as acne and rosacea. Interestingly, an improvement in skin texture has been observed after long-time treatment with AzA. We previously unrevealed that anti-inflammatory activity of AzA involves a specific activation of PPARγ, a nuclear receptor that ...
Tetin Sergey Y - - 2013
Antibodies are excellent binding proteins that have found numerous applications in biological research, biotechnology, and medicine. Characterization of their ligand binding properties has long been, and continues to be, the focus of many researchers. Antibodies are also perfect test systems which can be used for the evaluation of newly introduced ...
Berkowitz Oren - - 2013
Object The first North American 201 cobalt-60 source Gamma Knife surgery (GKS) device was introduced at the University of Pittsburgh Medical Center in 1987. The introduction of this innovative and largely untested surgical procedure prompted the desire to study patient outcomes and evaluate the effectiveness of this technique. The parallel ...
Tsai Jack - - 2013
OBJECTIVE The Health Care for Reentry Veterans (HCRV) program provides Veterans Health Administration outreach services to veterans incarcerated in state and federal prisons. This study used HCRV data to compare risk of incarceration of veterans of Operations Enduring Freedom (OEF), Iraqi Freedom (OIF), and New Dawn (OND) and other veterans ...
Tunsaringkarn T - - 2013
For its toxicity, benzene exposure is one of the main health concerns for high risk occupations like gasoline station workers. However, there is little knowledge about the effect of benzene metabolites on hematological parameters. To evaluate the correlation between the urinary level of trans, trans-muconic acid (t, t-MA), a benzene ...
Koch Werner - - 2013
Relatively low numbers of kringle 4 type 2 repeats in apolipoprotein(a) and specific haplotypes of the SLC22A3-LPAL2-LPA region on chromosome 6 are associated with an increased risk of coronary disease. We examined the possibility that rs3798220 and rs10455872, short variations located in LPA [the apolipoprotein(a) gene], and related to the ...
Mahnken Jonathan D - - 2013
Baseline and trend data for oral and pharyngeal cancer incidence is limited. A new algorithm was derived using the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database to create an algorithm to identify incident cases of oral and pharyngeal cancer using Medicare claims. Using a split-sample approach, Medicare claims' procedure ...
Svinti Victoria - - 2013
Every year the human population encounters epidemic outbreaks of influenza, and history reveals recurring pandemics that have had devastating consequences. The current work focuses on the development of a robust algorithm for detecting influenza strains that have a composite genomic architecture. These influenza subtypes can be generated through a reassortment ...
Våge Dag I - - 2013
A genome wide association study for litter size in Norwegian White Sheep (NWS) was conducted using the recently developed ovine 50K SNP chip from Illumina. After genotyping 378 progeny tested artificial insemination (AI) rams, a GWAS analysis was performed on estimated breeding values (EBVs) for litter size. A QTL-region was ...
Velpandian Thirumurthy - - 2013
The polyherbal eye drop (Itone™) is a mixture of aqueous distillates of nineteen traditionally used ingredients that sum up to impart potency to the formulation and make it a useful adjunct in various ocular pathologies. However, as there have been no controlled experimental studies accounting to the above claim, therefore, ...
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