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Zhang Ruan - - 2013
Tregs expressing the transcription factor FOXP3 are critical for immune homeostasis. The costimulatory molecule CD28 is required for optimal activation and function of naive T cells; however, its role in Treg function has been difficult to dissect, as CD28 is required for thymic Treg development, and blockade of CD28-ligand interactions ...
Canneyt Koen Van - - 2013
Double lumen (DL) central venous catheters (CVC) often suffer from thrombosis, fibrin sheet formation, and/or suction towards the vessel wall, resulting in insufficient blood flow during hemodialysis. Reversing the catheter connection often restores blood flows, but will lead to higher recirculation. Single lumen (SL) CVCs have often fewer flow problems, ...
Ken Soléakhéna - - 2013
ABSTRACT: BACKGROUND: To integrate 3D MR spectroscopy imaging (MRSI) in the treatment planning system (TPS) for glioblastoma dose painting to guide simultaneous integrated boost (SIB) in intensity-modulated radiation therapy (IMRT). METHODS: For sixteen glioblastoma patients, we have simulated three types of dosimetry plans, one conventional plan of 60-Gy in 3D ...
Kumode Takahiro - - 2013
Abstract Primary effusion lymphoma (PEL) is a rare type of non-Hodgkin lymphoma that usually develops in immunosuppressed patients infected with human herpes virus 8 (HHV8) in conjunction with human immunodeficiency virus (HIV) infection. However, there are several reports of HHV-8-related HIV-negative cases and HHV8-unrelated HIV-negative cases, mainly in immunodeficient and ...
Alexander B S BS Irvine School of Medicine, University of California, Irvine, CA, - - 2013
While the decrease in blood carbon dioxide (CO2 ) secondary to hyperventilation is generally accepted to play a major role in the decrease of cerebral tissue oxygen saturation (SctO2 ), it remains unclear if the associated systemic hemodynamic changes are also accountable. Twenty-six patients (American Society of Anesthesiologists I-II) undergoing ...
Lee Jungkyu K - - 2013
Back and forth: Enzymatic, reversible polymerization on gold surfaces was efficiently carried out from surface-tethered self-priming oligodeoxynucleotides in a sequence-specific fashion by using two kinds of enzymes. Taq DNA polymerase, acting as a catalyst, facilitated DNA polymerization, and DNA restriction enzymes cut DNA polymers from the surface.
Nagase Hiroaki - - 2013
OBJECTIVE: To identify predictors of the development of neurologic damage in children with febrile seizures or altered consciousness within 6 hours of onset. METHODS: Our study included 86 children (4-159 months old), who fulfilled the diagnostic criteria for complex febrile seizures on admission to our department between October 2002 and ...
Ma R - - 2013
Gliomas are the most common primary central nervous system tumour seen in adults. There have been many advances over the last two decades as we widen our search for a molecular basis of gliomagenesis. Many biomarkers have been discovered to be important in the management of gliomas, including 1p19q co-deletion, ...
Fan Ya-Chi YC Department of Pediatrics, Chung Gung Memorial Hospital, Taoyuan, - - 2013
This study aimed to develop an applicable oral training protocol and test its effects on vital sign stabilisation in premature infants. Oral training improves the feeding behaviour of premature infants. However, the inconsistencies of oral training procedures in previous studies obscure the interventional effect of oral training on vital sign ...
Müller Christoph R - - 2013
Enzymes create chiral microenvironments that may simultaneously generate several stereogenic centers in the same catalytic cycle, broadening the possibilities of biocatalysis. Benzaldehyde lyase (BAL) affords highly diastereoselective α-hydroxy-ketones by simultaneously performing ligation and kinetic resolution of a racemic aldehyde. Thus, to the well-known enantioselective BAL-carboligation of aldehydes (C-C bond formation), ...
Hollóczki Oldamur - - 2013
Carbon dioxide-ionic liquid systems are of great current interest, and significant efforts have been made lately to understand the intermolecular interactions in these systems. In general, all the experimental and theoretical studies have concluded so far that the main solute-solvent interaction takes effect through the anion, and the cation has ...
Kouatli Yasser - - 2013
This case report illustrates the challenges in managing patients with centrifugal ventricular assist devices (VADs). As these devices have evolved, their physical properties have changed, impacting patient management. Levitated centrifugal pumps have a non-linear response to afterloads. The device output will decrease significantly in the presence of high systemic vascular ...
George Alfred L AL Jr Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA. - - 2013
The abrupt cessation of effective cardiac function due to an aberrant heart rhythm can cause sudden and unexpected death at any age, a syndrome called sudden cardiac death (SCD). Annually, more than 300,000 cases of SCD occur in the United States alone, making this a major public health concern. Our ...
Foss Francine M - - 2013
ABSTRACT This phase II study to determine the safety and efficacy of denileukin diftitox (DD) and CHOP enrolled patients with newly diagnosed peripheral T-cell lymphoma (PTCL). Forty-nine received DD 18 µg/kg/day (days 1, 2) with CHOP (day 3) every 21 days ≤6-8 cycles. Intent-to-treat (ITT) and safety populations comprised all ...
Giaroni C - - 2013
Background  Intestinal ischemia and reperfusion (I/R) injury leads to abnormalities in motility, namely delay of transit, caused by damage to myenteric neurons. Alterations of the nitrergic transmission may occur in these conditions. This study investigated whether an in vitro I/R injury may affect nitric oxide (NO) production from the myenteric ...
Quiat Daniel D Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9148, - - 2013
The management of cardiovascular risk through lifestyle modification and pharmacotherapy is paramount to the prevention of cardiovascular disease. Epidemiological studies have identified obesity, dyslipidemia, diabetes, and hypertension as interrelated factors that negatively affect cardiovascular health. Recently, genetic and pharmacological evidence in model systems has implicated microRNAs as dynamic modifiers of ...
Al-Khatib Sana M SM Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA. - - 2013
Randomized clinical trials have shown that implantable cardioverter-defibrillator (ICD) therapy saves lives. Whether the survival of patients who received an ICD in primary prevention clinical trials differs from that of trial-eligible patients receiving a primary prevention ICD in clinical practice is unknown. To determine whether trial-eligible patients who received a ...
Elwell Laura - - 2013
Objective This study was designed to examine patients' and health professionals' perspectives on lifestyle behaviour change and to inform the development of a lifestyle behaviour change intervention to be used in primary care. Design Focus groups were conducted with seven patients and 13 health professionals where they were asked to ...
Stegmayr Bernd G - - 2013
Background: The blood membrane interaction induced during hemodialysis (HD) activates the coagulation system. To prevent clotting and to maintain dialyzer patency, an anticoagulant such as tinzaparin is used. To increase patency of the dialyzers and to reduce the risk of bleeding related to anticoagulation, citrate-containing dialysate has been introduced in ...
- - 2013
Due to privacy restrictions, the SRTR no longer has access to Social Security death data. We take a look at what this means for transplantation research and patient care, and at possible solutions. Also this month, we recount some of the papers written by 2012 Nobel laureate Alvin E. Roth ...
Thallinger Barbara - - 2013
With the increasing prevalence of antibiotic resistance, antimicrobial enzymes aimed at the disruption of bacterial cellular machinery and biofilm formation are under intense investigation. Several enzyme-based products have already been commercialized for application in the healthcare, food and biomedical industries. Successful removal of complex biofilms requires the use of multi-enzyme ...
Ferreira J J - - 2013
To summarize the 2010 EFNS/MDS-ES evidence-based treatment recommendations for the management of Parkinson's disease (PD). This summary includes the treatment recommendations for early and late PD. For the 2010 publication, a literature search was undertaken for articles published up to September 2009. For this summary, an additional literature search was ...
Bruschi Giuseppe - - 2013
Transcatheter aortic valve implantation has been designed to treat patients affected by severe symptomatic aortic stenosis considered extremely high risk for surgical aortic valve replacement. The CoreValve® (Medtronic Inc., MN, USA) is a multilevel self-expanding and fully radiopaque nitinol frame with a diamond cell configuration that holds a trileaflet porcine ...
Allmark Peter - - 2013
Virtue ethics is often proposed as a third way in health-care ethics, that while consequentialism and deontology focus on action guidelines, virtue focuses on character; all three aim to help agents discern morally right action although virtue seems to have least to contribute to political issues, such as austerity. I ...
Koch Werner - - 2013
Relatively low numbers of kringle 4 type 2 repeats in apolipoprotein(a) and specific haplotypes of the SLC22A3-LPAL2-LPA region on chromosome 6 are associated with an increased risk of coronary disease. We examined the possibility that rs3798220 and rs10455872, short variations located in LPA [the apolipoprotein(a) gene], and related to the ...
Wei Yong - - 2013
The global metabolic regulator catabolite repression control (Crc) has recently been found to modulate the susceptibility to antibiotics and virulence in the opportunistic pathogen Pseudomonas aeruginosa and been suggested as a nonlethal target for novel antimicrobials. In P. aeruginosa, Crc couples with the CA motifs from the small RNA CrcZ ...
Whitehead Cynthia - - 2013
Context:  The dominance of biomedical science in medical education has been contested throughout the past century, with recurring calls for more social science and humanities content. The centrality of biomedicine is frequently traced back to Abraham Flexner's 1910 report, 'Medical Education in the United States and Canada'. However, Flexner advocated ...
Bhardwaj M - - 2013
Noise, one of the major environmental nuisances, affects the learning ability of children negatively. With the assumption that in the existing German 4-type school system children are exposed to various noise levels in each type of school, we investigated the association between children's school type and environmental noise level. In ...
Oishi Motoharu - - 2013
The koala (Phascolarctos cinereus) and southern hairy-nosed wombat (Lasiorhinus latifrons) are iconic Australian fauna that share a close phylogenetic relationship but there are currently no comparative studies of the seminiferous epithelial cell or testicular microanatomy of either species. Koala and wombat spermatozoa are unusual for marsupials as they possess a ...
Tuppo L L Institute of Protein Biochemistry, CNR, Naples, Italy; Center for Molecular Allergology, IDI-IRCCS, Rome, - - 2013
Among the peach-derived allergens which are already known, the lipid transfer protein (Pru p 3) seems to be the one to exert severe allergic reactions. To identify and characterize a new peach allergen causing a clinical picture similar to that of Pru p 3. Patients were selected on the basis ...
Tajalli Raziye - - 2013
Helicobacter pylori, which is associated with many upper gastrointestinal diseases, is found in half of the population of the world. Several special stains and immunohistochemistry stain for H. pylori are available. The need for and usefulness of immunohistochemical (IHC) technique has been debated for years. Toluidine blue is a simple ...
Ciesielski Artur - - 2013
Self-assembly of small molecular modules interacting through non-covalent forces is increasingly being used to generate functional structures and materials for electronic, catalytic, and biomedical applications. The greatest control over the geometry in H-bond supramolecular architectures, especially in H-bonded supramolecular polymers, can be achieved by exploiting the rich programmability of artificial ...
Jungbauer Alois - - 2013
This annual Methods and Advances Special Issue of Biotechnology Journal contains a selection of cutting-edge research and review articles with a particular emphasis on vertical process understanding - read more in this editorial by Prof. Alois Jungbauer, BTJ co-Editor-in-Chief.
Kim Mina - - 2013
Human dermal fibroblasts (HDFs) regulate wound-healing processes in human skin, including the regeneration of skin sensory fibres, in response to various mechanical stimuli. Because nerve growth factor (NGF) has an essential role in sensory regeneration, we evaluated the possible association of NGF with mechanical stimulus-dependent cellular responses in HDFs. A ...
Cumming Toby B - - 2013
Cognitive impairment after stroke is common and can cause disability with major impacts on quality of life and independence. There are also indirect effects of cognitive impairment on functional recovery after stroke through reduced participation in rehabilitation and poor adherence to treatment guidelines. In this article, we attempt to establish ...
Ochiai Hideo - - 2013
Glutathione S-transferase (GST) was found to complex with the Na(+) ,K(+) -ATPase as shown by binding assay using quartz crystal microbalance. The complexation was obstructed by the addition of antiserum to the α-subunit of the Na(+) ,K(+) -ATPase, suggesting the specificity of complexation between GST and the Na(+) ,K(+) -ATPase. ...
Minsky Shula - - 2013
This study investigated concordance between self-perceived and measured weight status for persons with serious mental illness. A total of 586 mental health clients assessed their weight as underweight, normal, overweight, or obese. The agreement between these self-assessments and the same categories based on measured body mass index was related to ...
Aziz Q - - 2013
Background  The microbial community of the human gut - the enteric microbiota - plays a critical role in functions that sustain health and is a positive asset in host defenses. In recent years, our understanding of this so-called human 'super organism' has advanced, following characterization of fecal metagenomes which identified ...
Schamel Wolfgang W A - - 2013
SUMMARY: Despite the low affinity of the T-cell antigen receptor (TCR) for its peptide/major histocompatibility complex (pMHC) ligand, T cells are very sensitive to their antigens. This paradox can be resolved if we consider that the TCR may be organized into pre-existing oligomers or nanoclusters. Such structures could improve antigen ...
Sutton Karen M - - 2013
The rate of anterior cruciate ligament (ACL) rupture is three times higher in female athletes than in male athletes. Intrinsic factors such as increased quadriceps angle and increased posterior tibial slope may predispose girls and women to ACL injury. Compared with males, females have smaller notch widths and smaller ACL ...
Di Bella A - - 2013
To determine if proteinuria is more common in dogs with lymphoma when compared with healthy dogs and to assess the severity and frequency of proteinuria in dogs with lymphoma. Determination of urine protein:creatinine ratio in 32 dogs with lymphoma compared with 30 healthy dogs. Canine patients with lymphoma are more ...
Rees Charlotte E - - 2013
OBJECTIVES  Although previous studies have explored medical learners''most memorable' experiences, these have typically focused on patient deaths or mistakes. Drawing on multiple theoretical perspectives to understand the interplay between narrative, emotion and action, this paper aims to explore the whats and hows of written narratives of most memorable professionalism dilemmas: ...
Javadi Yalda - - 2013
Mechanical forces regulate the function of numerous proteins relevant to physiology. The functions and folding of proteins have been under scrutiny for decades, but it was not until recently that mechanical forces have been considered. Here, we review different techniques for studying protein folding, highlighting their physiological significance.
Ségard Emilie M - - 2013
OBJECTIVE: (1) To describe the ultrasonographic appearance of multiple congenital ocular anomalies (MCOA) in the eyes of horses with the PMEL17 (Silver) mutant gene. (2) To compare the accuracy of B-mode ocular ultrasound to conventional direct ophthalmoscopy. ANIMALS STUDIED: Sixty-seven Comtois and 18 Rocky Mountain horses were included in the ...
Graca Joao - - 2013
OBJECTIVE: This study examined demographic and clinical characteristics of frequent users of a psychiatric inpatient unit in Portugal. METHODS: Data (2004-2008) for 1,348 consecutive psychiatric inpatients were reviewed. Frequent users (N=137), who had at least three admissions in the study period, were compared with nonfrequent users (N=1,211) on age, gender, ...
Shirasaki Yoshitaka - - 2013
The immune system is a very complex and dynamic cellular system, and its intricacies are considered akin to those of human society. Disturbance of homeostasis of the immune system results in various types of diseases; therefore, the homeostatic mechanism of the immune system has long been a subject of great ...
Tunsaringkarn T - - 2013
For its toxicity, benzene exposure is one of the main health concerns for high risk occupations like gasoline station workers. However, there is little knowledge about the effect of benzene metabolites on hematological parameters. To evaluate the correlation between the urinary level of trans, trans-muconic acid (t, t-MA), a benzene ...
Ding Boyang - - 2013
Spectral and directional reshaping of fluorescence from dye molecules embedded in self-assembled hybrid plasmonic-photonic crystals has been examined. The hybrid crystals comprise 2-dimensional hexagonal arrays of dye-doped dielectric nanospheres, capped with silver semi-shells. Comparing the reshaped fluorescence spectra with measured transmission/reflection spectra and numerical calculations reveals that the spectral and ...
Wright Phillip C - - 2013
As we move further into the postgenomics age where the mountain of systems biology-generated data keeps growing, as does the number of genomes that have been sequenced, we have the exciting opportunity to understand more deeply the biology of important systems, those that are amenable to genetic manipulation and metabolic ...
Motawei S M - - 2013
Lead toxicity is a prevalent health problem in both developed and developing countries. One of the proposed mechanisms for lead-induced organ damage is oxidative stress. Oxidative stress is well-associated with the pregnancy disorder, pre-eclampsia. Exposure to lead may be one of the sources of the oxidative stress that leads to ...
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