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- - 2013
Rigid cluster decomposition along the thermal unfolding trajectory of α-actalbumin is determined by constraint network analysis, as presented by Christopher Pfleger, Sebastian Radestock, Elena Schmidt, and Holger Gohlke on page 220. Rigid clusters are depicted as uniformly colored bodies, with the blue body representing the largest cluster. Hydrogen bonds and ...
Starr Marlene E ME Department of Surgery, University of Kentucky, Lexington, KY 40536-0298, - - 2013
Tolerance to physiological stress resulting from inflammatory disease decreases significantly with age. High mortality rates, increased cytokine production, and pronounced thrombosis are characteristic complications of aged mice with acute systemic inflammation induced by injection with lipopolysaccharide (LPS). As adipose tissue is now recognized as an important source of cytokines, we ...
Alessi Sheila M SM Calhoun Cardiology Center, University of Connecticut Health Center, Farmington, CT, - - 2013
Contingency management (CM) uses tangible incentives to systematically reinforce abstinence and is among the most efficacious psychosocial substance abuse treatments. This study assessed the feasibility and initial efficacy of a portable CM procedure designed to address technical limitations for detecting drinking that have prevented using CM for alcohol problems. Participants ...
- - 2013
The conformational space of a flexible molecular loop includes the set of conformations fulfilling the geometric loop-closure constraints, and its energy landscape can be seen as a scalar field defined on this implicit set. The paper by J. M. Porta and L. Jaillet on page 234 introduces the use of ...
Spulber G G Institute of Clinical Medicine, Unit of Neurology, University of Eastern Finland, University Hospital of Kuopio, Kuopio, Finland. - - 2013
Structural magnetic resonance imaging (MRI) is sensitive to neurodegeneration and can be used to estimate the risk of converting to Alzheimer's disease (AD) in individuals with mild cognitive impairment (MCI). Brain changes in AD and prodromal AD involve a pattern of widespread atrophy. The use of multivariate analysis algorithms could ...
Muthukrishnan Nandhini N Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, - - 2013
Cell-penetrating peptides such as TAT or R9 labeled with small organic fluorophores can lyse endosomes upon light irradiation. The photoendosomolytic activity of these compounds can in turn be used to deliver proteins and nucleic acids to the cytosol of live cells with spatial and temporal control. In this report, we ...
Li Xiang X Laboratory of Chemistry and Cell Biology, New York, New York 10065, - - 2013
Post-translational modifications (PTM) of proteins can control complex and dynamic cellular processes via regulating interactions between key proteins. To understand these regulatory mechanisms, it is critical that we can profile the PTM-dependent protein-protein interactions. However, identifying these interactions can be very difficult using available approaches, as PTMs can be dynamic ...
Griffin H J HJ Discipline of Exercise and Sport Science, Faculty of Health Sciences, The University of Sydney, Sydney, - - 2013
Clinical research on weight management in young women is limited. This randomized controlled trial compared the efficacy of two iso-energetically restricted (5600 kJ) diets [higher protein (HP): 32% protein, 41% carbohydrate, 25% fat or higher carbohydrate (HC): 20, 58, 21%, respectively] in 71 (HP: n = 36; HC: n = 35) young healthy women ...
Bernhards Robert C RC Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0910, - - 2013
The opportunistic pathogen Pseudomonas aeruginosa ranks among the leading causes of nosocomial infection. The type III secretion system (T3SS) aids acute Pseudomonas aeruginosa infection by injecting potent cytotoxins into host cells to suppress the host's innate immune response. Expression of all T3SS-related genes is strictly dependent on the transcription factor ...
Zhang Wei W Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL, - - 2013
Most microorganisms live in complex communities, where they interact both synergistically and competitively. To explore the relationship between environmental heterogeneity and the spatial structure of well-defined biofilms, single- and mixed-species biofilms of Pseudomonas aeruginosa PAO1 and Flavobacterium sp. CDC-65 was grown in a planar flow cell under highly controlled flow ...
Ram Ron R Bone Marrow Transplantation Unit, Rabin Medical Center, Beilinson Hospital and the Sackler School of Medicine, Tel Aviv University, Israel. - - 2013
Abstract Acute graft-versus-host disease (GVHD) has compromised and continues to compromise the benefits associated with allogeneic hematopoietic cell transplant to cure malignant and non-malignant diseases. Pharmacologic interventions to prevent GVHD have emerged as a major objective of research in the immunology and transplant fields. A better understanding of the pathobiology ...
Barbosa Sónia S Department of Medicine, Imperial College, London, W2 1PG, - - 2013
CREB3 proteins comprise a set of ER-localized bZip transcription factors defined by the presence of a transmembrane domain. They are regulated by inter-compartmental transport, Golgi cleavage and nuclear transport where they promote appropriate transcriptional responses. Although CREB3 proteins play key roles in differentiation, inflammation and metabolism, a general framework relating ...
Hyter Stephen S Department of Pharmaceutical Sciences, Oregon State University, Corvallis, OR, - - 2013
Keratinocytes contribute to melanocyte activity by influencing their microenvironment, in part, through secretion of paracrine factors. Here, we discovered that p53 directly regulates Edn1 expression in epidermal keratinocytes and controls UV-induced melanocyte homeostasis. Selective ablation of endothelin-1 (EDN1) in murine epidermis (EDN1(ep-/-) ) does not alter melanocyte homeostasis in newborn ...
Linden Jennifer R JR Graduate Program in Pathobiology, Brown University, Providence, RI, - - 2013
Candida albicans causes the majority of invasive candidiasis in immunocompromised adults while Candida parapsilosis is a leading cause of neonatal candidiasis. While much work has focused on how the immune system recognizes and responds to C. albicans, less is known about host interaction with C. parapsilosis. This study investigates the human neutrophil ...
Vinther Tine N TN Diabetes Research Unit, Novo Nordisk A/S, Novo Nordisk Park, Måløv DK-2760, - - 2013
Insulin is a key hormone controlling glucose homeostasis. All known vertebrate insulin analogs have a classical structure with three 100% conserved disulfide bonds that are essential for structural stability and thus the function of insulin. It might be hypothesized that an additional disulfide bond may enhance insulin structural stability which ...
Kirk Timothy V - - 2013
Since their introduction in 2001 miniaturized bioreactor systems have made great advances in function and performance. In this article the dissolved oxygen (DO) transfer performance of submilliliter microbioreactors, and 1-10 mL minibioreactors was examined. Microbioreactors have reached k(L) a values of 460 h(-1) , and are offering instrumentation and some ...
Callahan Brian P BP Department of Biological Sciences, University at Albany, Life Sciences Building 2061, 1400 Washington Avenue, Albany, New York 12222, USA. - - 2013
The unregulated activity of inteins during expression and consequent side reactions during work-up limits their widespread use in biotechnology and chemical biology. Therefore, we exploited a mechanism-based approach to regulate intein autocatalysis for biotechnological application. The system, inspired by our previous structural studies, is based on reversible trapping of the ...
Yang Chunyan C National Institute of Diagnostics and Vaccine Development in Infectious Disease, School of Life Sciences, Xiamen University, Xiamen 361005, People's Republic of - - 2013
The hepatitis E virus (HEV) capsid protein has been demonstrated to be able to assemble into particles in vitro. However, this process and the mechanism of protein-protein interactions during particle assembly remain unclear. In this study, we investigated the assembly mechanism of HEV structural protein subunits, the capsid protein p239 ...
Paillusson Sébastien - - 2013
There is growing evidence supporting a role of extracellular alpha-synuclein in the spreading of Parkinson's disease (PD) pathology. Recent pathological studies have raised the possibility that the enteric nervous system (ENS) is one of the initial sites of alpha-synuclein pathology in PD. We therefore undertook this survey to determine whether ...
Ma Chao C Department of Pharmaceutical Sciences, School of Pharmacy, Computational Chemical Genomics Screening Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, - - 2013
The cannabinoid receptor subtype 2 (CB2) is a promising therapeutic target for blood cancer, pain relief, osteoporosis, and immune system disease. The recent withdrawal of Rimonabant, which targets another closely related cannabinoid receptor (CB1), accentuates the importance of selectivity for the development of CB2 ligands in order to minimize their ...
Graham Joseph G JG Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, - - 2013
The intracellular bacterial pathogen Coxiella burnetii is a category B select agent that causes human Q fever. In vivo, C. burnetii targets alveolar macrophages wherein the pathogen replicates in a lysosome-like parasitophorous vacuole (PV). In vitro, C. burnetii infects a variety of cultured cell lines that have collectively been used to model ...
Zhang Chuanbo C Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, - - 2013
TNFAIP8 is a NF-κB-inducible, oncogenic molecule. Previous "promoter array" studies have identified differential methylation and regulation of TNFAIP8 in prostate epithelial and cancer cell lines. Here we demonstrate that TNFAIP8 expression is induced by androgen in hormone-responsive LNCaP prostate cancer cells. In athymic mice bearing hormone-refractory PC-3 prostate tumor xenografts, ...
Jonassaint Naudia L NL Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, - - 2013
Defects in telomere maintenance genes cause pathological telomere shortening, and manifest in syndromes which have prominent phenotypes in tissues of high turnover: the skin and bone marrow. Because the gastrointestinal (GI) epithelium is highly proliferative, we sought to determine whether telomere syndromes cause GI disease, and to define its prevalence, ...
Balendhran Sivacarendran - - 2013
Extremely high carrier mobilities are achieved in layered molybdenum oxide by Sivacarendran Balendhran, Kourosh Kalantar-zadeh, and co-workers on page 109. This is achieved by intercalation of the octahedral molybdenum oxide lattice with hydrogen, which tunes the bandgap of the material. Carrier mobilities of 1100 cm(2) V(-1) s(-1) and greater are ...
Kumar Shailesh - - 2013
Linear arrays of vertically aligned carbon nanotubes (VACNTs) can be produced by directly exposing thin linear features written on a Si wafer to non-uniform plasmas, as reported by Kostya (Ken) Ostrikov and co-workers on page 69. This approach can be used to produce virtually any pattern of linear arrays of ...
Jiang Ling-Feng - - 2013
This study aimed to assess whether maifanite can improve the learning and memory, and antioxidant abilities of Alzheimer's disease (AD) rats. The 70 rats were divided into seven groups: [A] normal control group, [B] AD model group, [C] sham group, [D] positive control group (donepezil), [E] low-dose maifanite group, [F] ...
Kim Jae-Hyung - - 2013
BACKGROUND: To measure the efficiency of phacoemulsification, we have developed a new experimental model for testing phaco-efficiency and analyzed re-aspiration of repulsed particles. METHODS: Using a Kitaro wetlab system, a piece of blood agar (BA) was placed in an artificial chamber and the phacoemulsifier was placed horizontally. The settings of ...
Sachdev Dhara P - - 2013
Agricultural productivity to meet growing demands of human population is a matter of great concern for all countries. Use of green compounds to achieve the sustainable agriculture is the present necessity. This review highlights the enormous use of harsh surfactants in agricultural soil and agrochemical industries. Biosurfactants which are reported ...
Basu Subhajit - - 2013
A massive algal bloom of the dinoflagellate Noctiluca miliaris (green) was located in the Northern Arabian Sea by IRS-P4-2 (OCM-II) for microbiological studies, during two consecutive cruises of February-March 2009. Culturable bacterial load during bloom were ∼2-3-fold higher in comparison to non-bloom waters and ranged from 3.20 × 10(5) to 6.84 × 10(5) cfu ml(-1). An ...
Wang Run L - - 2013
Two experiments were conducted to examine the effect of zinc (Zn) source on the performance, Zn status, immune response, and rumen fermentation of lactating cows to find the most available Zn source for dairy production. In Experiment 1, a total of 30 multiparous Holstein cows were randomly allocated by body ...
Froelich Brett - - 2013
The human bacterial pathogen, Vibrio vulnificus, is found in brackish waters and is concentrated by filter-feeding molluscan shellfish, especially oysters, which inhabit those waters. Ingestion of raw or undercooked oysters containing virulent strains of V. vulnificus can result in rapid septicemia and death in 50 % of victims. This review summarizes ...
Chaudhary M Z - - 2013
Sediment core from Korangi Creek, one of the polluted coastal locations along the Karachi Coast Pakistan, was collected to trace the history of marine pollution and to determine the impact of industrial activity in the area. Down core variation of metals such as Ca, K, Mg, Al, S, Ti, V, ...
Vezzulli Luigi - - 2013
Vibrios are among the most common bacteria that inhabit surface waters throughout the world and are responsible for a number of severe infections both in humans and animals. Several reports recently showed that human Vibrio illnesses are increasing worldwide including fatal acute diarrheal diseases, such as cholera, gastroenteritis, wound infections, ...
Rębacz-Maron Ewa - - 2013
Mineral imbalance in the body may significantly contribute to the development and course of hypertension. In this paper, blood pressure figures have been linked to the levels of Fe, Ca, Mg, Zn, Cu, Na and K in hair. The research sample was composed of young men (n = 91) aged 13-21, from ...
Gil-Ibáñez Blanca - - 2013
BACKGROUND: This work assessed the role of robotic-assisted lapararoscopic radical hysterectomy in the treatment of early invasive cervical cancer with special regard to nerve sparing technique. METHODS: Between October 2009 and June 2011, a total of 14 non-consecutive patients underwent early cervical cancer surgery at the authors' institution. Patients with ...
Malkowska Maja - - 2013
ABSTRACT: Herpesviridae is a large family of DNA viruses divided into three subfamilies: Alpha-, Beta- and Gammaherpesvirinae. The process of herpesvirus transmission is mediated by a range of proteins, one of which is glycoprotein L (gL). Based on our analysis of the solved structures of HSV2 and EBV gH/gL complexes, ...
Lee Chang Hoon - - 2013
Photolysis of [Ni(II)(μ-Cl)Cl(IPr)](2) (IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene) activates the Ni-Cl bonds to furnish [Ni(I)(μ-Cl)(IPr)](2). Consistent with this photochemistry, a TD-DFT calculation for square planar Ni(ii) centre reveals that light excitation leads to the population of orbitals with σ*(Ni-Cl) character.
Grant Murray R MR College of Life and Environmental Sciences, University of Exeter, Exeter, Stocker Road, Exeter, EX4 4QD, UK. - - 2013
With expansion of our understanding of pathogen effector strategies and the multiplicity of their host targets, it is becoming evident that novel approaches to engineering broad-spectrum resistance need to be deployed. The increasing availability of high temporal gene expression data of a range of plant-microbe interactions enables the judicious choices ...
Enriquez-Algeciras Mabel M Bascom Palmer Eye Institute, University of Miami, Miami, Florida, - - 2013
Progressive loss of visual function frequently accompanies demyelinating diseases such as multiple sclerosis (MS) and is hypothesized to be the result of damage to the axons and soma of neurons. Here, we show that dendritic impairment is also involved in these diseases. Deimination, a posttranslational modification, was reduced in the ...
Danielsen Anne K - - 2013
AIMS AND OBJECTIVES: To examine patients' experiences of impact of a temporary stoma on their everyday life. Furthermore, we wanted to generate new knowledge and comprehension of learning how to live with a temporary stoma. BACKGROUND: There are many aspects, largely unexplored, that may influence patients' adaptation to life with ...
Lewis Fiona M - - 2013
Background: Neonatal screening for galactosaemia (GAL) identifies the condition early, but subsequent biomedical and genetic testing fails to identify which subgroup of infants with GAL are at most risk of the language disorders associated with the condition. This study aims to present preliminary data on an infant with GAL based ...
Gölitz Peter - - 2013
A rousing force emanates from the important findings, which, in turn, inspires receptive natures to strive for achievements of their own. We produce our journal for such people. And we seek out these avant-garde. This constitutes our entire program. This program for Angewandte Chemie was formulated by Wilhelm Foerst 50 ...
Ko Ji Hyun JH Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, - - 2013
In vivo imaging of translocator protein 18 kDa (TSPO) has received significant attention as potential biomarker of microglia activation. Several radioligands have been designed with improved properties. Our group recently developed an (18)F-labeled TSPO ligand, [(18)F]-FEPPA, and confirmed its reliability with a 2-tissue compartment model. Here, we extended, in a group ...
Tse Mimi My - - 2013
AIMS AND OBJECTIVES: To examine the effectiveness of an integrated motivational interviewing and physical exercise programme on pain, physical and psychological function, quality of life, self-efficacy, and compliance with exercise for community-dwelling older persons with chronic pain. BACKGROUND: Chronic pain is common among older persons. Indeed, motivation for managing pain ...
Schaier Matthias - - 2013
Regulatory T cells (Tregs) were shown to be involved into the pathogenesis of acute rejection after transplantation. The suppressive activity of the total regulatory T cell pool depends on its percentage of highly suppressive HLA-DR(+) -Treg cells. Therefore, both the suppressive activity of the total Treg pool and the extent ...
Fakhratova Malika - - 2013
ABSTRACT Purpose: To determine the cause of Leber congenital amaurosis (LCA) in a consanguineous Emirati family. Methods: The clinical diagnosis was made on the basis of medical history, ophthalmoscopy and standard ERG. The diagnosis was confirmed by molecular genetic analysis of known LCA genes by Next-Generation Sequencing (NGS). The latter ...
Abu-Kishk Ibrahim - - 2013
BACKGROUND: It is common practice for patients to be admitted to the intensive care unit following scoliosis surgery, because of the prolonged anesthesia, the need for efficient pain control and the known immediate postoperative complications. However, this may be unnecessary in many patients. PURPOSE: We aimed to establish possible associations ...
Won K-J KJ Department of Physiology & Cell Biology, University of Nevada School of Medicine, Reno, NV, - - 2013
The colon undergoes distension-induced changes in motor activity as luminal contents or feces increase wall pressure. Input from enteric motor neurons regulates this motility. Here we examined stretch-dependent responses in circular muscle strips of murine colon. Length ramps (6-31μm s(-1) ) were applied in the axis of the circular muscle ...
Roos Carolien C Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Centre, Local Postal Code 791, PO Box 9101, 6500 HB, Nijmegen, The Netherlands. - - 2013
In threatened preterm labor, maintenance tocolysis with nifedipine, after an initial course of tocolysis and corticosteroids for 48 hours, may improve perinatal outcome. To determine whether maintenance tocolysis with nifedipine will reduce adverse perinatal outcomes due to premature birth. APOSTEL-II (Assessment of Perinatal Outcome with Sustained Tocolysis in Early Labor) ...
Porporato Paolo E PE Department of Translational Medicine, Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), and Biotechnology Center for Applied Medical Research (BRMA), Università del Piemonte Orientale "Amedeo Avogadro" — Alessandria, Novara, Vercelli, - - 2013
Cachexia is a wasting syndrome associated with cancer, AIDS, multiple sclerosis, and several other disease states. It is characterized by weight loss, fatigue, loss of appetite, and skeletal muscle atrophy and is associated with poor patient prognosis, making it an important treatment target. Ghrelin is a peptide hormone that stimulates ...
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