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Yashiro Masatomo - - 2013
Purpose: Bioimpedance spectroscopy (BIS) is widely used to assess fluid status in hemodialysis (HD) patients. Our purpose is to evaluate filtration coefficients (Lpst) as an alternative test to assess fluid status by utilizing BIS as a reference test.
Methods: 106 HD patients (determined group) were divided into two groups with (EX ...
Behrmann-Godel Jasminca - - 2013
SUMMARY Identification of parasite species is particularly challenging in larval and juvenile hosts, and this hampers the understanding of parasite acquisition in early life. The work described here employs a new combination of methods to identify parasite species and study parasite succession in fry of perch (Perca fluviatilis) from Lake ...
Masuda Paula Y - - 2013
Background: The epidemiology and clinical features of brachioradial pruritus are variably described in the literature. We sought to analyze these features in a large group of Brazilian patients. Patients and Methods: In a descriptive, observational study, we identified all patients with a final diagnosis of brachioradial pruritus seen over a ...
Zhu Jianxi - - 2013
ABSTRACT: BACKGROUND: The inactivation of c-Jun N-terminal kinase (JNK) is associated with anti-apoptotic and anti-inflammatory effects in cerebral ischemia, which can be induced by an imbalance between upstream phosphatases and kinases.Result: Mitogen-activated protein kinase phosphatase 7 (MKP-7) was upregulated significantly at 4 h of reperfusion postischemia in rat hippocampi. By ...
Takahashi Daijiro - - 2013
BACKGROUND: The measurement of soluble fibrin monomer complex (SFMC) and fibrin monomer (FM) are well known as markers for a hypercoagulability state, but such measurements have not been investigated in detail for the neonate. To discern a hypercoagulability state among sick newborns, we studied the behavior of SFMC with special ...
Teets Thomas S - - 2013
Oxygenation of Ir(2)(II,II)(tfepma)(2)(CN(t)Bu)(2)Cl(3)H (, tfepma = CH(3)N[P(OCH(2)CF(3))(2)](2)) furnishes Ir(2)(II,II)(tfepma)(2)(CN(t)Bu)(2)Cl(3)(OOH) (), the first isolable iridium hydroperoxo complex. This complex transfers an oxygen atom to triphenylphosphine, producing triphenylphosphine oxide and Ir(2)(II,II)(tfepma)(2)(CN(t)Bu)(2)Cl(3)(OH) () in high yield. Reaction of with acid induces cleavage of the O-O bond, initially forming [Ir(2)(II,II)(tfepma)(2)(CN(t)Bu)(2)Cl(3)(OH(2))]Cl (), which was identified ...
Assaf Chalid - - 2013
Background: Systemic treatment with pegylated liposomal doxorubicin is an established second-line treatment of advanced cutaneous T-cell lymphoma. Pegylated liposomal doxorubicin (PLD) is currently unavailable, therefore, clinical studies investigating the efficacy of non-pegylated liposomal formula (NPLD) have been analyzed. Methods: Since clinical trials comparing PLD and NPLD in CTCL do not ...
Cooney Adeline - - 2013
AIMS AND OBJECTIVES: To understand the meaning of chronic obstructive pulmonary disease (COPD) for people and their response to this disease. BACKGROUND: COPD is a major cause of disability and death. The symptoms of COPD have the potential to impact on every aspect of a person's day-to-day life. To date ...
Bishop D V M - - 2013
Background:  Our ability to look at structure and function of a living brain has increased exponentially since the early 1970s. Many studies of developmental disorders now routinely include a brain imaging or electrophysiological component. Amid current enthusiasm for applications of neuroscience to educational interventions, we need to pause to consider ...
Ortiz Fernanda - - 2013
Background: TGF-β1 expression has been described to increase along with time from transplantation and has also been linked to allograft dysfunction and toxic effects of cyclosporine. Our aim was to correlate intragraft TGF-β1 expression with cyclosporine exposure after kidney transplantation.
Methods: Altogether 53 kidney allograft protocol biopsies from 42 patients on ...
Totaro Pasquale - - 2013
Propeller-like [Fe(4)(L)(2)(dk)(6)] complexes, in which Hdk is a β-diketone and H(3)L is a tripodal alcohol, R-C(CH(2)OH)(3), exhibit tunable magnetic anisotropy barriers and retain their magnetic memory effect when chemically anchored on metal surfaces. Heteronuclear analogues of these M(4) complexes have been sought to afford a library of compounds with different ...
Foss Francine M - - 2013
ABSTRACT This phase II study to determine the safety and efficacy of denileukin diftitox (DD) and CHOP enrolled patients with newly diagnosed peripheral T-cell lymphoma (PTCL). Forty-nine received DD 18 µg/kg/day (days 1, 2) with CHOP (day 3) every 21 days ≤6-8 cycles. Intent-to-treat (ITT) and safety populations comprised all ...
Giaroni C - - 2013
Background  Intestinal ischemia and reperfusion (I/R) injury leads to abnormalities in motility, namely delay of transit, caused by damage to myenteric neurons. Alterations of the nitrergic transmission may occur in these conditions. This study investigated whether an in vitro I/R injury may affect nitric oxide (NO) production from the myenteric ...
Ertl Gerhard - - 2013
Scratching the surface: For over 100 years the interactions of molecules at surfaces have been studied at the Fritz Haber Institute of the Max Planck Society, Berlin. Nobel Laureate Gerhard Ertl looks back at some of the key developments in this time, and the people who made them.
Karuputhula Narendra Babu - - 2013
Studies on elevated reactive oxygen species (ROS) levels in granulosa cells (GC) and its subsequent effect on fertilization are limited. Oxidative stress (OS) mediated alterations in GC of infertile women undergoing in vitro fertilization (IVF) and embryo transfer (ET) was investigated. GC were obtained from 28 women with endometriosis (Group ...
Stephansson Olof - - 2013
Maternal psychiatric disease is associated with adverse pregnancy outcomes. Use of selective serotonin reuptake inhibitors (SSRIs) during pregnancy has been associated with congenital anomalies, neonatal withdrawal syndrome, and persistent pulmonary hypertension of the newborn. However, the risk of stillbirth and infant mortality when accounting for previous maternal psychiatric disease remains ...
Torimoto Keiichi - - 2013
ABSTRACT: BACKGROUND: Fluctuations in blood glucose level cause endothelial dysfunction and play a critical role in onset and/or progression of atherosclerosis. We hypothesized that fluctuation in blood glucose levels correlate with vascular endothelial dysfunction and that this relationship can be assessed using common bedside medical devices. METHODS: Fluctuations in blood ...
Belling Franziska - - 2013
Purpose: Thrombin mediates an excess in the production of neoangiogenetic (VEGF) and profibrotic (PAI-1) factors in human peritoneal mesothelial cells (HMC). The mechanisms leading to this overproduction have not been elucidated so far; in the context of peritoneal dialysis it can result in impaired peritoneal membrane function. 
Objectives: This study ...
Lester Jean - - 2013
PURPOSE: This study characterizes drug safety-related label changes by evidence source contribution, time from drug approval to label change, initiator (FDA or sponsor), and drug class. METHODS: A retrospective review of the FDA's internal files was used to obtain regulatory documentation on drugs undergoing a 2010 label change. Contribution of ...
Fakhratova Malika - - 2013
ABSTRACT Purpose: To determine the cause of Leber congenital amaurosis (LCA) in a consanguineous Emirati family. Methods: The clinical diagnosis was made on the basis of medical history, ophthalmoscopy and standard ERG. The diagnosis was confirmed by molecular genetic analysis of known LCA genes by Next-Generation Sequencing (NGS). The latter ...
Abu-Kishk Ibrahim - - 2013
BACKGROUND: It is common practice for patients to be admitted to the intensive care unit following scoliosis surgery, because of the prolonged anesthesia, the need for efficient pain control and the known immediate postoperative complications. However, this may be unnecessary in many patients. PURPOSE: We aimed to establish possible associations ...
Elwell Laura - - 2013
Objective This study was designed to examine patients' and health professionals' perspectives on lifestyle behaviour change and to inform the development of a lifestyle behaviour change intervention to be used in primary care. Design Focus groups were conducted with seven patients and 13 health professionals where they were asked to ...
Stegmayr Bernd G - - 2013
Background: The blood membrane interaction induced during hemodialysis (HD) activates the coagulation system. To prevent clotting and to maintain dialyzer patency, an anticoagulant such as tinzaparin is used. To increase patency of the dialyzers and to reduce the risk of bleeding related to anticoagulation, citrate-containing dialysate has been introduced in ...
Danielsen Anne K - - 2013
AIMS AND OBJECTIVES: To examine patients' experiences of impact of a temporary stoma on their everyday life. Furthermore, we wanted to generate new knowledge and comprehension of learning how to live with a temporary stoma. BACKGROUND: There are many aspects, largely unexplored, that may influence patients' adaptation to life with ...
Lewis Fiona M - - 2013
Background: Neonatal screening for galactosaemia (GAL) identifies the condition early, but subsequent biomedical and genetic testing fails to identify which subgroup of infants with GAL are at most risk of the language disorders associated with the condition. This study aims to present preliminary data on an infant with GAL based ...
Golus Joanna - - 2013
Objectives: This study aims to examine biofilm formed on vascular prostheses by Staphylococcus epidermidis with different ica and aap genetic status, and to evaluate the effect of antibiotic-modified prostheses on bacterial colonization.
Methods: Biofilm formation was determined using fluorescence microscopy imaging. Quantitative analysis was conducted using the biofilm coverage ratio (BCR) ...
Li Qiongyu - - 2013
The growth of bilayer and multilayer graphene on copper foils was studied by isotopic labeling of the methane precursor. Isotope-labeled graphene films were characterized with micro-Raman mapping and Time-of-Flight Secondary Ion Mass Spectrometry (TOF SIMS). During growth at high temperature the adlayers formed simultaneously and beneath the top, continuous layer ...
Krishnakumar S - - 2013
The objective of this study was to determine the duration for which sperm from the North American bison (Bison bison) could be chilled prior to being cryopreserved, without compromising post- thaw sperm quality. This would permit transport of samples collected remotely, to the laboratory (at 4°C) for cryopreservation. Epididymal sperm ...
Drago Lorenzo - - 2013
Purpose: Staphylococcus aureus and Pseudomonas aeruginosa are frequently isolated from biofilm-associated orthopedic implant infections. This study assessed the activity of N-acetyl-L-cysteine at inhibitory and subinhibitory concentrations against biofilm formed by S. aureus and P. aeruginosa on prosthetic materials.
Methods: S. aureus and P. aeruginosa biofilm on smooth polyethylene and sand-blasted titanium ...
Bueters Tjerk - - 2013
Abstract 1. Intestinal loss, 1 - (F(obs)/f(H)), is the missing fraction of the dose that is unexplained by systemic clearance. Here, we investigated whether intestinal loss in rat is predictive for human, and whether intestinal metabolism explained observed differences between rat and human. 2. For 81 marketed drugs, human and rat intestinal loss values ...
Hounton Sennen - - 2013
ABSTRACT: Current methods for estimating maternal mortality lack precision, and are not suitable for monitoring progress in the short run. In addition, national maternal mortality ratios (MMRs) alone do not provide useful information on where the greatest burden of mortality is located, who is concerned, what are the causes, and ...
Avalos Alicia - - 2013
Abstract Silver nanoparticles (AgNPs), which have well-known antimicrobial properties, are extensively used in various medical and general applications. Despite the widespread use of AgNPs, relatively few studies have been undertaken to determine the toxicity effects of AgNPs exposure. The aim of the present work was to study how AgNPs interact ...
Ikeda Mari - - 2013
The effects of the structures of HgX(2) complexes (X = CF(3)SO(3) and Cl) with chiral bidentate ligands [(R)-(-)-1-(1-naphthyl)-N,N-bis(pyridin-4-ylmethyl)ethanamine, (R)-(+)-1-phenyl-N,N-bis(pyridin-4-ylmethyl)ethanamine, (R)-(-)-1-(1-naphthyl)-N,N-bis(pyridin-3-ylmethyl)ethanamine, and (R)-(+)-1-phenyl-N,N-bis(pyridin-4-ylmethyl)ethanamine] on circular dichroism (CD) spectra are reported. The CD spectra of free (R)-(-)- and (R)-(+)-, which have 4-pyridyl groups, are similar to those of (R)-(-)- and (R)-(+)-, which ...
Hollóczki Oldamur - - 2013
Carbon dioxide-ionic liquid systems are of great current interest, and significant efforts have been made lately to understand the intermolecular interactions in these systems. In general, all the experimental and theoretical studies have concluded so far that the main solute-solvent interaction takes effect through the anion, and the cation has ...
Yamada Kazunari - - 2013
Clear cell sarcoma (CCS) is an aggressive soft tissue malignant tumor characterized by a unique t(12;22) translocation that leads to the expression of a chimeric EWS/ATF1 fusion gene. However, little is known about the mechanisms underlying the involvement of EWS/ATF1 in CCS development. In addition, the cellular origins of CCS ...
Amore Alessia - - 2013
Incorporation of cleavable linkers into peptides and proteins is of particular value in the study of biological processes. Here we describe the synthesis of a cleavable linker that is hypersensitive to oxidative cleavage as the result of the periodate reactivity of a vicinal amino alcohol moiety. Two strategies directed towards ...
Al-Khatib Sana M - - 2013
Randomized clinical trials have shown that implantable cardioverter-defibrillator (ICD) therapy saves lives. Whether the survival of patients who received an ICD in primary prevention clinical trials differs from that of trial-eligible patients receiving a primary prevention ICD in clinical practice is unknown. To determine whether trial-eligible patients who received a ...
Zhang Ruan - - 2013
Tregs expressing the transcription factor FOXP3 are critical for immune homeostasis. The costimulatory molecule CD28 is required for optimal activation and function of naive T cells; however, its role in Treg function has been difficult to dissect, as CD28 is required for thymic Treg development, and blockade of CD28-ligand interactions ...
Slight Samantha R - - 2013
One third of the world's population is infected with Mycobacterium tuberculosis (Mtb). Although most infected people remain asymptomatic, they have a 10% lifetime risk of developing active tuberculosis (TB). Thus, the current challenge is to identify immune parameters that distinguish individuals with latent TB from those with active TB. Using ...
Liu Liang Q - - 2013
The Consolidated Standards of Reporting Trials (CONSORT) statement was developed to improve the reporting quality of randomized controlled trials (RCTs). Our primary aim was to assess to what extent reports of RCTs in solid organ transplantation adhere to the 2010 CONSORT statement. Secondly, we investigated the relationship between CONSORT adherence, ...
Seo Ji Hae - - 2013
Oligodendrocyte precursor cells (OPCs) are thought to maintain homeostasis and contribute to long-term repair in adult white matter; however, their roles in the acute phase after brain injury remain unclear. Mice that were subjected to prolonged cerebral hypoperfusion stress developed white matter demyelination over time. Prior to demyelination, we detected ...
Lugli Enrico - - 2013
Long-lived memory T cells are able to persist in the host in the absence of antigen; however, the mechanism by which they are maintained is not well understood. Recently, a subset of human T cells, stem cell memory T cells (TSCM cells), was shown to be self-renewing and multipotent, thereby ...
Flegal Katherine M - - 2013
Estimates of the relative mortality risks associated with normal weight, overweight, and obesity may help to inform decision making in the clinical setting. To perform a systematic review of reported hazard ratios (HRs) of all-cause mortality for overweight and obesity relative to normal weight in the general population. PubMed and ...
Carson Jeffrey L - - 2013
Is a lower vs higher hemoglobin threshold best for minimizing both red blood cell use and adverse clinical outcomes when used to trigger red blood cell transfusions in anemic patients in critical care and acute care settings? Compared with higher hemoglobin thresholds, a hemoglobin threshold of 7 or 8 g/dL ...
McNally Elizabeth M EM Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA. - - 2013
Genetic mutations account for a significant percentage of cardiomyopathies, which are a leading cause of congestive heart failure. In hypertrophic cardiomyopathy (HCM), cardiac output is limited by the thickened myocardium through impaired filling and outflow. Mutations in the genes encoding the thick filament components myosin heavy chain and myosin binding ...
Anversa Piero P Department of Anesthesia and Division of Cardiovascular Medicine, 75 Francis Street, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA. - - 2013
This article discusses current understanding of myocardial biology, emphasizing the regeneration potential of the adult human heart and the mechanisms involved. In the last decade, a novel conceptual view has emerged. The heart is no longer considered a postmitotic organ, but is viewed as a self-renewing organ characterized by a ...
George Alfred L AL Jr Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA. - - 2013
The abrupt cessation of effective cardiac function due to an aberrant heart rhythm can cause sudden and unexpected death at any age, a syndrome called sudden cardiac death (SCD). Annually, more than 300,000 cases of SCD occur in the United States alone, making this a major public health concern. Our ...
Quiat Daniel D Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9148, - - 2013
The management of cardiovascular risk through lifestyle modification and pharmacotherapy is paramount to the prevention of cardiovascular disease. Epidemiological studies have identified obesity, dyslipidemia, diabetes, and hypertension as interrelated factors that negatively affect cardiovascular health. Recently, genetic and pharmacological evidence in model systems has implicated microRNAs as dynamic modifiers of ...
Hajjar Roger J RJ Cardiovascular Research Center, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1030, New York, New York 10029, USA. - - 2013
Advances in understanding the molecular basis of myocardial dysfunction, together with the evolution of increasingly efficient gene transfer technology, make gene-based therapy a promising treatment option for heart conditions. Cardiovascular gene therapy has benefitted from recent advancements in vector technology, design, and delivery modalities. There is a critical need to ...
Soubrier Florent F Genetics Department, Hospital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, and UMR_S 956 UPMC-INSERM. 91 bvd de l’hôpital, Paris, France. - - 2013
Angiotensin I-converting enzyme (ACE, or DCP1) is a zinc metallopeptidase that converts angiotensin I into the vasoactive and aldosterone-stimulating peptide angiotensin II and cleaves bradykinin into inactive peptides. Plasma ACE measurement is widely used for the diagnosis of sarcoidosis. While enzyme concentrations are highly stable in an individual, there is ...
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